fate as a rat
1, 2 - dichloropropane: metabolism and fate in the rat. - pubmed - ncbi
t. osimensis stem cells, originally derived from female rat cells, were found in both male and female rat - mouse chimeras .
) —endangered rodents native to a japanese island—carry just a single x chromosome. in a study published today (may 12) in
of the university of miyazaki in japan used fibroblasts from the tail of a female spiny rat to derive induced pluripotent stem cells (ipscs). these cells were capable of differentiating into both female and male germ cells in the body of a host organism, a mouse - spiny rat chimera .
sudbata kato pluh or
fate as a rat
is a schizophrenic excuse for a work of art. while one of the most talented bulgarian actors (ivailo hristov) tries to do something in this picture, the rest of the cast is totally lost. our tradition of creating complex, symbollic movies has once again proven to be inefficient .
fate as a rat
is the most idiotic picture of the year in bulgaria. it once again stands to show that cinema in our country is experiencing its most dramatic downfall. somebody has to do something, but who? definately not the people who produced this mess. p. s. : there is no point in trying to give the movie' s plot - there is no such. the picture is a confused hodge - podge of trifle ideas about our existence and our pains. enough said .
induced pluripotent stem cells from the tail of a female spiny rat can differentiate into male or female germ cells, outlining a possible escape route from extinction for this endangered species .
oscar winners morgan freeman and john legend added as presenters along with j. j. abrams, sacha baron cohen and henry cavill dave grohl will give a special performance
the research team cultured fibroblasts from the tail of a female spiny rat, which was released back into the wild. after trying a variety of induction and culture conditions, the authors obtained
1. the metabolism of 1, 2 - dichloropropane in the rat has been investigated. the major urinary metabolite has been isolated and identified as n - acetyl - s - (2 - hydroxypropyl) cysteine. two minor metabolites of 1, 2 - dichloropropane have been identified as beta - chlorolactate and n - acetyl - s - (2, 3 - dihydroxypropyl) cysteine. 2. the fate of 1 - chloro - 2 - hydroxypropane, a proposed intermediate metabolite of 1, 2 - dichloropropane, has been investigated. apart from its known urinary metabolite, n - acetyl - s - (2 - hydroxypropyl) cysteine, two oxidative metabolites were detected. these were identified as beta - chlorolactaldehyde and beta - chlorolactate. 3. a pathway is proposed for the metabolism and fate of 1, 2 - dichloropropane in the rat. this accounts for previous observations made for the fate of radioactivity from administration of 1, 2 - dichloro [ 1 - 14c ] propane. 4. the microbial and mammalian metabolism of several halogen - containing foreign compounds is discussed .
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the researchers traced the injected ipscs with a fluorescent marker, and determined that about a quarter of embryos and pups were chimeras. when they examined the adult chimeras, the authors found ipscs in multiple tissues, including patches of brown spiny rat skin and fur. ipscs also contributed to spermatids and an oocyte, but the number of these germ cells derived from spiny rat ipscs was low .
“we have successfully generated true naïve ipscs from t. osimensis and interspecific chimeras with [ spiny rat ] cells throughout their bodies, ” honda wrote in an email to the scientist. “female t. osimensis ipscs could contribute and survive as male germ cells in adult interspecific testes, ” he added .
it is a story about a group of friends who live in a small seaport town. their lifestyle is rigorous, their joys are simple and their sex life is raw. their concepts of man' s dignity, ... see full summary »
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@ siennechambers: unless you meant the vocal sample... its from a poetry reading
the fate of the three isomeric benzoic acid - substituted monochlorobenzanilides has been studied in the rat after their oral administration. the excretory profile of all three isomers was similar with over half of the dose being excreted in the 0 - 24 hour urine and between 83 - 87% being recovered during the three days following administration. the most prominent route of metabolism was that of 4' - hydroxylation on the unsubstituted aniline moiety followed by glucuronic acid conjugation .
it is a story about a group of friends who live in a small seaport town. their lifestyle is rigorous, their joys are simple and their sex life is raw. their concepts of man' s dignity, friendship and duty are wrong and primitive. the film helps us to understand and forgive them .
“this is a very intriguing paper, ” said oliver ryder, who is the director of conservation genetics at the san diego zoo institute for conservation research and did not participate in the work. generating “chimeras that can incorporate induced pluripotent stem cells from an endangered species and show indications of producing gametes from the donor cells” has exciting potential as another method of species conservation, he explained .
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lacma and the academy co - present a major u. s. exhibition highlighting the prolific career of mexican cinematographer gabriel figueroa
the academy continues residency at the metrograph theater in new york with “the ballad of gregorio cortez” and tribute to george a. romero
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honda confirmed that his team plans to work on improving the efficiency of germ cell production. he also wants to move the system out of chimeras and into the petri dish, in order to achieve generation of amami spiny rat eggs, sperm, and eventually embryos .
a. honda et al. , “flexible adaptation of male germ cells from female ipscs of endangered tokudaia osimensis, ” science advances, 3: e1602179, 2017 .
a next step is to determine whether “the germ cells that were developed were functional, ” said monika ward, who studies y chromosome genes at the john a. burns school of medicine at the university of hawaii and did not participate in the study. “because of the low efficiency the authors were not really able to test if [ the cells ] can function in fertilization, ” she explained .
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“it isn’t clear to me that using induced pluripotent stem cells from females in chimera mice, which are then going to have the environmental component of the mouse, is really going to help disentangle how sex is determined in the spiny rat, ” melissa wilson sayres, who investigates sex chromosome evolution at the arizona state university in tempe and was not involved in the work, told the scientist. but “the more we can study sex determination and really understand in what ways is it flexible [ and ] inflexible, the more we illuminate how flexible our own sex determination system may be. ”
the potential uses of such a system could extend beyond spiny rats, too. “we work on preserving species in their habitats. we work on captive breeding. we work on assisted reproduction, ” ryder said, “but there are species that are threatened with extinction that might not be able to be saved without the application of more advanced genetic and reproductive technologies. ”
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official submission of bulgaria for the' best foreign language film' category of the 74th academy awards in 2002 .
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drug metabol drug interact. 1991; 9 (1): 31 - 9 .
department of pharmacology and toxicology, st. mary' s hospital medical school, london, england .
thefatrat gaming mix 2016 [ best songs: monody, unity, xenogenesis, time lapse, windfall... ]
in most mammals, females have two x chromosomes and males have one x and one y. but both male and female amami spiny rats (
ipsc lines. they introduced these cells into mouse blastocysts, and then implanted them into surrogate mouse mothers .
and though this study makes clear that sex determination is flexible in spiny rats, one question that remains unanswered is how male and female sex characteristics actually arise in the rodents, honda said .
@ wwwrossharrison: oh wow ok, thats awesome. it sounds just like ben mendelsohn
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fate as a rat ( bulgarian : съдбата като плъх ) is a 2001 bulgarian film directed by ivan pavlov . it was bulgaria 's submission to the 74th academy awards for the academy award for best foreign language film , but eventually was not nominated . 
fate as a rat (bulgarian: съдбата като плъх) is a 2001 bulgarian film directed by ivan pavlov. it was bulgaria's submission to the 74th academy awards for the academy award for best foreign language film, but eventually was not nominated.
fate as a rat (bulgarian: съдбата като плъх) is a 2001 bulgarian film directed by ivan pavlov. it was bulgaria's submission to the 74th academy awards for the academy award for best foreign language film, but eventually was not nominated.