not a pretty picture
this story' not a pretty picture': accc puts new car industry on notice first appeared on the sydney morning herald .
pretty little liars lead lucy clocks in at 5ft 2. picture: james white / abc family via getty images
when you think of the fact cars are the second - biggest purchase any consumer makes... it' s not a pretty picture ,
mr sims said .
skopje, macedonia (ap) — the scene was the super cup against real madrid, and it wasn' t a pretty picture for marouane fellaini .
this pop legend has a height of 5ft 8. not let his array of hats deceive you. picture: getty
pop sensation, riri comes in at a tall 5ft 8. picture: getty
' sorry' bieber, you' re 5 ft 9. not quite 6 ft. picture: pa
reality tv queen kim k is just 5ft 2 tall. a small lady with a big showbiz empire! picture: getty
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merz jf, cho mk. disease genes are not patentable: a rebuttal of mcgee .
this cheeky chappy looks fairly happy with his height of 6ft. picture: pa
everybody' s favourite singing sensation nathan sykes beats the hunky zac efron by an inch... come on boys, it' s not a competition! picture: pa photos
the youngest jenner measures 5ft 6. don' t be fooled by her average height - this jenner is not to be messed with! picture: instagram
the ex jonas - brothers singer comes in at 5ft 9. picture: pa photos
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one part of the worlds biggest boybands, harry styles measures 5ft 11. picture: pa
queen beyonce might wear heels a lot but she isn' t fooling us. she' s 5ft 7! picture: getty
a man known for his rants and larger than life personality, kanye west is of average height at 5ft 8. picture: splash
the perfect size for the red carpet, adam levine comes in at 6ft. picture: getty
the original princess of pop, ms britney spears herself, is 5ft 4. picture: pa images
in the video, featuring all of the usual touchstones of all previous versions of fargo — snow, police cars, midwestern accents, sudden violence — we also meet the new cast, consisting of carrie coon (from the leftovers), mary elizabeth winstead, david thewlis, coen veteran michael stuhlbarg (from a serious man) and, playing two different characters, ewan mcgregor. it’s “not a pretty picture, ” coon’s character warns .
pankaj sekhsaria has been writing about the andaman and nicobar islands in the mainstream media for years now and in this book presents a collection of those articles—and a couple of academic papers. put together, these provide the lay reader with a bird’s eye view of the state of affairs in these exotic and beautiful (and often marginalised) islands: the picture that emerges, alas, is often not pretty at all. the book has been excellently organised with section headings dealing with different issues and aspects .
the' roar' singer measures 5ft 7, despite the killer shoes she often wears. picture: pa
she means business in both her dress sense and height - jennifer lawrence is 5ft 9. picture: getty
legs that go on for days... which is why she is a supermodel. kendall jenner comes in at 5ft 10. picture: getty
she' s hotter than hell and she' s insanely tall too! well, she is a model as well as a popstar. we' re talking 5ft 10 people. picture: instagram
the' lush life' superstar comes in at a modest 5ft 6. how comes they always seem so much bigger on stage? ! picture: pa
our movie star favourite, zac efron measures 5ft 8. that' s tall enough for us! picture: getty
across the board, the accc found consumers were not being issued adequate information about consumer guarantees during the point of sale of a new car .
this hungarian film is a careful, compassionate and beautifully acted character drama with a social conscience .
the ‘heart attack’ star is fiery and larger than life - well, technically she’s only 5ft 1. # justsaying picture: pa
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no wonder all the ladies swoon over the 50 shades of grey frontman, jamie dornan. he' s 6ft! picture: getty
the sense of place is as pervasive as a character in “moss, ” a film by daniel peddle .
mother monster lady gaga is one of the smallest pop stars of them all at just 5ft 1. but she' s got a very big personality - as we all know! picture: getty
in this pitch - black icelandic farce, a suburban feud over a lovely old tree threatens to destroy two families .
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no wonder she' s the leader of the pack - she' s the tallest of them all! taylor swift measures 5ft 10. picture: getty
“we are one of the problems but certainly not the only ones, ” said blick chief executive bob buchsbaum of his 65 - store chain. “it’s a challenging time for all retail. ”
open recommends firefox 30 +, google chrome, safari 7 + and internet explorer 9 +. other browsers may not display pages properly .
right now you have a chance of not getting your consumer rights, paying too much for servicing and getting false information about your fuel economy... this report is meant to change the game .
opposition to a diagnostic use exemption is more understandable, since there may be unusual situations in which exclusivity is needed to get a product or service to market, and such situations were simply not captured in the cases studied to date. nevertheless, it is quite clear that in many if not most cases of genetic diagnostics, the main use of university exclusive licenses has been to reduce competition and reduce the number of laboratories offering tests, without apparent benefit of introducing tests that were not already available, and would demonstrably have been available even without the participation of the companies involved .
it could have been a cheap knockoff, and not measured up to the film in so many different ways. but the fargo tv show has pretty much thrown a no - hitter so far. the first season — with billy bob thornton and martin freeman as criminals and allison tolman as the gundersonesque cop chasing them, was outstanding. the second season, which took the action back to the late ‘70s with a cast led by patrick wilson, kirsten dunst, and jesse plemons, was even better. and now the third season is about to debut, featuring yet another all - new cast. fx - - following several outstanding teasers for the new season — has released a 30 - second “cast spotlight” video featuring the show’s latest new cast .
the hunger games star comes in on the small side at 5 ft 7 when compared to his co - stars. he' s the same size as beyonce! picture: pa
a young woman photographer engaged to be married to a businessman investigates a cult in the local club scene. by living out some of her sexual fantasies she faces the truth about her life and helps one of the cult' s victims escape .
enjoy a night in with these popular movies available to stream now with prime video .
ruth wilson gives a tough, traumatized performance in clio barnard’s yorkshire - set psychodrama .
rai a. regulating scientific research: intellectual property rights and the norms of science .
overwalle gv. the implementation of the biotechnology directive in belgium and its after - effects. the introduction of a new research exemption and a compulsory licence for public health .
a semi - autobiographical docudrama about rape by martha coolidge in which she reconstructs her own rape at age 16, when a high school date with an older boy turns violent .
a new documentary argues for the unhappy life of whitney houston, who died in 2012 .
centre for intellectual property policy / health law institute; montreal: 2005. et a .
‘uptown funk’ singer bruno is also on the smaller side with a height of 5ft 5 .
carrie coon stars as gloria burgle, the steady chief of the local police department. a newly divorced mother, gloria is trying to understand the new world around her, where people connect more intimately with their phones than with the people around them. mary elizabeth winstead stars as ray’s girlfriend, nikki swango, a crafty and alluring recent parolee with a passion for competitive bridge. david thewlis stars as v. m. vargas, a mysterious loner and true capitalist whose bosses plan to partner with emmit, whether the parking lot king likes it or not .
the market study homed in on the complaints handling systems of manufacturers that do not to comply with obligations under australian consumer law, while calling for more accurate information about emissions and fuel consumption .
let' s face it, it doesn' t matter how tall you are when you' re responsible for anthems such as' pass out' and' girls like'. but tinie stands at 5ft 8. picture: pa photos
there is a specific issue with the facebook in - app browser intermittently making requests to websites without cookies that had previously been set. this appears to be a defect in the browser which should be addressed soon. the simplest approach to avoid this problem is to continue to use the facebook app but not use the in - app browser. this can be done through the following steps :
because of the limited nature of the myriad - nci mou, its value as a precedent is limited. it covered only the provision of services by myriad. it did not address the general question of which research practices a patent holder should tolerate in the diagnostics field. some of the conflict surrounding patents and genetics laboratories could be avoided by adopting a clearer definition of research for purposes of incorporating licensing terms to ensure low threat of patent infringement liability. the scope of government use rights under the bayh - dole and stevenson - wylder acts is another legal gray zone. in any case, the definition of research should not be left to the individual negotiation between one company and one nih institute. the nih could play a key role in developing this norm by convening a meeting of interested parties to develop the principles by which individual actors can determine how to apply the norm .
paul rudd, evangeline lilly and a host of other familiar faces join this latest marvel adventure .
from a producer of “your name, ” “fireworks” doesn’t realize its potential, our critic writes .
schissel a, merz jf, cho mk. survey confirms fears about licensing of genetic tests .
mixing narrative and documentary filming in a unique way the story is autobiographical and is about a date rape dissecting the characters and circumstances around it. by following the... see full summary »
one prominent example of disputed norms is the controversy between myriad genetics and the university of pennsylvania genetic diagnostic laboratory (gdl). while myriad states that it is generally supportive of research, it nevertheless sent gdl a cease - and - desist letter since it did not consider gdl' s activities to be research. to myriad, gdl' s provision of testing services to researchers was commercial, not a research service. 14 gdl took the position, however, that its activities, which supported others' research, fell within the norm of tolerated research use, and much of the contested testing was part of clinical trials funded by the national cancer institute, which is clearly clinical research. much debate ensued, leaving many researchers with the (wrong) impression that myriad would not tolerate any form of research .
he said new cars were not only made up of mechanical parts, but
over 10 million lines of computer code
, more than that used to operate on - board support systems of modern airliners .
universities that provide diagnostic testing services face private genetic testing companies that enforce patents against university genetic testing services and national reference laboratories 5 – in contrast to the situation for therapeutics, where universities are often the plaintiffs. the story often begins with publicly funded academic or non - profit research that is either patented and licensed exclusively to a private company or forms the basis for a spin - off company that attracts further investment and develops an invention that is patented. whether exclusive licensees or spin - offs, these companies then develop genetic testing services based on a business model that relies not only on patenting sequences and mutations – not objectionable in itself – but also on preventing other institutions, including universities from offering those genetic tests .
it’s a ridiculous movie, but jackie chan is still the most talented and witty athlete in cinema .
“this is congo” aims to deliver a portrait of the democratic republic of congo from the ground up .
despite their brevity, these sort of commercials give us a sense of who these characters are. hawley writes such good dialogue we only need to hear a single line from a character to know what they’re all about. you can see more of his latest characters in some new photos from fargo season 3 :
merz jf, cho mk, robertson mj, leonard dg. disease gene patenting is a bad innovation .
tall enough to protect his pocket sized other half in comparison, liam hemsworth is a giant 6ft 3 .
patent incentives may induce investment in genetic diagnostics, but in none of the case studies did this lead to new availability of a test that was not already available, at least in part. this is in stark contrast with the role of patents in therapeutics and scientific instrument development, where the benefits attributable to private r & d and new products are much clearer. the case studies thus reinforce the wisdom of the nonexclusive norm for licensing genetic diagnostics, unless an unusual situation arises in which exclusivity is needed to get a product to market for the first time. the cases also highlight deviations from the nih best practices, oecd guidelines and nine points. exclusive licensing practices consistently reduce availability, at least as measured by number of available laboratories offering a test, and thus reduce competition in genetic diagnostics, but with little evidence of a public benefit from services not otherwise available .
a. i. friedman’s store and warehouse closing will put 27 people out of work, according to a state filing. the store didn’t return calls for comment. industry insiders say it’s been struggling to pay vendors .
it highlighted a dominant
culture of repair ,
a focus on warranty obligations in place of consumer guarantees and widespread use of non - disclosure agreements when resolving complaints as key issues for consumers trying to enforce their rights .
there are a few other pivotal characters we’ve yet to clearly see in the promotional materials for fargo, which makes sense considering how large the cast is and how short these ads are. this season co - stars jim gaffigan (gloria’s deputy), scoot mcnairy (a criminal and a stoner), shea whigham (meeker county’s chief of police), and me and earl and the dying girl ‘s thomas mann (a science fiction writer) .
news corp. is a network of leading companies in the world of diversified media, news, and information services .
the market study also found consumers were not being given accurate information about the fuel consumption of new cars, citing research from the australian automobile association that indicated real - world fuel consumption is on average 25 per cent higher than official laboratory test results .
the two most controversial sacghs recommendations have been (1) a proposed exemption from infringement liability for research use and (2) a similar exemption for diagnostic use. as previously noted, university licensing offices opposing a research exemption puts them at odds with their own stated principles, since licensing to ensure freedom to do research appears in every document proposing norms for licensing .
and the tallest of them all goes to... . the rock who comes in at a massive 6ft 5 !
fx’s fargo anthology tv series is such an unlikely success that it’s practically a miracle. it takes the 1996 joel and ethan coen film fargo, and borrows the name, setting, themes, and visual style, and while it’s set in the same universe, it features not a single one of the movie’s actors or characters. and the coens, who wrote, directed, produced and even edited the movie, aren’t involved in the show at all; legion creator noah hawley is the showrunner .
participants at the april 2009 duke workshop noted that most licensing information is not publicly available, even for inventions arising from public funding. in some cases, but only some, it is possible to reconstruct licensing terms from company annual reports or from press announcements. there is often no way for researchers and institutions to know what practices a license covers, whether there remains scope for others to practice an invention, which regions it covers and whether it applies to any specific fields of use or contains special restrictions. the lack of information makes it difficult to substantiate claims that licensing practices are changing or comply with best practices. as a study 11 on university licensing practices notes, simply stating whether a license is exclusive or non - exclusive misses important nuances. not only would more transparency help researchers better understand the scope and ownership of intellectual property rights but it would also allow policy makers, academics and ttos to determine in what cases exclusive licensing is justified as opposed to a blanket norm of non - exclusive licensing .
while most industries tolerate a broad range of research activities and most researchers ignore patents when deciding whether to do research, 56 such blithe ignorance is not an obvious option in human genetic diagnostics where threatened enforcement is common, laboratory directors and clinicians tend to respond to threatened enforcement by ceasing those activities and where workarounds in the case of method patents are not always available. 49 norms over what research is to be tolerated are unsettled despite the existence of research exceptions 57 in many national laws (including an exemption in the united states with respect to products that may eventually lead to the filing of an application with the food and drug administration 58) .
much university research relates to basic research, including research into scientific principles and mechanisms of action…, and universities may not have the resources or inclination to work out the practical implications of all such research, i. e. , finding and identifying compounds able to affect the mechanism discovered. that is no failure of the law' s interpretation, but its intention. patents are not awarded for academic theories, no matter how groundbreaking or necessary to the later patentable inventions of others. … that research hypotheses do not qualify for patent protection possibly results in some loss of incentive, although ariad presents no evidence of any discernable impact on the pace of innovation or the number of patents obtained by universities. but claims to research plans also impose costs on downstream research, discouraging later invention .
universities argue that if they are forced to disclose the terms of prior licensing agreements, it will undermine their negotiating position with a new potential licensee. if, however, public companies must disclose the contents of their license agreements in order to protect the interests of those funding them (i. e. , shareholders) as a matter of public policy, then it is not clear why a university should not be required to disclose the contents of its license agreements in order to protect those who fund it (i. e. , the public). the question of human resources needed to ensure transparency is very real and needs to be taken into account, but the principle of public disclosure should be entrenched within public institutions, particularly when the licensed inventions arise from publicly funded research, and especially when data are being collected and reported already. government and nonprofit research dollars should come with public accountability .
taken as a group, these decisions suggest that some of the potential obstacles to innovation that patents cause in diagnostics may not be as high, nor the amount of intellectual territory enclosed and enforced as expansive as some had feared. a clear research exemption, simplified method for challenging patents (e. g. opposition proceedings or inter partes re - examination requests) and improved examination procedures to avoid overly broad patent claims could help quell concerns over blocked research and overly broad patents. 55 overall, the problem does not lie wholly in patent law but in how decisions are made about what is patented (methods v. products) and how patents are managed and used. with one or a few successful challenges to broad patents enforced for diagnostic purposes, the business models of enforcing monopolies on genetic testing for specific conditions would likely give way to more cross - licensing, more competition, and faster innovation in testing methods .
the draft report also made the case for a mandatory scheme among manufacturers, obliging them to share technical information and parts with independent repairers .
last week the accc accepted a court enforceable undertaking from holden, in relation to findings that it misrepresented consumers' rights under consumer law .
as noted above, some ttos are expected to be self - sustaining and suffer from a serious lack of resources. this situation has several consequences. first, the agreements that ttos pursue will not necessarily aim to promote dissemination but focus first on securing revenues for the office itself. second, ttos lack resources to train managers on how to implement guidelines and to understand better the particular challenges that different technologies raise. the dna diagnostic market is complex and rapidly evolving. for example, technology licensing officers need to know that the development of genetic testing after the discovery of the gene requires far less investment than the development of therapeutics, thus suggesting that exclusive licenses may not be as necessary. 11 without a more nuanced and informed understanding of how optimal patenting, dissemination, and licensing decisions vary across different types of technologies and uses, ttos cannot fulfill their mandate: transferring technology .
walsh jp, ashish a, cohen w. patents in the knowledge - based economy. in: cohen w, merrill s, editors .
sekhsaria writes about all these issues clearly and cogently, his information bolstered by tables and charts. the only thing i missed was a comprehensive map of the islands. but if you are planning a trip to this magical paradise, i would suggest you throw away your glossy brochures and read this book instead. you’ll end up a wiser, kinder, more empathetic and sensible visitor—the only kind the islands can perhaps afford to welcome .
a week earlier, the united states court of appeals for the federal circuit held in ariad pharmaceuticals, inc. et al v. eli lilly and company 3 that a researcher must do more than identify that a class of compounds has a certain effect: he or she must actually describe what those compounds are. this effectively eliminated the award of patents over basic research, requiring, instead, that the inventor “actually perform the difficult work of ‘invention’—that is, conceive of the complete and final invention with all its claimed limitations—and disclose the fruits of that effort to the public. ”
the most recent flare - up is the decision of the united states district court for the southern district of new york in association for molecular pathology et al. v. united states patent and trademark office et al. 2 on march 29, 2010, us federal district court judge robert sweet ruled that isolated dna is not patentable in the united states, and also that method claims relevant to testing for brca1 and brca2 genes are invalid. essentially, the district court held that neither isolated dna nor cdna are sufficiently different from dna as it occurs within their host cells to be considered an invention. as for the diagnostic tests, the court held that they simply involved drawing a mental correlation between facts, something that does not fall within the scope of what is patentable .
mixing narrative and documentary filming in a unique way the story is autobiographical and is about a date rape dissecting the characters and circumstances around it. by following the effects of the incident on the main character we grow to understand the tremendous impact of what many people don' t consider to be rape .
set in 2010, the third installment of fargo centers on emmit and his slightly younger brother ray stussy (ewan mcgregor). emmit, the parking lot king of minnesota, sees himself as an american success story, whereas ray is more of a cautionary tale. forever living in his more successful brother’s shadow, ray is a balding and pot - bellied parole officer with a huge chip on his shoulder about the hand he’s been dealt – and he blames his brother. their sibling rivalry follows a twisted path that begins with petty theft but soon leads to murder, mobsters and cut - throat competitive bridge .
fans should expect this fargo to continue what the previous seasons have started. hawley has taken his time with the new episodes — season 2 finished airing in december 2015 — and everything we’ve seen from the previews and teasers indicates that the series will continue to operate along the same lines as the first two seasons. the cast is a good indication, too - - carrie coon and michael stuhlbarg, in particular, tend to make projects they’re in better and not worse .
ewan mcgregor as ray stussy looks about as down on his luck as a man can get. the less successful brother of the “parking lot king” of minnesota just reeks of desperation, making him right at home in the world of fx’s fargo. in less than a month’s time, we’ll likely see ray make some very bad and very foolish decisions that get a lot of people hurt. i can’t wait. for now, let’s watch some new fargo season 3 teasers .
powell a, chandrasekharan s, cook - deegan r. spinocerebellar ataxia: patient and health professional perspectives on whether and how patents affect access to clinical genetic testing .
the first response to concerns is often a call to change patent law. 39, 47 - 48 however, as recent research indicates, the central problem does not lie with patents over human genes themselves so long as the law incorporates the appropriate checks and balances. the recent suit challenging myriad' s patents on brca genes notwithstanding, 2 the following discussion indicates that there is little evidence on which to conclude that limiting the ability to patent genes is the only way to solve the problems in the system .
‘setting the context’ does exactly that, giving us a background picture of what had been happening on the islands, followed by the legal cases involving various issues (like logging and the treatment of tribals). ‘indigenous people’ deals with tribals—the jarawa and onge who have inhabited the islands for 40, 000 years and now seem to be in terminal decline, and ‘environment, ecology and development’ deals with the unique often endemic flora and fauna found on the islands. the final section, ‘december 2004’ talks of the disastrous impact of the earthquake and tsunami of that year—an event that put the spotlight on this troubled paradise .
while under provisions 64 of the bayh - dole act, all recipients of federal grants must report on activities involving the disposition of certain intellectual property rights that result from federally funded research, the information is incomplete and cannot be obtained because of strictures on access to the data. a clause of the act was intended to protect proprietary data from public access through the freedom of information act 35 u. s. c. § 202 (c) (5). the way the implementing regulations were written, however, went well beyond this, and gave licensees veto power over nongovernment disclosure of information. 65 ttos file reports with the interagency edison (iedison) database when they license inventions from most government funders. the reporting requirements do not require the disclosure of the licensing terms, and what is reported to edison is not publicly available. indeed, access to iedison is highly restricted and unavailable for study or use outside government, and even government officials wanting to study technology transfer have been denied access unless they get permission from all licensees, a nearly impossible hurdle to overcome .
colaianni a, chandrasekharan s, cook - deegan r. impact of gene patents and licensing practices on access to genetic testing and carrier screening for tay - sachs and canavan disease .
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that figure is just stunning ,
mr sims said ,
and we think it' s got a lot to do with manufacturers probably misleading people to use dealers for repairs .
recognition must also be given to the fact that ttos do not negotiate licenses in a vacuum: they negotiate largely with industry partners. if industry is unwilling to accept nonexclusive licenses, broad research exemptions or other terms that ttos propose to support research, ttos have little room to maneuver. currently, there is no incentive–whether external or through the threatened use of government march - in rights under the bayh - dole act - - to curb industry behavior even when it is problematic. ttos with limited funding, limited staffs and unreasonable expectations to be sustainable, cannot be expected to resist intransigence by licensees .
of course, one of the main reasons why we are so interested in the islands is because of the wealth they hold in the form of their beautiful evergreen rainforests. wholesale logging and plantation in the past has played havoc with the islands’ ecology—until it was stopped by the courts. but like everywhere else in the country, it’s the same old story of laws not being implemented and court decisions being ignored .
method claims in patents related to diagnostic testing, however, bear special mention. while many pharmaceutical patents claim products as chemical entities, universities and biotechnology firms also tend to patent ways of using knowledge, including method patents that affect genetic tests. in fact, huys et al. conclude that thirty percent of method claims relating to genetic testing are difficult if not impossible to circumvent. such claims tend to be broad, often to the point of vagueness, and many cover all conceivable ways to conduct genetic tests on a gene or for a clinical condition. in the 15 of 22 conditions that huys et al. found had at least one “blocking” claim, most such claims were to methods. in the diagnostic realm, blocking patents thus appear to be common, present in 68 percent of the clinical conditions studied .
many concerns originate in the following context: currently, universities frequently seek patents over early stage inventions 9 and license patents exclusively half the time. 10 - 13 a study by mowery et al. notes the following: “a relatively high fraction of all inventions that are licensed - - as high as 90% for uc licenses and no less than 58. 8% for stanford licenses of “all technologies” during this period - - is licensed on a relatively exclusive basis, and these shares are similar for biomedical inventions. ” 10 many of those licenses will endure for many years, including licenses on university patents relevant to dna diagnostics .
implementation of licensing guidelines and best practices is difficult when interests and goals are not aligned. participants at a workshop held at duke university in april 2009 addressed the role of universities in dna patents and diagnostic testing and noted that those at the front line of implementing these guidelines, technology transfer offices (ttos), face many hurdles to implementation. many university administrators view patents as a means to secure revenues (to subsequently reinvest in research) and believe that exclusive licenses generate the most revenues. while the evidence 59 is quite clear that most ttos either break even or lose money on technology transfer and that many of the most lucrative university patents have entailed nonexclusive licensing, this view persists. compounding this problem, universities expect ttos to generate sufficient revenues to be sustainable. despite usually being unrealistic, such expectations can lead ttos towards licensing strategies that promote short - term income over dissemination and broad availability .
another major threat comes from immigration (from the mainland) and unbridled tourism which force the islands to support a population far beyond their carrying capacity. (port blair suffers from an acute water shortage ever so often. )
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making licensing terms of publicly funded inventions more transparent would require a re - write of the implementing regulations to change interpretation of the confidentiality clause of the bayh - dole act. the confidentiality provision in the bayh - dole act was intended to protect agencies from being forced to disclose proprietary data but its implementing regulation is so broad that it, in effect, restricts government action to use data without permission of the relevant licensee. current nondisclosure practices lead to data being unavailable for research aimed at improving knowledge about patenting and licensing practices. many studies could be undertaken on aggregated reported data, and there are many precedents for using census data, health statistics and other very private information in government databases. the original rationale for the bayh - dole act was that government - owned inventions were languishing for want of effective patent incentive to grantees and contractors; the current problem is that data on licensing practice are languishing in a government database that is not mined for valuable insights into patenting and licensing practices .
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sacghs may have judged that ttos are failing to respect existing norms and in the absence of any credible compliance measures, the simplest legal solution is to address the problem through exemption from infringement liability. if autm and bio want to preserve the option of exclusive licensing when needed to get genetic tests to market, then compliance with guidelines needs to be credible. criticizing deviations when they come to light, with the long - term goal of increasing compliance with stated norms would go a long way to reducing the need for a diagnostic use exemption. moreover, enforcing nonexclusive licensing norms can preserve revenue streams, using the cystic fibrosis and huntington' s models, whereas a diagnostic use exemption would eliminate those revenues because the patents would be unenforceable for diagnostic uses .
while the biotechnology industry tried to portray myriad as an outlier, a series of detailed case studies 15, 18 - 24 conducted by duke university' s center for genome ethics law and policy reveal that in fact, myriad' s business model is not unique. as these studies illustrate, diagnostic companies such as athena diagnostics and pgxhealth, have adopted similar or even more aggressive business models, and shut out university laboratories from offering genetic testing for diseases such as long qt syndrome and alzheimer' s disease. in the case of alzheimer' s disease, genes and method patents for diagnostic testing were initially patented by duke university (and other academic institutions) and licensed exclusively to athena diagnostics. athena diagnostics then used its patents aggressively to prevent others from carrying out the test .
islands by their very nature are hothouses of endemism as species evolve quicker on them in order to fit snugly into special niches found there— and the andaman and nicobar islands are no exception. thus, they need a greater degree of protection—and more research to enable that .
many of the longstanding mom - and - pop specialty shops that filled neighborhoods and supplied artists with obscure and exotic items have been bought up or driven out of business by stores that are more art - supply supermarkets, a survey of the sector by the post has discovered .
on april 30, another venerable name will disappear. on that date, a. i. friedman, an 80 - year - old art supply store on west 18th street, will go dark — the fourth such independent retailer to bite the dust over the past two years .
in an attempt to better understand why these concerns persist and what role universities play as patentees and often exclusive licensors, this article outlines university technology transfer practices and business models that have given rise to the concerns. we review how the concerns have been addressed to date and the obstacles to doing so in the future. the obstacles include 1) recognizing that diagnostics is a highly unusual market, and that the problem is not so much legal in nature or necessarily about what gets patented, so much as how patents are licensed and enforced; and 2) changing university patent management strategies and practices. changing licensing practices, in turn, depends on 1) a sharper definition of what constitutes research that needs to be protected in licensing provisions, 2) more coherent university policies to promote broad dissemination along with incentives for industry compliance with best practices, 3) greater recognition of problems and proposing of constructive solutions by key players, 4) transparent reporting of gene patents and diagnostic testing license agreements and 5) secure funding for technology transfer offices. while legislative change may ultimately be necessary to facilitate these changes in practice, many problems can be addressed without statutory change .
the chilly tv spots for the upcoming season of fargo have featured clues of the trouble awaiting creator and showrunner noah hawley ‘s (legion) new batch of characters, played by the likes of carrie coon (the leftovers), michael stuhlbarg (boardwalk empire), mary elizabeth winstead (10 cloverfield lane), and an actor who leaves a strong impression in one of the new promos, david thewlis (anomalisa). thewlis plays a mysterious loner looking to get into the parking lot business with emmit stussy, who found more luck and success in life – or maybe just worked harder – than his disgruntled brother .
then again, a previously great series suddenly going off the rails mid - run isn’t unprecedented, and there’s always the chance that hawley, who also ran the first season of legion, is spread too thin. but until we see otherwise, there’s little reason to expect anything but greatness from the third season of fargo .
one month earlier, on february 10, 2010, the secretary' s advisory committee on genetics, health and society (sacghs), 4 after a careful study of current knowledge on the effects of patenting genes on research and accessibility to genetic tests, found that there is no convincing evidence that patents either facilitate or accelerate the development and accessibility of such tests. on the other hand, the committee found that there was some, albeit limited, evidence that patents had a negative effect on clinical research and on the accessibility of genetic tests by patients. further, most gene patents relevant to diagnostics were held by universities on the basis of research funded by the public money. given this, the committee recommended that universities be more cautious in patenting and licensing human genes, that there be more transparency and accountability for university licensing practices and that an existing exception protecting medical practitioners from patent infringement when they undertake surgery or treat a patient' s body be extended to include the provision of genetic diagnostic testing .
while myriad genetics' patents over genes related to hereditary breast and ovarian cancer – the subject of the decision in association for molecular pathology et al. v. the united states patent and trademark office et al. – were among the first to generate intense public controversy, others followed. athena diagnostics' exclusive licenses to patents covering genes and methods of testing for alzheimer' s disease and other neurological and metabolic conditions, as well as other entities' screening for canavan disease, hemochromatosis and other single - gene conditions has also generated fierce debate. in the case of canavan testing litigation resulted from licensing restrictions that inhibited freedom of action among those seeking to get genetic tests. these concerns have existed for over a decade without resolution. 5 - 6 the maturity of microarray technology that allows for multi - allele genotyping and now the prospect of full - genome sequencing deepen these concerns. 7 a legacy of exclusively licensed gene patents casts a shadow of patent infringement liability over the future of multi - allele testing and full - genome analysis .
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the 2000s saw a plethora of policy reports about dna patents, such as those from the nuffield council on bioethics, 27 the national academy of sciences, 28 the ontario ministry of health 29 and the australian law reform commission. 30 academic articles examined the concerns, the extent to which concerns were founded and the role of industry, universities and legislative reform in addressing these concerns. 5 - 6, 26, 31 - 39 some countries also made statutory changes to their patent and / or health laws. france expanded compulsory licensing laws, 40 and belgium did the same and also carved out a diagnostic use exemption from patent infringement liability. 41 the united states patent and trademark office developed guidelines on “utility” and “written description” specifically for examining gene patent applications. 42
yet another threat emerges from the interest the navy and defence organisations are showing in the islands, for instance by using uninhabited ones for missile target practice and the proposal to set up a nuclear power plant on them. the tsunami of 2004 devastated and actually physically tilted the islands— one disaster we can’t thankfully blame on ourselves. but as usual, recovery and rehabilitation have been woeful .
in order to promote change, university - industry relationships need to be more transparent. the current lack of transparency over existing university - industry relationships is a major hurdle to system improvement. 11 for example, license agreements between universities and start - up and private companies are generally unavailable, even in general terms. the only exceptions are universities or companies that voluntarily make such information public .
changes to remedy problems with the system include the following: (1) a clear definition of research that should be exempt from patent infringement liability, (2) university leadership in promoting the alignment of technology transfer licensing practices with the broader university goal of dissemination coupled with (3) incentives to promote industry compliance and leadership on behalf of autm and bio in recognizing problems and proposing constructive solutions. we also need (4) adequate funding to technology transfer offices to learn about and implement changing practices and (5) greater transparency in reporting patent holdings and licensing agreement terms .
despite sophia burset' s best efforts, the ladies of the litchfield correctional facility lack style. there are only so many ways to jazz up khaki scrubs, you know? in real life, however, the cast of orange is the new black is anything but dowdy. we' ve gathered pictures of taylor schilling, laura prepon, taryn manning, ruby rose, and the rest of the cast in and out of their jumpsuits, and you might be shocked at the difference with some of the women — especially blanca! take a look at all the pictures ahead if you' re in the mood for your jaw to drop .
sign the petition at urltoken robert bateman takes a stand against the threat of oil spills on bc' s coast. the bc and canadian governments are supportive of bringing oil tankers to british columbia' s north coast. if this were to happen, spills would be inevitable, and the consequences on this wild and intact stretch of coast would be profound. sign the petition at: urltoken and use the share menu to pass this video on! produced by: dogwood initiative concept: rethink communications director and editor: bill weaver, across borders media cinematography: david malysheff, gamut productions / bill weaver music: niels petersen, lebeau - petersen productions and, many thanks to robert bateman... .
a recent study 49 from belgium - the huys et al. study - suggests that relatively few claims in gene patents block competing laboratories from providing genetic tests. this study of 145 active patent documents (267 independent claims) related to genetic diagnostic testing of 22 inherited diseases (including method claims, gene claims, oligo claims and kit claims) that the european patent office and the united states patent and trademark office issued. it concluded that clinicians could easily get around thirty - six percent of claims and could, with work, circumvent another forty - nine percent of claims. only fifteen percent of claims would be difficult or impossible to circumvent. out of the gene claims studies, only 3% were concluded to be blocking. however, as discussed below, blocking claims were more prevalent with respect to method claims.
not a pretty picture is an american docudrama film released in 1976 . the film was written , produced and directed by martha coolidge , marking her narrative feature film directorial debut , after years of working as a documentary filmmaker in the early to mid-1970s . the film is a retelling about coolidge , who was date raped when she was sixteen years old . the film follows the aftermath of the incident on the main character . 
not a pretty picture is an american docudrama film released in 1976. the film was written, produced and directed by martha coolidge, marking her narrative feature film directorial debut, after years of working as a documentary filmmaker in the early to mid-1970s. the film is a retelling about coolidge, who was date raped when she was sixteen years old. the film follows the aftermath of the incident on the main character.
not a pretty picture is an american docudrama film released in 1976. the film was written, produced and directed by martha coolidge, marking her narrative feature film directorial debut, after years of working as a documentary filmmaker in the early to mid-1970s. the film is a retelling about coolidge, who was date raped when she was sixteen years old. the film follows the aftermath of the incident on the main character.