pipex
to host these services, pipex installed the 45gb pipex worldserver, directly connected into the pipex backbone at its main london pop at london telehouse in docklands with more than 17 mb of external connectivity to the pipex network. this makes it the largest commercial public file server in europe .
pipex has a calender of pipex seminars planned for the coming months and the company is regularly invited to participate in user group meets and conferences .
the last of the pipex business - services divisions to bear the company' s name has now been rebranded, after pipex communications became gx networks last week .
pipex itself has expanded through a number of acquisitions in the past few years .
i wouldnt touch aol with a lengthy stick. might go with urltoken or pipex
pipex likes to think of itself as something of a pioneer and is continually working to update and improve the technology of its services. as a result of the development of new hub technology the company was able to announce price reductions for the isdn and analogue dialup services. the new pricing structure for pipex isdn plus, pipex isdn, pipex caller plus and pipex caller services came into effect this january .
british isp pipex is to invest £2 million in subsidising the installation of adsl services .
if the deal gets shareholder approval at an egm later this month then gx networks will change its name to pipex communications plc to make the most out of the pipex brand .
pipex is to pay idt telecom £4m in stock and £20m in cash for the toucan business. pipex gains 185, 000 customers each with an average revenue of £23 per month .
plans are afoot to make additional services available to the pipex international customers and pipex is continuing negotiations to sign up official pipex ips from other countries which currently do not have this level of service, eventually planning to offer a range of services on a truly global scale .
the sale of the division follows a four - month strategic review of pipex by investment bank ubs .
pipex italia is glad to announce his new interactive online stock viewer. click here to visit it .
as the test marketing phase of pipex’s single - user dialup service draws to a close, the company is set to launch the pipex dial package, with a macintosh version of the product already in development .
pipex is also spending £3 million on a marketing campaign to get people to sign up to its deal .
these improvements will bring the total bandwidth from the pipex backbone to other third party networks to over 2. 5 mpbs, with an additional 10mbps to the linx, a uk neutral interconnect based at pipex’s london pop .
early on, many of pipex' s critics said such an approach could not be sustained. however, in the year to the end of may pipex generated £32 million in revenue and notched up pre - tax profits of more than £10 million. as of today pipex also has around £20 million of cash in the bank .
european customers can now contact pipex international partners (ips) to source and support their connections across europe on a local basis. the partners offer the core connections of pipex worldwide plus, and pipex’s isdn and caller services at the same level of service, support, performance and bandwidth as is supplied to the company’s uk customers .
pipex chairman peter dubens said the three services bundle would be offered to all its customers in the coming months .
manufacturer specialized in oem & pipex solutions, offering taylor - made products to cover each client and market needs .
pipex' s residential broadband and landline business was sold to the italy - based communications firm tiscali last july. as part of the deal, tiscali got the right to exclusively use the pipex brand — which derives from the phrase
public ip exchange
— as a result of which the other various pipex businesses have been subsequently rebranding .
the well - established tg2576 mouse model of alzheimer' s disease will be used in the study, pipex said .
vialtus mainly provides hosting and networking services to larger corporations. however, pipex also owned several other web - hosting and business brands — including 123 - reg, webfusion, supanames and donhost — which fell under the umbrella of pipex communications .
the www (world wide web) is the fasted growing area of the internet and to meet this interest, pipex launched a new range of www services last autumn, including pipex worldstore and pipex worldweb. the www is a major way in which companies will be able to buy and sell their wares in the future and is a massive potential marketing tool .
pipex pharmaceuticals, inc. (pipex) is a specialty pharmaceutical company that is developing proprietary, late - stage drug candidates for the treatment of neurologic and fibrotic diseases pipexs strategy is to exclusively in - license proprietary, clinical - stage drug candidates and complete the further clinical testing, manufacturing and regulatory requirements sufficient to seek marketing authorizations via the filing of new drug
pipex dial has been developed as a low cost, turnkey solution for the individual user as a direct response to meet the growing demand for commercial quality internet access services by mobile executives and remote users within large corporates. the pipex dial service also fulfills the need for internet access by small businesses and home users but pipex will meet this market primarily through channel marketing .
has acquired, restructured and consolidated public and private companies, including the formation of two public companies, namely 365 media group plc and pipex communications plc. the 365 media platform consolidated twelve businesses within the online sports information and gambling industry and the pipex
uk internet firm pipex has sold its broadband and phone business to italian rival tiscali for £210m ($ 426. 6m) .
over recent months pipex has joined forces with a string of european internet providers to form pipex international. the formation of this new operation has made the company’s services available to millions of potential customers in many other european countries and means that pipex international is now probably the largest provider of commercial - quality internet services in europe, with access to some 50 pops europe - wide. standard pipex connections are now available in the following countries: belguim, eire, france, germany, luxembourg, the netherlands, slovenia and spain .
pipex web services provide customers with a secure and easy way of setting up their own www pages or ftp server on the internet. the way it works is that pipex effectively ‘leases’ a particular portion of the worldserver machine to each subscriber. to support the service, pipex offers high level consultancy on security and charging mechanisms as well as the design of web pages, so that any customer with a digital pipex connection can post up a wide range of corporate and product information which can be accessed by thousands of users simultaneously .
u. s. firm pipex pharmaceuticals said thursday it has been awarded a government grant to test its alzheimer' s drug coprexa .
the next european upgrade will be the addition of a 128k line into paris to provide access for pipex to yet another neutral interconnect site .
in october 2007, pipex wireless became freedom4, a company which mostly deals with a fixed - wimax service offered as an sdsl alternative in certain areas of the uk, such as milton keynes and manchester. freedom4 has a close reseller relationship with vialtus, formerly known as pipex business .
in response to the expanding applications and varying needs of customers, pipex has been busy making additions and changes to their internet access services offerings .
pipex already supplies many corporates with digital leased lines of 64k, 128k and 256k bandwidth but plans are underway to provide even higher bandwidth connections .
gx networks plc - the telco and business broadband outfit - is to buy pipex for £55 million in shares and cash, it was announced this morning .
the monthly subscription cost of the single user product, pipex xtreme solo 512kbps, has also been priced competitively at £29. 95 (excluding vat) .
the catalog is available online or as download, or in paper by simple request by phone or via our contact page. you will find the dxf - format files (after free registration) in the
downloads
/ pipex - section. the technical pipex - documentation is also available on - line .
e - envoy andrew pinder has backed pipex' s bold move claiming that this initiative will
continue to bring broadband benefits to more businesses and consumers
.
in addition to its pipex brand, the firm also sells internet services under the nildram, bulldog and freedom2surf names - each itself formerly an independent internet service provider .
usinesses within the telecoms and internet industries. 365 media was sold for over £102 million to bskyb and the main operating divisions of pipex were sold for approximately £370 million .
pipex is one of the last big independent broadband providers still to be operating in the uk, following a number of recent deals such as the purchase of plusnet by bt .
the purchase of pipex' s broadband unit - which was put up for sale in march - is expected to lift tiscali' s uk broadband customer base to 1. 9 million .
the organizer of pipex, ppe, has been designated an irs 501 (c) (3) entity. all donations to ppe are tax deductible to the extent allowed by law .
pipex will install their third transatlantic 768k (plus compression) line during march, and this will be integrated into the pipex backbone by mid - april. this third line will give added capacity and resilience to the existing network and, since each of the three lines to the us use different submarine cables, there is no single point of failure in the transatlantic link .
pipex italia, after last year excellent experience on the on - line current stock portal, has presented a major update with three new functions. click on the picture below to learn more :
this is compiled by thousands of responses from actual users of isps. rating based on speed, quality of customer service, and reliability. i' d recommend zen, urltoken or pipex .
said gx networks chairman, peter dubens :
this is an important acquisition in the development of gx networks as it allows us to become cash flow positive immediately and it enables us to rebrand the entire group as pipex, which is one of the strongest brand names in the sector. furthermore, it will improve the mix of products that we sell, as pipex has established a large broadband customer base .
pipex dial enables a company to keep in touch with employees off - site and will even work wth a gsm mobile phone! the package offers full internet ppp (point - to - point protocol) dialup access via the pipex network from anywhere in the uk, using just a portable pc running microsoft windows and a modem, giving about 70% local call coverage. network overheads are minimised by dynamic address allocation which allocates ip numbers on the fly on a session - by - session basis and users can minimise call costs buy dialing into their nearest pipex dialup point of presence (pop), so reducing telephone bills .
the unique structure of the pipex backbone means that there is no single point of failure as the set up is such that there is always a second, or even a third, way for information to run .
david rickards, md of pipex, told the register that 2002 is going to be a big year for broadband in the uk and that the money from its broadband development fund is an investment to attract new customers .
heard good things about pipex, i' m on bt myself, s' ok for what i use it for, certainly haven' t it any of their limits yet, and 2mb for £15 is ok .
but if pipex - which has some 1, 400 broadband customers at the moment - can swell its customer base over the next six months or so as expected then today' s initiative will be looked at closely by other isps .
pipex - which is wholly owned by md david rickards and his family - has been around for 12 years. at the end of june it had around 119, 000 punters - one in ten of all adsl connections in the uk .
keeping pace with the forever increasing growth rate of the internet, pipex has seen a monthly 10% growth in take ups of their connections services, including such names as eurodollar, hm treasury, ibm hursley park, national westminster bank .
pipex has indulged in a little zoological shopping spree, snapping up toucan and bulldog for £24m and £12m respectively. the company says the acquisitions take its customer base to 1. 14m, and its number of broadband subscribers to 570, 000 .
hello and welcome to pipex ltd - trading as pipex px®, leaders in the construction industry, putting award winning engineering and manufacturing at your professional service. our advanced frp composite and thermoplastic products are positively impacting global construction and industrial projects by improving safety and quality whilst extending longevity. we can turn your vision into reality with cutting - edge design & innovation, specialist fabrications & engineering services - building high quality, corrosion free and lightweight pipe systems, chambers, vessels, and structures .
pipex has packet exchange agreements with janet, eunet gb, the ebone european network, the national science foundation network in the us, and full membership of cix (commercial internet exchange), alongside alternet, psinet, eunet, cerfnet, sprintnet and nordunet .
in related news, pipex has also signed a deal with c & w to use the company' s llu (local loop unbundling) access to 800 exchanges. the company says this fits with its policy of using a mixture of its own unbundling and wholesale .
meanwhile, a wholly cash payment of £12m to cable and wireless brings pipex the whole of bulldog' s residential and small business broadband customer base (approximately 100, 000 people, with an average revenue of £34 per month) and rights to the bulldog brand and domain names .
said mr rickards, who will be joining the enlarged company :
we needed an alliance with a larger organisation to take our business to the next stage. gx, with its highly resilient network presence and a culture similar to ours, is the right choice for pipex .
, no obligation advice, for those who want to learn about inherited stamp albums, old family collections or simply find people who know about stamps. our grandma' s attic program brings together local experts with guests who bring their collections to the pipex stamp show searching for information .
... is one of the utmost sales and marketing organizations in the steel pipe industry, operating all over the world. with a 20 years’ experience, we stock and distribute zeleziarne podbrezova products as well as steel goods made by the biggest worldwide companies that complete pipex’ products size range .
coprexa has also completed a one year phase i / ii clinical trial for the treatment of refractory idiopathic pulmonary fibrosis (ipf), a deadly lung disease. pending regulatory feedback on such a study, pipex is planning to launch a phase iii registration clinical for the treatment of ipf with coprexa .
in fact, a recent u. s. study of 3, 718 patients done over six years, showed that subjects who took a vitamin containing a 1. 6 - mg copper supplement, combined with a diet high in saturated fat and trans fat experienced the equivalent of 19 years of mental decline, pipex said .
my problem with pipex is that they dont let you pick your own usernames and passwords, this really annoyed me as i dont want to have to remember some random letter string, i like to have everything how i want it or it gets confusing. i may consider going back though, ill have to do some research
ann arbor, michigan, november 5, 2007 - - pipex pharmaceuticals, inc. (amex: pp) (pipex), a specialty pharmaceutical company developing innovative late - stage drug candidates for the treatment of neurologic and fibrotic diseases, announced the presentation of preliminary results using its lead anti - copper drug candidate, coprexa (oral tetrathiomolybdate), in the most commonly utilized transgenic pre - clinical murine model of alzheimers disease (ad) at the 2007 society for neuroscience annual meeting on november 4 th in san diego, ca. these studies were funded by a grant from the national institute on aging (nia) of the national institutes of health (nih) .
almost a' third' of all uk businesses are now using the inernet in some way, and many more are eager to connect up over the coming months. these are results of research commissioned by pipex from a leading hi - tech research company in november 1994 into the way large companies are using, or planning to use, the internet over the next 12 months .
privacy policy | cookie policy share capital: € 258. 000, 00 fully paid up milan companies register tax code & vat registration n° it11027910154 societá soggetta a direzione e coordinamento di zeleziarne podbrezova a. s. (repubblica slovacca) copyright © pipex italia s. p. a. 2018, all rights reserved | webdesign & hosting by žp informatika s. r. o .
mike has over 30 years' experience in the global telecommunications, media and technology (tmt) sector and has been a director of eight public companies. he has held numerous' c' level roles in the uk and usa, including ceo of pipex communications, executive director at daisy group plc, non - executive director at nasstar plc, and non - executive chairman at inty ltd .
pipex dial gives full internet access and installs in just a few minutes. it includes the new ppp kernel from ftp software, netscape 1. 0 browser for www and usenet access, mail - it email package, telnet and ping utilities and a pop mailbox for sending and receiving mail. the service costs £50 set up with an annual fee of £180 (£15 / month), plus vat .
steve h. kanzer, chairman & chief executive officer of pipex, commented, since the serendipitous finding of dr. larry sparks in 2003 that free copper in the drinking water of high cholesterol - fed animals plays an important role in the formation of alzheimers - like disease, the last four years has witnessed a tremendous body of collaborating evidence implicating free copper in the pathogenesis of ad. these studies have taken
coprexa is an oral, small - molecule, anti - copper agent that is highly specific for the reduction of free copper in serum, the most toxic form of copper in the body, and is thus ideally suited for the treatment of central nervous system (cns) diseases in which abnormal serum and cns copper homeostasis are implicated. coprexa has completed pivotal clinical trials for the treatment of neurologically presenting wilsons disease, an orphan disease of the cns, and pipex plans to file an nda with the fda for this indication during this month, november 2007 .
ann arbor, mi - - (marketwire - may 20, 2008) - pipex pharmaceuticals, inc. (amex: pp), a specialty pharmaceutical company developing innovative late - stage drug candidates for the treatment of neurologic and autoimmune diseases, announced it was issued a united states patent that is part of its cd4 inhibitor patent estate. the issued patent, u. s. 7, 345, 020, entitled ,
mimetics of cd4 that inhibit immune responses ,
covers new chemical entities relating to inhibitors of the highly studied cd4 t - cell receptor, a key protein in t - cell - antigen presenting cell immunological synapse formation and t - cell activation critical in so - called cd4 - mediated diseases such as transplantation, multiple sclerosis (ms), psoriasis, and rheumatoid arthritis (ra) .
the form of human dietary copper epidemiological studies in the elderly, post - mortem pathology studies of human amyloid plaques and their co - localization with copper, comparative human studies finding elevated levels of serum free copper in ad patients compared to age - matched controls, as well as many molecular studies establishing free coppers high binding affinity and oxidizing effects on the majority of recognized ad - related proteins, including, amyloid beta, tau, amyloid precursor protein (app), beta secretase, and apolipoprotein e (apoe) phenotypes 2 / 3 / 4. references (1 - 9). taken together, this mounting body of evidence implicates elevated free copper levels in the central nervous system as a consistent and prominent cause of the characteristic copper - containing insoluable amyloid beta plaques, neurofibrillary tangles, cognitive impairment and neurodegeneration that defines ad. as a society in which 50% of our population over the age of 75 are already afflicted by ad and countless others at risk of developing ad, ad is the disease of our time, and it is high time that we pay attention to the risks that free copper poses to our susceptible elderly population (especially those at genetic risk for ad) and pursue with vigor potential therapeutic interventions such as those that our company is developing that specifically aim to lower the central nervous system copper burden of already affected patients. the experiments conducted and results presented by dr. joseph quinn and colleagues at oregon health & science university represent the first prospectively defined controlled therapeutic intervention study in mice or man that is specifically targeted to lower free copper levels in the central nervous system for the purpose of treating ad and the results demonstrate that lowering such free copper can lower insoluable amyloid beta levels by 40% . and thus a disease modifying effect in ad. ohsus efforts and results would not have been achieved without the support of the national institute on aging to whom pipex would like to take the opportunity to thank. we look forward to the further results of dr. quinns group regarding their ongoing additional cohorts of transgenic tg2576 animals currently being tested pursuant to a protocol in which coprexa is being administered to animals after the typical apparent onset of disease at 10 - 12 months of age. 
the changes you notice will be minor: a different company name will appear on the bottom of our website and on messages we send to you, and charges on your bank account or credit card may appear under the new company name ,
read an email from 123 - reg to its customers on saturday .
day to day, it is business as usual here. the team behind 123 - reg isn' t changing and you won' t notice any difference to your 123 - reg services .
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an $ 18m supercomputer to simulate brains of mice in the land of swiss cheese. how apt, hpe
hardware rumours, goat - spanking search engines and plenty of azure. it' s last week in redmond
microsoft might not support windows xp any more, but gandcrab v4. 1 ransomware does
cops suspect detroit fuel station was hacked before 10 drivers made off with 2. 3k' free' litres
git365. git for teams. quatermass and the git pit. github simply won' t do now microsoft has it
imagine a patent on organizing computer files being used against online shopping sites. oh, it' s still happening
ai bots suck at marking written essays, not too shabby at old atari games, and more ...
more importantly, they also mean the company has a so - called triple play offering, the combination of mobile, voice and broadband services widely seen as key to success in a rapidly shifting and much tougher market .
this paper explores plaster - the seven major ai challenges - in the context of nvidia’s dl solutions .
to support existing power systems customers, and to address the needs of new customers seeking to expand their cloudhosting capabilities, ibm has announced two new families of cloud - ready power8 - based servers .
the 3 key challenges: managing overwhelming amounts of data, leveraging new complex tools / technologies, and developing the necessary skills and infrastructure .
help! our virgin media tivo boxes are stuck in a loop! help! our virgin. .
have you tried turning it off and on again? oh, it' s already doing that... again and again
the register - independent news and views for the tech community. part of situation publishing
part of its success as a broadband isp was its willingness to spend cash up front to attract punters, combined with competitive monthly subscriptions which undercut the big boys such as bt and aol .
last month, gx networks bought firstnet services ltd - the company that acquired fixed wireless broadband outfit liberty broadband (aka tele2 uk) earlier this year - for £4. 3 million .
the deal means that gx networks has now added wireless broadband to the stable of products it can supply punters .
in july, gx networks acquired xtml limited and compulink information exchange limited, which were previously part of the telenor business holdings uk limited group .
in october last year zipcom acquired transigent through a reverse takeover before changing its name to gx networks plc in march 2003. ®
today, business users need on - the - go access to all their critical data, which includes emails, documents and attachments .
spectrum cdm is a new addition to the ibm spectrum data protection portfolio. it is designed to enable non - protectionrelated use cases for secondary data .
how advanced ai applications require a modern all - flash storage infrastructure that is built specifically to work with high - powered analytics, helping to accelerate business outcomes for data driven organizations .
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urltoken
tiscali also unveiled a first - half core profit of 60m euros (£40. 7m; $ 82. 7m), up 45% on last year .
the prospect of a sale has therefore been closely watched by rivals such as bt, bskyb and virgin media .
in march 2006 it bought the homecall voice and line rental business from phones4u for £44m. it has also acquired toucan from idt telecom and bulldog' s broadband customers from cable & wireless .
the company also used baywatch star david hasselhoff in a recent advertising campaign to attract customers .
most popular now | 56, 514 people are reading stories on the site right now .
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most popular now | 17, 029 pages were read in the last minute .
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aimed primarily at residential users, the move is designed to kick - start the uk' s fledgling broadband market .
the money will be used to cover the installation costs for 40, 000 new customers who sign up to a diy self - install adsl product .
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urltoken
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- clamping system. fastening for plumbing facilities, heating, cooling, ventilation, ...
more than 15 years' experience, customers worldwide, high manufacturing capacity and all the main quality certifications .
sanitary water and heating plumbing pex - a leader commited to a continuous research + development + improvement philosophy .
auray managing, s. l. - carrer mercaders 4 - p. i. riera de caldes - 08184 palau solità i plegamans (barcelona) - tel. 937 481 036 - info @ urltoken
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the app allows you to convert imperial unit to metric units for a wide variety of steel tubes. it also includes useful formulas for costing and technical specifications .
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urltoken
to allow us to keep that arrangement, please consider making a donation to portland philatelic exhibitions (ppe) .
© 2017 partners in performance exce llence. all rights reserved. (781) 801 - 6893 info @ urltoken
the results show that email is still seen as the most useful internet tool and corporate users still view improved com - munications with employees, customers and suppliers as the most important benefit that internet access gives. however, the sourcing and provision of information, and file transfer capabilities are gaining recognition and growing in importance as ways of improving business opportunities and efficiency .
the corporate internet community continues to outweigh the academic and home user sector, and all sectors look set to increase dramatically over the next twelve months. according to input, the global it market intelligence firm, by the year 2000, the population connected to the internet will grow to more than 200 million and business - to - business electronic commerce volumes transacted over the internet may reach $ 75 billion worldwide (business first, 19 dec 94) .
in case you’ve forgotten, here’s a reminder. the company provides full commercial internet connectivity via a range of dialup and high bandwidth leased line sevices, giving access to email, file transfer, remote login and online information services worldwide .
all the above + vat. call charges are met by the customer but analogue customers are connected to their nearest pop to minimise costs .
oakley capital was founded in 2002 by peter dubens and david till to make private equity investments in mid - market companies, located predominantly in western europe .
in 2007, the first fund was raised and peter launched oakley capital private equity with david till, to be an entrepreneurially - driven uk investment house, encouraging and backing entrepreneurship. to that end, oakley capital private equity, invests in and supports the continued growth and development of some of europe’s leading companies, including the global multimedia platform time out; the iconic sailing brand, north sails; facile, italy’s leading price comparison website; and parship elite group, a leading online dating company .
unusually in mid - market private equity, oakley is a firm founded by an entrepreneur from the business community, rather than a spin - out from a larger financial institution .
oakley capital limited. a limited company registered in england and wales (company number 04091922) with its registered office at 3 cadogan gate, london, sw1x 0as. authorised and regulated by the financial conduct authority (number 195029 )
fca cobs rule 2. 2. 3r requires fca authorised firms to disclose whether they conform to the requirements of the uk financial reporting council’s stewardship code (the “code”). adherence to the code is voluntary. while the oakley capital group supports the principles of the code, it does not consider it appropriate to conform to the code at this time .
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the free api is limited to 1, 000 daily requests and returns city level location data only, if you require larger query volumes or more information such as latitude / longitude, isp details or threat level assessment, please see our commercial offers .
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joseph quinn, m. d. , associate professor of neurology at oregon health & science university (ohsu) and primary investigator of this study commented ,
these preliminary results of a significant reduction in central nervous system copper (p < 0. 05) and a 40% reduction in insoluble amyloid beta (p < 0. 05) are encouraging from a standpoint of coprexas ability to be a potentially disease modifying therapy for ad. these preliminary results need to be replicated and expanded before we proceed to clinical trials. 
dr. george brewer, professor emeritus at the university of michigan and inventor of coprexa, said, the strength of the association between coppers causative relationship and alzheimers disease parallels my experience in treating neurologic wilsons disease, a disease of similar neurodegeneration. while a different form of disease, in coprexa treated neurologic wilsons disease, we have seen a reversal or improvement in the neurologic scores of these patients. currently, there are no adequate approved or disease modifying treatments for alzheimers and these results represent an important step forward for the 4. 5 million americans suffering from alzheimers .
over the last several years, an increasing body of evidence points to dysfunctional copper homeostasis in the pathogenesis of ad. most recently, a published observational six year study in 3718 patients over the age of 65, concluded that subjects that consumed a typical amount of a copper supplement (1. 6mg of copper a day) when taken together with a high saturated and trans fat diet results in an equivalent of 19 years of mental decline (p < 0. 001) (2) .
in a separate european clinical study conducted in 53 patients, correlated the levels of the highly reactive free copper (also known as copper not bound to protein) pool in serum to disease severity in ad patients versus aged - matched control patients. these results demonstrated that the free copper serum pool was highly increased in ad patients (4) .
these clinical studies are complemented by preclinical studies that show that ad amyloid - ß plaques when treated with copper chelating agents in vitro loosen and reverse fibril formation as determined by spectroscopy .
in the experiments conducted at ohsu, two separate groups of animals, transgenic tg2576 app overexpressing mice and wild type controls were each randomized to receive orally administered coprexa or control vehicle (4 cohorts, 6 animals per cohort) for a period of 6 months beginning at 8 months of age, approximately 2 months prior to the typical onset of ad - like pathology. animals were sacrificed at 14 months of age and brain homogenates were then compared and quantified for the levels of soluable (nonpathogenic) amyloid beta and insoluble (pathogenic) amyloid beta. in the tg2576 animal cohorts, a statistically significant 20% reduction in brain copper levels was observed as well as a statistically significant 40% reduction in insoluable amyloid beta between the tg2576 animals receiving vehicle as compared to the tg2576 animals receiving coprexa. while statistically significant reductions in brain copper and insoluable amyloid beta were achieved in the current studies in transgenic tg2576 app overexpressing mice, the small sample size of the study appears to have been insufficient to demonstrate conclusive change in special memory and learning scores both between and among control and treated and transgenic and wild type groups of animals pursuant to standard morris water maze experiments of special memory .
subject to initial and necessary registration clinical trials to support its use in treating ad, coprexas specificity and unique mechanism of action for lowering toxic free copper levels in the cns, combined with its history of success in completed pivotal clinical trials of neurologically - presenting wilsons disease, may make it highly useful in the treatment of both the acute cognitive dysfunction (copper - mediated synaptic excitotoxicity) as well as long - term neurodegenerative aspect (copper - induced oxidation and neuronal death) of ad coprexas ability to specifically bind only toxic free copper, as opposed to increasing free copper levels by virtue of liberating bound copper, for example, amongst other properties, we believe differentiates oral tetrathiomolybdate from other non - specific metal chelating compounds previously investigated for neurodegenerative diseases .
it is estimated that more than 4. 5 million americans and 12 million people worldwide suffer from ad. risk factors for the disease include age and family history. age is the most important risk factor for ad; the number of people with the disease doubles every five years beyond age 65. according to the alzheimers association, the disease affects one in 10 persons over the age of 65, and 50% of those over 85 years old .
there is an urgent need for an effective treatment for the illness, caused in part by the rising health care, institutional, and social costs for the treatment and care of alzheimers sufferers. in may 2002, the national institute on aging (nia) reported that the cost of care to family, caregivers and society in general was estimated to exceed $ 100 billion per year, up from $ 18 billion in 1996, ranking ad as the disease with the greatest economic cost to society. these costs are expected to rise sharply as the baby - boom generation ages and more people become at risk for the disease. as people live longer, their risk of developing ad increases .
the market for treatment of ad is equally large, accounting for $ 3 billion in worldwide sales in 2004. this market is expected to grow to $ 5 billion by 2009. aricept ®, an fda - approved acetylcholinesterase inhibitor, is the top - selling treatment, accounting for 40% of the alzheimer' s - drug market in 2004 with $ 1. 35 billion in sales and year - over - year revenues growing by 17% per annum. these sales figures would be expected to grow upon the introduction of a disease modifying therapy for ad as no disease modifying therapy is currently commercially available .
we are also developing coprexa for fibrotic disorders based upon the rationale that the fibrotic disease process is dependent upon the availability of free copper in the body. coprexa has demonstrated the ability to inhibit fibrosis in a number of well established animal models through the sequestration of available copper and inhibition of key fibrotric cytokines, including secreted protein acid rich in cysteine (sparc), nf? b, tgf - ß, fgf - 2, il - 1, il - 6, il - 8, and connective tissue growth factor (ctgf) .
sparks dl, schreurs bg, trace amounts of copper in water induce beta - amyloid plaques and learning deficits in a rabbit model of alzheimer' s disease. pnas 100 (19): 11065 - 9 (2003) pubmed id: 12920183
morris et al. , dietary copper and high saturated and trans fat intakes associated with cognitive decline. , arch. neurol 63: 1085 - 1088; (2006) pubmed id: 16908733
miller lm et al. , synchrotron - based infrared and x - ray imaging shows focalized accumulation of cu and zn co - localized with beta - amyloid deposits in alzheimer' s disease. j struct biol 155 (1): 30 - 7 (2006) pubmed id: 16325427
squitti et al. , excess of serum copper not related to ceruloplasmin in alzheimer disease. neurology 67: 76 - 82; (2006) pubmed id: 15781823
syme d et al. , copper binding to the amyloid - beta (abeta) peptide associated with alzheimer' s disease: folding, coordination geometry, ph dependence, stoichiometry, and affinity of abeta - (1 - 28): insights from a range of complementary spectroscopic techniques. j biol chem 279 (18): 18169 - 77 (2004) pubmed id: 14978032
ma qf et al. , binding of copper (ii) ion to an alzheimer' s tau peptide as revealed by maldi - tof ms, cd, and nmr. biopolymers 79 (2): 74 - 85 (2005) pubmed id 15986501
barnham kj et al. , structure of the alzheimer' s disease amyloid precursor protein copper binding domain. a regulator of neuronal copper homeostasis. j biol chem 278 (19): 17401 - 7 (2003) pubmed id: 12611883
angeletti b et al. , bace1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase - 1 and binds copper. j biol chem 280 (18): 17930 - 7 (2005) pubmed id: 15722349
miyatam, smith jd, apolipoprotein e allele - specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta - amyloid peptides. nat. genet. 14 (1): 55 - 61 (1996) pubmed id: 8782820
the specialty pharmaceutical company said it has received $ 306, 172 from the national institute of health' s national institute on aging to conduct a mouse study of its anti - copper agent coprexa to treat alzheimer' s disease .
one group of mice in the study will be given the drug before the formation of the brain plaque associated with alzheimer' s disease, to determine if coprexa can prevent the disorder .
the study will build on an increasing body of evidence that so - called
free copper
- - or copper not bound to proteins - - in blood serum is a key marker in alzheimer' s disease .
july 9 (upi) - - a new report shows clot - busting drugs can prevent thousands of strokes per year, as researchers found 4, 000 were prevented in england in 2015 and 2016 alone .
july 9 (upi) - - researchers have designed a prototype smart bandage that can monitor chronic wounds and deliver medication aimed at improved healing .
july 9 (upi) - - rectal cancer patients under 50 don' t see an improvement to their overall survival after receiving recommended treatments, researchers found in a study .
bristles can break off and stick to the grill and cooked food, posing a serious health risk, according to the american medical association .
an experimental hiv vaccine was safe and triggered strong immune responses in healthy adults and in monkeys, researchers report .
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i know there have been similar threads before and i' m sure a lot of people are bored of giving these types of answers, but... i' m now realising i really need to change to broadband, i seem to be using my computer much more nowadays especially for uploading for my website and now uploading images to' upixa' (see other thread in lounge !) .
im looking for similar, without any upload / download caps, i. e must be true inlimited download .
surely that' s only the master account though - you can choose usernames for other mailboxes. besides, if accessing on your own home computer, the passwords are best remembered by your mail client .
and, apart from last week when they had problems with a major network reorganisation, i' ve been happy with them. cheap because you pay upfront, no bandwidth restrictions, unlimited mailboxes, etc. mention my name and i' ll get a £20 referral fee !
whats wrong with aol? i' ve used aol dailup and now onto broadband (silver) and haven' t had any problems with them. unlimited download etc. . i don' t think they are the cheapest around - but i never get any spam in my inbox. i never use (well hardly ever) use the aol browser tho', prefer firefox .
well... when they bought out compuserve, all of the customer information that was held by compuserve suddenly became available to 3rd parties who wanted to buy the info .
just like all your' private info' that aol have on you. they are very well known for selling on your details to any interested parties .
that' s nice of them. . might change after my years contract is up, pain about my email address tho'. whats gmail like (anyone have it here, as you can' t register - only be invited i wouldn' t mind trying it )
im not bothered about email accounts, webspace or anything as i have that seperately .
that' s nice of them. . might change after my years contract is up
you' re going to have lots of fun trying to remove the software from your computer .
i am with demon. no limits, 2mb speed never a problem, joined just over a year ago. just what it says on the tin. adsl home 2000 £17. 01 month + vat terry
- 1, 700, 000 matches. lots of people i know can' t bear it, and i must admit i tried it once and wouldn' t want to pay for it. i had first hand experience of their customer service last year too, and that was abominable.
pipex was the united kingdom 's first commercial internet service provider ( isp ) . it was formed in 1990 and helped to develop the isp market in the uk . in 1992 it began operating a 64k transatlantic leased line and built a connection to the uk government 's janet network . one of its first customers was demon internet which popularised dial up modem based internet access in the uk . it was also one of the key players in the development of the london internet exchange through a meeting with bt in 1994 . the company went through a number of mergers and acquisitions and by 2007 had dropped to be the sixth largest isp in the uk . the pipex name was used by a number of companies within the group , which were gradually renamed following the sale of its home broadband business to tiscali uk in 2007 . in 2009 , the former pipex wireless business , rebranded as freedom4 , bought the former pipex business , known as vialtus . freedom4 also purchased daisy group through a reverse takeover , and the three companies were brought together as daisy . 
pipex was the united kingdom's first commercial internet service provider (isp). it was formed in 1990 and helped to develop the isp market in the uk. in 1992 it began operating a 64k transatlantic leased line and built a connection to the uk government's janet network. one of its first customers was demon internet which popularised dial up modem based internet access in the uk. it was also one of the key players in the development of the london internet exchange through a meeting with bt in 1994. the company went through a number of mergers and acquisitions and by 2007 had dropped to be the sixth largest isp in the uk. the pipex name was used by a number of companies within the group, which were gradually renamed following the sale of its home broadband business to tiscali uk in 2007. in 2009, the former pipex wireless business, rebranded as freedom4, bought the former pipex business, known as vialtus. freedom4 also purchased daisy group through a reverse takeover, and the three companies were brought together as daisy.
pipex was the united kingdom's first commercial internet service provider (isp). it was formed in 1990 and helped to develop the isp market in the uk. in 1992 it began operating a 64k transatlantic leased line and built a connection to the uk government's janet network. one of its first customers was demon internet which popularised dial up modem based internet access in the uk. it was also one of the key players in the development of the london internet exchange through a meeting with bt in 1994. the company went through a number of mergers and acquisitions and by 2007 had dropped to be the sixth largest isp in the uk. the pipex name was used by a number of companies within the group, which were gradually renamed following the sale of its home broadband business to tiscali uk in 2007. in 2009, the former pipex wireless business, rebranded as freedom4, bought the former pipex business, known as vialtus. freedom4 also purchased daisy group through a reverse takeover, and the three companies were brought together as daisy.