knockouts
because all of us at evolve daily are very impressed by these swift knockouts, we’ve compiled several of the fastest boxing knockouts of all time. are you ready to get blown away? today, evolve daily shares 5 fastest knockouts in boxing history. psst! if you blink, you might miss the kos !
one of the most shocking knockouts happened in a knockdown - dragout affair between scott smith and pete sell .
the octagon has played host to a number of jaw - dropping moments—knockouts in particular. with that in mind, bleacher report' s steven rondina and nathan mccarter are here to sift through recent ufc history and pick out some of the most shocking ufc knockouts .
here are the 15 most brutal knockouts in boxing' s rich history. if you have a weak stomach please don' t watch .
just saw the hollywood knockouts at the silver spur saloon. it was such a fun night thank you ladies for being amazing! ! !
while it never quite panned out that way, peter was known for some of the spectacular knockouts he was able to lay on his opponents .
quite simply the 20 most terrifying knockouts in boxing history. featuring look - away - now knockouts from tyson, foreman, mercer, tua, jackson and many many more! !! subscribe for the latest top 10’s, promo' s, series & tributes. youtube: urltoken facebook: urltoken twitter: urltoken
but that isn' t what this is about. we' re talking knockouts here. they are what makes the sport of boxing so dramatic, so unique .
always a blast mama knockout and her girls. seen them numerous times and even booked them for daytona bike week. the hollywood knockouts know how to put in a show .
we here at lowkickmma have combed through the archives to find the best one - punch shots. take a look at five of the most brutal one - punch knockouts in ufc history !
undoubtedly, when you think about boxing, you think about punching power and knockouts — slick combinations that capture the imagination, and displays of heart and will. but beneath the surface lies a wealth of technique…
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if you win the tournament outright, you’ll not only win your opponent’s bounty but your own as well, plus regular prize money and all the collective bounties you’ve accrued from knockouts so there’s a huge payday for the winner of any progressive ko tourney .
quite simply, the top 20 most brutal knockouts in the history of the sweet science. a must watch for all boxing fans! subscribe for the latest boxing promo' s, series and tributes. youtube channel: urltoken facebook page: urltoken twitter page: urltoken
there have been literally thousands of incredible knockouts in boxing history and this list doesn' t seek to cover all of them. it' s a springboard for discussion, debate and argument. feel free to add your own favorites from the spectacular to the improbable .
evans punch got there first, and the rest is history. liddell was knocked out cold in the second round, and continued “the iceman’s” downfall. liddell would retire two years later after suffering two more vicious knockouts at the hands of mauricio “shogun” rua and rich franklin .
the photo of the kick landing is now iconic in the sport. and the tale of seagal' s teaching silva the kick is an additional story that captivated the minds of the mma community. all of it circles the front kick making it one of the most special, and electrifying, knockouts in history .
the pakistani study is the first in which researchers tested some of the knockouts they had found to learn more about their health, says human geneticist david van heel of queen mary university of london, who last year published a smaller knockout study of british - pakistanis. because these individuals are so rare, “we really all need to keep going to sequence more and more people, ” he says. about 200, 000 pakistanis would be enough to find knockouts of about 8700 genes, kathiresan’s team estimates. (some of these genes are essential to early development, however, so a human knockout would never be born. )
referee dan miragliotta, for reasons known only to him, let the action continue well past the point where others would end the bout. ultimately, that decision was vindicated when a wobbly kongo reared back, cracked barry with a right hook and knocked him out cold on the spot, giving the french striker one of the most shocking and memorable knockouts in ufc history .
* * no copyright infringement intended * * follow me on facebook - urltoken support me on patreon - urltoken my selection of the 10 best delayed reaction knockouts. ; 1) alexander dimitrenko ko3 luan krasniqi 2) michael perez ko1 miguel rodriguez 3) pernell whitaker ko1 juan nazario 4) ricardo lopez ko8 alla vilamor 5) marcel cerdan rtd11 tony zale 6) sechew powell tko1 cornelius bundrage 7) kostya tszyu tko2 zab judah 8) mike tyson tko2 trevor berbick 9) earnie shavers ko10 tiger williams 10) luisito espinosa ko1 khaokor galaxy the last one might be the longest delayed reaction knockout in history! do you know of a longer one? what are some of the best delayed reaction knockouts that you have seen? let me know in the comments! remember to subscribe! keep punching boxing heads !
epic countdown of the 20 greatest middleweight knockouts of all time. featuring marvin hagler, sergio martinez, ray robinson, felix trinidad, bernard hopkins, gennady golovkin, saul alvarez, dmitry pirog, gene fullmer & many more! subscribe for the latest boxing top 10’s, promo' s, series & tributes. youtube: urltoken facebook: urltoken twitter: urltoken instagram urltoken patreon: urltoken audio credits: urltoken
the study is the latest of several hunts for apparently healthy human knockouts that have included iceland and the united kingdom. “the human genome project gave us a parts list of 18, 000 genes, and this project is trying to understand what missing a part means in terms of biological consequences, ” says heart disease geneticist sekar kathiresan of the broad institute in cambridge, massachusetts, who co - led the study .
when scientists want to figure out what a specific gene does in mice, they knock it out. that can’t be done with humans, but some people are natural knockouts—born missing one or more genes. now, a look at the dna of 10, 500 pakistanis has found more than 1300 genes that are knocked out without causing obvious medical issues. the results may help confirm why a new heart disease drug flopped in clinical trials, and why another new drug should work just fine .
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forgotten american heavyweights of the nineties, derrick jefferson and maurice harris weren' t exactly world championship material, but they were, on a november night in 1999, involved in one of the craziest one - punch knockouts in the division' s history. a heavyweight knockout in every sense of the word, both men loaded their left hands and let them go at roughly the same time, only for jefferson to get there first – and harder. the shot' s devastating impact saw harris' gum shield exit his mouth and the ring, and his entire body give out like a tree felled in the middle of a forest. unconscious with his eyes wide open, the image of harris horizontal provided a reminder of just how much damage a heavyweight, irrespective of ability or calibre, can do with a single shot .
you could draw up a list of julian jackson' s five greatest knockouts and the choices and order would cause debate. you' d need more spaces. certainly, though, if pushed to narrow down a life' s handiwork to just one, most would point to the hawk' s knockout of poor herol
bomber
graham, as being the moment that best epitomises the virgin islander' s ability to turn things around with one brutal swing of his fist. that night in spain, jackson, behind on points, was frustrated by graham' s slick sheffield style and sleepwalked through three - and - a - half rounds of a world title fight. but then, halfway through the fourth, as graham began to get comfortable and confident, the greatest knockout artist of all - time launched the mother of all right hooks to deck his opponent and produce a scene straight from a video game .
a major goal of biomedicine is to understand the function of every gene in the human genome 1. loss - of - function mutations can disrupt both copies of a given gene in humans and phenotypic analysis of such ‘human knockouts’ can provide insight into gene function. consanguineous unions are more likely to result in offspring carrying homozygous loss - of - function mutations. in pakistan, consanguinity rates are notably high 2. here we sequence the protein - coding regions of 10, 503 adult participants in the pakistan risk of myocardial infarction study (promis), designed to understand the determinants of cardiometabolic diseases in individuals from south asia 3. we identified individuals carrying homozygous predicted loss - of - function (plof) mutations, and performed phenotypic analysis involving more than 200 biochemical and disease traits. we enumerated 49, 138 rare (< 1% minor allele frequency) plof mutations. these plof mutations are estimated to knock out 1, 317 genes, each in at least one participant. homozygosity for plof mutations at pla2g7 was associated with absent enzymatic activity of soluble lipoprotein - associated phospholipase a2; at cyp2f1, with higher plasma interleukin - 8 concentrations; at treh, with lower concentrations of apob - containing lipoprotein subfractions; at either a3galt2 or nrg4, with markedly reduced plasma insulin c - peptide concentrations; and at slc9a3r1, with mediators of calcium and phosphate signalling. heterozygous deficiency of apoc3 has been shown to protect against coronary heart disease 4, 5; we identified apoc3 homozygous plof carriers in our cohort. we recruited these human knockouts and challenged them with an oral fat load. compared with family members lacking the mutation, individuals with apoc3 knocked out displayed marked blunting of the usual post - prandial rise in plasma triglycerides. overall, these observations provide a roadmap for a ‘human knockout project’, a systematic effort to understand the phenotypic consequences of complete disruption of genes in humans .
sample recruitment and phenotyping was performed by d. s. , p. f. , j. d. , a. r. , m. z. , m. s. , a. i. , s. a. , f. ma. , m. i. , s. a. , k. t. , n. h. m. , k. s. z. , n. q. , m. i. , s. z. r. , f. me. , k. m. , n. a. , and r. m. k. d. s. , p. f. , j. d. , and w. z. performed array - based genotyping and runs - of - homozygosity analyses. exome sequencing was coordinated by d. s. , n. g. , s. g. , e. s. l. , d. j. r. , and s. k. p. n. , w. z. , h. h. w. , and r. d. performed exome - sequencing quality control and association analyses. p. n. , i. m. a. , k. j. k. , a. h. o. , b. w. , and d. g. m. performed variant annotation. d. s. , s. k. , and d. j. r. performed confirmatory genotyping and lipoprotein biomarker assays. d. s. and a. r. conducted recall - based studies for the apoc3 knockouts. p. n. and m. j. d. performed bioinformatics simulations. p. n. and k. e. s. performed constraint score analyses. d. s. , p. n. , and s. k. designed the study and wrote the paper. all authors discussed the results and commented on the manuscript .
anything can happen in mma
is a cliche, but it wouldn' t have survived this long if it weren' t accurate. over the many years of the ufc' s existence, fans have seen things so absurd and so spectacular that they pushed the boundaries of what seemed possible in combat sports .
if michael bisping were in the wwe, he would be looked at as one of the greatest intercontinental champions of all time. that may sound like high praise, but wrestling fans know how backhanded a compliment that is .
over the last 20 years, the intercontinental championship has been a belt dedicated to keeping the second tier of superstars busy. it’s for the guys the promotion likes to have around and likes to have on cards, but not the ones that are legitimate top - guy material. it' s a belt for the good ones... but not the great ones .
that’s the niche that bisping fell into. top billing on a cable tv fight night card? sure. pay - per - view co - main event? absolutely. actual title fight? haha... no .
the fates and injury bugs eventually conspired to get him a title shot at ufc 199 opposite luke rockhold. it was supposed to be a feel - good moment. not because he would win, of course. there was no way he was going to do that .
but hey, after 10 years in the ufc, he finally got a title shot. that’s something, right? wrong .
in one of the greatest swerves in ufc history, he landed the hardest punch of his career on the biggest stage he’d ever been on against an opponent who mauled him just 19 months prior. ten years and more than 20 fights into his ufc career, the brash brit became one of the ufc’s most unlikely champions in one of the most absurd upsets in the promotion’s history .
it was difficult to come to terms with what happened between chris weidman and anderson silva at ufc 162. the spider, the goat, felled in decisive fashion. out - wrestled, suckered by a backfist and then knocked out cold with a left hook by the younger american .
in a fight involving anyone else, this would have been forgotten. silva, though, set the standard for mma dominance. like a hurricane hitting an island, it wasn' t a question of what would happen; it was a discussion of how much damage would be done by the time it was over .
but weidman beat him. knocked him out cold and left the rest of the mma world to figure out what just happened .
it' s somewhat odd, in retrospect. silva wasn' t all that far removed from nearly losing to chael sonnen. on the flip side, weidman was already pegged as the rolled - up newspaper that would one day squash the spider. when they finally stepped into the cage, the betting lines reflected this .
but even for the biggest weidman believers, the sight of silva' s losing was far more difficult to grasp than the simple thought of it. silva was unbeatable... until he wasn' t .
there was little doubt that this ko would make the list. ufc’s biggest event to date was ufc 100. two magnificent title fights and an undercard to satisfy even the most picky fan. on the main card, right before gsp took on thiago alves, the ultimate fighter coaches dan henderson and michael bisping were set to meet to settle their beef .
everyone knows the story now. bisping circled right into henderson’s power and took the h - bomb clean. bisping went stiff, and henderson leaped into the air with one of the most astonishing, egregious yet memorable flying forearms in mma history. it was the exclamation point of a man who had heard enough of bisping’s trash talk .
the crowd was stunned. not because henderson hadn' t knocked anyone out before, because he certainly had, but at the stiffened body of bisping and the audaciousness of the follow - up shot. no matter how many times you witness it in a replay, it' s still a gasp - inducing ko .
not many would expect that eight years later bisping would stand atop the division after having defended his title against henderson in a rematch where henderson almost stopped him again. all of that was set off from this moment .
a knockout can be scary, a knockout can be beautiful and, every once in a while, a knockout can be both. edson barboza’s wheel - kick victory over terry etim is one of the few that makes that cut .
there’s a distinct smoothness to the brazilian’s kicking game. he moves around the cage in a slick manner, snapping his leg at opponents with a confidence that few others have while giving ringside photographers the easiest night of their careers as he hammers opponents in the most picturesque ways possible .
and when an opponent gives him as much room as etim did back in 2012, the octagon is his canvas .
the reality of the situation comes back when he lands, though. no matter how pretty those strikes look, they’re thrown with hurtful intent. his beautiful spinning kick was no exception. the shot landed clean to etim’s face, leaving him so stiff that his arms didn’t even touch the mat when he fell .
it’s easy to look back on this knockout and marvel at barboza’s pure technical prowess. but it’s even easier to recoil a bit at how devastating the finishing blow was .
being there live from press row was surreal. the hype and anticipation of the week for conor mcgregor to finally meet jose aldo, who would surely be his biggest test, was off the charts. the fight began, and just a few ticks into it, shielded from the punch itself, i saw aldo fall to the canvas in what seemed like slow motion. the hammerfists were the cherry on mcgregor’s sundae .
the highlight showed what most missed in real time: a perfect left turning off aldo’s lights. mcgregor’s post - fight quote brilliantly summed up the fight :
he’s powerful and he’s fast. but precision beats power and timing beats speed, and that’s what you saw there .
the long - awaited title tilt between anderson silva and vitor belfort was set. for all the different matchups that silva had faced in his run as middleweight champion, he had yet to take on a fierce striker with such quick, powerful hands. how would he handle the challenge ?
silva' s respect was evident by his cautious approach in the opening moments of the fight. belfort came forward and silva dodged the initial approach. belfort took silva down off a right high kick for just a moment before the spider popped back to his feet. it was belfort' s doom shortly after .
“he front - kicked him in the face, ” joe rogan shouted in a now - famous call. a couple of follow - up punches on the ground, and silva had defended his throne once again. silva' s aura only grew because of the knockout, especially after telling media during the ufc 126 post - fight that steven seagal had taught him the technique .
georges st - pierre is one of the single greatest fighters of all time. his boxing? crisp, clean and difficult to advance on. his wrestling? immaculate, both offensively and defensively .
he’s impossible to beat, right? well, matt serra managed to pull off the greatest upset in ufc history at ufc 69 when he somehow, some way, beat the welterweight champion .
after a slow courting period, serra caught gsp with a haymaker square behind the ear. the canadian, for a couple of seconds, seemed to shrug it off, but a stumble as he backed away was all serra needed to hit the gas. a ferocious flurry ensued, and the champ never had the opportunity to recover. he ate massive right hand after massive right hand before he finally tapped to strikes .
this fight has slipped into the annals of history. serra went 1 - 3 afterward and quietly retired in 2013 while st - pierre reclaimed the title a year later to begin one of the most dominant reigns in ufc history. those who witnessed the plucky lightweight work his way through the ultimate fighter and pull off one of mma’s greatest heists, though, won’t ever forget this one .
the fourth title defense for ronda rousey was something special in an already - spectacular career. rousey was coming off a tko over sara mcmann—her first non - armbar victory .
the storyline going in was how alexis davis’ jiu - jitsu would help her stop rousey’s grappling attack. but we never got the chance to find out .
rousey knocked davis out on the feet, but almost nobody knew because davis slumped over and rousey tossed her like a bag of laundry. davis hit with a thud and rousey nailed her with punch after punch on the canvas, where it quickly became evident davis had gone into her rem cycle. the referee stopped the fight, and davis tried hitting a single on him thinking he was rousey .
no one expected the result. until this moment, the anticipation of a rousey fight was all about how long it would take her to get an armbar. the mcmann fight was an aberration. the former olympian now had ko power to stop a fight in under 30 seconds? no one could have called that .
sixteen seconds was the official time, and the fight went viral on instagram. during the height of her run, rousey could do no wrong, and this was another example of that .
ufc 189 will likely go down as the night conor mcgregor won his first ufc championship. but for hardcore fans of the sport, it will always be the night robbie lawler and rory macdonald put on one of the best welterweight title fights .
it was the unanimous pick for 2015 fight of the year, and it makes this list for the gnarly and gruesome finish .
after the war had been waged for 20 minutes, the horn sounded to end the fourth. lawler and macdonald, battered and bloodied, stood in the center of the octagon staring each other down in a special moment that only heightened the stakes .
the fifth lasted 60 seconds. lawler, having already damaged macdonald’s nose, crushed it one last time. macdonald fell to the canvas. every man has his limit. the pain was too much to bare. a broken nose eating one more power punch... shattered .
the two combatants met at the local hospital for a post - fight picture together. the war they shared created a special bond that few will understand. lawler retained his championship by pushing macdonald to the limit and finally pushing him over .
if you watched the sport of mma in 2001, there was almost nothing more shocking than the first spinning backfist ko in ufc history .
matt serra made his ufc debut as an undefeated 4 - 0 fighter. his grappling background made him an interesting prospect with a high ceiling. he was well on his way to winning his debut over shonie carter at ufc 31. carter would not have won if the fight went to the scorecards .
as the final horn neared, carter unleashed a spinning backfist that connected cleanly. serra fell and the fight was stopped. nine seconds before certain defeat, mr. international stunned serra and the audience with a knockout from nowhere .
serra got his payback during the ultimate fighter: the comebacks in 2006. he got the decision nod in the semifinals over carter, but once again, serra got nailed with the spinning backfist. serra went on to win the season before capturing the welterweight championship with his own shocking upset ko over gsp .
many spinning techniques have since thrived in the ufc, but few stunned the sport like carter’s backfist .
the tale of arrhichion of phigalia is one of the oldest legends of combat sports. in the final round of the 564 bc olympic pankration games, arrhichion was choked unconscious by an opponent... then choked dead not long after. as the life left his body, though, his corpse flopped down on his opponent' s leg, injuring the other man' s ankle and forcing a concession. that resulted in a posthumous win for arrhichion and allowed him to ultimately be laid to rest as an undefeated, three - time olympic champion .
of course, it' s easy to wonder whether this is true or just a tall tale that happened to withstand two - and - a - half millennia. matt hughes' improbable title victory over carlos newton, however, suggests there' s at least a possibility .
at ufc 34 in 2001, newton locked up a tight triangle choke on hughes. while there are a number of different ways to defend this, hughes dead - lifted the champion and worked himself back into a standing position with newton against the cage .
it was an impressive display of strength, but the choke was still sunk in deep and, ultimately, was in tight enough that hughes passed out. the challenger fell, but in a strange twist, newton fell further and was left unconscious on impact. the referee declared the contest over, with hughes being the victor via knockout .
dubious outcome? maybe. still, it was one of the most iconic moments of the era and was the beginning of hughes' lengthy reign as ufc welterweight champion .
the first happened in las vegas. after making his untouched debut against chris leben, silva would get a crack at the ufc champion in one of the first true top contender matches in ufc history .
silva got the thai clinch and brutalized franklin. absolutely brutalized the man. a knee up main street broke franklin’s nose and sent silva, and the ufc, into a new era. the anticipation behind the fight was going to be a battle of wills, but it was barely even a contest .
just over a year later, franklin earned his rematch, this time in his hometown of cincinnati, ohio. it only went marginally better for the former champion. silva dodged his strikes as if in an instructional video and then nearly finished with a late first - round ko. the horn saved franklin, but he was out of it between rounds .
silva finished off ace in the second without much issue, which put an end to franklin as a title contender. silva showed the wide gap between the two, and no one ever wanted to see a third fight. these two fights show why the ballet of violence tag fits so well with one of the sport' s most fascinating and enduring champions .
the first result was startling because of the discrepancy in talent and an unexpected quick finish due to it. the second result wasn' t as shocking but began silva' s allure in the ufc as a flamboyant personality inside the cage .
there is no denying how dominant ronda rousey was as ufc bantamweight champion. she beat sara mcmann in 66 seconds. then alexis davis in 16 seconds. then cat zingano in 14 seconds. then bethe correia in 34 seconds. no matter the skeptics, it was right to expect her to maul anyone who went toe - to - toe with her .
rousey had always been a hittable fighter. even in her most impressive victories, she was always willing to absorb punches in order to get an opponent in the clinch. none of rousey’s foes had the tools to avoid that, and few had the athleticism to escape her black hole of offensive weapons for long. holm did, though, and as rousey waded forward, she never got a return on her investment .
after being repeatedly wounded, rousey slipped during an exchange, turned her back in an attempt to disengage but rotated around right in time to meet holm’s foot. she collapsed on the spot and, in that instant, the mma scene changed .
granted, holm had the perfect skill set and coaches to dissect rousey, who was walking a tightrope as she balanced careers in both hollywood and the octagon .
neither man would fool you with quick footwork and deceptive head movement. no, they would just stand and trade. which is what they did on the undercard of the ultimate fighter 4 finale, in which both men had been participants .
in the second round, sell hit smith with a beautiful left hook to the liver. smith grabbed his side in agony. seeing that, sell went in for the finish and made a critical error: he dropped his hands and darted over to smith without protecting himself. smith uncorked one vicious right hand that landed on the button and put sell out .
smith was in so much pain from the shot he couldn’t celebrate. he lay on the canvas writhing. sell had the victory had he just protected himself as he entered. the excitement got the better of him, and smith took full advantage with the one shot he had left in the tank .
a competitor being knocked out multiple times within one bout is unfortunately normal in mma. referees are slow to stop fights. cornermen refuse to do so under any circumstances. fighters have far too much fight in them .
fighters and coaches are willing to hold onto any sliver of hope for victory. no matter how many strikes they’ve absorbed, how hyperextended their joints are or how unsteady they are on their feet, they close their eyes and tell themselves ,
maybe, just maybe, something like cheick kongo vs. pat barry will happen .
indeed, kongo vs. barry stands tall as the most ridiculous comeback in the history of the sport .
at 2: 47 of round 1, kongo was dropped hard by an overhand right that landed behind his ear. barry stayed on him and landed a dozen punches while kongo tried to scramble back to his feet. he made it upright once more but was sent crashing to the canvas by another huge punch .
this wasn' t a high - stakes fight or an especially technical affair, but it sticks out in a way few others do. it is the greatest example of the phrase
anything can happen in mma .
anderson silva' s
ballet of violence
also applies to what rashad evans did to chuck liddell .
liddell was still in the title picture in 2008, and evans was seeking his breakthrough moment. liddell was coming off his spectacular war with wanderlei silva, which rejuvenated his career following back - to - back losses to quinton
rampage
jackson and keith jardine .
evans was the underdog, per urltoken, and if he were to win it would be another classic, boring rashad evans wrestling performance. there' s no way he could out - strike the legendary
iceman
. evans simply wasn' t championship material. few picked him to win as this was stylistically favorable to what liddell did best throughout his career .
evans ended liddell' s redemption run with one right hand, proving he was, in fact, one of the elite. evans silenced the crowd and his doubters with one punch .
a picture - perfect overhand obliterated liddell. perhaps thankfully, liddell dropped quickly as a left hook was coming behind it. liddell was shown on the mat completely out of it while evans did his best fred sanford around the octagon. replays showed the impact the right had on liddell’s neck as he shut off the lights .
the sound alone was sickening. pound - for - pound, it may still be the most violent and brutal knockout in ufc history .
it' s hard to overstate how much of a shock mirko filopovic vs. gabriel gonzaga was .
cro cop was one of the most vicious men in japan’s pride fc. he was a kickboxer - turned - fighter who routinely left the most terrifying competitors in all of combat sports in twisted heaps. he was the single best striker in the sport at the time and probably ever. he was the deadliest finisher on earth, with an almost - too - accurate catchphrase for his kicking game: right leg hospital, left leg cemetery .
when he made the long - awaited jump from the japanese circuit to the ufc, american fans were eager to see him roar his way to a shot at heavyweight champion randy couture. gonzaga was a layover on that trip... or he was supposed to be .
after scoring an early takedown and working cro cop over on the canvas, it was obvious that gonzaga wasn’t the tomato can many were expecting .
just one kick ,
said every cro cop fan on earth .
just one kick, and the fight’s over .
and they were right, only it was cro cop on the receiving end of a big boot .
seeing one of the best, most popular heavyweights of the era crumble after being hit with his own technique probably would have been enough to get this fight on the list. but the memory of cro cop’s leg being coiled underneath him as he fell seals up its place as the most shocking knockout in ufc history .
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a genetics study in pakistan has turned up 1300 genes that humans can live without .
in pakistan, people often marry their first cousins. that raises the odds that a mother and father will both pass identical copies of a mutation in a specific gene to their children. (unless the mutated gene is on a sex chromosome, both parental copies of a gene have to be disabled for a full knockout .) kathiresan’s group sequenced the dna of 10, 503 pakistanis who are participating in a long - term heart disease and diabetes study and found 1317 fully knocked - out genes. the team then looked for abnormalities in about 200 clinical blood biomarkers such as cholesterol .
seven genes were disabled in at least two people and clearly matched up with some biomarker change, such as unusually low insulin levels, the team reports today in nature. one codes for an enzyme called lp - pla2 that has been linked to arterial plaque. because higher blood levels of lp - pla2 correlate with more heart attacks, drug companies have already spent billions of dollars on lp - pla2–blocking drugs. but pakistanis who lacked one or both copies of the gene didn’t have a lower risk of heart disease, which adds to other genetics studies that may explain why these drugs failed in the clinic .
on the other hand, the study found strong support for another heart disease drug target, a protein called apoc - iii that limits the body’s ability to metabolize fats called triglycerides. although kathiresan’s team has studied people missing one copy of the apco3 gene, “we' ve been looking for the past 4 years for humans who completely lack it. ” they had found none in the united states and europe, he says, but in pakistan, his group identified a whole family where both parents and all nine of their children lack the apco3 gene .
when the family members drank a fat - laden milkshake, their blood fat levels barely rose, suggesting they have little artery - clogging fat in their bodies and should be protected against heart attacks. the family also seemed perfectly healthy, so apoc - iii–blocking drugs now in clinical testing should be safe, kathiresan predicts. the drugs could eventually join another heart disease–preventing drug that came out of the discovery of a healthy woman missing a gene called pcsk9 .
kathiresan and others is now calling for a human knockout project that would pool all the data coming out of these projects and other large population genetics studies in a single database. co - author daniel macarthur of the broad institute will soon release a prototype containing knocked - out genes from a larger collection of human genomes called exac. eventually the plan is to make it possible for academic researchers—and drug companies—to reach out to the leaders of the original study so they can contact an individual knockout from the database and bring the person into a clinic for more testing .
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interleukin - 8 gene expression by a pulmonary epithelial cell line. a model for cytokine networks in the lung
exchanger regulatory factor 1 (nherf1) null mice. camp inhibition is differentially dependent on nherf1 and exchange protein directly activated by camp in ileum versus proximal tubule
d. s. is supported by grants from the national institutes of health, the fogarty international, the wellcome trust, the british heart foundation, and pfizer. p. n. is supported by the john s. ladue memorial fellowship in cardiology from harvard medical school. h. - h. w. is supported by a grant from the samsung medical center, korea (smo116163). s. k. is supported by the ofer and shelly nemirovsky mgh research scholar award and by grants from the national institutes of health (r01hl107816), the donovan family foundation, and fondation leducq. exome sequencing was supported by a grant from the nhgri (5u54hg003067 - 11) to s. g. and e. s. l. d. g. m. is supported by a grant from the national institutes of health (r01gm104371). j. d. holds a british heart foundation chair, european research council senior investigator award, and nihr senior investigator award. the cardiovascular epidemiology unit at the university of cambridge, which supported the field work and genotyping of promis, is funded by the uk medical research council, british heart foundation, and nihr cambridge biomedical research centre. in recognition for promis fieldwork and support, we also acknowledge contributions made by the following: m. z. ozair, u. ahmed, a. hakeem, h. khalid, k. shahid, f. shuja, a. kazmi, m. qadir hameed, n. khan, s. khan, a. ali, m. ali, s. ahmed, m. w. khan, m. r. khan, a. ghafoor, m. alam, r. ahmed, m. i. javed, a. ghaffar, t. b. mirza, m. shahid, j. furqan, m. i. abbasi, t. abbas, r. zulfiqar, m. wajid, i. ali, m. ikhlaq, d. sheikh, m. imran, m. walker, n. sarwar, s. venorman, r. young, a. butterworth, h. lombardi, b. kaur and n. sheikh. fieldwork in the promis study has been supported through funds available to investigators at the center for non - communicable diseases, pakistan and the university of cambridge, uk .
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example of a second polymorphism in - phase which rescues a putative protein - truncating mutation .
anticipated number of genes knocked out with increasing sample sizes by minimum knockout count .
promis participants have an excess burden of runs of homozygosity compared with other populations .
this file contains supplementary tables 1 - 9, the full legend for supplementary table 1 (supplied as a separate spreadsheet) and supplementary references .
this file contains supplementary table 1 – see the supplementary information document for the full description .
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understanding the function of every human gene is one of the major goals in biomedicine and analysing phenotypes in individuals with loss of function mutations in a particular gene is one way to gain such insight. sekar kathiresan and colleagues systematically examined predicted loss - of - function mutations from sequencing data, making preliminary efforts to investigate their functional relevance through phenotypic association. they sequenced the exomes of 10, 503 individuals living in pakistan and participating in the promis study. they identified 49, 138 rare predicted loss - of - function mutations that are estimated to knock out 1, 317 genes, each in at least one participant, and tested for association with a panel of 201 traits measured in blood samples. the authors demonstrate the usefulness of a reverse - genetics approach, which involves recruiting participants by genotype, and discuss a framework for a human knockout project .
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your wallet says way more about you than where you bank, so invest wisely. here’s our edit of the sleekest, most stylish men’s wallets for every type of spender .
see in the new year 2019, twice, with the most glamorous travel trip in the world. but book quickly as they only have space for 30 people ...
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sometimes the noble art is just plain brutal. here are five of the most crushing ko' s in boxing history. needless to say, the referee didn' t need to count to ten ...
, the buzzer - beating three - pointer, the last - minute penalty and the photo finish all rolled into one. for the boxer delivering it, a knockout is the ultimate kind of victory. for the boxer on the receiving end, the indignity of being added to a highlight reel is every bit as painful as the punch itself. for us, the spectators, meanwhile, a knockout is the climax that makes all the pre - fight hype and foreplay bearable. it is a sporting moment easily understood by one and all. here are five of the best, as chosen by elliot worsell, author of a new book
you know it' s coming home, we know it' s coming home, so why not make some money out of that homecoming with our quarter - final bookie - beating bets ...
worse than a one - punch knockout, this is what happens when a boxer is trapped in the corner and the referee can' t get close enough to save him as things suddenly spiral out of control. it' s as violent as any finish you' re ever likely to see. done and dusted 28 seconds into round five, ray mercer, an olympic gold medallist, bludgeoned tommy morrison, he of rocky v fame, with a couple of cuffing right hands, which left him caught in the corner, and then, with his opponent prone, decided to keep punching – lefts, rights, head shots, body shots – until he cracked morrison' s chin, over and over again, and saw him slump slowly down the ropes and towards the canvas. the referee, tony perez, positioned behind mercer for the duration of the assault could, like everyone else, only stand and watch as morrison' s head lolled and his body melted.
knockouts and knockouts haircuts for men are the trade names of a privately held american salon chain ( international as of early 2011 ) , knockouts llc , based in irving , texas . knockouts are full-service grooming salons with a boxing ( and mixed martial arts ) / sex appeal theme targeting men seeking an alternative to the cut-rate chain salons . the today show ( nbc tv ) , the big idea with donny deutsch ( cnbc ) and other media have compared knockouts to hooters restaurants for the sex appeal/entertainment angle used to engage customers , labeling knockouts “ the hooters of haircutting . ” the salons have a gym/warehouse-like decor with faux boxing ring posts and ropes and a brick wall helping to define the space , as well as boxing photos and memorabilia on the walls . there are flat-screen televisions at each grooming station and in the waiting area . these are usually tuned to sports programs , but are individually controlled by the customer . knockouts employs an attractive all-female staff of licensed hair stylists and massage therapists . the services include haircuts , hair coloring , waxing , manicures , pedicures , and six types of massage therapy . grooming products are also available for purchase . some locations also offer hair replacement and facial shaves . knockouts salons provide a free beverage to customers while they wait , including water , sports drinks and beer ( where legally permitted ) . knockouts has sold over 500 franchised salons in 29 states . 
knockouts and knockouts haircuts for men are the trade names of a privately held american salon chain (international as of early 2011), knockouts llc, based in irving, texas. knockouts are full-service grooming salons with a boxing (and mixed martial arts) / sex appeal theme targeting men seeking an alternative to the cut-rate chain salons. the today show (nbc tv), the big idea with donny deutsch (cnbc) and other media have compared knockouts to hooters restaurants for the sex appeal/entertainment angle used to engage customers, labeling knockouts “ the hooters of haircutting. ” the salons have a gym/warehouse-like decor with faux boxing ring posts and ropes and a brick wall helping to define the space, as well as boxing photos and memorabilia on the walls. there are flat-screen televisions at each grooming station and in the waiting area. these are usually tuned to sports programs, but are individually controlled by the customer. knockouts employs an attractive all-female staff of licensed hair stylists and massage therapists. the services include haircuts, hair coloring, waxing, manicures, pedicures, and six types of massage therapy. grooming products are also available for purchase. some locations also offer hair replacement and facial shaves. knockouts salons provide a free beverage to customers while they wait, including water, sports drinks and beer (where legally permitted). knockouts has sold over 500 franchised salons in 29 states.
knockouts and knockouts haircuts for men are the trade names of a privately held american salon chain (international as of early 2011), knockouts llc, based in irving, texas. knockouts are full-service grooming salons with a boxing (and mixed martial arts) / sex appeal theme targeting men seeking an alternative to the cut-rate chain salons. the today show (nbc tv), the big idea with donny deutsch (cnbc) and other media have compared knockouts to hooters restaurants for the sex appeal/entertainment angle used to engage customers, labeling knockouts “ the hooters of haircutting. ” the salons have a gym/warehouse-like decor with faux boxing ring posts and ropes and a brick wall helping to define the space, as well as boxing photos and memorabilia on the walls. there are flat-screen televisions at each grooming station and in the waiting area. these are usually tuned to sports programs, but are individually controlled by the customer. knockouts employs an attractive all-female staff of licensed hair stylists and massage therapists. the services include haircuts, hair coloring, waxing, manicures, pedicures, and six types of massage therapy. grooming products are also available for purchase. some locations also offer hair replacement and facial shaves. knockouts salons provide a free beverage to customers while they wait, including water, sports drinks and beer (where legally permitted). knockouts has sold over 500 franchised salons in 29 states.