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<!-- Field: Rule-Page --><DIV STYLE="margin-top: 12pt; margin-bottom: 3pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">As filed with the Securities and Exchange
Commission on April 28, 2020</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Registration No.&nbsp;<U STYLE="text-decoration: none">333-________</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM S-1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT UNDER THE SECURITIES
ACT OF 1933</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 14pt"><B><U>Q BIOMED
INC.</U></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;(Name of Issuer in Its Charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 33%">&nbsp;</TD>
    <TD STYLE="width: 34%; text-align: center"><FONT STYLE="font-size: 10pt"><B><U>Nevada</U></B></FONT></TD>
    <TD STYLE="width: 33%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(State or other jurisdiction</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">of incorporation)</P></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B><U>2834</U></B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B><U>46-4013793</U></B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(Primary Standard Industrial Classification Code Number)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(IRS Employer Identification No.)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>c/o Ortoli Rosenstadt LLP</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>366 Madison Avenue &ndash; 3rd Floor</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>New York, NY 10017</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Telephone: 212-588-0022</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Fax: 212-826-9307</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address including zip code, and telephone
number, including area code, of registrant&rsquo;s principal executive offices)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Vcorp Services, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">701 S. Carson Street, Suite 200</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Carson City NV 89701</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>(888) 528 2677</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address, including zip code, and
telephone number, including area code, of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Copies to:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;<B>William Rosenstadt, Esq.</B><BR>
<B>Tim Dockery, Esq.</B><BR>
<B>Ortoli Rosenstadt LLP</B><BR>
<B>366 Madison Avenue, 3rd&nbsp;Floor</B><BR>
<B>New York, New York, U.S.A., 10017</B><BR>
<B>Telephone: (302) 738-6680</B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>As soon as practicable after this
registration statement becomes effective.</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Approximate date of commencement of proposed
sale to the public</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If any of the securities being registered
on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the
following box:&nbsp;<FONT STYLE="font-family: Wingdings">x</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If this Form is filed to register additional
securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities
Act registration statement number of the earlier effective registration statement for the same offering.&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If this Form is a post-effective amendment
filed pursuant to Rule 462(c) under the Securities Act of 1933, check the following box and list the Securities Act registration
statement number of the earlier effective registration statement for the same offering.&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If this Form is a post-effective amendment
filed pursuant to Rule 462(d) under the Securities Act of 1933, check the following box and list the Securities Act registration
statement number of the earlier effective registration statement for the same offering.&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2
of the Exchange Act. (Check one):</P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%"><FONT STYLE="font-size: 10pt">Large accelerated filer&#9;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD>
    <TD STYLE="width: 50%"><FONT STYLE="font-size: 10pt">Accelerated filer&#9;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Non-accelerated filer&#9;<FONT STYLE="font-family: Wingdings">x</FONT></FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Smaller reporting company&#9;<FONT STYLE="font-family: Wingdings">x</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Emerging growth company&#9;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold">Title of Each Class of Securities to Be Registered</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amount to Be</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Registered (1)</B></P></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Proposed</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Maximum</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Offering</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Price</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Per</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Security (2)</B></P></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Proposed</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Maximum</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Aggregate</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Offering</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Price (2)</B></P></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amount of</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Registration</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Fee</B></P></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 44%; font-size: 10pt; text-align: left">Shares of Common Stock Issuable upon Conversion of Series A Convertible Preferred Stock or Payments of Dividends Theron (3)</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">1,836,286</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">2.03</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">3,727,661</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">484</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Shares of Common Stock Issuable upon Conversion of Series B Convertible Preferred Stock or Payments of Dividends Theron (4)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3,163,714</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">2.03</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">6,442,339</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">836</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: right">Total:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5,000,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">2.03</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">10,150,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">1,320</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; text-align: center"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD STYLE="width: 91%; text-align: justify"><FONT STYLE="font-size: 10pt">Pursuant to Rule 416, there are also being registered such additional securities as may be issued to prevent dilution resulting from stock splits, stock dividends, or similar transactions as a result of the anti-dilution provisions contained in the Series A Convertible Preferred Stock and the Series B Convertible Preferred Stock.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Estimated solely for the purpose of calculating the registration fee for this offering pursuant to Rule 457(c) under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), using the closing price on April 24, 2020 (a date within five days of the initial filing of this registration statement) of $2.03 as reported on the OTCQB.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(3)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Represents 1,836,286 shares of the Registrant&rsquo;s common stock being registered for resale that may be acquired upon the conversion of shares of Series A Convertible Preferred Stock or payments of dividends thereon.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(4)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Represents 3,163,714 shares of the Registrant&rsquo;s common stock being registered for resale that may be acquired upon conversion of shares of Series B Convertible Preferred Stock or payments of dividends thereon.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>THE REGISTRANT HEREBY AMENDS THIS REGISTRATION
STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT
WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT
TO SAID SECTION 8(A), MAY DETERMINE.</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; color: red"><B><I></I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; color: red"><B><I>The information in this
prospectus is not complete and may be changed. These securities may not be resold until the registration statement filed with the
Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities, and it is not soliciting
offers to buy these securities in any jurisdiction where the offer or sale is not permitted.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; color: red"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right; color: red"><B><I>Subject to Completion&mdash;Dated
April 28, 2020</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>PROSPECTUS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="logo.jpg" ALT=""></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>1,836,286 Shares of Common Stock</B>&nbsp;<B>underlying
shares of Series A Convertible Preferred Stock</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>3,163,714 Shares of Common
Stock</B>&nbsp;<B>underlying shares of Series B Convertible Preferred Stock</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This prospectus relates to the offer and
sale, from time to time, of up to 5,000,000 shares of common stock of Q BioMed Inc. (the &ldquo;Company&rdquo;, &ldquo;we&rdquo;,
 &ldquo;us&rsquo; and &ldquo;our&rdquo;) by the stockholder named in the section of this prospectus entitled &ldquo;Selling Stockholder&rdquo;.
We entered into a Securities Purchase Agreement with the selling stockholder on April 6, 2020 by which the selling stockholder
acquired 176,566 shares of Series A Convertible Preferred Stock (the &ldquo;Series A Preferred Shares&rdquo;) convertible into
shares of our common stock, of which 1,836,286 shares of our common stock are being offered for resale pursuant to this prospectus
(together with shares of our common stock to be paid as dividends on the Series A Shares, the &ldquo;Series A Conversion Shares&rdquo;),
and 503,134 shares of Series B Convertible Preferred Stock (the &ldquo;Series B Preferred Shares&rdquo; and together with the Series
A Preferred Shares, the &ldquo;Preferred Shares&rdquo;) convertible into shares of our common stock, of which 3,163,714 shares
of our common stock are being offered for resale pursuant to this prospectus (together with shares of our common stock to be paid
as dividends on the Series A Shares, the &ldquo;Series B Conversion Shares&rdquo; and together with the Series A Conversion Shares,
the &ldquo;Conversion Shares&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We are not selling any shares of common
stock in this offering, and we will not receive any proceeds from the sale of the Conversion Shares by the selling stockholder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our common stock is quoted on the OTC Market
Group Inc.&rsquo;s Venture Market (the &ldquo;OTCQB&rdquo;) under the symbol &ldquo;QBIO&rdquo;. On April 17, 2020, the last reported
sale price of our common stock on the OTCQB was $2.07 per share, and on April 17, 2020 we had 22,468,185 shares of common stock
outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The selling stockholder may offer all or
part of the Series A Conversion Shares and Series B Conversion Shares for resale from time-to-time through public or private transactions,
at either prevailing market prices or at privately negotiated prices.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This prospectus provides a general description
of the securities being offered. You should read this prospectus and the registration statement of which it forms a part before
you invest in any securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Investing in our securities involves
risks. You should review carefully the risks and uncertainties described under the heading &ldquo;<U>Risk Factors</U>&rdquo; on
page 1.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Neither the Securities and Exchange
Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus
is truthful or complete. Any representation to the contrary is a criminal offense.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">The date of this prospectus is April __,
2020</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<DIV STYLE="padding: 10pt; border: Black 1pt solid">

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Table of Contents</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 5pt; vertical-align: top; border-bottom: black 1pt solid; text-align: right; padding-left: 5pt"><FONT STYLE="font-size: 10pt"><B>Page</B></FONT></TD>
    </TR>
<TR>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: justify; padding-left: 5pt"><A HREF="#A1"><FONT STYLE="font-size: 10pt">Prospectus Summary</FONT></A></TD>
    <TD COLSPAN="2" STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A1"><FONT STYLE="font-size: 10pt">ii</FONT></A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; width: 95%; text-align: justify; padding-left: 5pt"><A HREF="#A2"><FONT STYLE="font-size: 10pt">Risk Factors</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; width: 1%; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; width: 4%; text-align: right; padding-left: 5pt"><A HREF="#A2"><FONT STYLE="font-size: 10pt">1</FONT></A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: justify; padding-left: 5pt"><A HREF="#A3"><FONT STYLE="font-size: 10pt">Use of Proceeds</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A3">16</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: justify; padding-left: 5pt"><A HREF="#A4"><FONT STYLE="font-size: 10pt">Determination of Offering Price</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A4">17</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: justify; padding-left: 5pt"><A HREF="#A5"><FONT STYLE="font-size: 10pt">Plan of Distribution</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A5">17</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: justify; padding-left: 5pt"><A HREF="#A6"><FONT STYLE="font-size: 10pt">Description of Securities</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A6">19</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: justify; padding-left: 5pt"><A HREF="#A7"><FONT STYLE="font-size: 10pt">The Purchase Agreement</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A7">23</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: justify; padding-left: 5pt"><A HREF="#A8"><FONT STYLE="font-size: 10pt">Selling Stockholder</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A8">23</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: justify; padding-left: 5pt"><A HREF="#A9"><FONT STYLE="font-size: 10pt">Business</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A9">27</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#A10"><FONT STYLE="font-size: 10pt">Market For Registrant&rsquo;s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A10">36</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#A11"><FONT STYLE="font-size: 10pt">Management&rsquo;s Discussion and Analysis of&nbsp;Financial Condition&nbsp;and Results of Operations</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A11">38</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#A12"><FONT STYLE="font-size: 10pt">Management</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A12">48</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#A13"><FONT STYLE="font-size: 10pt">Transactions with Related Persons</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A13">50</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#A14"><FONT STYLE="font-size: 10pt">Executive Compensation</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A14">50</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#A15"><FONT STYLE="font-size: 10pt">Beneficial Ownership of Principal Stockholders, Officers and Directors</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A15">51</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#A16"><FONT STYLE="font-size: 10pt">Legal Matters</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A16">53</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#A17"><FONT STYLE="font-size: 10pt">Disclosure of Commission Position of Indemnification For Securities Act Liabilities</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A17">53</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#A18"><FONT STYLE="font-size: 10pt">Experts</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A18">53</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#A19"><FONT STYLE="font-size: 10pt">Where You Can Find Additional Information</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#A19">53</A></TD>
    </TR>
<TR STYLE="background-color: white">
    <TD STYLE="padding-right: 5pt; vertical-align: top; padding-left: 5pt"><A HREF="#fins"><FONT STYLE="font-size: 10pt">Index to Financial Statements</FONT></A></TD>
    <TD STYLE="padding-right: 5pt; vertical-align: bottom; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5pt; vertical-align: top; text-align: right; padding-left: 5pt"><A HREF="#fins"><FONT STYLE="font-size: 10pt">F-1</FONT></A></TD>
    </TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

</DIV>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<DIV STYLE="padding: 9pt; border: Black 1pt solid">

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="A1"></A><B>PROSPECTUS SUMMARY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>This summary highlights selected information
contained elsewhere in this prospectus.&nbsp;&nbsp;This summary does not contain all the information that you should consider before
investing in the common stock.&nbsp;Before making an investment decision, you should carefully read the entire prospectus. In particular,
attention should be directed to the sections entitled &ldquo;Risk Factors&rdquo;, &ldquo;Business&rdquo;, &ldquo;Management&rsquo;s
Discussion and Analysis of Financial Condition and Results of Operations&rdquo; and the financial statements and related notes
thereto contained herein.</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Business Overview</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We are a commercial stage biotechnology
acceleration and development company focused on acquiring and in-licensing pre-clinical, clinical-stage and approved life sciences
therapeutic products. Currently, we have a portfolio of five products, including two FDA approved commercially available radiopharmaceuticals
for metastatic cancer bone pain (Strontium-89 and Metastron<SUP>TM</SUP>) and three development stage products: QBM-001 for rare
pediatric non-verbal autism spectrum disorder, Uttroside-B for liver cancer, and MAN 01 for glaucoma. Our licensed MAN platform
has several potential therapeutics in development in various indications, including vascular and infectious diseases. The infectious
diseases we may ultimately treat include influenza, Coronavirus, Ebola and others. We aim to maximize risk-adjusted returns by
focusing on multiple assets throughout the discovery and development cycle. We expect to benefit from early positioning in illiquid
and/or less well known privately-held assets, thereby enabling us to capitalize on valuation growth as these assets move forward
in their development.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our mission is to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 3%; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(i)</FONT></TD>
    <TD STYLE="width: 92%; padding-top: 0.1pt; padding-right: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">license and acquire pre-commercial innovative life sciences assets in different stages of development and therapeutic areas from academia or small private companies;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(ii)</FONT></TD>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">license and acquire FDA approved drugs and medical devices with limited current and commercial activity; and</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(iii)</FONT></TD>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">accelerate and advance our assets to the next value inflection point by providing strategic capital, business development and financial advice and experienced sector specific advisors.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In calendar 2020, we started generating
revenue from our Metastron and Strontium-89 products for pain palliation in bone metastases. Further, we will begin planning our
therapeutic expansion post-marketing phase 4 trial for Strontium-89. We also intend to file investigational new drug applications,
or INDs late in 2020 or early 2021, with the FDA for each of our Uttroside-B and MAN 01 assets for the treatment of liver cancer
and glaucoma, respectively. We also intend to advance our QBM-001 asset to address a non-verbal learning disorder in autistic children.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Corporate Information</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our principal executive offices are located
at 366 Madison Avenue, 3<SUP>RD</SUP> Floor, New York, NY 10017, and our telephone number is (212) 588-0022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>The Offering</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This prospectus relates to the offer and
sale from time to time of up to 5,000,000 shares of our common stock by the selling stockholder, up to 1,836,286 of which may be
issued upon the conversion of the Series A Preferred Shares by the selling stockholder or payment to the selling stockholder of
dividends thereon and 3,163,714 of which may be issued upon the conversion of Series B Preferred Shares by the selling stockholder
or payment to the selling stockholder of dividends thereon. On April 6, 2020, we entered into the Purchase Agreement with the selling
stockholder pursuant to which the selling stockholder purchased 176,566 Series A Preferred Shares and 303,134 Series B Preferred
Shares from us at an aggregate of $4,000,000 in cash and approximately $2,797,000 in convertible promissory notes.</P>

</DIV>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

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<DIV STYLE="padding: 10pt; border: Black 1pt solid">

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As of April 17, 2020, there were 22,468,185
shares of our common stock outstanding (of which 19,437,624 shares were held by non-affiliates), 176,566 Series A Preferred Shares
outstanding (none of which were held by affiliates) and 503,134 Series B Preferred Shares outstanding (none of which were held
by affiliates). Under the terms of a registration rights agreement entered into with the selling stockholder at the same time as
the Purchase Agreement, we must register with the U.S. Securities and Exchange Commission 5,000,000 shares of common stock for
resale by the selling stockholder, which shares represent 22.3% of our outstanding shares as of April 17, 2020 and 25.7% of such
shares held by non-affiliates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Issuances of our common stock upon the
conversion of the Series A Preferred Shares or the Series B Preferred Shares will not affect the rights or privileges of our existing
stockholders, except that the economic and voting interests of each of our existing stockholders will be diluted as a result of
any such issuance. Although the number of shares of common stock that our existing stockholders own will not decrease, the shares
owned by our existing stockholders will represent a smaller percentage of our total outstanding shares after any such issuance
to the selling stockholder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 40%"><FONT STYLE="font-size: 10pt"><B>Common stock offered by selling stockholder:</B></FONT></TD>
    <TD STYLE="width: 60%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">5,000,000 shares consisting of 1,836,286
        Series A Conversion Shares and 3,163,714 Series B Conversion Shares.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt"><B>Common stock outstanding:</B></FONT></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">22,468,185 shares as of April 17, 2020.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt"><B>Common stock&nbsp;outstanding after the offering:</B></FONT></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">27,468,185 shares, assuming no additional
        shares are issued prior to completion of the offering and excluding any shares of common stock underlying any outstanding options,
        warrants or unconverted Preferred Shares.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt"><B>Use of Proceeds:</B></FONT></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We will not receive any proceeds from the
        sale of Conversion Shares by the selling stockholder.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We received net proceeds (excluding our
        expenses) of approximately $6,797,000 from the sale of Preferred Shares under the Purchase Agreement, of which $4,000,000 was in
        cash and $2,797,000 was in exchange for our outstanding convertible debentures. We intend to use the cash proceeds from the sale
        of the Preferred Shares for general working capital purposes. We will retain broad discretion over the use of these proceeds.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We will not receive any proceeds upon conversion
        of the Preferred Shares or the sale of the Conversion Shares.&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt"><B>Quotation of common stock:</B></FONT></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our common stock is listed for quotation
        on the OTCQB market under the symbol &ldquo;QBIO.&rdquo;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt"><B>Dividend policy:</B></FONT></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We do not currently anticipate paying cash
        dividends on our common stock. Instead, we currently intend to retain any future earnings, if any, that we would have used to pay
        such dividends to fund the development and growth of our business.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our Preferred Shares carry an annual dividend
        equal to 8% of their liquidation value, which is equal, subject to customary adjustments, to their purchase price of $10 per Preferred
        Share plus any accrued but unpaid dividends thereon. As we have sold 679,700 Preferred Shares to date for gross proceeds (and with
        a liquidation value) of $6,797,000, we will have to pay $543,760 in dividends if all of such shares remain outstanding one year
        after issuance. Such dividends are to be paid in an amount of common stock equal to the dollar value of such dividend amount divided
        by the volume weighted average price (&ldquo;VWAP&rdquo;) of our common stock on the date of such dividend payment.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt"><B>Risk factors:</B></FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">An investment in our company is highly speculative and involves a significant degree of risk. See &ldquo;Risk Factors&rdquo; and other information included in this prospectus for a discussion of factors you should carefully consider before deciding to invest in shares of our common stock.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

</DIV>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 2.5in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<DIV STYLE="padding: 9pt; border: Black 1pt solid">

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SPECIAL NOTE REGARDING FORWARD-LOOKING
STATEMENTS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have made statements under the captions
 &ldquo;Risk Factors&rdquo;, &ldquo;Use of Proceeds&rdquo;, &ldquo;Management&rsquo;s Discussion and Analysis of Financial Condition
and Results of Operation&rdquo;, &ldquo;Business&rdquo; and elsewhere in this prospectus that are forward-looking statements. You
can identify these statements by forward-looking words such as &ldquo;may&rdquo;, &ldquo;will&rdquo;, &ldquo;expect&rdquo;, &ldquo;anticipate&rdquo;,
 &ldquo;believe&rdquo;, &ldquo;estimate&rdquo; and similar terminology. Forward-looking statements address, among other things:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&middot;</TD><TD STYLE="text-align: justify">implementing and developing our clinical programs and other aspects of our business plans;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&middot;</TD><TD STYLE="text-align: justify">financing goals and plans; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&middot;</TD><TD STYLE="text-align: justify">our expectations of when regulatory approvals will be received or other actions will be taken by
parties other than us.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We believe it is important to communicate
our expectations to our investors. However, there may be events in the future that we are not able to accurately predict or which
we do not fully control that will cause actual results to differ materially from those expressed or implied by our forward-looking
statements. These include the factors listed under &rdquo;Risk Factors&rdquo; and elsewhere in this prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Although we believe that our expectations
reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance,
or achievements. Our forward-looking statements are made as of the date of this prospectus, and we assume no duty to update them
or to explain why actual results may differ.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

</DIV>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="A2"></A>RISK FACTORS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Investing in our securities involves a
high degree of risk. You should carefully consider and evaluate all of the information included and incorporated by reference or
deemed to be incorporated by reference in this prospectus. Our business, results of operations or financial condition could be
adversely affected by any of these risks or by additional risks and uncertainties not currently known to us or that we currently
consider immaterial.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Risks Related to our Company</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>If we do not obtain additional financing,
our business may be at risk or execution of our business plan may be delayed.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As of the date hereof, we have raised our
operating funds&nbsp;through&nbsp;contacts, high net-worth individuals and strategic investors situated in the United States and
the Cayman Islands. We have only generated minimal revenue from operations since inception, all of which in our most recent quarter.
We have limited assets upon which to commence our business operations and to rely otherwise.&nbsp;&nbsp;At February 29, 2020, we
had cash and cash equivalents of approximately $0.7 million.&nbsp;&nbsp;In April 2020, we netted approximately $4 million from
the sale of the Preferred Shares. Even with these additional funds and any revenues that we generate, we may have to raise additional
funds within twelve months to continue operations. Additional funding will be needed to implement our business plan that includes
various expenses such as fulfilling our obligations under licensing agreements, legal, operational set-up, general and administrative,
marketing, employee salaries and other related start-up expenses. Obtaining additional funding will be subject to various factors,
including general market conditions, investor acceptance of our business plan and initial results from our business operations.
These factors may impact the timing, amount, terms or conditions of additional financing available to us. If we are unable to raise
sufficient funds, we will be forced to scale back or cease our operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>An overall decline in the health
of the economy and other factors impacting consumer spending, such as pandemics, natural disasters and fluctuations in inflation
and foreign currency exchange rates, may affect our ability to raise capital and to produce our sole product.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">We will require
additional funding to operate as planned, and the availability of such funding is sensitive to a number of factors, such as general
current and future economic and political conditions, recession and fears of recession, unemployment, interest rates, tax rates
and policies, inflation, war and fears of war, inclement weather, natural disasters, terrorism, outbreak of viruses, widespread
illness, infectious diseases, contagions and the occurrence of unforeseen epidemics and pandemics. The current coronavirus (Covid-19)
pandemic is testing the health of capital markets, and if that health deteriorates because Covid-19 or other reasons, we may not
be able to receive the additional funding that we require to grow our business or we may only be able to obtain it on terms that
substantially dilute your ownership of common stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Additionally,
Covid-19 or similar disasters could interrupt the production of our sole product, FDA approved non-opioid drug Strontium89 (Strontium
Chloride Sr-89 Injection, USP). We only began producing Strontium89 for commercial sale in February 2020, and our sole source for
the raw materials necessary for that product come from Poland. If the Covid-19 or similar disaster interrupts the production or
import of the raw material or otherwise interrupts our production of Strontium89, we will no longer have a product available for
commercial sale.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Our independent registered public
accountant has issued a going concern opinion after auditing our consolidated financial statements; our ability to continue depends
on our ability to raise additional capital and our operations could be curtailed if we are unable to obtain required additional
funding when needed.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We will be required to expend substantial
amounts of working capital in order to acquire and market our proposed products and establish the necessary relationships to implement
our business plan. We were incorporated on November 22, 2013. Our operations to date were funded entirely by capital raised from
our private offering of securities. Notwithstanding the offering, we will continue to require additional financing to execute our
business strategy.&nbsp;&nbsp;We totally depend on external sources of financing for the foreseeable future. Failure to raise additional
funds in the future will adversely affect our business operations, and may require us to suspend our operations, which in turn
may result in a loss to the purchasers of our common stock. We entirely depend on our ability to attract and receive additional
funding from either the sale of securities or the issuance of debt securities. Needed funds might never be available to us on acceptable
terms or at all. The inability to obtain sufficient funding of our operations in the future could restrict our ability to grow
and reduce our ability to continue to conduct business operations.&nbsp;The report of our independent registered public accounting
firm on our consolidated financial statements, included herein, raised substantial doubt about our ability to continue as a going
concern. Our ability to continue as a going concern depends on our ability to raise additional capital. If we are unable to obtain
necessary financing, we will likely be required to curtail our development plans which could cause us to become dormant. Any additional
equity financing may involve substantial dilution to our then existing stockholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I></I></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Our business relies on intellectual
property owned by third parties, and this reliance exposes us to the termination of the right to use that intellectual property
and may result in inadvertent infringement of patents and proprietary rights of others.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Currently, two of our assets are based
on intellectual property that we have licensed from third parties. Our business depends on:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="width: 94%; text-align: justify"><FONT STYLE="font-size: 10pt">our ability to continuously use the technology related to an eye drop treatment for glaucoma, our Mannin platform, that we have licensed from Mannin Research Inc. and</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">our ability to continuously use our intellectual property relating to a chemical compound derived from the plant&nbsp;Solanum Nigrum Linn, also known as Black Nightshade or Makoi, that we seek to use to create a&nbsp;chemotherapeutic agent against&nbsp;liver cancer, our Uttroside platform, and that we have licensed from&nbsp;the Rajiv Gandhi Centre for Biotechnology, an autonomous research institute under the Government of India, known as RGCB, and the Oklahoma Medical Research Foundation, or the OMRF.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If the licenses were to terminate, we would
lose the ability to fully conduct our business pursuant to our plan of operations.&nbsp;&nbsp;Our ability to pursue our business
plan would then depend on finding alternative platforms to license and our non-licensed platforms (SR-89 and QBM-001).&nbsp;&nbsp;We
may not be able to find an attractive platform on a timely and cost effective basis, and even if we did, such platform might be
inferior to the ones we currently have a license to use and may not be attractive to potential customers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Many entities, including some of our competitors,
have or may obtain patents and other intellectual property rights that cover or affect products or services related to those assets
that we license.&nbsp;&nbsp;If a court determines that one or more aspect of the licensed platform infringes on intellectual property
owned by others, we may be required to cease using that platform, to obtain licenses from the owners of the intellectual property
or to redesign the platform in such a way as to avoid infringing the intellectual property rights. If a third party holds intellectual
property rights, it may not allow us to use its intellectual property at any price, which could materially adversely affect our
competitive position.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Mannin platform, SR-89 platform, the
QBM-001 platform and&nbsp;the Uttroside platform may potentially infringe other intellectual property rights. U.S. patent applications
are generally confidential until the Patent and Trademark Office issues a patent. Therefore, we cannot evaluate the extent to which
the licensed platform may infringe claims contained in pending patent applications. Further, without lengthy litigation, it is
often not possible to determine definitively whether a claim of infringement is valid.&nbsp;&nbsp;We may not be in a position to
protect the intellectual property that we license as we are not the owners of that intellectual property and do not currently have
the financial resources to engage in lengthy litigation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Failure to maintain the license for,
or to acquire, the intellectual property underlying any license or sublicense on which our plan of operations is based may force
us to change our plan of operations.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have to meet certain conditions to maintain
the licenses for the intellectual property underlying the Mannin platform and&nbsp;the Uttroside platform and to acquire such intellectual
property. Such conditions include payments of cash and shares of common stock, obtaining certain governmental approvals, initiating
sales of products based on the intellectual property and other matters.&nbsp;We might not have the resources to meet these conditions
and as a result may lose the licenses to the intellectual property that is vital to our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I></I></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We lack an operating history and
have generated minimal revenues to date. If we cannot generate sufficient revenues to operate profitably, we may have to cease
operations.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As we were incorporated on November 22,
2013 and more recently changed business direction, we do not have a sufficient operating history upon which an evaluation of our
future success or failure can be made. Our ability to achieve and maintain profitability and positive cash flow depends upon our
ability to manufacture a product and to earn profit by attracting enough clients who will buy our products or services.&nbsp;&nbsp;We
have missed several expected dates by which we had anticipated to have revenues and have only recently begun to generate minimal
revenues. Even if we substantially increase our revenues, we may never achieve profitability. Failure to generate profits could
eventually cause us to suspend, curtail or cease operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We may be exposed to potential risks
and significant expenses resulting from the requirements under section&nbsp;404 of the Sarbanes-Oxley Act of 2002.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We are required, pursuant to Section 404
of the Sarbanes-Oxley Act of 2002, to include in our annual report our assessment of the effectiveness of our internal control
over financial reporting. We expect to incur significant continuing costs, including accounting fees and staffing costs, in order
to maintain compliance with the internal control requirements of the Sarbanes-Oxley Act of 2002. Our management concluded that
our internal controls and procedures were not effective to detect the inappropriate application of US GAAP for our most recent
fiscal year. As we develop our business, hire employees and consultants and seek to protect our intellectual property rights, our
current design for internal control over financial reporting must be strengthened to enable management to determine that our internal
controls are effective for any period, or on an ongoing basis.&nbsp; Accordingly, as we develop our business, such development
and growth will necessitate changes to our internal control systems, processes and information systems, all of which will require
additional costs and expenses.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In the future, if we fail to complete the
annual Section 404 evaluation in a timely manner, we could be subject to regulatory scrutiny and a loss of public confidence in
our internal controls. In addition, any failure to implement required new or improved controls, or difficulties encountered in
their implementation, could harm our operating results or cause us to fail to meet our reporting obligations.&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Limited oversight of our management
may lead to corporate conflicts.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have only three directors, of whom two
are also officers. Accordingly, we cannot establish board committees comprised of independent members to oversee functions like
compensation or audit issues. In addition, since we only have three directors, they have significant control over all corporate
issues.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Because we are not subject to compliance
with rules requiring the adoption of certain corporate governance measures, our shareholders have limited protections against interested
director transactions, conflicts of interest and similar matters.&nbsp; The Sarbanes-Oxley Act of 2002, as well as rules enacted
by the SEC, the New York Stock Exchange and the Nasdaq Stock Market, requires the implementation of various measures relating to
corporate governance. These measures are designed to enhance the integrity of corporate management and the securities markets and
apply to securities which are listed on the New York Stock Exchanges or the Nasdaq Stock Market. Because we are not presently required
to comply with many of the corporate governance provisions, we have not yet adopted these measures and, currently, would not be
able to comply with such corporate governance provisions. We do not have an audit or compensation committee comprised of independent
directors. Two of our three directors who perform these functions and are not independent directors. Thus, there is a potential
conflict in that our directors are also engaged in management and participate in decisions concerning management compensation and
audit issues that may affect management performance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Until we have a larger board of directors
that would include a majority of independent members, if ever, there will be limited oversight of our directors&rsquo; decisions
and activities and little ability for minority shareholders to challenge or reverse those activities and decisions, even if they
are not in the best interests of minority shareholders.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Additionally, our directors beneficially
own approximately 26% of our common stock. Although it is possible for them to be outvoted by the remaining shareholders at a general
or special meeting if the two directors voted together, the size of their shareholdings and the absence of any other person beneficially
owning more than 10% of our common stock would make this a difficult undertaking.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Because the results of preclinical
studies and early clinical trials are not necessarily predictive of future results, any product candidate we advance into clinical
trials may not have favorable results in later clinical trials, if any, or receive regulatory approval.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Pharmaceutical development has inherent
risk. We will be required to demonstrate through well-controlled clinical trials for our product candidates for our Mannin platform,
the QBM-001 platform and&nbsp;the Uttroside platform and any additional uses based on the SR-89 and Metastron platforms that our
product candidates are effective with a favorable benefit-risk profile for use in their target indications before we can seek regulatory
approvals for their commercial sale. Success in early clinical trials does not mean that later clinical trials will be successful
as product candidates in later-stage clinical trials may fail to demonstrate sufficient safety or efficacy despite having progressed
through initial clinical testing. We also may need to conduct additional clinical trials that are not currently anticipated. Companies
frequently suffer significant setbacks in advanced clinical trials, even after earlier clinical trials have shown promising results.
In addition, only a small percentage of drugs under development result in the submission of a New Drug Application or Biologics
License Application, known as BLA, to the U.S. Food and Drug Administration and even fewer are approved for commercialization.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Any product candidates we advance
into clinical development are subject to extensive regulation, which can be costly and time consuming, cause unanticipated delays
or prevent the receipt of the required approvals to commercialize our product candidates.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The clinical development, manufacturing,
labeling, storage, record-keeping, advertising, promotion, import, export, marketing and distribution of our product candidate,
Man-01, are subject to extensive regulation by the FDA in the United States and by comparable health authorities in foreign markets.
In the United States, we are not permitted to market our product candidates until we receive approval of a BLA from the FDA. The
process of obtaining BLA approval is expensive, often takes many years and can vary substantially based upon the type, complexity
and novelty of the products involved. In addition to the significant clinical testing requirements, our ability to obtain marketing
approval for these products depends on obtaining the final results of required non-clinical testing, including characterization
of the manufactured components of our product candidates and validation of our manufacturing processes. The FDA may determine that
our product manufacturing processes, testing procedures or facilities are insufficient to justify approval. Approval policies or
regulations may change, and the FDA has substantial discretion in the pharmaceutical approval process, including the ability to
delay, limit or deny approval of a product candidate for many reasons. Despite the time and expense invested in clinical development
of product candidates, regulatory approval is never guaranteed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The FDA or another regulatory agency can
delay, limit or deny approval of a product candidate for many reasons, including, but not limited to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="width: 94%; text-align: justify"><FONT STYLE="font-size: 10pt">the FDA or comparable foreign regulatory authorities may disagree with the design or implementation of our clinical trials;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">we may be unable to demonstrate to the satisfaction of the FDA that a product candidate is safe and effective for any indication;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">the FDA may not accept clinical data from trials which are conducted by individual investigators or in countries where the standard of care is potentially different from the United States;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">results of clinical trials may not meet the level of statistical significance required by the FDA for approval;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">we may be unable to demonstrate that a product candidate&rsquo;s clinical and other benefits outweigh its safety risks;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">the FDA may disagree with our interpretation of data from preclinical studies or clinical trials;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">the FDA may fail to approve our manufacturing processes or facilities or those of third-party manufacturers with which we or our collaborators contract for clinical and commercial supplies; or</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">the approval policies or regulations of the FDA may significantly change in a manner rendering our clinical data insufficient for approval.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">With respect to foreign markets, approval
procedures vary among countries and, in addition to the aforementioned risks, can involve additional product testing, administrative
review periods and agreements with pricing authorities. In addition, recent events raising questions about the safety of certain
marketed pharmaceuticals may result in increased cautiousness by the FDA and comparable foreign regulatory authorities in reviewing
new pharmaceuticals based on safety, efficacy or other regulatory considerations and may result in significant delays in obtaining
regulatory approvals. Any delay in obtaining, or inability to obtain, applicable regulatory approvals would prevent us from commercializing
our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Any product candidate we manufacture
or advance into clinical trials may cause unacceptable adverse events or have other properties that may delay or prevent their
regulatory approval or commercialization or limit their commercial potential.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Unacceptable adverse events caused by any
of our product candidates that we manufacture or advance into clinical trials could cause us or regulatory authorities to interrupt,
delay or halt production or clinical trials and could result in the denial of regulatory approval by the FDA or other regulatory
authorities for any or all targeted indications and markets. This, in turn, could prevent us from commercializing the affected
product candidate and generating revenues from its sale.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Except for our Strontium Chloride 89, known
as SR89, and Metastron product candidates, there is not yet completed testing of any of our product candidates for the treatment
of the indications for which we intend to seek product approval in humans, and we currently do not know the extent of adverse events,
if any, that will be observed in patients who receive any of our product candidates. If any of our product candidates cause unacceptable
adverse events in clinical trials, we may not be able to obtain regulatory approval or commercialize such product or, if such product
candidate is approved for marketing, future adverse events could cause us to withdraw such product from the market.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Delays in the commencement of our
clinical trials could result in increased costs and delay our ability to pursue regulatory approval.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The commencement of clinical trials can
be delayed for a variety of reasons, including delays in:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="width: 94%; text-align: justify"><FONT STYLE="font-size: 10pt">obtaining regulatory clearance to commence a clinical trial;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">identifying, recruiting and training suitable clinical investigators;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">reaching agreement on acceptable terms with prospective clinical research organizations (&ldquo;CROs&rdquo;) and trial sites, the terms of which can be subject to extensive negotiation, may be subject to modification from time to time and may vary significantly among different CROs and trial sites;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">obtaining sufficient quantities of a product candidate for use in clinical trials;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">obtaining Investigator Review Board, or IRB, or ethics committee approval to conduct a clinical trial at a prospective site;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">identifying, recruiting and enrolling patients to participate in a clinical trial; and</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">retaining patients who have initiated a clinical trial but may withdraw due to adverse events from the therapy, insufficient efficacy, fatigue with the clinical trial process or personal issues.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Any delays in the commencement of our clinical
trials will delay our ability to pursue regulatory approval for our product candidates. In addition, many of the factors that cause,
or lead to, a delay in the commencement of clinical trials may also ultimately lead to the denial of regulatory approval of a product
candidate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Suspensions or delays in the completion
of clinical testing could result in increased costs to us and delay or prevent our ability to complete development of that product
or generate product revenues.</I></B></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Once a clinical trial has begun, patient
recruitment and enrollment may be slower than we anticipate. Clinical trials may also be delayed as a result of ambiguous or negative
interim results or difficulties in obtaining sufficient quantities of product manufactured in accordance with regulatory requirements
and on a timely basis. Further, a clinical trial may be modified, suspended or terminated by us, an IRB, an ethics committee or
a data safety monitoring committee overseeing the clinical trial, any clinical trial site with respect to that site, or the FDA
or other regulatory authorities due to a number of factors, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="width: 94%; text-align: justify"><FONT STYLE="font-size: 10pt">failure to conduct the clinical trial in accordance with regulatory requirements or our clinical protocols;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">inspection of the clinical trial operations or clinical trial sites by the FDA or other regulatory authorities resulting in the imposition of a clinical hold;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">stopping rules contained in the protocol;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">unforeseen safety issues or any determination that the clinical trial presents unacceptable health risks; and</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">lack of adequate funding to continue the clinical trial.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Changes in regulatory requirements and
guidance also may occur and we may need to amend clinical trial protocols to reflect these changes. Amendments may require us to
resubmit our clinical trial protocols to IRBs for re-examination, which may impact the costs, timing and the likelihood of a successful
completion of a clinical trial. If we experience delays in the completion of, or if we must suspend or terminate, any clinical
trial of any product candidate, our ability to obtain regulatory approval for that product candidate will be delayed and the commercial
prospects, if any, for the product candidate may suffer as a result. In addition, any of these factors may also ultimately lead
to the denial of regulatory approval of a product candidate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Our product candidates (if approved)
or any other product candidates that we may develop and market may be later withdrawn from the market or subject to promotional
limitations.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We may not be able to obtain the labeling
claims necessary or desirable for the promotion of our product candidates if approved. We may also be required to undertake post-marketing
clinical trials. If the results of such post-marketing studies are not satisfactory or if adverse events or other safety issues
arise after approval, the FDA or a comparable regulatory agency in another country may withdraw marketing authorization or may
condition continued marketing on commitments from us that may be expensive and/or time consuming to complete. In addition, if we
or others identify adverse side effects after any of our products are on the market, or if manufacturing problems occur, regulatory
approval may be withdrawn and reformulation of our products, additional clinical trials, changes in labeling of our products and
additional marketing applications may be required. Any reformulation or labeling changes may limit the marketability of our products
if approved.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Our dependence on third party suppliers
or our inability to successfully produce any product could adversely impact our business.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We rely on third parties to supply us with
component and materials required for the development and manufacture of our product and our product candidates. For example, we
receive all of the raw material for our Strontium89 product from the National Centre for Nuclear Research, Radioisotope Centre
(&ldquo;Polatom&rdquo;) in Poland, and we rely on IsoTherapeutics to manufacture that raw material into Strontium89. If any such
third parties fail to provide the required components or we are unable to find a partner to manufacture the necessary products,
there would be a significant interruption of our supply, which would materially adversely affect clinical development and the commercialization
and potential commercialization of our product and product candidates. In the event that the FDA or such other agencies determine
that we or any third-party suppliers have not complied with cGMP, our clinical trials could be terminated or subjected to a clinical
hold until such time as we or any third party are able to obtain appropriate replacement material. Furthermore, if any contract
manufacturers who supply us cannot successfully manufacture material that conforms to our specifications and with FDA regulatory
requirements, we will not be able to secure and/or maintain FDA approval for our product candidates. We, and any third-party suppliers
are and will be required to maintain compliance with cGMPs and will be subject to inspections by the FDA or comparable agencies
in other jurisdictions to confirm such compliance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We do and will also rely on our partners
and manufacturers to purchase from third-party suppliers the materials necessary to produce our product candidates for our anticipated
clinical trials. We do not have any control over the process or timing of the acquisition of raw materials by our manufacturers.
Moreover, we currently do not have any agreements for the commercial production of these raw materials. Any significant delay in
the supply of a product candidate or the raw material components thereof for an ongoing clinical trial could considerably delay
completion of our clinical trials, product testing and potential regulatory approval of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We may not have the resources or capacity
to commercially manufacture our product candidates, and we will likely continue to be dependent upon third party manufacturers.
Our current inability, or our dependence on third parties, to manufacture and supply us with clinical trial materials and any approved
products may adversely affect our ability to develop and commercialize our product candidates on a timely basis or at all.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We intend to contract with third
parties either directly or through our licensors&nbsp;for the manufacture of our product candidates. This reliance on third parties
increases the risk that we will not have sufficient quantities of our product candidates or that such supply will not be available
to us at an acceptable cost, which could delay, prevent or impair our commercialization efforts.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We do not have any manufacturing facilities.
We expect to use third-party manufacturers for the manufacture of our product candidates and have entered into contracts with manufacturers
through the licensor of our radio-pharmaceutical product, SR89. Even with such contracts in place, reliance on third-party manufacturers
entails additional risks, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="width: 94%; text-align: justify"><FONT STYLE="font-size: 10pt">reliance on the third party for regulatory compliance and quality assurance;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">the possible breach of the manufacturing agreement by the third party;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">the possible termination or nonrenewal of the agreement by the third party at a time that is costly or inconvenient for us; and</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">reliance on the third party for regulatory compliance, quality assurance, and safety and pharmacovigilance reporting.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Third-party manufacturers may not be able
to comply with current good manufacturing practices, or cGMP, regulations or similar regulatory requirements outside the United
States. Our failure, or the failure of our third-party manufacturers, to comply with applicable regulations could result in sanctions
being imposed on us, including fines, injunctions, civil penalties, delays, suspension or withdrawal of approvals, license revocation,
seizures or recalls of product candidates or medicines, operating restrictions and criminal prosecutions, any of which could significantly
and adversely affect supplies of our medicines and harm our business and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Any product that we may produce may compete
with other product candidates and products for access to manufacturing facilities. There are a limited number of manufacturers
that operate under cGMP regulations and that might be capable of manufacturing for us.&nbsp;Any performance failure on the part
of future manufacturers could result in a decrease or end to revenue. If any a contract manufacturer cannot perform as agreed,
we may be required to replace that manufacturer. We may incur added costs and delays in identifying and qualifying any such replacement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our anticipated future dependence upon
others for the manufacture of our product candidates may adversely affect our future profit margins and our ability to commercialize
any medicines that receive marketing approval on a timely and competitive basis.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We will likely rely on third parties
to conduct our clinical trials. If these third parties do not meet our deadlines or otherwise conduct the trials as required, our
clinical development programs could be delayed or unsuccessful and we may not be able to obtain regulatory approval for or commercialize
our product candidates when expected or at all.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We do not have the ability to conduct all
aspects of our preclinical testing or clinical trials ourselves. We intend to use, and do use, Mannin, RGCB, OMRF and&nbsp;CROs
to conduct our planned clinical trials and will and do rely upon such CROs, as well as medical institutions, clinical investigators
and consultants, to conduct our trials in accordance with our clinical protocols. Our CROs, investigators and other third parties
will and do play a significant role in the conduct of these trials and the subsequent collection and analysis of data from the
clinical trials.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">There is no guarantee that any CROs, investigators
and other third parties upon which we rely for administration and conduct of our clinical trials will devote adequate time and
resources to such trials or perform as contractually required. If any of these third parties fail to meet expected deadlines, fail
to adhere to our clinical protocols or otherwise perform in a substandard manner, our clinical trials may be extended, delayed
or terminated. If any of our clinical trial sites terminate for any reason, we may experience the loss of follow-up information
on patients enrolled in our ongoing clinical trials unless we are able to transfer the care of those patients to another qualified
clinical trial site. In addition, principal investigators for our clinical trials may serve as scientific advisors or consultants
to us from time to time and receive cash or equity compensation in connection with such services. If these relationships and any
related compensation result in perceived or actual conflicts of interest, the integrity of the data generated at the applicable
clinical trial site may be jeopardized.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>If our competitors develop treatments
for the target indications of our product candidates that are approved more quickly, marketed more successfully or demonstrated
to be more effective than our product candidates, our commercial opportunity will be reduced or eliminated.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We operate in highly competitive segments
of the biotechnology and biopharmaceutical markets. We face competition from many different sources, including commercial pharmaceutical
and biotechnology enterprises, academic institutions, government agencies, and private and public research institutions. Our product
candidates, if successfully manufactured and/or developed and approved, will compete with established therapies, as well as new
treatments that may be introduced by our competitors. Many of our competitors have significantly greater financial, product development,
manufacturing and marketing resources than us. Large pharmaceutical companies have extensive experience in clinical testing and
obtaining regulatory approval for drugs. In addition, many universities and private and public research institutes are active in
cancer research, some in direct competition with us. We also may compete with these organizations to recruit management, scientists
and clinical development personnel. Smaller or early-stage companies may also prove to be significant competitors, particularly
through collaborative arrangements with large and established companies. New developments, including the development of other biological
and pharmaceutical technologies and methods of treating disease, occur in the pharmaceutical and life sciences industries at a
rapid pace. Developments by competitors may render our product candidates obsolete or noncompetitive. We will also face competition
from these third parties in recruiting and retaining qualified personnel, establishing clinical trial sites and patient registration
for clinical trials and in identifying and in-licensing new product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>If competitors introduce their own
generic equivalent of our SR89 product candidates, our revenues and gross margin from such products could decline rapidly.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Revenues and gross margin derived from
generic pharmaceutical products often follow a pattern based on regulatory and competitive factors that we believe are unique to
the generic pharmaceutical industry. As the patent(s) for a brand name product or the statutory marketing exclusivity period (if
any) expires, the first generic manufacturer to receive regulatory approval for a generic equivalent of the product often is able
to capture a substantial share of the market. However, as other generic manufacturers receive regulatory approvals for their own
generic versions, that market share, and the price of that product, will typically decline depending on several factors, including
the number of competitors, the price of the branded product and the pricing strategy of the new competitors. The number of our
competitors producing a generic version equivalent to our SR89 product candidates could increase to such an extent that we may
stop marketing our product for which we previously obtained approval, which would have a material adverse impact on our revenues,
if we ever achieve revenues, and gross margin.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We may expend our limited resources
to pursue a particular product candidate or indication and fail to capitalize on product candidates or indications for which there
may be a greater likelihood of success.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Because we have limited financial and managerial
resources, we will focus on a limited number of research programs and product candidates for specific indications. As a result,
we may forego or delay pursuit of opportunities with other product candidates for other indications for which there may be a greater
likelihood of success or may prove to have greater commercial potential. Notwithstanding our investment to date and anticipated
future expenditures on MAN 01 (Mannin), Uttroside-B (OMRF), QBM001 and&nbsp;SR-89, we have not yet developed, and may never successfully
develop, any marketed treatments using these products other than the SR89 product candidates for which there is FDA approval. Research
programs to identify new product candidates or pursue alternative indications for current product candidates require substantial
technical, financial and human resources. Although we intend to, and do, support certain investigator-sponsored clinical trials
of MAN 01, Uttroside-B, QBM001 evaluating various indications, as well as other uses of SR89, these activities may initially show
promise in identifying potential product candidates or indications, yet fail to yield product candidates or indications for further
clinical development.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We depend upon the services of our
key management personnel, and the loss of their services would likely result in disruptions of our operations and have a material
adverse effect on our business.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our management and operations are dependent
on the services of our management team, namely Mr. Denis Corin, our Chief Executive Officer and Chairman, and Mr. William Rosenstadt,
our Chief Legal Officer and a Director.&nbsp; We do not have employment or non-compete agreements with or maintain key-man life
insurance in respect of either of these individuals.&nbsp; Because of their knowledge of the industry and our operations and their
experience with us, we believe that our future results depend upon their efforts, and the loss of the services of either of these
individuals for any reason could result in a disruption of our operations which will likely have a material adverse effect on our
business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Other than our Chief Executive Officer,
we currently do not have full-time employees, but we retain the services of independent contractors/consultants on a contract-employment
basis. Our ability to manage growth effectively will require us to continue to implement and improve our management systems and
to recruit and train new employees. We might not be able to successfully attract and retain skilled and experienced personnel.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>If we fail to attract and retain
key management and clinical development personnel, we may be unable to successfully develop or commercialize our product candidates.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We will need to expand and effectively
manage our managerial, operational, financial and other resources in order to successfully pursue our clinical development and
commercialization efforts. As a company with a limited number of personnel, we highly depend on the development, regulatory, commercial
and financial expertise of the members of our senior management and advisors, in particular Denis Corin, our chairman and chief
executive officer. The loss of this individual or the services of any of our other senior management could delay or prevent the
further development and potential commercialization of our product candidates and, if we are not successful in finding suitable
replacements, could harm our business. Our success also depends on our continued ability to attract, retain and motivate highly
qualified management and scientific personnel and we may not be able to do so in the future due to the intense competition for
qualified personnel among biotechnology and pharmaceutical companies, as well as universities and research organizations. If we
are not able to attract and retain the necessary personnel, we may experience significant impediments to our ability to implement
our business strategy.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Applicable regulatory requirements,
including those contained in and issued under the Sarbanes-Oxley Act of 2002, may make it difficult for us to retain or attract
qualified officers and directors, which could adversely affect the management of our business and our ability to retain listing
of our common stock.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We may be unable to attract and retain
those qualified officers, directors and members of board committees required to provide for effective management because of the
rules and regulations that govern publicly-held companies, including, but not limited to, certifications by principal executive
officers. The enactment of the Sarbanes-Oxley Act has resulted in the issuance of a series of related rules and regulations and
the strengthening of existing rules and regulations by the SEC, as well as the adoption of new and more stringent rules by the
stock exchanges. The perceived increased personal risk associated with these changes may deter qualified individuals from accepting
roles as directors and executive officers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Further, some of these changes heighten
the requirements for board or committee membership, particularly with respect to an individual&rsquo;s independence from our business
and level of experience in finance and accounting matters. We may have difficulty attracting and retaining directors with the requisite
qualifications. If we are unable to attract and retain qualified officers and directors, the management of our business and our
ability to obtain or retain listing of our shares of common stock on any stock exchange could be adversely affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We may be exposed to potential risks
and significant expenses resulting from the requirements under section&nbsp;404 of the Sarbanes-Oxley Act of 2002.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We are required, pursuant to Section 404
of the Sarbanes-Oxley Act of 2002, to include in our annual report our assessment of the effectiveness of our internal control
over financial reporting. We expect to incur significant continuing costs, including accounting fees and staffing costs, in order
to maintain compliance with the internal control requirements of the Sarbanes-Oxley Act of 2002. Our management concluded that
our internal controls and procedures were not effective to detect the inappropriate application of US GAAP for our most recent
fiscal year. As we develop our business, hire employees and consultants and seek to protect our intellectual property rights, our
current design for internal control over financial reporting must be strengthened to enable management to determine that our internal
controls are effective for any period, or on an ongoing basis.&nbsp; Accordingly, as we develop our business, such development
and growth will necessitate changes to our internal control systems, processes and information systems, all of which will require
additional costs and expenses.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In the future, if we fail to complete the
annual Section 404 evaluation in a timely manner, we could be subject to regulatory scrutiny and a loss of public confidence in
our internal controls. In addition, any failure to implement required new or improved controls, or difficulties encountered in
their implementation, could harm our operating results or cause us to fail to meet our reporting obligations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Because of the small size of our
company, we do not have separate Chairman, Chief Executive Officer and Chief Financial Officer positions, which may expose us to
potential risks, including our failure to produce reliable financial reports and prevent and/or detect fraud.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have not adopted a formal policy to
separate or combine the positions of Chairman and Chief Executive Officer, both of which are currently held by Denis Corin who
is also our acting principal financial officer.&nbsp; In addition, our CEO and CLO also comprise the majority of our Board of Directors.&nbsp;
As such, there is no division of labor between our management and of our Board of Directors.&nbsp; This structure exposes us to
a number of risks, including a failure to maintain adequate internal controls, our failure to produce reliable financial reports
and our failure to prevent and/or detect financial fraud.&nbsp; Any such failures would adversely affect our financial condition
and overall business operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We are required, pursuant to Section 404
of the Sarbanes-Oxley Act of 2002, to include in our annual report our assessment of the effectiveness of our internal control
over financial reporting. We expect to incur significant continuing costs, including accounting fees and staffing costs, in order
to maintain compliance with the internal control requirements of the Sarbanes-Oxley Act of 2002. Our management concluded that
our internal controls and procedures were not effective to detect the inappropriate application of US GAAP for our most recent
fiscal year. As we develop our business, hire employees and consultants and seek to protect our intellectual property rights, our
current design for internal control over financial reporting must be strengthened to enable management to determine that our internal
controls are effective for any period, or on an ongoing basis.&nbsp; Accordingly, as we develop our business, such development
and growth will necessitate changes to our internal control systems, processes and information systems, all of which will require
additional costs and expenses. Among other outcomes, a downturn in general economic conditions could:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="width: 94%; text-align: justify"><FONT STYLE="font-size: 10pt">increase the cost of raising, or decrease our ability to raise, additional funds; as we do not anticipate generating sufficient revenue in the next twelve months to cover our operating costs, we may need to raise additional funding to implement our business if we do not raise sufficient funds in this offering. A recession or other negative economic factors could make this more difficult or prohibitive; or</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">interfere with services provided by third parties; we use third parties for research purposes and intend to use third parties for the production and distribution of our generic SR89 product candidate, and a general recession or other economic conditions could jeopardize the ability of any third parties to fulfill their obligations to us;</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In the future, if we fail to complete the
annual Section 404 evaluation in a timely manner, we could be subject to regulatory scrutiny and a loss of public confidence in
our internal controls. In addition, any failure to implement required new or improved controls, or difficulties encountered in
their implementation, could harm our operating results or cause us to fail to meet our reporting obligations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Two of our assets may compete with
each other and we will need to address how to proceed with each asset</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our Strontium Chloride 89 product from
BNI is the generic version of our Metastron product that we acquired from GE Healthcare Limited. Having two products based on the
same drug for the same bone cancer pain mediation therapy may prove to be redundant. We have not yet decided how to proceed with
these assets if they prove to be redundant, but we may have to abandon one of the products or severely curtail our plans for its
development. Any such abandonment or curtailment would reduce potential income from such product.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I></I></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Risks Related to our Industry</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We are subject to general economic
conditions outside of our control.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Projects for the acquisition and development
of our products are subject to many factors, which are outside our control.&nbsp;&nbsp;These factors include general economic conditions
in North America and worldwide (such as recession, inflation, unemployment, and interest rates), shortages of labor and materials
and price of materials and competitive products and the regulation by federal and state governmental authorities. If any or several
of these facts develop in a way that is adverse to our interest, we will not be in a position to reverse them, and we may not be
able to survive such a development.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>If any product candidate that we
successfully develop does not achieve broad market acceptance among physicians, patients, healthcare payors and the medical community,
the revenues that it generates from their sales will be limited.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Even if we successfully produce product
candidates, they may not gain market acceptance among physicians, patients, healthcare payors and the medical community. Coverage
and reimbursement of our product candidates by third-party payors, including government payors, generally is also necessary for
commercial success. The degree of market acceptance of any approved products will depend on a number of factors, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="width: 94%; padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">the efficacy and safety as demonstrated in clinical trials;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">the clinical indications for which the product is approved;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">acceptance by physicians, major operators of hospitals and clinics and patients of the product as a safe and effective treatment;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">acceptance of the product by the target population;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">the potential and perceived advantages of product candidates over alternative treatments;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">the safety of product candidates seen in a broader patient group, including its use outside the approved indications;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">the cost of treatment in relation to alternative treatments;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">the availability of adequate reimbursement and pricing by third parties and government authorities;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">relative convenience and ease of administration;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">the prevalence and severity of adverse events;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="padding-bottom: 12pt; text-align: justify"><FONT STYLE="font-size: 10pt">the effectiveness of our sales and marketing efforts; and</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">unfavorable publicity relating to the product.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If any product candidate is approved but
does not achieve an adequate level of acceptance by physicians, hospitals, healthcare payors and patients, we may not generate
sufficient revenue from these products and may not become or remain profitable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We may incur substantial product
liability or indemnification claims relating to the clinical testing and/or use of our product candidates.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We face an inherent risk of product liability
exposure related to the testing of our product candidates in human clinical trials, as well as related to the manufacture and consumption
of product candidates that we successfully commercialize. Claims could be brought against us if use or misuse of one of our product
candidates causes, or merely appears to have caused, personal injury or death. We maintain a $5 Million product liability policy.
Such coverage may not be sufficient to cover claims that may be made against us and we may be unable to maintain such insurance.
Any claims against us, regardless of their merit, could severely harm our financial condition, strain our management and other
resources or destroy the prospects for commercialization of the product which is the subject of any such claim. Additionally, we
have entered into various agreements where we indemnify third parties for certain claims relating to our product candidates. These
indemnification obligations may require us to pay significant sums of money for claims that are covered by these indemnifications.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Healthcare reform and restrictions
on reimbursements may limit our financial returns.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our ability or the ability of our collaborators
to commercialize any of our product candidates that we successfully develop may depend, in part, on the extent to which government
health administration authorities, private health insurers and other organizations will reimburse consumers for the cost of these
products. These third parties are increasingly challenging both the need for and the price of new drug products. Significant uncertainty
exists as to the reimbursement status of newly approved therapeutics. Adequate third-party reimbursement may not be available for
our product candidates to enable us or our collaborators to maintain price levels sufficient to realize an appropriate return on
their and our investments in research and product development.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Our success depends upon intellectual
property, proprietary technologies and regulatory market exclusivity periods, and the intellectual property protection for our
product candidates depends significantly on third parties.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our success depends, in large part, on
obtaining and maintaining patent protection and trade secret protection for our product candidates and their formulations and uses,
as well as successfully defending these patents against third-party challenges. The parties from which we license our intellectual
property are responsible for prosecuting and maintaining patent protection relating to the intellectual property to which we have
a license from that party. If any of these parties fails to appropriately prosecute and maintain patent protection for the intellectual
property, our ability to develop and commercialize the respective product candidate may be adversely affected and we may not be
able to prevent competitors from making, using and selling competing products. This failure to properly protect the intellectual
property rights could have a material adverse effect on our financial condition and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The patent application process is subject
to numerous risks and uncertainties, and we or our partners might not be successful in protecting our product candidates by obtaining
and defending patents. These risks and uncertainties include the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="width: 94%; text-align: justify"><FONT STYLE="font-size: 10pt">patent applications may not result in any patents being issued;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">patents that may be issued or in-licensed may be challenged, invalidated, modified, revoked, circumvented, found to be unenforceable, or otherwise may not provide any competitive advantage;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">our competitors, many of which have substantially greater resources than we or our partners and many of which have made significant investments in competing technologies, may seek, or may already have obtained, patents that will limit, interfere with, or eliminate our ability to make, use and sell our potential products;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">there may be significant pressure on the U.S. government and other international governmental bodies to limit the scope of patent protection both inside and outside the United States for disease treatments that prove successful as a matter of public policy regarding worldwide health concerns; and</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">countries other than the United States may have patent laws less favorable to patentees than those upheld by U.S. courts, allowing foreign competitors a better opportunity to create, develop, and market competing products.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In addition to patents, we and our partners
also rely on trade secrets and proprietary know-how. Although we have taken steps to protect our trade secrets and unpatented know-how,
including entering into confidentiality agreements with third parties, and confidential information and inventions agreements with
employees, consultants and advisors, third parties may still obtain this information or come upon this same or similar information
independently.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We also intend to rely on our ability to
obtain and maintain a regulatory period of market exclusivity for any of our biologic product candidates that are successfully
developed and approved for commercialization. Although this period in the United States is currently 12 years from the date of
marketing approval, there is a risk that the U.S. Congress could amend laws to significantly shorten this exclusivity period. Once
any regulatory period of exclusivity expires, depending on the status of our patent coverage and the nature of the product, we
may not be able to prevent others from marketing products that are biosimilar to or interchangeable with our products, which would
materially adversely affect us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In addition, U.S. patent laws may change
which could prevent or limit us from filing patent applications or patent claims to protect our products and/or technologies or
limit the exclusivity periods that are available to patent holders. For example, on September&nbsp;16, 2011, the Leahy-Smith America
Invents Act, or the America Invents Act, was signed into law, and includes a number of significant changes to U.S. patent law.
These include changes to transition from a &ldquo;first-to-invent&rdquo; system to a &ldquo;first-to-file&rdquo; system and to
the way issued patents are challenged. These changes may favor larger and more established companies that have more resources to
devote to patent application filing and prosecution. The U.S. Patent and Trademark Office implemented the America Invents Act on
March&nbsp;16, 2013, and it remains to be seen how the judicial system and the U.S. Patent and Trademark Office will interpret
and enforce these new laws. Accordingly, it is not clear what impact, if any, the America Invents Act will ultimately have on the
cost of prosecuting our patent applications, our ability to obtain patents based on our discoveries and our ability to enforce
or defend our issued patents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>If we or our partners are sued for
infringing intellectual property rights of third parties, it will be costly and time consuming, and an unfavorable outcome in that
litigation would have a material adverse effect on our business.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our success also depends on our ability
and the ability of any of our current or future collaborators to develop, manufacture, market and sell our product candidates without
infringing the proprietary rights of third parties. Numerous U.S. and foreign issued patents and pending patent applications, which
are owned by third parties, exist in the fields in which we are developing products, some of which may be directed at claims that
overlap with the subject matter of our intellectual property. Because patent applications can take many years to issue, there may
be currently pending applications, unknown to us, which may later result in issued patents that our product candidates or proprietary
technologies may infringe. Similarly, there may be issued patents relevant to our product candidates of which we are not aware.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">There is a substantial amount of litigation
involving patent and other intellectual property rights in the biotechnology and biopharmaceutical industries generally. If a third-party
claims that we or any of our licensors, suppliers or collaborators infringe the third party&rsquo;s intellectual property rights,
we may have to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="width: 94%; text-align: justify"><FONT STYLE="font-size: 10pt">obtain licenses, which may not be available on commercially reasonable terms, if at all;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">abandon an infringing product candidate or redesign our products or processes to avoid infringement;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">pay substantial damages, including the possibility of treble damages and attorneys&rsquo; fees, if a court decides that the product or proprietary technology at issue infringes on or violates the third party&rsquo;s rights;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">pay substantial royalties, fees and/or grant cross licenses to our technology; and/or</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">defend litigation or administrative proceedings which may be costly whether we win or lose, and which could result in a substantial diversion of our financial and management resources.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We may be involved in lawsuits to
protect or enforce our patents or the patents of our licensors, which could be expensive, time consuming and unsuccessful.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Competitors may infringe our patents or
the patents of our licensors. To counter infringement or unauthorized use, we may be required to file infringement claims, which
can be expensive and time-consuming. An adverse result in any litigation or defense proceedings could put one or more of our patents
at risk of being invalidated, found to be unenforceable, or interpreted narrowly and could put our patent applications at risk
of not issuing. Furthermore, because of the substantial amount of discovery required in connection with intellectual property litigation,
there is a risk that some of our confidential information could be compromised by disclosure during this type of litigation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I></I></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>We may be subject to claims that
our consultants or independent contractors have wrongfully used or disclosed alleged trade secrets of their other clients or former
employers to us.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As is common in the biotechnology and pharmaceutical
industry, we engage the services of consultants to assist us in the development of our product candidates. Many of these consultants
were previously employed at, or may have previously been or are currently providing consulting services to, other biotechnology
or pharmaceutical companies, including our competitors or potential competitors. We may become subject to claims that we or these
consultants have inadvertently or otherwise used or disclosed trade secrets or other proprietary information of their former employers
or their former or current customers. Litigation may be necessary to defend against these claims. Even if we are successful in
defending against these claims, litigation could result in substantial costs and be a distraction to management.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Risks Related to our Securities</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><B><I>Our shares
of common stock are subject to the &ldquo;penny stock&rsquo; rules of the securities and exchange commission and the trading market
in our securities will be limited, which will make transactions in our stock cumbersome and may reduce the value of an investment
in our stock.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.75in; background-color: white"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">The U.S. Securities
and Exchange Commission (the &ldquo;SEC&rdquo;) has adopted rules that regulate broker-dealer practices in connection with transactions
in &quot;penny stocks.&rdquo;&nbsp; Penny stocks generally are equity securities with a price of less than $5 (other than securities
registered on certain national securities exchanges or quoted on the NASDAQ system, provided that current price and volume information
with respect to transactions in such securities is provided by the exchange or system).&nbsp; Penny stock rules require a broker-dealer,
prior to a transaction in a penny stock not otherwise exempt from those rules, to deliver a standardized risk disclosure document
prepared by the SEC, which specifies information about penny stocks and the nature and significance of risks of the penny stock
market.&nbsp; A broker-dealer must also provide the customer with bid and offer quotations for the penny stock, the compensation
of the broker-dealer, and sales person in the transaction, and monthly account statements indicating the market value of each penny
stock held in the customer's account.&nbsp; In addition, the penny stock rules require that, prior to a transaction in a penny
stock not otherwise exempt from those rules, the broker-dealer must make a special written determination that the penny stock is
a suitable investment for the purchaser and receive the purchaser's written agreement to the transaction.&nbsp; These disclosure
requirements may have the effect of reducing the trading activity in the secondary market for stock that becomes subject to those
penny stock rules.&nbsp; If a trading market for our common stock develops, our common stock will probably become subject to the
penny stock rules, and shareholders may have difficulty in selling their shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;<B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><B><I>Any additional
financing may dilute existing shareholders and decrease the market price for shares of our common stock.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">If we raise additional
capital, our existing shareholders may incur substantial and immediate dilution. We estimate that we will need approximately $4,000,000
in additional&nbsp;funds over the next year for our business plan. The most likely source of future funds available to us is through
the sale of additional shares of common stock. Such sales might occur below market price and below the price of which existing
shareholders purchased their shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><B><I>Our Articles
of Incorporation provide indemnification for officers, directors and employees.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Our governing
instruments provide that officers, directors, employees and other agents and their affiliates shall only be liable to our Company
for losses, judgments, liabilities and expenses that result from the negligence, misconduct, fraud or other breach of fiduciary
obligations. Thus, certain alleged errors or omissions might not be actionable by us. The governing instruments also provide that,
under the broadest circumstances allowed under law, we must indemnify our officers, directors, employees and other agents and their
affiliates for losses, judgments, liabilities, expenses and amounts paid in settlement of any claims sustained by them in connection
with our Company, including liabilities under applicable securities laws.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><B><I>The market
price of our common stock may be volatile and may fluctuate in a way that is disproportionate to our operating performance.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Our shares of
common stock trading on the OTCQB will fluctuate significantly. There is a volatility associated with Bulletin Board securities
in general and the value of your investment could decline due to the impact of any of the following factors upon the market price
of our common stock:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">sales or potential sales of substantial amounts of our
common stock;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">delay or failure in initiating or completing pre-clinical
or clinical trials or unsatisfactory results of these trials;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">announcements about us or about our competitors, including
clinical trial results, regulatory approvals or new product introductions;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">developments concerning our licensors, product manufacturers
or our ability to produce Man-01;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">developments concerning our licensors, product manufacturers
or our ability to produce SR89;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">litigation and other developments relating to our patents
or other proprietary rights or those of our competitors;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">conditions in the pharmaceutical or biotechnology industries;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">governmental regulation and legislation;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">variations in our anticipated or actual operating results;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">change in securities analysts&rsquo; estimates of our
performance, or our failure to meet analysts&rsquo; expectations;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">change in general economic trends; and</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">investor perception of our industry or our prospects.</TD>
</TR></TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Many of these
factors are beyond our control. The stock markets in general, and the market for pharmaceutical and biotechnological companies
in particular, have historically experienced extreme price and volume fluctuations. These fluctuations often have been unrelated
or disproportionate to the operating performance of these companies. These broad market and industry factors could reduce the market
price of our common stock, regardless of our actual operating performance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><B><I>Sales of
a substantial number of shares of our common stock, or the perception that such sales may occur, may adversely impact the price
of our common stock.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">A large number
of our shares may be sold without restriction in public markets. These include:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">approximately 15,416,497 of our outstanding shares of common stock recorded by our transfer agent
as of April 17, 2020 as unrestricted and freely tradable;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">shares of our common stock (including certain shares underlying warrants and convertible debentures)
that are, or are eligible to be, unrestricted and free trading pursuant to Rule 144 or other exemptions from registration under
the Securities Act that have not yet been recorded by our transfer agent as such;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">up to <FONT STYLE="background-color: white">1,711,875</FONT> shares underlying warrants that were
included on a registration declared effective by the SEC on January 12, 2018;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">up to <FONT STYLE="background-color: white">953,249&nbsp;</FONT> shares underlying warrants that
were included on a registration declared effective by the SEC on September 26, 2017; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">upon the effectiveness of the registration statement of which this prospectus forms a part, up
to an additional 5,000,000 shares (approximately 22.3% of our issued and outstanding shares as of April 17, 2020).</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">A large portion
of the shares that are freely tradable, were issued at a price that is significantly below the closing price of $2.07 as of April
17, 2020. If the holders of our free trading shares wanted to make a profit on their investment (or if they wish to sell for a
loss), there might not be enough purchasers to maintain the market price of our common stock on the date of such sales.&nbsp; Any
such sales, or the fear of such sales, could substantially decrease the market price of our common stock and the value of your
investment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><B>The exercise
of warrants or options and the conversion of Preferred Shares or future sales of our common stock may further dilute the shares
of common stock you receive in this offering.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">As of the date
hereof, we have outstanding vested and unvested options and warrants exercisable into 11,020,000 shares of common stock, outstanding
Preferred Shares convertible into a maximum of 16,140,917 shares of common stock (assuming conversion at the floor price of the
respective Preferred Shares and excluding any shares that may be issued upon payments of dividends on such Preferred Shares) and
convertible debentures convertible into approximately 1,250,000 shares of our common stock at the lowest possible conversion prices.
The issuance of any shares of common stock pursuant to exercise of such options and warrants or the conversion of such notes would
dilute your percentage ownership of our Company, and the issuance of any shares of common stock pursuant to exercise of such options
and warrants or the conversion of such notes at a per share price below the offering price of shares being acquired in this offering
which would dilute the net tangible value per share for such investor.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Our Board of Directors
is authorized to sell additional shares of common stock, or securities convertible into shares of common stock, if in their discretion
they determine that such action would be beneficial to us. Approximately 95% of our authorized shares of common stock and 100%
of our shares of preferred stock are available for issuance.&nbsp; Any such issuance would dilute the ownership interest of persons
acquiring common stock in this offering, and any such issuance at a share price lower than then net tangible book value per share
at the time an investor purchased its shares would dilute the net tangible value per share for such investor.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="A3"></A><B>USE OF PROCEEDS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">We will not receive
any proceeds from the conversion of the Preferred Shares or from the sale of the Conversion Shares by the selling stockholder.
Between April 6 and April 17, 2020, however, we sold the Preferred Shares (which account for the Conversion Shares being sold by
this Prospectus) for gross proceeds of $6,797,000. Our gross proceeds consisted of cash and outstanding convertible debentures.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify; background-color: white">Of our gross
proceeds, $4,000,000 were in cash. We intend to use the cash proceeds from the sale of the Preferred Shares for general working
capital, but we will retain broad discretion over the use of these proceeds.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Our gross proceeds
in the form of our outstanding convertible debentures consisted of:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 18.1pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify; padding-right: 0.1pt">$765,656 of principal and interest on a convertible debenture issued on November
1, 2018; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">$2,031,342 of principal and interest in convertible debentures issued on December 6, 2019 and January
15, 2020.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We received net proceeds (excluding our
expenses) of $6,782,000 from the sale of Preferred Shares under the Purchase Agreement, of which $3,985,000 was in cash.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Amount of Proceeds from Sale of Preferred
Shares </I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On April 6, 2020, we entered into a Purchase
Agreement pursuant to which we sold 176,566 Series A Preferred Shares and 503,134 Series B Preferred Shares, all of which we sold
to the selling stockholder, in exchange for gross proceeds of $6,797,000 (which included $2,797,000 of principal and interest on
outstanding convertible debentures held by the selling stockholder). In connection with those sales, we have paid a due diligence
fee of $15,000 for net proceeds of $6,782,000. We are required to pay a dividend on the Preferred Shares that comes out to 8% on
an annual basis, which dividend is to be paid in shares of our common stock. The following table sets out the payments we have
made and may have to make in both the first year and second year of each class of Preferred Shares (excluding any penalty we may
have to pay if we fail to deliver Conversion Shares on a timely basis and the holders buy such equivalent shares, which penalty
cannot be calculated until there is such a buy-in).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">First Year of Series A Preferred Shares</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">First Year of Series B Preferred Shares</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">First Year Total</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">First Two Years of Series A Preferred Shares</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">First Two Years of Series B Preferred Shares</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">First Two Years Total</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 16%; font-size: 10pt; text-align: justify; padding-bottom: 1pt; padding-left: 0.1pt">Due Diligence Fee</TD><TD STYLE="width: 2%; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">-</TD><TD STYLE="width: 1%; padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">-</TD><TD STYLE="width: 1%; padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">15,000</TD><TD STYLE="width: 1%; padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">-</TD><TD STYLE="width: 1%; padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">-</TD><TD STYLE="width: 1%; padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">15,000</TD><TD STYLE="width: 1%; padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-bottom: 1pt; padding-left: 0.1pt">Dividend</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">141,253</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">402,507</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">543,760</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">282,506</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">805,014</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">1,087,520</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-bottom: 1pt; padding-left: 0.1pt">Total:</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">558,760</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">1,103,520</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; background-color: white">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px; padding-right: 0.1pt; padding-bottom: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD STYLE="padding-right: 0.1pt; padding-bottom: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">All of the Preferred Shares have an annual dividend of 8% payable in common stock.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;&nbsp;</P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following sets forth the gross proceeds
paid to us in connection with our issuance of the Preferred Shares, all payments that have been made or that may be required to
be made by us in connection with the issuance of the Preferred Shares in their first year, our resulting minimum net proceeds and
the combined total possible profit to be realized as a result of any conversion discounts regarding the common stock underlying
the Preferred Shares in their first year.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 86%; font-size: 10pt; text-align: justify; padding-left: 0.1pt">Gross proceeds to the Company</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">6,797,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-left: 0.1pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-left: 0.1pt">All payments that have been made or that may be required to be made by the Company to a selling stockholder in the first year of the Preferred Shares</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">558,760</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-left: 0.1pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-left: 0.1pt">Net proceeds to the Company if we make all such payments to a selling stockholder</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">6,238,240</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-left: 0.1pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-left: 0.1pt">All payments that have been made or that may be required to be made by the Company to a selling stockholder in the first year of the Preferred Shares as a percentage of net proceeds</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">9.0</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-left: 0.1pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-left: 0.1pt">The combined total possible profit to be realized as a result of any conversion discounts regarding the securities underlying the Preferred Shares (1)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">3,659,225</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-left: 0.1pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: justify; padding-left: 0.1pt">The combined total possible profit to be realized as a result of any conversion discounts regarding the securities underlying the Preferred Shares as a percentage of net proceeds</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">59.2</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(1)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">As calculated in &ldquo;Selling
Stockholder -&nbsp;Potential Profits to Selling Stockholder<I>&rdquo;</I>&nbsp;using the date of issuance as the conversion date
for each tranche. The actual profit as a result of the conversion discount cannot be calculated until conversion as the conversion
price depends on market conditions at and before conversion, and it may be significantly greater.</FONT></TD>
</TR></TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="A4"></A><B>DETERMINATION OF OFFERING PRICE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">The selling stockholder
will offer common stock at the prevailing market prices or privately negotiated price. The offering price of our common stock does
not necessarily bear any relationship to our book value, assets, past operating results, financial condition or any other established
criteria of value. Our common stock might not trade at market prices in excess of the offering price as prices for common stock
in any public market will be determined in the marketplace and may be influenced by many factors, including the depth and liquidity.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="A5"></A>PLAN OF DISTRIBUTION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The common stock held by the selling stockholder
may be sold or distributed from time to time by the selling stockholder directly to one or more purchasers or through brokers,
dealers, or underwriters who may act solely as agents at market prices prevailing at the time of sale, at prices related to the
prevailing market prices, at negotiated prices, or at fixed prices, which may be changed on any stock exchange, market or trading
facility on which the shares are traded or in private transactions. The sale of the selling stockholder&rsquo;s common stock offered
by this prospectus may be&nbsp;effected&nbsp;in one or more of the following methods:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">ordinary&nbsp;brokerage transactions and transactions
in which the broker-dealer solicits purchasers;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">transactions&nbsp;involving cross or block trades;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">a purchases by a broker-dealer as principal and resale
by the broker-dealer for its account;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">an&nbsp;exchange distribution in accordance with the
rules of the applicable exchange;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">in&nbsp;privately negotiated transactions;</TD>
</TR></TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">broker-dealers may agree with the selling stockholder
to sell a specified number of such shares at a stipulated price per share;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">&ldquo;at the market&rdquo; into an existing market for
the common stock;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">through&nbsp;the writing of options on the shares;</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">a&nbsp;combination of any such methods of sale; and</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">any&nbsp;other method permitted pursuant to applicable
law.</TD>
</TR></TABLE>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In order to comply with the securities
laws of certain states, if applicable, the shares of the selling stockholder may be sold only through registered or licensed brokers
or dealers. In addition, in certain states, such shares may not be sold unless they have been registered or qualified for sale
in the state or an exemption from the registration or qualification requirement is available and complied with.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The selling stockholder may also sell shares
of common stock under Rule 144 promulgated under the Securities Act, if available, or any other exemption available under the Securities
Act rather than under this prospectus. In addition, the selling stockholder may transfer the shares of common stock by other means
not described in this prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The selling stockholder may also sell the
shares directly to market makers acting as principals and/or broker-dealers acting as agents for themselves or their customers.
Such broker-dealers may receive compensation in the form of discounts, concessions or commissions from the selling stockholder
and/or the purchasers of shares for whom such broker-dealers may act as agents or to whom they sell as principal or both, which
compensation as to a particular broker-dealer might be in excess of customary commissions. Market makers and block purchasers purchasing
the shares will do so for their own account and at their own risk. It is possible that the selling stockholder will attempt to
sell shares of common stock in block transactions to market makers or other purchasers at a price per share which may be below
the then market price. The selling stockholder cannot assure that all or any of the shares offered in this prospectus will be issued
to, or sold by, it.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Brokers, dealers or agents participating
in the distribution of the shares held by a selling stockholder as agents may receive compensation in the form of commissions,
discounts, or concessions from the selling stockholder and/or purchasers of the common stock for whom the broker-dealers may act
as agent.&nbsp; Such selling stockholder may agree to indemnify any agent, dealer or broker-dealer that participates in transactions
involving sales of the shares if liabilities are imposed on that person under the Securities Act.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Each selling stockholder acquired the securities
offered hereby in the ordinary course of business and has advised us that it has not entered into any agreements, understandings
or arrangements with any underwriters or broker-dealers regarding the&nbsp;sale of their shares of common stock, nor is there an
underwriter or coordinating broker acting in connection with a proposed sale of shares of common stock by such selling stockholder.
If we are notified by a selling stockholder that any material arrangement has been entered into with a broker-dealer for the sale
of shares of common stock, if required, we will file a supplement to this prospectus.&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We may suspend the sale of shares by a
selling stockholder pursuant to this prospectus for certain periods of time for certain reasons, including if the prospectus is
required to be supplemented or amended to include additional material information.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If a selling stockholder use this prospectus
for any sale of the shares of common stock, it will be subject to the prospectus delivery requirements of the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>Regulation M</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The anti-manipulation rules of Regulation
M under the Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;) may apply to sales of our common stock and activities
of a selling stockholder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have advised the selling stockholder
that while it is engaged in a distribution of the shares included in this prospectus, it is required to comply with Regulation
M promulgated under the Exchange Act. With certain exceptions, Regulation M precludes the selling stockholder, any affiliated purchasers,
and any broker-dealer or other person who participates in the distribution from bidding for or purchasing, or attempting to induce
any person to bid for or purchase any security which is the subject of the distribution until the entire distribution is complete.
Regulation M also prohibits any bids or purchases made in order to stabilize the price of a security in connection with the distribution
of that security. All of the foregoing may affect the marketability of the shares offered hereby this prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="A6"></A>DESCRIPTION OF SECURITIES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>General</B>&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As of April 17, 2020, we are authorized
by our articles of incorporation to issue (i) 250,000,000 shares of common stock, par value $0.001 per share, of which 22,468,185
were outstanding, and (ii) 100,000,000 shares of preferred stock of which (a) 500,000 Series A Preferred Shares were authorized
and 176,566 were outstanding, (b) 1,000,000 Series B Preferred Shares were authorized and 503,134 were outstanding and (c) no other
class of preferred shares was authorized or outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This prospectus contains only a summary
of the common stock the selling stockholder is offering. The following summary of the terms of our common stock and preferred stock,
respectively, may not be complete and is subject to, and qualified in its entirety by reference to, the terms and provisions of
our amended and restated articles of incorporation and our amended and restated bylaws. You should refer to, and read this summary
together with, our amended and restated articles of incorporation and amended and restated bylaws to review all of the terms of
our common stock and preferred stock, respectively, that may be important to you.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Common Stock</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Holders of our common stock are entitled
to one vote for each share held of record on each matter submitted to a vote of stockholders. Except as otherwise required by Nevada
law, and subject to the rights of the holders of preferred stock, if any, all stockholder action is taken by the vote of a majority
of the outstanding shares of common stock voting as a single class present at a meeting of stockholders at which a quorum consisting
of one-half of the outstanding shares of common stock is present in person or proxy.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Subject to the prior rights of any class
or series of preferred stock which may from time to time be outstanding, if any, holders of our common stock are entitled to receive
ratably, dividends when, as, and if declared by our board of directors out of funds legally available for that purpose and, upon
our liquidation, dissolution, or winding up, are entitled to share ratably in all assets remaining after payment of liabilities
and payment of accrued dividends and liquidation preferences on the preferred stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Series A Preferred Shares</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following is a summary of the rights
of the holders of the Series A Preferred Shares. All dollar amounts set out below shall be adjusted proportionally upon the occurrence
of any stock split or common stock dividend</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Voting</I>. Except to the extent required
by law, the holders of the Series A Preferred Shares do not have the right to vote on the matters that the holders of the common
stock have the right to vote upon. The holders of the Series A Preferred Shares may vote upon matters affecting the Series A Preferred
Shares, provided that if the vote concerns all Preferred Shares, the holders of the Series A Preferred Shares shall vote together
with the holders of the Series B Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Liquidation</I>. The holders of the
Series A Preferred Shares, together with the holders of the Series B Preferred Shares, shall have a liquidation preference over
the holders of the common stock. Such preference consists of the right to receive upon our voluntary or involuntary liquidation,
dissolution or winding up the liquidation value of each Series A Preferred Share prior to the payment of any amounts to the holders
of the common stock. The liquidation value of each Series A Preferred Share shall be equal to $10 plus any accrued but unpaid dividends
thereon.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Dividends</I>. Every three months, we
are required to pay each holder of Series A Preferred Shares a dividend equal to 2% of the liquidation value of such shares (which
is equal to 8% on annual basis). Such dividends shall be paid in shares of our common stock in an amount equal to the dollar amount
of such payment divided by the VWAP of our common stock on the date that such dividend payment is due, provided that we may not
issue such shares of common stock if such share issuance would cause the holder to beneficially own more than 9.99% of our common
stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-align: justify"><I>Conversion</I>. Each Series
A Preferred Share may be converted into shares of our common stock in an amount that is equal to the liquidation value divided
by $1.00. We may force the conversion of the Series A Preferred Shares if each of the following conditions (the &ldquo;Forced Equity
Conditions&rdquo;) has been met:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 18pt"></TD><TD STYLE="width: 18.1pt">(i)</TD><TD STYLE="text-align: justify; padding-right: 0.1pt">on each trading day during the period beginning ten trading days prior to
the forced conversion (the &quot;Equity Conditions Measuring Period&quot;), the VWAP of our common stock is in excess of $5.00,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 18pt"></TD><TD STYLE="width: 18.1pt">(ii)</TD><TD STYLE="text-align: justify; padding-right: 0.1pt">on each trading day during Equity Conditions Measuring Period, the dollar
volume of our common stock traded is in excess of $750,000,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 18pt"></TD><TD STYLE="width: 18.1pt">(iii)</TD><TD STYLE="text-align: justify; padding-right: 0.1pt">on each day during the Equity Conditions Measuring Period, the shares of
our common stock underlying the Series A Preferred Shares to be converted shall either (x) be registered for resale on an effective
registration statement or (y) eligible for resale without restriction and without the need for registration under any applicable
federal or state securities laws,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 18pt"></TD><TD STYLE="width: 18.1pt">(iv)</TD><TD STYLE="text-align: justify; padding-right: 0.1pt">on each day during the Equity Conditions Measuring Period, our common stock
is designated for quotation on our principal market and shall not have been suspended from trading on such exchange or market nor
shall delisting or suspension by such exchange or market been threatened or pending either (A) in writing by such exchange or market
or (B) by falling below the then effective minimum listing maintenance requirements of such exchange or market; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 18pt"></TD><TD STYLE="width: 18.1pt">(v)</TD><TD STYLE="text-align: justify; padding-right: 0.1pt">during the Equity Conditions Measuring Period, there shall not have occurred
either (A) an Event of Default or (B) an event that with the passage of time or giving of notice would constitute an Event of Default.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2pt 0pt 0; text-align: justify">We may not issue those shares
of common stock pursuant to the conversions discussed above that would cause a holder to beneficially own more than 9.99% of our
then outstanding common stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2pt 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2pt 0pt 0; text-align: justify">If we fail to issue and deliver
Conversion Shares by three trading days after receiving a conversion notice and such holder purchases common stock to deliver in
satisfaction of a sale by such holder of such Conversion Shares, then we shall, at such holder's discretion, either (i) pay cash
to such holder in an amount equal to such holder's total purchase price for the shares of common stock so purchased (the&nbsp;<B>&quot;</B><U>Buy-In
Price</U><B>&quot;</B>), at which point our obligation to deliver issue and deliver such shares shall terminate, or (ii) promptly
honor our obligation to deliver to such Conversion Shares and pay cash to such holder in an amount equal to the excess (if any)
of the Buy-In Price over the product of (A) such Conversion Shares times (B) the closing bid price on the conversion date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2pt 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Negative Covenants</I>. Until (i) the
liquidation value of the Preferred Shares is less than $1,000,000 or (ii) the Forced Conversion Conditions have been met, we may
not take the following actions, among others (the &ldquo;Restricted Actions&rdquo;), without the affirmative vote of a majority
of the holders of the Preferred Shares:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(i)</TD><TD STYLE="text-align: justify">Create, issue, or reclassify any existing shares of capital stock that (a) are senior to, or have
a liquidation preference over, the Preferred Shares, (b) contain any dividend or conversion rights that are preferential to the
dividend rights of the Preferred Shares or (c) are redeemable;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(ii)</TD><TD STYLE="text-align: justify">Create, incur, assume or suffer to exist any indebtedness or similar obligations, excluding, among
other matters, (a) any indebtedness existing on the initial date of the filing of the Certificate of Designations, (b) indebtedness
to trade creditors incurred in the ordinary course of business, (c) indebtedness associated with acquiring new intellectual property
assets and licenses, so long as the proceeds are going to the party(ies) from which we are acquiring the assets, licenses, and
other properties (vi) any indebtedness not existing at the time hereof and not otherwise permitted not to exceed an aggregate of
$500,000 at any one time;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(iii)</TD><TD STYLE="text-align: justify">Create or permit to a lien or similar encumberment other than such liens customarily permitted
for our continued operation;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(iv)</TD><TD STYLE="text-align: justify">By merger, consolidation, sale, lease back or other similar transaction (a) sell, transfer or dispose
of 25% or more of our assets, (b) permit the issuance or transfer of more than 25% of our voting control in a single transaction
or series of related transaction or (c) which results in our becoming privately held; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(vi)</TD><TD STYLE="text-align: justify">Redeem any shares of our capital stock.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Series B Preferred Shares</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following is a summary of the rights
of the holders of the Series B Preferred Shares. All dollar amounts set out below shall be adjusted proportionally upon the occurrence
of any stock split or common stock dividend</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Voting</I>. Except to the extent required
by law, the holders of the Series B Preferred Shares do not have the right to vote on the matters that the holders of the common
stock have the right to vote upon. The holders of the Series B Preferred Shares may vote upon matters affecting the Series B Preferred
Shares, provided that if the vote concerns all Preferred Shares, the holders of the Series B Preferred Shares shall vote together
with the holders of the Series B Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Liquidation</I>. The holders of the
Series B Preferred Shares, together with the holders of the Series B Preferred Shares, shall have a liquidation preference over
the holders of the common stock. Such preference consists of the right to receive upon our voluntary or involuntary liquidation,
dissolution or winding up the liquidation value of each Series B Preferred Share prior to the payment of any amounts to the holders
of the common stock. The liquidation value of each Series B Preferred Share shall be equal to $10 plus any accrued but unpaid dividends
thereon.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Dividends</I>. Every three months, we
are required to pay each holder of Series B Preferred Shares a dividend equal to 2% of the liquidation value of such shares (which
is equal to 8% on annual basis). Such dividends shall be paid in shares of our common stock in an amount equal to the dollar amount
of such payment divided by the VWAP of our common stock on the date that such dividend payment is due, provided that we may not
issue such shares of common stock if such share issuance would cause the holder to beneficially own more than 9.99% of our common
stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.2pt; text-align: justify"><I>Conversion</I>. Each Series
B Preferred Share may be converted into shares of our common stock in an amount that is equal to the liquidation value divided
by the applicable conversion rate. The conversion rate shall be <FONT STYLE="background-color: white">the lower of: (a) $2.70 or
(b) 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately preceding the conversion
date, provided that the conversion price may not be less than $1.00; further provided that if the VWAP of our common stock for
any 40 consecutive trading days is less than $1.00 for 30 of those days, then such floor conversion price shall be reduced from
$1.00 to $0.35.&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.2pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.2pt; text-align: justify">We may force the conversion of
the Series B Preferred Shares if each of the Forced Equity Conditions has been met.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2pt 0pt 0; text-align: justify">We may not issue those shares
of common stock pursuant to the conversions discussed above that would cause a holder to beneficially own more than 9.99% of our
then outstanding common stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2pt 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2pt 0pt 0; text-align: justify">If we fail to issue and deliver
Conversion Shares by three trading days after receiving a conversion notice and such holder purchases common stock to deliver in
satisfaction of a sale by such holder of such Conversion Shares, then we shall, at such holder's discretion, either (i) pay cash
to such holder in an amount equal the&nbsp;Buy-In Price, at which point our obligation to deliver issue and deliver such shares
shall terminate, or (ii) promptly honor our obligation to deliver to such Conversion Shares and pay cash to such holder in an amount
equal to the excess (if any) of the Buy-In Price over the product of (A) such Conversion Shares times (B) the closing bid price
on the conversion date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2pt 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Negative Covenants</I>. Until (i) the
liquidation value of the Preferred Shares is less than $1,000,000 or (ii) the Forced Conversion Conditions have been met, we may
not take the Restricted Actions without the affirmative vote of a majority of the holders of the Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><B>Anti-Takeover Provisions</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The provisions of Nevada law and our bylaws
may have the effect of delaying, deferring or preventing another party from acquiring control of the company. These provisions
may discourage and prevent coercive takeover practices and inadequate takeover bids.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Nevada Law</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Nevada law contains a provision governing
 &ldquo;acquisition of controlling interest.&rdquo; This law provides generally that any person or entity that acquires 20% or more
of the outstanding voting shares of a publicly-held Nevada corporation in the secondary public or private market may be denied
voting rights with respect to the acquired shares, unless a majority of the disinterested shareholders of the corporation elects
to restore such voting rights in whole or in part. The control share acquisition act provides that a person or entity acquires
 &ldquo;control shares&rdquo; whenever it acquires shares that, but for the operation of the control share acquisition act, would
bring its voting power within any of the following three ranges: 20 to 33-1/3%; 33-1/3 to 50%; or more than 50%.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">A &ldquo;control share acquisition&rdquo;
is generally defined as the direct or indirect acquisition of either ownership or voting power associated with issued and outstanding
control shares. The shareholders or Board of Directors of a corporation may elect to exempt the stock of the corporation from the
provisions of the control share acquisition act through adoption of a provision to that effect in the articles of incorporation
or bylaws of the corporation. Our articles of incorporation and bylaws do not exempt our common stock from the control share acquisition
act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The control share acquisition act is applicable
only to shares of &ldquo;Issuing Corporations&rdquo; as defined by the Nevada law. An Issuing Corporation is a Nevada corporation
which (i) has 200 or more shareholders, with at least 100 of such shareholders being both shareholders of record and residents
of Nevada, and (ii) does business in Nevada directly or through an affiliated corporation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">At this time, we do not believe we have
100 shareholders of record resident of Nevada and we do not conduct business in Nevada directly. Therefore, the provisions of the
control share acquisition act are believed not to apply to acquisitions of our shares and will not until such time as these requirements
have been met. At such time as they may apply, the provisions of the control share acquisition act may discourage companies or
persons interested in acquiring a significant interest in or control of us, regardless of whether such acquisition may be in the
interest of our shareholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Nevada &ldquo;Combination with Interested
Stockholders Statute&rdquo; may also have an effect of delaying or making it more difficult to effect a change in control of us.
This statute prevents an &ldquo;interested stockholder&rdquo; and a resident domestic Nevada corporation from entering into a &ldquo;combination,&rdquo;
unless certain conditions are met. The statute defines &ldquo;combination&rdquo; to include any merger or consolidation with an
 &ldquo;interested stockholder,&rdquo; or any sale, lease, exchange, mortgage, pledge, transfer or other disposition, in one transaction
or a series of transactions with an &ldquo;interested stockholder&rdquo; having (i) an aggregate market value equal to 5% or more
of the aggregate market value of the assets of the corporation, (ii) an aggregate market value equal to 5% or more of the aggregate
market value of all outstanding shares of the corporation, or (iii) representing 10% or more of the earning power or net income
of the corporation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">An &ldquo;interested stockholder&rdquo;
means the beneficial owner of 10% or more of the voting shares of a resident domestic corporation, or an affiliate or associate
thereof. A corporation affected by the statute may not engage in a &ldquo;combination&rdquo; within three years after the interested
stockholder acquires its shares unless the combination or purchase is approved by the Board of Directors before the interested
stockholder acquired such shares. If approval is not obtained, then after the expiration of the three-year period, the business
combination may be consummated with the approval of the Board of Directors or a majority of the voting power held by disinterested
stockholders, or if the consideration to be paid by the interested stockholder is at least equal to the highest of (i) the highest
price per share paid by the interested stockholder within the three years immediately preceding the date of the announcement of
the combination or in the transaction in which he became an interested stockholder, whichever is higher, (ii) the market value
per common share on the date of announcement of the combination or the date the interested stockholder acquired the shares, whichever
is higher, or (iii) if higher for the holders of preferred stock, the highest liquidation value of the preferred stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Articles of Incorporation and Bylaws</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">Our articles of incorporation are silent
as to cumulative voting rights in the election of our directors. Nevada law requires the existence of cumulative voting rights
to be provided for by a corporation's articles of incorporation.&nbsp;&nbsp;In the event that a few stockholders end up owning
a significant portion of our issued and outstanding common stock, the lack of cumulative voting would make it more difficult for
other stockholders to replace our Board of Directors or for a third party to obtain control of us by replacing our Board of Directors.
Our articles of incorporation and bylaws do not contain any explicit provisions that would have an effect of delaying, deferring
or preventing a change in control of us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Certificate of Designation for each
of the our Series A Preferred Shares and our Series B Preferred Shares requires that until (i) the liquidation value of the Preferred
Shares is less than $1,000,000 or (ii) the Forced Conversion Conditions have been met, we must obtain the affirmative vote of the
holders of the Preferred Shares prior to the issuance or transfer of more than 25% of our voting control in a single transaction
or series of related transaction.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Transfer Agent and Registrar</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The transfer agent and registrar for our
common stock <FONT STYLE="background-color: white">is VStock Transfer, LLC, 18 Lafayette Place, Woodmere, NY 11598, Phone: (212)
828-8436.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Listing</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The shares of our common stock are quoted
on the OTCQB under the symbol QBIO. On April 17, 2020, the last reported sale price per share for our common stock on the OTCQB
as reported was $2.07.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: white"><B><A NAME="A7"></A>THE PURCHASE
AGREEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">The selling stockholder under this
prospectus is offering for resale up to 5,000,000 shares of our common stock, of which 1,836,286 are Series A Preferred Conversion
shares and 3,163,714 are Series B Conversion Shares. On April 6, 2020, we entered into the Purchase Agreement with the selling
stockholder. Pursuant to the Purchase Agreement, the selling stockholder purchased from us 176,566 Series A Preferred Shares and
503,134 Series A Preferred Shares. Simultaneous with entry into the Purchase Agreement, we entered into a registration rights agreement
with the selling stockholder (the &ldquo;Registration Rights Agreement&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Issuances of the
Preferred Shares and the Conversion Shares will not affect the rights or privileges of our existing stockholders, except that the
liquidation rights of the common stock will be subordinated to the Preferred Shares and the economic and voting interests of each
of our existing stockholders will be diluted as a result of the issuance of the Conversion Shares. Although the number of shares
of Common Stock that our existing stockholders own will not decrease, the shares owned by our existing stockholders will represent
a smaller percentage of our total outstanding shares upon the issuance of any Conversion Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: white"><A NAME="A8"></A><B>SELLING STOCKHOLDER</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><B>Material Relationships</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">The shares of
common stock being offered by the selling stockholder are a portion of the Conversion Shares. We are registering the shares of
common stock in order to permit the selling stockholder to offer the shares for resale from time to time.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">The selling stockholder
has not had a material relationship with us within the past three years except for the entry into the Purchase Agreement and the
Registration Rights Agreement and as noted below:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify"><FONT STYLE="background-color: white">In November 2016, we entered into a convertible debenture
purchase agreement, as amended in March 2017 and October 2017, pursuant to which we sold $4.0 million of convertible debentures
to such selling stockholder between November 2016 and April 2017. Subsequent to their issuance, </FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 45pt"></TD><TD STYLE="width: 27pt"><FONT STYLE="background-color: white">(i)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="background-color: white">the selling stockholder exchanged an aggregate of </FONT>$0.5
million in principal and accrued interest for 162,000 units in an August 2017 private placement. Each unit consisted of one common
stock and one warrant exercisable for five years from the date of date of issuance into a share of our common stock at an exercise
price of $4.50; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -27pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -27pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -27pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 45pt"></TD><TD STYLE="width: 27pt">(ii)</TD><TD STYLE="text-align: justify">we amended the Debentures in October 2017 to extend the maturity date from November 30, 2017 to
November 30, 2018 and issued 25,641 restricted shares of our common stock to the holder of the Debentures as consideration for
the extension.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; background-color: white"><FONT STYLE="background-color: white">Apart
from the $0.5 million of these debentures exchanged for units in August 2017, all of these convertible debentures were converted
into shares of our common stock;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; background-color: white">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify"><FONT STYLE="background-color: white">In January 2018, an affiliate of the selling shareholder
purchased 156,250 shares of common stock together with 156,250 warrants to purchase shares of our common stock combined offering
price of $3.20 per share and warrant. This purchase was part of a larger </FONT>$5.5 million registered direct offering.&nbsp;&nbsp;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify"><FONT STYLE="background-color: white">We entered into a securities purchase agreement with the
selling stock holder in September 2018 and as amended in September 2019 pursuant to which we sold $4.0 million of convertible debentures
to such selling stockholder T</FONT>he conversion price of the convertible debentures was the lower of&nbsp;<FONT STYLE="background-color: white">(i)
$1.00, (ii) 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately preceding the
conversion date, provided that as long as we are not in default under the&nbsp;</FONT>convertible debentures<FONT STYLE="background-color: white">,
the conversion price may never be less than $0.50, or (</FONT>iii) a price agreed to by us and the investor. Additionally, the
maturity date of the convertible debentures was extended to September 21, 2020. Of the convertible debentures sold in this placement,
$3,519,000 of principal and interest were converted into shares of common stock and $766,000 were exchanged for Preferred Shares.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">On October 11, 2019, we entered into a securities purchase agreement with the selling stockholder,
pursuant to which we sold $500,000 of convertible debentures. The debentures bear interest at the rate of 5.5% per annum. The debentures
are convertible at any time on or prior to maturity at the lower of $1.00 or 93% of the average of the four lowest daily VWAPs
during the 10 consecutive trading days immediately preceding the conversion date, provided that the conversion price could never
be less than $0.50, <FONT STYLE="background-color: white">or (</FONT>iii) a price agreed to by us and the investor.&nbsp; As of
April 17, 2020, $500,000 of principal and $14,315.07 of accrued and unpaid interest remaining outstanding on these debentures.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">On December 6, 2019, we entered into a securities purchase agreement with the selling stockholder,
pursuant to which we sold $2,000,000 of convertible debentures. The debentures bore interest at the rate of 5.5% per annum. The
debentures were convertible at any time on or prior to maturity at the lower of $3.00 or 93% of the average of the four lowest
daily VWAPs during the 10 consecutive trading days immediately preceding the conversion date, provided that the conversion price
could never be less than $2.00.&nbsp; Of the convertible debentures sold in this placement, none of principal and interest were
converted into shares of common stock and $2,031,342 were exchanged for Preferred Shares.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; background-color: white"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">On March 31, 2020, we entered into an agreement with the selling stockholder to amend the debentures
that we issued to the selling stockholder in 2018, 2019 and 2020 (the &ldquo;Debentures&rdquo;). Pursuant to the terms of the Debentures,
we could not convert any portion of the Debentures or interest thereon that would result in the holder of the Debentures beneficially
owning more than 4.99% of our common stock. In the amendment letter, we mutually agreed with the holder of the Debentures to increase
that limit from 4.99% to 9.99%.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Beneficial Ownership</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The table below lists the selling stockholder
and other information regarding the beneficial ownership (as determined under Section 13(d) of the Securities Exchange Act of 1934,
as amended, and the rules and regulations thereunder) of the shares of common stock held by the selling stockholder. The second
column lists the number of shares of common stock beneficially owned by the selling stockholder as of April 17, 2020, assuming
conversion of the Series A Preferred Shares at the conversion price of $1.00 and conversion of the Series B Preferred Shares at
the conversion floor price of $0.35 but not taking account of any limitations on conversion and exercise set forth therein or any
dividends accrued but not paid thereon.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The third column lists the shares of common
stock being offered by this prospectus by the selling stockholder and does not take in account any limitations on conversion of
the Preferred Shares set forth therein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The fourth and sixth columns assume the
sale of all of the shares offered by the selling stockholder pursuant to this prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Under the terms of the Series A Preferred
Shares and the Series B Preferred Shares, the selling stockholder may not convert the Series A Preferred Shares or the Series B
Preferred Shares to the extent (but only to the extent) such selling stockholder or any of its affiliates would beneficially own
a number of shares of our common stock which would exceed 9.99%. The number of shares in the second column do not reflect these
limitations and, as a result, differ from the beneficial ownership information set out elsewhere in this Prospectus. The selling
stockholder may sell all, some or none of their shares in this offering.&nbsp;&nbsp;See &ldquo;Plan of Distribution&rdquo;.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">Name of Selling<BR> Stockholder</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">Number of<BR> Shares of<BR> Common Stock<BR> Owned Prior to<BR> Offering (1)</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">Maximum<BR> Number of<BR> Shares of<BR> Common Stock<BR> to be Sold<BR> Pursuant to this<BR> Prospectus</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">Number of<BR> Shares of<BR> Common Stock<BR> Owned After<BR> Offering (2)</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">Number of<BR> Shares Which<BR> May Be Sold in<BR> This Offering As<BR> A Percentage of<BR> Currently<BR> Outstanding<BR> Shares (3)</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Percentage of<BR> Shares of Common Stock<BR> Owned After the<BR> Offering (2)(4)</B></P></TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 30%; font-size: 10pt; text-align: left">YA II PN, LTD.(5)</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: center">19,359,145</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: center">5,000,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: center">14,359,145</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: center">22.3%</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left"></TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: center">52.3%</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left"></TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD STYLE="width: 97%; text-align: justify"><FONT STYLE="font-size: 10pt">Includes (i) 1,871,348 shares of common stock currently held, (ii) 1,765,660 shares of common stock underlying the Series A Preferred Shares beneficially held by such selling stockholder if converted at $1.00, (iii) 14,375,257 shares of common stock underlying the Series B Preferred Shares beneficially held by such selling stockholder if converted at their floor of $0.35, (iv) 318,250 shares of common stock underlying warrants and (v) 1,028,630 shares of common stock underlying outstanding convertible debentures if converted at their floor of $0.50. The amounts reported include common stock that, due to contractual restrictions and the certificates of designation for the Preferred Shares, may not be convertible or exercisable if such conversion would result in the selling stockholder beneficial owning more than 9.99% of the then outstanding shares of common stock.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Represents the difference between columns two and three and includes securities that, due to contractual restrictions and the certificates of designation for the Preferred Shares, may not be convertible or exercisable if such conversion or exercise would result in the selling stockholder beneficial owning more than 9.99% of the then outstanding shares of common stock.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">(3)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">If all of the shares are sold pursuant to this offering and the total number of our issued and outstanding common shares otherwise remains unchanged, such shares sold in this offering shall equal approximately 18.2% of the then issued outstanding shares of our common stock.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">(4)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Assumes that the total number of our issued and outstanding common shares remains unchanged except for the issuance of the shares being sold pursuant to this prospectus.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">(5)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Yorkville Advisors Global, LP (&quot;Yorkville LP&quot;) is YA&rsquo;s investment manager and Yorkville Advisors Global II, LLC (&quot;Yorkville LLC&quot;) is the General Partner of Yorkville LP. All investment decisions for YA are made by Yorkville LLC's President and Managing Member, Mr. Matthew Beckman. The address of YA is 1012 Springfield Avenue, Mountainside, NJ 07092, Attention: Matthew Beckman.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">As of April 17, 2020, our non-affiliates held 19,407,624 shares
of our Common Stock. The shares being offered by the selling stockholder in this prospectus represent approximately 25.8% of our
shares of common stock held by non-affiliates as of April 17, 2020.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Additional Selling Stockholder Information</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 86%; font-size: 10pt; text-align: left">Number of Shares outstanding prior to the initial issuance of Preferred Shares held by persons other than the Selling Stockholder, affiliates of the Company, and affiliates of the Selling Stockholder</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">17,566,276</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Number of Shares registered for resale by the Selling Stockholder or affiliates of the Selling Stockholder in prior registration statements (1)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4,411,500</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Number of Shares registered for resale by the Selling Stockholder or affiliates of the Selling Stockholder that continue to be held by the Selling Stockholder or affiliates of the Selling Stockholder (2)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">318,250</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Number of Shares that have been sold in registered resale transactions by the Selling Stockholder or affiliates of the Selling Stockholder</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,040,727</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Number of Shares registered for resale on behalf of the Selling Stockholder or affiliates of the Selling Stockholder in the current transaction</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5,000,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(1)</TD><TD STYLE="text-align: justify">Consists of 2,000,000 shares in a registration declared effective in December 2018, 312,500 shares
included in a registration declared effective in January 2018, 324,000 shares included in a registration statement declared effective
in September 2017 and 1,775,000 shares in a registration statement declared effective in April 2016.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(2)</TD><TD STYLE="text-align: justify">Represents 162,000 shares of common stock underlying warrants issued in July 2017 and 156,250 shares
of common stock underlying warrants issued in January 2018.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Potential Profits to Selling Stockholder&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The possible profit to the selling shareholder
as a result of the conversion discount depends upon the trading history of our common stock at the time of conversion. If the Preferred
Shares had been converted on the date of their issuance, the profits that the selling stockholder would have realized as a result
of the conversion discount for the shares of common stock underlying the Preferred Shares would have been $3,659,225.&nbsp; The
selling stockholder&rsquo;s profit as a result of the conversion discount may be greater than or less than that amount.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Series A Preferred Shares are exercisable
at a fixed conversion price of $1.00. We note that all of the Series A Preferred Shares were exchanged for outstanding convertible
debentures that were exercisable for $1.00 (their maximum conversion price under any circumstances) on the date of exchange. As
a result, we do not believe that the potential profit as calculated below for those Series A Preferred Shares is different from
the amounts that the holder of the convertible debentures would have received on the date of the issuance of the Series A Preferred
Shares if they had converted the convertible notes on those dates. For the purposes of this table, we have used the date of sale
for each tranche of Series A Preferred Shares as the conversion date of such Series A Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Series B Preferred Shares are convertible
at a conversion price, depending on the public market for our common stock, between $2.70 and $0.35. As we cannot know what the
conversion price will be for the Series B Preferred Shares, for the purposes of this table, we have used the date of sale for each
tranche of Series B Preferred Shares as the conversion date of such Series B Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center">176,566 <BR>
Series A <BR>
Preferred Shares <BR>
Issued on <BR>
April 7, 2020</TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center">303,134 <BR>
Series B <BR>
Preferred Shares <BR>
Issued on <BR>
April 7, 2020</TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center">200,000 <BR>
Series B <BR>
Preferred Shares <BR>
Issued on <BR>
April 17, 2020</TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 58%; font: 10pt Times New Roman, Times, Serif; text-align: justify">Closing market price per share of the underlying securities on date of issuance</TD><TD STYLE="width: 2%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="width: 10%; font: 10pt Times New Roman, Times, Serif; text-align: right">2.12</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="width: 10%; font: 10pt Times New Roman, Times, Serif; text-align: right">2.12</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="width: 10%; font: 10pt Times New Roman, Times, Serif; text-align: right">2.07</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify">Conversion price per share securities on date of issuance</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.00</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.4102</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.9203</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify">Total possible shares to be received in connection with the conversion of the securities at such conversion price</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,765,660</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2,149,582</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,041,504</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify">Combined market price of the total number of underlying shares</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3,743,199</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">4,557,113</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2,155,913</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify">Total possible shares to be received and the combined conversion price of the total number of shares</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,765,660</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3,031,340</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2,000,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify">Total possible discount to the market price as of the date of sale of the Preferred Shares</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.12</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0.1984</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0.1497</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify">Total possible profit that could be realized as a result of the conversion discount as of the date of sale of the Preferred Shares</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,977,539</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,525,773</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">155,913</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: center"><B></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: center"><A NAME="A9"></A><B>BUSINESS&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We are a commercial stage biotechnology
acceleration and development company focused on acquiring and in-licensing pre-clinical, clinical-stage and approved life sciences
therapeutic products. Currently, we have a portfolio of five therapeutic products, including two FDA approved radiopharmaceuticals
for metastatic cancer bone pain (Strontium-89 and Metastron<SUP>TM</SUP>) and three development stage products: QBM-001 for rare
pediatric non-verbal autism spectrum disorder, Uttroside-B for liver cancer, and MAN 01 for glaucoma. Our licensed MAN platform
has several potential therapeutics in development in various indications, including vascular and infectious diseases. The infectious
diseases we may ultimately treat include influenza, Coronavirus, Ebola and others. We aim to maximize risk-adjusted returns by
focusing on multiple assets throughout the discovery and development cycle. We expect to benefit from early positioning in illiquid
and/or less well known privately-held assets, thereby enabling us to capitalize on valuation growth as these assets move forward
in their development.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our mission is to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(i)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">license and acquire pre-commercial
innovative life sciences assets in different stages of development and therapeutic areas from academia or small private companies;</FONT></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0in; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(ii)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">license and acquire FDA
approved drugs and medical devices with limited current and commercial activity; and</FONT></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0in; text-align: justify"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(iii)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">accelerate and advance
our assets to the next value inflection point by providing strategic capital, business development and financial advice and experienced
sector specific advisors.</FONT></TD>
</TR></TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In 2020, we plan to generate revenue from
our Metastron and Strontium-89 products for pain palliation in bone metastases as well as explore commencing a therapeutic expansion
post-marketing phase 4 trial for Strontium-89. We also intend to file investigational new drug applications, or INDs late in 2020
or early 2021, with the FDA for each of our Uttroside-B and MAN 01 assets for the treatment of liver cancer and glaucoma, respectively.
We also intend to advance our QBM-001 asset to address a non-verbal learning disorder in autistic children.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Following is a summary of our product pipeline.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Our Strategy</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our goal is to become a leading biotechnology
acceleration and development company with a diversified portfolio of therapeutic products commercially available and in development.
To achieve this goal, we are executing on the following strategy:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><B><I>&#9679;</I></B></TD><TD STYLE="text-align: justify"><B><I>Strategically collaborate or in- and out-license
select programs.</I></B></TD>
</TR></TABLE>

<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt 0pt 0.5in">We seek to collaborate or in- and out-license certain potentially
therapeutic candidate products to biotechnology or pharmaceutical companies for preclinical and clinical development and commercialization.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 68.75pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><B><I>&#9679;</I></B></TD><TD STYLE="text-align: justify"><B><I>Highly leverage external talent and resources.</I></B></TD>
</TR></TABLE>

<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt 0pt 0.5in">We plan to maintain and further build our team which is
skilled in evaluating technologies for development and product development towards commercialization. By partnering with industry
specific experts, we are able to identify undervalued assets that we can fund and assist in enhancing inherent value. We plan to
continue to rely on the extensive experience of our management team to execute on our objectives.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 68.75pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 68.75pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 68.75pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><B><I>&#9679;</I></B></TD><TD STYLE="text-align: justify"><B><I>Evaluate commercialization and monetization strategies
on a product-by-product basis in order to maximize the value of our product candidates or future potential products.</I></B></TD>
</TR></TABLE>

<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt 0pt 0.5in">As we move our drug candidates through development toward
regulatory approval, we will evaluate several options for each drug candidate&rsquo;s commercialization or monetization strategy.
These options include building our own internal sales force; entering into a joint marketing partnership with another pharmaceutical
or biotechnology company, whereby we jointly sell and market the product; and out-licensing any product that we develop by ourselves
or jointly with another party, whereby another pharmaceutical or biotechnology company sells and markets such product and pays
us a royalty on sales. Our decision will be made separately for each product and will be based on a number of factors including
capital necessary to execute on each option, size of the market to be addressed and terms of potential offers from other pharmaceutical
and biotechnology companies. It is too early for us to know which of these options we will pursue for our drug candidates, assuming
their successful development.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 68.75pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><B><I>&#9679;</I></B></TD><TD STYLE="text-align: justify"><B><I>Acquire commercially or near-commercially ready
products and build out the current market for such.</I></B></TD>
</TR></TABLE>

<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt 0pt 0.5in">In addition to acquiring pre-clinical products, in assembling
a diversified portfolio of healthcare assets, we plan on acquiring assets that are either FDA approved or are reasonably expected
to be FDA approved within 12 months of our acquiring them. We anticipate hiring a contract sales organization to assume the bulk
of the sales and distribution efforts related to any such product.&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>General Information</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We were incorporated in the State of Nevada
on November 22, 2013 under the name ISMO Technology Solutions. On August 5, 2015, we recorded a stock-split effectuated in the
form a stock dividend.&nbsp;The stock dividend was paid at a rate of 1.5 &ldquo;new&rdquo; shares for every one issued and outstanding
share held. On June 1, 2015, our Board of Directors determined it was in the best interest of the Company to establish a base of
operations in the biomedical industry.&nbsp;As a result, the Board of Directors approved a change in the Company&rsquo;s name from
 &ldquo;ISMO Tech Solutions, Inc.&rdquo; to &ldquo;Q BioMed Inc.&rdquo;&nbsp; Q BioMed Inc. established its business as a biomedical
acceleration and development company focused on licensing, acquiring and providing strategic resources to life sciences and healthcare
companies.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On October 27, 2015, we filed a Certificate
of Amendment to our Articles of Incorporation with the Secretary of State of Nevada to increase the number of shares of common
stock that we are authorized to issue from 100,000,000 shares to 250,000,000 shares.&nbsp;The Certificate of Amendment affected
no provisions of our Articles of Incorporation other than the number of common stock that we are authorized to issue, and we are
still authorized to issue 100,000,000 shares of preferred stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Our Drug Discovery Approach</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We aim to acquire, or license and have
assembled, a pipeline of multiple therapeutics in development stages ranging from early pre-clinical to commercial ready. Our model
seeks to diversify risk by broadening the therapeutic areas we work in as well as providing multiple catalysts as we advance assets
through the clinical and regulatory process.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our mission is to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 3%; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 4%; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(i)</FONT></TD>
    <TD STYLE="width: 93%; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">license and acquire pre-commercial innovative life sciences assets in different stages of development and therapeutic areas from academia or small private companies;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(ii)</FONT></TD>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">license and acquire FDA approved drugs and medical devices with limited current and commercial activity; and</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: -16.5pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(iii)</FONT></TD>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">accelerate and advance our assets to the next value inflection point by providing: (A) strategic capital, (B) business development and financial advice and (C) experienced sector specific advisors.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Our Research and Development Activities</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As a biomedical acceleration and development
company, research and development is a core aspect of our business. In the fiscal years ended November 30, 2019 and 2018, we have
incurred approximately $3.5 million and $3.2 million, respectively, on research and development activities, and in the three months
ended February 29, 2020 we incurred approximately $0.3 million on such activities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Metastron&trade; and Strontium-89 Chloride
USP Injection</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">We have been working hard to commercialize
Strontium-89 for the non-opiate treatment of metastatic cancer bone pain.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">On November 14, 2019, the Department
of Health and Human Services notified us that our supplemental abbreviated new drug application for a new drug product manufacturing
site, IsoTherapeutics Group, LLC, has been approved. IsoTherapeutics is now cleared to manufacture our FDA approved non-opioid
cancer bone pain drug Strontium-89 Chloride USP.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">On February 13th we announced the launch
of our FDA approved non-opioid drug Strontium-89 (Strontium Chloride Sr-89 Injection, USP) which has been shown to relieve the
persistent pain associated with cancer that has metastasized to bone. In several multicenter, placebo-controlled trials in cancer
patients with persistent pain after external beam radiation therapy for bone metastases, pain relief occurred in more patients
treated with a single injection of Strontium-89 than in patients treated with an injection of placebo*, with a greater percentage
of patients experiencing pain scores of zero with no use of rescue opioid analgesics. Median duration of pain palliation has been
shown to be 2 to 5 months. Strontium-89 can be redosed every 90 days.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">An estimated 10 million people are
living with this condition, and due to the opioid crisis, doctors and patients are looking for an alternative to treat metastatic
cancer associated bone pain. Given that Strontium-89 can be administered every three months and proven effective in approximately
80% of the patients who received the drug, Q BioMed is hopeful that broad market reacceptance will be swift.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">We have already received enquiries
and orders from clinics and hospitals around the world. Through our US distribution partner, Jubilant RadiopharmaTM, we have the
capability to reach patients in all 50 states. Our contract manufacturing facility, which is FDA approved to manufacture Strontium-89,
is manufacturing initial commercial-scale quantities, with the first lot produced and shipped in February 2020. The first patient
was dosed in early March, and recent feedback has been that they have had positive results that affirm the outcomes expected from
our clinical data. We look forward to having many more patients benefit from the pain relief that Strontium89 can provide. Manufacturing
will reach full production quantities in April, if no major interruptions occur due to COVID-19 restrictions on people or supply
chain, materials, patients should start to receive treatment from April onwards. Commercial and marketing activities, including
conferences (post COVID-19 restrictions) and sales, will commence concurrent with commercial availability. Strontium89 is reimbursed
by Medicare and most insurance companies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">This is a major milestone for Q BioMed.
We are now a revenue generating entity. We look forward to being able to help serve the unmet needs of the millions of patients
suffering from debilitating pain associated with metastatic cancer in the bone. Years of well documented data prove that Strontium89
benefits this patient population. We believe this drug has a very important role to play as clinicians move toward proven non-opioid
therapeutics for pain palliation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">We plan to launch the drug in global
markets including Europe in 2020 and we have already seen interest from this region. This year Q BioMed will also plan to undertake
further research for Strontium89 for potential label extension into therapeutic use for survival benefit in metastatic bone cancer
through a Phase IV study as well as explore combination studies for enhancing the value proposition of the drug through better
outcomes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">Our leadership team has been expanded
with the addition of a Chief Commercial Officer as well as a Global Head of Regulatory Affairs who will focus on international
regulatory access to markets beyond the US. We have proactively on-boarded our commercial team tasked with infrastructure set-up,
including: medical information and pharmacovigilance, government contracting, marketing, contract sales and telesales. We have
announced a distribution partnership with Jubilant Radiopharma who have all the capabilities we require to access the US market,
including warehousing/inventory management, invoicing and customer service/ordering. Jubilant also has a sales team that calls
on major providers, a national network of nuclear pharmacies in the U.S. and distribution and coverage throughout the U.S.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The global demand for access to generic
drugs and non-opioid therapies has given Q BioMed access to a global market much sooner than expected and we continue to be extremely
excited about its prospects to re-establish a deserved niche in the late stage cancer treatment landscape.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Mannin Intellectual Property</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On October 29, 2015, we entered into a
Patent and Technology License and Purchase Option Agreement, as amended in April 2019, with Mannin whereby we were granted a worldwide,
exclusive license on, and option to acquire, certain Mannin intellectual property, or IP, within a four-year term.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Mannin IP is initially focused on developing
a first-in-class eye drop treatment for glaucoma. The technology platform may be expanded in scope beyond ophthalmological uses
and may include cystic kidney disease,&nbsp;cardiovascular diseases and infectious disease. This platform technology has application
in many disease states that result in &lsquo;leaky&rsquo; vessels and the inefficient flow of fluids, like the recent Coronavirus
outbreak. Pursuant to the exclusive license from Mannin, we may purchase the Mannin IP within six years of entry into the agreement
in exchange for investing a minimum of $4,000,000 into the development of the Mannin IP. During the years ended November 30,&nbsp;2019
and 2018, we respectively incurred approximately $2.1 million and $2.1 million of research and development expenses under the Exclusive
License. The purchase price for the Mannin IP is $30,000,000 less the amount of cash paid by us for development and the value of
the common stock issued to the vendor. We can make this all or part of this payment in stock, provided that such stock does not
represent 15% or more of our issued and outstanding common stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In the event that: (i) we do not exercise
the option to purchase the Mannin IP; (ii) we fail to invest the $4,000,000 within six years from the date of the exclusive license;
or (iii) we fail to make a diligent, good faith and commercially reasonable effort to progress the Mannin IP, all Mannin IP shall
revert back to Mannin and we shall be granted the right to collect twice the monies invested through that date of reversion by
way of a royalty along with other consideration which may be perpetual.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On March 26, 2019, we extended the option
period of the initial agreement that was entered into on October 29, 2015. The extension period was extended to October 29, 2021
and 100,000 shares was issued in exchange for the extension.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><I>MAN-01 and GDF15</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">There are over 60 million patients
worldwide with Primary Open-Angle Glaucoma. MAN-01 aims to reduce the pressure build-up in the eye by assisting with, and correcting,
drainage problems in tiny vessels in the eye called the Schlemm&rsquo;s Canal. MAN-01 is being designed to target these unique
and extremely important vessels, as over 70% of all fluid in the eye flows through the Schlemm&rsquo;s Canal. Currently, the MAN-01
program is finalizing its preclinical lead candidate optimization by completing a series of ophthalmic in vivo studies to demonstrate
efficacy. After successful completion of the in vivo studies, Mannin Research will begin preparing for preclinical toxicology and
filing of its IND. Our research shows that the drug&rsquo;s mechanism of action may ameliorate vessel damage in several other diseases
such as: kidney disease, cardiovascular disease, and against infectious diseases, such as influenza and the current corona virus
outbreak. We believe these programs comprise a multi-disease platform technology that has several valuable applications. Adding
the GDF15 biomarker to our portfolio is a significant step to securing a unique product offering that put precision medicine and
patient specific treatment in the hands of clinicians. GDF15 is a companion diagnostic marker to the MAN-01 drug for determining
the severity of glaucoma using the expression levels of Growth Differentiation Factor 15 (GDF15). Determining the severity of glaucoma
using this biomarker will aid in treatment decisions for patients diagnosed with, and being treated for, glaucoma. Recent buyouts
in the Biotechnology space has us believing that large pharma companies could be looking for valuable assets like this with multiple
downlines because of expiring patient protection on current drugs. Our collaborators at the Washington University in St. Louis
are currently examining the effectiveness of GDF15 as a clinical biomarker in a clinical trial. In parallel, Q BioMed and Mannin
Research are working with the Biointerfaces Institute at McMaster University in Ontario, Canada to develop a GDF15 biomarker diagnostic
kit for monitoring glaucoma severity and progression. The aim is to develop a simple integrated diagnostic test that can be performed
at a physician&rsquo;s office with no external, expensive equipment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><I>The MAN Platform for other indications:</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">Mannin presented positive data on a
potential new treatment for acute kidney injury (AKI) at the American Society of Nephrology&rsquo;s annual meeting held on November
7, 2019 in Washington DC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">The data presented demonstrates the
Ang-Tie2 signaling pathway as a promising therapeutic target for renal protection from acute kidney injury following ischemic reperfusion.
Ischemia&ndash;reperfusion (IR) injury to the kidney occurs in a range of clinically important scenarios including hypotension,
sepsis and in surgical procedures such as cardiac bypass surgery and kidney transplantation, leading to AKI. In-hospital mortality
for patients with AKI has recently been estimated to be between 20 and 25% and mortality rates in excess of 50% have been reported
in critically ill patients with AKI requiring dialysis. For those patients who survive, complications include chronic kidney disease
(CKD) and end-stage renal disease (ESRD); cardiovascular events, and reduced quality of life. In the United States, AKI is associated
with an increase in hospitalization costs that range from $5.4 to $24.0 billion. No effective treatments have been approved by
the FDA. This represents a very significant opportunity to advance a therapeutic in an underserved patient population.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">Mannin is developing new therapeutics
to treat a variety of vascular diseases, including the new coronavirus which originated in Wuhan, China, with a rapidly rising
number of deaths and confirmed cases. The Coronavirus has been declared a Global Health Emergency by the World Health Organization
(WHO).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">While Mannin is not developing a vaccine
against infectious diseases, it is hoping to develop a new drug which would increase the survival rate of patients by reducing
the severity of disease through enhancement of host-directed therapeutic response.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">Mannin recently submitted a grant application
to the U.S. National Institutes of Health for Small Business Technology Transfer Grant Applications for approximately US $0.2 million
for the MAN-11 biologic. The studies will be conducted at Northwestern University to investigate treatment of vascular leakage
to treat sepsis and other infectious diseases. Mannin has also been working with Canada&rsquo;s National Research Council (NRC.CNRC)
since December 2019 to support the development of the biologic. In September 2019, the German state of Saxony awarded Mannin an
approximately US $7.7 million grant to advance the Mannin portfolio of vascular diseases, including development of the biologic.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify">While we continue to advance all our
assets, our key focus for both capital expense and time is on the commercialization of Strontium-89 Chloride USP Injection. This
is a near-term revenue generator and we believe a significant catalyst and long-term value driver for us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.2pt 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>ASD-002</B>&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On April 21, 2017, we entered into a License
Agreement on Patent &amp; Know-How Technology with ASDERA whereby we were granted a worldwide, exclusive, license on certain ASDERA
intellectual property, which was previously referred to as ASD-002 in our pipeline, and was intended to treat Disruption of Active
Language Development (DALD) in toddlers developing Autism Spectrum Disorders. Under that agreement, we paid ASDERA $50,000 and
issued 125,000 shares of our common stock. On November 27, 2019, we notified ASDERA that we considered the Agreement to have been
rescinded retroactively as of April 21, 2017.&nbsp;As a result of such rescission, we believe that we have no continuing material
obligations to ASDERA. However, we will continue to develop unique technologies for the benefit of underserved patient populations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">QBM-001</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Among the more than 60,000 US children
who develop autism spectrum disorders, or ASD, every year, approximately 20,000 become nonverbal and will have to rely on assisted
living for the rest of their lives. In parallel to ASD-002, we have been developing a product, QBM-001, intended to treat the rare
condition - pediatric minimally verbal autism. Many of the children who miss this potential treatment window between the age of
2 and 5 years old, may become non-verbal for the rest of their lives. Currently, there is no treatment for this rare disorder.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">QBM-001 is not intended to treat other
ASDs or to be used beyond the specific group and the estimated treatment window. The &ldquo;treatment window&rdquo; results from
independent research that revealed a decreased density in the cortex region of the brain in minimally verbal children with autism,
who were 7 years of age. A biomarker study performed by us has directed us to conclude that QBM-001 cannot be used for other autistic
groups. The study analyzed over 2000 known autistic markers and found two distinct biomarkers for children with pediatric minimally
verbal autism. The biomarkers did not overlap with the high functioning group of autistic children, nor the intermediate group,
which struggles with, but develops limited language. The biomarkers gave us insight into what was wrong with the children and has
given us unique insight on how to ameliorate their condition with the goal of helping them develop the ability to speak.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The biomarker study also led us to evaluate
and identify a rat model that contains the biomarkers and is thus a good model to test QBM-001. In addition, we have access to
cell lines from deceased children who had pediatric minimally verbal autism. QBM-001 consists of a combination of products that
target different mechanisms of action. Having the cell lines and rat model available to us provides us with an excellent preclinical
path to validate the safety and efficacy of QBM-001.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We recently filed an orphan drug application
for our QBM potential drug candidate and plan on filing an IND QBM-001 in 2021.&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>QBM-001 - Addressing Rare Pediatric
Minimally Verbal Autism</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Causes of non-verbal learning disorder
have been linked to several complications that range from a specific mutated gene as with Fragile X Syndrome, Rett Syndrome, Phelan
McDermid Syndrome or autoimmunity, where the body&rsquo;s immune system is attacking parts of the brain. Trauma, microbial infections
and environmental factors have also been linked to non-verbal learning disorder. Ongoing research is helping to further explain
the root cause of why children become non-verbal or minimally verbal.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Cognitive intervention is the only form
for treatment that has shown to help improve speech capability and social interaction in autistic children, however, with minimal
benefit with children with pediatric minimally verbal autism. As intervention does not lead to speech progression, being minimally
verbal carries a lifetime burden of over $5 million per person for cost of care. This is further compounded by additional expenses
during the lifespan of the person due to loss in productivity in addition to severe emotional strain for the child and the parents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As there are no treatment options for these
patients, we believe there is a significant economic opportunity to bring a drug to market in this indication. The active ingredients
in our compound are well known and have been approved by worldwide regulators for many years. Using a novel delivery and formulation
for the ingredients, we intend to advance this drug through the 505(b)2 pathway.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>RGCB and OMRF Intellectual Property</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On June 15, 2017, we entered into a Technology
License Agreement with RGCB and OMRF whereby they granted us a worldwide, exclusive, license on intellectual property related to
Uttroside-B.&nbsp; Uttroside-B is a chemical compound derived from the plant&nbsp;Solanum nigrum Linn, also known as Black Nightshade
or Makoi.&nbsp; We seek to use the Uttroside-B IP to create a&nbsp;chemotherapeutic agent against&nbsp;liver cancer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The initial cost to acquire the exclusive
license for Uttroside was $10,000. In addition to royalties based upon net sales of the product candidate, if any, we are required
to make additional payments upon the following milestones:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&#9679;</TD><TD STYLE="text-align: justify">the completion of certain preclinical studies;</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 44.85pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&#9679;</TD><TD STYLE="text-align: justify">the filing of an investigational new drug application
with the US Food and Drug Administration or the filing of the equivalent application with an equivalent governmental agency;</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 44.85pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&#9679;</TD><TD STYLE="text-align: justify">successful completion of each of Phase I, Phase II
and Phase III clinical trials;</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 44.85pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&#9679;</TD><TD STYLE="text-align: justify">FDA approval of the product candidate;</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 44.85pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 44.85pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 44.85pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&#9679;</TD><TD STYLE="text-align: justify">approval by the foreign equivalent of the FDA of the
product candidate;</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 44.85pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&#9679;</TD><TD STYLE="text-align: justify">achieving certain worldwide net sales; and</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.1pt; text-indent: 44.85pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&#9679;</TD><TD STYLE="text-align: justify">a change of control of our Company.</TD>
</TR></TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Subject to the terms of the exclusive license
for Uttroside, we will be in control of the development and commercialization of the product candidate and are responsible for
the costs of such development and commercialization.&nbsp; We are obligated to undertake a good-faith commitment to (i) fund the
pre-clinical trials and (ii) to initiate a Phase II clinical trial within six years of the date of the Agreement.&nbsp; Failure
to show a good-faith effort to meet those goals would mean that the exclusive license for Uttroside would revert to the licensors.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>UTTROSIDE-B - A Novel Chemotherapeutic
for Liver Cancer</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The liver is the football-sized organ in
the upper right area of the belly. Symptoms of liver cancer are uncommon in the early stages. Liver cancer treatments vary, but
may include removal of part of the liver, liver transplant, chemotherapy, and in some cases radiation. Primary liver cancer (hepatocellular
carcinoma) tends to occur in livers damaged by birth defects, alcohol abuse, or chronic infection with diseases such as hepatitis
B and C, hemochromatosis (a hereditary disease associated with too much iron in the liver), and cirrhosis. In the United States,
the average age at onset of liver cancer is 63 years. Men are more likely to develop liver cancer than women, by a ratio of 2 to
1.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The only currently marketed drug is a tryosine
kinase inhibitor antineoplastic agent, sorafinib. Current sales of sorafinib are estimated at $1 billion per year.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Uttroside-B appears to affect phosphorylated
JNK (pro survival signaling) and capcase activity (apoptosis in liver cancer). It is a natural compound fractionated Saponin derived
from the Solarim Nigrum plant. It is a small molecule that showed in early investigation to increase the cytotoxicity of a variety
of liver cancer cell types and importantly to be up to ten times more potent than Sorafenib in pre-clinical studies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As it is not feasible to use the plant
as the source for a drug, we successfully synthesized the molecule thereby creating an exact replica of the naturally occurring
chemical compound. In a joint research program with India-based Chemveda Life Sciences in 2017, we initiated this very complex
and challenging synthesis program. After 2 years, the exceptional chemists at Chemveda and our scientists, succeeded. The synthetic
molecule has now been tested in comparison to the original plant molecule and the results confirm the same efficacy against the
same liver cancer cell lines. We are now preparing to advance this into the pre-clinical program leading to an IND by the end of
2020 and a proof of concept clinical program in 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note on COVID-19</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">To date, the Covid-19 pandemic has not
materially affected our Strontium89 supply chain or production schedule, although a slight delay in supply chain is probable and
expected. However, the pandemic may present an opportunity for Strontium89. In an effort to reduce Covid-19 transmission to at-risk
populations and lower the burden on healthcare systems, systems and organizations are seeking ways to redirect immunocompromised
patients out of hospital settings and hospital care wherever possible. Cancer patients with bone metastases often receive daily
radiation treatments at the hospital. Additionally, those with advanced bone metastases often present at the ER for skeletal-related
events and breakthrough pain. Strontium89 has been used successfully to treat pain associated with bone metastases for over 30
years. As an injection given only every 90 days with significant efficacy levels and relatively minor side effects, Strontium89
is a solution that fulfills many of the needs uniquely represented by the Covid-19 pandemic. However, we are still assessing the
potential for Strontium89 to fulfill this need and do not yet know what the impact of that effort may be.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">With respect to Covid-19, we are working
on developing a potential treatment. It is early stage but could be an important tool in treating several infectious diseases that
result in respiratory complications. Our technology partner and licensor, Mannin Research has received requests from, and submitted
responses to, governmental organizations worldwide and philanthropic groups for information about the potential use of its biologic
treatment for Covid-19. The potential treatment is based on the understanding that vascular leakage is a key driver of organ injury
in diseases such as Acute Respiratory Distress Syndrome (ARDS) caused by viruses, including Covid-19. The Angiopoietin-Tie2 signaling
pathway for the treatment of vascular permeability associated with pulmonary edema from respiratory infections like Covid -19,
but also ARDS, SARS, seasonal Influenzas and others. There were 45 million symptomatic flu cases, 810,000 hospitalizations and
61,000 deaths &ndash; in the United States alone during the 2017-2018 flu season, according to the CDC. We are in the early stages
of investigations and preclinical evaluation of this potential drug and hope to collaborate with others on a global basis to advance
this program as rapidly as possible. Even if it is ultimately too late to treat this season's Covid-19 outbreak, if effective,
it could be utilized for seasonal influenzas and future similar pandemic viral threats</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Patents and Intellectual Property Rights</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If products we acquired do not have adequate
intellectual protection, we will take the necessary steps to protect our proprietary therapeutic product candidate assets and associated
technologies that are important to our business consisting of seeking and maintaining domestic and international patents. These
may cover our products and compositions, their methods of use and processes for their manufacture and any other inventions that
may be commercially important to the development of our business. We also rely on trade secrets to protect aspects of our business.
Our competitive position depends on our ability to obtain patents on our technologies and our potential products, to defend our
patents, to protect our trade secrets and to operate without infringing valid and enforceable patents or trade secrets of others.
We seek licenses from others as appropriate to enhance or maintain our competitive position.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We hold a license to all intellectual property
related to each of (i) MAN 01, the drug candidate for the treatment of Primary Open Angle Glaucoma and all other potential therapeutics
that may originate from the platform, (ii) QBM-001, the combination drug candidate related to a nonverbal disorder associated with
autism, (iii) SR89, our generic Strontium-89 Chloride product candidate for metastatic cancer bone pain therapy, (iv) Metastron<SUP>TM</SUP>,
our branded Strontium-89 Chloride product candidate for metastatic cancer bone pain therapy and (iv) the&nbsp;Uttroside-B&nbsp;platform.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have applied for some patents in our
own right. Most patents and applications are held in the licensors&rsquo; or inventors&rsquo; names and are assignable under license
agreements to Q BioMed Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Competition</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We operate in highly competitive segments
of the biotechnology and biopharmaceutical markets. We face competition from many different sources, including commercial pharmaceutical
and biotechnology enterprises, academic institutions, government agencies, and private and public research institutions. Our product
candidates, if successfully developed and approved, will compete with established therapies, as well as new treatments that may
be introduced by our competitors. Many of our competitors have significantly greater financial, product development, manufacturing
and marketing resources than us. Large pharmaceutical companies have extensive experience in clinical testing and obtaining regulatory
approval for drugs. In addition, many universities and private and public research institutes are active in the fields in which
we research, some in direct competition with us. We also may compete with these organizations to recruit management, scientists
and clinical development personnel. Smaller or early-stage companies may also prove to be significant competitors, particularly
through collaborative arrangements with large and established companies. New developments, including the development of other biological
and pharmaceutical technologies and methods of treating disease, occur in the pharmaceutical and life sciences industries at a
rapid pace. Developments by competitors may render our product candidates obsolete or noncompetitive. We will also face competition
from these third parties in recruiting and retaining qualified personnel, establishing clinical trial sites and patient registration
for clinical trials and in identifying and in-licensing new product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Raw Materials and Third-Party Manufacturing</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We began commercially producing our sole
product in February 2020, Strontium89. To date, we have sourced all the raw material needed for Strontium89 from Polatom in Poland.
Due to the limited production to date of this product to date, we do not consider it a substantial risk that we have only one supplier
of this raw material. As we ramp up production, we intend to use at least one other supplier of the raw material, but we do not
yet have any such arrangements in place.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Likewise, all of our product has been manufactured
by IsoTherapeutics in Houston, Texas. Although we will continue to rely on them for the manufacture of this product, we do not
currently have any intention of finding an additional manufacturer. Were our relationship with IsoTherapeutics to terminate or
they were otherwise unable to manufacture Strontium89, we would not be able to produce more product until a replacement FDA approved
manufacturer is found.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Government Regulation</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The clinical development, manufacturing,
labeling, storage, record-keeping, advertising, promotion, import, export, marketing and distribution of our product candidates
are subject to extensive regulation by the FDA in the United States and by comparable health authorities in foreign markets. In
the United States, we are not permitted to market our product candidates until we receive approval of a Biologics License Application
(&ldquo;BLA&rdquo;) from the FDA. The process of obtaining BLA approval is expensive, often takes many years and can vary substantially
based upon the type, complexity and novelty of the products involved. In addition to the significant clinical testing requirements,
our ability to obtain marketing approval for these products depends on obtaining the final results of required non-clinical testing,
including characterization of the manufactured components of our product candidates and validation of our manufacturing processes.
The FDA may determine that our product manufacturing processes, testing procedures or facilities (or those of third parties upon
which we rely) are insufficient to justify approval. Approval policies or regulations may change, and the FDA has substantial discretion
in the pharmaceutical approval process, including the ability to delay, limit or deny approval of a product candidate for many
reasons. Despite the time and expense invested in clinical development of product candidates, regulatory approval is never guaranteed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The FDA or another regulatory agency can
delay, limit or deny approval of a product candidate for many reasons, including, but not limited to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 4%; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 1%; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="vertical-align: top; width: 1%; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 94%; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">the FDA or comparable foreign regulatory authorities may disagree with the design or implementation of our clinical trials;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">we may be unable to demonstrate to the satisfaction of the FDA that a product candidate is safe and effective for any indication;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">the FDA may not accept clinical data from trials which are conducted by individual investigators or in countries where the standard of care is potentially different from the United States;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">the results of clinical trials may not meet the level of statistical significance required by the FDA for approval;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">we may be unable to demonstrate that a product candidate&rsquo;s clinical and other benefits outweigh its safety risks;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">the FDA may disagree with our interpretation of data from preclinical studies or clinical trials;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">the FDA may fail to approve our manufacturing processes or facilities or those of third-party manufacturers with which we or our collaborators contract for clinical and commercial supplies; or</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">&#9679;</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 0.1pt; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">the approval policies or regulations of the FDA may significantly change in a manner rendering our clinical data insufficient for approval.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">With respect to foreign markets, approval
procedures vary among countries and, in addition to the aforementioned risks, can involve additional product testing, administrative
review periods and agreements with pricing authorities. In addition, recent events raising questions about the safety of certain
marketed pharmaceuticals may result in increased cautiousness by the FDA and comparable foreign regulatory authorities in reviewing
new pharmaceuticals based on safety, efficacy or other regulatory considerations and may result in significant delays in obtaining
regulatory approvals. Any delay in obtaining, or inability to obtain, applicable regulatory approvals would prevent us from commercializing
our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Costs and Effects of Compliance with
Environmental Laws</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Federal, state, and international environmental
laws may impose certain costs and restrictions on our business. We do not believe that we have yet spent or lost money due to these
laws and regulations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Product Liability and Insurance</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We face an inherent risk of product liability
exposure related to the testing of our product candidates in human clinical trials and the eventual sale and use of any product
candidates, and claims could be brought against us if use or misuse of one of our product candidates causes, or merely appears
to have caused, personal injury or death. While we have and intend to maintain product liability insurance relating to our clinical
trials, our coverage may not be sufficient to cover claims that may be made against us and we may be unable to maintain such insurance.
Any claims against us, regardless of their merit, could severely harm our financial condition, strain our management and other
resources or destroy the prospects for commercialization of the product which is the subject of any such claim. We are unable to
predict if we will be able to obtain or maintain product liability insurance for any products that may be approved for marketing.
Additionally, we have entered into various agreements where we indemnify third parties for certain claims relating to our product
candidates. These indemnification obligations may require us to pay significant sums of money for claims that are covered by these
indemnifications. We have product liability insurance in place at the time of product launch.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Employees</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As of February 29, 2020, we had 1 employee
and 9 management consultants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Properties</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We do not own any properties. We occupy a shared office facility
in Cayman Islands under a license for $30,000 per annum.&nbsp; The agreement under which we have the license expires in December
2022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Legal Proceedings</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We are not a party to any material pending
legal proceeding, arbitration or governmental investigation, and to the best of our knowledge, no such proceedings have been initiated
against us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: white"><A NAME="A10"></A><B>MARKET FOR REGISTRANT&rsquo;S
COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: white"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Market Information</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Our common stock
is listed on the Over the Counter QB (&ldquo;OTCQB&rdquo;) under the symbol &ldquo;QBIO&rdquo;. The market for our common stock
is limited, volatile and sporadic. The following table sets forth, for the periods indicated, the high and low bid prices of our
common stock on the OTCQB as reported by Google Finance. The following quotations reflect inter-dealer prices, without retail mark-up,
markdown, or commissions, and may not reflect actual transactions. Those fiscal quarters during which there were no sales of our
common stock have been labeled as &ldquo;n/a&rdquo;.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">High Bid</TD><TD STYLE="padding-bottom: 1pt; font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Low Bid</TD><TD STYLE="padding-bottom: 1pt; font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">Fiscal Year 2020</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 72%; font: 10pt Times New Roman, Times, Serif; padding-left: 4.5pt">May 31, 2020 (to April 17, 2020)</TD><TD STYLE="width: 2%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="width: 10%; font: 10pt Times New Roman, Times, Serif; text-align: right">3.00</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="width: 10%; font: 10pt Times New Roman, Times, Serif; text-align: right">1.12</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 4.5pt">February 29, 2020</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3.45</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2.41</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Fiscal Year 2019</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-indent: 4.5pt">November 30, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2.38</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0.37</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-indent: 4.5pt">August 31, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.64</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0.91</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-indent: 4.5pt">May 31, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2.29</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.53</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-indent: 4.5pt">February 28, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2.43</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0.95</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Fiscal Year 2018</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;November 30, 2018</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3.37</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.71</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;August 31, 2018</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3.65</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.67</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;May 31, 2018</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3.95</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2.85</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;February 28, 2018</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">5.55</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2.73</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The last reported sales price for our shares
on the OTCQB as of April 17, 2020 was $2.07 per share. As of April 17, 2020, we had approximately 134 shareholders of record at
our Transfer Agent.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Dividend Policy</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have never declared or paid any cash
dividends on our common stock.&nbsp; For the foreseeable future, we will not pay dividends on our common stock but instead we intend
to retain any earnings to finance the development and expansion of our business and do not anticipate paying any cash dividends
on our common stock. The terms of our Preferred Shares prohibit us from declaring any dividends on our common stock without the
affirmative vote of the holders of the Preferred Shares until (i) the liquidation value of the Preferred Shares is less than $1,000,000
or (ii) certain conditions regarding the trading of our common stock have been met. Any future determination to pay dividends will
be at the discretion of the Board of Directors and will depend upon then existing conditions, including our financial condition
and results of operations, capital requirements, contractual restrictions, business prospects and other factors that the board
of directors considers relevant.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our Series A Preferred Shares carry an
annual dividend equal to 8% of the liquidation value of the Series A Preferred Shares, which liquidation value, subject to customary
adjustments, is equal to the per Series A Preferred Share purchase price of $10. As we have sold 176,566 Series A Preferred Shares
to date for gross proceeds of $1,765,660, we will have to pay $141,253 in dividends on the Series A Preferred Shares if all of
such shares remain outstanding on the one-year anniversary of their issuance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our Series B Preferred Shares carry an
annual dividend equal to 8% of the liquidation value of the Series B Preferred Shares, which liquidation value, subject to customary
adjustments, is equal to the per Series B Preferred Share purchase price of $10. As we have sold 503,134 Series B Preferred Shares
to date for gross proceeds of $5,031,340, we will have to pay $402,507 in dividends on the Series B Preferred Shares if all of
such shares remain outstanding on April 6, 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Any dividend due on the Preferred Shares is to be paid in an
amount of common equal to the dollar value of such dividend amount divided by the volume weighted average price (&ldquo;VWAP&rdquo;)
of our common stock on the date of such dividend payment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Securities Authorized For Issuance under Compensation Plans</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">None.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Stock Incentive Plan</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">None.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Warrants and Convertible Securities</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As of April 17, 2020, we had&nbsp;granted
warrants exercisable into 9,785,000 shares of common stock, granted options (not all of which had vested) exercisable into 1,350,000
shares of common stock, issued outstanding notes convertible into a maximum of approximately, 1,250,000 shares of common stock
(assuming conversion at the floor price of the respective notes)&nbsp;&nbsp;, issued Series A Preferred Shares convertible into
1,765,660 shares of common stock and issued Series B Preferred Shares convertible into 14,375,257 shares of common stock (assuming
conversion at $0.35 and excluding and Preferred Shares that may be paid as dividends). The issuance of any shares of common stock
pursuant to exercise of such options and warrants and the conversion of the debentures and Preferred Shares could be at per share
price below the offering price of shares being acquired in this offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Recent Sales of Unregistered Securities</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">None.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="A11"></A><B>MANAGEMENT&rsquo;S DISCUSSION AND ANALYSIS
OF</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FINANCIAL CONDITION AND RESULTS OF OPERATIONS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>The following discussion of our financial
condition and results of operations should be read in conjunction with our consolidated financial statements and related notes
included elsewhere in this report. This discussion contains certain forward-looking statements that involve risk and uncertainties.
Our actual results may differ materially from those discussed below. Factors that could cause or contribute to such differences
include, but are not limited to, those identified below and those set forth under the Section entitled &quot;Risk Factors&quot;,
and other documents we file with the Securities and Exchange Commission. Historical results are not necessarily indicative of future
results.</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Overview</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Q BioMed Inc. (or &ldquo;the Company&rdquo;)
was incorporated in the State of Nevada on November 22, 2013 and is a commercial stage biomedical acceleration and development
company focused on licensing, acquiring and providing strategic resources to life sciences and healthcare companies. We intend
to mitigate risk by acquiring multiple assets over time and across a broad spectrum of healthcare related products, companies and
sectors.&nbsp; We intend to develop these assets to provide returns via organic growth, revenue production, out-licensing, sale
or spin out.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Since the Company's inception, 4.5 years
ago, we have been busy building significant value ranging from blockbuster potential drugs to imminent revenue producing opportunities.
Our mission is to solve problems by accelerating the development of important therapies and availability of those therapies to
patients.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Metastron&trade; and Strontium-89 Chloride
USP Injection</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have been working hard to commercialize
Strontium-89 for the non-opiate treatment of metastatic cancer bone pain. We have settled our litigation with BioNucleonics Inc.
and now have outright ownership of the generic Strontium-89 Chloride drug, which is FDA approved. We also own Metastron&trade;,
the branded drug, purchased from GE Healthcare in November of 2018. As a result, we now control significant market share for this
injectable non-opioid metastatic cancer palliation drug in North America and much of the world.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 14, 2019, the Department of
Health and Human Services notified us that our supplemental abbreviated new drug application for a new drug product manufacturing
site, IsoTherapeutics Group, LLC, has been approved. IsoTherapeutics is now cleared to manufacture our FDA approved non-opioid
cancer bone pain drug Strontium-89 Chloride USP.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On February 13th we announced the launch
of our FDA approved non-opioid drug Strontium-89 (Strontium Chloride Sr-89 Injection, USP) which has been shown to relieve the
persistent pain associated with cancer that has metastasized to bone. In&nbsp; several multicenter, placebo-controlled trials in
cancer patients with persistent pain after external beam radiation therapy for bone metastases, pain relief occurred in more patients
treated with a single injection of Strontium-89 than in patients treated with an injection of placebo*, with a greater percentage
of patients experiencing pain scores of zero with no use of rescue opioid analgesics. Median duration of pain palliation has been
shown to be 2 to 5 months. Strontium-89 can be redosed every 90 days.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">An estimated 10 million people are living
with this condition, and due to the opioid crisis, doctors and patients are looking for an alternative to treat metastatic cancer
associated bone pain. Given that Strontium-89 can be administered every three months and proven effective in approximately 80%
of the patients who received the drug, Q BioMed is hopeful that broad market reacceptance will be swift.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have already received orders from clinics
and hospitals. Through our distribution partner, Jubilant RadiopharmaTM, we have the capability to reach patients in all 50 states.
Our contract manufacturing facility, which is FDA approved to manufacture Strontium-89, is manufacturing initial commercial-scale
quantities, with the first set of doses to be shipped in February 2020. Manufacturing will reach full production quantities in
March and patients should start to receive treatment from March onwards. Commercial and marketing activities, including conferences
and sales, will commence concurrent with commercial availability. Strontium-89 is reimbursed by Medicare and most insurance companies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This is a major milestone for Q BioMed.
We are now a revenue generating entity. This was a goal we set for ourselves when we founded the company almost 5 years ago. The
journey to producing a commercial drug has not been easy,&nbsp;but we are now there. It's a great achievement and a testament to
all those who have helped get us to this point. We look forward to being able to help serve the unmet needs of the millions of
patients suffering from debilitating pain associated with metastatic cancer in the bone. Years of well documented data prove that
Strontium-89 benefits this patient population. We believe this drug has a very important role to play as clinicians move toward
proven non-opioid therapeutics for pain palliation.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We plan to launch the drug in global markets
including Europe in 2020. Q BioMed is also planning further research for Strontium-89 for potential label extension into therapeutic
use for survival benefit in metastatic bone cancer through a Phase IV study.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In anticipation of the approval, we have
proactively on-boarded our commercial team tasked with infrastructure set-up, including: medical information and pharmacovigilance,
government contracting, marketing, contract sales and telesales. We have announced a distribution partnership with Julibilant Radiopharma
who have all the capabilities we require to access the US market, including warehousing/inventory management, invoicing and customer
service/ordering. It also has a sales team that calls on major providers, a national network of nuclear pharmacies in the U.S.
and distribution and coverage throughout the U.S. We have completed a reimbursement landscape and set our pricing strategy. Our
scientific platform is complete which is informing a creative advertising campaign to coincide with the commercial launch of our
product. We are assembling a world class scientific advisory board specific to this product to assist in market access and phase
4 clinical trial planning.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our Strontium-89 radiopharmaceutical drug
addresses an underserved patient group in the cancer pain palliation market, but also has a significant opportunity to expand into
a much larger market through our planned phase IV clinical trial designed to expand the label from a pain palliation to a cancer
therapeutic. A similar radiopharmaceutical with a much narrower indication in metastatic disease, but with survival benefits (two
months), was acquired by Bayer for $2.9 billion in 2013 and is expected to have sales exceeding $700 million this year.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The acquisition of Metastron and global
demand for access to generic drugs and non-opioid therapies has given Q BioMed access to a global market much sooner than expected
and we continue to be extremely excited about its prospects to re-establish a deserved niche in the late stage cancer treatment
landscape.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>QBM001</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">There is currently no treatment for this
20,000 US and 250,000 worldwide subgroup of autistic children that are born each year and become minimally verbal or non-verbal.
We recently filed for Orphan Drug Designation with the FDA and look forward to working with the regulators on this application.
We worked with 7 centers of excellence for autism to define a differential diagnosis for our targeted subgroup, and all are on
board. We completed a biomarker study that allows us to better define which children should be included in our planned trial. The
biomarker also provided insight into how to improve the dosing. We believe that a very targeted population with an improved, targeted
dose, will allow our planned trials to be smaller and increase the likelihood of being successful. Having also identified an autism
animal model with our biomarkers will also now accelerate our path to IND in 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Uttroside-B</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Over 40,000 liver cancer patients in the
US are diagnosed every year, and the total diagnoses per year has increased by 3% each year over the last 15 years. Each patient
has a life expectancy of less than four months. Our initial data from both animals and cell lines suggests that our developing
molecule could be very effective - as much as 10 times more effective than current treatments. As a result, we intend to bring
this product to a proof of concept trial. If demonstrated, we will actively seek partnerships in order to realize a return on our
investment. We believe that we are the only entity to have successfully synthesized Uttroside B and have filed a patent for the
synthesis. The synthesized product is now being tested and has shown exact comparison to the natural product in the same liver
cancer cell lines.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>MAN-01 and GDF15</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">There are over 60 million patients worldwide
with Primary Open-Angle Glaucoma. MAN-01 aims to reduce the pressure build-up in the eye by assisting with, and correcting, drainage
problems in tiny vessels in the eye called the Schlemm&rsquo;s Canal. MAN-01 is being designed to target these unique and extremely
important vessels, as over 70% of all fluid in the eye flows through the Schlemm&rsquo;s Canal. Currently, the MAN-01 program is
finalizing its preclinical lead candidate optimization by completing a series of ophthalmic in vivo studies to demonstrate efficacy.
After successful completion of the in vivo studies, Mannin Research will begin preparing for preclinical toxicology and filing
of its IND. Our research shows that the drug&rsquo;s mechanism of action may ameliorate vessel damage in several other diseases
such as: kidney disease, cardiovascular disease, and against infectious diseases, such as influenza and the current corona virus
outbreak. We believe these programs comprise a multi-disease platform technology that has several valuable applications. Adding
the GDF15 biomarker to our portfolio is a significant step to securing a unique product offering that put precision medicine and
patient specific treatment in the hands of clinicians. GDF15 is a companion diagnostic marker to the MAN-01 drug for determining
the severity of glaucoma using the expression levels of Growth Differentiation Factor 15 (GDF15). Determining the severity of glaucoma
using this biomarker will aid in treatment decisions for patients diagnosed with, and being treated for, glaucoma. Recent buyouts
in the Biotechnology space has us believing that large pharma companies could be looking for valuable assets like this with multiple
downlines because of expiring patient protection on current drugs. Our collaborators at the Washington University in St. Louis
are currently examining the effectiveness of GDF15 as a clinical biomarker in a clinical trial. In parallel, Q BioMed and Mannin
Research are working with the Biointerfaces Institute at McMaster University in Ontario, Canada to develop a GDF15 biomarker diagnostic
kit for monitoring glaucoma severity and progression. The aim is to develop a simple integrated diagnostic test that can be performed
at a physician&rsquo;s office with no external, expensive equipment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>The MAN Platform for other indications:</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Mannin presented positive data on a potential
new treatment for acute kidney injury (AKI) at the American Society for Nephrology 2019 Annual Meeting on November 7 in Washington
DC.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The data presented demonstrates the Ang-Tie2
signaling pathway as a promising therapeutic target for renal protection from acute kidney injury following ischemic reperfusion.
Ischemia&ndash;reperfusion (IR) injury to the kidney occurs in a range of clinically important scenarios including hypotension,
sepsis and in surgical procedures such as cardiac bypass surgery and kidney transplantation, leading to AKI. In-hospital mortality
for patients with AKI has recently been estimated to be between 20 and 25% and mortality rates in excess of 50% have been reported
in critically ill patients with AKI requiring dialysis. For those patients who survive, complications include chronic kidney disease
(CKD) and end-stage renal disease (ESRD); cardiovascular events, and reduced quality of life.&nbsp; In the United States, AKI is
associated with an increase in hospitalization costs that range from $5.4 to $24.0 billion. No effective treatments have been approved
by the FDA. This represents a very significant opportunity to advance a therapeutic in an underserved patient population.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Mannin is developing new therapeutics to
treat a variety of vascular diseases, including the new coronavirus which originated in Wuhan, China, with a rapidly rising number
of deaths and confirmed cases. The Coronavirus has been declared a Global Health Emergency by the World Health Organization (WHO).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">While Mannin is not generating a vaccine
against infectious diseases, it is developing a new drug that may increase the survival rate of patients by reducing the severity
of disease through enhancement of host-directed therapeutic response.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Mannin recently submitted a grant application
to the U.S. National Institutes of Health for Small Business Technology Transfer Grant Applications for approximately US $0.2 million
for the MAN-11 biologic. The studies will be conducted at Northwestern University to investigate treatment of vascular leakage
to treat sepsis and other infectious diseases. Mannin is also working with Canada&rsquo;s National Research Council (NRC.CNRC)
since December 2019 to support the development of the biologic. In September 2019, the German state of Saxony awarded Mannin an
approximately US $7.7 million grant to advance the Mannin portfolio of vascular diseases, including development of the biologic.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">While we continue to advance all our assets,
our key focus for both capital expense and time is on the commercialization of Strontium-89 Chloride USP Injection. This is a near-term
revenue generator and we believe a significant catalyst and long-term value driver for us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Financial Overview</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Critical Accounting Policies and Estimates</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our management's discussion and analysis
of our financial condition and results of operations is based on our audited consolidated financial statements, which have been
prepared in accordance with United States generally accepted accounting principles (&ldquo;U.S. GAAP&rdquo;). The preparation of
the consolidated financial statements requires us to make estimates and assumptions that affect the reported amounts of assets
and liabilities and the disclosure of contingent assets and liabilities at the date of the consolidated financial statements, as
well as the reported revenue generated and expenses incurred during the reporting periods. Our estimates are based on our historical
experience and on various other factors that we believe are reasonable under the circumstances, the results of which form the basis
for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual
results may differ from these estimates under different assumptions or conditions and any such differences may be material. We
believe that the accounting policies discussed below are critical to understanding our historical and future performance, as these
policies relate to the more significant areas involving management's judgments and estimates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Fair value of financial instruments</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Fair value estimates discussed herein are
based upon certain market assumptions and pertinent information available to management as of November 30, 2019 and 2018. &nbsp;The
respective carrying value of certain on-balance-sheet financial instruments approximated their fair values. These financial instruments
include cash and accounts payable. Fair values were assumed to approximate carrying values for cash and accounts payable because
they are short term in nature.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">FASB Accounting Standards Codification
(ASC) 820 &ldquo;<I>Fair Value Measurements and Disclosures</I>&rdquo; (ASC 820) defines fair value as the exchange price that
would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for
the asset or liability in an orderly transaction between market participants on the measurement date. ASC 820 also establishes
a fair value hierarchy that distinguishes between (1) market participant assumptions developed based on market data obtained from
independent sources (observable inputs) and (2) an entity&rsquo;s own assumptions about market participant assumptions developed
based on the best information available in the circumstances (unobservable inputs). The fair value hierarchy consists of three
broad levels, which gives the highest priority to unadjusted quoted prices in active markets for identical assets or liabilities
(Level 1) and the lowest priority to unobservable inputs (Level 3). The three levels of the fair value hierarchy are described
below:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&#9679;</TD><TD STYLE="text-align: justify"><B>Level 1</B>: The preferred inputs to valuation
efforts are &ldquo;quoted prices in active markets for identical assets or liabilities,&rdquo; with the caveat that the reporting
entity must have access to that market. &nbsp;Information at this level is based on direct observations of transactions involving
the same assets and liabilities, not assumptions, and thus offers superior reliability. However, relatively few items, especially
physical assets, actually trade in active markets.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&#9679;</TD><TD STYLE="text-align: justify"><B>Level 2</B>: FASB acknowledged that active markets
for identical assets and liabilities are relatively uncommon and, even when they do exist, they may be too thin to provide reliable
information. To deal with this shortage of direct data, the board provided a second level of inputs that can be applied in three
situations.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&#9679;</TD><TD STYLE="text-align: justify"><B>Level 3</B>: If inputs from levels 1 and 2 are
not available, FASB acknowledges that fair value measures of many assets and liabilities are less precise. The board describes
Level 3 inputs as &ldquo;unobservable,&rdquo; and limits their use by saying they &ldquo;shall be used to measure fair value to
the extent that observable inputs are not available.&rdquo; This category allows &ldquo;for situations in which there is little,
if any, market activity for the asset or liability at the measurement date&rdquo;. Earlier in the standard, FASB explains that
 &ldquo;observable inputs&rdquo; are gathered from sources other than the reporting company and that they are expected to reflect
assumptions made by market participants.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Fair value measurements discussed herein
are based upon certain market assumptions and pertinent information available to management as of and during the years ended November
30, 2019 and 2018. The respective carrying value of cash and accounts payable approximated their fair values as they are short
term in nature.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Intangible Assets</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Intangible assets subject to amortization
include acquired intellectual property for a marketable product acquired in November 2018. The intellectual property is being amortized
over the estimated life remaining at the time of acquisition, which is 10 years.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Intangible assets are monitored for potential
impairment whenever events or circumstances indicate that the carrying amount may not be recoverable and are also reviewed annually
to determine whether any impairment is necessary. The annual review of intangible assets is performed via a two-step process. First,
a qualitative assessment is performed to determine if it is more likely than not that the intangible asset is impaired. If required,
a quantitative assessment is performed and, if necessary, impairment is recorded.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Debt Issuance Costs</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Direct costs incurred to issue non-revolving
debt instruments are recognized as a reduction to the related debt balance in the accompanying Consolidated Balance Sheets and
amortized to interest expense over the contractual term of the related debt using the effective interest method.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Embedded Conversion Features</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We evaluate embedded conversion features
within convertible debt to determine whether the embedded conversion feature(s) should be bifurcated from the host instrument and
accounted for as a derivative at fair value with changes in fair value recorded in the Statement of Operations.&nbsp; If the conversion
feature does not require recognition of a bifurcated derivative, the convertible debt instrument is evaluated for consideration
of any beneficial conversion feature (&ldquo;BCF&rdquo;) requiring separate recognition. When we record a BCF, the intrinsic value
of the BCF is recorded as a debt discount against the face amount of the respective debt instrument (offset to additional paid-in
capital) and amortized to interest expense over the life of the debt.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Derivative Financial Instruments</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We do not use derivative instruments to
hedge exposures to cash flow, market, or foreign currency risks. We evaluate all of our financial instruments, including issued
stock purchase warrants, to determine if such instruments are derivatives or contain features that qualify as embedded derivatives.
For derivative financial instruments that are accounted for as liabilities, the derivative instrument is initially recorded at
its fair value and is then re-valued at each reporting date, with changes in the fair value reported in the Statement of Operations.
Depending on the features of the derivative financial instrument, we use either the Black-Scholes option-pricing model or a binomial
model to value the derivative instruments at inception and subsequent valuation dates.&nbsp; The classification of derivative instruments,
including whether such instruments should be recorded as liabilities or as equity, is re-assessed at the end of each reporting
period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Stock Based Compensation</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Effective December 1, 2018, the Company
adopted ASU 2018-07, by which the accounting for share-based payments to non-employees and employees is substantially aligned.
Non-employee share-based payment awards are measured at grant-date fair value of the equity instruments that the Company is obligated
to issue when the good has been delivered or the service has been rendered and any other conditions necessary to earn the right
to benefit from the instruments have been satisfied. There was no cumulative effect of the adoption of this standard.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Share-based compensation cost is recorded
for all option grants and awards of non-vested stock based on the grant date fair value of the award and is recognized over the
service period required for the award. Prior to December 1, 2018, share-based compensation cost for non-employees was remeasured
over the vesting term as earned.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Stock-based&nbsp;compensation&nbsp;expense
is recognized in the consolidated financial statements&nbsp;based&nbsp;on the fair value of the awards granted.&nbsp;Stock-based&nbsp;compensation&nbsp;cost
is measured at the grant date&nbsp;based&nbsp;on the fair value of the award and is recognized as expense over the requisite service
period, which generally represents the vesting period. We calculate the fair value of&nbsp;stock&nbsp;options using the Black-Scholes
option-pricing model at grant date.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Research and Development</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We expense the cost of research and development
as incurred.&nbsp;&nbsp;Research and development expenses comprise costs incurred in funding research and development activities,
license fees, and other external costs. Nonrefundable advance payments for goods and services that will be used in future research
and development activities are expensed when the activity is performed or when the goods have been received, rather than when payment
is made, in accordance with ASC 730,&nbsp;<I>Research and Development</I>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Income Taxes</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Deferred tax assets and liabilities are
computed based upon the difference between the financial statement and income tax basis of assets and liabilities using the enacted
marginal tax rate applicable when the related asset or liability is expected to be realized or settled. &nbsp;Deferred income tax
expenses or benefits are based on the changes in the asset or liability each period. &nbsp;If available evidence suggests that
it is more likely than not that some portion or all of the deferred tax assets will not be realized, a valuation allowance is required
to reduce the deferred tax assets to the amount that is more likely than not to be realized. Future changes in such valuation allowance
are included in the provision for deferred income taxes in the period of change.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Deferred income taxes may arise from temporary
differences resulting from income and expense items reported for financial accounting and tax purposes in different periods. &nbsp;Deferred
taxes are classified as current or non-current, depending on the classification of assets and liabilities to which they relate.
 &nbsp;Deferred taxes arising from temporary differences that are not related to an asset or liability are classified as current
or non-current depending on the periods in which the temporary differences are expected to reverse.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We apply a more-likely-than-not recognition
threshold for all tax uncertainties, which&nbsp;only allows the recognition of those tax benefits that have a greater than fifty
percent likelihood of being sustained upon examination by the taxing authorities. As of November 30,&nbsp;2019, we reviewed our
tax positions and determined there were no outstanding, or retroactive tax positions with less than a 50% likelihood of being sustained
upon examination by the taxing authorities, therefore this standard has not had a material effect on us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our policy for recording interest and penalties
associated with audits is to record such expense as a component of income tax expense. There were no amounts accrued for penalties
or interest during the years ended November 30,&nbsp;2019. Management is currently unaware of any issues under review that could
result in significant payments, accruals or material deviations from our position.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Recent accounting pronouncements</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">For a summary of recent accounting pronouncements
applicable to our consolidated financial statements, see Note 3, Summary of Significant Accounting Policies, in Part II, Item 8,
Notes to Consolidated Financial Statements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Results of Operation </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>For the fiscal years ended November
30, 2019 and 2018</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the year ended</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Operating expenses:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 72%; font-size: 10pt; text-align: left; padding-left: 9pt">General and administrative expenses</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">4,480,577</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">5,781,613</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 9pt">Research and development expenses</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">3,539,381</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">3,238,060</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 0.25in">Total operating expenses</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">8,019,958</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">9,019,673</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Other expenses:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-left: 9pt">Interest expense</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,460,384</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">162,104</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; padding-left: 9pt">Change in fair value of embedded derivatives</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">208,240</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">89,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 9pt">Loss on conversion of debt</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">591,148</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">-</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 0.25in">Total other expenses</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">2,259,772</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">251,104</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left; padding-bottom: 2.5pt">Net loss</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: right">(10,279,730</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; font-weight: bold; text-align: left">)</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: right">(9,270,777</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; font-weight: bold; text-align: left">)</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<!-- Field: Page; Sequence: 50 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font-size: 10pt"><TR STYLE="vertical-align: top; text-align: left"><TD STYLE="width: 33%">&nbsp;</TD><TD STYLE="width: 34%; text-align: center"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->43<!-- Field: /Sequence --></TD><TD STYLE="width: 33%; text-align: right">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Operating expenses</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We incur various costs and expenses in
the execution of our business. The decrease in operating expenses was mainly due to&nbsp;less professional and research &amp; development
fees incurred in connection with the license agreements with Mannin and Washington University.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Interest expenses</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following table summarizes interest&nbsp;expenses
incurred during the year ended November 30, 2019 and 2018, respectively:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;<I>&nbsp;</I></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the year ended November 30,</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 72%; font-size: 10pt; text-align: left">Interest expense based on the coupon interest rate of the outstanding debt</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">328,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">30,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Accretion of debt discount</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,001,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">132,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt">Interest expense related to deferral fee</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">131,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">-</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 2.5pt">Total interest expense</TD><TD STYLE="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right">1,460,00</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right">162,000</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Change in fair value of embedded derivatives</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We recognized a loss of approximately $0.2
million and $0.1 million resulting from the change in fair value of embedded contingent put options in convertible debentures during
the year ended November 30, 2019 and 2018, respectively. The increase is due to an increased in our outstanding convertible debentures
balance at November 30, 2019 compared to November 30, 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Loss on conversion of debt</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">During the year ended November 30, 2019,
we recognized a loss of approximately $0.6 resulting from conversion of partial 2018 Debentures and 2019 Debenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Net loss</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In the years ended November 30,&nbsp;2019
and 2018, we incurred net losses of approximately $10.3 million and $9.3 million, respectively. Our management expects to continue
to incur net losses for the foreseeable future, due to our need to continue to continue to establish a broader pipeline of assets,
expenditure on R&amp;D and implement other aspects of our business plan.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>For the three months ended February
29, 2020 and February 28, 2019</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Three Months ended</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">February 29, 2020</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">February 28, 2019</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left; padding-left: 5.4pt">Operating expenses:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 72%; font-size: 10pt; text-align: left; text-indent: 19pt; padding-left: 5.4pt">General and administrative expenses</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">5,570,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">1,243,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; text-indent: 19pt; padding-left: 5.4pt">Research and development expenses</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">263,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">814,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; text-indent: 38pt; padding-left: 5.4pt">Total operating expenses</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">5,833,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">2,057,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-indent: 38pt; padding-left: 5.4pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left; padding-left: 5.4pt">Other (income) expenses:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: 19pt; padding-left: 5.4pt">Interest expense</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">198,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">291,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; text-indent: 19pt; padding-left: 5.4pt">Change in fair value of embedded derivatives</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">(89,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">)</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">27,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; text-indent: 38pt; padding-left: 5.4pt">Total other expenses</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">109,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">318,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-indent: 19pt; padding-left: 5.4pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left; padding-bottom: 2.5pt; padding-left: 5.4pt">Net loss</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: right">(5,942,000</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; font-weight: bold; text-align: left">)</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: right">(2,375,000</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; font-weight: bold; text-align: left">)</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Operating expenses</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We incur various costs and expenses in
the execution of our business. The increase in operating expenses was mainly due to an increased charge in stock-based compensation
compared to last year. We recorded approximately $4.5 million and $0.5 million of stock-based compensation under general and administrative
expense during the three months ended February 29, 2020 and February 28, 2019, respectively.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Interest expenses</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">During the three months ended February
29, 2020, interest expense decreased to approximately $0.2 million from $0.3 million in the prior year.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following table summarizes interest&nbsp;expenses
incurred during the three months ended February 29, 2020 and February 28, 2019, respectively:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Three Months ended</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">February 29, 2020</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">February 28, 2019</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 72%; font-size: 10pt; text-align: left; padding-left: 5.4pt">Interest expense based on the coupon interest rate of the outstanding debt</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">107,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">55,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 5.4pt">Accretion of debt discount</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">91,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">236,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 2.5pt; padding-left: 5.4pt">Total interest expense</TD><TD STYLE="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right">198,000</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right">291,000</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Change in fair value of embedded derivatives</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We recognized approximately $89,000 gain
and $27,000 loss resulting from the change in fair value of embedded contingent put options in convertible notes during the three
months ended February 29, 2020 and February 28, 2019, respectively. The fluctuation is mainly due the change of stock price during
the reporting periods.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Net loss</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">During the three months ended February
29, 2020 and February 28, 2019, we incurred net losses of approximately $5.9 million and $2.4 million, respectively. &nbsp;Our
management expects to continue to incur net losses for the foreseeable future, due to our need to continue to establish a broader
pipeline of assets, expenditure on R&amp;D and implement other aspects of our business plan.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Liquidity and Capital Resources</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We prepared the accompanying consolidated
financial statements assuming that we will continue as a going concern, which contemplates the realization of assets and liquidation
of liabilities in the normal course of business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have not yet established an ongoing
source of revenues and must cover our operating through debt and equity financings to allow us to continue as a going concern.
We had approximately $0.2 million and $0.7 million in cash as of November 30, 2019 and February 29, 2020, respectively. Our ability
to continue as a going concern depends on the ability to obtain adequate capital to fund operating losses until we generate adequate
cash flows from operations to fund our operating costs and obligations. If we are unable to obtain adequate capital, we could be
forced to cease operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We depend upon our ability, and will continue
to attempt, to secure equity and/or debt financing. We cannot be certain that additional funding will be available on acceptable
terms, or at all.&nbsp;Our management determined that there was substantial doubt about our ability to continue as a going concern
within one year after the consolidated financial statements were issued, and management&rsquo;s concerns about our ability to continue
as a going concern within the year following this report persist.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The accompanying consolidated financial
statements do not include any adjustments relating to the recoverability and classification of recorded asset amounts or amounts
and classification of liabilities that might result from this uncertainty.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;<B>&nbsp;</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>For the fiscal years ended November
30, 2019 and 2018</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Cash Flows</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following table sets forth the significant
sources and uses of cash for the periods addressed in this report:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the year ended</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Net cash (used in) provided by:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 72%; font-size: 10pt; text-align: left; padding-left: 9pt">Operating activities</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">(4,105,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">)</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">(6,451,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-left: 9pt">Investing activities</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">-</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">(500,000</TD><TD STYLE="font-size: 10pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 9pt">Financing activities</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">1,593,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">8,810,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 2.5pt">Net (decrease) increase in cash</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: right">(2,512,000</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; font-weight: bold; text-align: left">)</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: right">1,860,000</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; font-weight: bold; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Net cash used in operating activities was
approximately $4.1 million for the year ended November 30, 2019 as compared to approximately $6.5 million for the year ended November
30, 2018.&nbsp; The decrease in net cash used in operating activities results from the net loss of approximately $10.3 million
for the year ended November 30, 2019, partially offset by aggregate non-cash expenses of approximately $4.7 million.&nbsp;The increase
in net cash used in operating activities results from the net loss of approximately $9.3 million for the year ended November 30,
2018, partially offset by aggregate non-cash expenses of approximately $2.9 million.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Net cash used in investing activities was
$0.5 million for the year ended November 30, 2018, resulting from purchase of intangible assets.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Net cash provided by financing activities
was approximately $1.6 million for the year ended November 30, 2019, resulting from proceeds received from the issuance of convertible
debentures payable of approximately $1.0 million and the issuance of common stock and warrants of approximately $0.6 million.&nbsp;Net
cash provided by financing activities was approximately $8.8 million for the year ended November 30, 2018, resulting from proceeds
received from the issuance of convertible debentures payable of approximately $3.9 million and the issuance of common stock and
warrants of approximately $5.4 million, offset by offering costs of approximately $0.5 million.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>For the three months ended February
29, 2020 and February 28, 2019</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Cash Flows</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following table sets forth the significant
sources and uses of cash for the periods addressed in this report:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Three Months ended</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">February 29, 2020</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">February 28, 2019</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Net cash (used in) provided by:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 72%; font-size: 10pt; text-align: left; padding-left: 9pt">Operating activities</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">(1,397,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">)</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">(1,371,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 9pt">Financing activities</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">1,965,000</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">&mdash;</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 2.5pt">Net increase (decrease) in cash</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: right">568,000</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-size: 10pt; font-weight: bold; text-align: right">(1,371,000</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; font-weight: bold; text-align: left">)</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Net cash used in operating activities was
approximately $1.4 million for the three months ended February 29, 2020 as compared to approximately $1.4 million for the three
months ended February 28, 2019.&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Net cash provided by financing activities
was approximately $2.0 million for the three months ended February 29, 2020, resulting from proceeds received from issuance of
two debentures. &nbsp;There were no activities for the three months ended February 28, 2019.&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Obligations and Commitments</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Advisory Agreements</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We entered into customary consulting arrangements
with various counterparties to provide consulting services, business development and investor relations services, pursuant to which
we agreed to issue shares of common stock as services are received.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Office Facility Agreement</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In December 2016, the Subsidiary entered
into a license to occupy a shared office facility in Cayman Islands for $30,000 per annum.&nbsp; The initial term of the agreement&nbsp;ended
in December 2019 and the Company renewed the agreement for another three years with the same terms.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This agreement does not identify a specific
asset and does not convey the use of substantially all of the shared office capacity. As such, this agreement does not contain
a lease under ASC 842. The Company recognizes monthly license payments as incurred over the term of the arrangement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The associated expense is classified within
general and administrative expenses.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>License Agreements</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Mannin</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On October 29, 2015, we entered into a
Patent and Technology License and Purchase Option Agreement (&ldquo;Exclusive License&rdquo;) with a vendor whereby we were granted
a worldwide, exclusive, license on, and option to, acquire certain intellectual property (&ldquo;Mannin IP&rdquo;) which initially
focused on developing a first-in-class eye drop treatment for glaucoma within the four-year term of the Exclusive License.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On March 26, 2019, we entered into an amendment
to the Patent and Technology License and Purchase Option Agreement that it initially entered into with Mannin Research Inc. on
October 29, 2015 (the &ldquo;Mannin Agreement&rdquo;). Under such amendment, the term of the option granted under the Mannin Agreement
was extended to October 29, 2021 in exchange for our issuing 100,000 shares to Mannin Research Inc. on April 9, 2019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">During the years ended November 30,&nbsp;2019
and 2018, we respectively incurred approximately $2.1 million in research and development expenses to fund the costs of development
of the eye drop treatment for glaucoma pursuant to the Exclusive License.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Washington University</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On&nbsp;March 9, 2019, we entered into
an Exclusive License Agreement with Washington University for license of a diagnostic marker for determining the severity of glaucoma
using the expression levels of Growth Differentiation Factor 15. The agreement calls for us to pay an initial fee of approximately
$88,000, pay annual maintenance fees ranging from $15,000 to $75,000, make additional payments upon the following milestones:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">The first commercial sale of a companion diagnostic
product;</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">&bull;</TD><TD STYLE="text-align: justify">Initiation of a clinical trial for a diagnostic product
to support FDA PMA or 510(k) regulatory approval or the foreign equivalent;</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 24px; text-align: justify"><FONT STYLE="font-size: 10pt">&bull;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">PMA or 510(k) regulatory approval by the FDA or the foreign equivalent; and</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 24px; text-align: justify"><FONT STYLE="font-size: 10pt">&bull;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">The first commercial sale of a diagnostic product.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In additional to the above payments, royalty
payments based upon sales of a companion diagnostic product or diagnostic product are required.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Related Party Transactions</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We entered into consulting agreements with
certain management personnel and stockholders for consulting and legal services.&nbsp;&nbsp;Consulting and legal expenses resulting
from such agreements were included within general and administrative expenses in the accompanying Consolidated Statements of Operations
as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>For the fiscal years ended November
30, 2019 and 2018</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the year ended November 30,</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 72%; font-size: 10pt; text-align: left">Consulting and legal expenses</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">532,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">295,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>For the three months ended February
29, 2020 and February 28, 2019</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Three Months ended</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">February 29, 2020</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">February 28, 2019</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 72%; font-size: 10pt; text-align: left; padding-left: 5.4pt">Consulting and legal expenses</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">105,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">102,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Off-Balance Sheet Arrangements</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We do not have any off-balance sheet arrangements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="A12"></A>MANAGEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Our directors and executive officers and their respective ages
as of the date of this prospectus are as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; width: 25%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Name</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; width: 3%">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 5%; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Age</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; width: 3%">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 64%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Position with the Company</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Denis Corin</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">46</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Executive Officer, Director (Chairman)</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">William Rosenstadt</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">51</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Legal Officer, Director</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Rick Panicucci</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">59</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following describes the business experience
of each of our directors and executive officers, including other directorships held in reporting companies:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Mr. Denis Corin</B>&nbsp;has been the
Chief Executive Officer and Chairman of the Board of the Company since April 21, 2015. Mr. Corin is a management consultant. He
has worked for large pharmaceutical (Novartis) and diagnostic instrumentation companies (Beckman Coulter) in their sales organizations
responsible for sales in multi-product disciplines including pharmaceuticals and diagnostics and diagnostic automation equipment.
After Novartis and Beckman Coulter, he served as Director of Investor Relations in the small-cap biotech arena at MIV Therapeutics
Inc, a company specializing in next generation drug delivery and drug eluting cardiovascular stents. Mr. Corin served as an executive
and on the board of directors of TapImmune Inc. from July 2009 to May 2012. He received his Bachelor&rsquo;s degrees in Economics
and Marketing from the University of Natal, South Africa in 1996.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Mr. William Rosenstadt</B>&nbsp;was
appointed as the Company&rsquo;s general counsel and member of the Company&rsquo;s board of directors on June 1, 2015. Mr. Rosenstadt
is a practicing corporate and securities lawyer. He is also the founding member and the managing partner of Ortoli Rosenstadt LLP,
a law firm, formed in 2006. Mr. Rosenstadt received his Juris Doctorate from Benjamin N. Cardozo School of Law in 1995 and his
Bachelor of Arts from Syracuse University in 1990.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Dr. Rick Panicucci</B>&nbsp;was appointed
as a member of the Company&rsquo;s board of directors on February 13, 2018. Dr. Panicucci specializes in the early stages of drug
discovery for various companies. His responsibilities include solid state chemistry and formulation development of all small molecule
therapeutics in early development and developing novel drug delivery technologies for small molecules and large molecules including
siRNA. Since September 2015, Dr. Panicucci has been working with one of our licensors, Mannin Research Inc., in the development
plan for MAN-01, a novel drug candidate that we license for the topical treatment of open-angle glaucoma. Since February 2015,
he has served as the Vice President of Pharmaceutical Development at WuXi AppTec, where he is responsible for providing scientific
leadership in the areas of Developability, Formulation Development and GMP Manufacturing. Prior to WuXi he held the position of
Global Head of Chemical and Pharmaceutical Profiling (CPP) at Novartis from 2004 to 2015, where he led the development and implementation
of innovative dosage form designs and continuous manufacturing paradigms. He has also held positions as the Director of Formulation
Development at Vertex Pharmaceuticals and Senior Scientist at Biogen.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Dr. Panicucci received his Ph.D. in Physical
Organic Chemistry at the University of Toronto and has two postdoctoral fellowships at University of California at Santa Barbara
and the Ontario Cancer Institute. Dr. Panicucci will continue advise on the scientific and commercial development of our MAN-01
glaucoma drug with Mannin Research Inc. He will also now provide insight and guidance on all our pipeline assets.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In connection with his service as a director,
we have entered into an agreement with Dr. Panicucci pursuant to which he will earn options to acquire up to 50,000 shares of our
common stock. The options will vest in quarterly installments of 12,500 each and are exercisable for 5 years at $3.00 per option.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Term of Office</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our directors are appointed for a one-year
term to hold office until the next annual general meeting of our stockholders or until they resign or are removed from the board
in accordance with our bylaws. Our officers are appointed by our Board of Directors and hold office until they resign or are removed
from office by the Board of Directors.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Significant Employees</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our sole employee is our Chief Executive
Officer.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Audit Committee</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We do not currently have an audit committee.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Compensation Committee</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We do not currently have compensation committee.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Involvement in Certain Legal Proceedings</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">None of our directors, executive officers
or control persons has been involved in any of the following events during the past five years: (i) any bankruptcy petition filed
by or against any business of which such person was a general partner or executive officer either at the time of the bankruptcy
or within two years prior to that time; (ii) any conviction in a criminal proceeding or being subject to a pending criminal proceeding
(excluding traffic violations and other minor offences); (iii) being subject to any order, judgment or decree, not subsequently
reversed, suspended or vacated, of any court of competent jurisdiction, permanently or temporarily enjoining, barring, suspending
or otherwise limiting his involvement in any type of business, securities or banking activities; or (iv) being found by a court
of competent jurisdiction (in a civil action), the SEC or the Commodity Futures Trading Commission to have violated a federal or
state securities or commodities law, and the judgment has not been reversed, suspended or vacated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><B>Code of Ethics</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">We have not adopted a code of corporate
conduct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><B>Compliance with Section 16(a) of
the Exchange Act</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">Section 16(a)
of the Exchange Act requires our directors and officers, and the persons who beneficially own more than 10% of our common stock,
to file reports of ownership and changes in ownership with the SEC.&nbsp;Copies of all filed reports are required to be furnished
to us pursuant to Rule 16a-3 promulgated under the Exchange Act.&nbsp;Based solely on the reports received by us and on the representations
of the reporting persons, we believe that these persons have complied with all applicable filing requirements during the year ended
November 30, 2019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="A13"></A>TRANSACTIONS WITH RELATED PERSONS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We entered into consulting agreements with
certain management personnel and stockholders for consulting and&nbsp;legal services. Consulting and legal expenses resulting from
such agreements were approximately&nbsp;$0.4 million and $0.3 million for the year ended November 30, 2019 and 2018, respectively,
and $0.1 million for the three months ended February 29, 2020.&nbsp;We do not have any obligations outstanding to other persons
who beneficially own more than 10% of our common stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="A14"></A>EXECUTIVE COMPENSATION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our directors do not receive any stated
salary for their services as directors or members of committees of the board of directors, but have received stock options for
director services and, by resolution of the board, a fixed fee may be allowed for attendance at each meeting. Directors may also
serve the Company in other capacities as an officer, agent or otherwise, and may receive compensation for their services in such
other capacity. No such fees have been paid to any director since incorporation.&nbsp;&nbsp;Reasonable travel expenses are reimbursed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Summary Compensation Table</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following table sets forth information
concerning all cash compensation awarded to, earned by or paid to all individuals serving as the Company&rsquo;s principal executive
officers during the last two completed fiscal years ended November 30, 2019 and 2018, respectively and all non-cash compensation
awarded to those same individuals in those time periods.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 8pt; font-weight: bold">Name and Principal Position</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 8pt; font-weight: bold; text-align: center">Year</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 8pt; font-weight: bold; text-align: center">Salary</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 8pt; font-weight: bold; text-align: center">Awards</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 8pt; font-weight: bold; text-align: center">Stock Awards</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 8pt; font-weight: bold; text-align: center">Warrant Awards</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 8pt; font-weight: bold; text-align: center">Option Awards</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 8pt; font-weight: bold; text-align: center">All Other Compensation</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 8pt; font-weight: bold; text-align: center">Total</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 8pt; text-align: justify; padding-left: 0.1pt; width: 24%"><FONT STYLE="font-size: 8pt">Denis Corin&nbsp;<SUP>(2)</SUP></FONT></TD><TD STYLE="width: 1%; font-size: 8pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="width: 6%; font-size: 8pt; text-align: right">2019</TD><TD STYLE="width: 5%; font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 8pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 8pt; text-align: left">$</TD><TD STYLE="width: 6%; font-size: 8pt; text-align: right">320,000</TD><TD STYLE="width: 1%; font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 8pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 8pt; text-align: left">$</TD><TD STYLE="width: 6%; font-size: 8pt; text-align: right">-</TD><TD STYLE="width: 1%; font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 8pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 8pt; text-align: left">$</TD><TD STYLE="width: 6%; font-size: 8pt; text-align: right">20,000</TD><TD STYLE="width: 1%; font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 8pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 8pt; text-align: left">$</TD><TD STYLE="width: 6%; font-size: 8pt; text-align: right">30,000</TD><TD STYLE="width: 1%; font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 8pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 8pt; text-align: left">$</TD><TD STYLE="width: 6%; font-size: 8pt; text-align: right">206,000</TD><TD STYLE="width: 1%; font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 8pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 8pt; text-align: left">$</TD><TD STYLE="width: 6%; font-size: 8pt; text-align: right">-</TD><TD STYLE="width: 1%; font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 8pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 8pt; text-align: left">$</TD><TD STYLE="width: 6%; font-size: 8pt; text-align: right">576,000</TD><TD STYLE="width: 1%; font-size: 8pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 8pt; text-align: justify; padding-left: 0.1pt">Chief Executive Officer</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt; text-align: right">2018</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">240,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">-</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">-</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">-</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">438,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">-</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">678,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 8pt; text-align: justify; padding-left: 0.1pt"><FONT STYLE="font-size: 8pt">William Rosenstadt&nbsp;<SUP>(3)</SUP></FONT></TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt; text-align: right">2019</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">-</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">-</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">72,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">99,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">206,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">313,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">690,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="white-space: nowrap; font-size: 8pt; text-align: justify; padding-left: 0.1pt">General Counsel and Director</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt; text-align: right">2018</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">-</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">-</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">59,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">-</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">438,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">331,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 8pt">&nbsp;</TD>
    <TD STYLE="font-size: 8pt; text-align: left">$</TD><TD STYLE="font-size: 8pt; text-align: right">828,000</TD><TD STYLE="font-size: 8pt; text-align: left">&nbsp;</TD></TR>
</TABLE>






<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 7%; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD STYLE="width: 93%; padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">The amounts
    represent fees paid or accrued by us to the executive officers during the past year pursuant to various employment and consulting
    services agreements, as between us and the executive officers, which are described below. Our executive officers are also
    reimbursed for any out-of-pocket expenses incurred in connection with corporate duties. We presently have no pension, health,
    annuity, insurance, profit sharing or similar benefit plans.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD STYLE="padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">Mr. Denis Corin was
    appointed as Chief Executive Officer and Director on April 21, 2015.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(3)</FONT></TD>
    <TD STYLE="padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">Mr. William Rosenstadt
    was appointed as General Counsel and Director on June 5, 2015.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(4)</FONT></TD>
    <TD><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">Mr.
        Corin was granted 40,000 shares of common stock on November 25, 2019 with grant date fair value of $20,000.</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">Mr.
        Rosenstadt was granted 115,761 shares of common stock on October 15, 2019 with grant date fair value of $72,000.</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">Mr.
        Rosenstadt was granted 20,000 shares of common stock on September 21, 2018 with grant date fair value of $59,000.&nbsp;</FONT></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(5)</FONT></TD>
    <TD><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">500,000
        warrants held by Mr. Corin was amended on October 1, 2019. The $30,000 represents the incremental value received by Mr.
        Corin.</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">Mr.
        Rosenstadt was granted 173,641 warrants on October 15, 2019 with grant date fair value of $59,000.</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">800,000
        warrants held by Mr. Rosenstadt was amended on October 1, 2019. The $40,000 represents the incremental value received
        by Mr. Rosenstadt.</FONT></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.1pt; padding-left: 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">(6)</FONT></TD>
    <TD><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">On
        May 31, 2019, Mr. Corin and Mr. Rosenstadt were each granted 150,000 stock options. The fair value on the grant date was
        $206,000, which included $40,000 incremental value from the amendment on October 1, 2019.</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt; text-align: justify"><FONT STYLE="font-size: 10pt">On
        June 1, 2018, Mr. Corin and Mr. Rosenstadt were each granted 150,000 stock options. The fair value on the grant date was
        $438,000.</FONT></P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following table sets forth information
as of November 30, 2020 relating to outstanding equity awards for each Named Executive Officer:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Outstanding Equity Awards at Year End
Table</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Name</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Number of</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Securities</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Underlying</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Unexercised</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Options</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(exercisable)</B></P></TD>
    <TD STYLE="padding-bottom: 1pt; white-space: nowrap">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Number of</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Securities</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Underlying</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Unexercised</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Options</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(unexercisable)</B></P></TD>
    <TD STYLE="padding-bottom: 1pt; white-space: nowrap">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Number of</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Securities</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Underlying</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Unexercised</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Unearned</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Options</B></P></TD>
    <TD STYLE="padding-bottom: 1pt; white-space: nowrap">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Option</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Exercise</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Price</B></P></TD>
    <TD STYLE="padding-bottom: 1pt; white-space: nowrap">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Option</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Expiration</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Date</B></P></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 31%"><FONT STYLE="font-size: 10pt">Denis Corin</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">150,000</FONT></TD>
    <TD STYLE="white-space: nowrap; width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 7%; text-align: right"><FONT STYLE="font-size: 10pt">1.45</FONT></TD>
    <TD STYLE="white-space: nowrap; width: 1%">&nbsp;</TD>
    <TD STYLE="text-align: center; width: 20%">
        <P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;July 15, 2021</P></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">500,000</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">June 5, 2022</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">150,000</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">May 31, 2023</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">150,000</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">June 5. 2024</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">750,000</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">February 10, 2025</FONT></TD></TR>
<TR STYLE="background-color: white">
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">William Rosenstadt</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">250,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">1.45</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">January 4, 2021</FONT></TD></TR>
<TR STYLE="background-color: white">
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">200,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">July 15, 2021</FONT></TD></TR>
<TR STYLE="background-color: white">
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">500,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">June 5, 2022</FONT></TD></TR>
<TR STYLE="background-color: white">
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">150,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">May 31, 2023</FONT></TD></TR>
<TR STYLE="background-color: white">
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">150,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">June 5, 2024</FONT></TD></TR>
<TR STYLE="background-color: white">
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">173,641</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">October 16, 2024</FONT></TD></TR>
<TR STYLE="background-color: white">
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">750,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">February 10, 2025</FONT></TD></TR>
<TR STYLE="background-color: white">
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">225,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">2.12</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">April 6, 2020</FONT></TD></TR>
<TR STYLE="background-color: #CCEEFF">
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Rick Panicucci</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">50,000&nbsp;</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$&nbsp;</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;February 13, 2023</FONT></TD></TR>
<TR STYLE="background-color: #CCEEFF">
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">150,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">May 31, 2023</FONT></TD></TR>
<TR STYLE="background-color: #CCEEFF">
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">150,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">June 5, 2024</FONT></TD></TR>
<TR STYLE="background-color: #CCEEFF">
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">60,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">90,000</FONT></TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: right">&nbsp;</TD>
    <TD STYLE="white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center"><FONT STYLE="font-size: 10pt">December 5, 2024</FONT></TD></TR>
<TR STYLE="background-color: rgb(204,238,255)">
    <TD STYLE="padding-bottom: 1pt; vertical-align: top">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">2,610,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">1,673,641</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; vertical-align: bottom; text-align: right"><FONT STYLE="font-size: 10pt">90,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; white-space: nowrap; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-bottom: 1pt; vertical-align: top">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="A15"></A>BENEFICIAL OWNERSHIP OF PRINCIPAL STOCKHOLDERS,
OFFICERS AND DIRECTORS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Security Ownership of Certain Beneficial Owners and Management</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following table sets forth, as of February
25, 2019, certain information regarding the ownership of our common stock by (i) each person known by us to be the beneficial owner
of more than 5% of our outstanding shares of common stock, (ii) each of our directors, (iii) our Principal Executive Officer and
(iv) all of our executive officers and directors as a group. Unless otherwise indicated, the address of each person shown is c/o
Ortoli Rosenstadt LLP, 366 Madison Avenue 3rd Floor, New York, New York 10017. Beneficial ownership, for purposes of this table,
includes options to purchase common stock that are either currently exercisable or will be exercisable within 60 days of the date
of this annual report.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: justify; border-bottom: Black 1pt solid">Name and Address of Beneficial Owner</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amount and<BR> Nature of</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Beneficial<BR> Owner (1)</B></P></TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Percent of<BR> Class (2)</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: justify">Directors and Officers:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 72%; font-size: 10pt; text-align: justify">Denis Corin (3)</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">3,391,800</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">14.5</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">%</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: justify">William Rosenstadt (4)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">2,042,222</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.5</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify">Rick Panicucci</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">140,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.2</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: justify">Directors and Officers as a Group (3)(4)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5,544,022</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">20.0</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: justify">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: justify">Major Stockholders:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: justify">Ari Jatwes (5)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,375,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.9</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; text-align: justify"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD STYLE="width: 96%; text-align: justify"><FONT STYLE="font-size: 10pt">Under Rule 13d-3, a beneficial owner of a security includes any person who, directly or indirectly, through any contract, arrangement, understanding, relationship, or otherwise has or shares: (1) voting power, which includes the power to vote, or to direct the voting of shares; and (ii) investment power, which includes the power to dispose or direct the disposition of shares. Certain shares may be deemed to be beneficially owned by more than one person (if, for example, persons share the power to vote or the power to dispose of the shares. In addition, shares&nbsp;are deemed to be beneficially owned by a person if the person has the right to acquire the shares (for example, upon the exercise of an option) within 60 days of the date as of which the information is provided. In computing the percentage ownership of any person, the amount of shares outstanding is deemed to include the amount of shares beneficially owned by such person (and only such person) by reason of these acquisition rights. As a result, the percentage of outstanding shares of any person as shown in this table does not necessarily reflect the person's actual ownership or voting power with respect to the number of shares of common stock actually outstanding as of February 25, 2019.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; text-align: justify"><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD STYLE="width: 96%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This percentage is based upon 22,468,185
        shares of common stock outstanding as of April 17, 2020 and any warrants or options exercisable by such person within 60 days of
        the date as of which the information is provided.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">(3)</FONT></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Includes (i) 150,000 five-year warrants
        issued in July 2016 for director fees, (ii) 350,000 five-year warrants issued in June 5, 2017 as a bonus for officer services through
        the date thereof, (iii) 150,000 five-year options issued on June 5, 2017 for services as a director and officer through June 1,
        2018, (iv) 150,000 five-year options issued in June 2018 for services as a director and officer through June 1, 2019 and (v) 150,000
        five-year options issued in June 2019 for services as a director and officer through June 1, 2020, all of which are exercisable
        within 60 days of the date as of which the information is provided.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">(4)</FONT></TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Includes (i) 250,000 five-year warrants
        issued in January 2016 to the law firm at Mr. Rosenstadt is a partner, (ii) 50,000 five-year warrants issued in July 2016 which
        were issued to the law firm at Mr. Rosenstadt is a partner, (iii) 150,000 five-year warrants issued in July 15, 2016 for director
        fees through June 1, 2017, (iv) 350,000 five-year warrants issued in June 2017 as a bonus for officer services through the date
        thereof, (v) 150,000 five-year options issued on June 5, 2017 for services as a director and officer through June 1, 2018, (vi)
        150,000 five-year options issued in June 2018 for services as a director and officer through June 1, 2019 and (vii) 150,000 five-year
        options issued in June 2019 for services as a director and officer through June 1, 2020, all of which are exercisable within 60
        days of the date as of which the information is provided.&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">(5)</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Includes (i) 75,000 warrants issued in July 2016, (ii) 85,000 warrants issued in June 2017, (iii) 150,000 options issued in June 2017, (iv) 50,000 options issued in July 2018, (v) 50,000 options issued in September 2019 and (vi) 300,000 warrants issued in February 2020.&nbsp;</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">There are no arrangements or understanding
among the parties set out above or their respective associates or affiliates concerning election of directors or any other matters
which may require shareholder approval.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Changes in Control</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We are unaware of any contract, or other
arrangement or provision, the operation of which may at a subsequent date result in a change of control of our Company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="A16"></A><B>LEGAL MATTERS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The legality and validity of the securities
offered from time to time under this prospectus will be passed upon by Ortoli Rosenstadt LLP. William Rosenstadt, our general counsel
and one of our directors is the managing partner of Ortoli Rosenstadt LLP.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="A17"></A>DISCLOSURE OF COMMISSION POSITION ON
INDEMNIFICATION FOR SECURITIES ACT LIABILITIES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our by-laws require us to indemnify any
of our officers or directors, and certain other persons, under certain circumstances against all expenses and liabilities incurred
or suffered by such persons because of a lawsuit or similar proceeding to which the person is made a party by reason of a his being
a director or officer of the Company or our subsidiaries, unless that indemnification is prohibited by law. We may also purchase
and maintain insurance for the benefit of any officer which may cover claims for which we could not indemnify a director or officer.
We have been advised that in the opinion of the Securities and Exchange Commission, indemnification of our officers, directors
and controlling persons under these provisions, or otherwise, is against public policy and is unenforceable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Insofar as indemnification for liabilities
arising under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), may be permitted to directors, officers
or persons controlling us pursuant to the foregoing provisions, or otherwise, we have been advised that in the opinion of the Securities
and Exchange Commission, such indemnification is against public policy as expressed in the Securities Act, and is therefore unenforceable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="A18"></A><B>EXPERTS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our financial statements as of and for
the years ended November 30, 2019 and 2018 <FONT STYLE="background-color: white">have been included in the registration statement
in reliance upon the report, which includes an explanatory paragraph as to our ability to continue as a going concern, of Marcum
LLP, independent registered public accounting firm, and upon the authority of said firm as experts in accounting and auditing.&nbsp;&nbsp;</FONT></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="A19"></A>WHERE YOU CAN FIND ADDITIONAL INFORMATION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We are a reporting company and file annual,
quarterly and current reports, proxy statements and other information with the SEC. We have filed with the SEC a registration statement
on Form S-1 under the Securities Act with respect to the securities we are offering under this prospectus. This prospectus does
not contain all of the information set forth in the registration statement and the exhibits to the registration statement. For
further information with respect to us and the securities we are offering under this prospectus, we refer you to the registration
statement and the exhibits and schedules filed as a part of the registration statement. You may read and copy the registration
statement, as well as our reports, proxy statements and other information, at the SEC&rsquo;s Public Reference Room at 100 F Street,
N.E., Washington, D.C. 20549. You can request copies of these documents by writing to the SEC and paying a fee for the copying
cost. Please call the SEC at 1-800-SEC-0330 for more information about the operation of the Public Reference Room. The SEC maintains
an internet site that contains reports, proxy and information statements, and other information regarding issuers that file electronically
with the SEC, where our SEC filings are also available. The address of the SEC&rsquo;s web site is http://www.sec.gov.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="fins"></A><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INDEX TO CONSOLIDATED FINANCIAL STATEMENTS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Page No. </TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 91%; text-align: left"><A HREF="#fins-2">Report of Independent Registered Public Accounting Firm</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; width: 7%"><A HREF="#fins-2">F-2</A></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Consolidated Financial Statements:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><A HREF="#BALANCE">Consolidated Balance Sheets as of November 30, 2019 and 2018</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><A HREF="#BALANCE">F-3</A></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><A HREF="#OPERATION">Consolidated Statements of Operations for the years ended November 30, 2019 and 2018</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><A HREF="#OPERATION">F-4</A></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><A HREF="#SHAREHOLDER">Consolidated Statements of Changes in Shareholders' Equity (Deficit) for the years ended November 30, 2019 and 2018</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><A HREF="#SHAREHOLDER">F-5</A></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><A HREF="#sp7-001">Consolidated Statements of Cash Flows for the years ended November 30, 2019 and 2018</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><A HREF="#sp7-001">F-6</A></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><A HREF="#sp7-002">Notes to Consolidated Financial Statements</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><A HREF="#sp7-002">F-7</A></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 91%"><A HREF="#fins-21">Consolidated Balance Sheets as of February 29, 2020</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; width: 7%"><A HREF="#fins-21">F-21</A></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><A HREF="#fins-22">Consolidated Statements of Operations for the quarter ended February 29, 2020</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><A HREF="#fins-22">F-22</A></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><A HREF="#fins-23">Consolidated Statements of Changes in Shareholders' Equity (Deficit) for the quarter ended February 29, 2020</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><A HREF="#fins-23">F-23</A></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><A HREF="#fins-24">Consolidated Statements of Cash Flows for the quarter ended February 29, 2020</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><A HREF="#fins-24">F-24</A></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><A HREF="#fins-25">Notes to Consolidated Financial Statements</A></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><A HREF="#fins-25">F-25</A></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>





<P STYLE="margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="fins-2"></A>REPORT OF INDEPENDENT REGISTERED PUBLIC
ACCOUNTING FIRM</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">To
the </FONT>Shareholders and Board of Directors of</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Q
BioMed</FONT> Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Opinion on the Financial Statements</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">We
have audited the accompanying consolidated balance sheets of Q BioMed</FONT> Inc. (the &ldquo;Company&rdquo;) as of November 30,
2019 and 2018, the related consolidated statements of operations<B>,</B> stockholders&rsquo; equity and cash flows for each of
the two years in the period ended November 30, 2019, and the related notes (collectively referred to as the &ldquo;financial statements&rdquo;).
In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company as of
November 30, 2019 and 2018, and the results of its operations and its cash flows for each of the two years in the period ended
November 30, 2019, in conformity with accounting principles generally accepted in the United States of America.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Explanatory Paragraph &ndash; Going Concern</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern.</FONT>
As more fully described in Note 2, the Company has a significant working capital deficiency, has incurred significant losses and
needs to raise additional funds to meet its obligations and sustain its operations. These conditions raise substantial doubt about
the Company's ability to continue as a going concern. Management's plans in regard to these matters are also described in Note
2. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Basis for Opinion</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">These</FONT>
financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on the Company's
financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight
Board (United States) (&quot;PCAOB&quot;) and are required to be independent with respect to the Company in accordance with the
U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">We
conducted our audits in accordance with the standards of the </FONT>PCAOB. Those standards require that we plan and perform the
audits to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to
error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial
reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not
for the purpose of expressing an opinion on the effectiveness of the Company's internal control over financial reporting. Accordingly,
we express no such opinion.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Our
</FONT>audits included performing procedures to assess the risks of material misstatement of the financial statements, whether
due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis,
evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting
principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements.
We believe that our audits provide a reasonable basis for our opinion.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">/s/
Marcum</FONT> <FONT STYLE="font-variant: small-caps">llp</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Marcum
</FONT><FONT STYLE="font-variant: small-caps">llp</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We have served as the Company&rsquo;s auditor since 2015<B>.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">New York, NY</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">February 28, 2020&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="BALANCE"></A>Consolidated Balance Sheets</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">As of November 30,</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">2019</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">2018</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">ASSETS</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Current assets:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; width: 68%">Cash</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 12%; text-align: right">172,636</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 12%; text-align: right">2,684,413</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Prepaid expenses and other current assets</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">17,662</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">12,500</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.375in; text-align: left">Total current assets</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">190,298</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2,696,913</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Intangible assets, net</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">450,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">500,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Total Assets</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right">640,298</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right">3,196,913</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">LIABILITIES AND STOCKHOLDERS' DEFICIT</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Current liabilities:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Accounts payable</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">652,051</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">172,628</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Accrued expenses</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,145,660</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">219,602</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Accrued expenses - related party</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">7,500</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">7,500</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Accrued interest payable</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">189,801</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">29,639</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Convertible note payable, net</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">3,243,292</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.5in; text-align: left">Total current liabilities</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">5,238,304</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">429,369</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Long-term liabilities:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Convertible notes payable, net</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">447,335</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">2,873,272</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.5in; text-align: left">Total long term liabilities</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">447,335</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">2,873,272</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Total Liabilities</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: right">5,685,639</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: right">3,302,641</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Commitments and Contingencies (Note 7)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Stockholders' Deficit:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Preferred stock, $0.001 par value; 100,000,000 shares authorized; no shares issued and outstanding as of November 30, 2019 and 2018</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Common stock, $0.001 par value; 250,000,000 shares authorized; 19,709,068 and 14,290,236 shares issued and outstanding as of November 30, 2019 and 2018, respectively</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">19,709</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">14,290</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Additional paid-in capital</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">37,328,827</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">31,994,129</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Accumulated deficit</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">(42,393,877</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">(32,114,147</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Total Stockholders' Deficit</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">(5,045,341</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">(105,728</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Total Liabilities and Stockholders' Deficit</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right">640,298</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right">3,196,913</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin: 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">The accompanying notes are an integral part
of these consolidated financial statements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="OPERATION"></A>Consolidated Statements of Operations</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center">For the year ended</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">November 30,</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">2019</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">2018</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Operating expenses:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; width: 68%; text-align: left">General and administrative expenses</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 12%; text-align: right">4,480,577</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 12%; text-align: right">5,781,613</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Research and development expenses</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">3,539,381</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">3,238,060</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.5in; text-align: left">Total operating expenses</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">8,019,958</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">9,019,673</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Other expenses:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Interest expense</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,460,384</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">162,104</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Change in fair value of embedded derivatives</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">208,240</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">89,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Loss on conversion of debt</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">591,148</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.5in; text-align: left">Total other expenses</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">2,259,772</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">251,104</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Net loss</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right">(10,279,730</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">)</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right">(9,270,777</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Net loss per share - basic and diluted</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">(0.68</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">(0.67</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">Weighted average shares outstanding, basic and diluted</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">15,040,513</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">13,735,134</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">The accompanying notes are an integral part
of these consolidated financial statements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="SHAREHOLDER"></A>Consolidated Statement of Changes in
Shareholders&rsquo; Equity (Deficit)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD COLSPAN="5" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><B>Common
                                         Stock</B></FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 8pt">Additional
                                         Paid in</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><B>Accumulated
                                         </B></FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 8pt">Total<BR>
                                         Stockholders<B>'</B></FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><B>Shares</B></FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 8pt"><B>Amount</B></FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 8pt">Capital</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 8pt">Deficit</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 8pt Times New Roman, Times, Serif">Equity
                                         (Deficit)</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>

<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 37%"><FONT STYLE="font-size: 8pt">Balance as of December
    1, 2017</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 8%; text-align: right"><FONT STYLE="font-size: 8pt">12,206,409</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-size: 8pt">$</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 8%; text-align: right"><FONT STYLE="font-size: 8pt">12,206</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-size: 8pt">$</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 12%; text-align: right"><FONT STYLE="font-size: 8pt">23,187,408</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-size: 8pt">$</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 10%; text-align: right"><FONT STYLE="font-size: 8pt">(22,843,370</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-size: 8pt">)</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-size: 8pt">$</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 10%; text-align: right"><FONT STYLE="font-size: 8pt">356,244</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">Issuance of common stock,
    warrants and options for services</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">296,952</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">297</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">2,650,180</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">2,650,477</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">Issuance of common stock
    and warrants for cash, net of offering costs</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">1,711,875</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">1,712</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">4,943,539</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">4,945,251</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">Issuance of common stock
    in connection with issuance of convertible notes</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">75,000</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">75</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">222,675</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">222,750</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">Beneficial conversion
    feature in connection with issuance of convertible notes</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">990,327</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">990,327</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">Net loss</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">(9,270,777</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left"><FONT STYLE="font-size: 8pt">)</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">(9,270,777</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left"><FONT STYLE="font-size: 8pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">Balance as of November 30, 2018</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">14,290,236</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">14,290</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">31,994,129</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">(32,114,147</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">)</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">(105,728</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">Issuance of common stock
    and warrants for cash, net of offering costs</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">1,521,602</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">1,522</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">621,728</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">623,250</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">Share based compensation
    for services</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">1,577,131</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">1,577</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">2,494,719</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">2,496,296</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">Issuance of common stock
    to convert notes payable</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">2,320,099</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">2,320</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">2,218,251</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">2,220,571</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">Net loss</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">-</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">(10,279,730</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left"><FONT STYLE="font-size: 8pt">)</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">(10,279,730</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left"><FONT STYLE="font-size: 8pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 8pt">Balance as of November 30, 2019</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">19,709,068</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">$</FONT></TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">19,709</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">$</FONT></TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">37,328,827</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">$</FONT></TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">(42,393,877</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left"><FONT STYLE="font-size: 8pt">)</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 8pt">$</FONT></TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-size: 8pt">(5,045,341</FONT></TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left"><FONT STYLE="font-size: 8pt">)</FONT></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">The accompanying notes are an integral part
of these consolidated financial statements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="sp7-001"></A>Consolidated Statement of Cash Flows</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center">For the year ended</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">November 30,</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">2019</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">2018</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Cash flows from operating activities:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.125in; width: 74%; text-align: left">Net loss</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">(10,279,730</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">(9,270,777</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.125in; text-align: left">Adjustments to reconcile net loss to net cash used in operating activities</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Share based compensation for services</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2,496,296</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2,650,477</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Change in fair value of embedded conversion option</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">208,240</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">89,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Accretion of debt discount</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,001,153</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">132,349</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Amortization expense</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">50,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Loss on conversion of debt</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">591,148</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Non-cash interest expense</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">131,265</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.125in; text-align: left">Changes in operating assets and liabilities:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Prepaid expenses</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">(5,162</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">(10,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Accounts payable and accrued expenses</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,405,481</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">(71,309</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; text-align: left">Accrued interest payable</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">296,282</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">29,639</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-left: 0.5in; text-align: left">Net cash used in operating activities</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: right">(4,105,027</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: right">(6,450,621</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Cash flows from investing activities:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.125in; text-align: left">Purchase of intangible assets</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">(500,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-left: 0.5in; text-align: left">Net cash used in investing activities</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: right">(500,000</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Cash flows from financing activities:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.125in; text-align: left">Proceeds received from issuance of convertible note, net of original issuance discount and lender's fees</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">970,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3,865,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.125in; text-align: left">Proceeds received for issuance of common stock and warrants, net of offering costs</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">623,250</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">4,945,251</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-left: 0.5in; text-align: left">Net cash provided by financing activities</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: right">1,593,250</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: right">8,810,251</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Net (decrease) increase in cash</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: right">(2,511,777</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">)</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: right">1,859,630</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Cash at beginning of the year</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: right">2,684,413</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: right">824,783</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Cash at end of the year</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right">172,636</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman, Times, Serif; text-align: right">2,684,413</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Supplemental disclosures:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Cash paid for interest</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">31,524</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Cash paid for income taxes</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Supplemental disclosures for noncash investing and financing activities:</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Issuance of common stock to convert notes payable and accrued interest</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,493,511</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Issuance of common stock in connection with issuance convertible notes</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">222,750</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">The accompanying notes are an integral part
of these consolidated financial statements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="sp7-002"></A>Notes to Consolidated Financial Statements</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Note 1 &ndash; Organization of the Company and
Description of the Business</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Q BioMed Inc. (&ldquo;Q BioMed&rdquo; or
 &ldquo;the Company&rdquo;), incorporated in the State of Nevada on November 22, 2013,&nbsp;is a biomedical acceleration and development
company focused on licensing, acquiring and providing strategic resources to life sciences and healthcare companies. Q BioMed intends
to mitigate risk by acquiring multiple assets over time and across a broad spectrum of healthcare related products, companies and
sectors.&nbsp;&nbsp;The Company intends to develop these assets to provide returns via organic growth, revenue production, out-licensing,
sale or spinoff new public companies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">On
December 7, 2016, the Company formed its wholly-owned subsidiary in Cayman Islands, &ldquo;Q BioMed Cayman SEZC&rdquo;</FONT> (the
 &ldquo;Subsidiary&rdquo;). On August 13, 2019, the Company formed its wholly-owned subsidiary in Germany, &ldquo;QBMG Q BioMed
Germany UG&rdquo;. There are no activities through November 30, 2019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The accompanying consolidated financial
statements include the accounts of the Company&rsquo;s wholly-owned subsidiary.&nbsp; All intercompany balances and transactions
have been eliminated in consolidation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note 2 &ndash; Basis of
Presentation and Going Concern</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The accompanying consolidated financial
statements are presented in U.S. dollars and have been prepared in accordance with accounting principles generally accepted in
the United States of America (&ldquo;US GAAP&rdquo;) and pursuant to the accounting and disclosure rules and regulations of the
U.S. Securities and Exchange Commission (the &ldquo;SEC&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Company currently operates in one business
segment focusing on licensing, acquiring and providing strategic resources to life sciences and healthcare companies. The Company
is not organized by market and is managed and operated as one business. A single management team reports to the chief operating
decision maker, the Chief Executive Officer, who comprehensively manages the entire business. The Company does not currently operate
any separate lines of business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Going Concern</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The accompanying consolidated financial
statements are prepared assuming the Company will continue as a going concern, which contemplates the realization of assets and
liquidation of liabilities in the normal course of business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Company has and is expected to incur
net losses and cash outflows from operations in pursuit of extracting value from its acquired intellectual property. These matters,
amongst others, raise doubt about the Company&rsquo;s ability to continue as a going concern.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
Company has not generated any revenue from operations since inception and has limited assets upon which to commence its business
operations.&nbsp;&nbsp;</FONT>Management anticipates that the Company will have to raise additional funds and/or generate revenue
from drug sales within twelve months to continue operations. Additional funding will be needed to implement the Company&rsquo;s
business plan that includes various expenses such as fulfilling our obligations under licensing agreements, legal, operational
set-up, general and administrative, marketing, employee salaries and other related start-up expenses. Obtaining additional funding
will be subject to a number of factors, including general market conditions, investor acceptance of our business plan and initial
results from our business operations. These factors may impact the timing, amount, terms or conditions of additional financing
available to us. If the Company is unable to raise sufficient funds, management will be forced to scale back the Company&rsquo;s
operations or cease its operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Management has determined that there is
substantial doubt about the Company's ability to continue as a going concern within one year after the consolidated financial statements
are issued.&nbsp;The accompanying consolidated financial statements do not include any adjustments relating to the recoverability
and classification of recorded asset amounts, or amounts and classification of liabilities that might result from this uncertainty.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note 3 &ndash; Summary of Significant
Accounting Policies</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Use of estimates</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The preparation of consolidated financial
statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts
of assets and liabilities and disclosure of contingent assets and liabilities at the date of the consolidated financial statements
and the reported amounts of revenue and expenses during the reporting period. &nbsp;Actual results may differ from those estimates,
and such differences may be material to the consolidated financial statements. The more significant estimates and assumptions by
management include among others: the valuation allowance of deferred tax assets resulting from net operating losses, the valuation
of warrants on the Company&rsquo;s stock and the valuation of embedded derivatives within the Company&rsquo;s convertible notes
payable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Concentration of Credit Risk</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.55in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Financial
instruments that potentially subject the Company to concentration of credit risk consist of cash accounts in a financial institution
which, at times </FONT>are insured by the Federal Deposit Insurance Corporation (&quot;FDIC&quot;) up to $250,000. At November
30, 2019, the Company had a cash balance that is insured by the FDIC limit.&nbsp;The Company had not experienced losses on these
accounts and management believes the Company is not exposed to significant risks on such accounts.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Fair value of financial instruments</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Fair value is defined as the price that
would be received for sale of an asset or paid for transfer of a liability, in an orderly transaction between market participants
at the measurement date.&nbsp;&nbsp;U.S. GAAP establishes a three-tier fair value hierarchy, which prioritizes the inputs used
in measuring fair value.&nbsp;&nbsp;The hierarchy gives the highest priority to unadjusted quoted prices in active markets for
identical assets or liabilities (Level 1 measurements) and the lowest priority to unobservable inputs (Level 3 measurements).&nbsp;&nbsp;These
tiers include:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Symbol"></FONT></FONT><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#9679;</P>


</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Level 1, defined as observable inputs such as quoted prices for identical instruments in active markets;</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px">&nbsp;</TD>
    <TD STYLE="width: 48px"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&#9679;<FONT STYLE="font-family: Symbol"></FONT></FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Level 2, defined as inputs other than quoted prices in active markets that are either directly or indirectly observable such as quoted prices for similar instruments in active markets or quoted prices for identical or similar instruments in markets that are not active; and</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px">&nbsp;</TD>
    <TD STYLE="width: 48px">&#9679;<FONT STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Symbol"></FONT></FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Level 3, defined as unobservable inputs in which little or no market data exists, therefore requiring an entity to develop its own assumptions, such as valuations derived from valuation techniques in which one or more significant inputs or significant value drivers are unobservable.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Fair
value measurements discussed herein are based upon certain market assumptions and pertinent information available to management
as of and during the years ended November 30, </FONT>2019 and 2018. &nbsp;The respective carrying value of cash and accounts payable
approximated their fair values as they are short term in nature.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Intangible Assets</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Intangible
assets subject to amortization include acquired intellectual property for a marketable product acquired in November 2018. The intellectual
property is being amortized over the estimated life remaining at the time of acquisition, which is 10 years</FONT>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Intangible assets are monitored for potential
impairment whenever events or circumstances indicate that the carrying amount may not be recoverable and are also reviewed annually
to determine whether any impairment is necessary. The annual review of intangible assets is performed via a two-step process. First,
a qualitative assessment is performed to determine if it is more likely than not that the intangible asset is impaired. If required,
a quantitative assessment is performed and, if necessary, impairment is recorded.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Debt Issuance Costs</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Direct costs incurred to issue non-revolving
debt instruments are recognized as a reduction to the related debt balance in the accompanying Consolidated Balance Sheets and
amortized to interest expense over the contractual term of the related debt using the effective interest method.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Embedded&nbsp;Conversion Features</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The&nbsp;Company&nbsp;evaluates&nbsp;embedded&nbsp;conversion
features within convertible debt to determine whether the embedded conversion feature(s) should be bifurcated from the host instrument
and accounted for as a derivative at fair value with changes in fair&nbsp;value&nbsp;recorded&nbsp;in the Statement of Operations.
 &nbsp;If the conversion feature&nbsp;does not require recognition of a bifurcated derivative, the convertible debt&nbsp;instrument
is evaluated for consideration of any beneficial conversion feature (&ldquo;BCF&rdquo;) requiring separate recognition. When the
Company records a BCF, the intrinsic value of the BCF is recorded as a debt discount&nbsp;against the face amount of the respective
debt instrument (offset to additional paid-in capital) and&nbsp;amortized to interest expense over the life of the debt.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Derivative Financial Instruments</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Company does not use derivative instruments
to hedge exposures to cash flow, market, or&nbsp;foreign currency risks. The Company evaluates all of its financial instruments,
including issued&nbsp;stock purchase warrants, to determine if such instruments are derivatives or contain&nbsp;features that qualify
as embedded derivatives.&nbsp;For derivative financial instruments that are accounted for as liabilities, the derivative instrument&nbsp;is
initially recorded at its fair value and is then re-valued at each reporting date, with changes in&nbsp;the fair value reported
in the Statement of Operations.&nbsp; Depending on the features of the derivative financial instrument, the Company uses either&nbsp;the
Black-Scholes option-pricing model or a binomial model&nbsp;to value the derivative instruments at inception and subsequent valuation
dates.&nbsp; The classification of derivative instruments, including whether such instruments should be recorded as liabilities
or as equity, is re-assessed at the end of each reporting period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Stock Based Compensation </I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Effective December 1, 2018, the Company
adopted ASU 2018-07, by which the accounting for share-based payments to non-employees and employees is substantially aligned.
Non-employee share-based payment awards are measured at grant-date fair value of the equity instruments that the Company is obligated
to issue when the good has been delivered or the service has been rendered and any other conditions necessary to earn the right
to benefit from the instruments have been satisfied. There was no cumulative effect of the adoption of this standard.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Share-based compensation cost is recorded
for all option grants and awards of non-vested stock based on the grant date fair value of the award, and is recognized over the
service period required for the award. Prior to December 1, 2018, share-based compensation cost for non-employees was remeasured
over the vesting term as earned.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Stock-based&nbsp;compensation&nbsp;expense
is recognized in the consolidated financial statements&nbsp;based&nbsp;on the fair value of the awards granted.&nbsp;Stock-based&nbsp;compensation&nbsp;cost
is measured at the grant date&nbsp;based&nbsp;on the fair value of the award and is recognized as expense over the requisite service
period, which generally represents the vesting period. The Company calculates the fair value of&nbsp;stock&nbsp;options using the
Black-Scholes option-pricing model at grant date.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>General and administrative expenses</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The significant components of general and
administrative expenses consist of bank fees, printing, filing fees, other office expenses, and business license
and permit fees.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Research and development</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Company expenses the cost of research
and development as incurred.&nbsp;&nbsp;Research and development expenses include costs incurred in funding research and development
activities, license fees, and other external costs. Nonrefundable advance payments for goods and services that will be used in
future research and development activities are expensed when the activity is performed or when the goods have been received, rather
than when payment is made.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Income Taxes</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Deferred tax assets and liabilities are
computed based upon the difference between the financial statement and income tax basis of assets and liabilities using the enacted
marginal tax rate applicable when the related asset or liability is expected to be realized or settled. &nbsp;Deferred income tax
expenses or benefits are based on the changes in the asset or liability each period. &nbsp;If available evidence suggests that
it is more likely than not that some portion or all of the deferred tax assets will not be realized, a valuation allowance is required
to reduce the deferred tax assets to the amount that is more likely than not to be realized. Future changes in such valuation
allowance are included in the provision for deferred income taxes in the period of change.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Deferred income taxes may arise from temporary
differences resulting from income and expense items reported for financial accounting and tax purposes in different periods. Deferred
taxes are classified as current or non-current, depending on the classification of assets and liabilities to which they relate.
Deferred taxes arising from temporary differences that are not related to an asset or liability are classified as current or non-current
depending on the periods in which the temporary differences are expected to reverse.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
Company applies a more-likely-than-not recognition threshold for all tax uncertainties, which only allows the recognition of those
tax benefits that have a greater than fifty percent likelihood of being sustained upon examination by the taxing authorities. As
of November 30, </FONT>2019, the Company reviewed its tax positions and determined there were no outstanding, or retroactive tax
positions with less than a 50% likelihood of being sustained upon examination by the taxing authorities, therefore this standard
has not had a material effect on the Company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
Company&rsquo;s policy for recording interest and penalties associated with audits is to record such expense as a component of
income tax expense. There were no amounts accrued for penalties or interest during the years ended November 30, </FONT>2019. Management
is currently unaware of any issues under review that could result in significant payments, accruals or material deviations from
its position.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Recent accounting pronouncements</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On February 2016, the FASB issued ASU No.&nbsp;2016-02,&nbsp;<I>Leases&nbsp;(Topic
842)</I>.&nbsp;Under the new guidance, lessees will be required to recognize all&nbsp;leases&nbsp;(with the exception of short-term&nbsp;leases)&nbsp;on
the balance sheet as a lease liability, which is a lessee&rsquo;s obligation to make lease payments arising from a lease, measured
on a discounted basis and a right-of-use asset, which is an asset that represents the lessee&sup1;s right to use, or control the
use of, a specified asset for the lease term.&nbsp; The guidance in ASU 2017-11 is effective for the Company on December 1, 2019.&nbsp;&nbsp;Early
adoption is permitted, and the guidance is to be applied using a full or modified retrospective approach. The Company does not
expect the adoption of the new standard to have a material impact on its Consolidated Financial Statements.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In July 2017, the FASB issued ASU 2017-11,&nbsp;<I>Earnings
Per Share (Topic 260); Distinguishing Liabilities from Equity (Topic 480); Derivatives and Hedging (Topic 815): (Part I) Accounting
for Certain Financial Instruments with Down Round Features, (Part II) Replacement of the Indefinite Deferral for Mandatorily Redeemable
Financial Instruments of Certain Nonpublic Entities and Certain Mandatorily Redeemable Noncontrolling Interests with a Scope Exception.&nbsp;</I>
The ASU&nbsp;allows companies to exclude a down round feature when determining whether a financial instrument (or embedded conversion
feature) is considered indexed to the entity&rsquo;s own stock. As a result, financial instruments (or embedded conversion features)
with down round features may no longer be required to be accounted classified as liabilities. A company will recognize the value
of a down round feature only when it is triggered and the strike price has been adjusted downward. For equity-classified freestanding
financial instruments, such as warrants, an entity will treat the value of the effect of the down round, when triggered, as a dividend
and a reduction of income available to common shareholders in computing basic earnings per share. For convertible instruments with
embedded conversion features containing down round provisions, entities will recognize the value of the down round as a beneficial
conversion discount to be amortized to earnings. The guidance in ASU 2017-11 is effective for the Company on December 1, 2019.
Early adoption is permitted, and the guidance is to be applied using a full or modified retrospective approach. The Company does
not expect the adoption of the new standard to have a material impact on its consolidated financial statements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In December 2019, the FASB issued ASU No.
2019-12, &ldquo;Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes (&ldquo;ASU 2019-12&rdquo;), which is intended
to simplify various aspects related to accounting for income taxes.&nbsp;ASU 2019-12&nbsp;removes certain exceptions to the general
principles in Topic 740 and also clarifies and amends existing guidance to improve consistent application. This guidance is effective
for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2020, with early adoption permitted.
The Company is currently evaluating the impact of this standard on its consolidated financial statements and related disclosures.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Recent adopted pronouncements</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In May 2014, the FASB issued ASU 2014-09,
<I>Revenue from Contracts with Customers (Topic 606), as modified by ASU 2015-14, Revenue from Contracts with Customers (Topic
606): Deferral of the Effective Date</I> , ASU 2016-08, <I>Revenue from Contracts with Customers (Topic 606): Principal versus
Agent Considerations (Reporting Revenue Gross versus Net),</I> ASU 2016-10, <I>Revenue from Contracts with Customers (Topic 606):
Identifying Performance Obligations and Licensing</I> , and ASU 2016-12, <I>Revenue from Contracts with Customers (Topic 606):
Narrow-Scope Improvements and Practical Expedients</I> . The revenue recognition principle in ASU 2014-09 is that an entity should
recognize revenue to depict the transfer of goods or services to customers in an amount that reflects the consideration to which
the entity expects to be entitled in exchange for those goods or services. In addition, new and enhanced disclosures will be required.
Companies may adopt the new standard either using the full retrospective approach, a modified retrospective approach with practical
expedients, or a cumulative effect upon adoption approach.&nbsp;The adoption of this standard on December 1, 2018 did not impact
the Company&rsquo;s consolidated financial statements.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">In
August 2016, the FASB issued ASU No. 2016-15, <I>Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and
Cash Payments</I>. This new standard clarifies certain aspects of the statement of cash flows, including the classification of
debt prepayment or debt extinguishment costs or other debt instruments with coupon interest rates that are insignificant in relation
to the effective interest rate of the borrowing, contingent consideration payments made after a business combination, proceeds
from the settlement of insurance claims, proceeds from the settlement of corporate-owned life insurance policies, distributions
received from equity method investees and beneficial interests in securitization transactions. This new standard also clarifies
that an entity should determine each separately identifiable source of use within the cash receipts and payments on the basis of
the nature of the underlying cash flows. In situations in which cash receipts and payments have aspects of more than one class
of cash flows and cannot be separated by source or use, the appropriate classification should depend on the activity that is likely
to be the predominant source or use of cash flows for the item. </FONT>The adoption of this standard on December 1, 2018 did not
impact the Company&rsquo;s consolidated financial statements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">In
June 2018, the FASB issued ASU 2018-07, <I>Compensation &ndash; Stock Compensation (Topic 718), Improvements to Nonemployee Share-Based
Payment Accounting</I>. This ASU is intended to simplify aspects of share-based compensation issued to non-employees by making
the guidance consistent with the accounting for employee share-based compensation. The </FONT>adoption of this standard on December
1, 2018 did not impact the Company&rsquo;s consolidated financial statements.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note 4 &ndash; Loss per share</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Basic net loss per share was calculated
by dividing net loss by the weighted-average common shares outstanding during the period.&nbsp;&nbsp;Diluted net loss per share
was calculated by dividing net loss by the weighted-average common shares outstanding during the period using the treasury stock
method or the two-class method, whichever is more dilutive. The table below summarizes&nbsp;potentially dilutive securities that
were not considered in the computation of diluted net loss per share because they would be anti-dilutive.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 76%; margin-right: 1in; margin-left: 1in">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt"><B>Potentially dilutive securities</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>November 30, 2019</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>November 30, 2018</B></FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 53%"><FONT STYLE="font-size: 10pt">Warrants</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 20%; text-align: right"><FONT STYLE="font-size: 10pt">7,179,994</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 20%; text-align: right"><FONT STYLE="font-size: 10pt">4,984,058</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD><FONT STYLE="font-size: 10pt">Convertible Notes</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">5,732,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">2,014,819</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD><FONT STYLE="font-size: 10pt">Stock Options</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,200,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">900,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Note 5 &ndash; Asset Acquisition</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 23, 2018, the Company entered
into an Asset Sale Agreement (&ldquo;ASA&rdquo;) with GE Healthcare Limited (&ldquo;GE&rdquo;) whereby the Company acquired GE&rsquo;s
radiopharmaceutical drug, Metastron&reg; and all related intellectual property including, but not limited to sales and distribution
data, market authorizations and trademarks for Metastron&reg; in various countries in exchange for an upfront payment of $500,000,
a one-time milestone payment based on future sales, and royalty payments based on future sales. The Company did not acquire any
workforce, manufacturing, inventory, sales agreements, or distribution agreements associated with Metastron&reg;. The first commercial
sale of Metastron&trade; by the Company will occur only after the successful transfer or assignment of all intellectual property,
material sales and distribution data, technical transfer and the establishment of new manufacturing sites by the Company and under
the appropriate regulatory filings required by the jurisdictions in which Metastron&trade; is sold.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
acquired assets are concentrated in a single asset and the set is not considered a business. As such, the transaction is recognized
as the acquisition of a finite-lived intangible asset. The one-time milestone payment based on future sales, and royalty payments
based on future sales will be recognized when the payments are probable and estimable, which is expected to be when the related
sales targets are achieved and the payments payable to GE. The acquired asset is being amortized on a straight-line basis over
its estimated 10 year </FONT>life. Amortization expense for the year ended November 30, 2019 was $50,000. Amortization expense
for the year ended November 30, 2018 was not significant. The estimated remaining amortization expense for each of the five succeeding
fiscal year:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 60%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif">Year ended November 30,</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 76%; text-align: left">2020</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 20%; text-align: right">50,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">2021</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">50,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">2022</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">50,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">2023</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">50,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">2024</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">50,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Thereafter</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">200,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">450,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note 6 &ndash; Convertible Notes</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B></B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 88%; margin-right: 0.5in; margin-left: 0.5in">
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; white-space: nowrap; text-align: center"><FONT STYLE="font-size: 10pt"><B>November 30, 2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; white-space: nowrap; text-align: center"><FONT STYLE="font-size: 10pt"><B>November 30, 2018</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD><FONT STYLE="font-size: 10pt"><B>Convertible Notes Payable, current:</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="width: 74%; padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Principal value of 2018 Debentures</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">2,730,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">74,299</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(61,173</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 0.5in"><FONT STYLE="font-size: 10pt">Carrying value of 2018 Debentures</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">2,743,126</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Principal value of 2019 August Debenture</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">550,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(49,834</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 0.5in"><FONT STYLE="font-size: 10pt">Carrying value of 2019 August Debenture</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">500,166</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD><FONT STYLE="font-size: 10pt"><B>Total carrying value of convertible notes payable, current</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>3,243,292</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>-</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD><FONT STYLE="font-size: 10pt"><B>Convertible Notes Payable, long-term:</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Principal value of 2018 Debentures</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">4,000,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">262,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(1,388,728</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 0.5in"><FONT STYLE="font-size: 10pt">Carrying value of 2018 Debentures</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">2,873,272</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Principal value of 2019 October Debenture</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">500,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">4,000,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">29,382</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">262,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 0.25in"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(82,047</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(1,388,728</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 0.5in"><FONT STYLE="font-size: 10pt">Carrying value of 2019 October Debenture</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">447,335</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">2,873,272</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD><FONT STYLE="font-size: 10pt"><B>Total carrying value of convertible notes, long-term</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>447,335</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>2,873,272</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I></I></P>

<!-- Field: Split-Segment; Name: 8 -->
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>2019 August Debenture</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On August 28, 2019, the Company entered
into a securities purchase agreement with an accredited investor pursuant to which the Company sold a convertible debenture (the
 &ldquo;August Debenture&rdquo;) with a maturity date of twelve months after the issuance thereof for $500,000. The August Debenture
is in the aggregate principal amount of $550,000, which amount includes an original issue discount of $40,000, and payment of the
lenders legal fees of $10,000. The August Debenture carries an interest rate of 10% per annum upon an event of default, as defined,
the outstanding balance of the August Debenture bears interest at a rate of 18% per annum. The Company may prepay the August Debenture
at 110% of the outstanding aggregate principal amount within the first six months of issuance and at 125% of the outstanding aggregate
principal amount thereafter. Since the Company can elect to settle the August Debenture in either cash or in shares, the Company
will recognize any payment in addition to the principal amount as part of debt extinguishment upon the occurrence of the payment
event.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In certain circumstances, a premium is
due upon the outstanding balance upon written notice from the lender. A premium of fifteen percent is due for each occurrence of
any major default, a premium of ten percent is due for each occurrence of an unapproved variable security issuance default, and
a premium of five percent is due for each occurrence of any minor default.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The lender has the right to convert the
outstanding aggregate principal amount at any time at the conversion price of $2.50 per share. At any time that is six months after
the issuance, the lender may redeem a portion of the August Debenture, not to exceed $150,000 in any month. The Company may pay
such a redemption in cash and/or shares of its common stock. Any payment of such a redemption in shares of common stock shall be
made at the lesser of $2.50 or 93% of the average of the four lowest VWAPs in the prior ten trading day, provided that no such
conversion price shall be less than $2.00. Any payment of such a redemption in cash shall be at 120% of the amount being redeemed.
Moreover, the Company has the right to defer up to two (2) separate redemptions for up to thirty (30) days each by providing written
notice to the lender within three (3) trading days of its receipt of a redemption notice. In the event the Company elects to exercise
its deferral right, the August Debenture&rsquo;s outstanding balance shall automatically be increased by ten percent (10%) of the
redemption amount to which such deferral relates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>2019 October Debenture</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On October&nbsp;11,&nbsp;2019, the Company
entered into another securities purchase agreement with an accredited investor to place Convertible Debentures (the &ldquo;October
Debenture&rdquo;) with a maturity date of eighteen months after the issuance thereof in the aggregate principal amount of up to
$750,000 provided that in case of an event of default, the October Debenture may become at the holder&rsquo;s election immediately
due and payable. The initial closing occurred on October 11, 2019, when the Company issued a Debenture is in the aggregate principal
amount of $500,000 for proceeds of $485,000.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The October Debenture may be converted
at any time on or prior to maturity at the lower of $1.00 or 93% of the average of the four lowest daily VWAPs during the 10 consecutive
trading days immediately preceding the conversion date, provided that as long as the Company is not in default under the October
Debenture, the conversion price may never be less than $0.50. The Company may not convert any portion of a October Debenture if
such conversion would result in the holder beneficially owning more than 4.99% of our then issued and common stock, provided that
such limitation may be waived by the holder with 65 days&rsquo; notice.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Any time after the six-month anniversary
of the issuance of the October Debenture that the daily VWAP is less than $0.50 for a period of twenty consecutive trading days
(the &ldquo;Triggering Date&rdquo;) and only for so long as such conditions exist after a Triggering Date, the Company shall make
monthly payments beginning on the last calendar day of the month when the Triggering Date occurred. Each monthly payment shall
be in an amount equal to the sum of (i) the principal amount outstanding as of the Triggering Date divided by the number of such
monthly payments until maturity, (ii) a redemption premium of 20% in respect of such principal amount and (iii) accrued and unpaid
interest hereunder as of each payment date. The Company may, no more than twice, obtain a thirty-day deferral of a monthly payment
due as a result of a Triggering Date through the payment of a deferral fee in the amount equal to 10% of the total amount of such
monthly payment. Each deferral payment may be paid by the issuance of such number of shares as is equal to the applicable deferral
payment divided by a price per share equal to 93% of the average of the four lowest daily VWAPs during the 10 consecutive Trading
Days immediately preceding the due date in respect of such monthly payment being deferred, provided that such shares issued will
be immediately freely tradable shares in the hands of the holder.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Upon issuance of the October Debenture,
the Company recognized a debt discount of approximately $89,000, resulting from the recognition of issuance costs of $15,000 and
a bifurcated embedded derivative of $74,000. &nbsp; The&nbsp;monthly payment provision within the October Debenture is a contingent
put option that is required to be separately measured at fair value, with subsequent changes in fair value recognized in the Consolidated
Statement of Operations. The fair value estimate is a Level 3 measurement. The Company estimated the fair value of the monthly
payment provision by estimating the probability of the&nbsp;occurrence of a Triggering Date and applying the probability to the
discounted maximum redemption premium for any given payment with the following key inputs:</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 95%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center">November 30, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center">October 11, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 62%">Strike price</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: right">1.00</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: right">1.00</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Terms (years)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.4</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.5</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Volatility</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">99.5</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">93.4</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">%</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Risk-free rate</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.6</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.7</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">%</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Dividend yield</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">%</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>2018 Debentures</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On September 21, 2018, the Company entered
into a securities purchase agreement with an accredited investor to place Convertible Debentures (the &ldquo;2018 Debentures&rdquo;)
with a maturity date of eighteen months after the issuance thereof in the aggregate principal amount of up to $4,000,000 (the &ldquo;Transaction&rdquo;),
provided that in case of an event of default, the 2018 Debentures may become at the holder&rsquo;s election immediately due and
payable. The initial closing of the Transaction occurred on September 21, 2018 when the Company issued a Debenture for $2,000,000.
The second closing occurred on November 1, 2018, when the Company issued another Debenture for $2,000,000. The 2018 Debentures
bear interest at the rate of 5.5% per annum. In addition, the Company paid to the holder an up-front fee equal to 2.5% of the amount
of the 2018 Debentures.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The 2018 Debentures may be converted at
any time on or prior to maturity at the lower of $4.00 or 93% of the average of the four lowest daily VWAPs during the 10 consecutive
trading days immediately preceding the conversion date, provided that as long as the Company are not in default under the 2018
Debentures, the conversion price may never be less than $2.00.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Any time after the six-month anniversary
of the issuance of a Debenture that the daily VWAP is less than $2.00 for a period of twenty consecutive trading days (the &ldquo;Triggering
Date&rdquo;) and only for so long as such conditions exist after a Triggering Date as that term is defined in the Transaction documents,
the Company shall make monthly payments beginning on the last calendar day of the month when the Triggering Date occurred. Each
monthly payment shall be in an amount equal to the sum of (i) the principal amount outstanding as of the Triggering Date divided
by the number of such monthly payments until maturity, (ii) a redemption premium of 20% in respect of such principal amount and
(iii) accrued and unpaid interest hereunder as of each payment date. The Company may, no more than twice, obtain a thirty-day deferral
of a monthly payment due as a result of a Triggering Date through the payment of a deferral fee in the amount equal to 10% of the
total amount of such monthly payment. Each deferral payment may be paid by the issuance of such number of shares as is equal to
the applicable deferral payment divided by a price per share equal to 93% of the average of the four lowest daily VWAPs during
the 10 consecutive Trading Days immediately preceding the due date in respect of such monthly payment being deferred, provided
that such shares issued will be immediately freely tradable shares in the hands of the holder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Upon issuance of the 2018 Debentures, the
Company recognized a debt discount of approximately $1.5 million, resulting from the recognition of a beneficial conversion feature
of $1.0 million, issuance costs of $358,000 and a bifurcated embedded derivative of $173,000. &nbsp;The beneficial conversion feature
was recognized as the&nbsp;intrinsic value of the&nbsp;embedded derivatives on issuance of the 2018 Debentures. &nbsp;The&nbsp;monthly
payment provision within the 2018 Debentures is a contingent put option that is required to be separately measured at fair value,
with subsequent changes in fair value recognized in the Consolidated Statement of Operations. The fair value estimate is a Level
3 measurement. The Company estimated the fair value of the monthly payment provision by estimating the probability of the&nbsp;occurrence
of a Triggering Date and applying the probability to the discounted maximum redemption premium for any given payment with the following
key inputs:</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 90%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center">November 30, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: center">November 30, 2018</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 62%">Strike price</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: right">1.00</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">$1.95 - $2.97</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Terms (years)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0.8</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">1.2 - 1.4</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Volatility</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">99.5</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">72.1% - 76.5%</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Risk-free rate</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.6</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">2.4% - 2.5%</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Dividend yield</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Debt Conversion</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following table summarizes debt conversion
during the year ended November 30, 2019:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 75%">
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 86%"><FONT STYLE="font-size: 10pt">Principal value of 2018 Debentures</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">1,270,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD><FONT STYLE="font-size: 10pt">Accrued interest</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">136,120</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">112,900</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(25,509</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-bottom: 1pt; padding-left: 9pt"><FONT STYLE="font-size: 10pt"><B>Sub-total</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>1,493,511</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">Fair value of common stock issued (2,320,099 shares)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>2,220,571</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt"><B>Loss on conversion of debt</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>595,795</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt"><B>Interest expense recognized from conversion of debt</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>131,265</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Debt Extinguishment</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On September 23, 2019, the Company amended
the conversion price of the 2018 Debentures (the &ldquo;Amendment&rdquo;). The conversion price of the 2018 Debentures was reduced
to the lower of (i) $1.00, (ii) 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately
preceding the conversion date, provided that as long as the Company is not in default under the Debentures, the conversion price
may never be less than $0.50. Additionally, the maturity date of the 2018 Debentures was extended to September 21, 2020.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Amendment was treated as an extinguishment
for accounting purposes. The following table summarizes the Amendment on September 23, 2019, which resulted in a $gain from debt
extinguishment of approximately $5,000. The gain is presented net in the Consolidated Statements of Operations with loss on the
conversion of debt.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 75%">
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 86%"><FONT STYLE="font-size: 10pt">Principal value of 2018 Debentures</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">3,565,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">697,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(418,115</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-bottom: 1pt; padding-left: 9pt"><FONT STYLE="font-size: 10pt"><B>Carrying value of 2018 Debentures on September 23, 2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>3,843,885</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD><FONT STYLE="font-size: 10pt">Principal value of modified 2018 Debentures</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">3,565,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">369,401</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(95,164</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-bottom: 1pt; padding-left: 9pt"><FONT STYLE="font-size: 10pt"><B>Fair value of amended 2018 Debentures on September 23, 2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>3,839,237</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt"><B>Gain from debt extinguishment</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>4,648</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Interest expense</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Interest expense, included in the accompanying
Consolidated Statements of Operations, is comprised of the following for each period presented:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 75%">
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>For the year ended November 30,</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>2018</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 62%"><FONT STYLE="font-size: 10pt">Interest expense based on the coupon interest rate of the outstanding debt</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 15%; text-align: right"><FONT STYLE="font-size: 10pt">327,966</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 15%; text-align: right"><FONT STYLE="font-size: 10pt">29,756</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD><FONT STYLE="font-size: 10pt">Accretion of debt discount</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,001,153</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">132,348</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">Interest expense related to deferral fee</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">131,265</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt">Total interest expense</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt">1,460,384</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt">162,104</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note 7 &ndash; Commitments and Contingencies</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Legal</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Periodically,
the Company reviews </FONT>the status of significant matters, if any exist, and assesses its potential financial exposure. If the
potential loss from any claim or legal claim is considered probable and the amount can be estimated, the Company accrues a liability
for the estimated loss.&nbsp; Legal proceedings are subject to uncertainties, and the outcomes are difficult to predict.&nbsp;
Because of such uncertainties, accruals are based on the best information available at the time.&nbsp; As additional information
becomes available, the Company reassesses the potential liability related to pending claims and litigation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>BNI matter</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">On
December 28, 2018, the Company commenced litigation against BioNucleonics, Inc. (&ldquo;BNI&rdquo;) and parties related to BNI
in the Supreme Court of New York, New York County</FONT> (removed to federal court in February 2019). The litigation stems from
a license agreement that the Company entered into with BNI in 2016 and amended from time to time. Under the agreement with BNI,
the Company were granted a worldwide, exclusive license on certain BNI intellectual property and the option to acquire the BNI
IP within three years of the agreement. The BNI IP consists of generic Strontium Chloride SR89 (generic Metastron&reg;) (&ldquo;SR89&rdquo;)
and all of BNI&rsquo;s intellectual property relating to it (&ldquo;BNI IP&rdquo;). SR89 is a radiopharmaceutical therapeutic for
cancer bone pain therapy.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
Company believes that it has fulfilled the obligations under</FONT> the agreement to exercise an option to acquire the BNI IP and
has notified BNI of such exercise, but BNI has not transferred the BNI IP to the Company. As a result, the Company has commenced
litigation to, among other actions, obtain all of the BNI IP. The Company also seeks judgments against BNI and related parties
for the misappropriation of funds, breach of contract, fraud and fraudulent inducement. In February 2019, such lawsuit was removed
to the Federal court located in the Southern District of New York. On September 23, 2019, the Company entered into a settlement
agreement with BNI and parties related to BNI. Pursuant to the terms of the settlement agreement, the Company settled its dispute
with BNI and all parties to the litigation dismissed their claims in exchange for entering into a Second Amendment to the License
Agreement (entered into on September 23, 2019) pursuant to which:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&bull;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">BNI agreed to immediately transfer and/or assign to the Company all intellectual property, patents and products that is owned by BNI that is related to Strontium-Chloride 89;</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&bull;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">The Company agreed to issue BNI 50,000 shares of its common stock upon the entry into the settlement agreement and 100,000 shares of its common stock upon the approval of the U.S. Food and Drug Administration (&ldquo;FDA&rdquo;) approval of BNI&rsquo;s Prior Approval Supplements filing</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&bull;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">The Company agreed to make a cash payment to BNI of $25,000</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&bull;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">The Company agreed to an on-going royalty payment of 3% on all gross profits derived by the Company from the sale of Strontium-Chloride 89 and MetastronTM; and</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&bull;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">The Company agreed to assume fees and expenses related to (i) all outstanding CMO fees owed by BNI to IsoTherapeutics relating to Strontium-Chloride 89 (approximately $67,000), (ii) all outstanding fees owed by BNI to the FDA relating to Strontium-Chloride 89 (approximately $208,000) and (iii) related fees for the development and approval of Strontium-Chloride 89 following the date of the settlement agreement.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Advisory Agreements</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Company entered into customary consulting
arrangements with various counterparties to provide consulting services, business development and investor relations services,
pursuant to which the Company agreed to issue shares of common stock as services are received.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Lease Agreement</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">In
December 2016, the Subsidiary entered into a lease agreement for its office space located in Cayman Islands for $30,000 per annum.&nbsp;
The initial term of the agreement </FONT>ended in December 2019 and the Company has renewed its office lease agreement for another
three years with the same terms.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Rent expense is classified within general
and administrative expenses on a straight-line basis and included in the accompanying Consolidated Statements of Operations as
follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 75%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="border-bottom: black 1pt solid; white-space: nowrap; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>For the year ended November 30,</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="white-space: nowrap">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; white-space: nowrap; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; white-space: nowrap; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>2018</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 63%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Rent expense</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">$</FONT></TD>
    <TD STYLE="width: 15%; text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">30,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">$</FONT></TD>
    <TD STYLE="width: 15%; text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">30,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>License Agreements</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Mannin</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On October 29, 2015, the Company entered
into a Patent and Technology License and Purchase Option Agreement (&ldquo;Exclusive License&rdquo;) with a vendor whereby the
Company was granted a worldwide, exclusive, license on, and option to, acquire certain intellectual property (&ldquo;Mannin IP&rdquo;)
which initially focused on developing a first-in-class eye drop treatment for glaucoma within the four-year term of the Exclusive
License.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On March 26, 2019, the Company entered
into an amendment to the Patent and Technology License and Purchase Option Agreement that it initially entered into with Mannin
Research Inc. on October 29, 2015 (the &ldquo;Mannin Agreement&rdquo;). Under such amendment, the term of the option granted under
the Mannin Agreement was extended to October 29, 2021 in exchange for the Company issuing 100,000 shares to Mannin Research Inc.
on April 9, 2019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">During
the years ended November 30, </FONT>2019 and 2018, the Company incurred approximately $2.1 million and $2.1 million, respectively,
in research and development expenses to fund the costs of development of the eye drop treatment for glaucoma pursuant to the Exclusive
License.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Washington University</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On March 9, 2019, the Company entered into
an Exclusive License Agreement with Washington University for license of a diagnostic marker for determining the severity of glaucoma
using the expression levels of Growth Differentiation Factor 15. The agreement calls for the Company to pay an initial fee of approximately
$88,000, pay annual maintenance fees ranging from $15,000 to $75,000, make additional payments upon the following milestones:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px; padding-bottom: 8pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&bull;</FONT></TD>
    <TD STYLE="padding-bottom: 8pt; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">The first commercial sale of a companion diagnostic product;</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&bull;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Initiation of a clinical trial for a diagnostic product to support FDA PMA or 510(k) regulatory approval or the foreign equivalent;</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&bull;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">PMA or 510(k) regulatory approval by the FDA or the foreign equivalent; and</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 24px">&nbsp;</TD>
    <TD STYLE="width: 24px"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&bull;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">The first commercial sale of a diagnostic product.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In additional to the above payments, royalty
payments based upon sales of a companion diagnostic product or diagnostic product are required.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note 8 - Related Party Transactions</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Company entered into consulting agreements
with certain management personnel and stockholders for consulting and legal services.&nbsp;&nbsp;Consulting and legal expenses
resulting from such agreements were included within general and administrative expenses in the accompanying Consolidated Statements
of Operations as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 75%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>For the year ended November 30,</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>2018</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 63%"><FONT STYLE="font-size: 10pt">Consulting and legal expenses</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 15%; text-align: right"><FONT STYLE="font-size: 10pt">531,751</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 15%; text-align: right"><FONT STYLE="font-size: 10pt">295,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note 9 - Stockholders&rsquo; Equity
(Deficit)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">As
of November 30, </FONT>2019, and 2018, the Company is authorized to issue up to 250,000,000 shares of its $0.001 par value common
stock and up to 100,000,000 shares of its $0.001 par value preferred stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>2019 activity</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Issuance of units in private placement
offerings</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In September 2019, the Company executed
securities purchase agreements with various investors to purchase 335,887 units, each unit consisting of (i) one share of common
stock and (ii) one and one half (1.5) warrants to purchase a share of common stock, at $0.86, which is 110% of the closing price
of the Company&rsquo;s common stock as listed on OTCQB on September 18, 2019, raising approximately $208,000 in cash.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In October and November 2019, the Company
entered into a series of securities purchase agreements for the sale of 1,185,715 units at a $0.35 per unit sales price. The Company
raised approximately $415,000 in cash. Each unit consisted of one share and one warrant to purchase a share of common stock at
an exercise price of $0.50.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif"><I>Issuance
of shares and units</I></FONT><I> for services</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">During the year ended November 30, 2019,
the Company issued an aggregate of 1,428,870 shares of the Company common stock to various vendors for advisory services, valued
at approximately $1.5 million based on the estimated fair market value of the stock on the date of grant and was recognized within
general and administrative expenses in the accompanying Consolidated Statements of Operations.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">During the year ended November 30, 2019,
the Company issued 148,261 units (with each unit consisting of one share of common stock and 1.5 warrants to purchase a share of
common stock) to the Company&rsquo;s legal counsel in exchange for $92,000 of services provided. The fair value of the units on
the issuance date was approximately $168,000. The Company recorded $76,000 as settlement cost, which is the value in excess of
the services provided. The Company&rsquo;s Chief Legal Officer and a Director is the Managing Partner at the law firm where these
services were provided.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Issuance of shares for debt
conversion</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">During the year ended November 30,
2019, the Company issued approximately 2.3 million shares of common stock to convert approximately $1.5 million outstanding
debt, including approximately $136,000 accrued interest (see Note 6).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>2018 activity</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Issued for services</I></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Company entered into customary consulting
arrangements with various counterparties to provide consulting services, business development and investor relations services.&nbsp;&nbsp;During
the year ended November 30, 2018, the Company issued an aggregate of 296,952 shares of the Company common stock to various vendors
for investor relation and introductory services, valued at approximately $800,000 based on the estimated fair market value of the
stock on the date of grant and was recognized within general and administrative expenses in the accompanying consolidated statements
of operations for the year ended November 30, 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In June 2018, the Company issued warrants
to purchase up to 84,000 shares of the Company&rsquo;s common stock to one vendor for services. The warrants are exercisable for
three years at a per share price of $3.61.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In September 2018, the Company issued warrants
to purchase up to 100,000 shares of the Company&rsquo;s common stock to one vendor for services. The warrants are exercisable for
five years at a per share price of $2.15.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Registered public financing</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On February 1, 2018, the Company sold an
aggregate of 1,711,875 shares of common stock, and 1,711,875 warrants to purchase shares of common stock, in a registered public
offering for gross proceeds of approximately $5,478,000. &nbsp;The warrants are exercisable for five years at $3.20 per share.
 &nbsp;The Company paid placement agent commissions of approximately $438,000 and issued the placement agent five-year warrants
to purchase 81,688 shares of common stock at $3.84 per share. After the placement agents&rsquo; commissions and other offering
expenses, the Company netted approximately $4,945,000 of proceeds.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note 10 - Warrants and Options</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Summary of warrants</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
following represents a summary of all outstanding warrants to purchase the Company&rsquo;s common stock, including warrants issued
to vendors for services and warrants issued as part of the units sold in the private placements, at November 30, </FONT>2019 and
2018 and the changes during the period then ended:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center">Weighted Average</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center">Weighted Average</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center">Remaining Contractual</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Warrants</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Exercise Price</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Life (years)</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Intrinsic Value</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 34%">Outstanding at December 1, 2017</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">3,083,995</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: right">3.67</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: right">4.0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">250,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in">Issued</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,977,563</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3.19</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">4.1</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; padding-bottom: 1pt">Forfeited/expired</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">(77,500</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">3.96</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Outstanding at November 30, 2018</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">4,984,058</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3.48</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3.5</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">250,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in">Issued</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3,655,936</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0.93</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3.7</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; padding-bottom: 1pt">Forfeited/expired</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">(1,460,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">3.28</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">Outstanding at November 30, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">7,179,994</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">2.22</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">3.2</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">2,463,340</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">Exercisable at November 30, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">7,129,994</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">2.22</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">3.2</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">2,463,340</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Fair value of all outstanding warrants issued for services
was calculated with the following key inputs:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 75%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">For the year ended November 30,</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">2019</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">2018</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Strike price</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">$0.39 - $2.02</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">$2.02
- $3.40 </FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Term (years)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">1.3 - 5.0</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">3.0 - 5.0</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Volatility</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">79%
- 130% </FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">123%
- 130% </FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Risk-free rate</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">1.5% - 2.8%</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">2.5% - 2.8%</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 65%; text-align: left">Dividend yield</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: center">0.0%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: center"></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; width: 1%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: center">0.0%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I></I></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Options issued for services</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">The
following represents a summary of all outstanding options to purchase the Company&rsquo;s common stock at November 30, </FONT>2019
and 2018 and the changes during the period then ended:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center">Weighted Average</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center">Weighted Average</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center">Remaining Contractual</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; text-align: center">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Options</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Exercise Price</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Life (years)</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Intrinsic Value</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 34%">Outstanding at December 1, 2017</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">450,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: right">4.00</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: right">4.5</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">220,500</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; padding-bottom: 1pt">Issued</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">450,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">3.37</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">4.5</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Outstanding at November 30, 2018</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">900,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">3.68</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">4.0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in">Issued</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1,450,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">1.31</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">2.7</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 0.25in; padding-bottom: 1pt">Forfeited/expired</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">(1,150,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">3.13</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; text-align: right">-</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">Outstanding at November 30, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">1,200,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">1.35</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">3.4</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">402,500</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">Exercisable at November 30, 2019</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">1,125,000</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">1.35</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">3.3</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman, Times, Serif; text-align: right">376,250</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Fair value of all outstanding options was
calculated with the following key inputs:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 75%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">For the year ended November 30,</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">2019</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">2018</TD><TD STYLE="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Exercise price</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">$0.43 - $1.61</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">$3.00 - $3.61</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 65%; text-align: left">Expected term (years)</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">2.7 - 5.0</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: center">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; width: 1%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: center">5.0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Volatility</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">87% - 98%</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">128% - 130%</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Risk-free rate</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">1.5% - 2.0%</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">2.5% - 2.7%</FONT></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Dividend yield</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">0.00%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"></TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">0.00%</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><I>Repricing of Existing Warrants and Options</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">On
September 24, 2019, the Company modified an aggregated of 2,610,000 stock options and warrants (the &ldquo;Options and Warrants&rdquo;)
that were originally granted to </FONT>Mr. Denis Corin, the Company&rsquo;s Chief Executive Officer and Chairman, Mr. William Rosenstadt,
the Company&rsquo;s Chief Legal Officer and a Director, and two other consultants for services provided to the Company. The exercise
price of the Options and Warrants were reduced to $1.25 per share.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Company immediately recognized $141,550
incremental stock-based compensation on October 1, 2019, and the remaining $6,000, to be fully recognized on February 29, 2020.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Stock-based Compensation</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Stock-based
compensation expense is classified within </FONT>general and administrative expenses as a result of the shares, outstanding warrants
and options issued to consultants and employees and included in the accompanying Consolidated Statements of Operations as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 80%">
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>For the year ended November 30,</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>2018</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 62%"><FONT STYLE="font-size: 10pt">Stock-based compensation expense</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 15%; text-align: right"><FONT STYLE="font-size: 10pt">2,496,296</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 15%; text-align: right"><FONT STYLE="font-size: 10pt">2,650,477</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">As
of November 30, </FONT>2019, the estimated unrecognized stock-based compensation associated with these agreements is approximately
$31,000 and will be fully recognized by February 29, 2020.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note 11 - Income Taxes</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">At
November 30, 2019, the Company has a net operating loss (&ldquo;NOL&rdquo;) carryforward for Federal and state income tax purposes
totaling approximately $24 million available to reduce future taxable income. </FONT>Of this amount, approximately $14.1 million
of Federal net operating losses are carried over indefinitely, while the remaining amount begins to expire in 2034. Some of the
state net operating losses follow the Federal Tax Cuts and Jobs Act and are carried over indefinitely, and others have various
expiration dates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The NOL carry forward is subject to review
and possible adjustment by the Internal Revenue Service and state tax authorities. Under the Internal Revenue Code (&ldquo;IRC&rdquo;)
Sections 382 and 383, annual use of the Company&rsquo;s net operating loss carryforwards to offset taxable income may be limited
based on cumulative changes in ownership. The Company has not completed an analysis to determine whether any such limitations have
been triggered as of November 30, 2019. The amount of the annual limitation, if any, will be determined based on the value of the
Company immediately prior to the ownership change. Subsequent ownership changes may further affect the limitation in future years.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<!-- Field: Page; Sequence: 78; Value: 12 -->
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    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The Company has evaluated the positive
and negative evidence bearing upon the realizability of its deferred tax assets. Based on the Company&rsquo;s history of operating
losses since inception, the Company has concluded that it is more likely than not that the benefit of its deferred tax assets will
not be realized. Accordingly, the Company has provided a full valuation allowance for deferred tax assets as of November 30, 2019
and 2018. The valuation allowance increased by approximately $3.0 million and $1.2 million for the fiscal years ended November
30, 2019 and 2018.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The tax effects of the temporary differences
and carry forwards that give rise to deferred tax assets consist of the following:&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 80%">
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>As of November 30,</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>2018</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD><FONT STYLE="font-size: 10pt">Deferred tax assets:</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 72%"><FONT STYLE="font-size: 10pt">Net-operating loss carryforward</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">8,322,959</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">5,666,313</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD><FONT STYLE="font-size: 10pt">Stock-based compensation</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">4,417,762</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">4,014,863</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD><FONT STYLE="font-size: 10pt">License agreement</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">476,906</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">463,269</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD><FONT STYLE="font-size: 10pt">Tax amortization for license agreement</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(613,954</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(221,988</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD><FONT STYLE="font-size: 10pt">Charitable contributions</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">303</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">294</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">Other accrued expenses</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">399,411</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">76,411</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD><FONT STYLE="font-size: 10pt">Total deferred tax assets</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">13,003,387</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">9,999,162</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">Valuation allowance</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(13,003,387</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(9,999,162</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt">Deferred tax asset, net of allowance</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt">-</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">A reconciliation of the statutory income tax rates and the Company&rsquo;s
effective tax rate is as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 90%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="border-bottom: black 1pt solid; white-space: nowrap; text-align: center"><FONT STYLE="font-size: 10pt"><B>For the year ended November 30,</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>2018</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 72%"><FONT STYLE="font-size: 10pt">Statutory Federal income tax rate</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">(21.0</FONT></TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">)%</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">(22.1</FONT></TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">)%</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD><FONT STYLE="font-size: 10pt">State and local taxes, net of Federal tax benefit</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(13.6</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">)%</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(11.6</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">)%</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD><FONT STYLE="font-size: 10pt">Deferred tax true-up</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">0.4</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(4.4</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">)%</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD><FONT STYLE="font-size: 10pt">Gain/loss on conversion and extinguishment of debt</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">2.0</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">0.0</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD><FONT STYLE="font-size: 10pt">Loss on settlement</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">0.3</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">0.0</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD><FONT STYLE="font-size: 10pt">Change in fair value of embedded conversion option and related accretion of interest expense</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">4.2</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">0.8</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD><FONT STYLE="font-size: 10pt">Meals and entertainment</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">0.1</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">0.0</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD><FONT STYLE="font-size: 10pt">Non-U.S. operations</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1.4</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1.3</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD><FONT STYLE="font-size: 10pt">Deferred tax rate change</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">(<FONT STYLE="font-size: 10pt">3.0</FONT></TD>
    <TD>)<FONT STYLE="font-size: 10pt">%</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">22.7</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">%</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">Change in Valuation Allowance</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">29.2</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">%</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">13.3</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">%</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt">Income Taxes Provision (Benefit)</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt">0.0</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt">%</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt">0.0</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt">%</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Company's major tax jurisdictions are the United States
and New York. All of the Company's tax years will remain open starting 2014 for examination by the Federal and state tax authorities
from the date of utilization of the net operating loss. The Company does not have any tax audits pending.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note 12 - Subsequent Events</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">On December 6,
2019, the Company issued a debenture for $1,000,000 pursuant to a securities purchase agreement with an accredited investor. The
debenture has a maturity date of June 6, 2021. The debenture bears interest at the rate of 5.5% per annum, and on issuance, the
Company paid to the holder a commitment fee equal to 2.5% of the amount of the debenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">On
</FONT>January 15, 2020, the Company issued another debenture for $1,000,000 pursuant to the same securities purchase agreement
dated December 6, 2019. The debenture has a maturity date of June 6, 2021, provided that in case of an event of default, the debenture
may become at the holder&rsquo;s election immediately due and payable. The debenture bears interest at the rate of 5.5% per annum,
and on issuance, the Company paid to the holder a commitment fee equal to 2.5% of the amount of the debenture.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On February 10, 2020, the Company issued
885,000 warrants to certain consultants and service providers in exchange for services rendered. The warrants are exercisable into
shares of the Company&rsquo;s common stock for five years from the date of issuance at an exercise price of $2.12 per share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On February 10, 2020, the Company issued
1,500,000 warrants to the Company&rsquo;s two officers in exchange for services rendered. The warrants are exercisable into shares
of the Company&rsquo;s common stock in six months from their issuance until five years from the date of issuance at an exercise
price of $2.12 per share.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B><A NAME="fins-21"></A>Q BIOMED INC.<BR>
Condensed Consolidated Balance Sheets<BR>
(Unaudited)</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 11pt Calibri,sans-serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">As of February 29,</FONT></TD><TD STYLE="font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">As of November 30,</FONT></TD><TD STYLE="font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 11pt Calibri,sans-serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-weight: bold; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">2020</FONT></TD><TD STYLE="padding-bottom: 1pt; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-weight: bold; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">2019</FONT></TD><TD STYLE="padding-bottom: 1pt; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; padding-left: 5.4pt">ASSETS</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Current assets:</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 68%; text-indent: 20pt; padding-left: 5.4pt">Cash</TD><TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 12%; text-align: right">740,644</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 12%; text-align: right">172,636</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-bottom: 1pt; text-indent: 20pt; padding-left: 5.4pt">Prepaid expenses and other current assets</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">57,162</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">17,662</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; text-indent: 30pt; padding-left: 5.4pt">Total current assets</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">797,806</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">190,298</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-bottom: 1pt; text-indent: 20pt; padding-left: 5.4pt">Intangible assets, net</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">437,500</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">450,000</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt; padding-left: 5.4pt">Total Assets</TD><TD STYLE="font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: right">1,235,306</TD><TD STYLE="padding-bottom: 2.5pt; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: right">640,298</TD><TD STYLE="padding-bottom: 2.5pt; font-weight: bold; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 11pt Calibri,sans-serif; padding-left: 5.4pt">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left; padding-left: 5.4pt">LIABILITIES AND STOCKHOLDERS' DEFICIT</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Current liabilities:</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; text-indent: 20pt; padding-left: 5.4pt">Accounts payable</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">$</TD><TD STYLE="text-align: right">436,405</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">$</TD><TD STYLE="text-align: right">652,051</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; text-indent: 20pt; padding-left: 5.4pt">Accrued expenses</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,206,881</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,145,660</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; text-indent: 20pt; padding-left: 5.4pt">Accrued expenses - related party</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,000</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">7,500</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; text-indent: 20pt; padding-left: 5.4pt">Accrued interest payable</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">211,081</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">189,801</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; padding-bottom: 1pt; text-indent: 20pt; padding-left: 5.4pt">Convertible note payable, net</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">2,250,803</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3,243,292</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-bottom: 1pt; text-indent: 40pt; padding-left: 5.4pt">Total current liabilities</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">4,109,170</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">5,238,304</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 11pt Calibri,sans-serif; text-indent: 40pt; padding-left: 5.4pt">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Long-term liabilities:</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; padding-bottom: 1pt; text-indent: 20pt; padding-left: 5.4pt">Convertible notes payable, net</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">2,356,726</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">447,335</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-bottom: 1pt; text-indent: 40pt; padding-left: 5.4pt">Total long-term liabilities</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">2,356,726</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">447,335</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left; padding-left: 5.4pt">Total Liabilities</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; text-align: right">6,465,896</TD><TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; text-align: right">5,685,639</TD><TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 11pt Calibri,sans-serif; padding-left: 5.4pt">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left; padding-left: 5.4pt">Commitments and Contingencies (Note 6)</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 11pt Calibri,sans-serif; padding-left: 5.4pt">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left; padding-left: 5.4pt">Stockholders' Deficit:</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: right">&nbsp;</TD><TD STYLE="font: 11pt Calibri,sans-serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-left: 5.4pt">Preferred stock, $0.001 par value; 100,000,000 shares authorized; no shares issued and outstanding as of February 29, 2020 and November 30, 2019</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-left: 5.4pt">Common stock, $0.001 par value; 250,000,000 shares authorized; 21,308,271 and 19,709,068 shares issued and outstanding as of February 29, 2020 and November 30, 2019, respectively</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">21,308</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">19,709</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Additional paid-in capital</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">43,083,816</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">37,328,827</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; padding-bottom: 1pt; padding-left: 5.4pt">Accumulated deficit</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(48,335,714</TD><TD STYLE="padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(42,393,877</TD><TD STYLE="padding-bottom: 1pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 1pt; padding-left: 5.4pt">Total Stockholders' Deficit</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(5,230,590</TD><TD STYLE="padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(5,045,341</TD><TD STYLE="padding-bottom: 1pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt; padding-left: 5.4pt">Total Liabilities and Stockholders' Deficit</TD><TD STYLE="font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: right">1,235,306</TD><TD STYLE="padding-bottom: 2.5pt; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: right">640,298</TD><TD STYLE="padding-bottom: 2.5pt; font-weight: bold; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">The accompanying notes are an integral part of these
condensed consolidated financial statements</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman,serif; margin-top: 0; text-align: center; margin-bottom: 8pt"><A NAME="fins-22"></A><B>Q BioMed Inc.</B><BR>
<B>Condensed Consolidated Statements of Operations</B><BR>
<B>(Unaudited)</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1pt solid; font: bold 8pt Times New Roman,serif; text-align: center">For the Three Months ended</TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">February
    29, 2020</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">February
    28, 2019</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman,serif; text-align: left; padding-left: 5.4pt">Operating expenses:</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman,serif; width: 68%; text-align: left; text-indent: 20pt; padding-left: 5.4pt">General and administrative expenses</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 12%; text-align: right">5,569,971</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 12%; text-align: right">1,242,711</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-bottom: 1pt; text-indent: 20pt; padding-left: 5.4pt">Research and development expenses</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">262,872</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">814,699</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-bottom: 1pt; text-indent: 40pt; padding-left: 5.4pt">Total operating expenses</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">5,832,843</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">2,057,410</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-indent: 40pt; padding-left: 5.4pt">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: bold 10pt Times New Roman,serif; text-align: left; padding-left: 5.4pt">Other (income) expenses:</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left; text-indent: 20pt; padding-left: 5.4pt">Interest expense</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">197,516</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">290,672</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-bottom: 1pt; text-indent: 20pt; padding-left: 5.4pt">Change in fair value of embedded derivatives</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">(88,522</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">27,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-bottom: 1pt; text-indent: 40pt; padding-left: 5.4pt">Total other expenses</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">108,994</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">317,672</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-indent: 20pt; padding-left: 5.4pt">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman,serif; text-align: left; padding-bottom: 2.5pt; padding-left: 5.4pt">Net loss</TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman,serif; text-align: right">(5,941,837</TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">)</TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: bold 10pt Times New Roman,serif; text-align: right">(2,375,082</TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-left: 5.4pt">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman,serif; text-align: left; padding-left: 5.4pt">Net loss per share - basic and diluted</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">(0.29</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">(0.16</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-left: 5.4pt">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: bold 10pt Times New Roman,serif; padding-left: 5.4pt">Weighted average shares outstanding, basic and diluted</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">20,311,768</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">14,404,289</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">The accompanying notes are an integral part of these
condensed consolidated financial statements&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;&nbsp;&nbsp;</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman,serif; margin-top: 0; text-align: center; margin-bottom: 8pt"><B><A NAME="fins-23"></A>Q BIOMED INC.</B><BR>
<B>Condensed Consolidated Statements of Changes in Shareholders&rsquo; Equity (Deficit)</B><BR>
<B>(Unaudited)</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="6" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Common Stock</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: center"><FONT STYLE="font-size: 8pt"><B>Additional Paid</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: center"><FONT STYLE="font-size: 8pt"><B>Accumulated</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: center"><FONT STYLE="font-size: 8pt"><B>Total <BR>
    Stockholders'</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Shares</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Amount</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>in Capital</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Deficit</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Equity (Deficit)</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 30%; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Balance as of December 1, 2019</B></FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt"><B>19,709,068</B></FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt"><B>19,709</B></FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt"><B>37,328,827</B></FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt"><B>(42,393,877</B></FONT></TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt"><B>(5,045,341</B></FONT></TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Issuance of common stock to convert notes payable</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,518,202</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,518</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,134,295</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,135,813</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Cashless warrants exercise</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">20,860</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">21</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(21</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Share based compensation for services</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">60,141</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">60</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">4,515,227</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">4,515,287</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Share based compensation related to warrants modification</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">105,488</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">105,488</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Net loss</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(5,941,837</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(5,941,837</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 2.5pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Balance as of February 29, 2020</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>21,308,271</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>21,308</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>43,083,816</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>(48,335,714</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>(5,230,590</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Common Stock</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Additional Paid</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Accumulated</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>Total <BR>
    Stockholders'</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Shares</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Amount</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>in Capital</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Deficit</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>Equity (Deficit)</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Balance as of December 1, 2018</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt"><B>14,290,236</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt"><B>14,290</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt"><B>31,994,129</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt"><B>(32,114,147</B></FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt"><B>(105,728</B></FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Share based compensation for services</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">175,919</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">175</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">483,600</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">483,775</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Net loss</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(2,375,082</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(2,375,082</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 2.5pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Balance as of February 28, 2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>14,466,155</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>14,465</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>32,477,729</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>(34,489,229</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>(1,997,035</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt"><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">The accompanying notes are an integral part of these
condensed consolidated financial statements</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0"><B>&nbsp;&nbsp;&nbsp;</B></P>


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    <!-- Field: /Page -->


<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B><A NAME="fins-24"></A>Q BIOMED INC.<BR>
Condensed Consolidated Statements of Cash Flows<BR>
(Unaudited)</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="6" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>For the three months
    ended</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>February 29, 2020</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>February 28, 2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Cash flows from operating activities:</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="width: 68%; padding-left: 5.4pt; text-indent: 10pt"><FONT STYLE="font-size: 10pt">Net loss</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 12%; text-align: right"><FONT STYLE="font-size: 10pt">(5,941,837</FONT></TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 12%; text-align: right"><FONT STYLE="font-size: 10pt">(2,375,082</FONT></TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 10pt"><FONT STYLE="font-size: 10pt">Adjustments to reconcile net loss to net cash used in operating activities</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Share based compensation for services</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">4,515,287</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">483,775</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Share based compensation related to warrants modification</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">105,488</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Change in fair value of embedded conversion option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(88,522</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">27,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Accretion of debt discount</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">91,184</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">236,124</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Amortization expense</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">12,500</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">12,500</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 10pt"><FONT STYLE="font-size: 10pt">Changes in operating assets and liabilities:</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Prepaid expenses</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(39,500</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">4,379</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Accounts payable and accrued expenses</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">(157,925</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">185,983</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Accrued interest payable</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">106,333</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">54,389</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 40.15pt"><FONT STYLE="font-size: 10pt"><B>Net cash used in operating activities</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>(1,396,992</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>(1,370,932</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt; text-indent: 40.15pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Cash flows from financing activities:</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 10pt"><FONT STYLE="font-size: 10pt">Proceeds received from issuance of convertible note, net of discount of $35,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">1,965,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 40.15pt"><FONT STYLE="font-size: 10pt"><B>Net cash provided by financing activities</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>1,965,000</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>&mdash;</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Net increase (decrease) in cash</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><B>568,008</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt"><B>(1,370,932</B></FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><B>)</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Cash at beginning of period</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>172,636</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>2,694,413</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 2.5pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Cash at end of the period</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>740,644</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>1,323,481</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Supplemental disclosures:</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Cash paid for interest</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Cash paid for income taxes</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Supplemental disclosures for noncash investing and financing activities:</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Issuance of common stock to convert notes payable and accrued interest</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,135,814</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Cashless warrants exercise</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">21</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">The accompanying notes are an integral part of these
condensed consolidated financial statements&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B><A NAME="fins-25"></A>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Notes to Condensed Consolidated Financial Statements</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>Note 1 - Organization of the Company and Description
of the Business</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">Q BioMed Inc. (&ldquo;Q BioMed&rdquo;) and its wholly
owned subsidiaries Q BioMed Cayman SEZC&nbsp;and QBMG Q BioMed Germany UG (collectively, &ldquo;the Company&rdquo;),&nbsp;is a
biomedical acceleration and development company focused on licensing, acquiring and providing strategic resources to life sciences
and healthcare companies. Q BioMed intends to mitigate risk by acquiring multiple assets over time and across a broad spectrum
of healthcare related products, companies and sectors.&nbsp;&nbsp;The Company intends to develop these assets to provide returns
via organic growth, revenue production, out-licensing, sale or spinoff new public companies.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The accompanying condensed consolidated financial statements
include the accounts of the Company&rsquo;s wholly-owned subsidiary.&nbsp; All intercompany balances and transactions have been
eliminated in consolidation.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>Note 2 - Basis of Presentation</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The accompanying interim period unaudited condensed
consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United
States of America (&ldquo;U.S. GAAP&rdquo;) and applicable rules and regulations of the Securities and Exchange Commission (&ldquo;SEC&rdquo;)
regarding interim financial reporting. These condensed consolidated financial statements are unaudited and should be read in conjunction
with the audited consolidated financial statements included in the Company&rsquo;s Annual Report on Form 10-K for the year ended
November 30, 2019. Certain disclosures included in the annual financial statements have been condensed or omitted from these financial
statements as they are not required for interim financial statements under U.S. GAAP and the rules of the SEC. These unaudited
consolidated financial statements reflect all adjustments that are, in the opinion of management, necessary for a fair statement
of the results for the interim periods presented. These adjustments are of a normal, recurring nature. Interim period operating
results may not be indicative of the operating results for a full year.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The Company currently operates in one business segment
focusing on licensing, acquiring and providing strategic resources to life sciences and healthcare companies. The Company is not
organized by market and is managed and operated as one business. A single management team reports to the chief operating decision
maker, the Chief Executive Officer, who comprehensively manages the entire business. The Company does not currently operate any
separate lines of business.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>Going Concern</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The accompanying condensed consolidated financial statements
are prepared assuming the Company will continue as a going concern, which contemplates the realization of assets and liquidation
of liabilities in the normal course of business.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The Company has and is expected to incur net losses
and cash outflows from operations in pursuit of extracting value from its acquired intellectual property. These matters, amongst
others, raise doubt about the Company&rsquo;s ability to continue as a going concern.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The Company has not generated any revenue from operations
since inception and has limited assets upon which to commence its business operations.&nbsp;&nbsp;Management anticipates that the
Company will have to raise additional funds and/or generate revenue from drug sales within twelve months to continue operations.
Additional funding will be needed to implement the Company&rsquo;s business plan that includes various expenses such as fulfilling
our obligations under licensing agreements, legal, operational set-up, general and administrative, marketing, employee salaries
and other related start-up expenses. Obtaining additional funding will be subject to a number of factors, including general market
conditions, investor acceptance of our business plan and initial results from our business operations. These factors may impact
the timing, amount, terms or conditions of additional financing available to us. If the Company is unable to raise sufficient funds,
management will be forced to scale back the Company&rsquo;s operations or cease its operations.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">Management has determined that there is substantial
doubt about the Company's ability to continue as a going concern within one year after the consolidated financial statements are
issued.&nbsp;The accompanying condensed consolidated financial statements do not include any adjustments relating to the recoverability
and classification of recorded asset amounts, or amounts and classification of liabilities that might result from this uncertainty.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>Note 3 - Summary of Significant Accounting Policies</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The Company&rsquo;s significant accounting policies
are disclosed in the audited financial statements for the year ended November 30, 2019 included in the Company&rsquo;s Form 10-K.
Since the date of such financial statements, there have been no changes to the Company&rsquo;s significant accounting policies.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Notes to Condensed Consolidated Financial Statements</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>Recent Accounting Standards</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">In December 2019, the FASB issued ASU No. 2019-12,
 &ldquo;Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes (&ldquo;ASU 2019-12&rdquo;), which is intended to
simplify various aspects related to accounting for income taxes.&nbsp;ASU 2019-12&nbsp;removes certain exceptions to the general
principles in Topic 740 and also clarifies and amends existing guidance to improve consistent application. This guidance is effective
for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2020, with early adoption permitted.
The Company is currently evaluating the impact of this standard on its consolidated financial statements and related disclosures.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>Recent Adopted Standards</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On February 2016, the FASB issued ASU No.&nbsp;2016-02,&nbsp;<I>Leases&nbsp;(Topic
842)</I>.&nbsp;Under the new guidance, lessees will be required to recognize all&nbsp;leases&nbsp;(with the exception of short-term&nbsp;leases)&nbsp;on
the balance sheet as a lease liability, which is a lessee&rsquo;s obligation to make lease payments arising from a lease, measured
on a discounted basis and a right-of-use asset, which is an asset that represents the lessee&sup1;s right to use, or control the
use of, a specified asset for the lease term.&nbsp; The Company adopted ASC 842 on December 1, 2019, using the optional transition
method to apply the new guidance as of December 1, 2019, rather than as of the earliest period presented, and elected the package
of practical expedients described above. The adoption of this standard on December 1, 2019 did not impact the Company&rsquo;s condensed
consolidated financial statements as the Company is not subject to any lease agreements on December 1, 2019.</P>



<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">In July 2017, the FASB issued ASU 2017-11,&nbsp;<I>Earnings
Per Share (Topic 260); Distinguishing Liabilities from Equity (Topic 480); Derivatives and Hedging (Topic 815): (Part I) Accounting
for Certain Financial Instruments with Down Round Features, (Part II) Replacement of the Indefinite Deferral for Mandatorily Redeemable
Financial Instruments of Certain Nonpublic Entities and Certain Mandatorily Redeemable Noncontrolling Interests with a Scope Exception.&nbsp;</I>
The ASU&nbsp;allows companies to exclude a down round feature when determining whether a financial instrument (or embedded conversion
feature) is considered indexed to the entity&rsquo;s own stock. As a result, financial instruments (or embedded conversion features)
with down round features may no longer be required to be accounted classified as liabilities. A company will recognize the value
of a down round feature only when it is triggered and the strike price has been adjusted downward. For equity-classified freestanding
financial instruments, such as warrants, an entity will treat the value of the effect of the down round, when triggered, as a dividend
and a reduction of income available to common shareholders in computing basic earnings per share. For convertible instruments with
embedded conversion features containing down round provisions, entities will recognize the value of the down round as a beneficial
conversion discount to be amortized to earnings. Early adoption is permitted, and the guidance is to be applied using a full or
modified retrospective approach. The adoption of this standard on December 1, 2019, did not impact the Company&rsquo;s condensed
consolidated financial statements.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>Note 4 - Loss per share</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">Basic net loss per share was calculated by dividing
net loss by the weighted-average common shares outstanding during the period.&nbsp;&nbsp;Diluted net loss per share was calculated
by dividing net loss by the weighted-average common shares outstanding during the period using the treasury stock method or the
two-class method, whichever is more dilutive. The table below summarizes&nbsp;potentially dilutive securities that were not considered
in the computation of diluted net loss per share because they would be anti-dilutive.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 80%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt"><B>Potentially dilutive securities</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>February 29, <BR>
2020</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>November 30,&nbsp;&nbsp;<BR>
2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 44%; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Warrants</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 14%; text-align: right"><FONT STYLE="font-size: 10pt">9,535,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 14%; text-align: right"><FONT STYLE="font-size: 10pt">7,180,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Convertible Notes</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">3,614,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">5,732,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Stock Options</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,350,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,200,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 12pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>Note 5 - Convertible Notes</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Notes to Condensed Consolidated Financial Statements</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>February 29, 2020</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>November 30, 2019</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt"><B>Convertible Notes Payable, current:</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 68%; padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Principal value of 2018 Debenture</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 12%; text-align: right"><FONT STYLE="font-size: 10pt">1,765,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 12%; text-align: right"><FONT STYLE="font-size: 10pt">2,730,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">4,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">74,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(33,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(61,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 40pt"><FONT STYLE="font-size: 10pt">Carrying value of 2018 Debenture</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">1,736,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">2,743,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Principal value of 2019 August Debenture</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">550,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">550,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(35,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(50,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 40pt"><FONT STYLE="font-size: 10pt">Carrying value of 2019 August Debenture</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">515,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">500,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 2.5pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Total carrying value of convertible notes payable, current</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>2,251,000</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>3,243,000</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Convertible Notes Payable, long-term:</B></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Principal value of 2019 October Debenture</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">500,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">500,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">8,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">29,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(69,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(82,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 40pt"><FONT STYLE="font-size: 10pt">Carrying value of 2019 October Debenture</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">439,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">447,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Principal value of 2019 December Debenture</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,000,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">107,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(146,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 40pt"><FONT STYLE="font-size: 10pt">Carrying value of 2019 December Debenture</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">961,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Principal value of 2020 January Debenture</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">1,000,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">107,000</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 20pt"><FONT STYLE="font-size: 10pt">Debt discount</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(150,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 40pt"><FONT STYLE="font-size: 10pt">Carrying value of 2020 January Debenture</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">957,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">&mdash;</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 2.5pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt"><B>Total carrying value of convertible notes, long-term</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>2,357,000</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>447,000</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify; background-color: white">During the quarter ended February
29, 2020, the Company raised approximately $2.0 million from issuance of various debentures (the &ldquo;Debentures&rdquo;). The
Debentures have a maturity date of June 6, 2021. The Debentures bear interest at the rate of 5.5% per annum, and on issuance, the
Company paid to the holder a commitment fee equal to 2.5% of the amount of the Debentures.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 8pt; text-align: justify">The Debentures may be converted at any time on
or prior to maturity at the lower of $3.00 or 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading
days immediately preceding the conversion date, provided that as long as we are not in default under the Debenture, the conversion
price may never be less than $2.00.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 8pt; text-align: justify">Any time after the six-month anniversary of the
issuance of the Debentures that the daily VWAP is less than $2.00 for a period of twenty consecutive trading days (the &ldquo;Triggering
Date&rdquo;) and only for so long as such conditions exist after a Triggering Date, the Company shall make monthly payments beginning
on the last calendar day of the month when the Triggering Date occurred. Each monthly payment shall be in an amount equal to the
sum of (i) the principal amount outstanding as of the Triggering Date divided by the number of such monthly payments until maturity,
(ii) a redemption premium of 20% in respect of such principal amount and (iii) accrued and unpaid interest hereunder as of each
payment date. The Company may, no more than twice, obtain a thirty-day deferral of a monthly payment due as a result of a Triggering
Date through the payment of a deferral fee in the amount equal to 10% of the total amount of such monthly payment. Each deferral
payment may be paid at the option of the Company in cash or by the issuance of such number of shares as is equal to the applicable
deferral payment divided by a price per share equal to 93% of the average of the four lowest daily VWAPs during the 10 consecutive
Trading Days immediately preceding the due date in respect of such monthly payment being deferred, provided that such shares issued
will be immediately freely tradable shares in the hands of the holder.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">Upon issuance of the Debentures, the Company recognized
a debt discount of approximately $331,000, resulting from the recognition of issuance costs of $35,000 and a bifurcated embedded
derivative of $296,000. &nbsp; The&nbsp;monthly payment provision within the Debentures is a contingent put option that is required
to be separately measured at fair value, with subsequent changes in fair value recognized in the Condensed Consolidated Statement
of Operations. The fair value estimate is a Level 3 measurement. The Company estimated the fair value of the monthly payment provision
by estimating the probability of the&nbsp;occurrence of a Triggering Date and applying the probability to the discounted maximum
redemption premium for any given payment with the following key inputs:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Notes to Condensed Consolidated Financial Statements</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 90%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: center"><FONT STYLE="font-size: 8pt"><B>&nbsp;</B></FONT></TD><TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>&nbsp;</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>January 15, 2020</B></FONT></TD><TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>&nbsp;</B></FONT></TD><TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>&nbsp;</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>December 6, 2019</B></FONT></TD><TD STYLE="padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt"><B>&nbsp;</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 64%; padding-left: 5.4pt">Strike price</TD><TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 14%; text-align: right">3.00</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 14%; text-align: right">3.00</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Terms (years)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.4</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.5</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-left: 5.4pt">Volatility</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">97%</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">98%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Risk-free rate</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.7%</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.6%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Dividend yield</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0%</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">The fair value of the monthly payment provision in all outstanding debentures
with the feature are revalued as of February 29, 2020 based on the following key inputs:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Calibri,sans-serif; margin: 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 80%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 11pt Calibri,sans-serif"><FONT STYLE="font-size: 8pt"><B>&nbsp;</B></FONT></TD><TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt"><B>&nbsp;</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 8pt"><B>February 29, 2020</B></FONT></TD><TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt"><B>&nbsp;</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-left: 5.4pt">Strike price</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman,serif">&nbsp;$1.00 - $3.00 </FONT></TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 82%; text-align: left; padding-left: 5.4pt">Terms (years)</TD><TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 14%; text-align: right">1.0</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-left: 5.4pt">Volatility</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">101%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Risk-free rate</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Dividend yield</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>Debt Conversion</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The following table summarizes debt conversion during
the three months ended February 29, 2020:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 80%">
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 82%; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Principal value of 2018 Debenture</FONT></TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 14%; text-align: right"><FONT STYLE="font-size: 10pt">965,000</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Accrued interest</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">85,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Fair value of bifurcated contingent put option</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">86,000</FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 1pt; padding-left: 5.4pt; text-indent: 10.05pt"><FONT STYLE="font-size: 10pt"><B>Sub-total</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt"><B>1,136,000</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding-left: 5.4pt; text-indent: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding-bottom: 2.5pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">Fair value of common stock issued (974,871 shares)</FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt"><B>$</B></FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt"><B>1,136,000</B></FONT></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>Interest expense</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">Interest expense, included in the accompanying Condensed
Consolidated Statements of Operations, is comprised of the following for each period presented:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 80%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 11pt Calibri,sans-serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">For
    the Three Months ended</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 11pt Calibri,sans-serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">February
    29, 2020</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">February
    28, 2019</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; width: 64%; text-align: left; padding-left: 5.4pt">Interest expense based on the coupon interest rate of the outstanding debt</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 14%; text-align: right">107,000</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 14%; text-align: right">55,000</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-bottom: 1pt; padding-left: 5.4pt">Accretion of debt discount</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">91,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">236,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-bottom: 2.5pt; padding-left: 5.4pt">Total interest expense</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">198,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">291,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>Note 6 - Commitments and Contingencies</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>Legal</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">Periodically, the Company reviews&nbsp;the status of
significant matters, if any exist, and assesses its potential financial exposure. If the potential loss from any claim or legal
claim is considered probable and the amount can be estimated, the Company accrues a liability for the estimated loss.&nbsp; Legal
proceedings are subject to uncertainties, and the outcomes are difficult to predict.&nbsp; Because of such uncertainties, accruals
are based on the best information available at the time.&nbsp; As additional information becomes available, the Company reassesses
the potential liability related to pending claims and litigation.</P>


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<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Notes to Condensed Consolidated Financial Statements</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>Advisory Agreements</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The Company entered into customary consulting arrangements
with various counterparties to provide consulting services, business development and investor relations services, pursuant to which
the Company agreed to issue shares of common stock as services are received.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Office Facility Agreement</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">In December 2016, the Subsidiary entered
into a license to occupy a shared office facility in Cayman Islands for $30,000 per annum.&nbsp; The initial term of the agreement&nbsp;ended
in December 2019 and the Company renewed the agreement for another three years with the same terms.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">This agreement does not identify a specific
asset and does not convey the use of substantially all of the shared office capacity. As such, this agreement does not contain
a lease under ASC 842. The Company recognizes monthly license payments as incurred over the term of the arrangement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The associated expense is classified within
general and administrative expenses.</P>



<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0"><B>Note 7 - Related Party Transactions</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The Company entered into consulting agreements with
certain management personnel and stockholders for consulting and legal services. Consulting and legal expenses resulting from such
agreements were included within general and administrative expenses in the accompanying Condensed Consolidated Statements of Operations
as follows:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 80%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 11pt Calibri,sans-serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">For
    the Three Months ended</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 11pt Calibri,sans-serif; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">February
    29, 2020</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">February
    28, 2019</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; width: 64%; text-align: left; padding-left: 5.4pt">Consulting and legal expenses</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 14%; text-align: right">105,000</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 14%; text-align: right">102,000</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>Note 8 - Stockholders&rsquo; Equity Deficit</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>Issuance of shares for services</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">During the three months ended February 29, 2020, the
Company issued an aggregate of 60,141 shares of the Company common stock to various vendors for advisory services, valued at approximately
$0.1 million based on the estimated fair market value of the stock on the date of grant and was recognized within general and administrative
expenses in the accompanying Condensed Consolidated Statements of Operations.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>Note 9 - Warrants and Options</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>Summary of warrants</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The following represents a summary of all outstanding
warrants to purchase the Company&rsquo;s common stock, including warrants issued to vendors for services and warrants issued as
part of the units sold in the private placements, at February 29, 2020 and the changes during the period then ended:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Notes to Condensed Consolidated Financial Statements</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>







<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 11pt Calibri, Helvetica, Sans-Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">Weighted Average</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">Weighted Average</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">Remaining <BR>
    Contractual</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">Warrants</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">Exercise
    Price</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">Life
    (years)</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman,serif; text-align: center"><FONT STYLE="font-size: 8pt">Intrinsic
    Value</FONT></TD><TD STYLE="font: bold 10pt Times New Roman,serif; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; width: 35%; text-align: left"><FONT STYLE="font: 10pt Times New Roman,serif">Outstanding at December 1, 2019</FONT></TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 12%; text-align: right">7,180,000</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 12%; text-align: right">2.22</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 12%; text-align: right">3.2</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 12%; text-align: right">2,463,000</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left"><FONT STYLE="font: 10pt Times New Roman,serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Issued</FONT></TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">2,631,000</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">2.14</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">4.9</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">&mdash;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font: 10pt Times New Roman,serif">Cashless exercise</FONT></TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">(30,000</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">0.86</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">&mdash;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: right">&mdash;</TD><TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font: 10pt Times New Roman,serif">Forfeited/expired</FONT></TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">(246,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">4.01</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">&mdash;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">&mdash;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left"><FONT STYLE="font: 10pt Times New Roman,serif">Outstanding at February 29, 2020</FONT></TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">9,535,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">2.14</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">3.5</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">8,680,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left"><FONT STYLE="font: 10pt Times New Roman,serif">Exercisable at February 29, 2020</FONT></TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">9,497,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">2.14</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">3.5</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">8,656,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">On February 10, 2020, the Company issued 885,000 warrants
to certain consultants and service providers in exchange for services rendered. The warrants are exercisable into shares of the
Company&rsquo;s common stock for five years from the date of issuance at an exercise price of $2.12 per share.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">On February 10, 2020, the Company issued 1,500,000
warrants to the Company&rsquo;s two officers in exchange for services rendered. The warrants are exercisable into shares of the
Company&rsquo;s common stock in six months from their issuance until five years from the date of issuance at an exercise price
of $2.12 per share.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The following assumptions were used to compute the
fair value of warrants granted during the three months ended February 29, 2020:<B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 80%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 8pt Calibri,sans-serif">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 8pt; font-weight: bold; text-align: center">For the Three Months<BR>
 ended</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 8pt Calibri,sans-serif">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 8pt; font-weight: bold; text-align: center">February 29, 2020</TD><TD STYLE="padding-bottom: 1pt; font-size: 8pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 78%; padding-left: 5.4pt">Strike price</TD><TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 18%; text-align: right">2.12</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Term (years)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.0</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-left: 5.4pt">Volatility</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">120%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Risk-free rate</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.4%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Dividend yield</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.0%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><U>Modification of Warrants</U></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">On February 12, 2020, the Company modified an aggregated
of 245,625 warrants (the &ldquo;Warrants&rdquo;) that were originally granted to&nbsp;certain investors and consultants. The exercise
price of the Warrants was reduced to $2.33 per share and the term of the Warrants were extended for 2 years from the original maturity
date.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The Company received $20,000 cash from one of the investors
as consideration for this modification. The Company immediately recognized approximately $0.1 million incremental stock-based compensation
on February 12, 2020 based on the following weighted average assumptions:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 80%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 8pt Calibri,sans-serif">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 8pt; font-weight: bold; text-align: center">After Modification</TD><TD STYLE="padding-bottom: 1pt; font-size: 8pt; font-weight: bold">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-size: 8pt; font-weight: bold; text-align: center">Before Modification</TD><TD STYLE="padding-bottom: 1pt; font-size: 8pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 64%; padding-left: 5.4pt">Strike price</TD><TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 14%; text-align: right">2.33</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 14%; text-align: right">4.40</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Term (years)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.1</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2.1</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="padding-left: 5.4pt">Volatility</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">122%</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">155%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Risk-free rate</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.4%</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.5%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; padding-left: 5.4pt">Dividend yield</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.0%</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.0%</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: center"><B>Notes to Condensed Consolidated Financial Statements</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><I>Options Issued for Services</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The following represents a summary of all outstanding
options to purchase the Company&rsquo;s common stock at February 29, 2020 and the changes during the period then ended:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="font: 11pt Calibri, Helvetica, Sans-Serif; border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-family: Times New Roman,serif; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif; font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">Weighted
    Average</FONT></TD><TD STYLE="font-family: Times New Roman,serif; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-family: Times New Roman,serif; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif; font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">Weighted
    Average</FONT></TD><TD STYLE="font-family: Times New Roman,serif; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-family: Times New Roman,serif; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif; font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">Remaining
    <BR> Contractual</FONT></TD><TD STYLE="font-family: Times New Roman,serif; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: center"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-family: Times New Roman,serif; font-weight: bold; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-family: Times New Roman,serif; font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">Options</FONT></TD><TD STYLE="padding-bottom: 1pt; font-family: Times New Roman,serif; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-family: Times New Roman,serif; font-weight: bold; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-family: Times New Roman,serif; font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">Exercise
    Price</FONT></TD><TD STYLE="padding-bottom: 1pt; font-family: Times New Roman,serif; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-family: Times New Roman,serif; font-weight: bold; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-family: Times New Roman,serif; font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">Life
    (years)</FONT></TD><TD STYLE="padding-bottom: 1pt; font-family: Times New Roman,serif; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD><TD STYLE="font-family: Times New Roman,serif; font-weight: bold; padding-bottom: 1pt"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; font-family: Times New Roman,serif; font-weight: bold; text-align: center"><FONT STYLE="font-size: 8pt">Intrinsic
    Value</FONT></TD><TD STYLE="padding-bottom: 1pt; font-family: Times New Roman,serif; font-weight: bold"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; width: 35%; text-align: left"><FONT STYLE="font: 10pt Times New Roman,serif">Outstanding at December 1, 2019</FONT></TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 12%; text-align: right">1,200,000</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 12%; text-align: right">1.35</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 12%; text-align: right">3.4</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 2%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">$</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 12%; text-align: right">453,000</TD><TD STYLE="font: 10pt Times New Roman,serif; width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font: 10pt Times New Roman,serif">Issued</FONT></TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">150,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">1.50</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">4.8</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; text-align: right">&mdash;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left"><FONT STYLE="font: 10pt Times New Roman,serif">Outstanding at February 29, 2020</FONT></TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">1,350,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">1.37</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">3.3</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">1,965,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left"><FONT STYLE="font: 10pt Times New Roman,serif">Exercisable at February 29, 2020</FONT></TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">1,230,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">1.35</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">3.2</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.5pt double; font: 10pt Times New Roman,serif; text-align: right">1,810,000</TD><TD STYLE="font: 10pt Times New Roman,serif; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0"><I>Stock-based Compensation</I></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">The Company recognized general and administrative expenses
of approximately $4.5 million and $0.16 million as a result of the shares, outstanding warrants and options issued to consultants
and employees during the three months ended February 29, 2020 and February 28, 2019, respectively.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">As of February 29, 2020, the estimated unrecognized
stock-based compensation associate with these agreements is approximately $0.12 million and will be fully recognized over the next
12 months.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>Note 10 &ndash; Subsequent events</B></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><U>Amendments to Articles of Incorporation or Bylaws</U></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify; background-color: white">On April 3, 2020, the Company&rsquo;s
Board of Directors authorized the creation of up to 500,000 shares of Class A Convertible Preferred Stock (the &ldquo;Class A Preferred
Shares&rdquo;) and up to 1,000,000 shares of Class B Convertible Preferred Stock (the &ldquo;Class B Preferred Shares&rdquo;).
On April 6, 2020, the Company filed a Certificate of Designations with the Secretary of Nevada creating such Class A and Class
B Preferred Shares</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><U>Financing Agreements</U></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">On April 6, 2020, the Company entered into a securities
purchase agreement (the &ldquo;SPA&rdquo;) with accredited investors (the &ldquo;Investors&rdquo;). Pursuant to the SPA, the Investors
agreed to purchase:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 11pt Cambria,serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font: 10pt Times New Roman,serif">&bull;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman,serif">76,566 shares of Series A Convertible
Preferred Stock (the &ldquo;Series A Preferred Shares&rdquo;) in exchange for convertible debentures with principal and interest
of $765,656</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 11pt Cambria,serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font: 10pt Times New Roman,serif">&bull;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman,serif">100,000 Series A Preferred Shares
for cash of $1,000,000,</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 11pt Cambria,serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font: 10pt Times New Roman,serif">&bull;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman,serif">203,134 shares of Series B Convertible
Preferred Stock (&lsquo;the &ldquo;Series B Preferred Shares&rdquo;) in exchange for convertible debentures with principal and
interest of $2,031,342</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 11pt Cambria,serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font: 10pt Times New Roman,serif">&bull;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman,serif">100,000 Series B Preferred Shares
for cash of $1,000,000 and </FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 0.5in; text-align: justify; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 11pt Cambria,serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font: 10pt Times New Roman,serif">&bull;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman,serif">on April 17, 2020, 200,000 Series
B Preferred Shares for $2,000,000 in cash. </FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; background-color: white">By April 17, 2020, the Investors have the right
to convert all remaining unconverted debt into 51,432 Series A Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><U>Debt Conversion</U></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify">In March 2020, the Company converted approximately
$1.2 million outstanding debt and interest into 1,110,497 shares of common stock.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-align: justify"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PROSPECTUS</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Q BIOMED INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>1,836,286 Shares of Common Stock</B>&nbsp;<B>underlying
Series A Preferred Shares</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>3,163,714 Shares of Common Stock underlying
Series A Preferred Shares </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>[[&diams;]&nbsp;[&diams;],&nbsp;2020]</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Until [[&diams;], 2020] (the 90th day
after the date of this prospectus), all dealers that buy, sell or trade our common stock, whether or not participating in this
offering, may be required to deliver a prospectus. This delivery requirement is in addition to the dealers&rsquo; obligation to
deliver a prospectus when acting as underwriters and with respect to unsold allotments or subscriptions.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>No dealer, salesperson or other individual
has been authorized to give any information or to make any representations not contained in this prospectus in connection with
the offering covered by this prospectus. If given or made, such information or representations must not be relied upon as having
been authorized by us. This prospectus does not constitute an offer to sell, or a solicitation of an offer to buy the offered securities
in any jurisdiction where, or to any person to whom, it is unlawful to make any such offer or solicitation. Neither the delivery
of this prospectus nor any offer or sale made hereunder shall, under any circumstances, create an implication that there has not
been any change in the facts set forth in this prospectus or in our affairs since the date hereof.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.1pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION NOT REQUIRED IN THE PROSPECTUS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0in; text-align: justify"><FONT STYLE="font-size: 10pt"><B>ITEM
13. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.</B></FONT></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The table below itemizes the expenses payable
by the registrant in connection with the registration and issuance of the securities being registered hereunder, other than underwriting
discounts and commissions. All amounts except the Securities and Exchange Commission registration fee are estimated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 87%"><FONT STYLE="font-size: 10pt">Securities and Exchange Commission Registration Fee</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 10%; text-align: right"><FONT STYLE="font-size: 10pt">1,320</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD><FONT STYLE="font-size: 10pt">Legal Fees and Expenses</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">20,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD><FONT STYLE="font-size: 10pt">Accountants&rsquo; Fees and Expenses</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">5,000</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD><FONT STYLE="font-size: 10pt">Total</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">26,320</FONT></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0in; text-align: justify"><FONT STYLE="font-size: 10pt"><B>ITEM
14. INDEMNIFICATION OF DIRECTORS AND OFFICERS.</B></FONT></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Our officers and directors are indemnified
under Nevada law. Our Amended and Restated Articles of Incorporation and our Bylaws are silent as to director and officer indemnification
other than to allow such indemnification to the greatest extent permitted by Nevada law.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Nevada Revised Statute. The registrant
is a Nevada corporation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Section 78.138 of the Nevada Revised Statutes
provides that a director or officer will not be personally liable to the corporation and its stockholders unless it is proven that
(i) the director's or officer's acts or omissions constituted a breach of his fiduciary duties, and (ii) such breach involved intentional
misconduct, fraud or a knowing violation of the law. The provisions of the Nevada Revised Statutes with respect to limiting personal
liability for directors and officers are self-executing and, to the extent the provisions of our Amended and Restated Articles
of Incorporation and By-laws would be deemed to be inconsistent therewith, the provisions of the Nevada Revised Statutes will control.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Section&nbsp;78.7502 of the Nevada Revised
Statutes permits a corporation to indemnify a present or former director, officer, employee or agent of the corporation, or of
another entity or enterprise for which such person is or was serving in such capacity at the request of the corporation, who was
or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, except an
action by or in the right of the corporation, against expenses, including attorneys&rsquo; fees, judgments, fines and amounts paid
in settlement actually and reasonably incurred in connection therewith, arising by reason of such person&rsquo;s service in such
capacity if such person (i)&nbsp;is not liable pursuant to Section&nbsp;78.138 of the Nevada Revised Statutes, or (ii)&nbsp;acted
in good faith and in a manner which he or she reasonably believed to be in or not opposed to the best interests of the corporation
and, with respect to a criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful. In the
case of actions brought by or in the right of the corporation, however, no indemnification may be made for any claim, issue or
matter as to which such person has been adjudged by a court of competent jurisdiction, after exhaustion of all appeals therefrom,
to be liable to the corporation or for amounts paid in settlement to the corporation, unless and only to the extent that the court
in which the action or suit was brought or other court of competent jurisdiction determines upon application that in view of all
the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses as the court deems
proper.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Section&nbsp;78.751 of the Nevada Revised
Statutes permits any discretionary indemnification under Section&nbsp;78.7502 of the Nevada Revised Statutes, unless ordered by
a court or advanced to a director or officer by the corporation in accordance with the Nevada Revised Statutes, to be made by a
corporation only as authorized in each specific case upon a determination that indemnification of the director, officer, employee
or agent is proper in the circumstances. Such determination must be made (1)&nbsp;by the stockholders, (2)&nbsp;by the board of
directors by majority vote of a quorum consisting of directors who were not parties to the action, suit or proceeding, (3)&nbsp;if
a majority vote of a quorum consisting of directors who were not parties to the action, suit or proceeding so orders, by independent
legal counsel in a written opinion, or (4)&nbsp;if a quorum consisting of directors who were not parties to the action, suit or
proceeding cannot be obtained, by independent legal counsel in a written opinion.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0in; text-align: justify"><FONT STYLE="font-size: 10pt"><B>ITEM
15. SALES OF UNREGISTERED SECURITIES IN PAST THREE YEARS.</B></FONT></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On June 5, 2017, we issued warrants to
purchase up to 350,000 shares of our common stock to each of Denis Corin, our President and Chief Executive Officer, and William
Rosenstadt, our Chief Legal Officer. The warrants were issued as a bonus for their business development services to the Company
over the last 12 months. The warrants, as amended in September 2019, are exercisable for five years at a per share price of $1.25.
The warrants may not be exercised within the first six months of their issuance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On June 5, 2017, we issued warrants to
purchase up to 150,000 shares of our common stock to each of Ari Jatwes and David Laskow Pooley as a bonus for their business development
services to the Company over the last 12 months. The warrants are exercisable for five years at a per share price of $4.00. The
warrants may not be exercised within the first six months of their issuance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On June 5, 2017, we issued options to purchase
up to 150,000 shares of our common stock to each of Denis Corin, our President and Chief Executive Officer, and William Rosenstadt,
our Chief Legal Officer. 50,000 of the options were issued as compensation for their continued services on our board of directors
through June 1, 2018 and 100,000 of the options were issued as compensation as officers through June 1, 2018. 37,500 of the options
vest on September 1, 2017, 37,500 of the options vest on December 1, 2017, 37,500 of the options vest on March 1, 2018 and 37,500
of the options vest on June 1, 2018. The options, as amended in September 2019, are exercisable for five years at a per share price
of $1.25. The options may not be exercised within the first six months of vesting.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On June 5, 2017, we issued warrants to
purchase up to 25,000 shares of our common stock to a consultant as a bonus for their business development services to the Company
over the last 12 months. The warrants are exercisable for five years at a per share price of $4.00. The warrants may not be exercised
within the first six months of their issuance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On June 5, 2017, we issued warrants to
purchase up to 10,000 shares of our common stock to a consultant as a bonus for accounting services to the Company over the last
12 months. The warrants are exercisable for five years at a per share price of $4.00. The warrants may not be exercised within
the first six months of their issuance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On August 1, 2017, we issued 953,249 units
in exchange for $3,050,390, which included payment through the retirement of $518,400 of outstanding debt.&nbsp; Each unit consisted
of two shares of our common stock and a warrant to purchase a share of our common stock at $4.50. We also issued 39,246 warrants
to the placement agents in the August 1, 2017 transaction pursuant to the placement agents agreement to which the placement agents
and we are parties.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On October 3, 2017, we issued 25,641 restricted
shares of our common stock to the holder of the Debentures as consideration for extending the maturity date of the Debentures from
November 30, 2017 to November 30, 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In September and October 2017, we issued
an aggregate of 31,000 shares of its common stock to our vendors for services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On October 16, 2017, we issued 146,662
shares of our common stock to the holder of a convertible notes issued on March 10, 2017 upon the conversion of $500,445 of principal
and interest of such note.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 2, 2017, the Company issued
46,875 shares of its common stock in full settlement of $150,000 in principal and interest due to an entity as a result of promissory
notes issued by it in November 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 22, 2017, we issued 166,592
shares of our common stock to the holder of a convertible notes issued on November 29, 2016 and March 10, 2017 upon the conversion
of $551,771 of principal and interest of such notes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 23, 2017, we issued 13,200
shares of our common stock to an investor upon its conversion of $30,000 in principal in, and $3,000 in interest on, a convertible
note purchased from us on November 22, 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 29, 2017, we issued 270,270
shares of our common stock to the holder of a convertible notes issued on November 29, 2016 upon the conversion of $1,000,000 of
principal of such note and the waiver and release of any other amounts or obligations, including interest, due under such note,
a convertible note issued on March 10, 2017 and a convertible note issued on April 7, 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On February 13, 2018, we issued options
to acquire up to 50,000 shares of our common stock to our independent director. The options will vest in quarterly installments
of 12,500 each and are exercisable for 5 years at $3.00 per option.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On March 1, 2018, we issued 27,000 shares
to a third-party service provider in exchange for services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On June 1, 2018, we issued 50,000 options
to each of Denis Corin and William Rosenstadt for their continued services as directors of our company. Each option is to purchase
a share of our common stock for $1.25 per share, as amended in September 2019. The options vest in quarterly amounts on May 31,
2018, September 1, 2018, December 1, 2018 and March 1, 2019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On June 1, 2018, we issued 100,000 options
to each of Denis Corin and William Rosenstadt for their continued services as officers of our company. Each option is to purchase
a share of our common stock for $1.25 per share, as amended in September 2019. The options vest in quarterly amounts on May 31,
2018, September 1, 2018, December 1, 2018 and March 1, 2019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On June 1, 2018, we entered into a new
agreement with a consultant to provide expertise in the areas of technology assessment and product development. In exchange for
such services, the consultant will receive warrants to purchase a share of our common stock exercisable at $3.61 per share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In June 2018, we entered into an agreement
with a consultant to provide expertise in the areas of commercial marketing. In exchange for such services, each month for the
twelve months of the agreement the consultant will receive shares of our common stock equal to $22,000 divided by the market price
of our common stock on the first day of such month.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On July 9, 2018, we issued options to purchase
50,000 shares of our common stock at $3.61 per option to each of two advisors in exchange for consulting services. The options
vest in quarterly amounts every three months.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On September 21, 2018, we issued a convertible
note in the face amount of $2,000,000 which bears interest at 5.5% per annum. The convertible note may be converted into shares
of our common stock at&nbsp;<FONT STYLE="background-color: white">the lesser of (i) $4.00 and (ii) 93%&nbsp;</FONT>of the four
lowest daily volume weighted average prices of the Company&rsquo;s common stock (as reported by Bloomberg) during the last ten
trading days immediately preceding the date of such conversion<FONT STYLE="background-color: white">, but in no event will the
conversion price be less than $2.00.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On September 21, 2018, we issued 25,000
shares in connection with the waiver of a right of first refusal for the sale of the September 2018 convertible debentures mentioned
above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On September 21, 2018, we issued 25,000
shares for advisory services in connection with the sale of the September 2018 convertible debentures mentioned above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On September 21, 2018, we issued 25,000
shares in connection with legal services provided to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On September 21, 2018, we issued 38,049
shares of common stock to four consultants, including a member of our board and two members of our board of advisors, for consulting
services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In October 2018, we issued 50,000 shares
to BNI in compliance with our license agreement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In November 2018, we issued 49,875 shares
to our consultants in exchange for consulting services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 1, 2018, we issued a convertible
note in the face amount of $2,000,000 which bears interest at 5.5% per annum. The convertible note, as amended on September 23,
2019, may be converted into shares of our common stock at&nbsp;<FONT STYLE="background-color: white">the lesser of (i) $1.00 and
(ii) 93%&nbsp;</FONT>of the four lowest daily volume weighted average prices of the Company&rsquo;s common stock (as reported by
Bloomberg) during the last ten trading days immediately preceding the date of such conversion<FONT STYLE="background-color: white">,
but in no event will the conversion price be less than $0.50, or (</FONT>iii) a price agreed to by us and the investor<FONT STYLE="background-color: white">.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">On January 4, 2019, we issued an aggregate of 175,919 shares
of the Company common stock to various vendors for advisory services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On April 9, 2019, we issued an aggregate
of 185,128 shares of the Company&rsquo;s common stock to various vendors for advisory services and the extension of the Mannin
Purchase Option Agreement.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">On March 26, 2019, we entered into an amendment to the Patent
and Technology License and Purchase Option Agreement that it initially entered into with Mannin Research Inc. on October 29, 2015.
Pursuant to such amendment, the Company issued 100,000 shares to Mannin Research Inc. in exchange for the term of the option granted
under the agreement extending to October 29, 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In March 2019, we issued an aggregate of 386,900 shares of the
Company&rsquo;s common stock to various vendors for advisory services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On August 28, 2019, we issued a convertible
debenture in the face amount of $550,000 which bears interest at 10% per annum. The debenture is convertible at any time at the
conversion price of $2.50 per share. At any time that is six months after the issuance, a portion of the Debenture is redeemable,
not to exceed $150,000 in any month. We may pay such a redemption in cash and/or shares of common stock. Any payment of such a
redemption in shares of common stock shall be made at the lesser of $2.50 or 93% of the average of the four lowest VWAPs in the
prior ten trading day, provided that no such conversion price shall be less than $2.00. Any payment of such a redemption in cash
shall be at 120% of the amount being redeemed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="background-color: white">On
August 13, 2019, we issued 365,450 shares of our common stock to the holder of a convertible note issued on September 21, 2018
upon conversion of $326,164 of principal and interest of such note.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">On September 23, 2019, we issued 50,000
shares of our common stock to BioNucleonics, Inc. pursuant to a settlement agreement dated September 23, 2019.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="background-color: white">On
September 24, 2019, we issued 667,095 shares of our common stock to the holder of a convertible note issued on November 1, 2018
upon conversion of $333.547.95 of principal and interest of such note.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="background-color: white">On
September 24, 2019, we issued warrants to purchase 50,000 shares of our common stock to Ari Jatwes for services as a consultant.
The warrants are exercisable for a term of 5 years from the date of issuance at a price of $1.25 per share.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="background-color: white">On
September 24, 2019, we issued warrants to purchase 50,000 shares of our common stock to Riccardo Panicucci for services as a director.
The warrants are exercisable for a term of 5 years from the date of issuance at a price of $1.25 per share.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="background-color: white">On
September 24, 2019, we issued warrants to purchase 84,000 shares of our common stock to Access! Association for business development
services pursuant to a consulting agreement. The warrants are exercisable for a term of 3 years from the date of issuance at a
price of $1.25 per share.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="background-color: white">On
September 24, 2019, we issued warrants to purchase 100,000 shares of our common stock to Rajendra Apte for business development
services as a consultant. The warrants are vested in equal portions quarterly (12,500 warrants per quarter) and are exercisable
for a term of 5 years from the date of issuance at a price of $1.25 per share.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In September 2019, we issued additional
201,157 units (and the corresponding underlying securities) to various investors who had purchased $180,750 of units, each unit
consisting of one share of common stock and one warrant to purchase a share of common stock, at $2.00 per unit in May 2019. Pursuant
to these amendments, the unit purchase price was reduced to $0.62 and the exercise price of warrants in the units was reduced to
$0.86.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In September 2019, we entered into a series
of related Securities Purchase Agreements with seven investors for a total of $208,250. Pursuant to the terms of the investment,
such investors received 335,887 shares of our common stock and 503,831 warrants to purchase shares of our common stock at an exercise
price of $0.86.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On October 7, we issued 496,109 shares
of common stock upon the conversion of $198,443.84 of principal and interest of a convertible note issued by us in September 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">On October 11,
2019, we issued a convertible debenture in the face amount of $500,000 which bears interest at 5.5% per annum. The convertible
debenture may be converted into shares of our common stock at&nbsp;<FONT STYLE="background-color: white">the lesser of </FONT>$1.00
or 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately preceding the conversion
date, provided that as long as we are not in default under the Debenture, the conversion price may never be less than $0.50.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In October 2019, we issued 148,261 units
(with each unit consisting of one share of common stock and 1.5 warrants to purchase a share of common stock) to our legal counsel
in exchange for $91,922 of services provided. Our Chief Legal Officer and a Director is the Managing Partner at the law firm where
these services were provided.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In October and November 2019, we entered
into a series of securities purchase agreements for the sale of 1,185,715 units at a $0.35 per unit sales price. Each unit consisted
of one share and one warrant to purchase a share of common stock at an exercise price of $0.50.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In November 2019, we converted $20,000
of outstanding debt due to one of our directors into 40,000 shares of common stock and $20,000 of outstanding debt due to a consultant
into 40,000 shares of common stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 20, 2019, we issued 831,481
shares to a note holder in exchange for the conversion of $415,740.82 of principal and interest on convertible notes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 25, 2019, we issued 500 shares
to a director in exchange for services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 25, 2019, we issued 254,442
shares to five consultants pursuant to consulting agreements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 25, 2019, we issued 377,834
shares pursuant to a research collaboration and master services agreement with Chemveda Life Sciences India Private Limited.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On November 25, 2019, we issued 150,000
shares due to BioNucleonics, Inc. pursuant to a September 23, 2019 Settlement Agreement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On December 2, 2019, we issued 503,295
shares to a note holder in exchange for the conversion of $251,674.74 of principal and interest on convertible notes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On December 5, 2019, we issued 150,000
options to Ricardo Panicucci for his continued services as a director of our company. Each option is to purchase a share of our
common stock for $1.50 per share. One-fifth of the options vested immediately and an additional fifth vests each quarter thereafter.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">On December 6,
2019, we issued a convertible debenture in the face amount of $1,000,000 which bears interest at 5.5% per annum. The convertible
debenture may be converted into shares of our common stock at&nbsp;<FONT STYLE="background-color: white">the lesser of</FONT> $3.00
or 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately preceding the conversion
date, provided that the conversion price may never be less than $2.00.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On December 31, 2019, we issued 204,653
shares of common stock to a note holder in exchange for the conversion of $204,653.15 of principal and interest on convertible
notes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">On January 15,
2020, we issued a convertible debenture in the face amount of $1,000,000 which bears interest at 5.5% per annum. The convertible
debenture may be converted into shares of our common stock at&nbsp;<FONT STYLE="background-color: white">the lesser of </FONT>$3.00
or 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately preceding the conversion
date, provided that the conversion price may never be less than $2.00.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">On January 31, 2020, we issued 378,573 shares to a note holder
in exchange for the conversion of $378,573.49 of principal and interest on convertible notes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On February 10, 2020, we issued 885,000
warrants to 11 consultants and service providers in exchange for services rendered. The warrants are exercisable into shares of
the Company&rsquo;s common stock for five years from the date of issuance at an exercise price of $2.12 per share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On February 10, 2020, we issued 1,500,000
warrants to two officers in exchange for services rendered. The warrants are exercisable into shares of the Company&rsquo;s common
stock in six months from their issuance until five years from the date of issuance at an exercise price of $2.12 per share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On February 28, 2020, we issued 391,645
shares to a note holder in exchange for the conversion of $391,645.48 of principal and interest on convertible notes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">On March 31, 2020, we issued 1,050,496
shares to a note holder in exchange for the conversion of $1,050,496.78 of principal and interest on convertible notes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On April 6, 2020, we issued 176,566 shares
of Series A Convertible Preferred Stock and 303,134 shares of Series B Convertible Preferred Stock to the holder of convertible
notes in exchange for conversion of $2,796,999 of principal and interest on convertible notes and cash of $2,000,000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On April 7, 2020, we issued 250,000 warrants
in exchange for legal services, which warrants are exercisable for five years into 250,000 shares of common stock at an exercise
price of $2.12 per share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On April 17, 2020, we issued 200,000 shares
of Series B Convertible Preferred Stock in exchange for cash of $2,000,000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">The issuances
of the securities mentioned above qualified for the exemption from registration contained in Section 4(2) of the Securities Act
of 1933.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0in; text-align: justify"><FONT STYLE="font-size: 10pt"><B>ITEM
16. EXHIBITS.</B></FONT></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%"><FONT STYLE="font-size: 10pt"><B>Exhibit</B></FONT></TD>
    <TD STYLE="width: 95%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt"><B>No.</B></FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000139390514000018/ismo_ex3a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">3.1&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000139390514000018/ismo_ex3a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Articles of Incorporation filed as Exhibit 3 (a) to Form S-1 filed on January 13, 2014&nbsp;and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488415000112/exhibit3-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">3.2&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488415000112/exhibit3-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Amendment to Articles of&nbsp;Incorporation, dated July 20, 2015, filed as Exhibit 3.1 to our periodic report filed on Form 8-K on August 3, 2015 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488415000159/exhibit.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">3.3&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488415000159/exhibit.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Amendment to Articles of Incorporation, dated October 27, 2015, filed as Exhibit 3.1 to our periodic report filed on Form 8-K on October 29, 2015 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000139390514000018/ismo_ex3a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">3.4&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000139390514000018/ismo_ex3a.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Articles of Incorporation filed as Exhibit 3 (b) to Form S-1 filed on January 13, 2014&nbsp;and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465920044005/tm2015201d1_ex3-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">3.5 </FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465920044005/tm2015201d1_ex3-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Certificate of Designation for Series A Convertible Preferred Stock, dated April 6, 2020, filed as Exhibit 3.1 to our Form 8-K on April 7, 2020 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465920044005/tm2015201d1_ex3-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">3.6 </FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465920044005/tm2015201d1_ex3-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Certificate of Designation for Series B Convertible Preferred Stock, dated April 6, 2020, filed as Exhibit 3.2 to our Form 8-K on April 7, 2020 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000165495418000280/warrant.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">4.1&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000165495418000280/warrant.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Warrant in connection with our February 1, 2018 offering filed as Exhibit 4.1 to our registration statement on Form S-1 filed on January 12, 2018</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000121390017006273/f8k052417ex4ii_qbiomedinc.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">4.2</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000121390017006273/f8k052417ex4ii_qbiomedinc.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Warrant as filed as Exhibit 4.2 to our current report on Form 8-K filed on June 9, 2017 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488417000063/warrant.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">4.3</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488417000063/warrant.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Warrant as filed as Exhibit 10.3 to our current report on Form 8-K filed on August 2, 2017 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="tm2016832d1_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">5.1</FONT></A></TD>
    <TD><A HREF="tm2016832d1_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Opinion of Ortoli Rosenstadt LLP*</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.1&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Non-Institutional Promissory Note filed as Exhibit 10.1 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.2&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Stock Purchase Agreement for Institutional Promissory Note, dated January 8, 2016, with CMGT filed as Exhibit 10.2 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-4.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.3&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-4.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Institutional Promissory Note filed as Exhibit 10.4 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-5.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.4&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-5.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Advisory Agreement, dated September 8, 2015, with Wombat Capital Ltd. filed as Exhibit 10.5 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-6.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.5&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-6.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Advisory Agreement, dated June 1, 2015, with Ari Jatwes&nbsp;filed as Exhibit 10.6 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-7.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.6&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000192/exhibit10-7.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Consulting Agreement, dated November 13, 2015, Pharmafor Ltd. filed as Exhibit 10.7 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000121390017006273/f8k052417ex10i_qbiomedinc.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.7&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000121390017006273/f8k052417ex10i_qbiomedinc.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Executive Services Agreement, dates June 1, 2017, between Denis Corin and Q BioMed Cayman SEZC filed as Exhibit 10.1 to our current report on Form 8-K filed on June 9, 2017 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000121390017006273/f8k052417ex4i_qbiomedinc.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.9&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000121390017006273/f8k052417ex4i_qbiomedinc.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Non-Qualified Stock Option Agreement filed as Exhibit 4.1 to our current report on Form 8-K filed on June 9, 2017 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000214/exhibit10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.10&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000214/exhibit10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Patent and Technology License and Purchase Option Agreement, dated October 29, 2015, with Mannin Research Inc.&nbsp;filed as Exhibit 10.1 to our annual report on Form 10-K filed on March 11, 2016 and incorporated herein by reference +</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000254/exhibit10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.11</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000254/exhibit10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Patent and Technology License and Purchase Option Agreement, dated May 30, 2016, with Bio-Nucleonics Inc., filed as Exhibit 10.1 to our quarterly report on Form 10-Q filed on October 17, 2016 and incorporated herein by reference&nbsp;+</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000254/exhibit10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.12</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488416000254/exhibit10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">First Amendment to Patent and Technology License and Purchase Option Agreement, dated September 6, 2016, with Bio-Nucleonics Inc., filed as Exhibit 10.2 to our quarterly report on Form 10-Q filed on October 17, 2016 and incorporated herein by reference&nbsp;+</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488417000032/ex_10_1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.13</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488417000032/ex_10_1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">License Agreement on Patent &amp; Know-How Technology, dated April 21, 2017, between Q BioMed Inc. and ASDERA LLC filed as Exhibit 10.1 to our quarterly report on Form 10-Q filed on April 25, 2017 and incorporated herein by reference&nbsp;+</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000121390017006273/f8k052417ex10i_qbiomedinc.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.14</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000121390017006273/f8k052417ex10i_qbiomedinc.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Executive Services Agreement, dated June 5, 2017, between Q BioMed Cayman SEZC and Denis Corin filed as Exhibit 10.1 to our current report on Form 8-K filed on June 9, 2017 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488417000044/ex_10_1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.15</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000142488417000044/ex_10_1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Technology License Agreement, dated June 15, 2017, among Q BioMed Inc., Oklahoma Medical Research Foundation and Rajiv Gandhi Centre for BioTechnology filed as Exhibit 10.1 to our current report on Form 8-K filed on June 15, 2017 and incorporated herein by reference&nbsp;+</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000165495418000334/paa.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.16&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000165495418000334/paa.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Placement Agent Agreement in connection with our February 1, 2018 offering filed as Exhibit 10.15 to our registration statement on Form S-1 filed on January 12, 2018</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000165495418000334/spa.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.17&nbsp;</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000165495418000334/spa.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Securities Purchase Agreement in connection with our February 1, 2018 offering filed as Exhibit 10.16 to our registration statement on Form S-1 filed on January 12, 2018</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000114420418050539/tv503372_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.18</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000114420418050539/tv503372_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Securities Purchase Agreement, dated September 21, 2018,&nbsp;filed as Exhibit 10.1 to our current report on Form 8-K filed on September 24, 2018 and incorporated herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000114420418062024/tv508085_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.19</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000114420418062024/tv508085_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Asset Purchase Agreement with GE Healthcare Limited, dated November 23, 2018, filed as Exhibit 10.1 to our current report on Form 8-K filed on November 28, 2018 and incorporated herein by reference++</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000114420419043746/tv529017_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.20</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000114420419043746/tv529017_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Securities Purchase Agreement, dated August 28, 2019, filed as Exhibit 10.1 to our current report on Form 8-K (as amended) on September 6, 2019 and incorporate herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000114420419043746/tv529017_ex10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.21</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000114420419043746/tv529017_ex10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Debenture pursuant to the Securities Purchase Agreement entered into on August 28, 2019, filed as Exhibit 10.2 to our current report on Form 8-K (as amended) on September 6, 2019 and incorporate herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465919053945/tv531033_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.22</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465919053945/tv531033_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Securities Purchase Agreement, dated October 11, 2019, filed as Exhibit 10.1 to our current report on Form 8-K on October 15, 2019 and incorporate herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465919053945/tv531033_ex10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.23</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465919053945/tv531033_ex10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Debenture pursuant to the Securities Purchase Agreement entered into on October 11, 2019, filed as Exhibit 10.2 to our current report on Form 8-K on October 15, 2019 and incorporate herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465919072215/tm1925000d1_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.24</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465919072215/tm1925000d1_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Securities Purchase Agreement, dated December 5, 2019, filed as Exhibit 10.1 to our current report on Form 8-K on December 12, 2019 and incorporate herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465919072215/tm1925000d1_ex10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.25</FONT></A></TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465919072215/tm1925000d1_ex10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Form of Debenture pursuant to the Securities Purchase Agreement entered into on December 5, 2019, filed as Exhibit 10.2 to our current report on Form 8-K on December 12, 2019 and incorporate herein by reference</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465920044005/tm2015201d1_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.26</FONT></A></TD>
    <TD STYLE="text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465920044005/tm2015201d1_ex10-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Securities Purchase Agreement in connection with our April 6, 2020 private placement of Preferred Shares filed as Exhibit 10.1 to our current report on Form 8-k filed on April 7, 2020</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465920044005/tm2015201d1_ex10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.27</FONT></A></TD>
    <TD STYLE="text-align: justify"><A HREF="http://www.sec.gov/Archives/edgar/data/1596062/000110465920044005/tm2015201d1_ex10-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Registration Rights Agreement filed as Exhibit 10.2 to our current report on Form 8-k filed on April 7, 2020</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify"><A HREF="tm2016832d1_ex21-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">21.1</FONT></A></TD>
    <TD STYLE="text-align: justify"><A HREF="tm2016832d1_ex21-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">List of Subsidiaries*</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="tm2016832d1_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">23.1</FONT></A></TD>
    <TD><A HREF="tm2016832d1_ex5-1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Consent of Ortoli Rosenstadt (included in Exhibit 5.1)</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="tm2016832d1_ex23-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">23.2</FONT></A></TD>
    <TD><A HREF="tm2016832d1_ex23-2.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Consent of Marcum LLP*</FONT></A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><A HREF="#POA" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">24.1</FONT></A></TD>
    <TD><A HREF="#POA" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Power of Attorney (included on the signature page to this Registration Statement)</FONT></A></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">*Filed herewith</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">+&nbsp;Portions of this exhibit have been omitted pursuant to
a request for confidential treatment, and&nbsp;the SEC has granted confidential treatment pursuant to Rule 406 under the Securities
Act. Confidential information has been omitted from the exhibit in places marked &ldquo;****&rdquo;and has been filed separately
with the SEC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0in; text-align: justify"><FONT STYLE="font-size: 10pt"><B>ITEM
17. UNDERTAKINGS.</B></FONT></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 27pt">(a)</TD><TD STYLE="text-align: justify">RULE 415 OFFERING</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The undersigned registrant hereby undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(1)&nbsp;&nbsp;To file, during any period
in which offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">(i)</TD><TD STYLE="text-align: justify">To include any prospectus required by Section 10(a)(3)
of the Securities Act of 1933, as amended;</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: -27pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">(ii)</TD><TD STYLE="text-align: justify">To reflect in the prospectus any facts or events arising
after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually
or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding
the foregoing, any increase or decrease in the volume of securities offered (if the total dollar value of securities offered would
not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be
reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b)) if, in the aggregate, the changes in volume
and price represent no more than 20% change in the maximum aggregate offering price set forth in the &ldquo;Calculation of Registration
Fee&rdquo; table in the effective registration statement; and</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: -27pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left">(iii)</TD><TD STYLE="text-align: justify">To include any material information with respect to
the plan of distribution not previously disclosed in the registration statement or any material change to such information in
the registration statement;</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(2)&nbsp;&nbsp;That, for the purpose of
determining any liability under the Securities Act of 1933, as amended, each such post- effective amendment shall be deemed to
be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall
be deemed to be initial bona fide offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(3)&nbsp;&nbsp;To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(4)&nbsp;&nbsp;That, for the purpose of
determining liability under the Securities Act of 1933, as amended, to any purchaser:&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(A) Each prospectus filed by the registrant
pursuant to Rule 424(b)(3) shall be deemed to be part of the Registration Statement as of the date the filed prospectus was deemed
part of and included in the Registration Statement; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(B) Each prospectus required to be filed
pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a Registration Statement in reliance on Rule 430B relating to an offering
made pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by Section 10(a) of the
Securities Act of 1933, as amended, shall be deemed to be part of and included in the Registration Statement as of the earlier
of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities
in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that
is at that date an underwriter, such date shall be deemed to be a new effective date of the Registration Statement relating to
the securities in the Registration Statement to which that prospectus relates, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof. Provided, however, that no statement made in a Registration Statement
or prospectus that is part of the Registration Statement or made in a document incorporated or deemed incorporated by reference
into the Registration Statement or prospectus that is part of the Registration Statement will, as to the purchaser with a time
of contract of sale prior to such effective date, supersede or modify any statement that was made in the Registration Statement
or prospectus that was part of the Registration Statement or made in any such document immediately prior to such effective date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(5)&nbsp;&nbsp;That, for the purpose of
determining liability of the registrant under the Securities Act of 1933, as amended, to any purchaser in the initial distribution
of the securities, the undersigned registrant undertakes that in a primary offering of securities of the undersigned registrant
pursuant to this Registration Statement, regardless of the underwriting method used to sell the securities to the purchaser, if
the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned registrant
will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 20.25pt"></TD><TD STYLE="width: 27pt">(i)</TD><TD STYLE="text-align: justify">Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering
required to be filed pursuant to Rule 424;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 20.25pt"></TD><TD STYLE="width: 27pt">(ii)</TD><TD STYLE="text-align: justify">Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned
registrant or used or referred to by the undersigned registrant;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 20.25pt"></TD><TD STYLE="width: 27pt">(iii)</TD><TD STYLE="text-align: justify">The portion of any other free writing prospectuses relating to the offering containing material
information about the undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: -27pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 20.25pt"></TD><TD STYLE="width: 27pt">(iv)</TD><TD STYLE="text-align: justify">Any other communication that is an offer in the offering made by the undersigned registrant to
the purchaser.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">(h)&nbsp;&nbsp;Insofar as indemnification
for liabilities arising under the Securities Act of 1933, as amended, may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion
of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant
of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered,
the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court
of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities
Act of 1933, as amended, and will be governed by the final adjudication of such issue.<B>&nbsp;&nbsp;</B></P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the requirements of the Securities Act of 1933,
the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized,
on April 28, 2020.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3"><FONT STYLE="font-size: 10pt">Q BioMed Inc.</FONT></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 3%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 46%"><FONT STYLE="font-size: 10pt"><U>/s/ Denis Corin</U></FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Denis Corin</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Chief Executive Officer (Principal Executive Officer), Chief Financial Officer (Principal Accounting Officer)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><A NAME="POA"></A>Pursuant to the requirements of the Securities
Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates
indicated. Each person in so signing also makes, constitutes and appoints Denis Corin, his or her true and lawful attorney-in-fact,
with full power of substitution, in any and all capacities, to execute and cause to be filed with the Securities and Exchange Commission
pursuant to the requirements of the Securities Act of 1933, as amended, any and all amendments and post-effective amendments to
this Registration Statement, with exhibits to such registration statements and amendments and other documents in connection therewith,
and hereby ratifies and confirms all that said attorney-in-fact or his or her substitute or substitutes may do or cause to be done
by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 30%"><FONT STYLE="font-size: 10pt"><B>Signature</B></FONT></TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 30%"><FONT STYLE="font-size: 10pt"><B>Title</B></FONT></TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 30%"><FONT STYLE="font-size: 10pt"><B>Date</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="border-bottom: Black 1pt solid; vertical-align: top">/s/ William Rosenstadt</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">April 28, 2020</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">William Rosenstadt</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>

<TR>
    <TD STYLE="border-bottom: Black 1pt solid; vertical-align: top">/s/ Denis Corin</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">Director</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">April 28, 2020&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 30%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Denis Corin</P></TD>
    <TD STYLE="vertical-align: bottom; width: 5%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 30%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P></TD>
    <TD STYLE="vertical-align: bottom; width: 5%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 30%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="border-bottom: Black 1pt solid; vertical-align: top">/s/ Rick Panicucci</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Director</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">April 28, 2020</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Rick Panicucci&nbsp;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

































































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[{"type": "S-1", "sequence": "1", "filename": "tm2016832d1_s1.htm", "description": "FORM S-1", "secsgml_size_bytes": 1216953}]
{"company-data": {"conformed-name": "Q BioMed Inc.", "cik": "0001596062", "assigned-sic": "2834", "irs-number": "464013793", "state-of-incorporation": "NV", "fiscal-year-end": "1130"}, "filing-values": {"form-type": "S-1", "act": "33", "file-number": "333-237872", "film-number": "20825329"}, "business-address": {"street1": "366 MADISON AVE.", "street2": "3RD FLOOR", "city": "NEW YORK", "state": "NY", "zip": "10017", "phone": "212-588-0022"}, "mail-address": {"street1": "366 MADISON AVE.", "street2": "3RD FLOOR", "city": "NEW YORK", "state": "NY", "zip": "10017"}, "former-company": {"former-conformed-name": "ISMO Tech Solutions, Inc.", "date-changed": "20140107"}}
As filed with the Securities and Exchange
Commission on April 28, 2020
Registration No.
333-________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-1
REGISTRATION STATEMENT UNDER THE SECURITIES
ACT OF 1933
Q BIOMED
INC.
(Name of Issuer in Its Charter)
Nevada
(State or other jurisdiction
of incorporation)
2834
46-4013793
(Primary Standard Industrial Classification Code Number)
(IRS Employer Identification No.)
c/o Ortoli Rosenstadt LLP
366 Madison Avenue – 3rd Floor
New York, NY 10017
Telephone: 212-588-0022
Fax: 212-826-9307
(Address including zip code, and telephone
number, including area code, of registrant's principal executive offices)
Vcorp Services, LLC
701 S. Carson Street, Suite 200
Carson City NV 89701
(888) 528 2677
(Name, address, including zip code, and
telephone number, including area code, of agent for service)
Copies to:
William Rosenstadt, Esq.
Tim Dockery, Esq.
Ortoli Rosenstadt LLP
366 Madison Avenue, 3rd Floor
New York, New York, U.S.A., 10017
Telephone: (302) 738-6680
As soon as practicable after this
registration statement becomes effective.
Approximate date of commencement of proposed
sale to the public
If any of the securities being registered
on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the
following box:
x
If this Form is filed to register additional
securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities
Act registration statement number of the earlier effective registration statement for the same offering.
o
If this Form is a post-effective amendment
filed pursuant to Rule 462(c) under the Securities Act of 1933, check the following box and list the Securities Act registration
statement number of the earlier effective registration statement for the same offering.
o
If this Form is a post-effective amendment
filed pursuant to Rule 462(d) under the Securities Act of 1933, check the following box and list the Securities Act registration
statement number of the earlier effective registration statement for the same offering.
o
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2
of the Exchange Act. (Check one):
Large accelerated filer
o
Accelerated filer
o
Non-accelerated filer
x
Smaller reporting company
x
Emerging growth company
o
CALCULATION OF REGISTRATION FEE
Title of Each Class of Securities to Be Registered
Amount to Be
Registered (1)
Proposed
Maximum
Offering
Price
Per
Security (2)
Proposed
Maximum
Aggregate
Offering
Price (2)
Amount of
Registration
Fee
Shares of Common Stock Issuable upon Conversion of Series A Convertible Preferred Stock or Payments of Dividends Theron (3)
1,836,286
$
2.03
$
3,727,661
$
484
Shares of Common Stock Issuable upon Conversion of Series B Convertible Preferred Stock or Payments of Dividends Theron (4)
3,163,714
$
2.03
$
6,442,339
$
836
Total:
5,000,000
$
2.03
$
10,150,000
$
1,320
(1)
Pursuant to Rule 416, there are also being registered such additional securities as may be issued to prevent dilution resulting from stock splits, stock dividends, or similar transactions as a result of the anti-dilution provisions contained in the Series A Convertible Preferred Stock and the Series B Convertible Preferred Stock.
(2)
Estimated solely for the purpose of calculating the registration fee for this offering pursuant to Rule 457(c) under the Securities Act of 1933, as amended (the "Securities Act"), using the closing price on April 24, 2020 (a date within five days of the initial filing of this registration statement) of $2.03 as reported on the OTCQB.
(3)
Represents 1,836,286 shares of the Registrant's common stock being registered for resale that may be acquired upon the conversion of shares of Series A Convertible Preferred Stock or payments of dividends thereon.
(4)
Represents 3,163,714 shares of the Registrant's common stock being registered for resale that may be acquired upon conversion of shares of Series B Convertible Preferred Stock or payments of dividends thereon.
THE REGISTRANT HEREBY AMENDS THIS REGISTRATION
STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT
WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT
TO SAID SECTION 8(A), MAY DETERMINE.
The information in this
prospectus is not complete and may be changed. These securities may not be resold until the registration statement filed with the
Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities, and it is not soliciting
offers to buy these securities in any jurisdiction where the offer or sale is not permitted.
Subject to Completion—Dated
April 28, 2020
PROSPECTUS
1,836,286 Shares of Common Stock
underlying
shares of Series A Convertible Preferred Stock
3,163,714 Shares of Common
Stock
underlying shares of Series B Convertible Preferred Stock
This prospectus relates to the offer and
sale, from time to time, of up to 5,000,000 shares of common stock of Q BioMed Inc. (the "Company", "we",
 "us' and "our") by the stockholder named in the section of this prospectus entitled "Selling Stockholder".
We entered into a Securities Purchase Agreement with the selling stockholder on April 6, 2020 by which the selling stockholder
acquired 176,566 shares of Series A Convertible Preferred Stock (the "Series A Preferred Shares") convertible into
shares of our common stock, of which 1,836,286 shares of our common stock are being offered for resale pursuant to this prospectus
(together with shares of our common stock to be paid as dividends on the Series A Shares, the "Series A Conversion Shares"),
and 503,134 shares of Series B Convertible Preferred Stock (the "Series B Preferred Shares" and together with the Series
A Preferred Shares, the "Preferred Shares") convertible into shares of our common stock, of which 3,163,714 shares
of our common stock are being offered for resale pursuant to this prospectus (together with shares of our common stock to be paid
as dividends on the Series A Shares, the "Series B Conversion Shares" and together with the Series A Conversion Shares,
the "Conversion Shares").
We are not selling any shares of common
stock in this offering, and we will not receive any proceeds from the sale of the Conversion Shares by the selling stockholder.
Our common stock is quoted on the OTC Market
Group Inc.'s Venture Market (the "OTCQB") under the symbol "QBIO". On April 17, 2020, the last reported
sale price of our common stock on the OTCQB was $2.07 per share, and on April 17, 2020 we had 22,468,185 shares of common stock
outstanding.
The selling stockholder may offer all or
part of the Series A Conversion Shares and Series B Conversion Shares for resale from time-to-time through public or private transactions,
at either prevailing market prices or at privately negotiated prices.
This prospectus provides a general description
of the securities being offered. You should read this prospectus and the registration statement of which it forms a part before
you invest in any securities.
Investing in our securities involves
risks. You should review carefully the risks and uncertainties described under the heading "
Risk Factors
" on
page 1.
Neither the Securities and Exchange
Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus
is truthful or complete. Any representation to the contrary is a criminal offense.
The date of this prospectus is April __,
2020
Table of Contents
Page
Prospectus Summary
ii
Risk Factors
1
Use of Proceeds
16
Determination of Offering Price
17
Plan of Distribution
17
Description of Securities
19
The Purchase Agreement
23
Selling Stockholder
23
Business
27
Market For Registrant's Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
36
Management's Discussion and Analysis of Financial Condition and Results of Operations
38
Management
48
Transactions with Related Persons
50
Executive Compensation
50
Beneficial Ownership of Principal Stockholders, Officers and Directors
51
Legal Matters
53
Disclosure of Commission Position of Indemnification For Securities Act Liabilities
53
Experts
53
Where You Can Find Additional Information
53
Index to Financial Statements
F-1
i
PROSPECTUS SUMMARY
This summary highlights selected information
contained elsewhere in this prospectus.  This summary does not contain all the information that you should consider before
investing in the common stock. Before making an investment decision, you should carefully read the entire prospectus. In particular,
attention should be directed to the sections entitled "Risk Factors", "Business", "Management's
Discussion and Analysis of Financial Condition and Results of Operations" and the financial statements and related notes
thereto contained herein.
Business Overview
We are a commercial stage biotechnology
acceleration and development company focused on acquiring and in-licensing pre-clinical, clinical-stage and approved life sciences
therapeutic products. Currently, we have a portfolio of five products, including two FDA approved commercially available radiopharmaceuticals
for metastatic cancer bone pain (Strontium-89 and Metastron
TM
) and three development stage products: QBM-001 for rare
pediatric non-verbal autism spectrum disorder, Uttroside-B for liver cancer, and MAN 01 for glaucoma. Our licensed MAN platform
has several potential therapeutics in development in various indications, including vascular and infectious diseases. The infectious
diseases we may ultimately treat include influenza, Coronavirus, Ebola and others. We aim to maximize risk-adjusted returns by
focusing on multiple assets throughout the discovery and development cycle. We expect to benefit from early positioning in illiquid
and/or less well known privately-held assets, thereby enabling us to capitalize on valuation growth as these assets move forward
in their development.
Our mission is to:
(i)
license and acquire pre-commercial innovative life sciences assets in different stages of development and therapeutic areas from academia or small private companies;
(ii)
license and acquire FDA approved drugs and medical devices with limited current and commercial activity; and
(iii)
accelerate and advance our assets to the next value inflection point by providing strategic capital, business development and financial advice and experienced sector specific advisors.
In calendar 2020, we started generating
revenue from our Metastron and Strontium-89 products for pain palliation in bone metastases. Further, we will begin planning our
therapeutic expansion post-marketing phase 4 trial for Strontium-89. We also intend to file investigational new drug applications,
or INDs late in 2020 or early 2021, with the FDA for each of our Uttroside-B and MAN 01 assets for the treatment of liver cancer
and glaucoma, respectively. We also intend to advance our QBM-001 asset to address a non-verbal learning disorder in autistic children.
Corporate Information
Our principal executive offices are located
at 366 Madison Avenue, 3
RD
Floor, New York, NY 10017, and our telephone number is (212) 588-0022.
The Offering
This prospectus relates to the offer and
sale from time to time of up to 5,000,000 shares of our common stock by the selling stockholder, up to 1,836,286 of which may be
issued upon the conversion of the Series A Preferred Shares by the selling stockholder or payment to the selling stockholder of
dividends thereon and 3,163,714 of which may be issued upon the conversion of Series B Preferred Shares by the selling stockholder
or payment to the selling stockholder of dividends thereon. On April 6, 2020, we entered into the Purchase Agreement with the selling
stockholder pursuant to which the selling stockholder purchased 176,566 Series A Preferred Shares and 303,134 Series B Preferred
Shares from us at an aggregate of $4,000,000 in cash and approximately $2,797,000 in convertible promissory notes.
ii
As of April 17, 2020, there were 22,468,185
shares of our common stock outstanding (of which 19,437,624 shares were held by non-affiliates), 176,566 Series A Preferred Shares
outstanding (none of which were held by affiliates) and 503,134 Series B Preferred Shares outstanding (none of which were held
by affiliates). Under the terms of a registration rights agreement entered into with the selling stockholder at the same time as
the Purchase Agreement, we must register with the U.S. Securities and Exchange Commission 5,000,000 shares of common stock for
resale by the selling stockholder, which shares represent 22.3% of our outstanding shares as of April 17, 2020 and 25.7% of such
shares held by non-affiliates.
Issuances of our common stock upon the
conversion of the Series A Preferred Shares or the Series B Preferred Shares will not affect the rights or privileges of our existing
stockholders, except that the economic and voting interests of each of our existing stockholders will be diluted as a result of
any such issuance. Although the number of shares of common stock that our existing stockholders own will not decrease, the shares
owned by our existing stockholders will represent a smaller percentage of our total outstanding shares after any such issuance
to the selling stockholder.
Common stock offered by selling stockholder:
5,000,000 shares consisting of 1,836,286
        Series A Conversion Shares and 3,163,714 Series B Conversion Shares.
Common stock outstanding:
22,468,185 shares as of April 17, 2020.
Common stock outstanding after the offering:
27,468,185 shares, assuming no additional
        shares are issued prior to completion of the offering and excluding any shares of common stock underlying any outstanding options,
        warrants or unconverted Preferred Shares.
Use of Proceeds:
We will not receive any proceeds from the
        sale of Conversion Shares by the selling stockholder.
We received net proceeds (excluding our
        expenses) of approximately $6,797,000 from the sale of Preferred Shares under the Purchase Agreement, of which $4,000,000 was in
        cash and $2,797,000 was in exchange for our outstanding convertible debentures. We intend to use the cash proceeds from the sale
        of the Preferred Shares for general working capital purposes. We will retain broad discretion over the use of these proceeds.
We will not receive any proceeds upon conversion
        of the Preferred Shares or the sale of the Conversion Shares.
Quotation of common stock:
Our common stock is listed for quotation
        on the OTCQB market under the symbol "QBIO."
Dividend policy:
We do not currently anticipate paying cash
        dividends on our common stock. Instead, we currently intend to retain any future earnings, if any, that we would have used to pay
        such dividends to fund the development and growth of our business.
Our Preferred Shares carry an annual dividend
        equal to 8% of their liquidation value, which is equal, subject to customary adjustments, to their purchase price of $10 per Preferred
        Share plus any accrued but unpaid dividends thereon. As we have sold 679,700 Preferred Shares to date for gross proceeds (and with
        a liquidation value) of $6,797,000, we will have to pay $543,760 in dividends if all of such shares remain outstanding one year
        after issuance. Such dividends are to be paid in an amount of common stock equal to the dollar value of such dividend amount divided
        by the volume weighted average price ("VWAP") of our common stock on the date of such dividend payment.
Risk factors:
An investment in our company is highly speculative and involves a significant degree of risk. See "Risk Factors" and other information included in this prospectus for a discussion of factors you should carefully consider before deciding to invest in shares of our common stock.
iii
SPECIAL NOTE REGARDING FORWARD-LOOKING
STATEMENTS
We have made statements under the captions
 "Risk Factors", "Use of Proceeds", "Management's Discussion and Analysis of Financial Condition
and Results of Operation", "Business" and elsewhere in this prospectus that are forward-looking statements. You
can identify these statements by forward-looking words such as "may", "will", "expect", "anticipate",
 "believe", "estimate" and similar terminology. Forward-looking statements address, among other things:
·
implementing and developing our clinical programs and other aspects of our business plans;
·
financing goals and plans; and
·
our expectations of when regulatory approvals will be received or other actions will be taken by
parties other than us.
We believe it is important to communicate
our expectations to our investors. However, there may be events in the future that we are not able to accurately predict or which
we do not fully control that will cause actual results to differ materially from those expressed or implied by our forward-looking
statements. These include the factors listed under "Risk Factors" and elsewhere in this prospectus.
Although we believe that our expectations
reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance,
or achievements. Our forward-looking statements are made as of the date of this prospectus, and we assume no duty to update them
or to explain why actual results may differ.
iv
RISK FACTORS
Investing in our securities involves a
high degree of risk. You should carefully consider and evaluate all of the information included and incorporated by reference or
deemed to be incorporated by reference in this prospectus. Our business, results of operations or financial condition could be
adversely affected by any of these risks or by additional risks and uncertainties not currently known to us or that we currently
consider immaterial.
Risks Related to our Company
If we do not obtain additional financing,
our business may be at risk or execution of our business plan may be delayed.
As of the date hereof, we have raised our
operating funds through contacts, high net-worth individuals and strategic investors situated in the United States and
the Cayman Islands. We have only generated minimal revenue from operations since inception, all of which in our most recent quarter.
We have limited assets upon which to commence our business operations and to rely otherwise.  At February 29, 2020, we
had cash and cash equivalents of approximately $0.7 million.  In April 2020, we netted approximately $4 million from
the sale of the Preferred Shares. Even with these additional funds and any revenues that we generate, we may have to raise additional
funds within twelve months to continue operations. Additional funding will be needed to implement our business plan that includes
various expenses such as fulfilling our obligations under licensing agreements, legal, operational set-up, general and administrative,
marketing, employee salaries and other related start-up expenses. Obtaining additional funding will be subject to various factors,
including general market conditions, investor acceptance of our business plan and initial results from our business operations.
These factors may impact the timing, amount, terms or conditions of additional financing available to us. If we are unable to raise
sufficient funds, we will be forced to scale back or cease our operations.
An overall decline in the health
of the economy and other factors impacting consumer spending, such as pandemics, natural disasters and fluctuations in inflation
and foreign currency exchange rates, may affect our ability to raise capital and to produce our sole product.
We will require
additional funding to operate as planned, and the availability of such funding is sensitive to a number of factors, such as general
current and future economic and political conditions, recession and fears of recession, unemployment, interest rates, tax rates
and policies, inflation, war and fears of war, inclement weather, natural disasters, terrorism, outbreak of viruses, widespread
illness, infectious diseases, contagions and the occurrence of unforeseen epidemics and pandemics. The current coronavirus (Covid-19)
pandemic is testing the health of capital markets, and if that health deteriorates because Covid-19 or other reasons, we may not
be able to receive the additional funding that we require to grow our business or we may only be able to obtain it on terms that
substantially dilute your ownership of common stock.
Additionally,
Covid-19 or similar disasters could interrupt the production of our sole product, FDA approved non-opioid drug Strontium89 (Strontium
Chloride Sr-89 Injection, USP). We only began producing Strontium89 for commercial sale in February 2020, and our sole source for
the raw materials necessary for that product come from Poland. If the Covid-19 or similar disaster interrupts the production or
import of the raw material or otherwise interrupts our production of Strontium89, we will no longer have a product available for
commercial sale.
Our independent registered public
accountant has issued a going concern opinion after auditing our consolidated financial statements; our ability to continue depends
on our ability to raise additional capital and our operations could be curtailed if we are unable to obtain required additional
funding when needed.
We will be required to expend substantial
amounts of working capital in order to acquire and market our proposed products and establish the necessary relationships to implement
our business plan. We were incorporated on November 22, 2013. Our operations to date were funded entirely by capital raised from
our private offering of securities. Notwithstanding the offering, we will continue to require additional financing to execute our
business strategy.  We totally depend on external sources of financing for the foreseeable future. Failure to raise additional
funds in the future will adversely affect our business operations, and may require us to suspend our operations, which in turn
may result in a loss to the purchasers of our common stock. We entirely depend on our ability to attract and receive additional
funding from either the sale of securities or the issuance of debt securities. Needed funds might never be available to us on acceptable
terms or at all. The inability to obtain sufficient funding of our operations in the future could restrict our ability to grow
and reduce our ability to continue to conduct business operations. The report of our independent registered public accounting
firm on our consolidated financial statements, included herein, raised substantial doubt about our ability to continue as a going
concern. Our ability to continue as a going concern depends on our ability to raise additional capital. If we are unable to obtain
necessary financing, we will likely be required to curtail our development plans which could cause us to become dormant. Any additional
equity financing may involve substantial dilution to our then existing stockholders.
1
Our business relies on intellectual
property owned by third parties, and this reliance exposes us to the termination of the right to use that intellectual property
and may result in inadvertent infringement of patents and proprietary rights of others.
Currently, two of our assets are based
on intellectual property that we have licensed from third parties. Our business depends on:
●
our ability to continuously use the technology related to an eye drop treatment for glaucoma, our Mannin platform, that we have licensed from Mannin Research Inc. and
●
our ability to continuously use our intellectual property relating to a chemical compound derived from the plant Solanum Nigrum Linn, also known as Black Nightshade or Makoi, that we seek to use to create a chemotherapeutic agent against liver cancer, our Uttroside platform, and that we have licensed from the Rajiv Gandhi Centre for Biotechnology, an autonomous research institute under the Government of India, known as RGCB, and the Oklahoma Medical Research Foundation, or the OMRF.
If the licenses were to terminate, we would
lose the ability to fully conduct our business pursuant to our plan of operations.  Our ability to pursue our business
plan would then depend on finding alternative platforms to license and our non-licensed platforms (SR-89 and QBM-001).  We
may not be able to find an attractive platform on a timely and cost effective basis, and even if we did, such platform might be
inferior to the ones we currently have a license to use and may not be attractive to potential customers.
Many entities, including some of our competitors,
have or may obtain patents and other intellectual property rights that cover or affect products or services related to those assets
that we license.  If a court determines that one or more aspect of the licensed platform infringes on intellectual property
owned by others, we may be required to cease using that platform, to obtain licenses from the owners of the intellectual property
or to redesign the platform in such a way as to avoid infringing the intellectual property rights. If a third party holds intellectual
property rights, it may not allow us to use its intellectual property at any price, which could materially adversely affect our
competitive position.
The Mannin platform, SR-89 platform, the
QBM-001 platform and the Uttroside platform may potentially infringe other intellectual property rights. U.S. patent applications
are generally confidential until the Patent and Trademark Office issues a patent. Therefore, we cannot evaluate the extent to which
the licensed platform may infringe claims contained in pending patent applications. Further, without lengthy litigation, it is
often not possible to determine definitively whether a claim of infringement is valid.  We may not be in a position to
protect the intellectual property that we license as we are not the owners of that intellectual property and do not currently have
the financial resources to engage in lengthy litigation.
Failure to maintain the license for,
or to acquire, the intellectual property underlying any license or sublicense on which our plan of operations is based may force
us to change our plan of operations.
We have to meet certain conditions to maintain
the licenses for the intellectual property underlying the Mannin platform and the Uttroside platform and to acquire such intellectual
property. Such conditions include payments of cash and shares of common stock, obtaining certain governmental approvals, initiating
sales of products based on the intellectual property and other matters. We might not have the resources to meet these conditions
and as a result may lose the licenses to the intellectual property that is vital to our business.
2
We lack an operating history and
have generated minimal revenues to date. If we cannot generate sufficient revenues to operate profitably, we may have to cease
operations.
As we were incorporated on November 22,
2013 and more recently changed business direction, we do not have a sufficient operating history upon which an evaluation of our
future success or failure can be made. Our ability to achieve and maintain profitability and positive cash flow depends upon our
ability to manufacture a product and to earn profit by attracting enough clients who will buy our products or services.  We
have missed several expected dates by which we had anticipated to have revenues and have only recently begun to generate minimal
revenues. Even if we substantially increase our revenues, we may never achieve profitability. Failure to generate profits could
eventually cause us to suspend, curtail or cease operations.
We may be exposed to potential risks
and significant expenses resulting from the requirements under section 404 of the Sarbanes-Oxley Act of 2002.
We are required, pursuant to Section 404
of the Sarbanes-Oxley Act of 2002, to include in our annual report our assessment of the effectiveness of our internal control
over financial reporting. We expect to incur significant continuing costs, including accounting fees and staffing costs, in order
to maintain compliance with the internal control requirements of the Sarbanes-Oxley Act of 2002. Our management concluded that
our internal controls and procedures were not effective to detect the inappropriate application of US GAAP for our most recent
fiscal year. As we develop our business, hire employees and consultants and seek to protect our intellectual property rights, our
current design for internal control over financial reporting must be strengthened to enable management to determine that our internal
controls are effective for any period, or on an ongoing basis.  Accordingly, as we develop our business, such development
and growth will necessitate changes to our internal control systems, processes and information systems, all of which will require
additional costs and expenses.
In the future, if we fail to complete the
annual Section 404 evaluation in a timely manner, we could be subject to regulatory scrutiny and a loss of public confidence in
our internal controls. In addition, any failure to implement required new or improved controls, or difficulties encountered in
their implementation, could harm our operating results or cause us to fail to meet our reporting obligations.
Limited oversight of our management
may lead to corporate conflicts.
We have only three directors, of whom two
are also officers. Accordingly, we cannot establish board committees comprised of independent members to oversee functions like
compensation or audit issues. In addition, since we only have three directors, they have significant control over all corporate
issues.
Because we are not subject to compliance
with rules requiring the adoption of certain corporate governance measures, our shareholders have limited protections against interested
director transactions, conflicts of interest and similar matters.  The Sarbanes-Oxley Act of 2002, as well as rules enacted
by the SEC, the New York Stock Exchange and the Nasdaq Stock Market, requires the implementation of various measures relating to
corporate governance. These measures are designed to enhance the integrity of corporate management and the securities markets and
apply to securities which are listed on the New York Stock Exchanges or the Nasdaq Stock Market. Because we are not presently required
to comply with many of the corporate governance provisions, we have not yet adopted these measures and, currently, would not be
able to comply with such corporate governance provisions. We do not have an audit or compensation committee comprised of independent
directors. Two of our three directors who perform these functions and are not independent directors. Thus, there is a potential
conflict in that our directors are also engaged in management and participate in decisions concerning management compensation and
audit issues that may affect management performance.
Until we have a larger board of directors
that would include a majority of independent members, if ever, there will be limited oversight of our directors' decisions
and activities and little ability for minority shareholders to challenge or reverse those activities and decisions, even if they
are not in the best interests of minority shareholders.
Additionally, our directors beneficially
own approximately 26% of our common stock. Although it is possible for them to be outvoted by the remaining shareholders at a general
or special meeting if the two directors voted together, the size of their shareholdings and the absence of any other person beneficially
owning more than 10% of our common stock would make this a difficult undertaking.
3
Because the results of preclinical
studies and early clinical trials are not necessarily predictive of future results, any product candidate we advance into clinical
trials may not have favorable results in later clinical trials, if any, or receive regulatory approval.
Pharmaceutical development has inherent
risk. We will be required to demonstrate through well-controlled clinical trials for our product candidates for our Mannin platform,
the QBM-001 platform and the Uttroside platform and any additional uses based on the SR-89 and Metastron platforms that our
product candidates are effective with a favorable benefit-risk profile for use in their target indications before we can seek regulatory
approvals for their commercial sale. Success in early clinical trials does not mean that later clinical trials will be successful
as product candidates in later-stage clinical trials may fail to demonstrate sufficient safety or efficacy despite having progressed
through initial clinical testing. We also may need to conduct additional clinical trials that are not currently anticipated. Companies
frequently suffer significant setbacks in advanced clinical trials, even after earlier clinical trials have shown promising results.
In addition, only a small percentage of drugs under development result in the submission of a New Drug Application or Biologics
License Application, known as BLA, to the U.S. Food and Drug Administration and even fewer are approved for commercialization.
Any product candidates we advance
into clinical development are subject to extensive regulation, which can be costly and time consuming, cause unanticipated delays
or prevent the receipt of the required approvals to commercialize our product candidates.
The clinical development, manufacturing,
labeling, storage, record-keeping, advertising, promotion, import, export, marketing and distribution of our product candidate,
Man-01, are subject to extensive regulation by the FDA in the United States and by comparable health authorities in foreign markets.
In the United States, we are not permitted to market our product candidates until we receive approval of a BLA from the FDA. The
process of obtaining BLA approval is expensive, often takes many years and can vary substantially based upon the type, complexity
and novelty of the products involved. In addition to the significant clinical testing requirements, our ability to obtain marketing
approval for these products depends on obtaining the final results of required non-clinical testing, including characterization
of the manufactured components of our product candidates and validation of our manufacturing processes. The FDA may determine that
our product manufacturing processes, testing procedures or facilities are insufficient to justify approval. Approval policies or
regulations may change, and the FDA has substantial discretion in the pharmaceutical approval process, including the ability to
delay, limit or deny approval of a product candidate for many reasons. Despite the time and expense invested in clinical development
of product candidates, regulatory approval is never guaranteed.
The FDA or another regulatory agency can
delay, limit or deny approval of a product candidate for many reasons, including, but not limited to:
●
the FDA or comparable foreign regulatory authorities may disagree with the design or implementation of our clinical trials;
●
we may be unable to demonstrate to the satisfaction of the FDA that a product candidate is safe and effective for any indication;
●
the FDA may not accept clinical data from trials which are conducted by individual investigators or in countries where the standard of care is potentially different from the United States;
●
results of clinical trials may not meet the level of statistical significance required by the FDA for approval;
●
we may be unable to demonstrate that a product candidate's clinical and other benefits outweigh its safety risks;
●
the FDA may disagree with our interpretation of data from preclinical studies or clinical trials;
●
the FDA may fail to approve our manufacturing processes or facilities or those of third-party manufacturers with which we or our collaborators contract for clinical and commercial supplies; or
●
the approval policies or regulations of the FDA may significantly change in a manner rendering our clinical data insufficient for approval.
4
With respect to foreign markets, approval
procedures vary among countries and, in addition to the aforementioned risks, can involve additional product testing, administrative
review periods and agreements with pricing authorities. In addition, recent events raising questions about the safety of certain
marketed pharmaceuticals may result in increased cautiousness by the FDA and comparable foreign regulatory authorities in reviewing
new pharmaceuticals based on safety, efficacy or other regulatory considerations and may result in significant delays in obtaining
regulatory approvals. Any delay in obtaining, or inability to obtain, applicable regulatory approvals would prevent us from commercializing
our product candidates.
Any product candidate we manufacture
or advance into clinical trials may cause unacceptable adverse events or have other properties that may delay or prevent their
regulatory approval or commercialization or limit their commercial potential.
Unacceptable adverse events caused by any
of our product candidates that we manufacture or advance into clinical trials could cause us or regulatory authorities to interrupt,
delay or halt production or clinical trials and could result in the denial of regulatory approval by the FDA or other regulatory
authorities for any or all targeted indications and markets. This, in turn, could prevent us from commercializing the affected
product candidate and generating revenues from its sale.
Except for our Strontium Chloride 89, known
as SR89, and Metastron product candidates, there is not yet completed testing of any of our product candidates for the treatment
of the indications for which we intend to seek product approval in humans, and we currently do not know the extent of adverse events,
if any, that will be observed in patients who receive any of our product candidates. If any of our product candidates cause unacceptable
adverse events in clinical trials, we may not be able to obtain regulatory approval or commercialize such product or, if such product
candidate is approved for marketing, future adverse events could cause us to withdraw such product from the market.
Delays in the commencement of our
clinical trials could result in increased costs and delay our ability to pursue regulatory approval.
The commencement of clinical trials can
be delayed for a variety of reasons, including delays in:
●
obtaining regulatory clearance to commence a clinical trial;
●
identifying, recruiting and training suitable clinical investigators;
●
reaching agreement on acceptable terms with prospective clinical research organizations ("CROs") and trial sites, the terms of which can be subject to extensive negotiation, may be subject to modification from time to time and may vary significantly among different CROs and trial sites;
●
obtaining sufficient quantities of a product candidate for use in clinical trials;
●
obtaining Investigator Review Board, or IRB, or ethics committee approval to conduct a clinical trial at a prospective site;
●
identifying, recruiting and enrolling patients to participate in a clinical trial; and
●
retaining patients who have initiated a clinical trial but may withdraw due to adverse events from the therapy, insufficient efficacy, fatigue with the clinical trial process or personal issues.
Any delays in the commencement of our clinical
trials will delay our ability to pursue regulatory approval for our product candidates. In addition, many of the factors that cause,
or lead to, a delay in the commencement of clinical trials may also ultimately lead to the denial of regulatory approval of a product
candidate.
5
Suspensions or delays in the completion
of clinical testing could result in increased costs to us and delay or prevent our ability to complete development of that product
or generate product revenues.
Once a clinical trial has begun, patient
recruitment and enrollment may be slower than we anticipate. Clinical trials may also be delayed as a result of ambiguous or negative
interim results or difficulties in obtaining sufficient quantities of product manufactured in accordance with regulatory requirements
and on a timely basis. Further, a clinical trial may be modified, suspended or terminated by us, an IRB, an ethics committee or
a data safety monitoring committee overseeing the clinical trial, any clinical trial site with respect to that site, or the FDA
or other regulatory authorities due to a number of factors, including:
●
failure to conduct the clinical trial in accordance with regulatory requirements or our clinical protocols;
●
inspection of the clinical trial operations or clinical trial sites by the FDA or other regulatory authorities resulting in the imposition of a clinical hold;
●
stopping rules contained in the protocol;
●
unforeseen safety issues or any determination that the clinical trial presents unacceptable health risks; and
●
lack of adequate funding to continue the clinical trial.
Changes in regulatory requirements and
guidance also may occur and we may need to amend clinical trial protocols to reflect these changes. Amendments may require us to
resubmit our clinical trial protocols to IRBs for re-examination, which may impact the costs, timing and the likelihood of a successful
completion of a clinical trial. If we experience delays in the completion of, or if we must suspend or terminate, any clinical
trial of any product candidate, our ability to obtain regulatory approval for that product candidate will be delayed and the commercial
prospects, if any, for the product candidate may suffer as a result. In addition, any of these factors may also ultimately lead
to the denial of regulatory approval of a product candidate.
Our product candidates (if approved)
or any other product candidates that we may develop and market may be later withdrawn from the market or subject to promotional
limitations.
We may not be able to obtain the labeling
claims necessary or desirable for the promotion of our product candidates if approved. We may also be required to undertake post-marketing
clinical trials. If the results of such post-marketing studies are not satisfactory or if adverse events or other safety issues
arise after approval, the FDA or a comparable regulatory agency in another country may withdraw marketing authorization or may
condition continued marketing on commitments from us that may be expensive and/or time consuming to complete. In addition, if we
or others identify adverse side effects after any of our products are on the market, or if manufacturing problems occur, regulatory
approval may be withdrawn and reformulation of our products, additional clinical trials, changes in labeling of our products and
additional marketing applications may be required. Any reformulation or labeling changes may limit the marketability of our products
if approved.
Our dependence on third party suppliers
or our inability to successfully produce any product could adversely impact our business.
We rely on third parties to supply us with
component and materials required for the development and manufacture of our product and our product candidates. For example, we
receive all of the raw material for our Strontium89 product from the National Centre for Nuclear Research, Radioisotope Centre
("Polatom") in Poland, and we rely on IsoTherapeutics to manufacture that raw material into Strontium89. If any such
third parties fail to provide the required components or we are unable to find a partner to manufacture the necessary products,
there would be a significant interruption of our supply, which would materially adversely affect clinical development and the commercialization
and potential commercialization of our product and product candidates. In the event that the FDA or such other agencies determine
that we or any third-party suppliers have not complied with cGMP, our clinical trials could be terminated or subjected to a clinical
hold until such time as we or any third party are able to obtain appropriate replacement material. Furthermore, if any contract
manufacturers who supply us cannot successfully manufacture material that conforms to our specifications and with FDA regulatory
requirements, we will not be able to secure and/or maintain FDA approval for our product candidates. We, and any third-party suppliers
are and will be required to maintain compliance with cGMPs and will be subject to inspections by the FDA or comparable agencies
in other jurisdictions to confirm such compliance.
We do and will also rely on our partners
and manufacturers to purchase from third-party suppliers the materials necessary to produce our product candidates for our anticipated
clinical trials. We do not have any control over the process or timing of the acquisition of raw materials by our manufacturers.
Moreover, we currently do not have any agreements for the commercial production of these raw materials. Any significant delay in
the supply of a product candidate or the raw material components thereof for an ongoing clinical trial could considerably delay
completion of our clinical trials, product testing and potential regulatory approval of our product candidates.
6
We may not have the resources or capacity
to commercially manufacture our product candidates, and we will likely continue to be dependent upon third party manufacturers.
Our current inability, or our dependence on third parties, to manufacture and supply us with clinical trial materials and any approved
products may adversely affect our ability to develop and commercialize our product candidates on a timely basis or at all.
We intend to contract with third
parties either directly or through our licensors for the manufacture of our product candidates. This reliance on third parties
increases the risk that we will not have sufficient quantities of our product candidates or that such supply will not be available
to us at an acceptable cost, which could delay, prevent or impair our commercialization efforts.
We do not have any manufacturing facilities.
We expect to use third-party manufacturers for the manufacture of our product candidates and have entered into contracts with manufacturers
through the licensor of our radio-pharmaceutical product, SR89. Even with such contracts in place, reliance on third-party manufacturers
entails additional risks, including:
●
reliance on the third party for regulatory compliance and quality assurance;
●
the possible breach of the manufacturing agreement by the third party;
●
the possible termination or nonrenewal of the agreement by the third party at a time that is costly or inconvenient for us; and
●
reliance on the third party for regulatory compliance, quality assurance, and safety and pharmacovigilance reporting.
Third-party manufacturers may not be able
to comply with current good manufacturing practices, or cGMP, regulations or similar regulatory requirements outside the United
States. Our failure, or the failure of our third-party manufacturers, to comply with applicable regulations could result in sanctions
being imposed on us, including fines, injunctions, civil penalties, delays, suspension or withdrawal of approvals, license revocation,
seizures or recalls of product candidates or medicines, operating restrictions and criminal prosecutions, any of which could significantly
and adversely affect supplies of our medicines and harm our business and results of operations.
Any product that we may produce may compete
with other product candidates and products for access to manufacturing facilities. There are a limited number of manufacturers
that operate under cGMP regulations and that might be capable of manufacturing for us. Any performance failure on the part
of future manufacturers could result in a decrease or end to revenue. If any a contract manufacturer cannot perform as agreed,
we may be required to replace that manufacturer. We may incur added costs and delays in identifying and qualifying any such replacement.
Our anticipated future dependence upon
others for the manufacture of our product candidates may adversely affect our future profit margins and our ability to commercialize
any medicines that receive marketing approval on a timely and competitive basis.
We will likely rely on third parties
to conduct our clinical trials. If these third parties do not meet our deadlines or otherwise conduct the trials as required, our
clinical development programs could be delayed or unsuccessful and we may not be able to obtain regulatory approval for or commercialize
our product candidates when expected or at all.
We do not have the ability to conduct all
aspects of our preclinical testing or clinical trials ourselves. We intend to use, and do use, Mannin, RGCB, OMRF and CROs
to conduct our planned clinical trials and will and do rely upon such CROs, as well as medical institutions, clinical investigators
and consultants, to conduct our trials in accordance with our clinical protocols. Our CROs, investigators and other third parties
will and do play a significant role in the conduct of these trials and the subsequent collection and analysis of data from the
clinical trials.
There is no guarantee that any CROs, investigators
and other third parties upon which we rely for administration and conduct of our clinical trials will devote adequate time and
resources to such trials or perform as contractually required. If any of these third parties fail to meet expected deadlines, fail
to adhere to our clinical protocols or otherwise perform in a substandard manner, our clinical trials may be extended, delayed
or terminated. If any of our clinical trial sites terminate for any reason, we may experience the loss of follow-up information
on patients enrolled in our ongoing clinical trials unless we are able to transfer the care of those patients to another qualified
clinical trial site. In addition, principal investigators for our clinical trials may serve as scientific advisors or consultants
to us from time to time and receive cash or equity compensation in connection with such services. If these relationships and any
related compensation result in perceived or actual conflicts of interest, the integrity of the data generated at the applicable
clinical trial site may be jeopardized.
7
If our competitors develop treatments
for the target indications of our product candidates that are approved more quickly, marketed more successfully or demonstrated
to be more effective than our product candidates, our commercial opportunity will be reduced or eliminated.
We operate in highly competitive segments
of the biotechnology and biopharmaceutical markets. We face competition from many different sources, including commercial pharmaceutical
and biotechnology enterprises, academic institutions, government agencies, and private and public research institutions. Our product
candidates, if successfully manufactured and/or developed and approved, will compete with established therapies, as well as new
treatments that may be introduced by our competitors. Many of our competitors have significantly greater financial, product development,
manufacturing and marketing resources than us. Large pharmaceutical companies have extensive experience in clinical testing and
obtaining regulatory approval for drugs. In addition, many universities and private and public research institutes are active in
cancer research, some in direct competition with us. We also may compete with these organizations to recruit management, scientists
and clinical development personnel. Smaller or early-stage companies may also prove to be significant competitors, particularly
through collaborative arrangements with large and established companies. New developments, including the development of other biological
and pharmaceutical technologies and methods of treating disease, occur in the pharmaceutical and life sciences industries at a
rapid pace. Developments by competitors may render our product candidates obsolete or noncompetitive. We will also face competition
from these third parties in recruiting and retaining qualified personnel, establishing clinical trial sites and patient registration
for clinical trials and in identifying and in-licensing new product candidates.
If competitors introduce their own
generic equivalent of our SR89 product candidates, our revenues and gross margin from such products could decline rapidly.
Revenues and gross margin derived from
generic pharmaceutical products often follow a pattern based on regulatory and competitive factors that we believe are unique to
the generic pharmaceutical industry. As the patent(s) for a brand name product or the statutory marketing exclusivity period (if
any) expires, the first generic manufacturer to receive regulatory approval for a generic equivalent of the product often is able
to capture a substantial share of the market. However, as other generic manufacturers receive regulatory approvals for their own
generic versions, that market share, and the price of that product, will typically decline depending on several factors, including
the number of competitors, the price of the branded product and the pricing strategy of the new competitors. The number of our
competitors producing a generic version equivalent to our SR89 product candidates could increase to such an extent that we may
stop marketing our product for which we previously obtained approval, which would have a material adverse impact on our revenues,
if we ever achieve revenues, and gross margin.
We may expend our limited resources
to pursue a particular product candidate or indication and fail to capitalize on product candidates or indications for which there
may be a greater likelihood of success.
Because we have limited financial and managerial
resources, we will focus on a limited number of research programs and product candidates for specific indications. As a result,
we may forego or delay pursuit of opportunities with other product candidates for other indications for which there may be a greater
likelihood of success or may prove to have greater commercial potential. Notwithstanding our investment to date and anticipated
future expenditures on MAN 01 (Mannin), Uttroside-B (OMRF), QBM001 and SR-89, we have not yet developed, and may never successfully
develop, any marketed treatments using these products other than the SR89 product candidates for which there is FDA approval. Research
programs to identify new product candidates or pursue alternative indications for current product candidates require substantial
technical, financial and human resources. Although we intend to, and do, support certain investigator-sponsored clinical trials
of MAN 01, Uttroside-B, QBM001 evaluating various indications, as well as other uses of SR89, these activities may initially show
promise in identifying potential product candidates or indications, yet fail to yield product candidates or indications for further
clinical development.
8
We depend upon the services of our
key management personnel, and the loss of their services would likely result in disruptions of our operations and have a material
adverse effect on our business.
Our management and operations are dependent
on the services of our management team, namely Mr. Denis Corin, our Chief Executive Officer and Chairman, and Mr. William Rosenstadt,
our Chief Legal Officer and a Director.  We do not have employment or non-compete agreements with or maintain key-man life
insurance in respect of either of these individuals.  Because of their knowledge of the industry and our operations and their
experience with us, we believe that our future results depend upon their efforts, and the loss of the services of either of these
individuals for any reason could result in a disruption of our operations which will likely have a material adverse effect on our
business.
Other than our Chief Executive Officer,
we currently do not have full-time employees, but we retain the services of independent contractors/consultants on a contract-employment
basis. Our ability to manage growth effectively will require us to continue to implement and improve our management systems and
to recruit and train new employees. We might not be able to successfully attract and retain skilled and experienced personnel.
If we fail to attract and retain
key management and clinical development personnel, we may be unable to successfully develop or commercialize our product candidates.
We will need to expand and effectively
manage our managerial, operational, financial and other resources in order to successfully pursue our clinical development and
commercialization efforts. As a company with a limited number of personnel, we highly depend on the development, regulatory, commercial
and financial expertise of the members of our senior management and advisors, in particular Denis Corin, our chairman and chief
executive officer. The loss of this individual or the services of any of our other senior management could delay or prevent the
further development and potential commercialization of our product candidates and, if we are not successful in finding suitable
replacements, could harm our business. Our success also depends on our continued ability to attract, retain and motivate highly
qualified management and scientific personnel and we may not be able to do so in the future due to the intense competition for
qualified personnel among biotechnology and pharmaceutical companies, as well as universities and research organizations. If we
are not able to attract and retain the necessary personnel, we may experience significant impediments to our ability to implement
our business strategy.
Applicable regulatory requirements,
including those contained in and issued under the Sarbanes-Oxley Act of 2002, may make it difficult for us to retain or attract
qualified officers and directors, which could adversely affect the management of our business and our ability to retain listing
of our common stock.
We may be unable to attract and retain
those qualified officers, directors and members of board committees required to provide for effective management because of the
rules and regulations that govern publicly-held companies, including, but not limited to, certifications by principal executive
officers. The enactment of the Sarbanes-Oxley Act has resulted in the issuance of a series of related rules and regulations and
the strengthening of existing rules and regulations by the SEC, as well as the adoption of new and more stringent rules by the
stock exchanges. The perceived increased personal risk associated with these changes may deter qualified individuals from accepting
roles as directors and executive officers.
Further, some of these changes heighten
the requirements for board or committee membership, particularly with respect to an individual's independence from our business
and level of experience in finance and accounting matters. We may have difficulty attracting and retaining directors with the requisite
qualifications. If we are unable to attract and retain qualified officers and directors, the management of our business and our
ability to obtain or retain listing of our shares of common stock on any stock exchange could be adversely affected.
We may be exposed to potential risks
and significant expenses resulting from the requirements under section 404 of the Sarbanes-Oxley Act of 2002.
We are required, pursuant to Section 404
of the Sarbanes-Oxley Act of 2002, to include in our annual report our assessment of the effectiveness of our internal control
over financial reporting. We expect to incur significant continuing costs, including accounting fees and staffing costs, in order
to maintain compliance with the internal control requirements of the Sarbanes-Oxley Act of 2002. Our management concluded that
our internal controls and procedures were not effective to detect the inappropriate application of US GAAP for our most recent
fiscal year. As we develop our business, hire employees and consultants and seek to protect our intellectual property rights, our
current design for internal control over financial reporting must be strengthened to enable management to determine that our internal
controls are effective for any period, or on an ongoing basis.  Accordingly, as we develop our business, such development
and growth will necessitate changes to our internal control systems, processes and information systems, all of which will require
additional costs and expenses.
9
In the future, if we fail to complete the
annual Section 404 evaluation in a timely manner, we could be subject to regulatory scrutiny and a loss of public confidence in
our internal controls. In addition, any failure to implement required new or improved controls, or difficulties encountered in
their implementation, could harm our operating results or cause us to fail to meet our reporting obligations.
Because of the small size of our
company, we do not have separate Chairman, Chief Executive Officer and Chief Financial Officer positions, which may expose us to
potential risks, including our failure to produce reliable financial reports and prevent and/or detect fraud.
We have not adopted a formal policy to
separate or combine the positions of Chairman and Chief Executive Officer, both of which are currently held by Denis Corin who
is also our acting principal financial officer.  In addition, our CEO and CLO also comprise the majority of our Board of Directors. 
As such, there is no division of labor between our management and of our Board of Directors.  This structure exposes us to
a number of risks, including a failure to maintain adequate internal controls, our failure to produce reliable financial reports
and our failure to prevent and/or detect financial fraud.  Any such failures would adversely affect our financial condition
and overall business operations.
We are required, pursuant to Section 404
of the Sarbanes-Oxley Act of 2002, to include in our annual report our assessment of the effectiveness of our internal control
over financial reporting. We expect to incur significant continuing costs, including accounting fees and staffing costs, in order
to maintain compliance with the internal control requirements of the Sarbanes-Oxley Act of 2002. Our management concluded that
our internal controls and procedures were not effective to detect the inappropriate application of US GAAP for our most recent
fiscal year. As we develop our business, hire employees and consultants and seek to protect our intellectual property rights, our
current design for internal control over financial reporting must be strengthened to enable management to determine that our internal
controls are effective for any period, or on an ongoing basis.  Accordingly, as we develop our business, such development
and growth will necessitate changes to our internal control systems, processes and information systems, all of which will require
additional costs and expenses. Among other outcomes, a downturn in general economic conditions could:
●
increase the cost of raising, or decrease our ability to raise, additional funds; as we do not anticipate generating sufficient revenue in the next twelve months to cover our operating costs, we may need to raise additional funding to implement our business if we do not raise sufficient funds in this offering. A recession or other negative economic factors could make this more difficult or prohibitive; or
●
interfere with services provided by third parties; we use third parties for research purposes and intend to use third parties for the production and distribution of our generic SR89 product candidate, and a general recession or other economic conditions could jeopardize the ability of any third parties to fulfill their obligations to us;
In the future, if we fail to complete the
annual Section 404 evaluation in a timely manner, we could be subject to regulatory scrutiny and a loss of public confidence in
our internal controls. In addition, any failure to implement required new or improved controls, or difficulties encountered in
their implementation, could harm our operating results or cause us to fail to meet our reporting obligations.
Two of our assets may compete with
each other and we will need to address how to proceed with each asset
Our Strontium Chloride 89 product from
BNI is the generic version of our Metastron product that we acquired from GE Healthcare Limited. Having two products based on the
same drug for the same bone cancer pain mediation therapy may prove to be redundant. We have not yet decided how to proceed with
these assets if they prove to be redundant, but we may have to abandon one of the products or severely curtail our plans for its
development. Any such abandonment or curtailment would reduce potential income from such product.
10
Risks Related to our Industry
We are subject to general economic
conditions outside of our control.
Projects for the acquisition and development
of our products are subject to many factors, which are outside our control.  These factors include general economic conditions
in North America and worldwide (such as recession, inflation, unemployment, and interest rates), shortages of labor and materials
and price of materials and competitive products and the regulation by federal and state governmental authorities. If any or several
of these facts develop in a way that is adverse to our interest, we will not be in a position to reverse them, and we may not be
able to survive such a development.
If any product candidate that we
successfully develop does not achieve broad market acceptance among physicians, patients, healthcare payors and the medical community,
the revenues that it generates from their sales will be limited.
Even if we successfully produce product
candidates, they may not gain market acceptance among physicians, patients, healthcare payors and the medical community. Coverage
and reimbursement of our product candidates by third-party payors, including government payors, generally is also necessary for
commercial success. The degree of market acceptance of any approved products will depend on a number of factors, including:
●
the efficacy and safety as demonstrated in clinical trials;
●
the clinical indications for which the product is approved;
●
acceptance by physicians, major operators of hospitals and clinics and patients of the product as a safe and effective treatment;
●
acceptance of the product by the target population;
●
the potential and perceived advantages of product candidates over alternative treatments;
●
the safety of product candidates seen in a broader patient group, including its use outside the approved indications;
●
the cost of treatment in relation to alternative treatments;
●
the availability of adequate reimbursement and pricing by third parties and government authorities;
●
relative convenience and ease of administration;
●
the prevalence and severity of adverse events;
●
the effectiveness of our sales and marketing efforts; and
●
unfavorable publicity relating to the product.
If any product candidate is approved but
does not achieve an adequate level of acceptance by physicians, hospitals, healthcare payors and patients, we may not generate
sufficient revenue from these products and may not become or remain profitable.
11
We may incur substantial product
liability or indemnification claims relating to the clinical testing and/or use of our product candidates.
We face an inherent risk of product liability
exposure related to the testing of our product candidates in human clinical trials, as well as related to the manufacture and consumption
of product candidates that we successfully commercialize. Claims could be brought against us if use or misuse of one of our product
candidates causes, or merely appears to have caused, personal injury or death. We maintain a $5 Million product liability policy.
Such coverage may not be sufficient to cover claims that may be made against us and we may be unable to maintain such insurance.
Any claims against us, regardless of their merit, could severely harm our financial condition, strain our management and other
resources or destroy the prospects for commercialization of the product which is the subject of any such claim. Additionally, we
have entered into various agreements where we indemnify third parties for certain claims relating to our product candidates. These
indemnification obligations may require us to pay significant sums of money for claims that are covered by these indemnifications.
Healthcare reform and restrictions
on reimbursements may limit our financial returns.
Our ability or the ability of our collaborators
to commercialize any of our product candidates that we successfully develop may depend, in part, on the extent to which government
health administration authorities, private health insurers and other organizations will reimburse consumers for the cost of these
products. These third parties are increasingly challenging both the need for and the price of new drug products. Significant uncertainty
exists as to the reimbursement status of newly approved therapeutics. Adequate third-party reimbursement may not be available for
our product candidates to enable us or our collaborators to maintain price levels sufficient to realize an appropriate return on
their and our investments in research and product development.
Our success depends upon intellectual
property, proprietary technologies and regulatory market exclusivity periods, and the intellectual property protection for our
product candidates depends significantly on third parties.
Our success depends, in large part, on
obtaining and maintaining patent protection and trade secret protection for our product candidates and their formulations and uses,
as well as successfully defending these patents against third-party challenges. The parties from which we license our intellectual
property are responsible for prosecuting and maintaining patent protection relating to the intellectual property to which we have
a license from that party. If any of these parties fails to appropriately prosecute and maintain patent protection for the intellectual
property, our ability to develop and commercialize the respective product candidate may be adversely affected and we may not be
able to prevent competitors from making, using and selling competing products. This failure to properly protect the intellectual
property rights could have a material adverse effect on our financial condition and results of operations.
The patent application process is subject
to numerous risks and uncertainties, and we or our partners might not be successful in protecting our product candidates by obtaining
and defending patents. These risks and uncertainties include the following:
●
patent applications may not result in any patents being issued;
●
patents that may be issued or in-licensed may be challenged, invalidated, modified, revoked, circumvented, found to be unenforceable, or otherwise may not provide any competitive advantage;
●
our competitors, many of which have substantially greater resources than we or our partners and many of which have made significant investments in competing technologies, may seek, or may already have obtained, patents that will limit, interfere with, or eliminate our ability to make, use and sell our potential products;
●
there may be significant pressure on the U.S. government and other international governmental bodies to limit the scope of patent protection both inside and outside the United States for disease treatments that prove successful as a matter of public policy regarding worldwide health concerns; and
●
countries other than the United States may have patent laws less favorable to patentees than those upheld by U.S. courts, allowing foreign competitors a better opportunity to create, develop, and market competing products.
In addition to patents, we and our partners
also rely on trade secrets and proprietary know-how. Although we have taken steps to protect our trade secrets and unpatented know-how,
including entering into confidentiality agreements with third parties, and confidential information and inventions agreements with
employees, consultants and advisors, third parties may still obtain this information or come upon this same or similar information
independently.
12
We also intend to rely on our ability to
obtain and maintain a regulatory period of market exclusivity for any of our biologic product candidates that are successfully
developed and approved for commercialization. Although this period in the United States is currently 12 years from the date of
marketing approval, there is a risk that the U.S. Congress could amend laws to significantly shorten this exclusivity period. Once
any regulatory period of exclusivity expires, depending on the status of our patent coverage and the nature of the product, we
may not be able to prevent others from marketing products that are biosimilar to or interchangeable with our products, which would
materially adversely affect us.
In addition, U.S. patent laws may change
which could prevent or limit us from filing patent applications or patent claims to protect our products and/or technologies or
limit the exclusivity periods that are available to patent holders. For example, on September 16, 2011, the Leahy-Smith America
Invents Act, or the America Invents Act, was signed into law, and includes a number of significant changes to U.S. patent law.
These include changes to transition from a "first-to-invent" system to a "first-to-file" system and to
the way issued patents are challenged. These changes may favor larger and more established companies that have more resources to
devote to patent application filing and prosecution. The U.S. Patent and Trademark Office implemented the America Invents Act on
March 16, 2013, and it remains to be seen how the judicial system and the U.S. Patent and Trademark Office will interpret
and enforce these new laws. Accordingly, it is not clear what impact, if any, the America Invents Act will ultimately have on the
cost of prosecuting our patent applications, our ability to obtain patents based on our discoveries and our ability to enforce
or defend our issued patents.
If we or our partners are sued for
infringing intellectual property rights of third parties, it will be costly and time consuming, and an unfavorable outcome in that
litigation would have a material adverse effect on our business.
Our success also depends on our ability
and the ability of any of our current or future collaborators to develop, manufacture, market and sell our product candidates without
infringing the proprietary rights of third parties. Numerous U.S. and foreign issued patents and pending patent applications, which
are owned by third parties, exist in the fields in which we are developing products, some of which may be directed at claims that
overlap with the subject matter of our intellectual property. Because patent applications can take many years to issue, there may
be currently pending applications, unknown to us, which may later result in issued patents that our product candidates or proprietary
technologies may infringe. Similarly, there may be issued patents relevant to our product candidates of which we are not aware.
There is a substantial amount of litigation
involving patent and other intellectual property rights in the biotechnology and biopharmaceutical industries generally. If a third-party
claims that we or any of our licensors, suppliers or collaborators infringe the third party's intellectual property rights,
we may have to:
●
obtain licenses, which may not be available on commercially reasonable terms, if at all;
●
abandon an infringing product candidate or redesign our products or processes to avoid infringement;
●
pay substantial damages, including the possibility of treble damages and attorneys' fees, if a court decides that the product or proprietary technology at issue infringes on or violates the third party's rights;
●
pay substantial royalties, fees and/or grant cross licenses to our technology; and/or
●
defend litigation or administrative proceedings which may be costly whether we win or lose, and which could result in a substantial diversion of our financial and management resources.
We may be involved in lawsuits to
protect or enforce our patents or the patents of our licensors, which could be expensive, time consuming and unsuccessful.
Competitors may infringe our patents or
the patents of our licensors. To counter infringement or unauthorized use, we may be required to file infringement claims, which
can be expensive and time-consuming. An adverse result in any litigation or defense proceedings could put one or more of our patents
at risk of being invalidated, found to be unenforceable, or interpreted narrowly and could put our patent applications at risk
of not issuing. Furthermore, because of the substantial amount of discovery required in connection with intellectual property litigation,
there is a risk that some of our confidential information could be compromised by disclosure during this type of litigation.
13
We may be subject to claims that
our consultants or independent contractors have wrongfully used or disclosed alleged trade secrets of their other clients or former
employers to us.
As is common in the biotechnology and pharmaceutical
industry, we engage the services of consultants to assist us in the development of our product candidates. Many of these consultants
were previously employed at, or may have previously been or are currently providing consulting services to, other biotechnology
or pharmaceutical companies, including our competitors or potential competitors. We may become subject to claims that we or these
consultants have inadvertently or otherwise used or disclosed trade secrets or other proprietary information of their former employers
or their former or current customers. Litigation may be necessary to defend against these claims. Even if we are successful in
defending against these claims, litigation could result in substantial costs and be a distraction to management.
Risks Related to our Securities
Our shares
of common stock are subject to the "penny stock' rules of the securities and exchange commission and the trading market
in our securities will be limited, which will make transactions in our stock cumbersome and may reduce the value of an investment
in our stock.
The U.S. Securities
and Exchange Commission (the "SEC") has adopted rules that regulate broker-dealer practices in connection with transactions
in "penny stocks."  Penny stocks generally are equity securities with a price of less than $5 (other than securities
registered on certain national securities exchanges or quoted on the NASDAQ system, provided that current price and volume information
with respect to transactions in such securities is provided by the exchange or system).  Penny stock rules require a broker-dealer,
prior to a transaction in a penny stock not otherwise exempt from those rules, to deliver a standardized risk disclosure document
prepared by the SEC, which specifies information about penny stocks and the nature and significance of risks of the penny stock
market.  A broker-dealer must also provide the customer with bid and offer quotations for the penny stock, the compensation
of the broker-dealer, and sales person in the transaction, and monthly account statements indicating the market value of each penny
stock held in the customer's account.  In addition, the penny stock rules require that, prior to a transaction in a penny
stock not otherwise exempt from those rules, the broker-dealer must make a special written determination that the penny stock is
a suitable investment for the purchaser and receive the purchaser's written agreement to the transaction.  These disclosure
requirements may have the effect of reducing the trading activity in the secondary market for stock that becomes subject to those
penny stock rules.  If a trading market for our common stock develops, our common stock will probably become subject to the
penny stock rules, and shareholders may have difficulty in selling their shares.
Any additional
financing may dilute existing shareholders and decrease the market price for shares of our common stock.
If we raise additional
capital, our existing shareholders may incur substantial and immediate dilution. We estimate that we will need approximately $4,000,000
in additional funds over the next year for our business plan. The most likely source of future funds available to us is through
the sale of additional shares of common stock. Such sales might occur below market price and below the price of which existing
shareholders purchased their shares.
Our Articles
of Incorporation provide indemnification for officers, directors and employees.
Our governing
instruments provide that officers, directors, employees and other agents and their affiliates shall only be liable to our Company
for losses, judgments, liabilities and expenses that result from the negligence, misconduct, fraud or other breach of fiduciary
obligations. Thus, certain alleged errors or omissions might not be actionable by us. The governing instruments also provide that,
under the broadest circumstances allowed under law, we must indemnify our officers, directors, employees and other agents and their
affiliates for losses, judgments, liabilities, expenses and amounts paid in settlement of any claims sustained by them in connection
with our Company, including liabilities under applicable securities laws.
14
The market
price of our common stock may be volatile and may fluctuate in a way that is disproportionate to our operating performance.
Our shares of
common stock trading on the OTCQB will fluctuate significantly. There is a volatility associated with Bulletin Board securities
in general and the value of your investment could decline due to the impact of any of the following factors upon the market price
of our common stock:
•
sales or potential sales of substantial amounts of our
common stock;
•
delay or failure in initiating or completing pre-clinical
or clinical trials or unsatisfactory results of these trials;
•
announcements about us or about our competitors, including
clinical trial results, regulatory approvals or new product introductions;
•
developments concerning our licensors, product manufacturers
or our ability to produce Man-01;
•
developments concerning our licensors, product manufacturers
or our ability to produce SR89;
•
litigation and other developments relating to our patents
or other proprietary rights or those of our competitors;
•
conditions in the pharmaceutical or biotechnology industries;
•
governmental regulation and legislation;
•
variations in our anticipated or actual operating results;
•
change in securities analysts' estimates of our
performance, or our failure to meet analysts' expectations;
•
change in general economic trends; and
•
investor perception of our industry or our prospects.
Many of these
factors are beyond our control. The stock markets in general, and the market for pharmaceutical and biotechnological companies
in particular, have historically experienced extreme price and volume fluctuations. These fluctuations often have been unrelated
or disproportionate to the operating performance of these companies. These broad market and industry factors could reduce the market
price of our common stock, regardless of our actual operating performance.
Sales of
a substantial number of shares of our common stock, or the perception that such sales may occur, may adversely impact the price
of our common stock.
A large number
of our shares may be sold without restriction in public markets. These include:
•
approximately 15,416,497 of our outstanding shares of common stock recorded by our transfer agent
as of April 17, 2020 as unrestricted and freely tradable;
•
shares of our common stock (including certain shares underlying warrants and convertible debentures)
that are, or are eligible to be, unrestricted and free trading pursuant to Rule 144 or other exemptions from registration under
the Securities Act that have not yet been recorded by our transfer agent as such;
•
up to
1,711,875
shares underlying warrants that were
included on a registration declared effective by the SEC on January 12, 2018;
•
up to
953,249
shares underlying warrants that
were included on a registration declared effective by the SEC on September 26, 2017; and
•
upon the effectiveness of the registration statement of which this prospectus forms a part, up
to an additional 5,000,000 shares (approximately 22.3% of our issued and outstanding shares as of April 17, 2020).
A large portion
of the shares that are freely tradable, were issued at a price that is significantly below the closing price of $2.07 as of April
17, 2020. If the holders of our free trading shares wanted to make a profit on their investment (or if they wish to sell for a
loss), there might not be enough purchasers to maintain the market price of our common stock on the date of such sales.  Any
such sales, or the fear of such sales, could substantially decrease the market price of our common stock and the value of your
investment.
15
The exercise
of warrants or options and the conversion of Preferred Shares or future sales of our common stock may further dilute the shares
of common stock you receive in this offering.
As of the date
hereof, we have outstanding vested and unvested options and warrants exercisable into 11,020,000 shares of common stock, outstanding
Preferred Shares convertible into a maximum of 16,140,917 shares of common stock (assuming conversion at the floor price of the
respective Preferred Shares and excluding any shares that may be issued upon payments of dividends on such Preferred Shares) and
convertible debentures convertible into approximately 1,250,000 shares of our common stock at the lowest possible conversion prices.
The issuance of any shares of common stock pursuant to exercise of such options and warrants or the conversion of such notes would
dilute your percentage ownership of our Company, and the issuance of any shares of common stock pursuant to exercise of such options
and warrants or the conversion of such notes at a per share price below the offering price of shares being acquired in this offering
which would dilute the net tangible value per share for such investor.
Our Board of Directors
is authorized to sell additional shares of common stock, or securities convertible into shares of common stock, if in their discretion
they determine that such action would be beneficial to us. Approximately 95% of our authorized shares of common stock and 100%
of our shares of preferred stock are available for issuance.  Any such issuance would dilute the ownership interest of persons
acquiring common stock in this offering, and any such issuance at a share price lower than then net tangible book value per share
at the time an investor purchased its shares would dilute the net tangible value per share for such investor.
USE OF PROCEEDS
We will not receive
any proceeds from the conversion of the Preferred Shares or from the sale of the Conversion Shares by the selling stockholder.
Between April 6 and April 17, 2020, however, we sold the Preferred Shares (which account for the Conversion Shares being sold by
this Prospectus) for gross proceeds of $6,797,000. Our gross proceeds consisted of cash and outstanding convertible debentures.
Of our gross
proceeds, $4,000,000 were in cash. We intend to use the cash proceeds from the sale of the Preferred Shares for general working
capital, but we will retain broad discretion over the use of these proceeds.
Our gross proceeds
in the form of our outstanding convertible debentures consisted of:
•
$765,656 of principal and interest on a convertible debenture issued on November
1, 2018; and
•
$2,031,342 of principal and interest in convertible debentures issued on December 6, 2019 and January
15, 2020.
We received net proceeds (excluding our
expenses) of $6,782,000 from the sale of Preferred Shares under the Purchase Agreement, of which $3,985,000 was in cash.
Amount of Proceeds from Sale of Preferred
Shares
On April 6, 2020, we entered into a Purchase
Agreement pursuant to which we sold 176,566 Series A Preferred Shares and 503,134 Series B Preferred Shares, all of which we sold
to the selling stockholder, in exchange for gross proceeds of $6,797,000 (which included $2,797,000 of principal and interest on
outstanding convertible debentures held by the selling stockholder). In connection with those sales, we have paid a due diligence
fee of $15,000 for net proceeds of $6,782,000. We are required to pay a dividend on the Preferred Shares that comes out to 8% on
an annual basis, which dividend is to be paid in shares of our common stock. The following table sets out the payments we have
made and may have to make in both the first year and second year of each class of Preferred Shares (excluding any penalty we may
have to pay if we fail to deliver Conversion Shares on a timely basis and the holders buy such equivalent shares, which penalty
cannot be calculated until there is such a buy-in).
First Year of Series A Preferred Shares
First Year of Series B Preferred Shares
First Year Total
First Two Years of Series A Preferred Shares
First Two Years of Series B Preferred Shares
First Two Years Total
Due Diligence Fee
$
-
$
-
$
15,000
$
-
$
-
$
15,000
Dividend
$
141,253
$
402,507
$
543,760
$
282,506
$
805,014
$
1,087,520
Total:
$
558,760
$
1,103,520
(1)
All of the Preferred Shares have an annual dividend of 8% payable in common stock.
16
The following sets forth the gross proceeds
paid to us in connection with our issuance of the Preferred Shares, all payments that have been made or that may be required to
be made by us in connection with the issuance of the Preferred Shares in their first year, our resulting minimum net proceeds and
the combined total possible profit to be realized as a result of any conversion discounts regarding the common stock underlying
the Preferred Shares in their first year.
Gross proceeds to the Company
$
6,797,000
All payments that have been made or that may be required to be made by the Company to a selling stockholder in the first year of the Preferred Shares
$
558,760
Net proceeds to the Company if we make all such payments to a selling stockholder
$
6,238,240
All payments that have been made or that may be required to be made by the Company to a selling stockholder in the first year of the Preferred Shares as a percentage of net proceeds
9.0
%
The combined total possible profit to be realized as a result of any conversion discounts regarding the securities underlying the Preferred Shares (1)
$
3,659,225
The combined total possible profit to be realized as a result of any conversion discounts regarding the securities underlying the Preferred Shares as a percentage of net proceeds
59.2
%
(1)
As calculated in "Selling
Stockholder - Potential Profits to Selling Stockholder
"
using the date of issuance as the conversion date
for each tranche. The actual profit as a result of the conversion discount cannot be calculated until conversion as the conversion
price depends on market conditions at and before conversion, and it may be significantly greater.
DETERMINATION OF OFFERING PRICE
The selling stockholder
will offer common stock at the prevailing market prices or privately negotiated price. The offering price of our common stock does
not necessarily bear any relationship to our book value, assets, past operating results, financial condition or any other established
criteria of value. Our common stock might not trade at market prices in excess of the offering price as prices for common stock
in any public market will be determined in the marketplace and may be influenced by many factors, including the depth and liquidity.
PLAN OF DISTRIBUTION
The common stock held by the selling stockholder
may be sold or distributed from time to time by the selling stockholder directly to one or more purchasers or through brokers,
dealers, or underwriters who may act solely as agents at market prices prevailing at the time of sale, at prices related to the
prevailing market prices, at negotiated prices, or at fixed prices, which may be changed on any stock exchange, market or trading
facility on which the shares are traded or in private transactions. The sale of the selling stockholder's common stock offered
by this prospectus may be effected in one or more of the following methods:
•
ordinary brokerage transactions and transactions
in which the broker-dealer solicits purchasers;
•
transactions involving cross or block trades;
•
a purchases by a broker-dealer as principal and resale
by the broker-dealer for its account;
•
an exchange distribution in accordance with the
rules of the applicable exchange;
•
in privately negotiated transactions;
17
•
broker-dealers may agree with the selling stockholder
to sell a specified number of such shares at a stipulated price per share;
•
"at the market" into an existing market for
the common stock;
•
through the writing of options on the shares;
•
a combination of any such methods of sale; and
•
any other method permitted pursuant to applicable
law.
In order to comply with the securities
laws of certain states, if applicable, the shares of the selling stockholder may be sold only through registered or licensed brokers
or dealers. In addition, in certain states, such shares may not be sold unless they have been registered or qualified for sale
in the state or an exemption from the registration or qualification requirement is available and complied with.
The selling stockholder may also sell shares
of common stock under Rule 144 promulgated under the Securities Act, if available, or any other exemption available under the Securities
Act rather than under this prospectus. In addition, the selling stockholder may transfer the shares of common stock by other means
not described in this prospectus.
The selling stockholder may also sell the
shares directly to market makers acting as principals and/or broker-dealers acting as agents for themselves or their customers.
Such broker-dealers may receive compensation in the form of discounts, concessions or commissions from the selling stockholder
and/or the purchasers of shares for whom such broker-dealers may act as agents or to whom they sell as principal or both, which
compensation as to a particular broker-dealer might be in excess of customary commissions. Market makers and block purchasers purchasing
the shares will do so for their own account and at their own risk. It is possible that the selling stockholder will attempt to
sell shares of common stock in block transactions to market makers or other purchasers at a price per share which may be below
the then market price. The selling stockholder cannot assure that all or any of the shares offered in this prospectus will be issued
to, or sold by, it.
Brokers, dealers or agents participating
in the distribution of the shares held by a selling stockholder as agents may receive compensation in the form of commissions,
discounts, or concessions from the selling stockholder and/or purchasers of the common stock for whom the broker-dealers may act
as agent.  Such selling stockholder may agree to indemnify any agent, dealer or broker-dealer that participates in transactions
involving sales of the shares if liabilities are imposed on that person under the Securities Act.
Each selling stockholder acquired the securities
offered hereby in the ordinary course of business and has advised us that it has not entered into any agreements, understandings
or arrangements with any underwriters or broker-dealers regarding the sale of their shares of common stock, nor is there an
underwriter or coordinating broker acting in connection with a proposed sale of shares of common stock by such selling stockholder.
If we are notified by a selling stockholder that any material arrangement has been entered into with a broker-dealer for the sale
of shares of common stock, if required, we will file a supplement to this prospectus.
We may suspend the sale of shares by a
selling stockholder pursuant to this prospectus for certain periods of time for certain reasons, including if the prospectus is
required to be supplemented or amended to include additional material information.
If a selling stockholder use this prospectus
for any sale of the shares of common stock, it will be subject to the prospectus delivery requirements of the Securities Act.
Regulation M
The anti-manipulation rules of Regulation
M under the Exchange Act of 1934, as amended (the "Exchange Act") may apply to sales of our common stock and activities
of a selling stockholder.
We have advised the selling stockholder
that while it is engaged in a distribution of the shares included in this prospectus, it is required to comply with Regulation
M promulgated under the Exchange Act. With certain exceptions, Regulation M precludes the selling stockholder, any affiliated purchasers,
and any broker-dealer or other person who participates in the distribution from bidding for or purchasing, or attempting to induce
any person to bid for or purchase any security which is the subject of the distribution until the entire distribution is complete.
Regulation M also prohibits any bids or purchases made in order to stabilize the price of a security in connection with the distribution
of that security. All of the foregoing may affect the marketability of the shares offered hereby this prospectus.
18
DESCRIPTION OF SECURITIES
General
As of April 17, 2020, we are authorized
by our articles of incorporation to issue (i) 250,000,000 shares of common stock, par value $0.001 per share, of which 22,468,185
were outstanding, and (ii) 100,000,000 shares of preferred stock of which (a) 500,000 Series A Preferred Shares were authorized
and 176,566 were outstanding, (b) 1,000,000 Series B Preferred Shares were authorized and 503,134 were outstanding and (c) no other
class of preferred shares was authorized or outstanding.
This prospectus contains only a summary
of the common stock the selling stockholder is offering. The following summary of the terms of our common stock and preferred stock,
respectively, may not be complete and is subject to, and qualified in its entirety by reference to, the terms and provisions of
our amended and restated articles of incorporation and our amended and restated bylaws. You should refer to, and read this summary
together with, our amended and restated articles of incorporation and amended and restated bylaws to review all of the terms of
our common stock and preferred stock, respectively, that may be important to you.
Common Stock
Holders of our common stock are entitled
to one vote for each share held of record on each matter submitted to a vote of stockholders. Except as otherwise required by Nevada
law, and subject to the rights of the holders of preferred stock, if any, all stockholder action is taken by the vote of a majority
of the outstanding shares of common stock voting as a single class present at a meeting of stockholders at which a quorum consisting
of one-half of the outstanding shares of common stock is present in person or proxy.
Subject to the prior rights of any class
or series of preferred stock which may from time to time be outstanding, if any, holders of our common stock are entitled to receive
ratably, dividends when, as, and if declared by our board of directors out of funds legally available for that purpose and, upon
our liquidation, dissolution, or winding up, are entitled to share ratably in all assets remaining after payment of liabilities
and payment of accrued dividends and liquidation preferences on the preferred stock.
Series A Preferred Shares
The following is a summary of the rights
of the holders of the Series A Preferred Shares. All dollar amounts set out below shall be adjusted proportionally upon the occurrence
of any stock split or common stock dividend
Voting
. Except to the extent required
by law, the holders of the Series A Preferred Shares do not have the right to vote on the matters that the holders of the common
stock have the right to vote upon. The holders of the Series A Preferred Shares may vote upon matters affecting the Series A Preferred
Shares, provided that if the vote concerns all Preferred Shares, the holders of the Series A Preferred Shares shall vote together
with the holders of the Series B Preferred Shares.
Liquidation
. The holders of the
Series A Preferred Shares, together with the holders of the Series B Preferred Shares, shall have a liquidation preference over
the holders of the common stock. Such preference consists of the right to receive upon our voluntary or involuntary liquidation,
dissolution or winding up the liquidation value of each Series A Preferred Share prior to the payment of any amounts to the holders
of the common stock. The liquidation value of each Series A Preferred Share shall be equal to $10 plus any accrued but unpaid dividends
thereon.
Dividends
. Every three months, we
are required to pay each holder of Series A Preferred Shares a dividend equal to 2% of the liquidation value of such shares (which
is equal to 8% on annual basis). Such dividends shall be paid in shares of our common stock in an amount equal to the dollar amount
of such payment divided by the VWAP of our common stock on the date that such dividend payment is due, provided that we may not
issue such shares of common stock if such share issuance would cause the holder to beneficially own more than 9.99% of our common
stock.
19
Conversion
. Each Series
A Preferred Share may be converted into shares of our common stock in an amount that is equal to the liquidation value divided
by $1.00. We may force the conversion of the Series A Preferred Shares if each of the following conditions (the "Forced Equity
Conditions") has been met:
(i)
on each trading day during the period beginning ten trading days prior to
the forced conversion (the "Equity Conditions Measuring Period"), the VWAP of our common stock is in excess of $5.00,
(ii)
on each trading day during Equity Conditions Measuring Period, the dollar
volume of our common stock traded is in excess of $750,000,
(iii)
on each day during the Equity Conditions Measuring Period, the shares of
our common stock underlying the Series A Preferred Shares to be converted shall either (x) be registered for resale on an effective
registration statement or (y) eligible for resale without restriction and without the need for registration under any applicable
federal or state securities laws,
(iv)
on each day during the Equity Conditions Measuring Period, our common stock
is designated for quotation on our principal market and shall not have been suspended from trading on such exchange or market nor
shall delisting or suspension by such exchange or market been threatened or pending either (A) in writing by such exchange or market
or (B) by falling below the then effective minimum listing maintenance requirements of such exchange or market; and
(v)
during the Equity Conditions Measuring Period, there shall not have occurred
either (A) an Event of Default or (B) an event that with the passage of time or giving of notice would constitute an Event of Default.
We may not issue those shares
of common stock pursuant to the conversions discussed above that would cause a holder to beneficially own more than 9.99% of our
then outstanding common stock.
If we fail to issue and deliver
Conversion Shares by three trading days after receiving a conversion notice and such holder purchases common stock to deliver in
satisfaction of a sale by such holder of such Conversion Shares, then we shall, at such holder's discretion, either (i) pay cash
to such holder in an amount equal to such holder's total purchase price for the shares of common stock so purchased (the
"
Buy-In
Price
"
), at which point our obligation to deliver issue and deliver such shares shall terminate, or (ii) promptly
honor our obligation to deliver to such Conversion Shares and pay cash to such holder in an amount equal to the excess (if any)
of the Buy-In Price over the product of (A) such Conversion Shares times (B) the closing bid price on the conversion date.
Negative Covenants
. Until (i) the
liquidation value of the Preferred Shares is less than $1,000,000 or (ii) the Forced Conversion Conditions have been met, we may
not take the following actions, among others (the "Restricted Actions"), without the affirmative vote of a majority
of the holders of the Preferred Shares:
(i)
Create, issue, or reclassify any existing shares of capital stock that (a) are senior to, or have
a liquidation preference over, the Preferred Shares, (b) contain any dividend or conversion rights that are preferential to the
dividend rights of the Preferred Shares or (c) are redeemable;
(ii)
Create, incur, assume or suffer to exist any indebtedness or similar obligations, excluding, among
other matters, (a) any indebtedness existing on the initial date of the filing of the Certificate of Designations, (b) indebtedness
to trade creditors incurred in the ordinary course of business, (c) indebtedness associated with acquiring new intellectual property
assets and licenses, so long as the proceeds are going to the party(ies) from which we are acquiring the assets, licenses, and
other properties (vi) any indebtedness not existing at the time hereof and not otherwise permitted not to exceed an aggregate of
$500,000 at any one time;
(iii)
Create or permit to a lien or similar encumberment other than such liens customarily permitted
for our continued operation;
20
(iv)
By merger, consolidation, sale, lease back or other similar transaction (a) sell, transfer or dispose
of 25% or more of our assets, (b) permit the issuance or transfer of more than 25% of our voting control in a single transaction
or series of related transaction or (c) which results in our becoming privately held; and
(vi)
Redeem any shares of our capital stock.
Series B Preferred Shares
The following is a summary of the rights
of the holders of the Series B Preferred Shares. All dollar amounts set out below shall be adjusted proportionally upon the occurrence
of any stock split or common stock dividend
Voting
. Except to the extent required
by law, the holders of the Series B Preferred Shares do not have the right to vote on the matters that the holders of the common
stock have the right to vote upon. The holders of the Series B Preferred Shares may vote upon matters affecting the Series B Preferred
Shares, provided that if the vote concerns all Preferred Shares, the holders of the Series B Preferred Shares shall vote together
with the holders of the Series B Preferred Shares.
Liquidation
. The holders of the
Series B Preferred Shares, together with the holders of the Series B Preferred Shares, shall have a liquidation preference over
the holders of the common stock. Such preference consists of the right to receive upon our voluntary or involuntary liquidation,
dissolution or winding up the liquidation value of each Series B Preferred Share prior to the payment of any amounts to the holders
of the common stock. The liquidation value of each Series B Preferred Share shall be equal to $10 plus any accrued but unpaid dividends
thereon.
Dividends
. Every three months, we
are required to pay each holder of Series B Preferred Shares a dividend equal to 2% of the liquidation value of such shares (which
is equal to 8% on annual basis). Such dividends shall be paid in shares of our common stock in an amount equal to the dollar amount
of such payment divided by the VWAP of our common stock on the date that such dividend payment is due, provided that we may not
issue such shares of common stock if such share issuance would cause the holder to beneficially own more than 9.99% of our common
stock.
Conversion
. Each Series
B Preferred Share may be converted into shares of our common stock in an amount that is equal to the liquidation value divided
by the applicable conversion rate. The conversion rate shall be
the lower of: (a) $2.70 or
(b) 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately preceding the conversion
date, provided that the conversion price may not be less than $1.00; further provided that if the VWAP of our common stock for
any 40 consecutive trading days is less than $1.00 for 30 of those days, then such floor conversion price shall be reduced from
$1.00 to $0.35.
We may force the conversion of
the Series B Preferred Shares if each of the Forced Equity Conditions has been met.
We may not issue those shares
of common stock pursuant to the conversions discussed above that would cause a holder to beneficially own more than 9.99% of our
then outstanding common stock.
If we fail to issue and deliver
Conversion Shares by three trading days after receiving a conversion notice and such holder purchases common stock to deliver in
satisfaction of a sale by such holder of such Conversion Shares, then we shall, at such holder's discretion, either (i) pay cash
to such holder in an amount equal the Buy-In Price, at which point our obligation to deliver issue and deliver such shares
shall terminate, or (ii) promptly honor our obligation to deliver to such Conversion Shares and pay cash to such holder in an amount
equal to the excess (if any) of the Buy-In Price over the product of (A) such Conversion Shares times (B) the closing bid price
on the conversion date.
Negative Covenants
. Until (i) the
liquidation value of the Preferred Shares is less than $1,000,000 or (ii) the Forced Conversion Conditions have been met, we may
not take the Restricted Actions without the affirmative vote of a majority of the holders of the Preferred Shares.
Anti-Takeover Provisions
The provisions of Nevada law and our bylaws
may have the effect of delaying, deferring or preventing another party from acquiring control of the company. These provisions
may discourage and prevent coercive takeover practices and inadequate takeover bids.
21
Nevada Law
Nevada law contains a provision governing
 "acquisition of controlling interest." This law provides generally that any person or entity that acquires 20% or more
of the outstanding voting shares of a publicly-held Nevada corporation in the secondary public or private market may be denied
voting rights with respect to the acquired shares, unless a majority of the disinterested shareholders of the corporation elects
to restore such voting rights in whole or in part. The control share acquisition act provides that a person or entity acquires
 "control shares" whenever it acquires shares that, but for the operation of the control share acquisition act, would
bring its voting power within any of the following three ranges: 20 to 33-1/3%; 33-1/3 to 50%; or more than 50%.
A "control share acquisition"
is generally defined as the direct or indirect acquisition of either ownership or voting power associated with issued and outstanding
control shares. The shareholders or Board of Directors of a corporation may elect to exempt the stock of the corporation from the
provisions of the control share acquisition act through adoption of a provision to that effect in the articles of incorporation
or bylaws of the corporation. Our articles of incorporation and bylaws do not exempt our common stock from the control share acquisition
act.
The control share acquisition act is applicable
only to shares of "Issuing Corporations" as defined by the Nevada law. An Issuing Corporation is a Nevada corporation
which (i) has 200 or more shareholders, with at least 100 of such shareholders being both shareholders of record and residents
of Nevada, and (ii) does business in Nevada directly or through an affiliated corporation.
At this time, we do not believe we have
100 shareholders of record resident of Nevada and we do not conduct business in Nevada directly. Therefore, the provisions of the
control share acquisition act are believed not to apply to acquisitions of our shares and will not until such time as these requirements
have been met. At such time as they may apply, the provisions of the control share acquisition act may discourage companies or
persons interested in acquiring a significant interest in or control of us, regardless of whether such acquisition may be in the
interest of our shareholders.
The Nevada "Combination with Interested
Stockholders Statute" may also have an effect of delaying or making it more difficult to effect a change in control of us.
This statute prevents an "interested stockholder" and a resident domestic Nevada corporation from entering into a "combination,"
unless certain conditions are met. The statute defines "combination" to include any merger or consolidation with an
 "interested stockholder," or any sale, lease, exchange, mortgage, pledge, transfer or other disposition, in one transaction
or a series of transactions with an "interested stockholder" having (i) an aggregate market value equal to 5% or more
of the aggregate market value of the assets of the corporation, (ii) an aggregate market value equal to 5% or more of the aggregate
market value of all outstanding shares of the corporation, or (iii) representing 10% or more of the earning power or net income
of the corporation.
An "interested stockholder"
means the beneficial owner of 10% or more of the voting shares of a resident domestic corporation, or an affiliate or associate
thereof. A corporation affected by the statute may not engage in a "combination" within three years after the interested
stockholder acquires its shares unless the combination or purchase is approved by the Board of Directors before the interested
stockholder acquired such shares. If approval is not obtained, then after the expiration of the three-year period, the business
combination may be consummated with the approval of the Board of Directors or a majority of the voting power held by disinterested
stockholders, or if the consideration to be paid by the interested stockholder is at least equal to the highest of (i) the highest
price per share paid by the interested stockholder within the three years immediately preceding the date of the announcement of
the combination or in the transaction in which he became an interested stockholder, whichever is higher, (ii) the market value
per common share on the date of announcement of the combination or the date the interested stockholder acquired the shares, whichever
is higher, or (iii) if higher for the holders of preferred stock, the highest liquidation value of the preferred stock.
Articles of Incorporation and Bylaws
Our articles of incorporation are silent
as to cumulative voting rights in the election of our directors. Nevada law requires the existence of cumulative voting rights
to be provided for by a corporation's articles of incorporation.  In the event that a few stockholders end up owning
a significant portion of our issued and outstanding common stock, the lack of cumulative voting would make it more difficult for
other stockholders to replace our Board of Directors or for a third party to obtain control of us by replacing our Board of Directors.
Our articles of incorporation and bylaws do not contain any explicit provisions that would have an effect of delaying, deferring
or preventing a change in control of us.
22
The Certificate of Designation for each
of the our Series A Preferred Shares and our Series B Preferred Shares requires that until (i) the liquidation value of the Preferred
Shares is less than $1,000,000 or (ii) the Forced Conversion Conditions have been met, we must obtain the affirmative vote of the
holders of the Preferred Shares prior to the issuance or transfer of more than 25% of our voting control in a single transaction
or series of related transaction.
Transfer Agent and Registrar
The transfer agent and registrar for our
common stock
is VStock Transfer, LLC, 18 Lafayette Place, Woodmere, NY 11598, Phone: (212)
828-8436.
Listing
The shares of our common stock are quoted
on the OTCQB under the symbol QBIO. On April 17, 2020, the last reported sale price per share for our common stock on the OTCQB
as reported was $2.07.
THE PURCHASE
AGREEMENT
The selling stockholder under this
prospectus is offering for resale up to 5,000,000 shares of our common stock, of which 1,836,286 are Series A Preferred Conversion
shares and 3,163,714 are Series B Conversion Shares. On April 6, 2020, we entered into the Purchase Agreement with the selling
stockholder. Pursuant to the Purchase Agreement, the selling stockholder purchased from us 176,566 Series A Preferred Shares and
503,134 Series A Preferred Shares. Simultaneous with entry into the Purchase Agreement, we entered into a registration rights agreement
with the selling stockholder (the "Registration Rights Agreement").
Issuances of the
Preferred Shares and the Conversion Shares will not affect the rights or privileges of our existing stockholders, except that the
liquidation rights of the common stock will be subordinated to the Preferred Shares and the economic and voting interests of each
of our existing stockholders will be diluted as a result of the issuance of the Conversion Shares. Although the number of shares
of Common Stock that our existing stockholders own will not decrease, the shares owned by our existing stockholders will represent
a smaller percentage of our total outstanding shares upon the issuance of any Conversion Shares.
SELLING STOCKHOLDER
Material Relationships
The shares of
common stock being offered by the selling stockholder are a portion of the Conversion Shares. We are registering the shares of
common stock in order to permit the selling stockholder to offer the shares for resale from time to time.
The selling stockholder
has not had a material relationship with us within the past three years except for the entry into the Purchase Agreement and the
Registration Rights Agreement and as noted below:
•
In November 2016, we entered into a convertible debenture
purchase agreement, as amended in March 2017 and October 2017, pursuant to which we sold $4.0 million of convertible debentures
to such selling stockholder between November 2016 and April 2017. Subsequent to their issuance,
(i)
the selling stockholder exchanged an aggregate of
$0.5
million in principal and accrued interest for 162,000 units in an August 2017 private placement. Each unit consisted of one common
stock and one warrant exercisable for five years from the date of date of issuance into a share of our common stock at an exercise
price of $4.50; and
23
(ii)
we amended the Debentures in October 2017 to extend the maturity date from November 30, 2017 to
November 30, 2018 and issued 25,641 restricted shares of our common stock to the holder of the Debentures as consideration for
the extension.
Apart
from the $0.5 million of these debentures exchanged for units in August 2017, all of these convertible debentures were converted
into shares of our common stock;
•
In January 2018, an affiliate of the selling shareholder
purchased 156,250 shares of common stock together with 156,250 warrants to purchase shares of our common stock combined offering
price of $3.20 per share and warrant. This purchase was part of a larger
$5.5 million registered direct offering.
•
We entered into a securities purchase agreement with the
selling stock holder in September 2018 and as amended in September 2019 pursuant to which we sold $4.0 million of convertible debentures
to such selling stockholder T
he conversion price of the convertible debentures was the lower of
(i)
$1.00, (ii) 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately preceding the
conversion date, provided that as long as we are not in default under the
convertible debentures
,
the conversion price may never be less than $0.50, or (
iii) a price agreed to by us and the investor. Additionally, the
maturity date of the convertible debentures was extended to September 21, 2020. Of the convertible debentures sold in this placement,
$3,519,000 of principal and interest were converted into shares of common stock and $766,000 were exchanged for Preferred Shares.
•
On October 11, 2019, we entered into a securities purchase agreement with the selling stockholder,
pursuant to which we sold $500,000 of convertible debentures. The debentures bear interest at the rate of 5.5% per annum. The debentures
are convertible at any time on or prior to maturity at the lower of $1.00 or 93% of the average of the four lowest daily VWAPs
during the 10 consecutive trading days immediately preceding the conversion date, provided that the conversion price could never
be less than $0.50,
or (
iii) a price agreed to by us and the investor.  As of
April 17, 2020, $500,000 of principal and $14,315.07 of accrued and unpaid interest remaining outstanding on these debentures.
•
On December 6, 2019, we entered into a securities purchase agreement with the selling stockholder,
pursuant to which we sold $2,000,000 of convertible debentures. The debentures bore interest at the rate of 5.5% per annum. The
debentures were convertible at any time on or prior to maturity at the lower of $3.00 or 93% of the average of the four lowest
daily VWAPs during the 10 consecutive trading days immediately preceding the conversion date, provided that the conversion price
could never be less than $2.00.  Of the convertible debentures sold in this placement, none of principal and interest were
converted into shares of common stock and $2,031,342 were exchanged for Preferred Shares.
•
On March 31, 2020, we entered into an agreement with the selling stockholder to amend the debentures
that we issued to the selling stockholder in 2018, 2019 and 2020 (the "Debentures"). Pursuant to the terms of the Debentures,
we could not convert any portion of the Debentures or interest thereon that would result in the holder of the Debentures beneficially
owning more than 4.99% of our common stock. In the amendment letter, we mutually agreed with the holder of the Debentures to increase
that limit from 4.99% to 9.99%.
Beneficial Ownership
The table below lists the selling stockholder
and other information regarding the beneficial ownership (as determined under Section 13(d) of the Securities Exchange Act of 1934,
as amended, and the rules and regulations thereunder) of the shares of common stock held by the selling stockholder. The second
column lists the number of shares of common stock beneficially owned by the selling stockholder as of April 17, 2020, assuming
conversion of the Series A Preferred Shares at the conversion price of $1.00 and conversion of the Series B Preferred Shares at
the conversion floor price of $0.35 but not taking account of any limitations on conversion and exercise set forth therein or any
dividends accrued but not paid thereon.
The third column lists the shares of common
stock being offered by this prospectus by the selling stockholder and does not take in account any limitations on conversion of
the Preferred Shares set forth therein.
24
The fourth and sixth columns assume the
sale of all of the shares offered by the selling stockholder pursuant to this prospectus.
Under the terms of the Series A Preferred
Shares and the Series B Preferred Shares, the selling stockholder may not convert the Series A Preferred Shares or the Series B
Preferred Shares to the extent (but only to the extent) such selling stockholder or any of its affiliates would beneficially own
a number of shares of our common stock which would exceed 9.99%. The number of shares in the second column do not reflect these
limitations and, as a result, differ from the beneficial ownership information set out elsewhere in this Prospectus. The selling
stockholder may sell all, some or none of their shares in this offering.  See "Plan of Distribution".
Name of Selling
Stockholder
Number of
Shares of
Common Stock
Owned Prior to
Offering (1)
Maximum
Number of
Shares of
Common Stock
to be Sold
Pursuant to this
Prospectus
Number of
Shares of
Common Stock
Owned After
Offering (2)
Number of
Shares Which
May Be Sold in
This Offering As
A Percentage of
Currently
Outstanding
Shares (3)
Percentage of
Shares of Common Stock
Owned After the
Offering (2)(4)
YA II PN, LTD.(5)
19,359,145
5,000,000
14,359,145
22.3%
52.3%
(1)
Includes (i) 1,871,348 shares of common stock currently held, (ii) 1,765,660 shares of common stock underlying the Series A Preferred Shares beneficially held by such selling stockholder if converted at $1.00, (iii) 14,375,257 shares of common stock underlying the Series B Preferred Shares beneficially held by such selling stockholder if converted at their floor of $0.35, (iv) 318,250 shares of common stock underlying warrants and (v) 1,028,630 shares of common stock underlying outstanding convertible debentures if converted at their floor of $0.50. The amounts reported include common stock that, due to contractual restrictions and the certificates of designation for the Preferred Shares, may not be convertible or exercisable if such conversion would result in the selling stockholder beneficial owning more than 9.99% of the then outstanding shares of common stock.
(2)
Represents the difference between columns two and three and includes securities that, due to contractual restrictions and the certificates of designation for the Preferred Shares, may not be convertible or exercisable if such conversion or exercise would result in the selling stockholder beneficial owning more than 9.99% of the then outstanding shares of common stock.
(3)
If all of the shares are sold pursuant to this offering and the total number of our issued and outstanding common shares otherwise remains unchanged, such shares sold in this offering shall equal approximately 18.2% of the then issued outstanding shares of our common stock.
(4)
Assumes that the total number of our issued and outstanding common shares remains unchanged except for the issuance of the shares being sold pursuant to this prospectus.
(5)
Yorkville Advisors Global, LP ("Yorkville LP") is YA's investment manager and Yorkville Advisors Global II, LLC ("Yorkville LLC") is the General Partner of Yorkville LP. All investment decisions for YA are made by Yorkville LLC's President and Managing Member, Mr. Matthew Beckman. The address of YA is 1012 Springfield Avenue, Mountainside, NJ 07092, Attention: Matthew Beckman.
As of April 17, 2020, our non-affiliates held 19,407,624 shares
of our Common Stock. The shares being offered by the selling stockholder in this prospectus represent approximately 25.8% of our
shares of common stock held by non-affiliates as of April 17, 2020.
Additional Selling Stockholder Information
Number of Shares outstanding prior to the initial issuance of Preferred Shares held by persons other than the Selling Stockholder, affiliates of the Company, and affiliates of the Selling Stockholder
17,566,276
Number of Shares registered for resale by the Selling Stockholder or affiliates of the Selling Stockholder in prior registration statements (1)
4,411,500
Number of Shares registered for resale by the Selling Stockholder or affiliates of the Selling Stockholder that continue to be held by the Selling Stockholder or affiliates of the Selling Stockholder (2)
318,250
Number of Shares that have been sold in registered resale transactions by the Selling Stockholder or affiliates of the Selling Stockholder
1,040,727
Number of Shares registered for resale on behalf of the Selling Stockholder or affiliates of the Selling Stockholder in the current transaction
5,000,000
(1)
Consists of 2,000,000 shares in a registration declared effective in December 2018, 312,500 shares
included in a registration declared effective in January 2018, 324,000 shares included in a registration statement declared effective
in September 2017 and 1,775,000 shares in a registration statement declared effective in April 2016.
(2)
Represents 162,000 shares of common stock underlying warrants issued in July 2017 and 156,250 shares
of common stock underlying warrants issued in January 2018.
25
Potential Profits to Selling Stockholder
The possible profit to the selling shareholder
as a result of the conversion discount depends upon the trading history of our common stock at the time of conversion. If the Preferred
Shares had been converted on the date of their issuance, the profits that the selling stockholder would have realized as a result
of the conversion discount for the shares of common stock underlying the Preferred Shares would have been $3,659,225.  The
selling stockholder's profit as a result of the conversion discount may be greater than or less than that amount.
The Series A Preferred Shares are exercisable
at a fixed conversion price of $1.00. We note that all of the Series A Preferred Shares were exchanged for outstanding convertible
debentures that were exercisable for $1.00 (their maximum conversion price under any circumstances) on the date of exchange. As
a result, we do not believe that the potential profit as calculated below for those Series A Preferred Shares is different from
the amounts that the holder of the convertible debentures would have received on the date of the issuance of the Series A Preferred
Shares if they had converted the convertible notes on those dates. For the purposes of this table, we have used the date of sale
for each tranche of Series A Preferred Shares as the conversion date of such Series A Preferred Shares.
The Series B Preferred Shares are convertible
at a conversion price, depending on the public market for our common stock, between $2.70 and $0.35. As we cannot know what the
conversion price will be for the Series B Preferred Shares, for the purposes of this table, we have used the date of sale for each
tranche of Series B Preferred Shares as the conversion date of such Series B Preferred Shares.
176,566
Series A
Preferred Shares
Issued on
April 7, 2020
303,134
Series B
Preferred Shares
Issued on
April 7, 2020
200,000
Series B
Preferred Shares
Issued on
April 17, 2020
Closing market price per share of the underlying securities on date of issuance
$
2.12
$
2.12
$
2.07
Conversion price per share securities on date of issuance
$
1.00
$
1.4102
$
1.9203
Total possible shares to be received in connection with the conversion of the securities at such conversion price
1,765,660
2,149,582
1,041,504
Combined market price of the total number of underlying shares
$
3,743,199
$
4,557,113
$
2,155,913
Total possible shares to be received and the combined conversion price of the total number of shares
$
1,765,660
$
3,031,340
$
2,000,000
Total possible discount to the market price as of the date of sale of the Preferred Shares
$
1.12
$
0.1984
$
0.1497
Total possible profit that could be realized as a result of the conversion discount as of the date of sale of the Preferred Shares
$
1,977,539
$
1,525,773
$
155,913
26
BUSINESS
We are a commercial stage biotechnology
acceleration and development company focused on acquiring and in-licensing pre-clinical, clinical-stage and approved life sciences
therapeutic products. Currently, we have a portfolio of five therapeutic products, including two FDA approved radiopharmaceuticals
for metastatic cancer bone pain (Strontium-89 and Metastron
TM
) and three development stage products: QBM-001 for rare
pediatric non-verbal autism spectrum disorder, Uttroside-B for liver cancer, and MAN 01 for glaucoma. Our licensed MAN platform
has several potential therapeutics in development in various indications, including vascular and infectious diseases. The infectious
diseases we may ultimately treat include influenza, Coronavirus, Ebola and others. We aim to maximize risk-adjusted returns by
focusing on multiple assets throughout the discovery and development cycle. We expect to benefit from early positioning in illiquid
and/or less well known privately-held assets, thereby enabling us to capitalize on valuation growth as these assets move forward
in their development.
Our mission is to:
(i)
license and acquire pre-commercial
innovative life sciences assets in different stages of development and therapeutic areas from academia or small private companies;
(ii)
license and acquire FDA
approved drugs and medical devices with limited current and commercial activity; and
(iii)
accelerate and advance
our assets to the next value inflection point by providing strategic capital, business development and financial advice and experienced
sector specific advisors.
In 2020, we plan to generate revenue from
our Metastron and Strontium-89 products for pain palliation in bone metastases as well as explore commencing a therapeutic expansion
post-marketing phase 4 trial for Strontium-89. We also intend to file investigational new drug applications, or INDs late in 2020
or early 2021, with the FDA for each of our Uttroside-B and MAN 01 assets for the treatment of liver cancer and glaucoma, respectively.
We also intend to advance our QBM-001 asset to address a non-verbal learning disorder in autistic children.
Following is a summary of our product pipeline.
Our Strategy
Our goal is to become a leading biotechnology
acceleration and development company with a diversified portfolio of therapeutic products commercially available and in development.
To achieve this goal, we are executing on the following strategy:
●
Strategically collaborate or in- and out-license
select programs.
We seek to collaborate or in- and out-license certain potentially
therapeutic candidate products to biotechnology or pharmaceutical companies for preclinical and clinical development and commercialization.
●
Highly leverage external talent and resources.
We plan to maintain and further build our team which is
skilled in evaluating technologies for development and product development towards commercialization. By partnering with industry
specific experts, we are able to identify undervalued assets that we can fund and assist in enhancing inherent value. We plan to
continue to rely on the extensive experience of our management team to execute on our objectives.
27
●
Evaluate commercialization and monetization strategies
on a product-by-product basis in order to maximize the value of our product candidates or future potential products.
As we move our drug candidates through development toward
regulatory approval, we will evaluate several options for each drug candidate's commercialization or monetization strategy.
These options include building our own internal sales force; entering into a joint marketing partnership with another pharmaceutical
or biotechnology company, whereby we jointly sell and market the product; and out-licensing any product that we develop by ourselves
or jointly with another party, whereby another pharmaceutical or biotechnology company sells and markets such product and pays
us a royalty on sales. Our decision will be made separately for each product and will be based on a number of factors including
capital necessary to execute on each option, size of the market to be addressed and terms of potential offers from other pharmaceutical
and biotechnology companies. It is too early for us to know which of these options we will pursue for our drug candidates, assuming
their successful development.
●
Acquire commercially or near-commercially ready
products and build out the current market for such.
In addition to acquiring pre-clinical products, in assembling
a diversified portfolio of healthcare assets, we plan on acquiring assets that are either FDA approved or are reasonably expected
to be FDA approved within 12 months of our acquiring them. We anticipate hiring a contract sales organization to assume the bulk
of the sales and distribution efforts related to any such product.
General Information
We were incorporated in the State of Nevada
on November 22, 2013 under the name ISMO Technology Solutions. On August 5, 2015, we recorded a stock-split effectuated in the
form a stock dividend. The stock dividend was paid at a rate of 1.5 "new" shares for every one issued and outstanding
share held. On June 1, 2015, our Board of Directors determined it was in the best interest of the Company to establish a base of
operations in the biomedical industry. As a result, the Board of Directors approved a change in the Company's name from
 "ISMO Tech Solutions, Inc." to "Q BioMed Inc."  Q BioMed Inc. established its business as a biomedical
acceleration and development company focused on licensing, acquiring and providing strategic resources to life sciences and healthcare
companies.
On October 27, 2015, we filed a Certificate
of Amendment to our Articles of Incorporation with the Secretary of State of Nevada to increase the number of shares of common
stock that we are authorized to issue from 100,000,000 shares to 250,000,000 shares. The Certificate of Amendment affected
no provisions of our Articles of Incorporation other than the number of common stock that we are authorized to issue, and we are
still authorized to issue 100,000,000 shares of preferred stock.
Our Drug Discovery Approach
We aim to acquire, or license and have
assembled, a pipeline of multiple therapeutics in development stages ranging from early pre-clinical to commercial ready. Our model
seeks to diversify risk by broadening the therapeutic areas we work in as well as providing multiple catalysts as we advance assets
through the clinical and regulatory process.
Our mission is to:
(i)
license and acquire pre-commercial innovative life sciences assets in different stages of development and therapeutic areas from academia or small private companies;
(ii)
license and acquire FDA approved drugs and medical devices with limited current and commercial activity; and
(iii)
accelerate and advance our assets to the next value inflection point by providing: (A) strategic capital, (B) business development and financial advice and (C) experienced sector specific advisors.
28
Our Research and Development Activities
As a biomedical acceleration and development
company, research and development is a core aspect of our business. In the fiscal years ended November 30, 2019 and 2018, we have
incurred approximately $3.5 million and $3.2 million, respectively, on research and development activities, and in the three months
ended February 29, 2020 we incurred approximately $0.3 million on such activities.
Metastron™ and Strontium-89 Chloride
USP Injection
We have been working hard to commercialize
Strontium-89 for the non-opiate treatment of metastatic cancer bone pain.
On November 14, 2019, the Department
of Health and Human Services notified us that our supplemental abbreviated new drug application for a new drug product manufacturing
site, IsoTherapeutics Group, LLC, has been approved. IsoTherapeutics is now cleared to manufacture our FDA approved non-opioid
cancer bone pain drug Strontium-89 Chloride USP.
On February 13th we announced the launch
of our FDA approved non-opioid drug Strontium-89 (Strontium Chloride Sr-89 Injection, USP) which has been shown to relieve the
persistent pain associated with cancer that has metastasized to bone. In several multicenter, placebo-controlled trials in cancer
patients with persistent pain after external beam radiation therapy for bone metastases, pain relief occurred in more patients
treated with a single injection of Strontium-89 than in patients treated with an injection of placebo*, with a greater percentage
of patients experiencing pain scores of zero with no use of rescue opioid analgesics. Median duration of pain palliation has been
shown to be 2 to 5 months. Strontium-89 can be redosed every 90 days.
An estimated 10 million people are
living with this condition, and due to the opioid crisis, doctors and patients are looking for an alternative to treat metastatic
cancer associated bone pain. Given that Strontium-89 can be administered every three months and proven effective in approximately
80% of the patients who received the drug, Q BioMed is hopeful that broad market reacceptance will be swift.
We have already received enquiries
and orders from clinics and hospitals around the world. Through our US distribution partner, Jubilant RadiopharmaTM, we have the
capability to reach patients in all 50 states. Our contract manufacturing facility, which is FDA approved to manufacture Strontium-89,
is manufacturing initial commercial-scale quantities, with the first lot produced and shipped in February 2020. The first patient
was dosed in early March, and recent feedback has been that they have had positive results that affirm the outcomes expected from
our clinical data. We look forward to having many more patients benefit from the pain relief that Strontium89 can provide. Manufacturing
will reach full production quantities in April, if no major interruptions occur due to COVID-19 restrictions on people or supply
chain, materials, patients should start to receive treatment from April onwards. Commercial and marketing activities, including
conferences (post COVID-19 restrictions) and sales, will commence concurrent with commercial availability. Strontium89 is reimbursed
by Medicare and most insurance companies.
This is a major milestone for Q BioMed.
We are now a revenue generating entity. We look forward to being able to help serve the unmet needs of the millions of patients
suffering from debilitating pain associated with metastatic cancer in the bone. Years of well documented data prove that Strontium89
benefits this patient population. We believe this drug has a very important role to play as clinicians move toward proven non-opioid
therapeutics for pain palliation.
We plan to launch the drug in global
markets including Europe in 2020 and we have already seen interest from this region. This year Q BioMed will also plan to undertake
further research for Strontium89 for potential label extension into therapeutic use for survival benefit in metastatic bone cancer
through a Phase IV study as well as explore combination studies for enhancing the value proposition of the drug through better
outcomes.
Our leadership team has been expanded
with the addition of a Chief Commercial Officer as well as a Global Head of Regulatory Affairs who will focus on international
regulatory access to markets beyond the US. We have proactively on-boarded our commercial team tasked with infrastructure set-up,
including: medical information and pharmacovigilance, government contracting, marketing, contract sales and telesales. We have
announced a distribution partnership with Jubilant Radiopharma who have all the capabilities we require to access the US market,
including warehousing/inventory management, invoicing and customer service/ordering. Jubilant also has a sales team that calls
on major providers, a national network of nuclear pharmacies in the U.S. and distribution and coverage throughout the U.S.
29
The global demand for access to generic
drugs and non-opioid therapies has given Q BioMed access to a global market much sooner than expected and we continue to be extremely
excited about its prospects to re-establish a deserved niche in the late stage cancer treatment landscape.
Mannin Intellectual Property
On October 29, 2015, we entered into a
Patent and Technology License and Purchase Option Agreement, as amended in April 2019, with Mannin whereby we were granted a worldwide,
exclusive license on, and option to acquire, certain Mannin intellectual property, or IP, within a four-year term.
The Mannin IP is initially focused on developing
a first-in-class eye drop treatment for glaucoma. The technology platform may be expanded in scope beyond ophthalmological uses
and may include cystic kidney disease, cardiovascular diseases and infectious disease. This platform technology has application
in many disease states that result in 'leaky' vessels and the inefficient flow of fluids, like the recent Coronavirus
outbreak. Pursuant to the exclusive license from Mannin, we may purchase the Mannin IP within six years of entry into the agreement
in exchange for investing a minimum of $4,000,000 into the development of the Mannin IP. During the years ended November 30, 2019
and 2018, we respectively incurred approximately $2.1 million and $2.1 million of research and development expenses under the Exclusive
License. The purchase price for the Mannin IP is $30,000,000 less the amount of cash paid by us for development and the value of
the common stock issued to the vendor. We can make this all or part of this payment in stock, provided that such stock does not
represent 15% or more of our issued and outstanding common stock.
In the event that: (i) we do not exercise
the option to purchase the Mannin IP; (ii) we fail to invest the $4,000,000 within six years from the date of the exclusive license;
or (iii) we fail to make a diligent, good faith and commercially reasonable effort to progress the Mannin IP, all Mannin IP shall
revert back to Mannin and we shall be granted the right to collect twice the monies invested through that date of reversion by
way of a royalty along with other consideration which may be perpetual.
On March 26, 2019, we extended the option
period of the initial agreement that was entered into on October 29, 2015. The extension period was extended to October 29, 2021
and 100,000 shares was issued in exchange for the extension.
MAN-01 and GDF15
There are over 60 million patients
worldwide with Primary Open-Angle Glaucoma. MAN-01 aims to reduce the pressure build-up in the eye by assisting with, and correcting,
drainage problems in tiny vessels in the eye called the Schlemm's Canal. MAN-01 is being designed to target these unique
and extremely important vessels, as over 70% of all fluid in the eye flows through the Schlemm's Canal. Currently, the MAN-01
program is finalizing its preclinical lead candidate optimization by completing a series of ophthalmic in vivo studies to demonstrate
efficacy. After successful completion of the in vivo studies, Mannin Research will begin preparing for preclinical toxicology and
filing of its IND. Our research shows that the drug's mechanism of action may ameliorate vessel damage in several other diseases
such as: kidney disease, cardiovascular disease, and against infectious diseases, such as influenza and the current corona virus
outbreak. We believe these programs comprise a multi-disease platform technology that has several valuable applications. Adding
the GDF15 biomarker to our portfolio is a significant step to securing a unique product offering that put precision medicine and
patient specific treatment in the hands of clinicians. GDF15 is a companion diagnostic marker to the MAN-01 drug for determining
the severity of glaucoma using the expression levels of Growth Differentiation Factor 15 (GDF15). Determining the severity of glaucoma
using this biomarker will aid in treatment decisions for patients diagnosed with, and being treated for, glaucoma. Recent buyouts
in the Biotechnology space has us believing that large pharma companies could be looking for valuable assets like this with multiple
downlines because of expiring patient protection on current drugs. Our collaborators at the Washington University in St. Louis
are currently examining the effectiveness of GDF15 as a clinical biomarker in a clinical trial. In parallel, Q BioMed and Mannin
Research are working with the Biointerfaces Institute at McMaster University in Ontario, Canada to develop a GDF15 biomarker diagnostic
kit for monitoring glaucoma severity and progression. The aim is to develop a simple integrated diagnostic test that can be performed
at a physician's office with no external, expensive equipment.
30
The MAN Platform for other indications:
Mannin presented positive data on a
potential new treatment for acute kidney injury (AKI) at the American Society of Nephrology's annual meeting held on November
7, 2019 in Washington DC.
The data presented demonstrates the
Ang-Tie2 signaling pathway as a promising therapeutic target for renal protection from acute kidney injury following ischemic reperfusion.
Ischemia–reperfusion (IR) injury to the kidney occurs in a range of clinically important scenarios including hypotension,
sepsis and in surgical procedures such as cardiac bypass surgery and kidney transplantation, leading to AKI. In-hospital mortality
for patients with AKI has recently been estimated to be between 20 and 25% and mortality rates in excess of 50% have been reported
in critically ill patients with AKI requiring dialysis. For those patients who survive, complications include chronic kidney disease
(CKD) and end-stage renal disease (ESRD); cardiovascular events, and reduced quality of life. In the United States, AKI is associated
with an increase in hospitalization costs that range from $5.4 to $24.0 billion. No effective treatments have been approved by
the FDA. This represents a very significant opportunity to advance a therapeutic in an underserved patient population.
Mannin is developing new therapeutics
to treat a variety of vascular diseases, including the new coronavirus which originated in Wuhan, China, with a rapidly rising
number of deaths and confirmed cases. The Coronavirus has been declared a Global Health Emergency by the World Health Organization
(WHO).
While Mannin is not developing a vaccine
against infectious diseases, it is hoping to develop a new drug which would increase the survival rate of patients by reducing
the severity of disease through enhancement of host-directed therapeutic response.
Mannin recently submitted a grant application
to the U.S. National Institutes of Health for Small Business Technology Transfer Grant Applications for approximately US $0.2 million
for the MAN-11 biologic. The studies will be conducted at Northwestern University to investigate treatment of vascular leakage
to treat sepsis and other infectious diseases. Mannin has also been working with Canada's National Research Council (NRC.CNRC)
since December 2019 to support the development of the biologic. In September 2019, the German state of Saxony awarded Mannin an
approximately US $7.7 million grant to advance the Mannin portfolio of vascular diseases, including development of the biologic.
While we continue to advance all our
assets, our key focus for both capital expense and time is on the commercialization of Strontium-89 Chloride USP Injection. This
is a near-term revenue generator and we believe a significant catalyst and long-term value driver for us.
ASD-002
On April 21, 2017, we entered into a License
Agreement on Patent & Know-How Technology with ASDERA whereby we were granted a worldwide, exclusive, license on certain ASDERA
intellectual property, which was previously referred to as ASD-002 in our pipeline, and was intended to treat Disruption of Active
Language Development (DALD) in toddlers developing Autism Spectrum Disorders. Under that agreement, we paid ASDERA $50,000 and
issued 125,000 shares of our common stock. On November 27, 2019, we notified ASDERA that we considered the Agreement to have been
rescinded retroactively as of April 21, 2017. As a result of such rescission, we believe that we have no continuing material
obligations to ASDERA. However, we will continue to develop unique technologies for the benefit of underserved patient populations.
QBM-001
Among the more than 60,000 US children
who develop autism spectrum disorders, or ASD, every year, approximately 20,000 become nonverbal and will have to rely on assisted
living for the rest of their lives. In parallel to ASD-002, we have been developing a product, QBM-001, intended to treat the rare
condition - pediatric minimally verbal autism. Many of the children who miss this potential treatment window between the age of
2 and 5 years old, may become non-verbal for the rest of their lives. Currently, there is no treatment for this rare disorder.
31
QBM-001 is not intended to treat other
ASDs or to be used beyond the specific group and the estimated treatment window. The "treatment window" results from
independent research that revealed a decreased density in the cortex region of the brain in minimally verbal children with autism,
who were 7 years of age. A biomarker study performed by us has directed us to conclude that QBM-001 cannot be used for other autistic
groups. The study analyzed over 2000 known autistic markers and found two distinct biomarkers for children with pediatric minimally
verbal autism. The biomarkers did not overlap with the high functioning group of autistic children, nor the intermediate group,
which struggles with, but develops limited language. The biomarkers gave us insight into what was wrong with the children and has
given us unique insight on how to ameliorate their condition with the goal of helping them develop the ability to speak.
The biomarker study also led us to evaluate
and identify a rat model that contains the biomarkers and is thus a good model to test QBM-001. In addition, we have access to
cell lines from deceased children who had pediatric minimally verbal autism. QBM-001 consists of a combination of products that
target different mechanisms of action. Having the cell lines and rat model available to us provides us with an excellent preclinical
path to validate the safety and efficacy of QBM-001.
We recently filed an orphan drug application
for our QBM potential drug candidate and plan on filing an IND QBM-001 in 2021.
QBM-001 - Addressing Rare Pediatric
Minimally Verbal Autism
Causes of non-verbal learning disorder
have been linked to several complications that range from a specific mutated gene as with Fragile X Syndrome, Rett Syndrome, Phelan
McDermid Syndrome or autoimmunity, where the body's immune system is attacking parts of the brain. Trauma, microbial infections
and environmental factors have also been linked to non-verbal learning disorder. Ongoing research is helping to further explain
the root cause of why children become non-verbal or minimally verbal.
Cognitive intervention is the only form
for treatment that has shown to help improve speech capability and social interaction in autistic children, however, with minimal
benefit with children with pediatric minimally verbal autism. As intervention does not lead to speech progression, being minimally
verbal carries a lifetime burden of over $5 million per person for cost of care. This is further compounded by additional expenses
during the lifespan of the person due to loss in productivity in addition to severe emotional strain for the child and the parents.
As there are no treatment options for these
patients, we believe there is a significant economic opportunity to bring a drug to market in this indication. The active ingredients
in our compound are well known and have been approved by worldwide regulators for many years. Using a novel delivery and formulation
for the ingredients, we intend to advance this drug through the 505(b)2 pathway.
RGCB and OMRF Intellectual Property
On June 15, 2017, we entered into a Technology
License Agreement with RGCB and OMRF whereby they granted us a worldwide, exclusive, license on intellectual property related to
Uttroside-B.  Uttroside-B is a chemical compound derived from the plant Solanum nigrum Linn, also known as Black Nightshade
or Makoi.  We seek to use the Uttroside-B IP to create a chemotherapeutic agent against liver cancer.
The initial cost to acquire the exclusive
license for Uttroside was $10,000. In addition to royalties based upon net sales of the product candidate, if any, we are required
to make additional payments upon the following milestones:
●
the completion of certain preclinical studies;
●
the filing of an investigational new drug application
with the US Food and Drug Administration or the filing of the equivalent application with an equivalent governmental agency;
●
successful completion of each of Phase I, Phase II
and Phase III clinical trials;
●
FDA approval of the product candidate;
32
●
approval by the foreign equivalent of the FDA of the
product candidate;
●
achieving certain worldwide net sales; and
●
a change of control of our Company.
Subject to the terms of the exclusive license
for Uttroside, we will be in control of the development and commercialization of the product candidate and are responsible for
the costs of such development and commercialization.  We are obligated to undertake a good-faith commitment to (i) fund the
pre-clinical trials and (ii) to initiate a Phase II clinical trial within six years of the date of the Agreement.  Failure
to show a good-faith effort to meet those goals would mean that the exclusive license for Uttroside would revert to the licensors.
UTTROSIDE-B - A Novel Chemotherapeutic
for Liver Cancer
The liver is the football-sized organ in
the upper right area of the belly. Symptoms of liver cancer are uncommon in the early stages. Liver cancer treatments vary, but
may include removal of part of the liver, liver transplant, chemotherapy, and in some cases radiation. Primary liver cancer (hepatocellular
carcinoma) tends to occur in livers damaged by birth defects, alcohol abuse, or chronic infection with diseases such as hepatitis
B and C, hemochromatosis (a hereditary disease associated with too much iron in the liver), and cirrhosis. In the United States,
the average age at onset of liver cancer is 63 years. Men are more likely to develop liver cancer than women, by a ratio of 2 to
1.
The only currently marketed drug is a tryosine
kinase inhibitor antineoplastic agent, sorafinib. Current sales of sorafinib are estimated at $1 billion per year.
Uttroside-B appears to affect phosphorylated
JNK (pro survival signaling) and capcase activity (apoptosis in liver cancer). It is a natural compound fractionated Saponin derived
from the Solarim Nigrum plant. It is a small molecule that showed in early investigation to increase the cytotoxicity of a variety
of liver cancer cell types and importantly to be up to ten times more potent than Sorafenib in pre-clinical studies.
As it is not feasible to use the plant
as the source for a drug, we successfully synthesized the molecule thereby creating an exact replica of the naturally occurring
chemical compound. In a joint research program with India-based Chemveda Life Sciences in 2017, we initiated this very complex
and challenging synthesis program. After 2 years, the exceptional chemists at Chemveda and our scientists, succeeded. The synthetic
molecule has now been tested in comparison to the original plant molecule and the results confirm the same efficacy against the
same liver cancer cell lines. We are now preparing to advance this into the pre-clinical program leading to an IND by the end of
2020 and a proof of concept clinical program in 2021.
Note on COVID-19
To date, the Covid-19 pandemic has not
materially affected our Strontium89 supply chain or production schedule, although a slight delay in supply chain is probable and
expected. However, the pandemic may present an opportunity for Strontium89. In an effort to reduce Covid-19 transmission to at-risk
populations and lower the burden on healthcare systems, systems and organizations are seeking ways to redirect immunocompromised
patients out of hospital settings and hospital care wherever possible. Cancer patients with bone metastases often receive daily
radiation treatments at the hospital. Additionally, those with advanced bone metastases often present at the ER for skeletal-related
events and breakthrough pain. Strontium89 has been used successfully to treat pain associated with bone metastases for over 30
years. As an injection given only every 90 days with significant efficacy levels and relatively minor side effects, Strontium89
is a solution that fulfills many of the needs uniquely represented by the Covid-19 pandemic. However, we are still assessing the
potential for Strontium89 to fulfill this need and do not yet know what the impact of that effort may be.
With respect to Covid-19, we are working
on developing a potential treatment. It is early stage but could be an important tool in treating several infectious diseases that
result in respiratory complications. Our technology partner and licensor, Mannin Research has received requests from, and submitted
responses to, governmental organizations worldwide and philanthropic groups for information about the potential use of its biologic
treatment for Covid-19. The potential treatment is based on the understanding that vascular leakage is a key driver of organ injury
in diseases such as Acute Respiratory Distress Syndrome (ARDS) caused by viruses, including Covid-19. The Angiopoietin-Tie2 signaling
pathway for the treatment of vascular permeability associated with pulmonary edema from respiratory infections like Covid -19,
but also ARDS, SARS, seasonal Influenzas and others. There were 45 million symptomatic flu cases, 810,000 hospitalizations and
61,000 deaths – in the United States alone during the 2017-2018 flu season, according to the CDC. We are in the early stages
of investigations and preclinical evaluation of this potential drug and hope to collaborate with others on a global basis to advance
this program as rapidly as possible. Even if it is ultimately too late to treat this season's Covid-19 outbreak, if effective,
it could be utilized for seasonal influenzas and future similar pandemic viral threats
33
Patents and Intellectual Property Rights
If products we acquired do not have adequate
intellectual protection, we will take the necessary steps to protect our proprietary therapeutic product candidate assets and associated
technologies that are important to our business consisting of seeking and maintaining domestic and international patents. These
may cover our products and compositions, their methods of use and processes for their manufacture and any other inventions that
may be commercially important to the development of our business. We also rely on trade secrets to protect aspects of our business.
Our competitive position depends on our ability to obtain patents on our technologies and our potential products, to defend our
patents, to protect our trade secrets and to operate without infringing valid and enforceable patents or trade secrets of others.
We seek licenses from others as appropriate to enhance or maintain our competitive position.
We hold a license to all intellectual property
related to each of (i) MAN 01, the drug candidate for the treatment of Primary Open Angle Glaucoma and all other potential therapeutics
that may originate from the platform, (ii) QBM-001, the combination drug candidate related to a nonverbal disorder associated with
autism, (iii) SR89, our generic Strontium-89 Chloride product candidate for metastatic cancer bone pain therapy, (iv) Metastron
TM
,
our branded Strontium-89 Chloride product candidate for metastatic cancer bone pain therapy and (iv) the Uttroside-B platform.
We have applied for some patents in our
own right. Most patents and applications are held in the licensors' or inventors' names and are assignable under license
agreements to Q BioMed Inc.
Competition
We operate in highly competitive segments
of the biotechnology and biopharmaceutical markets. We face competition from many different sources, including commercial pharmaceutical
and biotechnology enterprises, academic institutions, government agencies, and private and public research institutions. Our product
candidates, if successfully developed and approved, will compete with established therapies, as well as new treatments that may
be introduced by our competitors. Many of our competitors have significantly greater financial, product development, manufacturing
and marketing resources than us. Large pharmaceutical companies have extensive experience in clinical testing and obtaining regulatory
approval for drugs. In addition, many universities and private and public research institutes are active in the fields in which
we research, some in direct competition with us. We also may compete with these organizations to recruit management, scientists
and clinical development personnel. Smaller or early-stage companies may also prove to be significant competitors, particularly
through collaborative arrangements with large and established companies. New developments, including the development of other biological
and pharmaceutical technologies and methods of treating disease, occur in the pharmaceutical and life sciences industries at a
rapid pace. Developments by competitors may render our product candidates obsolete or noncompetitive. We will also face competition
from these third parties in recruiting and retaining qualified personnel, establishing clinical trial sites and patient registration
for clinical trials and in identifying and in-licensing new product candidates.
Raw Materials and Third-Party Manufacturing
We began commercially producing our sole
product in February 2020, Strontium89. To date, we have sourced all the raw material needed for Strontium89 from Polatom in Poland.
Due to the limited production to date of this product to date, we do not consider it a substantial risk that we have only one supplier
of this raw material. As we ramp up production, we intend to use at least one other supplier of the raw material, but we do not
yet have any such arrangements in place.
34
Likewise, all of our product has been manufactured
by IsoTherapeutics in Houston, Texas. Although we will continue to rely on them for the manufacture of this product, we do not
currently have any intention of finding an additional manufacturer. Were our relationship with IsoTherapeutics to terminate or
they were otherwise unable to manufacture Strontium89, we would not be able to produce more product until a replacement FDA approved
manufacturer is found.
Government Regulation
The clinical development, manufacturing,
labeling, storage, record-keeping, advertising, promotion, import, export, marketing and distribution of our product candidates
are subject to extensive regulation by the FDA in the United States and by comparable health authorities in foreign markets. In
the United States, we are not permitted to market our product candidates until we receive approval of a Biologics License Application
("BLA") from the FDA. The process of obtaining BLA approval is expensive, often takes many years and can vary substantially
based upon the type, complexity and novelty of the products involved. In addition to the significant clinical testing requirements,
our ability to obtain marketing approval for these products depends on obtaining the final results of required non-clinical testing,
including characterization of the manufactured components of our product candidates and validation of our manufacturing processes.
The FDA may determine that our product manufacturing processes, testing procedures or facilities (or those of third parties upon
which we rely) are insufficient to justify approval. Approval policies or regulations may change, and the FDA has substantial discretion
in the pharmaceutical approval process, including the ability to delay, limit or deny approval of a product candidate for many
reasons. Despite the time and expense invested in clinical development of product candidates, regulatory approval is never guaranteed.
The FDA or another regulatory agency can
delay, limit or deny approval of a product candidate for many reasons, including, but not limited to:
●
the FDA or comparable foreign regulatory authorities may disagree with the design or implementation of our clinical trials;
●
we may be unable to demonstrate to the satisfaction of the FDA that a product candidate is safe and effective for any indication;
●
the FDA may not accept clinical data from trials which are conducted by individual investigators or in countries where the standard of care is potentially different from the United States;
●
the results of clinical trials may not meet the level of statistical significance required by the FDA for approval;
●
we may be unable to demonstrate that a product candidate's clinical and other benefits outweigh its safety risks;
●
the FDA may disagree with our interpretation of data from preclinical studies or clinical trials;
●
the FDA may fail to approve our manufacturing processes or facilities or those of third-party manufacturers with which we or our collaborators contract for clinical and commercial supplies; or
●
the approval policies or regulations of the FDA may significantly change in a manner rendering our clinical data insufficient for approval.
With respect to foreign markets, approval
procedures vary among countries and, in addition to the aforementioned risks, can involve additional product testing, administrative
review periods and agreements with pricing authorities. In addition, recent events raising questions about the safety of certain
marketed pharmaceuticals may result in increased cautiousness by the FDA and comparable foreign regulatory authorities in reviewing
new pharmaceuticals based on safety, efficacy or other regulatory considerations and may result in significant delays in obtaining
regulatory approvals. Any delay in obtaining, or inability to obtain, applicable regulatory approvals would prevent us from commercializing
our product candidates.
35
Costs and Effects of Compliance with
Environmental Laws
Federal, state, and international environmental
laws may impose certain costs and restrictions on our business. We do not believe that we have yet spent or lost money due to these
laws and regulations.
Product Liability and Insurance
We face an inherent risk of product liability
exposure related to the testing of our product candidates in human clinical trials and the eventual sale and use of any product
candidates, and claims could be brought against us if use or misuse of one of our product candidates causes, or merely appears
to have caused, personal injury or death. While we have and intend to maintain product liability insurance relating to our clinical
trials, our coverage may not be sufficient to cover claims that may be made against us and we may be unable to maintain such insurance.
Any claims against us, regardless of their merit, could severely harm our financial condition, strain our management and other
resources or destroy the prospects for commercialization of the product which is the subject of any such claim. We are unable to
predict if we will be able to obtain or maintain product liability insurance for any products that may be approved for marketing.
Additionally, we have entered into various agreements where we indemnify third parties for certain claims relating to our product
candidates. These indemnification obligations may require us to pay significant sums of money for claims that are covered by these
indemnifications. We have product liability insurance in place at the time of product launch.
Employees
As of February 29, 2020, we had 1 employee
and 9 management consultants.
Properties
We do not own any properties. We occupy a shared office facility
in Cayman Islands under a license for $30,000 per annum.  The agreement under which we have the license expires in December
2022.
Legal Proceedings
We are not a party to any material pending
legal proceeding, arbitration or governmental investigation, and to the best of our knowledge, no such proceedings have been initiated
against us.
MARKET FOR REGISTRANT'S
COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES
Market Information
Our common stock
is listed on the Over the Counter QB ("OTCQB") under the symbol "QBIO". The market for our common stock
is limited, volatile and sporadic. The following table sets forth, for the periods indicated, the high and low bid prices of our
common stock on the OTCQB as reported by Google Finance. The following quotations reflect inter-dealer prices, without retail mark-up,
markdown, or commissions, and may not reflect actual transactions. Those fiscal quarters during which there were no sales of our
common stock have been labeled as "n/a".
High Bid
Low Bid
Fiscal Year 2020
May 31, 2020 (to April 17, 2020)
$
3.00
$
1.12
February 29, 2020
$
3.45
$
2.41
Fiscal Year 2019
November 30, 2019
$
2.38
$
0.37
August 31, 2019
$
1.64
$
0.91
May 31, 2019
$
2.29
$
1.53
February 28, 2019
$
2.43
$
0.95
Fiscal Year 2018
November 30, 2018
$
3.37
$
1.71
August 31, 2018
$
3.65
$
1.67
May 31, 2018
$
3.95
$
2.85
February 28, 2018
$
5.55
$
2.73
36
The last reported sales price for our shares
on the OTCQB as of April 17, 2020 was $2.07 per share. As of April 17, 2020, we had approximately 134 shareholders of record at
our Transfer Agent.
Dividend Policy
We have never declared or paid any cash
dividends on our common stock.  For the foreseeable future, we will not pay dividends on our common stock but instead we intend
to retain any earnings to finance the development and expansion of our business and do not anticipate paying any cash dividends
on our common stock. The terms of our Preferred Shares prohibit us from declaring any dividends on our common stock without the
affirmative vote of the holders of the Preferred Shares until (i) the liquidation value of the Preferred Shares is less than $1,000,000
or (ii) certain conditions regarding the trading of our common stock have been met. Any future determination to pay dividends will
be at the discretion of the Board of Directors and will depend upon then existing conditions, including our financial condition
and results of operations, capital requirements, contractual restrictions, business prospects and other factors that the board
of directors considers relevant.
Our Series A Preferred Shares carry an
annual dividend equal to 8% of the liquidation value of the Series A Preferred Shares, which liquidation value, subject to customary
adjustments, is equal to the per Series A Preferred Share purchase price of $10. As we have sold 176,566 Series A Preferred Shares
to date for gross proceeds of $1,765,660, we will have to pay $141,253 in dividends on the Series A Preferred Shares if all of
such shares remain outstanding on the one-year anniversary of their issuance.
Our Series B Preferred Shares carry an
annual dividend equal to 8% of the liquidation value of the Series B Preferred Shares, which liquidation value, subject to customary
adjustments, is equal to the per Series B Preferred Share purchase price of $10. As we have sold 503,134 Series B Preferred Shares
to date for gross proceeds of $5,031,340, we will have to pay $402,507 in dividends on the Series B Preferred Shares if all of
such shares remain outstanding on April 6, 2021.
Any dividend due on the Preferred Shares is to be paid in an
amount of common equal to the dollar value of such dividend amount divided by the volume weighted average price ("VWAP")
of our common stock on the date of such dividend payment.
Securities Authorized For Issuance under Compensation Plans
None.
Stock Incentive Plan
None.
Warrants and Convertible Securities
As of April 17, 2020, we had granted
warrants exercisable into 9,785,000 shares of common stock, granted options (not all of which had vested) exercisable into 1,350,000
shares of common stock, issued outstanding notes convertible into a maximum of approximately, 1,250,000 shares of common stock
(assuming conversion at the floor price of the respective notes)  , issued Series A Preferred Shares convertible into
1,765,660 shares of common stock and issued Series B Preferred Shares convertible into 14,375,257 shares of common stock (assuming
conversion at $0.35 and excluding and Preferred Shares that may be paid as dividends). The issuance of any shares of common stock
pursuant to exercise of such options and warrants and the conversion of the debentures and Preferred Shares could be at per share
price below the offering price of shares being acquired in this offering.
Recent Sales of Unregistered Securities
None.
37
MANAGEMENT'S DISCUSSION AND ANALYSIS
OF
FINANCIAL CONDITION AND RESULTS OF OPERATIONS
The following discussion of our financial
condition and results of operations should be read in conjunction with our consolidated financial statements and related notes
included elsewhere in this report. This discussion contains certain forward-looking statements that involve risk and uncertainties.
Our actual results may differ materially from those discussed below. Factors that could cause or contribute to such differences
include, but are not limited to, those identified below and those set forth under the Section entitled "Risk Factors",
and other documents we file with the Securities and Exchange Commission. Historical results are not necessarily indicative of future
results.
Overview
Q BioMed Inc. (or "the Company")
was incorporated in the State of Nevada on November 22, 2013 and is a commercial stage biomedical acceleration and development
company focused on licensing, acquiring and providing strategic resources to life sciences and healthcare companies. We intend
to mitigate risk by acquiring multiple assets over time and across a broad spectrum of healthcare related products, companies and
sectors.  We intend to develop these assets to provide returns via organic growth, revenue production, out-licensing, sale
or spin out.
Since the Company's inception, 4.5 years
ago, we have been busy building significant value ranging from blockbuster potential drugs to imminent revenue producing opportunities.
Our mission is to solve problems by accelerating the development of important therapies and availability of those therapies to
patients.
Metastron™ and Strontium-89 Chloride
USP Injection
We have been working hard to commercialize
Strontium-89 for the non-opiate treatment of metastatic cancer bone pain. We have settled our litigation with BioNucleonics Inc.
and now have outright ownership of the generic Strontium-89 Chloride drug, which is FDA approved. We also own Metastron™,
the branded drug, purchased from GE Healthcare in November of 2018. As a result, we now control significant market share for this
injectable non-opioid metastatic cancer palliation drug in North America and much of the world.
On November 14, 2019, the Department of
Health and Human Services notified us that our supplemental abbreviated new drug application for a new drug product manufacturing
site, IsoTherapeutics Group, LLC, has been approved. IsoTherapeutics is now cleared to manufacture our FDA approved non-opioid
cancer bone pain drug Strontium-89 Chloride USP.
On February 13th we announced the launch
of our FDA approved non-opioid drug Strontium-89 (Strontium Chloride Sr-89 Injection, USP) which has been shown to relieve the
persistent pain associated with cancer that has metastasized to bone. In  several multicenter, placebo-controlled trials in
cancer patients with persistent pain after external beam radiation therapy for bone metastases, pain relief occurred in more patients
treated with a single injection of Strontium-89 than in patients treated with an injection of placebo*, with a greater percentage
of patients experiencing pain scores of zero with no use of rescue opioid analgesics. Median duration of pain palliation has been
shown to be 2 to 5 months. Strontium-89 can be redosed every 90 days.
An estimated 10 million people are living
with this condition, and due to the opioid crisis, doctors and patients are looking for an alternative to treat metastatic cancer
associated bone pain. Given that Strontium-89 can be administered every three months and proven effective in approximately 80%
of the patients who received the drug, Q BioMed is hopeful that broad market reacceptance will be swift.
We have already received orders from clinics
and hospitals. Through our distribution partner, Jubilant RadiopharmaTM, we have the capability to reach patients in all 50 states.
Our contract manufacturing facility, which is FDA approved to manufacture Strontium-89, is manufacturing initial commercial-scale
quantities, with the first set of doses to be shipped in February 2020. Manufacturing will reach full production quantities in
March and patients should start to receive treatment from March onwards. Commercial and marketing activities, including conferences
and sales, will commence concurrent with commercial availability. Strontium-89 is reimbursed by Medicare and most insurance companies.
38
This is a major milestone for Q BioMed.
We are now a revenue generating entity. This was a goal we set for ourselves when we founded the company almost 5 years ago. The
journey to producing a commercial drug has not been easy, but we are now there. It's a great achievement and a testament to
all those who have helped get us to this point. We look forward to being able to help serve the unmet needs of the millions of
patients suffering from debilitating pain associated with metastatic cancer in the bone. Years of well documented data prove that
Strontium-89 benefits this patient population. We believe this drug has a very important role to play as clinicians move toward
proven non-opioid therapeutics for pain palliation.
We plan to launch the drug in global markets
including Europe in 2020. Q BioMed is also planning further research for Strontium-89 for potential label extension into therapeutic
use for survival benefit in metastatic bone cancer through a Phase IV study.
In anticipation of the approval, we have
proactively on-boarded our commercial team tasked with infrastructure set-up, including: medical information and pharmacovigilance,
government contracting, marketing, contract sales and telesales. We have announced a distribution partnership with Julibilant Radiopharma
who have all the capabilities we require to access the US market, including warehousing/inventory management, invoicing and customer
service/ordering. It also has a sales team that calls on major providers, a national network of nuclear pharmacies in the U.S.
and distribution and coverage throughout the U.S. We have completed a reimbursement landscape and set our pricing strategy. Our
scientific platform is complete which is informing a creative advertising campaign to coincide with the commercial launch of our
product. We are assembling a world class scientific advisory board specific to this product to assist in market access and phase
4 clinical trial planning.
Our Strontium-89 radiopharmaceutical drug
addresses an underserved patient group in the cancer pain palliation market, but also has a significant opportunity to expand into
a much larger market through our planned phase IV clinical trial designed to expand the label from a pain palliation to a cancer
therapeutic. A similar radiopharmaceutical with a much narrower indication in metastatic disease, but with survival benefits (two
months), was acquired by Bayer for $2.9 billion in 2013 and is expected to have sales exceeding $700 million this year.
The acquisition of Metastron and global
demand for access to generic drugs and non-opioid therapies has given Q BioMed access to a global market much sooner than expected
and we continue to be extremely excited about its prospects to re-establish a deserved niche in the late stage cancer treatment
landscape.
QBM001
There is currently no treatment for this
20,000 US and 250,000 worldwide subgroup of autistic children that are born each year and become minimally verbal or non-verbal.
We recently filed for Orphan Drug Designation with the FDA and look forward to working with the regulators on this application.
We worked with 7 centers of excellence for autism to define a differential diagnosis for our targeted subgroup, and all are on
board. We completed a biomarker study that allows us to better define which children should be included in our planned trial. The
biomarker also provided insight into how to improve the dosing. We believe that a very targeted population with an improved, targeted
dose, will allow our planned trials to be smaller and increase the likelihood of being successful. Having also identified an autism
animal model with our biomarkers will also now accelerate our path to IND in 2021.
Uttroside-B
Over 40,000 liver cancer patients in the
US are diagnosed every year, and the total diagnoses per year has increased by 3% each year over the last 15 years. Each patient
has a life expectancy of less than four months. Our initial data from both animals and cell lines suggests that our developing
molecule could be very effective - as much as 10 times more effective than current treatments. As a result, we intend to bring
this product to a proof of concept trial. If demonstrated, we will actively seek partnerships in order to realize a return on our
investment. We believe that we are the only entity to have successfully synthesized Uttroside B and have filed a patent for the
synthesis. The synthesized product is now being tested and has shown exact comparison to the natural product in the same liver
cancer cell lines.
39
MAN-01 and GDF15
There are over 60 million patients worldwide
with Primary Open-Angle Glaucoma. MAN-01 aims to reduce the pressure build-up in the eye by assisting with, and correcting, drainage
problems in tiny vessels in the eye called the Schlemm's Canal. MAN-01 is being designed to target these unique and extremely
important vessels, as over 70% of all fluid in the eye flows through the Schlemm's Canal. Currently, the MAN-01 program is
finalizing its preclinical lead candidate optimization by completing a series of ophthalmic in vivo studies to demonstrate efficacy.
After successful completion of the in vivo studies, Mannin Research will begin preparing for preclinical toxicology and filing
of its IND. Our research shows that the drug's mechanism of action may ameliorate vessel damage in several other diseases
such as: kidney disease, cardiovascular disease, and against infectious diseases, such as influenza and the current corona virus
outbreak. We believe these programs comprise a multi-disease platform technology that has several valuable applications. Adding
the GDF15 biomarker to our portfolio is a significant step to securing a unique product offering that put precision medicine and
patient specific treatment in the hands of clinicians. GDF15 is a companion diagnostic marker to the MAN-01 drug for determining
the severity of glaucoma using the expression levels of Growth Differentiation Factor 15 (GDF15). Determining the severity of glaucoma
using this biomarker will aid in treatment decisions for patients diagnosed with, and being treated for, glaucoma. Recent buyouts
in the Biotechnology space has us believing that large pharma companies could be looking for valuable assets like this with multiple
downlines because of expiring patient protection on current drugs. Our collaborators at the Washington University in St. Louis
are currently examining the effectiveness of GDF15 as a clinical biomarker in a clinical trial. In parallel, Q BioMed and Mannin
Research are working with the Biointerfaces Institute at McMaster University in Ontario, Canada to develop a GDF15 biomarker diagnostic
kit for monitoring glaucoma severity and progression. The aim is to develop a simple integrated diagnostic test that can be performed
at a physician's office with no external, expensive equipment.
The MAN Platform for other indications:
Mannin presented positive data on a potential
new treatment for acute kidney injury (AKI) at the American Society for Nephrology 2019 Annual Meeting on November 7 in Washington
DC.
The data presented demonstrates the Ang-Tie2
signaling pathway as a promising therapeutic target for renal protection from acute kidney injury following ischemic reperfusion.
Ischemia–reperfusion (IR) injury to the kidney occurs in a range of clinically important scenarios including hypotension,
sepsis and in surgical procedures such as cardiac bypass surgery and kidney transplantation, leading to AKI. In-hospital mortality
for patients with AKI has recently been estimated to be between 20 and 25% and mortality rates in excess of 50% have been reported
in critically ill patients with AKI requiring dialysis. For those patients who survive, complications include chronic kidney disease
(CKD) and end-stage renal disease (ESRD); cardiovascular events, and reduced quality of life.  In the United States, AKI is
associated with an increase in hospitalization costs that range from $5.4 to $24.0 billion. No effective treatments have been approved
by the FDA. This represents a very significant opportunity to advance a therapeutic in an underserved patient population.
Mannin is developing new therapeutics to
treat a variety of vascular diseases, including the new coronavirus which originated in Wuhan, China, with a rapidly rising number
of deaths and confirmed cases. The Coronavirus has been declared a Global Health Emergency by the World Health Organization (WHO).
While Mannin is not generating a vaccine
against infectious diseases, it is developing a new drug that may increase the survival rate of patients by reducing the severity
of disease through enhancement of host-directed therapeutic response.
Mannin recently submitted a grant application
to the U.S. National Institutes of Health for Small Business Technology Transfer Grant Applications for approximately US $0.2 million
for the MAN-11 biologic. The studies will be conducted at Northwestern University to investigate treatment of vascular leakage
to treat sepsis and other infectious diseases. Mannin is also working with Canada's National Research Council (NRC.CNRC)
since December 2019 to support the development of the biologic. In September 2019, the German state of Saxony awarded Mannin an
approximately US $7.7 million grant to advance the Mannin portfolio of vascular diseases, including development of the biologic.
40
While we continue to advance all our assets,
our key focus for both capital expense and time is on the commercialization of Strontium-89 Chloride USP Injection. This is a near-term
revenue generator and we believe a significant catalyst and long-term value driver for us.
Financial Overview
Critical Accounting Policies and Estimates
Our management's discussion and analysis
of our financial condition and results of operations is based on our audited consolidated financial statements, which have been
prepared in accordance with United States generally accepted accounting principles ("U.S. GAAP"). The preparation of
the consolidated financial statements requires us to make estimates and assumptions that affect the reported amounts of assets
and liabilities and the disclosure of contingent assets and liabilities at the date of the consolidated financial statements, as
well as the reported revenue generated and expenses incurred during the reporting periods. Our estimates are based on our historical
experience and on various other factors that we believe are reasonable under the circumstances, the results of which form the basis
for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual
results may differ from these estimates under different assumptions or conditions and any such differences may be material. We
believe that the accounting policies discussed below are critical to understanding our historical and future performance, as these
policies relate to the more significant areas involving management's judgments and estimates.
Fair value of financial instruments
Fair value estimates discussed herein are
based upon certain market assumptions and pertinent information available to management as of November 30, 2019 and 2018.  The
respective carrying value of certain on-balance-sheet financial instruments approximated their fair values. These financial instruments
include cash and accounts payable. Fair values were assumed to approximate carrying values for cash and accounts payable because
they are short term in nature.
FASB Accounting Standards Codification
(ASC) 820 "
Fair Value Measurements and Disclosures
" (ASC 820) defines fair value as the exchange price that
would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for
the asset or liability in an orderly transaction between market participants on the measurement date. ASC 820 also establishes
a fair value hierarchy that distinguishes between (1) market participant assumptions developed based on market data obtained from
independent sources (observable inputs) and (2) an entity's own assumptions about market participant assumptions developed
based on the best information available in the circumstances (unobservable inputs). The fair value hierarchy consists of three
broad levels, which gives the highest priority to unadjusted quoted prices in active markets for identical assets or liabilities
(Level 1) and the lowest priority to unobservable inputs (Level 3). The three levels of the fair value hierarchy are described
below:
●
Level 1
: The preferred inputs to valuation
efforts are "quoted prices in active markets for identical assets or liabilities," with the caveat that the reporting
entity must have access to that market.  Information at this level is based on direct observations of transactions involving
the same assets and liabilities, not assumptions, and thus offers superior reliability. However, relatively few items, especially
physical assets, actually trade in active markets.
●
Level 2
: FASB acknowledged that active markets
for identical assets and liabilities are relatively uncommon and, even when they do exist, they may be too thin to provide reliable
information. To deal with this shortage of direct data, the board provided a second level of inputs that can be applied in three
situations.
●
Level 3
: If inputs from levels 1 and 2 are
not available, FASB acknowledges that fair value measures of many assets and liabilities are less precise. The board describes
Level 3 inputs as "unobservable," and limits their use by saying they "shall be used to measure fair value to
the extent that observable inputs are not available." This category allows "for situations in which there is little,
if any, market activity for the asset or liability at the measurement date". Earlier in the standard, FASB explains that
 "observable inputs" are gathered from sources other than the reporting company and that they are expected to reflect
assumptions made by market participants.
41
Fair value measurements discussed herein
are based upon certain market assumptions and pertinent information available to management as of and during the years ended November
30, 2019 and 2018. The respective carrying value of cash and accounts payable approximated their fair values as they are short
term in nature.
Intangible Assets
Intangible assets subject to amortization
include acquired intellectual property for a marketable product acquired in November 2018. The intellectual property is being amortized
over the estimated life remaining at the time of acquisition, which is 10 years.
Intangible assets are monitored for potential
impairment whenever events or circumstances indicate that the carrying amount may not be recoverable and are also reviewed annually
to determine whether any impairment is necessary. The annual review of intangible assets is performed via a two-step process. First,
a qualitative assessment is performed to determine if it is more likely than not that the intangible asset is impaired. If required,
a quantitative assessment is performed and, if necessary, impairment is recorded.
Debt Issuance Costs
Direct costs incurred to issue non-revolving
debt instruments are recognized as a reduction to the related debt balance in the accompanying Consolidated Balance Sheets and
amortized to interest expense over the contractual term of the related debt using the effective interest method.
Embedded Conversion Features
We evaluate embedded conversion features
within convertible debt to determine whether the embedded conversion feature(s) should be bifurcated from the host instrument and
accounted for as a derivative at fair value with changes in fair value recorded in the Statement of Operations.  If the conversion
feature does not require recognition of a bifurcated derivative, the convertible debt instrument is evaluated for consideration
of any beneficial conversion feature ("BCF") requiring separate recognition. When we record a BCF, the intrinsic value
of the BCF is recorded as a debt discount against the face amount of the respective debt instrument (offset to additional paid-in
capital) and amortized to interest expense over the life of the debt.
Derivative Financial Instruments
We do not use derivative instruments to
hedge exposures to cash flow, market, or foreign currency risks. We evaluate all of our financial instruments, including issued
stock purchase warrants, to determine if such instruments are derivatives or contain features that qualify as embedded derivatives.
For derivative financial instruments that are accounted for as liabilities, the derivative instrument is initially recorded at
its fair value and is then re-valued at each reporting date, with changes in the fair value reported in the Statement of Operations.
Depending on the features of the derivative financial instrument, we use either the Black-Scholes option-pricing model or a binomial
model to value the derivative instruments at inception and subsequent valuation dates.  The classification of derivative instruments,
including whether such instruments should be recorded as liabilities or as equity, is re-assessed at the end of each reporting
period.
Stock Based Compensation
Effective December 1, 2018, the Company
adopted ASU 2018-07, by which the accounting for share-based payments to non-employees and employees is substantially aligned.
Non-employee share-based payment awards are measured at grant-date fair value of the equity instruments that the Company is obligated
to issue when the good has been delivered or the service has been rendered and any other conditions necessary to earn the right
to benefit from the instruments have been satisfied. There was no cumulative effect of the adoption of this standard.
Share-based compensation cost is recorded
for all option grants and awards of non-vested stock based on the grant date fair value of the award and is recognized over the
service period required for the award. Prior to December 1, 2018, share-based compensation cost for non-employees was remeasured
over the vesting term as earned.
42
Stock-based compensation expense
is recognized in the consolidated financial statements based on the fair value of the awards granted. Stock-based compensation cost
is measured at the grant date based on the fair value of the award and is recognized as expense over the requisite service
period, which generally represents the vesting period. We calculate the fair value of stock options using the Black-Scholes
option-pricing model at grant date.
Research and Development
We expense the cost of research and development
as incurred.  Research and development expenses comprise costs incurred in funding research and development activities,
license fees, and other external costs. Nonrefundable advance payments for goods and services that will be used in future research
and development activities are expensed when the activity is performed or when the goods have been received, rather than when payment
is made, in accordance with ASC 730,
Research and Development
.
Income Taxes
Deferred tax assets and liabilities are
computed based upon the difference between the financial statement and income tax basis of assets and liabilities using the enacted
marginal tax rate applicable when the related asset or liability is expected to be realized or settled.  Deferred income tax
expenses or benefits are based on the changes in the asset or liability each period.  If available evidence suggests that
it is more likely than not that some portion or all of the deferred tax assets will not be realized, a valuation allowance is required
to reduce the deferred tax assets to the amount that is more likely than not to be realized. Future changes in such valuation allowance
are included in the provision for deferred income taxes in the period of change.
Deferred income taxes may arise from temporary
differences resulting from income and expense items reported for financial accounting and tax purposes in different periods.  Deferred
taxes are classified as current or non-current, depending on the classification of assets and liabilities to which they relate.
  Deferred taxes arising from temporary differences that are not related to an asset or liability are classified as current
or non-current depending on the periods in which the temporary differences are expected to reverse.
We apply a more-likely-than-not recognition
threshold for all tax uncertainties, which only allows the recognition of those tax benefits that have a greater than fifty
percent likelihood of being sustained upon examination by the taxing authorities. As of November 30, 2019, we reviewed our
tax positions and determined there were no outstanding, or retroactive tax positions with less than a 50% likelihood of being sustained
upon examination by the taxing authorities, therefore this standard has not had a material effect on us.
Our policy for recording interest and penalties
associated with audits is to record such expense as a component of income tax expense. There were no amounts accrued for penalties
or interest during the years ended November 30, 2019. Management is currently unaware of any issues under review that could
result in significant payments, accruals or material deviations from our position.
Recent accounting pronouncements
For a summary of recent accounting pronouncements
applicable to our consolidated financial statements, see Note 3, Summary of Significant Accounting Policies, in Part II, Item 8,
Notes to Consolidated Financial Statements.
Results of Operation
For the fiscal years ended November
30, 2019 and 2018
For the year ended
2019
2018
Operating expenses:
General and administrative expenses
$
4,480,577
$
5,781,613
Research and development expenses
3,539,381
3,238,060
Total operating expenses
8,019,958
9,019,673
Other expenses:
Interest expense
1,460,384
162,104
Change in fair value of embedded derivatives
208,240
89,000
Loss on conversion of debt
591,148
-
Total other expenses
2,259,772
251,104
Net loss
$
(10,279,730
)
$
(9,270,777
)
43
Operating expenses
We incur various costs and expenses in
the execution of our business. The decrease in operating expenses was mainly due to less professional and research & development
fees incurred in connection with the license agreements with Mannin and Washington University.
Interest expenses
The following table summarizes interest expenses
incurred during the year ended November 30, 2019 and 2018, respectively:
For the year ended November 30,
2019
2018
Interest expense based on the coupon interest rate of the outstanding debt
$
328,000
$
30,000
Accretion of debt discount
1,001,000
132,000
Interest expense related to deferral fee
131,000
-
Total interest expense
$
1,460,00
$
162,000
Change in fair value of embedded derivatives
We recognized a loss of approximately $0.2
million and $0.1 million resulting from the change in fair value of embedded contingent put options in convertible debentures during
the year ended November 30, 2019 and 2018, respectively. The increase is due to an increased in our outstanding convertible debentures
balance at November 30, 2019 compared to November 30, 2018.
Loss on conversion of debt
During the year ended November 30, 2019,
we recognized a loss of approximately $0.6 resulting from conversion of partial 2018 Debentures and 2019 Debenture.
Net loss
In the years ended November 30, 2019
and 2018, we incurred net losses of approximately $10.3 million and $9.3 million, respectively. Our management expects to continue
to incur net losses for the foreseeable future, due to our need to continue to continue to establish a broader pipeline of assets,
expenditure on R&D and implement other aspects of our business plan.
For the three months ended February
29, 2020 and February 28, 2019
For the Three Months ended
February 29, 2020
February 28, 2019
Operating expenses:
General and administrative expenses
$
5,570,000
$
1,243,000
Research and development expenses
263,000
814,000
Total operating expenses
5,833,000
2,057,000
Other (income) expenses:
Interest expense
198,000
291,000
Change in fair value of embedded derivatives
(89,000
)
27,000
Total other expenses
109,000
318,000
Net loss
$
(5,942,000
)
$
(2,375,000
)
44
Operating expenses
We incur various costs and expenses in
the execution of our business. The increase in operating expenses was mainly due to an increased charge in stock-based compensation
compared to last year. We recorded approximately $4.5 million and $0.5 million of stock-based compensation under general and administrative
expense during the three months ended February 29, 2020 and February 28, 2019, respectively.
Interest expenses
During the three months ended February
29, 2020, interest expense decreased to approximately $0.2 million from $0.3 million in the prior year.
The following table summarizes interest expenses
incurred during the three months ended February 29, 2020 and February 28, 2019, respectively:
For the Three Months ended
February 29, 2020
February 28, 2019
Interest expense based on the coupon interest rate of the outstanding debt
$
107,000
$
55,000
Accretion of debt discount
91,000
236,000
Total interest expense
$
198,000
$
291,000
Change in fair value of embedded derivatives
We recognized approximately $89,000 gain
and $27,000 loss resulting from the change in fair value of embedded contingent put options in convertible notes during the three
months ended February 29, 2020 and February 28, 2019, respectively. The fluctuation is mainly due the change of stock price during
the reporting periods.
Net loss
During the three months ended February
29, 2020 and February 28, 2019, we incurred net losses of approximately $5.9 million and $2.4 million, respectively.  Our
management expects to continue to incur net losses for the foreseeable future, due to our need to continue to establish a broader
pipeline of assets, expenditure on R&D and implement other aspects of our business plan.
Liquidity and Capital Resources
We prepared the accompanying consolidated
financial statements assuming that we will continue as a going concern, which contemplates the realization of assets and liquidation
of liabilities in the normal course of business.
We have not yet established an ongoing
source of revenues and must cover our operating through debt and equity financings to allow us to continue as a going concern.
We had approximately $0.2 million and $0.7 million in cash as of November 30, 2019 and February 29, 2020, respectively. Our ability
to continue as a going concern depends on the ability to obtain adequate capital to fund operating losses until we generate adequate
cash flows from operations to fund our operating costs and obligations. If we are unable to obtain adequate capital, we could be
forced to cease operations.
45
We depend upon our ability, and will continue
to attempt, to secure equity and/or debt financing. We cannot be certain that additional funding will be available on acceptable
terms, or at all. Our management determined that there was substantial doubt about our ability to continue as a going concern
within one year after the consolidated financial statements were issued, and management's concerns about our ability to continue
as a going concern within the year following this report persist.
The accompanying consolidated financial
statements do not include any adjustments relating to the recoverability and classification of recorded asset amounts or amounts
and classification of liabilities that might result from this uncertainty.
For the fiscal years ended November
30, 2019 and 2018
Cash Flows
The following table sets forth the significant
sources and uses of cash for the periods addressed in this report:
For the year ended
2019
2018
Net cash (used in) provided by:
Operating activities
$
(4,105,000
)
$
(6,451,000
)
Investing activities
-
(500,000
)
Financing activities
1,593,000
8,810,000
Net (decrease) increase in cash
$
(2,512,000
)
$
1,860,000
Net cash used in operating activities was
approximately $4.1 million for the year ended November 30, 2019 as compared to approximately $6.5 million for the year ended November
30, 2018.  The decrease in net cash used in operating activities results from the net loss of approximately $10.3 million
for the year ended November 30, 2019, partially offset by aggregate non-cash expenses of approximately $4.7 million. The increase
in net cash used in operating activities results from the net loss of approximately $9.3 million for the year ended November 30,
2018, partially offset by aggregate non-cash expenses of approximately $2.9 million.
Net cash used in investing activities was
$0.5 million for the year ended November 30, 2018, resulting from purchase of intangible assets.
Net cash provided by financing activities
was approximately $1.6 million for the year ended November 30, 2019, resulting from proceeds received from the issuance of convertible
debentures payable of approximately $1.0 million and the issuance of common stock and warrants of approximately $0.6 million. Net
cash provided by financing activities was approximately $8.8 million for the year ended November 30, 2018, resulting from proceeds
received from the issuance of convertible debentures payable of approximately $3.9 million and the issuance of common stock and
warrants of approximately $5.4 million, offset by offering costs of approximately $0.5 million.
For the three months ended February
29, 2020 and February 28, 2019
Cash Flows
The following table sets forth the significant
sources and uses of cash for the periods addressed in this report:
For the Three Months ended
February 29, 2020
February 28, 2019
Net cash (used in) provided by:
Operating activities
$
(1,397,000
)
$
(1,371,000
)
Financing activities
1,965,000
—
Net increase (decrease) in cash
$
568,000
$
(1,371,000
)
46
Net cash used in operating activities was
approximately $1.4 million for the three months ended February 29, 2020 as compared to approximately $1.4 million for the three
months ended February 28, 2019.
Net cash provided by financing activities
was approximately $2.0 million for the three months ended February 29, 2020, resulting from proceeds received from issuance of
two debentures.  There were no activities for the three months ended February 28, 2019.
Obligations and Commitments
Advisory Agreements
We entered into customary consulting arrangements
with various counterparties to provide consulting services, business development and investor relations services, pursuant to which
we agreed to issue shares of common stock as services are received.
Office Facility Agreement
In December 2016, the Subsidiary entered
into a license to occupy a shared office facility in Cayman Islands for $30,000 per annum.  The initial term of the agreement ended
in December 2019 and the Company renewed the agreement for another three years with the same terms.
This agreement does not identify a specific
asset and does not convey the use of substantially all of the shared office capacity. As such, this agreement does not contain
a lease under ASC 842. The Company recognizes monthly license payments as incurred over the term of the arrangement.
The associated expense is classified within
general and administrative expenses.
License Agreements
Mannin
On October 29, 2015, we entered into a
Patent and Technology License and Purchase Option Agreement ("Exclusive License") with a vendor whereby we were granted
a worldwide, exclusive, license on, and option to, acquire certain intellectual property ("Mannin IP") which initially
focused on developing a first-in-class eye drop treatment for glaucoma within the four-year term of the Exclusive License.
On March 26, 2019, we entered into an amendment
to the Patent and Technology License and Purchase Option Agreement that it initially entered into with Mannin Research Inc. on
October 29, 2015 (the "Mannin Agreement"). Under such amendment, the term of the option granted under the Mannin Agreement
was extended to October 29, 2021 in exchange for our issuing 100,000 shares to Mannin Research Inc. on April 9, 2019.
During the years ended November 30, 2019
and 2018, we respectively incurred approximately $2.1 million in research and development expenses to fund the costs of development
of the eye drop treatment for glaucoma pursuant to the Exclusive License.
Washington University
On March 9, 2019, we entered into
an Exclusive License Agreement with Washington University for license of a diagnostic marker for determining the severity of glaucoma
using the expression levels of Growth Differentiation Factor 15. The agreement calls for us to pay an initial fee of approximately
$88,000, pay annual maintenance fees ranging from $15,000 to $75,000, make additional payments upon the following milestones:
•
The first commercial sale of a companion diagnostic
product;
•
Initiation of a clinical trial for a diagnostic product
to support FDA PMA or 510(k) regulatory approval or the foreign equivalent;
•
PMA or 510(k) regulatory approval by the FDA or the foreign equivalent; and
•
The first commercial sale of a diagnostic product.
47
In additional to the above payments, royalty
payments based upon sales of a companion diagnostic product or diagnostic product are required.
Related Party Transactions
We entered into consulting agreements with
certain management personnel and stockholders for consulting and legal services.  Consulting and legal expenses resulting
from such agreements were included within general and administrative expenses in the accompanying Consolidated Statements of Operations
as follows:
For the fiscal years ended November
30, 2019 and 2018
For the year ended November 30,
2019
2018
Consulting and legal expenses
$
532,000
$
295,000
For the three months ended February
29, 2020 and February 28, 2019
For the Three Months ended
February 29, 2020
February 28, 2019
Consulting and legal expenses
$
105,000
$
102,000
Off-Balance Sheet Arrangements
We do not have any off-balance sheet arrangements.
MANAGEMENT
Our directors and executive officers and their respective ages
as of the date of this prospectus are as follows:
Name
Age
Position with the Company
Denis Corin
46
Chief Executive Officer, Director (Chairman)
William Rosenstadt
51
Chief Legal Officer, Director
Rick Panicucci
59
Director
The following describes the business experience
of each of our directors and executive officers, including other directorships held in reporting companies:
Mr. Denis Corin
has been the
Chief Executive Officer and Chairman of the Board of the Company since April 21, 2015. Mr. Corin is a management consultant. He
has worked for large pharmaceutical (Novartis) and diagnostic instrumentation companies (Beckman Coulter) in their sales organizations
responsible for sales in multi-product disciplines including pharmaceuticals and diagnostics and diagnostic automation equipment.
After Novartis and Beckman Coulter, he served as Director of Investor Relations in the small-cap biotech arena at MIV Therapeutics
Inc, a company specializing in next generation drug delivery and drug eluting cardiovascular stents. Mr. Corin served as an executive
and on the board of directors of TapImmune Inc. from July 2009 to May 2012. He received his Bachelor's degrees in Economics
and Marketing from the University of Natal, South Africa in 1996.
Mr. William Rosenstadt
was
appointed as the Company's general counsel and member of the Company's board of directors on June 1, 2015. Mr. Rosenstadt
is a practicing corporate and securities lawyer. He is also the founding member and the managing partner of Ortoli Rosenstadt LLP,
a law firm, formed in 2006. Mr. Rosenstadt received his Juris Doctorate from Benjamin N. Cardozo School of Law in 1995 and his
Bachelor of Arts from Syracuse University in 1990.
48
Dr. Rick Panicucci
was appointed
as a member of the Company's board of directors on February 13, 2018. Dr. Panicucci specializes in the early stages of drug
discovery for various companies. His responsibilities include solid state chemistry and formulation development of all small molecule
therapeutics in early development and developing novel drug delivery technologies for small molecules and large molecules including
siRNA. Since September 2015, Dr. Panicucci has been working with one of our licensors, Mannin Research Inc., in the development
plan for MAN-01, a novel drug candidate that we license for the topical treatment of open-angle glaucoma. Since February 2015,
he has served as the Vice President of Pharmaceutical Development at WuXi AppTec, where he is responsible for providing scientific
leadership in the areas of Developability, Formulation Development and GMP Manufacturing. Prior to WuXi he held the position of
Global Head of Chemical and Pharmaceutical Profiling (CPP) at Novartis from 2004 to 2015, where he led the development and implementation
of innovative dosage form designs and continuous manufacturing paradigms. He has also held positions as the Director of Formulation
Development at Vertex Pharmaceuticals and Senior Scientist at Biogen.
Dr. Panicucci received his Ph.D. in Physical
Organic Chemistry at the University of Toronto and has two postdoctoral fellowships at University of California at Santa Barbara
and the Ontario Cancer Institute. Dr. Panicucci will continue advise on the scientific and commercial development of our MAN-01
glaucoma drug with Mannin Research Inc. He will also now provide insight and guidance on all our pipeline assets.
In connection with his service as a director,
we have entered into an agreement with Dr. Panicucci pursuant to which he will earn options to acquire up to 50,000 shares of our
common stock. The options will vest in quarterly installments of 12,500 each and are exercisable for 5 years at $3.00 per option.
Term of Office
Our directors are appointed for a one-year
term to hold office until the next annual general meeting of our stockholders or until they resign or are removed from the board
in accordance with our bylaws. Our officers are appointed by our Board of Directors and hold office until they resign or are removed
from office by the Board of Directors.
Significant Employees
Our sole employee is our Chief Executive
Officer.
Audit Committee
We do not currently have an audit committee.
Compensation Committee
We do not currently have compensation committee.
Involvement in Certain Legal Proceedings
None of our directors, executive officers
or control persons has been involved in any of the following events during the past five years: (i) any bankruptcy petition filed
by or against any business of which such person was a general partner or executive officer either at the time of the bankruptcy
or within two years prior to that time; (ii) any conviction in a criminal proceeding or being subject to a pending criminal proceeding
(excluding traffic violations and other minor offences); (iii) being subject to any order, judgment or decree, not subsequently
reversed, suspended or vacated, of any court of competent jurisdiction, permanently or temporarily enjoining, barring, suspending
or otherwise limiting his involvement in any type of business, securities or banking activities; or (iv) being found by a court
of competent jurisdiction (in a civil action), the SEC or the Commodity Futures Trading Commission to have violated a federal or
state securities or commodities law, and the judgment has not been reversed, suspended or vacated.
49
Code of Ethics
We have not adopted a code of corporate
conduct.
Compliance with Section 16(a) of
the Exchange Act
Section 16(a)
of the Exchange Act requires our directors and officers, and the persons who beneficially own more than 10% of our common stock,
to file reports of ownership and changes in ownership with the SEC. Copies of all filed reports are required to be furnished
to us pursuant to Rule 16a-3 promulgated under the Exchange Act. Based solely on the reports received by us and on the representations
of the reporting persons, we believe that these persons have complied with all applicable filing requirements during the year ended
November 30, 2019.
TRANSACTIONS WITH RELATED PERSONS
We entered into consulting agreements with
certain management personnel and stockholders for consulting and legal services. Consulting and legal expenses resulting from
such agreements were approximately $0.4 million and $0.3 million for the year ended November 30, 2019 and 2018, respectively,
and $0.1 million for the three months ended February 29, 2020. We do not have any obligations outstanding to other persons
who beneficially own more than 10% of our common stock.
EXECUTIVE COMPENSATION
Our directors do not receive any stated
salary for their services as directors or members of committees of the board of directors, but have received stock options for
director services and, by resolution of the board, a fixed fee may be allowed for attendance at each meeting. Directors may also
serve the Company in other capacities as an officer, agent or otherwise, and may receive compensation for their services in such
other capacity. No such fees have been paid to any director since incorporation.  Reasonable travel expenses are reimbursed.
Summary Compensation Table
The following table sets forth information
concerning all cash compensation awarded to, earned by or paid to all individuals serving as the Company's principal executive
officers during the last two completed fiscal years ended November 30, 2019 and 2018, respectively and all non-cash compensation
awarded to those same individuals in those time periods.
Name and Principal Position
Year
Salary
Awards
Stock Awards
Warrant Awards
Option Awards
All Other Compensation
Total
Denis Corin
(2)
2019
$
320,000
$
-
$
20,000
$
30,000
$
206,000
$
-
$
576,000
Chief Executive Officer
2018
$
240,000
$
-
$
-
$
-
$
438,000
$
-
$
678,000
William Rosenstadt
(3)
2019
$
-
$
-
$
72,000
$
99,000
$
206,000
$
313,000
$
690,000
General Counsel and Director
2018
$
-
$
-
$
59,000
$
-
$
438,000
$
331,000
$
828,000
(1)
The amounts
    represent fees paid or accrued by us to the executive officers during the past year pursuant to various employment and consulting
    services agreements, as between us and the executive officers, which are described below. Our executive officers are also
    reimbursed for any out-of-pocket expenses incurred in connection with corporate duties. We presently have no pension, health,
    annuity, insurance, profit sharing or similar benefit plans.
(2)
Mr. Denis Corin was
    appointed as Chief Executive Officer and Director on April 21, 2015.
(3)
Mr. William Rosenstadt
    was appointed as General Counsel and Director on June 5, 2015.
(4)
Mr.
        Corin was granted 40,000 shares of common stock on November 25, 2019 with grant date fair value of $20,000.
Mr.
        Rosenstadt was granted 115,761 shares of common stock on October 15, 2019 with grant date fair value of $72,000.
Mr.
        Rosenstadt was granted 20,000 shares of common stock on September 21, 2018 with grant date fair value of $59,000.
(5)
500,000
        warrants held by Mr. Corin was amended on October 1, 2019. The $30,000 represents the incremental value received by Mr.
        Corin.
Mr.
        Rosenstadt was granted 173,641 warrants on October 15, 2019 with grant date fair value of $59,000.
800,000
        warrants held by Mr. Rosenstadt was amended on October 1, 2019. The $40,000 represents the incremental value received
        by Mr. Rosenstadt.
(6)
On
        May 31, 2019, Mr. Corin and Mr. Rosenstadt were each granted 150,000 stock options. The fair value on the grant date was
        $206,000, which included $40,000 incremental value from the amendment on October 1, 2019.
On
        June 1, 2018, Mr. Corin and Mr. Rosenstadt were each granted 150,000 stock options. The fair value on the grant date was
        $438,000.
50
The following table sets forth information
as of November 30, 2020 relating to outstanding equity awards for each Named Executive Officer:
Outstanding Equity Awards at Year End
Table
Name
Number of
Securities
Underlying
Unexercised
Options
(exercisable)
Number of
Securities
Underlying
Unexercised
Options
(unexercisable)
Number of
Securities
Underlying
Unexercised
Unearned
Options
Option
Exercise
Price
Option
Expiration
Date
Denis Corin
150,000
-
-
$
1.45
July 15, 2021
500,000
-
-
$
June 5, 2022
150,000
-
-
$
May 31, 2023
150,000
-
-
$
June 5. 2024
750,000
-
$
February 10, 2025
William Rosenstadt
250,000
-
-
$
1.45
January 4, 2021
200,000
-
-
$
July 15, 2021
500,000
-
-
$
June 5, 2022
150,000
-
-
$
May 31, 2023
150,000
-
-
$
June 5, 2024
173,641
-
$
October 16, 2024
750,000
-
$
February 10, 2025
225,000
-
$
2.12
April 6, 2020
Rick Panicucci
50,000
-
-
$
February 13, 2023
150,000
-
-
$
May 31, 2023
150,000
-
-
$
June 5, 2024
60,000
-
90,000
$
December 5, 2024
2,610,000
1,673,641
90,000
BENEFICIAL OWNERSHIP OF PRINCIPAL STOCKHOLDERS,
OFFICERS AND DIRECTORS
Security Ownership of Certain Beneficial Owners and Management
The following table sets forth, as of February
25, 2019, certain information regarding the ownership of our common stock by (i) each person known by us to be the beneficial owner
of more than 5% of our outstanding shares of common stock, (ii) each of our directors, (iii) our Principal Executive Officer and
(iv) all of our executive officers and directors as a group. Unless otherwise indicated, the address of each person shown is c/o
Ortoli Rosenstadt LLP, 366 Madison Avenue 3rd Floor, New York, New York 10017. Beneficial ownership, for purposes of this table,
includes options to purchase common stock that are either currently exercisable or will be exercisable within 60 days of the date
of this annual report.
51
Name and Address of Beneficial Owner
Amount and
Nature of
Beneficial
Owner (1)
Percent of
Class (2)
Directors and Officers:
Denis Corin (3)
3,391,800
14.5
%
William Rosenstadt (4)
2,042,222
8.5
%
Rick Panicucci
140,000
0.2
%
Directors and Officers as a Group (3)(4)
5,544,022
20.0
%
Major Stockholders:
Ari Jatwes (5)
1,375,000
5.9
%
(1)
Under Rule 13d-3, a beneficial owner of a security includes any person who, directly or indirectly, through any contract, arrangement, understanding, relationship, or otherwise has or shares: (1) voting power, which includes the power to vote, or to direct the voting of shares; and (ii) investment power, which includes the power to dispose or direct the disposition of shares. Certain shares may be deemed to be beneficially owned by more than one person (if, for example, persons share the power to vote or the power to dispose of the shares. In addition, shares are deemed to be beneficially owned by a person if the person has the right to acquire the shares (for example, upon the exercise of an option) within 60 days of the date as of which the information is provided. In computing the percentage ownership of any person, the amount of shares outstanding is deemed to include the amount of shares beneficially owned by such person (and only such person) by reason of these acquisition rights. As a result, the percentage of outstanding shares of any person as shown in this table does not necessarily reflect the person's actual ownership or voting power with respect to the number of shares of common stock actually outstanding as of February 25, 2019.
(2)
This percentage is based upon 22,468,185
        shares of common stock outstanding as of April 17, 2020 and any warrants or options exercisable by such person within 60 days of
        the date as of which the information is provided.
(3)
Includes (i) 150,000 five-year warrants
        issued in July 2016 for director fees, (ii) 350,000 five-year warrants issued in June 5, 2017 as a bonus for officer services through
        the date thereof, (iii) 150,000 five-year options issued on June 5, 2017 for services as a director and officer through June 1,
        2018, (iv) 150,000 five-year options issued in June 2018 for services as a director and officer through June 1, 2019 and (v) 150,000
        five-year options issued in June 2019 for services as a director and officer through June 1, 2020, all of which are exercisable
        within 60 days of the date as of which the information is provided.
(4)
Includes (i) 250,000 five-year warrants
        issued in January 2016 to the law firm at Mr. Rosenstadt is a partner, (ii) 50,000 five-year warrants issued in July 2016 which
        were issued to the law firm at Mr. Rosenstadt is a partner, (iii) 150,000 five-year warrants issued in July 15, 2016 for director
        fees through June 1, 2017, (iv) 350,000 five-year warrants issued in June 2017 as a bonus for officer services through the date
        thereof, (v) 150,000 five-year options issued on June 5, 2017 for services as a director and officer through June 1, 2018, (vi)
        150,000 five-year options issued in June 2018 for services as a director and officer through June 1, 2019 and (vii) 150,000 five-year
        options issued in June 2019 for services as a director and officer through June 1, 2020, all of which are exercisable within 60
        days of the date as of which the information is provided.
(5)
Includes (i) 75,000 warrants issued in July 2016, (ii) 85,000 warrants issued in June 2017, (iii) 150,000 options issued in June 2017, (iv) 50,000 options issued in July 2018, (v) 50,000 options issued in September 2019 and (vi) 300,000 warrants issued in February 2020.
There are no arrangements or understanding
among the parties set out above or their respective associates or affiliates concerning election of directors or any other matters
which may require shareholder approval.
Changes in Control
We are unaware of any contract, or other
arrangement or provision, the operation of which may at a subsequent date result in a change of control of our Company.
52
LEGAL MATTERS
The legality and validity of the securities
offered from time to time under this prospectus will be passed upon by Ortoli Rosenstadt LLP. William Rosenstadt, our general counsel
and one of our directors is the managing partner of Ortoli Rosenstadt LLP.
DISCLOSURE OF COMMISSION POSITION ON
INDEMNIFICATION FOR SECURITIES ACT LIABILITIES
Our by-laws require us to indemnify any
of our officers or directors, and certain other persons, under certain circumstances against all expenses and liabilities incurred
or suffered by such persons because of a lawsuit or similar proceeding to which the person is made a party by reason of a his being
a director or officer of the Company or our subsidiaries, unless that indemnification is prohibited by law. We may also purchase
and maintain insurance for the benefit of any officer which may cover claims for which we could not indemnify a director or officer.
We have been advised that in the opinion of the Securities and Exchange Commission, indemnification of our officers, directors
and controlling persons under these provisions, or otherwise, is against public policy and is unenforceable.
Insofar as indemnification for liabilities
arising under the Securities Act of 1933, as amended (the "Securities Act"), may be permitted to directors, officers
or persons controlling us pursuant to the foregoing provisions, or otherwise, we have been advised that in the opinion of the Securities
and Exchange Commission, such indemnification is against public policy as expressed in the Securities Act, and is therefore unenforceable.
EXPERTS
Our financial statements as of and for
the years ended November 30, 2019 and 2018
have been included in the registration statement
in reliance upon the report, which includes an explanatory paragraph as to our ability to continue as a going concern, of Marcum
LLP, independent registered public accounting firm, and upon the authority of said firm as experts in accounting and auditing.
WHERE YOU CAN FIND ADDITIONAL INFORMATION
We are a reporting company and file annual,
quarterly and current reports, proxy statements and other information with the SEC. We have filed with the SEC a registration statement
on Form S-1 under the Securities Act with respect to the securities we are offering under this prospectus. This prospectus does
not contain all of the information set forth in the registration statement and the exhibits to the registration statement. For
further information with respect to us and the securities we are offering under this prospectus, we refer you to the registration
statement and the exhibits and schedules filed as a part of the registration statement. You may read and copy the registration
statement, as well as our reports, proxy statements and other information, at the SEC's Public Reference Room at 100 F Street,
N.E., Washington, D.C. 20549. You can request copies of these documents by writing to the SEC and paying a fee for the copying
cost. Please call the SEC at 1-800-SEC-0330 for more information about the operation of the Public Reference Room. The SEC maintains
an internet site that contains reports, proxy and information statements, and other information regarding issuers that file electronically
with the SEC, where our SEC filings are also available. The address of the SEC's web site is http://www.sec.gov.
53
Q BIOMED INC.
INDEX TO CONSOLIDATED FINANCIAL STATEMENTS
Page No.
Report of Independent Registered Public Accounting Firm
F-2
Consolidated Financial Statements:
Consolidated Balance Sheets as of November 30, 2019 and 2018
F-3
Consolidated Statements of Operations for the years ended November 30, 2019 and 2018
F-4
Consolidated Statements of Changes in Shareholders' Equity (Deficit) for the years ended November 30, 2019 and 2018
F-5
Consolidated Statements of Cash Flows for the years ended November 30, 2019 and 2018
F-6
Notes to Consolidated Financial Statements
F-7
Consolidated Balance Sheets as of February 29, 2020
F-21
Consolidated Statements of Operations for the quarter ended February 29, 2020
F-22
Consolidated Statements of Changes in Shareholders' Equity (Deficit) for the quarter ended February 29, 2020
F-23
Consolidated Statements of Cash Flows for the quarter ended February 29, 2020
F-24
Notes to Consolidated Financial Statements
F-25
F-
1
REPORT OF INDEPENDENT REGISTERED PUBLIC
ACCOUNTING FIRM
To
the
Shareholders and Board of Directors of
Q
BioMed
Inc.
Opinion on the Financial Statements
We
have audited the accompanying consolidated balance sheets of Q BioMed
Inc. (the "Company") as of November 30,
2019 and 2018, the related consolidated statements of operations
,
stockholders' equity and cash flows for each of
the two years in the period ended November 30, 2019, and the related notes (collectively referred to as the "financial statements").
In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company as of
November 30, 2019 and 2018, and the results of its operations and its cash flows for each of the two years in the period ended
November 30, 2019, in conformity with accounting principles generally accepted in the United States of America.
Explanatory Paragraph – Going Concern
The
accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern.
As more fully described in Note 2, the Company has a significant working capital deficiency, has incurred significant losses and
needs to raise additional funds to meet its obligations and sustain its operations. These conditions raise substantial doubt about
the Company's ability to continue as a going concern. Management's plans in regard to these matters are also described in Note
2. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.
Basis for Opinion
These
financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on the Company's
financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight
Board (United States) ("PCAOB") and are required to be independent with respect to the Company in accordance with the
U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.
We
conducted our audits in accordance with the standards of the
PCAOB. Those standards require that we plan and perform the
audits to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to
error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial
reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not
for the purpose of expressing an opinion on the effectiveness of the Company's internal control over financial reporting. Accordingly,
we express no such opinion.
Our
audits included performing procedures to assess the risks of material misstatement of the financial statements, whether
due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis,
evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting
principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements.
We believe that our audits provide a reasonable basis for our opinion.
/s/
Marcum
llp
Marcum
llp
We have served as the Company's auditor since 2015
.
New York, NY
February 28, 2020
F-
2
Q BIOMED INC.
Consolidated Balance Sheets
As of November 30,
2019
2018
ASSETS
Current assets:
Cash
$
172,636
$
2,684,413
Prepaid expenses and other current assets
17,662
12,500
Total current assets
190,298
2,696,913
Intangible assets, net
450,000
500,000
Total Assets
$
640,298
$
3,196,913
LIABILITIES AND STOCKHOLDERS' DEFICIT
Current liabilities:
Accounts payable
$
652,051
$
172,628
Accrued expenses
1,145,660
219,602
Accrued expenses - related party
7,500
7,500
Accrued interest payable
189,801
29,639
Convertible note payable, net
3,243,292
-
Total current liabilities
5,238,304
429,369
Long-term liabilities:
Convertible notes payable, net
447,335
2,873,272
Total long term liabilities
447,335
2,873,272
Total Liabilities
5,685,639
3,302,641
Commitments and Contingencies (Note 7)
Stockholders' Deficit:
Preferred stock, $0.001 par value; 100,000,000 shares authorized; no shares issued and outstanding as of November 30, 2019 and 2018
-
-
Common stock, $0.001 par value; 250,000,000 shares authorized; 19,709,068 and 14,290,236 shares issued and outstanding as of November 30, 2019 and 2018, respectively
19,709
14,290
Additional paid-in capital
37,328,827
31,994,129
Accumulated deficit
(42,393,877
)
(32,114,147
)
Total Stockholders' Deficit
(5,045,341
)
(105,728
)
Total Liabilities and Stockholders' Deficit
$
640,298
$
3,196,913
The accompanying notes are an integral part
of these consolidated financial statements.
F-
3
Q BIOMED INC.
Consolidated Statements of Operations
For the year ended
November 30,
2019
2018
Operating expenses:
General and administrative expenses
$
4,480,577
$
5,781,613
Research and development expenses
3,539,381
3,238,060
Total operating expenses
8,019,958
9,019,673
Other expenses:
Interest expense
1,460,384
162,104
Change in fair value of embedded derivatives
208,240
89,000
Loss on conversion of debt
591,148
-
Total other expenses
2,259,772
251,104
Net loss
$
(10,279,730
)
$
(9,270,777
)
Net loss per share - basic and diluted
$
(0.68
)
$
(0.67
)
Weighted average shares outstanding, basic and diluted
15,040,513
13,735,134
The accompanying notes are an integral part
of these consolidated financial statements.
F-
4
Q BIOMED INC.
Consolidated Statement of Changes in
Shareholders' Equity (Deficit)
Common
                                         Stock
Additional
                                         Paid in
Accumulated
Total
Stockholders
'
Shares
Amount
Capital
Deficit
Equity
                                         (Deficit)
Balance as of December
    1, 2017
12,206,409
$
12,206
$
23,187,408
$
(22,843,370
)
$
356,244
Issuance of common stock,
    warrants and options for services
296,952
297
2,650,180
-
2,650,477
Issuance of common stock
    and warrants for cash, net of offering costs
1,711,875
1,712
4,943,539
-
4,945,251
Issuance of common stock
    in connection with issuance of convertible notes
75,000
75
222,675
-
222,750
Beneficial conversion
    feature in connection with issuance of convertible notes
-
-
990,327
-
990,327
Net loss
-
-
-
(9,270,777
)
(9,270,777
)
Balance as of November 30, 2018
14,290,236
14,290
31,994,129
(32,114,147
)
(105,728
)
Issuance of common stock
    and warrants for cash, net of offering costs
1,521,602
1,522
621,728
-
623,250
Share based compensation
    for services
1,577,131
1,577
2,494,719
-
2,496,296
Issuance of common stock
    to convert notes payable
2,320,099
2,320
2,218,251
-
2,220,571
Net loss
-
-
-
(10,279,730
)
(10,279,730
)
Balance as of November 30, 2019
19,709,068
$
19,709
$
37,328,827
$
(42,393,877
)
$
(5,045,341
)
The accompanying notes are an integral part
of these consolidated financial statements.
F-
5
Q BIOMED INC.
Consolidated Statement of Cash Flows
For the year ended
November 30,
2019
2018
Cash flows from operating activities:
Net loss
$
(10,279,730
)
$
(9,270,777
)
Adjustments to reconcile net loss to net cash used in operating activities
Share based compensation for services
2,496,296
2,650,477
Change in fair value of embedded conversion option
208,240
89,000
Accretion of debt discount
1,001,153
132,349
Amortization expense
50,000
-
Loss on conversion of debt
591,148
-
Non-cash interest expense
131,265
-
Changes in operating assets and liabilities:
Prepaid expenses
(5,162
)
(10,000
)
Accounts payable and accrued expenses
1,405,481
(71,309
)
Accrued interest payable
296,282
29,639
Net cash used in operating activities
(4,105,027
)
(6,450,621
)
Cash flows from investing activities:
Purchase of intangible assets
-
(500,000
)
Net cash used in investing activities
-
(500,000
)
Cash flows from financing activities:
Proceeds received from issuance of convertible note, net of original issuance discount and lender's fees
970,000
3,865,000
Proceeds received for issuance of common stock and warrants, net of offering costs
623,250
4,945,251
Net cash provided by financing activities
1,593,250
8,810,251
Net (decrease) increase in cash
(2,511,777
)
1,859,630
Cash at beginning of the year
2,684,413
824,783
Cash at end of the year
$
172,636
$
2,684,413
Supplemental disclosures:
Cash paid for interest
$
31,524
$
-
Cash paid for income taxes
$
-
$
-
Supplemental disclosures for noncash investing and financing activities:
Issuance of common stock to convert notes payable and accrued interest
$
1,493,511
$
-
Issuance of common stock in connection with issuance convertible notes
$
-
$
222,750
The accompanying notes are an integral part
of these consolidated financial statements.
F-
6
Q BIOMED INC.
Notes to Consolidated Financial Statements
Note 1 – Organization of the Company and
Description of the Business
Q BioMed Inc. ("Q BioMed" or
 "the Company"), incorporated in the State of Nevada on November 22, 2013, is a biomedical acceleration and development
company focused on licensing, acquiring and providing strategic resources to life sciences and healthcare companies. Q BioMed intends
to mitigate risk by acquiring multiple assets over time and across a broad spectrum of healthcare related products, companies and
sectors.  The Company intends to develop these assets to provide returns via organic growth, revenue production, out-licensing,
sale or spinoff new public companies.
On
December 7, 2016, the Company formed its wholly-owned subsidiary in Cayman Islands, "Q BioMed Cayman SEZC"
(the
 "Subsidiary"). On August 13, 2019, the Company formed its wholly-owned subsidiary in Germany, "QBMG Q BioMed
Germany UG". There are no activities through November 30, 2019.
The accompanying consolidated financial
statements include the accounts of the Company's wholly-owned subsidiary.  All intercompany balances and transactions
have been eliminated in consolidation.
Note 2 – Basis of
Presentation and Going Concern
The accompanying consolidated financial
statements are presented in U.S. dollars and have been prepared in accordance with accounting principles generally accepted in
the United States of America ("US GAAP") and pursuant to the accounting and disclosure rules and regulations of the
U.S. Securities and Exchange Commission (the "SEC").
The Company currently operates in one business
segment focusing on licensing, acquiring and providing strategic resources to life sciences and healthcare companies. The Company
is not organized by market and is managed and operated as one business. A single management team reports to the chief operating
decision maker, the Chief Executive Officer, who comprehensively manages the entire business. The Company does not currently operate
any separate lines of business.
Going Concern
The accompanying consolidated financial
statements are prepared assuming the Company will continue as a going concern, which contemplates the realization of assets and
liquidation of liabilities in the normal course of business.
The Company has and is expected to incur
net losses and cash outflows from operations in pursuit of extracting value from its acquired intellectual property. These matters,
amongst others, raise doubt about the Company's ability to continue as a going concern.
The
Company has not generated any revenue from operations since inception and has limited assets upon which to commence its business
operations.
Management anticipates that the Company will have to raise additional funds and/or generate revenue
from drug sales within twelve months to continue operations. Additional funding will be needed to implement the Company's
business plan that includes various expenses such as fulfilling our obligations under licensing agreements, legal, operational
set-up, general and administrative, marketing, employee salaries and other related start-up expenses. Obtaining additional funding
will be subject to a number of factors, including general market conditions, investor acceptance of our business plan and initial
results from our business operations. These factors may impact the timing, amount, terms or conditions of additional financing
available to us. If the Company is unable to raise sufficient funds, management will be forced to scale back the Company's
operations or cease its operations.
Management has determined that there is
substantial doubt about the Company's ability to continue as a going concern within one year after the consolidated financial statements
are issued. The accompanying consolidated financial statements do not include any adjustments relating to the recoverability
and classification of recorded asset amounts, or amounts and classification of liabilities that might result from this uncertainty.
Note 3 – Summary of Significant
Accounting Policies
Use of estimates
The preparation of consolidated financial
statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts
of assets and liabilities and disclosure of contingent assets and liabilities at the date of the consolidated financial statements
and the reported amounts of revenue and expenses during the reporting period.  Actual results may differ from those estimates,
and such differences may be material to the consolidated financial statements. The more significant estimates and assumptions by
management include among others: the valuation allowance of deferred tax assets resulting from net operating losses, the valuation
of warrants on the Company's stock and the valuation of embedded derivatives within the Company's convertible notes
payable.
F-
7
Concentration of Credit Risk
Financial
instruments that potentially subject the Company to concentration of credit risk consist of cash accounts in a financial institution
which, at times
are insured by the Federal Deposit Insurance Corporation ("FDIC") up to $250,000. At November
30, 2019, the Company had a cash balance that is insured by the FDIC limit. The Company had not experienced losses on these
accounts and management believes the Company is not exposed to significant risks on such accounts.
Fair value of financial instruments
Fair value is defined as the price that
would be received for sale of an asset or paid for transfer of a liability, in an orderly transaction between market participants
at the measurement date.  U.S. GAAP establishes a three-tier fair value hierarchy, which prioritizes the inputs used
in measuring fair value.  The hierarchy gives the highest priority to unadjusted quoted prices in active markets for
identical assets or liabilities (Level 1 measurements) and the lowest priority to unobservable inputs (Level 3 measurements).  These
tiers include:
●
Level 1, defined as observable inputs such as quoted prices for identical instruments in active markets;
●
Level 2, defined as inputs other than quoted prices in active markets that are either directly or indirectly observable such as quoted prices for similar instruments in active markets or quoted prices for identical or similar instruments in markets that are not active; and
●
Level 3, defined as unobservable inputs in which little or no market data exists, therefore requiring an entity to develop its own assumptions, such as valuations derived from valuation techniques in which one or more significant inputs or significant value drivers are unobservable.
Fair
value measurements discussed herein are based upon certain market assumptions and pertinent information available to management
as of and during the years ended November 30,
2019 and 2018.  The respective carrying value of cash and accounts payable
approximated their fair values as they are short term in nature.
Intangible Assets
Intangible
assets subject to amortization include acquired intellectual property for a marketable product acquired in November 2018. The intellectual
property is being amortized over the estimated life remaining at the time of acquisition, which is 10 years
.
Intangible assets are monitored for potential
impairment whenever events or circumstances indicate that the carrying amount may not be recoverable and are also reviewed annually
to determine whether any impairment is necessary. The annual review of intangible assets is performed via a two-step process. First,
a qualitative assessment is performed to determine if it is more likely than not that the intangible asset is impaired. If required,
a quantitative assessment is performed and, if necessary, impairment is recorded.
Debt Issuance Costs
Direct costs incurred to issue non-revolving
debt instruments are recognized as a reduction to the related debt balance in the accompanying Consolidated Balance Sheets and
amortized to interest expense over the contractual term of the related debt using the effective interest method.
Embedded Conversion Features
The Company evaluates embedded conversion
features within convertible debt to determine whether the embedded conversion feature(s) should be bifurcated from the host instrument
and accounted for as a derivative at fair value with changes in fair value recorded in the Statement of Operations.
  If the conversion feature does not require recognition of a bifurcated derivative, the convertible debt instrument
is evaluated for consideration of any beneficial conversion feature ("BCF") requiring separate recognition. When the
Company records a BCF, the intrinsic value of the BCF is recorded as a debt discount against the face amount of the respective
debt instrument (offset to additional paid-in capital) and amortized to interest expense over the life of the debt.
Derivative Financial Instruments
The Company does not use derivative instruments
to hedge exposures to cash flow, market, or foreign currency risks. The Company evaluates all of its financial instruments,
including issued stock purchase warrants, to determine if such instruments are derivatives or contain features that qualify
as embedded derivatives. For derivative financial instruments that are accounted for as liabilities, the derivative instrument is
initially recorded at its fair value and is then re-valued at each reporting date, with changes in the fair value reported
in the Statement of Operations.  Depending on the features of the derivative financial instrument, the Company uses either the
Black-Scholes option-pricing model or a binomial model to value the derivative instruments at inception and subsequent valuation
dates.  The classification of derivative instruments, including whether such instruments should be recorded as liabilities
or as equity, is re-assessed at the end of each reporting period.
F-
8
Stock Based Compensation
Effective December 1, 2018, the Company
adopted ASU 2018-07, by which the accounting for share-based payments to non-employees and employees is substantially aligned.
Non-employee share-based payment awards are measured at grant-date fair value of the equity instruments that the Company is obligated
to issue when the good has been delivered or the service has been rendered and any other conditions necessary to earn the right
to benefit from the instruments have been satisfied. There was no cumulative effect of the adoption of this standard.
Share-based compensation cost is recorded
for all option grants and awards of non-vested stock based on the grant date fair value of the award, and is recognized over the
service period required for the award. Prior to December 1, 2018, share-based compensation cost for non-employees was remeasured
over the vesting term as earned.
Stock-based compensation expense
is recognized in the consolidated financial statements based on the fair value of the awards granted. Stock-based compensation cost
is measured at the grant date based on the fair value of the award and is recognized as expense over the requisite service
period, which generally represents the vesting period. The Company calculates the fair value of stock options using the
Black-Scholes option-pricing model at grant date.
General and administrative expenses
The significant components of general and
administrative expenses consist of bank fees, printing, filing fees, other office expenses, and business license
and permit fees.
Research and development
The Company expenses the cost of research
and development as incurred.  Research and development expenses include costs incurred in funding research and development
activities, license fees, and other external costs. Nonrefundable advance payments for goods and services that will be used in
future research and development activities are expensed when the activity is performed or when the goods have been received, rather
than when payment is made.
Income Taxes
Deferred tax assets and liabilities are
computed based upon the difference between the financial statement and income tax basis of assets and liabilities using the enacted
marginal tax rate applicable when the related asset or liability is expected to be realized or settled.  Deferred income tax
expenses or benefits are based on the changes in the asset or liability each period.  If available evidence suggests that
it is more likely than not that some portion or all of the deferred tax assets will not be realized, a valuation allowance is required
to reduce the deferred tax assets to the amount that is more likely than not to be realized. Future changes in such valuation
allowance are included in the provision for deferred income taxes in the period of change.
Deferred income taxes may arise from temporary
differences resulting from income and expense items reported for financial accounting and tax purposes in different periods. Deferred
taxes are classified as current or non-current, depending on the classification of assets and liabilities to which they relate.
Deferred taxes arising from temporary differences that are not related to an asset or liability are classified as current or non-current
depending on the periods in which the temporary differences are expected to reverse.
The
Company applies a more-likely-than-not recognition threshold for all tax uncertainties, which only allows the recognition of those
tax benefits that have a greater than fifty percent likelihood of being sustained upon examination by the taxing authorities. As
of November 30,
2019, the Company reviewed its tax positions and determined there were no outstanding, or retroactive tax
positions with less than a 50% likelihood of being sustained upon examination by the taxing authorities, therefore this standard
has not had a material effect on the Company.
The
Company's policy for recording interest and penalties associated with audits is to record such expense as a component of
income tax expense. There were no amounts accrued for penalties or interest during the years ended November 30,
2019. Management
is currently unaware of any issues under review that could result in significant payments, accruals or material deviations from
its position.
Recent accounting pronouncements
On February 2016, the FASB issued ASU No. 2016-02,
Leases (Topic
842)
. Under the new guidance, lessees will be required to recognize all leases (with the exception of short-term leases) on
the balance sheet as a lease liability, which is a lessee's obligation to make lease payments arising from a lease, measured
on a discounted basis and a right-of-use asset, which is an asset that represents the lessee¹s right to use, or control the
use of, a specified asset for the lease term.  The guidance in ASU 2017-11 is effective for the Company on December 1, 2019.  Early
adoption is permitted, and the guidance is to be applied using a full or modified retrospective approach. The Company does not
expect the adoption of the new standard to have a material impact on its Consolidated Financial Statements.
F-
9
In July 2017, the FASB issued ASU 2017-11,
Earnings
Per Share (Topic 260); Distinguishing Liabilities from Equity (Topic 480); Derivatives and Hedging (Topic 815): (Part I) Accounting
for Certain Financial Instruments with Down Round Features, (Part II) Replacement of the Indefinite Deferral for Mandatorily Redeemable
Financial Instruments of Certain Nonpublic Entities and Certain Mandatorily Redeemable Noncontrolling Interests with a Scope Exception.
The ASU allows companies to exclude a down round feature when determining whether a financial instrument (or embedded conversion
feature) is considered indexed to the entity's own stock. As a result, financial instruments (or embedded conversion features)
with down round features may no longer be required to be accounted classified as liabilities. A company will recognize the value
of a down round feature only when it is triggered and the strike price has been adjusted downward. For equity-classified freestanding
financial instruments, such as warrants, an entity will treat the value of the effect of the down round, when triggered, as a dividend
and a reduction of income available to common shareholders in computing basic earnings per share. For convertible instruments with
embedded conversion features containing down round provisions, entities will recognize the value of the down round as a beneficial
conversion discount to be amortized to earnings. The guidance in ASU 2017-11 is effective for the Company on December 1, 2019.
Early adoption is permitted, and the guidance is to be applied using a full or modified retrospective approach. The Company does
not expect the adoption of the new standard to have a material impact on its consolidated financial statements.
In December 2019, the FASB issued ASU No.
2019-12, "Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes ("ASU 2019-12"), which is intended
to simplify various aspects related to accounting for income taxes. ASU 2019-12 removes certain exceptions to the general
principles in Topic 740 and also clarifies and amends existing guidance to improve consistent application. This guidance is effective
for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2020, with early adoption permitted.
The Company is currently evaluating the impact of this standard on its consolidated financial statements and related disclosures.
Recent adopted pronouncements
In May 2014, the FASB issued ASU 2014-09,
Revenue from Contracts with Customers (Topic 606), as modified by ASU 2015-14, Revenue from Contracts with Customers (Topic
606): Deferral of the Effective Date
, ASU 2016-08,
Revenue from Contracts with Customers (Topic 606): Principal versus
Agent Considerations (Reporting Revenue Gross versus Net),
ASU 2016-10,
Revenue from Contracts with Customers (Topic 606):
Identifying Performance Obligations and Licensing
, and ASU 2016-12,
Revenue from Contracts with Customers (Topic 606):
Narrow-Scope Improvements and Practical Expedients
. The revenue recognition principle in ASU 2014-09 is that an entity should
recognize revenue to depict the transfer of goods or services to customers in an amount that reflects the consideration to which
the entity expects to be entitled in exchange for those goods or services. In addition, new and enhanced disclosures will be required.
Companies may adopt the new standard either using the full retrospective approach, a modified retrospective approach with practical
expedients, or a cumulative effect upon adoption approach. The adoption of this standard on December 1, 2018 did not impact
the Company's consolidated financial statements.
In
August 2016, the FASB issued ASU No. 2016-15,
Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and
Cash Payments
. This new standard clarifies certain aspects of the statement of cash flows, including the classification of
debt prepayment or debt extinguishment costs or other debt instruments with coupon interest rates that are insignificant in relation
to the effective interest rate of the borrowing, contingent consideration payments made after a business combination, proceeds
from the settlement of insurance claims, proceeds from the settlement of corporate-owned life insurance policies, distributions
received from equity method investees and beneficial interests in securitization transactions. This new standard also clarifies
that an entity should determine each separately identifiable source of use within the cash receipts and payments on the basis of
the nature of the underlying cash flows. In situations in which cash receipts and payments have aspects of more than one class
of cash flows and cannot be separated by source or use, the appropriate classification should depend on the activity that is likely
to be the predominant source or use of cash flows for the item.
The adoption of this standard on December 1, 2018 did not
impact the Company's consolidated financial statements.
In
June 2018, the FASB issued ASU 2018-07,
Compensation – Stock Compensation (Topic 718), Improvements to Nonemployee Share-Based
Payment Accounting
. This ASU is intended to simplify aspects of share-based compensation issued to non-employees by making
the guidance consistent with the accounting for employee share-based compensation. The
adoption of this standard on December
1, 2018 did not impact the Company's consolidated financial statements.
Note 4 – Loss per share
Basic net loss per share was calculated
by dividing net loss by the weighted-average common shares outstanding during the period.  Diluted net loss per share
was calculated by dividing net loss by the weighted-average common shares outstanding during the period using the treasury stock
method or the two-class method, whichever is more dilutive. The table below summarizes potentially dilutive securities that
were not considered in the computation of diluted net loss per share because they would be anti-dilutive.
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10
Potentially dilutive securities
November 30, 2019
November 30, 2018
Warrants
7,179,994
4,984,058
Convertible Notes
5,732,000
2,014,819
Stock Options
1,200,000
900,000
Note 5 – Asset Acquisition
On November 23, 2018, the Company entered
into an Asset Sale Agreement ("ASA") with GE Healthcare Limited ("GE") whereby the Company acquired GE's
radiopharmaceutical drug, Metastron® and all related intellectual property including, but not limited to sales and distribution
data, market authorizations and trademarks for Metastron® in various countries in exchange for an upfront payment of $500,000,
a one-time milestone payment based on future sales, and royalty payments based on future sales. The Company did not acquire any
workforce, manufacturing, inventory, sales agreements, or distribution agreements associated with Metastron®. The first commercial
sale of Metastron™ by the Company will occur only after the successful transfer or assignment of all intellectual property,
material sales and distribution data, technical transfer and the establishment of new manufacturing sites by the Company and under
the appropriate regulatory filings required by the jurisdictions in which Metastron™ is sold.
The
acquired assets are concentrated in a single asset and the set is not considered a business. As such, the transaction is recognized
as the acquisition of a finite-lived intangible asset. The one-time milestone payment based on future sales, and royalty payments
based on future sales will be recognized when the payments are probable and estimable, which is expected to be when the related
sales targets are achieved and the payments payable to GE. The acquired asset is being amortized on a straight-line basis over
its estimated 10 year
life. Amortization expense for the year ended November 30, 2019 was $50,000. Amortization expense
for the year ended November 30, 2018 was not significant. The estimated remaining amortization expense for each of the five succeeding
fiscal year:
Year ended November 30,
2020
$
50,000
2021
50,000
2022
50,000
2023
50,000
2024
50,000
Thereafter
200,000
$
450,000
Note 6 – Convertible Notes
November 30, 2019
November 30, 2018
Convertible Notes Payable, current:
Principal value of 2018 Debentures
$
2,730,000
$
-
Fair value of bifurcated contingent put option
74,299
-
Debt discount
(61,173
)
-
Carrying value of 2018 Debentures
2,743,126
-
Principal value of 2019 August Debenture
550,000
-
Debt discount
(49,834
)
-
Carrying value of 2019 August Debenture
500,166
-
Total carrying value of convertible notes payable, current
$
3,243,292
$
-
Convertible Notes Payable, long-term:
Principal value of 2018 Debentures
$
-
$
4,000,000
Fair value of bifurcated contingent put option
-
262,000
Debt discount
-
(1,388,728
)
Carrying value of 2018 Debentures
-
2,873,272
Principal value of 2019 October Debenture
500,000
4,000,000
Fair value of bifurcated contingent put option
29,382
262,000
Debt discount
(82,047
)
(1,388,728
)
Carrying value of 2019 October Debenture
447,335
2,873,272
Total carrying value of convertible notes, long-term
$
447,335
$
2,873,272
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11
2019 August Debenture
On August 28, 2019, the Company entered
into a securities purchase agreement with an accredited investor pursuant to which the Company sold a convertible debenture (the
 "August Debenture") with a maturity date of twelve months after the issuance thereof for $500,000. The August Debenture
is in the aggregate principal amount of $550,000, which amount includes an original issue discount of $40,000, and payment of the
lenders legal fees of $10,000. The August Debenture carries an interest rate of 10% per annum upon an event of default, as defined,
the outstanding balance of the August Debenture bears interest at a rate of 18% per annum. The Company may prepay the August Debenture
at 110% of the outstanding aggregate principal amount within the first six months of issuance and at 125% of the outstanding aggregate
principal amount thereafter. Since the Company can elect to settle the August Debenture in either cash or in shares, the Company
will recognize any payment in addition to the principal amount as part of debt extinguishment upon the occurrence of the payment
event.
In certain circumstances, a premium is
due upon the outstanding balance upon written notice from the lender. A premium of fifteen percent is due for each occurrence of
any major default, a premium of ten percent is due for each occurrence of an unapproved variable security issuance default, and
a premium of five percent is due for each occurrence of any minor default.
The lender has the right to convert the
outstanding aggregate principal amount at any time at the conversion price of $2.50 per share. At any time that is six months after
the issuance, the lender may redeem a portion of the August Debenture, not to exceed $150,000 in any month. The Company may pay
such a redemption in cash and/or shares of its common stock. Any payment of such a redemption in shares of common stock shall be
made at the lesser of $2.50 or 93% of the average of the four lowest VWAPs in the prior ten trading day, provided that no such
conversion price shall be less than $2.00. Any payment of such a redemption in cash shall be at 120% of the amount being redeemed.
Moreover, the Company has the right to defer up to two (2) separate redemptions for up to thirty (30) days each by providing written
notice to the lender within three (3) trading days of its receipt of a redemption notice. In the event the Company elects to exercise
its deferral right, the August Debenture's outstanding balance shall automatically be increased by ten percent (10%) of the
redemption amount to which such deferral relates.
2019 October Debenture
On October 11, 2019, the Company
entered into another securities purchase agreement with an accredited investor to place Convertible Debentures (the "October
Debenture") with a maturity date of eighteen months after the issuance thereof in the aggregate principal amount of up to
$750,000 provided that in case of an event of default, the October Debenture may become at the holder's election immediately
due and payable. The initial closing occurred on October 11, 2019, when the Company issued a Debenture is in the aggregate principal
amount of $500,000 for proceeds of $485,000.
The October Debenture may be converted
at any time on or prior to maturity at the lower of $1.00 or 93% of the average of the four lowest daily VWAPs during the 10 consecutive
trading days immediately preceding the conversion date, provided that as long as the Company is not in default under the October
Debenture, the conversion price may never be less than $0.50. The Company may not convert any portion of a October Debenture if
such conversion would result in the holder beneficially owning more than 4.99% of our then issued and common stock, provided that
such limitation may be waived by the holder with 65 days' notice.
Any time after the six-month anniversary
of the issuance of the October Debenture that the daily VWAP is less than $0.50 for a period of twenty consecutive trading days
(the "Triggering Date") and only for so long as such conditions exist after a Triggering Date, the Company shall make
monthly payments beginning on the last calendar day of the month when the Triggering Date occurred. Each monthly payment shall
be in an amount equal to the sum of (i) the principal amount outstanding as of the Triggering Date divided by the number of such
monthly payments until maturity, (ii) a redemption premium of 20% in respect of such principal amount and (iii) accrued and unpaid
interest hereunder as of each payment date. The Company may, no more than twice, obtain a thirty-day deferral of a monthly payment
due as a result of a Triggering Date through the payment of a deferral fee in the amount equal to 10% of the total amount of such
monthly payment. Each deferral payment may be paid by the issuance of such number of shares as is equal to the applicable deferral
payment divided by a price per share equal to 93% of the average of the four lowest daily VWAPs during the 10 consecutive Trading
Days immediately preceding the due date in respect of such monthly payment being deferred, provided that such shares issued will
be immediately freely tradable shares in the hands of the holder.
Upon issuance of the October Debenture,
the Company recognized a debt discount of approximately $89,000, resulting from the recognition of issuance costs of $15,000 and
a bifurcated embedded derivative of $74,000.   The monthly payment provision within the October Debenture is a contingent
put option that is required to be separately measured at fair value, with subsequent changes in fair value recognized in the Consolidated
Statement of Operations. The fair value estimate is a Level 3 measurement. The Company estimated the fair value of the monthly
payment provision by estimating the probability of the occurrence of a Triggering Date and applying the probability to the
discounted maximum redemption premium for any given payment with the following key inputs:
November 30, 2019
October 11, 2019
Strike price
$
1.00
$
1.00
Terms (years)
1.4
1.5
Volatility
99.5
%
93.4
%
Risk-free rate
1.6
%
1.7
%
Dividend yield
0
%
0
%
2018 Debentures
On September 21, 2018, the Company entered
into a securities purchase agreement with an accredited investor to place Convertible Debentures (the "2018 Debentures")
with a maturity date of eighteen months after the issuance thereof in the aggregate principal amount of up to $4,000,000 (the "Transaction"),
provided that in case of an event of default, the 2018 Debentures may become at the holder's election immediately due and
payable. The initial closing of the Transaction occurred on September 21, 2018 when the Company issued a Debenture for $2,000,000.
The second closing occurred on November 1, 2018, when the Company issued another Debenture for $2,000,000. The 2018 Debentures
bear interest at the rate of 5.5% per annum. In addition, the Company paid to the holder an up-front fee equal to 2.5% of the amount
of the 2018 Debentures.
F-
12
The 2018 Debentures may be converted at
any time on or prior to maturity at the lower of $4.00 or 93% of the average of the four lowest daily VWAPs during the 10 consecutive
trading days immediately preceding the conversion date, provided that as long as the Company are not in default under the 2018
Debentures, the conversion price may never be less than $2.00.
Any time after the six-month anniversary
of the issuance of a Debenture that the daily VWAP is less than $2.00 for a period of twenty consecutive trading days (the "Triggering
Date") and only for so long as such conditions exist after a Triggering Date as that term is defined in the Transaction documents,
the Company shall make monthly payments beginning on the last calendar day of the month when the Triggering Date occurred. Each
monthly payment shall be in an amount equal to the sum of (i) the principal amount outstanding as of the Triggering Date divided
by the number of such monthly payments until maturity, (ii) a redemption premium of 20% in respect of such principal amount and
(iii) accrued and unpaid interest hereunder as of each payment date. The Company may, no more than twice, obtain a thirty-day deferral
of a monthly payment due as a result of a Triggering Date through the payment of a deferral fee in the amount equal to 10% of the
total amount of such monthly payment. Each deferral payment may be paid by the issuance of such number of shares as is equal to
the applicable deferral payment divided by a price per share equal to 93% of the average of the four lowest daily VWAPs during
the 10 consecutive Trading Days immediately preceding the due date in respect of such monthly payment being deferred, provided
that such shares issued will be immediately freely tradable shares in the hands of the holder.
Upon issuance of the 2018 Debentures, the
Company recognized a debt discount of approximately $1.5 million, resulting from the recognition of a beneficial conversion feature
of $1.0 million, issuance costs of $358,000 and a bifurcated embedded derivative of $173,000.  The beneficial conversion feature
was recognized as the intrinsic value of the embedded derivatives on issuance of the 2018 Debentures.  The monthly
payment provision within the 2018 Debentures is a contingent put option that is required to be separately measured at fair value,
with subsequent changes in fair value recognized in the Consolidated Statement of Operations. The fair value estimate is a Level
3 measurement. The Company estimated the fair value of the monthly payment provision by estimating the probability of the occurrence
of a Triggering Date and applying the probability to the discounted maximum redemption premium for any given payment with the following
key inputs:
November 30, 2019
November 30, 2018
Strike price
$
1.00
$1.95 - $2.97
Terms (years)
0.8
1.2 - 1.4
Volatility
99.5
%
72.1% - 76.5%
Risk-free rate
1.6
%
2.4% - 2.5%
Dividend yield
0
%
0%
Debt Conversion
The following table summarizes debt conversion
during the year ended November 30, 2019:
Principal value of 2018 Debentures
$
1,270,000
Accrued interest
136,120
Fair value of bifurcated contingent put option
112,900
Debt discount
(25,509
)
Sub-total
$
1,493,511
Fair value of common stock issued (2,320,099 shares)
$
2,220,571
Loss on conversion of debt
$
595,795
Interest expense recognized from conversion of debt
$
131,265
Debt Extinguishment
On September 23, 2019, the Company amended
the conversion price of the 2018 Debentures (the "Amendment"). The conversion price of the 2018 Debentures was reduced
to the lower of (i) $1.00, (ii) 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately
preceding the conversion date, provided that as long as the Company is not in default under the Debentures, the conversion price
may never be less than $0.50. Additionally, the maturity date of the 2018 Debentures was extended to September 21, 2020.
F-
13
The Amendment was treated as an extinguishment
for accounting purposes. The following table summarizes the Amendment on September 23, 2019, which resulted in a $gain from debt
extinguishment of approximately $5,000. The gain is presented net in the Consolidated Statements of Operations with loss on the
conversion of debt.
Principal value of 2018 Debentures
$
3,565,000
Fair value of bifurcated contingent put option
697,000
Debt discount
(418,115
)
Carrying value of 2018 Debentures on September 23, 2019
3,843,885
Principal value of modified 2018 Debentures
3,565,000
Fair value of bifurcated contingent put option
369,401
Debt discount
(95,164
)
Fair value of amended 2018 Debentures on September 23, 2019
3,839,237
Gain from debt extinguishment
$
4,648
Interest expense
Interest expense, included in the accompanying
Consolidated Statements of Operations, is comprised of the following for each period presented:
For the year ended November 30,
2019
2018
Interest expense based on the coupon interest rate of the outstanding debt
$
327,966
$
29,756
Accretion of debt discount
1,001,153
132,348
Interest expense related to deferral fee
131,265
-
Total interest expense
$
1,460,384
$
162,104
Note 7 – Commitments and Contingencies
Legal
Periodically,
the Company reviews
the status of significant matters, if any exist, and assesses its potential financial exposure. If the
potential loss from any claim or legal claim is considered probable and the amount can be estimated, the Company accrues a liability
for the estimated loss.  Legal proceedings are subject to uncertainties, and the outcomes are difficult to predict. 
Because of such uncertainties, accruals are based on the best information available at the time.  As additional information
becomes available, the Company reassesses the potential liability related to pending claims and litigation.
BNI matter
On
December 28, 2018, the Company commenced litigation against BioNucleonics, Inc. ("BNI") and parties related to BNI
in the Supreme Court of New York, New York County
(removed to federal court in February 2019). The litigation stems from
a license agreement that the Company entered into with BNI in 2016 and amended from time to time. Under the agreement with BNI,
the Company were granted a worldwide, exclusive license on certain BNI intellectual property and the option to acquire the BNI
IP within three years of the agreement. The BNI IP consists of generic Strontium Chloride SR89 (generic Metastron®) ("SR89")
and all of BNI's intellectual property relating to it ("BNI IP"). SR89 is a radiopharmaceutical therapeutic for
cancer bone pain therapy.
F-
14
The
Company believes that it has fulfilled the obligations under
the agreement to exercise an option to acquire the BNI IP and
has notified BNI of such exercise, but BNI has not transferred the BNI IP to the Company. As a result, the Company has commenced
litigation to, among other actions, obtain all of the BNI IP. The Company also seeks judgments against BNI and related parties
for the misappropriation of funds, breach of contract, fraud and fraudulent inducement. In February 2019, such lawsuit was removed
to the Federal court located in the Southern District of New York. On September 23, 2019, the Company entered into a settlement
agreement with BNI and parties related to BNI. Pursuant to the terms of the settlement agreement, the Company settled its dispute
with BNI and all parties to the litigation dismissed their claims in exchange for entering into a Second Amendment to the License
Agreement (entered into on September 23, 2019) pursuant to which:
•
BNI agreed to immediately transfer and/or assign to the Company all intellectual property, patents and products that is owned by BNI that is related to Strontium-Chloride 89;
•
The Company agreed to issue BNI 50,000 shares of its common stock upon the entry into the settlement agreement and 100,000 shares of its common stock upon the approval of the U.S. Food and Drug Administration ("FDA") approval of BNI's Prior Approval Supplements filing
•
The Company agreed to make a cash payment to BNI of $25,000
•
The Company agreed to an on-going royalty payment of 3% on all gross profits derived by the Company from the sale of Strontium-Chloride 89 and MetastronTM; and
•
The Company agreed to assume fees and expenses related to (i) all outstanding CMO fees owed by BNI to IsoTherapeutics relating to Strontium-Chloride 89 (approximately $67,000), (ii) all outstanding fees owed by BNI to the FDA relating to Strontium-Chloride 89 (approximately $208,000) and (iii) related fees for the development and approval of Strontium-Chloride 89 following the date of the settlement agreement.
Advisory Agreements
The Company entered into customary consulting
arrangements with various counterparties to provide consulting services, business development and investor relations services,
pursuant to which the Company agreed to issue shares of common stock as services are received.
Lease Agreement
In
December 2016, the Subsidiary entered into a lease agreement for its office space located in Cayman Islands for $30,000 per annum. 
The initial term of the agreement
ended in December 2019 and the Company has renewed its office lease agreement for another
three years with the same terms.
Rent expense is classified within general
and administrative expenses on a straight-line basis and included in the accompanying Consolidated Statements of Operations as
follows:
For the year ended November 30,
2019
2018
Rent expense
$
30,000
$
30,000
License Agreements
Mannin
On October 29, 2015, the Company entered
into a Patent and Technology License and Purchase Option Agreement ("Exclusive License") with a vendor whereby the
Company was granted a worldwide, exclusive, license on, and option to, acquire certain intellectual property ("Mannin IP")
which initially focused on developing a first-in-class eye drop treatment for glaucoma within the four-year term of the Exclusive
License.
On March 26, 2019, the Company entered
into an amendment to the Patent and Technology License and Purchase Option Agreement that it initially entered into with Mannin
Research Inc. on October 29, 2015 (the "Mannin Agreement"). Under such amendment, the term of the option granted under
the Mannin Agreement was extended to October 29, 2021 in exchange for the Company issuing 100,000 shares to Mannin Research Inc.
on April 9, 2019.
During
the years ended November 30,
2019 and 2018, the Company incurred approximately $2.1 million and $2.1 million, respectively,
in research and development expenses to fund the costs of development of the eye drop treatment for glaucoma pursuant to the Exclusive
License.
Washington University
On March 9, 2019, the Company entered into
an Exclusive License Agreement with Washington University for license of a diagnostic marker for determining the severity of glaucoma
using the expression levels of Growth Differentiation Factor 15. The agreement calls for the Company to pay an initial fee of approximately
$88,000, pay annual maintenance fees ranging from $15,000 to $75,000, make additional payments upon the following milestones:
•
The first commercial sale of a companion diagnostic product;
F-
15
•
Initiation of a clinical trial for a diagnostic product to support FDA PMA or 510(k) regulatory approval or the foreign equivalent;
•
PMA or 510(k) regulatory approval by the FDA or the foreign equivalent; and
•
The first commercial sale of a diagnostic product.
In additional to the above payments, royalty
payments based upon sales of a companion diagnostic product or diagnostic product are required.
Note 8 - Related Party Transactions
The Company entered into consulting agreements
with certain management personnel and stockholders for consulting and legal services.  Consulting and legal expenses
resulting from such agreements were included within general and administrative expenses in the accompanying Consolidated Statements
of Operations as follows:
For the year ended November 30,
2019
2018
Consulting and legal expenses
$
531,751
$
295,000
Note 9 - Stockholders' Equity
(Deficit)
As
of November 30,
2019, and 2018, the Company is authorized to issue up to 250,000,000 shares of its $0.001 par value common
stock and up to 100,000,000 shares of its $0.001 par value preferred stock.
2019 activity
Issuance of units in private placement
offerings
In September 2019, the Company executed
securities purchase agreements with various investors to purchase 335,887 units, each unit consisting of (i) one share of common
stock and (ii) one and one half (1.5) warrants to purchase a share of common stock, at $0.86, which is 110% of the closing price
of the Company's common stock as listed on OTCQB on September 18, 2019, raising approximately $208,000 in cash.
In October and November 2019, the Company
entered into a series of securities purchase agreements for the sale of 1,185,715 units at a $0.35 per unit sales price. The Company
raised approximately $415,000 in cash. Each unit consisted of one share and one warrant to purchase a share of common stock at
an exercise price of $0.50.
Issuance
of shares and units
for services
During the year ended November 30, 2019,
the Company issued an aggregate of 1,428,870 shares of the Company common stock to various vendors for advisory services, valued
at approximately $1.5 million based on the estimated fair market value of the stock on the date of grant and was recognized within
general and administrative expenses in the accompanying Consolidated Statements of Operations.
During the year ended November 30, 2019,
the Company issued 148,261 units (with each unit consisting of one share of common stock and 1.5 warrants to purchase a share of
common stock) to the Company's legal counsel in exchange for $92,000 of services provided. The fair value of the units on
the issuance date was approximately $168,000. The Company recorded $76,000 as settlement cost, which is the value in excess of
the services provided. The Company's Chief Legal Officer and a Director is the Managing Partner at the law firm where these
services were provided.
Issuance of shares for debt
conversion
During the year ended November 30,
2019, the Company issued approximately 2.3 million shares of common stock to convert approximately $1.5 million outstanding
debt, including approximately $136,000 accrued interest (see Note 6).
F-
16
2018 activity
Issued for services
The Company entered into customary consulting
arrangements with various counterparties to provide consulting services, business development and investor relations services.  During
the year ended November 30, 2018, the Company issued an aggregate of 296,952 shares of the Company common stock to various vendors
for investor relation and introductory services, valued at approximately $800,000 based on the estimated fair market value of the
stock on the date of grant and was recognized within general and administrative expenses in the accompanying consolidated statements
of operations for the year ended November 30, 2018.
In June 2018, the Company issued warrants
to purchase up to 84,000 shares of the Company's common stock to one vendor for services. The warrants are exercisable for
three years at a per share price of $3.61.
In September 2018, the Company issued warrants
to purchase up to 100,000 shares of the Company's common stock to one vendor for services. The warrants are exercisable for
five years at a per share price of $2.15.
Registered public financing
On February 1, 2018, the Company sold an
aggregate of 1,711,875 shares of common stock, and 1,711,875 warrants to purchase shares of common stock, in a registered public
offering for gross proceeds of approximately $5,478,000.  The warrants are exercisable for five years at $3.20 per share.
  The Company paid placement agent commissions of approximately $438,000 and issued the placement agent five-year warrants
to purchase 81,688 shares of common stock at $3.84 per share. After the placement agents' commissions and other offering
expenses, the Company netted approximately $4,945,000 of proceeds.
Note 10 - Warrants and Options
Summary of warrants
The
following represents a summary of all outstanding warrants to purchase the Company's common stock, including warrants issued
to vendors for services and warrants issued as part of the units sold in the private placements, at November 30,
2019 and
2018 and the changes during the period then ended:
Weighted Average
Weighted Average
Remaining Contractual
Warrants
Exercise Price
Life (years)
Intrinsic Value
Outstanding at December 1, 2017
3,083,995
$
3.67
4.0
$
250,000
Issued
1,977,563
3.19
4.1
-
Forfeited/expired
(77,500
)
3.96
-
-
Outstanding at November 30, 2018
4,984,058
$
3.48
3.5
$
250,000
Issued
3,655,936
0.93
3.7
-
Forfeited/expired
(1,460,000
)
3.28
-
-
Outstanding at November 30, 2019
7,179,994
$
2.22
3.2
$
2,463,340
Exercisable at November 30, 2019
7,129,994
$
2.22
3.2
$
2,463,340
Fair value of all outstanding warrants issued for services
was calculated with the following key inputs:
For the year ended November 30,
2019
2018
Strike price
$0.39 - $2.02
$2.02
- $3.40
Term (years)
1.3 - 5.0
3.0 - 5.0
Volatility
79%
- 130%
123%
- 130%
Risk-free rate
1.5% - 2.8%
2.5% - 2.8%
Dividend yield
0.0%
0.0%
F-
17
Options issued for services
The
following represents a summary of all outstanding options to purchase the Company's common stock at November 30,
2019
and 2018 and the changes during the period then ended:
Weighted Average
Weighted Average
Remaining Contractual
Options
Exercise Price
Life (years)
Intrinsic Value
Outstanding at December 1, 2017
450,000
$
4.00
4.5
$
220,500
Issued
450,000
3.37
4.5
-
Outstanding at November 30, 2018
900,000
$
3.68
4.0
$
-
Issued
1,450,000
1.31
2.7
-
Forfeited/expired
(1,150,000
)
3.13
-
-
Outstanding at November 30, 2019
1,200,000
$
1.35
3.4
$
402,500
Exercisable at November 30, 2019
1,125,000
$
1.35
3.3
$
376,250
Fair value of all outstanding options was
calculated with the following key inputs:
For the year ended November 30,
2019
2018
Exercise price
$0.43 - $1.61
$3.00 - $3.61
Expected term (years)
2.7 - 5.0
5.0
Volatility
87% - 98%
128% - 130%
Risk-free rate
1.5% - 2.0%
2.5% - 2.7%
Dividend yield
0.00%
0.00%
Repricing of Existing Warrants and Options
On
September 24, 2019, the Company modified an aggregated of 2,610,000 stock options and warrants (the "Options and Warrants")
that were originally granted to
Mr. Denis Corin, the Company's Chief Executive Officer and Chairman, Mr. William Rosenstadt,
the Company's Chief Legal Officer and a Director, and two other consultants for services provided to the Company. The exercise
price of the Options and Warrants were reduced to $1.25 per share.
The Company immediately recognized $141,550
incremental stock-based compensation on October 1, 2019, and the remaining $6,000, to be fully recognized on February 29, 2020.
Stock-based Compensation
Stock-based
compensation expense is classified within
general and administrative expenses as a result of the shares, outstanding warrants
and options issued to consultants and employees and included in the accompanying Consolidated Statements of Operations as follows:
For the year ended November 30,
2019
2018
Stock-based compensation expense
$
2,496,296
$
2,650,477
As
of November 30,
2019, the estimated unrecognized stock-based compensation associated with these agreements is approximately
$31,000 and will be fully recognized by February 29, 2020.
Note 11 - Income Taxes
At
November 30, 2019, the Company has a net operating loss ("NOL") carryforward for Federal and state income tax purposes
totaling approximately $24 million available to reduce future taxable income.
Of this amount, approximately $14.1 million
of Federal net operating losses are carried over indefinitely, while the remaining amount begins to expire in 2034. Some of the
state net operating losses follow the Federal Tax Cuts and Jobs Act and are carried over indefinitely, and others have various
expiration dates.
The NOL carry forward is subject to review
and possible adjustment by the Internal Revenue Service and state tax authorities. Under the Internal Revenue Code ("IRC")
Sections 382 and 383, annual use of the Company's net operating loss carryforwards to offset taxable income may be limited
based on cumulative changes in ownership. The Company has not completed an analysis to determine whether any such limitations have
been triggered as of November 30, 2019. The amount of the annual limitation, if any, will be determined based on the value of the
Company immediately prior to the ownership change. Subsequent ownership changes may further affect the limitation in future years.
F-
18
The Company has evaluated the positive
and negative evidence bearing upon the realizability of its deferred tax assets. Based on the Company's history of operating
losses since inception, the Company has concluded that it is more likely than not that the benefit of its deferred tax assets will
not be realized. Accordingly, the Company has provided a full valuation allowance for deferred tax assets as of November 30, 2019
and 2018. The valuation allowance increased by approximately $3.0 million and $1.2 million for the fiscal years ended November
30, 2019 and 2018.
The tax effects of the temporary differences
and carry forwards that give rise to deferred tax assets consist of the following:
As of November 30,
2019
2018
Deferred tax assets:
Net-operating loss carryforward
$
8,322,959
$
5,666,313
Stock-based compensation
4,417,762
4,014,863
License agreement
476,906
463,269
Tax amortization for license agreement
(613,954
)
(221,988
)
Charitable contributions
303
294
Other accrued expenses
399,411
76,411
Total deferred tax assets
13,003,387
9,999,162
Valuation allowance
(13,003,387
)
(9,999,162
)
Deferred tax asset, net of allowance
$
-
$
-
A reconciliation of the statutory income tax rates and the Company's
effective tax rate is as follows:
For the year ended November 30,
2019
2018
Statutory Federal income tax rate
(21.0
)%
(22.1
)%
State and local taxes, net of Federal tax benefit
(13.6
)%
(11.6
)%
Deferred tax true-up
0.4
%
(4.4
)%
Gain/loss on conversion and extinguishment of debt
2.0
%
0.0
%
Loss on settlement
0.3
%
0.0
%
Change in fair value of embedded conversion option and related accretion of interest expense
4.2
%
0.8
%
Meals and entertainment
0.1
%
0.0
%
Non-U.S. operations
1.4
%
1.3
%
Deferred tax rate change
(
3.0
)
%
22.7
%
Change in Valuation Allowance
29.2
%
13.3
%
Income Taxes Provision (Benefit)
0.0
%
0.0
%
F-
19
The Company's major tax jurisdictions are the United States
and New York. All of the Company's tax years will remain open starting 2014 for examination by the Federal and state tax authorities
from the date of utilization of the net operating loss. The Company does not have any tax audits pending.
Note 12 - Subsequent Events
On December 6,
2019, the Company issued a debenture for $1,000,000 pursuant to a securities purchase agreement with an accredited investor. The
debenture has a maturity date of June 6, 2021. The debenture bears interest at the rate of 5.5% per annum, and on issuance, the
Company paid to the holder a commitment fee equal to 2.5% of the amount of the debenture.
On
January 15, 2020, the Company issued another debenture for $1,000,000 pursuant to the same securities purchase agreement
dated December 6, 2019. The debenture has a maturity date of June 6, 2021, provided that in case of an event of default, the debenture
may become at the holder's election immediately due and payable. The debenture bears interest at the rate of 5.5% per annum,
and on issuance, the Company paid to the holder a commitment fee equal to 2.5% of the amount of the debenture.
On February 10, 2020, the Company issued
885,000 warrants to certain consultants and service providers in exchange for services rendered. The warrants are exercisable into
shares of the Company's common stock for five years from the date of issuance at an exercise price of $2.12 per share.
On February 10, 2020, the Company issued
1,500,000 warrants to the Company's two officers in exchange for services rendered. The warrants are exercisable into shares
of the Company's common stock in six months from their issuance until five years from the date of issuance at an exercise
price of $2.12 per share.
F-
20
Q BIOMED INC.
Condensed Consolidated Balance Sheets
(Unaudited)
As of February 29,
As of November 30,
2020
2019
ASSETS
Current assets:
Cash
$
740,644
$
172,636
Prepaid expenses and other current assets
57,162
17,662
Total current assets
797,806
190,298
Intangible assets, net
437,500
450,000
Total Assets
$
1,235,306
$
640,298
LIABILITIES AND STOCKHOLDERS' DEFICIT
Current liabilities:
Accounts payable
$
436,405
$
652,051
Accrued expenses
1,206,881
1,145,660
Accrued expenses - related party
4,000
7,500
Accrued interest payable
211,081
189,801
Convertible note payable, net
2,250,803
3,243,292
Total current liabilities
4,109,170
5,238,304
Long-term liabilities:
Convertible notes payable, net
2,356,726
447,335
Total long-term liabilities
2,356,726
447,335
Total Liabilities
6,465,896
5,685,639
Commitments and Contingencies (Note 6)
Stockholders' Deficit:
Preferred stock, $0.001 par value; 100,000,000 shares authorized; no shares issued and outstanding as of February 29, 2020 and November 30, 2019
—
—
Common stock, $0.001 par value; 250,000,000 shares authorized; 21,308,271 and 19,709,068 shares issued and outstanding as of February 29, 2020 and November 30, 2019, respectively
21,308
19,709
Additional paid-in capital
43,083,816
37,328,827
Accumulated deficit
(48,335,714
)
(42,393,877
)
Total Stockholders' Deficit
(5,230,590
)
(5,045,341
)
Total Liabilities and Stockholders' Deficit
$
1,235,306
$
640,298
The accompanying notes are an integral part of these
condensed consolidated financial statements
F-
21
Q BioMed Inc.
Condensed Consolidated Statements of Operations
(Unaudited)
For the Three Months ended
February
    29, 2020
February
    28, 2019
Operating expenses:
General and administrative expenses
$
5,569,971
$
1,242,711
Research and development expenses
262,872
814,699
Total operating expenses
5,832,843
2,057,410
Other (income) expenses:
Interest expense
197,516
290,672
Change in fair value of embedded derivatives
(88,522
)
27,000
Total other expenses
108,994
317,672
Net loss
$
(5,941,837
)
$
(2,375,082
)
Net loss per share - basic and diluted
$
(0.29
)
$
(0.16
)
Weighted average shares outstanding, basic and diluted
20,311,768
14,404,289
The accompanying notes are an integral part of these
condensed consolidated financial statements
F-
22
Q BIOMED INC.
Condensed Consolidated Statements of Changes in Shareholders' Equity (Deficit)
(Unaudited)
Common Stock
Additional Paid
Accumulated
Total
Stockholders'
Shares
Amount
in Capital
Deficit
Equity (Deficit)
Balance as of December 1, 2019
19,709,068
$
19,709
$
37,328,827
$
(42,393,877
)
$
(5,045,341
)
Issuance of common stock to convert notes payable
1,518,202
1,518
1,134,295
—
1,135,813
Cashless warrants exercise
20,860
21
(21
)
—
—
Share based compensation for services
60,141
60
4,515,227
—
4,515,287
Share based compensation related to warrants modification
—
—
105,488
—
105,488
Net loss
—
—
—
(5,941,837
)
(5,941,837
)
Balance as of February 29, 2020
21,308,271
$
21,308
$
43,083,816
$
(48,335,714
)
$
(5,230,590
)
Common Stock
Additional Paid
Accumulated
Total
Stockholders'
Shares
Amount
in Capital
Deficit
Equity (Deficit)
Balance as of December 1, 2018
14,290,236
$
14,290
$
31,994,129
$
(32,114,147
)
$
(105,728
)
Share based compensation for services
175,919
175
483,600
—
483,775
Net loss
—
—
—
(2,375,082
)
(2,375,082
)
Balance as of February 28, 2019
14,466,155
$
14,465
$
32,477,729
$
(34,489,229
)
$
(1,997,035
)
The accompanying notes are an integral part of these
condensed consolidated financial statements
F-
23
Q BIOMED INC.
Condensed Consolidated Statements of Cash Flows
(Unaudited)
For the three months
    ended
February 29, 2020
February 28, 2019
Cash flows from operating activities:
Net loss
$
(5,941,837
)
$
(2,375,082
)
Adjustments to reconcile net loss to net cash used in operating activities
Share based compensation for services
4,515,287
483,775
Share based compensation related to warrants modification
105,488
—
Change in fair value of embedded conversion option
(88,522
)
27,000
Accretion of debt discount
91,184
236,124
Amortization expense
12,500
12,500
Changes in operating assets and liabilities:
Prepaid expenses
(39,500
)
4,379
Accounts payable and accrued expenses
(157,925
)
185,983
Accrued interest payable
106,333
54,389
Net cash used in operating activities
(1,396,992
)
(1,370,932
)
Cash flows from financing activities:
Proceeds received from issuance of convertible note, net of discount of $35,000
1,965,000
—
Net cash provided by financing activities
1,965,000
—
Net increase (decrease) in cash
568,008
(1,370,932
)
Cash at beginning of period
172,636
2,694,413
Cash at end of the period
$
740,644
$
1,323,481
Supplemental disclosures:
Cash paid for interest
$
—
$
—
Cash paid for income taxes
$
—
$
—
Supplemental disclosures for noncash investing and financing activities:
Issuance of common stock to convert notes payable and accrued interest
$
1,135,814
$
—
Cashless warrants exercise
$
21
$
—
The accompanying notes are an integral part of these
condensed consolidated financial statements
F-
24
Q BIOMED INC.
Notes to Condensed Consolidated Financial Statements
Note 1 - Organization of the Company and Description
of the Business
Q BioMed Inc. ("Q BioMed") and its wholly
owned subsidiaries Q BioMed Cayman SEZC and QBMG Q BioMed Germany UG (collectively, "the Company"), is a
biomedical acceleration and development company focused on licensing, acquiring and providing strategic resources to life sciences
and healthcare companies. Q BioMed intends to mitigate risk by acquiring multiple assets over time and across a broad spectrum
of healthcare related products, companies and sectors.  The Company intends to develop these assets to provide returns
via organic growth, revenue production, out-licensing, sale or spinoff new public companies.
The accompanying condensed consolidated financial statements
include the accounts of the Company's wholly-owned subsidiary.  All intercompany balances and transactions have been
eliminated in consolidation.
Note 2 - Basis of Presentation
The accompanying interim period unaudited condensed
consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United
States of America ("U.S. GAAP") and applicable rules and regulations of the Securities and Exchange Commission ("SEC")
regarding interim financial reporting. These condensed consolidated financial statements are unaudited and should be read in conjunction
with the audited consolidated financial statements included in the Company's Annual Report on Form 10-K for the year ended
November 30, 2019. Certain disclosures included in the annual financial statements have been condensed or omitted from these financial
statements as they are not required for interim financial statements under U.S. GAAP and the rules of the SEC. These unaudited
consolidated financial statements reflect all adjustments that are, in the opinion of management, necessary for a fair statement
of the results for the interim periods presented. These adjustments are of a normal, recurring nature. Interim period operating
results may not be indicative of the operating results for a full year.
The Company currently operates in one business segment
focusing on licensing, acquiring and providing strategic resources to life sciences and healthcare companies. The Company is not
organized by market and is managed and operated as one business. A single management team reports to the chief operating decision
maker, the Chief Executive Officer, who comprehensively manages the entire business. The Company does not currently operate any
separate lines of business.
Going Concern
The accompanying condensed consolidated financial statements
are prepared assuming the Company will continue as a going concern, which contemplates the realization of assets and liquidation
of liabilities in the normal course of business.
The Company has and is expected to incur net losses
and cash outflows from operations in pursuit of extracting value from its acquired intellectual property. These matters, amongst
others, raise doubt about the Company's ability to continue as a going concern.
The Company has not generated any revenue from operations
since inception and has limited assets upon which to commence its business operations.  Management anticipates that the
Company will have to raise additional funds and/or generate revenue from drug sales within twelve months to continue operations.
Additional funding will be needed to implement the Company's business plan that includes various expenses such as fulfilling
our obligations under licensing agreements, legal, operational set-up, general and administrative, marketing, employee salaries
and other related start-up expenses. Obtaining additional funding will be subject to a number of factors, including general market
conditions, investor acceptance of our business plan and initial results from our business operations. These factors may impact
the timing, amount, terms or conditions of additional financing available to us. If the Company is unable to raise sufficient funds,
management will be forced to scale back the Company's operations or cease its operations.
Management has determined that there is substantial
doubt about the Company's ability to continue as a going concern within one year after the consolidated financial statements are
issued. The accompanying condensed consolidated financial statements do not include any adjustments relating to the recoverability
and classification of recorded asset amounts, or amounts and classification of liabilities that might result from this uncertainty.
Note 3 - Summary of Significant Accounting Policies
The Company's significant accounting policies
are disclosed in the audited financial statements for the year ended November 30, 2019 included in the Company's Form 10-K.
Since the date of such financial statements, there have been no changes to the Company's significant accounting policies.
F-
25
Q BIOMED INC.
Notes to Condensed Consolidated Financial Statements
Recent Accounting Standards
In December 2019, the FASB issued ASU No. 2019-12,
 "Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes ("ASU 2019-12"), which is intended to
simplify various aspects related to accounting for income taxes. ASU 2019-12 removes certain exceptions to the general
principles in Topic 740 and also clarifies and amends existing guidance to improve consistent application. This guidance is effective
for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2020, with early adoption permitted.
The Company is currently evaluating the impact of this standard on its consolidated financial statements and related disclosures.
Recent Adopted Standards
On February 2016, the FASB issued ASU No. 2016-02,
Leases (Topic
842)
. Under the new guidance, lessees will be required to recognize all leases (with the exception of short-term leases) on
the balance sheet as a lease liability, which is a lessee's obligation to make lease payments arising from a lease, measured
on a discounted basis and a right-of-use asset, which is an asset that represents the lessee¹s right to use, or control the
use of, a specified asset for the lease term.  The Company adopted ASC 842 on December 1, 2019, using the optional transition
method to apply the new guidance as of December 1, 2019, rather than as of the earliest period presented, and elected the package
of practical expedients described above. The adoption of this standard on December 1, 2019 did not impact the Company's condensed
consolidated financial statements as the Company is not subject to any lease agreements on December 1, 2019.
In July 2017, the FASB issued ASU 2017-11,
Earnings
Per Share (Topic 260); Distinguishing Liabilities from Equity (Topic 480); Derivatives and Hedging (Topic 815): (Part I) Accounting
for Certain Financial Instruments with Down Round Features, (Part II) Replacement of the Indefinite Deferral for Mandatorily Redeemable
Financial Instruments of Certain Nonpublic Entities and Certain Mandatorily Redeemable Noncontrolling Interests with a Scope Exception.
The ASU allows companies to exclude a down round feature when determining whether a financial instrument (or embedded conversion
feature) is considered indexed to the entity's own stock. As a result, financial instruments (or embedded conversion features)
with down round features may no longer be required to be accounted classified as liabilities. A company will recognize the value
of a down round feature only when it is triggered and the strike price has been adjusted downward. For equity-classified freestanding
financial instruments, such as warrants, an entity will treat the value of the effect of the down round, when triggered, as a dividend
and a reduction of income available to common shareholders in computing basic earnings per share. For convertible instruments with
embedded conversion features containing down round provisions, entities will recognize the value of the down round as a beneficial
conversion discount to be amortized to earnings. Early adoption is permitted, and the guidance is to be applied using a full or
modified retrospective approach. The adoption of this standard on December 1, 2019, did not impact the Company's condensed
consolidated financial statements.
Note 4 - Loss per share
Basic net loss per share was calculated by dividing
net loss by the weighted-average common shares outstanding during the period.  Diluted net loss per share was calculated
by dividing net loss by the weighted-average common shares outstanding during the period using the treasury stock method or the
two-class method, whichever is more dilutive. The table below summarizes potentially dilutive securities that were not considered
in the computation of diluted net loss per share because they would be anti-dilutive.
Potentially dilutive securities
February 29,
2020
November 30,
2019
Warrants
9,535,000
7,180,000
Convertible Notes
3,614,000
5,732,000
Stock Options
1,350,000
1,200,000
Note 5 - Convertible Notes
F-
26
Q BIOMED INC.
Notes to Condensed Consolidated Financial Statements
February 29, 2020
November 30, 2019
Convertible Notes Payable, current:
Principal value of 2018 Debenture
$
1,765,000
$
2,730,000
Fair value of bifurcated contingent put option
4,000
74,000
Debt discount
(33,000
)
(61,000
)
Carrying value of 2018 Debenture
1,736,000
2,743,000
Principal value of 2019 August Debenture
550,000
550,000
Debt discount
(35,000
)
(50,000
)
Carrying value of 2019 August Debenture
515,000
500,000
Total carrying value of convertible notes payable, current
$
2,251,000
$
3,243,000
Convertible Notes Payable, long-term:
Principal value of 2019 October Debenture
$
500,000
$
500,000
Fair value of bifurcated contingent put option
8,000
29,000
Debt discount
(69,000
)
(82,000
)
Carrying value of 2019 October Debenture
439,000
447,000
Principal value of 2019 December Debenture
1,000,000
—
Fair value of bifurcated contingent put option
107,000
—
Debt discount
(146,000
)
—
Carrying value of 2019 December Debenture
961,000
—
Principal value of 2020 January Debenture
1,000,000
—
Fair value of bifurcated contingent put option
107,000
—
Debt discount
(150,000
)
—
Carrying value of 2020 January Debenture
957,000
—
Total carrying value of convertible notes, long-term
$
2,357,000
$
447,000
During the quarter ended February
29, 2020, the Company raised approximately $2.0 million from issuance of various debentures (the "Debentures"). The
Debentures have a maturity date of June 6, 2021. The Debentures bear interest at the rate of 5.5% per annum, and on issuance, the
Company paid to the holder a commitment fee equal to 2.5% of the amount of the Debentures.
The Debentures may be converted at any time on
or prior to maturity at the lower of $3.00 or 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading
days immediately preceding the conversion date, provided that as long as we are not in default under the Debenture, the conversion
price may never be less than $2.00.
Any time after the six-month anniversary of the
issuance of the Debentures that the daily VWAP is less than $2.00 for a period of twenty consecutive trading days (the "Triggering
Date") and only for so long as such conditions exist after a Triggering Date, the Company shall make monthly payments beginning
on the last calendar day of the month when the Triggering Date occurred. Each monthly payment shall be in an amount equal to the
sum of (i) the principal amount outstanding as of the Triggering Date divided by the number of such monthly payments until maturity,
(ii) a redemption premium of 20% in respect of such principal amount and (iii) accrued and unpaid interest hereunder as of each
payment date. The Company may, no more than twice, obtain a thirty-day deferral of a monthly payment due as a result of a Triggering
Date through the payment of a deferral fee in the amount equal to 10% of the total amount of such monthly payment. Each deferral
payment may be paid at the option of the Company in cash or by the issuance of such number of shares as is equal to the applicable
deferral payment divided by a price per share equal to 93% of the average of the four lowest daily VWAPs during the 10 consecutive
Trading Days immediately preceding the due date in respect of such monthly payment being deferred, provided that such shares issued
will be immediately freely tradable shares in the hands of the holder.
Upon issuance of the Debentures, the Company recognized
a debt discount of approximately $331,000, resulting from the recognition of issuance costs of $35,000 and a bifurcated embedded
derivative of $296,000.   The monthly payment provision within the Debentures is a contingent put option that is required
to be separately measured at fair value, with subsequent changes in fair value recognized in the Condensed Consolidated Statement
of Operations. The fair value estimate is a Level 3 measurement. The Company estimated the fair value of the monthly payment provision
by estimating the probability of the occurrence of a Triggering Date and applying the probability to the discounted maximum
redemption premium for any given payment with the following key inputs:
F-
27
Q BIOMED INC.
Notes to Condensed Consolidated Financial Statements
January 15, 2020
December 6, 2019
Strike price
$
3.00
$
3.00
Terms (years)
1.4
1.5
Volatility
97%
98%
Risk-free rate
1.7%
1.6%
Dividend yield
0%
0%
The fair value of the monthly payment provision in all outstanding debentures
with the feature are revalued as of February 29, 2020 based on the following key inputs:
February 29, 2020
Strike price
$1.00 - $3.00
Terms (years)
1.0
Volatility
101%
Risk-free rate
1.0%
Dividend yield
0%
Debt Conversion
The following table summarizes debt conversion during
the three months ended February 29, 2020:
Principal value of 2018 Debenture
$
965,000
Accrued interest
85,000
Fair value of bifurcated contingent put option
86,000
Sub-total
$
1,136,000
Fair value of common stock issued (974,871 shares)
$
1,136,000
Interest expense
Interest expense, included in the accompanying Condensed
Consolidated Statements of Operations, is comprised of the following for each period presented:
For
    the Three Months ended
February
    29, 2020
February
    28, 2019
Interest expense based on the coupon interest rate of the outstanding debt
$
107,000
$
55,000
Accretion of debt discount
91,000
236,000
Total interest expense
$
198,000
$
291,000
Note 6 - Commitments and Contingencies
Legal
Periodically, the Company reviews the status of
significant matters, if any exist, and assesses its potential financial exposure. If the potential loss from any claim or legal
claim is considered probable and the amount can be estimated, the Company accrues a liability for the estimated loss.  Legal
proceedings are subject to uncertainties, and the outcomes are difficult to predict.  Because of such uncertainties, accruals
are based on the best information available at the time.  As additional information becomes available, the Company reassesses
the potential liability related to pending claims and litigation.
F-
28
Q BIOMED INC.
Notes to Condensed Consolidated Financial Statements
Advisory Agreements
The Company entered into customary consulting arrangements
with various counterparties to provide consulting services, business development and investor relations services, pursuant to which
the Company agreed to issue shares of common stock as services are received.
Office Facility Agreement
In December 2016, the Subsidiary entered
into a license to occupy a shared office facility in Cayman Islands for $30,000 per annum.  The initial term of the agreement ended
in December 2019 and the Company renewed the agreement for another three years with the same terms.
This agreement does not identify a specific
asset and does not convey the use of substantially all of the shared office capacity. As such, this agreement does not contain
a lease under ASC 842. The Company recognizes monthly license payments as incurred over the term of the arrangement.
The associated expense is classified within
general and administrative expenses.
Note 7 - Related Party Transactions
The Company entered into consulting agreements with
certain management personnel and stockholders for consulting and legal services. Consulting and legal expenses resulting from such
agreements were included within general and administrative expenses in the accompanying Condensed Consolidated Statements of Operations
as follows:
For
    the Three Months ended
February
    29, 2020
February
    28, 2019
Consulting and legal expenses
$
105,000
$
102,000
Note 8 - Stockholders' Equity Deficit
Issuance of shares for services
During the three months ended February 29, 2020, the
Company issued an aggregate of 60,141 shares of the Company common stock to various vendors for advisory services, valued at approximately
$0.1 million based on the estimated fair market value of the stock on the date of grant and was recognized within general and administrative
expenses in the accompanying Condensed Consolidated Statements of Operations.
Note 9 - Warrants and Options
Summary of warrants
The following represents a summary of all outstanding
warrants to purchase the Company's common stock, including warrants issued to vendors for services and warrants issued as
part of the units sold in the private placements, at February 29, 2020 and the changes during the period then ended:
F-
29
Q BIOMED INC.
Notes to Condensed Consolidated Financial Statements
Weighted Average
Weighted Average
Remaining
Contractual
Warrants
Exercise
    Price
Life
    (years)
Intrinsic
    Value
Outstanding at December 1, 2019
7,180,000
$
2.22
3.2
$
2,463,000
Issued
2,631,000
2.14
4.9
—
Cashless exercise
(30,000
)
0.86
—
—
Forfeited/expired
(246,000
)
4.01
—
—
Outstanding at February 29, 2020
9,535,000
$
2.14
3.5
$
8,680,000
Exercisable at February 29, 2020
9,497,000
$
2.14
3.5
$
8,656,000
On February 10, 2020, the Company issued 885,000 warrants
to certain consultants and service providers in exchange for services rendered. The warrants are exercisable into shares of the
Company's common stock for five years from the date of issuance at an exercise price of $2.12 per share.
On February 10, 2020, the Company issued 1,500,000
warrants to the Company's two officers in exchange for services rendered. The warrants are exercisable into shares of the
Company's common stock in six months from their issuance until five years from the date of issuance at an exercise price
of $2.12 per share.
The following assumptions were used to compute the
fair value of warrants granted during the three months ended February 29, 2020:
For the Three Months
ended
February 29, 2020
Strike price
$
2.12
Term (years)
5.0
Volatility
120%
Risk-free rate
1.4%
Dividend yield
0.0%
Modification of Warrants
On February 12, 2020, the Company modified an aggregated
of 245,625 warrants (the "Warrants") that were originally granted to certain investors and consultants. The exercise
price of the Warrants was reduced to $2.33 per share and the term of the Warrants were extended for 2 years from the original maturity
date.
The Company received $20,000 cash from one of the investors
as consideration for this modification. The Company immediately recognized approximately $0.1 million incremental stock-based compensation
on February 12, 2020 based on the following weighted average assumptions:
After Modification
Before Modification
Strike price
$
2.33
$
4.40
Term (years)
4.1
2.1
Volatility
122%
155%
Risk-free rate
1.4%
1.5%
Dividend yield
0.0%
0.0%
F-
30
Q BIOMED INC.
Notes to Condensed Consolidated Financial Statements
Options Issued for Services
The following represents a summary of all outstanding
options to purchase the Company's common stock at February 29, 2020 and the changes during the period then ended:
Weighted
    Average
Weighted
    Average
Remaining
Contractual
Options
Exercise
    Price
Life
    (years)
Intrinsic
    Value
Outstanding at December 1, 2019
1,200,000
$
1.35
3.4
$
453,000
Issued
150,000
1.50
4.8
—
Outstanding at February 29, 2020
1,350,000
$
1.37
3.3
$
1,965,000
Exercisable at February 29, 2020
1,230,000
$
1.35
3.2
$
1,810,000
Stock-based Compensation
The Company recognized general and administrative expenses
of approximately $4.5 million and $0.16 million as a result of the shares, outstanding warrants and options issued to consultants
and employees during the three months ended February 29, 2020 and February 28, 2019, respectively.
As of February 29, 2020, the estimated unrecognized
stock-based compensation associate with these agreements is approximately $0.12 million and will be fully recognized over the next
12 months.
Note 10 – Subsequent events
Amendments to Articles of Incorporation or Bylaws
On April 3, 2020, the Company's
Board of Directors authorized the creation of up to 500,000 shares of Class A Convertible Preferred Stock (the "Class A Preferred
Shares") and up to 1,000,000 shares of Class B Convertible Preferred Stock (the "Class B Preferred Shares").
On April 6, 2020, the Company filed a Certificate of Designations with the Secretary of Nevada creating such Class A and Class
B Preferred Shares
Financing Agreements
On April 6, 2020, the Company entered into a securities
purchase agreement (the "SPA") with accredited investors (the "Investors"). Pursuant to the SPA, the Investors
agreed to purchase:
•
76,566 shares of Series A Convertible
Preferred Stock (the "Series A Preferred Shares") in exchange for convertible debentures with principal and interest
of $765,656
•
100,000 Series A Preferred Shares
for cash of $1,000,000,
•
203,134 shares of Series B Convertible
Preferred Stock ('the "Series B Preferred Shares") in exchange for convertible debentures with principal and
interest of $2,031,342
•
100,000 Series B Preferred Shares
for cash of $1,000,000 and
•
on April 17, 2020, 200,000 Series
B Preferred Shares for $2,000,000 in cash.
By April 17, 2020, the Investors have the right
to convert all remaining unconverted debt into 51,432 Series A Preferred Shares.
Debt Conversion
In March 2020, the Company converted approximately
$1.2 million outstanding debt and interest into 1,110,497 shares of common stock.
F-
31
PROSPECTUS
Q BIOMED INC.
1,836,286 Shares of Common Stock
underlying
Series A Preferred Shares
3,163,714 Shares of Common Stock underlying
Series A Preferred Shares
[[♦] [♦], 2020]
Until [[♦], 2020] (the 90th day
after the date of this prospectus), all dealers that buy, sell or trade our common stock, whether or not participating in this
offering, may be required to deliver a prospectus. This delivery requirement is in addition to the dealers' obligation to
deliver a prospectus when acting as underwriters and with respect to unsold allotments or subscriptions.
No dealer, salesperson or other individual
has been authorized to give any information or to make any representations not contained in this prospectus in connection with
the offering covered by this prospectus. If given or made, such information or representations must not be relied upon as having
been authorized by us. This prospectus does not constitute an offer to sell, or a solicitation of an offer to buy the offered securities
in any jurisdiction where, or to any person to whom, it is unlawful to make any such offer or solicitation. Neither the delivery
of this prospectus nor any offer or sale made hereunder shall, under any circumstances, create an implication that there has not
been any change in the facts set forth in this prospectus or in our affairs since the date hereof.
PART II
INFORMATION NOT REQUIRED IN THE PROSPECTUS
ITEM
13. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.
The table below itemizes the expenses payable
by the registrant in connection with the registration and issuance of the securities being registered hereunder, other than underwriting
discounts and commissions. All amounts except the Securities and Exchange Commission registration fee are estimated.
Securities and Exchange Commission Registration Fee
$
1,320
Legal Fees and Expenses
$
20,000
Accountants' Fees and Expenses
$
5,000
Total
$
26,320
ITEM
14. INDEMNIFICATION OF DIRECTORS AND OFFICERS.
Our officers and directors are indemnified
under Nevada law. Our Amended and Restated Articles of Incorporation and our Bylaws are silent as to director and officer indemnification
other than to allow such indemnification to the greatest extent permitted by Nevada law.
Nevada Revised Statute. The registrant
is a Nevada corporation.
Section 78.138 of the Nevada Revised Statutes
provides that a director or officer will not be personally liable to the corporation and its stockholders unless it is proven that
(i) the director's or officer's acts or omissions constituted a breach of his fiduciary duties, and (ii) such breach involved intentional
misconduct, fraud or a knowing violation of the law. The provisions of the Nevada Revised Statutes with respect to limiting personal
liability for directors and officers are self-executing and, to the extent the provisions of our Amended and Restated Articles
of Incorporation and By-laws would be deemed to be inconsistent therewith, the provisions of the Nevada Revised Statutes will control.
Section 78.7502 of the Nevada Revised
Statutes permits a corporation to indemnify a present or former director, officer, employee or agent of the corporation, or of
another entity or enterprise for which such person is or was serving in such capacity at the request of the corporation, who was
or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, except an
action by or in the right of the corporation, against expenses, including attorneys' fees, judgments, fines and amounts paid
in settlement actually and reasonably incurred in connection therewith, arising by reason of such person's service in such
capacity if such person (i) is not liable pursuant to Section 78.138 of the Nevada Revised Statutes, or (ii) acted
in good faith and in a manner which he or she reasonably believed to be in or not opposed to the best interests of the corporation
and, with respect to a criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful. In the
case of actions brought by or in the right of the corporation, however, no indemnification may be made for any claim, issue or
matter as to which such person has been adjudged by a court of competent jurisdiction, after exhaustion of all appeals therefrom,
to be liable to the corporation or for amounts paid in settlement to the corporation, unless and only to the extent that the court
in which the action or suit was brought or other court of competent jurisdiction determines upon application that in view of all
the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses as the court deems
proper.
Section 78.751 of the Nevada Revised
Statutes permits any discretionary indemnification under Section 78.7502 of the Nevada Revised Statutes, unless ordered by
a court or advanced to a director or officer by the corporation in accordance with the Nevada Revised Statutes, to be made by a
corporation only as authorized in each specific case upon a determination that indemnification of the director, officer, employee
or agent is proper in the circumstances. Such determination must be made (1) by the stockholders, (2) by the board of
directors by majority vote of a quorum consisting of directors who were not parties to the action, suit or proceeding, (3) if
a majority vote of a quorum consisting of directors who were not parties to the action, suit or proceeding so orders, by independent
legal counsel in a written opinion, or (4) if a quorum consisting of directors who were not parties to the action, suit or
proceeding cannot be obtained, by independent legal counsel in a written opinion.
II-
1
ITEM
15. SALES OF UNREGISTERED SECURITIES IN PAST THREE YEARS.
On June 5, 2017, we issued warrants to
purchase up to 350,000 shares of our common stock to each of Denis Corin, our President and Chief Executive Officer, and William
Rosenstadt, our Chief Legal Officer. The warrants were issued as a bonus for their business development services to the Company
over the last 12 months. The warrants, as amended in September 2019, are exercisable for five years at a per share price of $1.25.
The warrants may not be exercised within the first six months of their issuance.
On June 5, 2017, we issued warrants to
purchase up to 150,000 shares of our common stock to each of Ari Jatwes and David Laskow Pooley as a bonus for their business development
services to the Company over the last 12 months. The warrants are exercisable for five years at a per share price of $4.00. The
warrants may not be exercised within the first six months of their issuance.
On June 5, 2017, we issued options to purchase
up to 150,000 shares of our common stock to each of Denis Corin, our President and Chief Executive Officer, and William Rosenstadt,
our Chief Legal Officer. 50,000 of the options were issued as compensation for their continued services on our board of directors
through June 1, 2018 and 100,000 of the options were issued as compensation as officers through June 1, 2018. 37,500 of the options
vest on September 1, 2017, 37,500 of the options vest on December 1, 2017, 37,500 of the options vest on March 1, 2018 and 37,500
of the options vest on June 1, 2018. The options, as amended in September 2019, are exercisable for five years at a per share price
of $1.25. The options may not be exercised within the first six months of vesting.
On June 5, 2017, we issued warrants to
purchase up to 25,000 shares of our common stock to a consultant as a bonus for their business development services to the Company
over the last 12 months. The warrants are exercisable for five years at a per share price of $4.00. The warrants may not be exercised
within the first six months of their issuance.
On June 5, 2017, we issued warrants to
purchase up to 10,000 shares of our common stock to a consultant as a bonus for accounting services to the Company over the last
12 months. The warrants are exercisable for five years at a per share price of $4.00. The warrants may not be exercised within
the first six months of their issuance.
On August 1, 2017, we issued 953,249 units
in exchange for $3,050,390, which included payment through the retirement of $518,400 of outstanding debt.  Each unit consisted
of two shares of our common stock and a warrant to purchase a share of our common stock at $4.50. We also issued 39,246 warrants
to the placement agents in the August 1, 2017 transaction pursuant to the placement agents agreement to which the placement agents
and we are parties.
On October 3, 2017, we issued 25,641 restricted
shares of our common stock to the holder of the Debentures as consideration for extending the maturity date of the Debentures from
November 30, 2017 to November 30, 2018.
In September and October 2017, we issued
an aggregate of 31,000 shares of its common stock to our vendors for services.
On October 16, 2017, we issued 146,662
shares of our common stock to the holder of a convertible notes issued on March 10, 2017 upon the conversion of $500,445 of principal
and interest of such note.
On November 2, 2017, the Company issued
46,875 shares of its common stock in full settlement of $150,000 in principal and interest due to an entity as a result of promissory
notes issued by it in November 2016.
On November 22, 2017, we issued 166,592
shares of our common stock to the holder of a convertible notes issued on November 29, 2016 and March 10, 2017 upon the conversion
of $551,771 of principal and interest of such notes.
On November 23, 2017, we issued 13,200
shares of our common stock to an investor upon its conversion of $30,000 in principal in, and $3,000 in interest on, a convertible
note purchased from us on November 22, 2016.
II-
2
On November 29, 2017, we issued 270,270
shares of our common stock to the holder of a convertible notes issued on November 29, 2016 upon the conversion of $1,000,000 of
principal of such note and the waiver and release of any other amounts or obligations, including interest, due under such note,
a convertible note issued on March 10, 2017 and a convertible note issued on April 7, 2017.
On February 13, 2018, we issued options
to acquire up to 50,000 shares of our common stock to our independent director. The options will vest in quarterly installments
of 12,500 each and are exercisable for 5 years at $3.00 per option.
On March 1, 2018, we issued 27,000 shares
to a third-party service provider in exchange for services.
On June 1, 2018, we issued 50,000 options
to each of Denis Corin and William Rosenstadt for their continued services as directors of our company. Each option is to purchase
a share of our common stock for $1.25 per share, as amended in September 2019. The options vest in quarterly amounts on May 31,
2018, September 1, 2018, December 1, 2018 and March 1, 2019.
On June 1, 2018, we issued 100,000 options
to each of Denis Corin and William Rosenstadt for their continued services as officers of our company. Each option is to purchase
a share of our common stock for $1.25 per share, as amended in September 2019. The options vest in quarterly amounts on May 31,
2018, September 1, 2018, December 1, 2018 and March 1, 2019.
On June 1, 2018, we entered into a new
agreement with a consultant to provide expertise in the areas of technology assessment and product development. In exchange for
such services, the consultant will receive warrants to purchase a share of our common stock exercisable at $3.61 per share.
In June 2018, we entered into an agreement
with a consultant to provide expertise in the areas of commercial marketing. In exchange for such services, each month for the
twelve months of the agreement the consultant will receive shares of our common stock equal to $22,000 divided by the market price
of our common stock on the first day of such month.
On July 9, 2018, we issued options to purchase
50,000 shares of our common stock at $3.61 per option to each of two advisors in exchange for consulting services. The options
vest in quarterly amounts every three months.
On September 21, 2018, we issued a convertible
note in the face amount of $2,000,000 which bears interest at 5.5% per annum. The convertible note may be converted into shares
of our common stock at
the lesser of (i) $4.00 and (ii) 93%
of the four
lowest daily volume weighted average prices of the Company's common stock (as reported by Bloomberg) during the last ten
trading days immediately preceding the date of such conversion
, but in no event will the
conversion price be less than $2.00.
On September 21, 2018, we issued 25,000
shares in connection with the waiver of a right of first refusal for the sale of the September 2018 convertible debentures mentioned
above.
On September 21, 2018, we issued 25,000
shares for advisory services in connection with the sale of the September 2018 convertible debentures mentioned above.
On September 21, 2018, we issued 25,000
shares in connection with legal services provided to us.
On September 21, 2018, we issued 38,049
shares of common stock to four consultants, including a member of our board and two members of our board of advisors, for consulting
services.
In October 2018, we issued 50,000 shares
to BNI in compliance with our license agreement.
In November 2018, we issued 49,875 shares
to our consultants in exchange for consulting services.
On November 1, 2018, we issued a convertible
note in the face amount of $2,000,000 which bears interest at 5.5% per annum. The convertible note, as amended on September 23,
2019, may be converted into shares of our common stock at
the lesser of (i) $1.00 and
(ii) 93%
of the four lowest daily volume weighted average prices of the Company's common stock (as reported by
Bloomberg) during the last ten trading days immediately preceding the date of such conversion
,
but in no event will the conversion price be less than $0.50, or (
iii) a price agreed to by us and the investor
.
II-
3
On January 4, 2019, we issued an aggregate of 175,919 shares
of the Company common stock to various vendors for advisory services.
On April 9, 2019, we issued an aggregate
of 185,128 shares of the Company's common stock to various vendors for advisory services and the extension of the Mannin
Purchase Option Agreement.
On March 26, 2019, we entered into an amendment to the Patent
and Technology License and Purchase Option Agreement that it initially entered into with Mannin Research Inc. on October 29, 2015.
Pursuant to such amendment, the Company issued 100,000 shares to Mannin Research Inc. in exchange for the term of the option granted
under the agreement extending to October 29, 2021.
In March 2019, we issued an aggregate of 386,900 shares of the
Company's common stock to various vendors for advisory services.
On August 28, 2019, we issued a convertible
debenture in the face amount of $550,000 which bears interest at 10% per annum. The debenture is convertible at any time at the
conversion price of $2.50 per share. At any time that is six months after the issuance, a portion of the Debenture is redeemable,
not to exceed $150,000 in any month. We may pay such a redemption in cash and/or shares of common stock. Any payment of such a
redemption in shares of common stock shall be made at the lesser of $2.50 or 93% of the average of the four lowest VWAPs in the
prior ten trading day, provided that no such conversion price shall be less than $2.00. Any payment of such a redemption in cash
shall be at 120% of the amount being redeemed.
On
August 13, 2019, we issued 365,450 shares of our common stock to the holder of a convertible note issued on September 21, 2018
upon conversion of $326,164 of principal and interest of such note.
On September 23, 2019, we issued 50,000
shares of our common stock to BioNucleonics, Inc. pursuant to a settlement agreement dated September 23, 2019.
On
September 24, 2019, we issued 667,095 shares of our common stock to the holder of a convertible note issued on November 1, 2018
upon conversion of $333.547.95 of principal and interest of such note.
On
September 24, 2019, we issued warrants to purchase 50,000 shares of our common stock to Ari Jatwes for services as a consultant.
The warrants are exercisable for a term of 5 years from the date of issuance at a price of $1.25 per share.
On
September 24, 2019, we issued warrants to purchase 50,000 shares of our common stock to Riccardo Panicucci for services as a director.
The warrants are exercisable for a term of 5 years from the date of issuance at a price of $1.25 per share.
On
September 24, 2019, we issued warrants to purchase 84,000 shares of our common stock to Access! Association for business development
services pursuant to a consulting agreement. The warrants are exercisable for a term of 3 years from the date of issuance at a
price of $1.25 per share.
On
September 24, 2019, we issued warrants to purchase 100,000 shares of our common stock to Rajendra Apte for business development
services as a consultant. The warrants are vested in equal portions quarterly (12,500 warrants per quarter) and are exercisable
for a term of 5 years from the date of issuance at a price of $1.25 per share.
In September 2019, we issued additional
201,157 units (and the corresponding underlying securities) to various investors who had purchased $180,750 of units, each unit
consisting of one share of common stock and one warrant to purchase a share of common stock, at $2.00 per unit in May 2019. Pursuant
to these amendments, the unit purchase price was reduced to $0.62 and the exercise price of warrants in the units was reduced to
$0.86.
II-
4
In September 2019, we entered into a series
of related Securities Purchase Agreements with seven investors for a total of $208,250. Pursuant to the terms of the investment,
such investors received 335,887 shares of our common stock and 503,831 warrants to purchase shares of our common stock at an exercise
price of $0.86.
On October 7, we issued 496,109 shares
of common stock upon the conversion of $198,443.84 of principal and interest of a convertible note issued by us in September 2018.
On October 11,
2019, we issued a convertible debenture in the face amount of $500,000 which bears interest at 5.5% per annum. The convertible
debenture may be converted into shares of our common stock at
the lesser of
$1.00
or 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately preceding the conversion
date, provided that as long as we are not in default under the Debenture, the conversion price may never be less than $0.50.
In October 2019, we issued 148,261 units
(with each unit consisting of one share of common stock and 1.5 warrants to purchase a share of common stock) to our legal counsel
in exchange for $91,922 of services provided. Our Chief Legal Officer and a Director is the Managing Partner at the law firm where
these services were provided.
In October and November 2019, we entered
into a series of securities purchase agreements for the sale of 1,185,715 units at a $0.35 per unit sales price. Each unit consisted
of one share and one warrant to purchase a share of common stock at an exercise price of $0.50.
In November 2019, we converted $20,000
of outstanding debt due to one of our directors into 40,000 shares of common stock and $20,000 of outstanding debt due to a consultant
into 40,000 shares of common stock.
On November 20, 2019, we issued 831,481
shares to a note holder in exchange for the conversion of $415,740.82 of principal and interest on convertible notes.
On November 25, 2019, we issued 500 shares
to a director in exchange for services.
On November 25, 2019, we issued 254,442
shares to five consultants pursuant to consulting agreements.
On November 25, 2019, we issued 377,834
shares pursuant to a research collaboration and master services agreement with Chemveda Life Sciences India Private Limited.
On November 25, 2019, we issued 150,000
shares due to BioNucleonics, Inc. pursuant to a September 23, 2019 Settlement Agreement.
On December 2, 2019, we issued 503,295
shares to a note holder in exchange for the conversion of $251,674.74 of principal and interest on convertible notes.
On December 5, 2019, we issued 150,000
options to Ricardo Panicucci for his continued services as a director of our company. Each option is to purchase a share of our
common stock for $1.50 per share. One-fifth of the options vested immediately and an additional fifth vests each quarter thereafter.
On December 6,
2019, we issued a convertible debenture in the face amount of $1,000,000 which bears interest at 5.5% per annum. The convertible
debenture may be converted into shares of our common stock at
the lesser of
$3.00
or 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately preceding the conversion
date, provided that the conversion price may never be less than $2.00.
On December 31, 2019, we issued 204,653
shares of common stock to a note holder in exchange for the conversion of $204,653.15 of principal and interest on convertible
notes.
On January 15,
2020, we issued a convertible debenture in the face amount of $1,000,000 which bears interest at 5.5% per annum. The convertible
debenture may be converted into shares of our common stock at
the lesser of
$3.00
or 93% of the average of the four lowest daily VWAPs during the 10 consecutive trading days immediately preceding the conversion
date, provided that the conversion price may never be less than $2.00.
On January 31, 2020, we issued 378,573 shares to a note holder
in exchange for the conversion of $378,573.49 of principal and interest on convertible notes.
On February 10, 2020, we issued 885,000
warrants to 11 consultants and service providers in exchange for services rendered. The warrants are exercisable into shares of
the Company's common stock for five years from the date of issuance at an exercise price of $2.12 per share.
On February 10, 2020, we issued 1,500,000
warrants to two officers in exchange for services rendered. The warrants are exercisable into shares of the Company's common
stock in six months from their issuance until five years from the date of issuance at an exercise price of $2.12 per share.
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On February 28, 2020, we issued 391,645
shares to a note holder in exchange for the conversion of $391,645.48 of principal and interest on convertible notes.
On March 31, 2020, we issued 1,050,496
shares to a note holder in exchange for the conversion of $1,050,496.78 of principal and interest on convertible notes.
On April 6, 2020, we issued 176,566 shares
of Series A Convertible Preferred Stock and 303,134 shares of Series B Convertible Preferred Stock to the holder of convertible
notes in exchange for conversion of $2,796,999 of principal and interest on convertible notes and cash of $2,000,000.
On April 7, 2020, we issued 250,000 warrants
in exchange for legal services, which warrants are exercisable for five years into 250,000 shares of common stock at an exercise
price of $2.12 per share.
On April 17, 2020, we issued 200,000 shares
of Series B Convertible Preferred Stock in exchange for cash of $2,000,000.
The issuances
of the securities mentioned above qualified for the exemption from registration contained in Section 4(2) of the Securities Act
of 1933.
ITEM
16. EXHIBITS.
Exhibit
No.
Description
3.1
Articles of Incorporation filed as Exhibit 3 (a) to Form S-1 filed on January 13, 2014 and incorporated herein by reference
3.2
Amendment to Articles of Incorporation, dated July 20, 2015, filed as Exhibit 3.1 to our periodic report filed on Form 8-K on August 3, 2015 and incorporated herein by reference
3.3
Amendment to Articles of Incorporation, dated October 27, 2015, filed as Exhibit 3.1 to our periodic report filed on Form 8-K on October 29, 2015 and incorporated herein by reference
3.4
Articles of Incorporation filed as Exhibit 3 (b) to Form S-1 filed on January 13, 2014 and incorporated herein by reference
3.5
Certificate of Designation for Series A Convertible Preferred Stock, dated April 6, 2020, filed as Exhibit 3.1 to our Form 8-K on April 7, 2020 and incorporated herein by reference
3.6
Certificate of Designation for Series B Convertible Preferred Stock, dated April 6, 2020, filed as Exhibit 3.2 to our Form 8-K on April 7, 2020 and incorporated herein by reference
4.1
Form of Warrant in connection with our February 1, 2018 offering filed as Exhibit 4.1 to our registration statement on Form S-1 filed on January 12, 2018
4.2
Form of Warrant as filed as Exhibit 4.2 to our current report on Form 8-K filed on June 9, 2017 and incorporated herein by reference
4.3
Form of Warrant as filed as Exhibit 10.3 to our current report on Form 8-K filed on August 2, 2017 and incorporated herein by reference
5.1
Opinion of Ortoli Rosenstadt LLP*
10.1
Form of Non-Institutional Promissory Note filed as Exhibit 10.1 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference
10.2
Stock Purchase Agreement for Institutional Promissory Note, dated January 8, 2016, with CMGT filed as Exhibit 10.2 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference
10.3
Form of Institutional Promissory Note filed as Exhibit 10.4 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference
10.4
Advisory Agreement, dated September 8, 2015, with Wombat Capital Ltd. filed as Exhibit 10.5 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference
10.5
Advisory Agreement, dated June 1, 2015, with Ari Jatwes filed as Exhibit 10.6 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference
10.6
Consulting Agreement, dated November 13, 2015, Pharmafor Ltd. filed as Exhibit 10.7 to our current report on Form 8-K filed on January 13, 2016 and incorporated herein by reference
10.7
Executive Services Agreement, dates June 1, 2017, between Denis Corin and Q BioMed Cayman SEZC filed as Exhibit 10.1 to our current report on Form 8-K filed on June 9, 2017 and incorporated herein by reference
10.9
Form of Non-Qualified Stock Option Agreement filed as Exhibit 4.1 to our current report on Form 8-K filed on June 9, 2017 and incorporated herein by reference
10.10
Patent and Technology License and Purchase Option Agreement, dated October 29, 2015, with Mannin Research Inc. filed as Exhibit 10.1 to our annual report on Form 10-K filed on March 11, 2016 and incorporated herein by reference +
10.11
Patent and Technology License and Purchase Option Agreement, dated May 30, 2016, with Bio-Nucleonics Inc., filed as Exhibit 10.1 to our quarterly report on Form 10-Q filed on October 17, 2016 and incorporated herein by reference +
10.12
First Amendment to Patent and Technology License and Purchase Option Agreement, dated September 6, 2016, with Bio-Nucleonics Inc., filed as Exhibit 10.2 to our quarterly report on Form 10-Q filed on October 17, 2016 and incorporated herein by reference +
10.13
License Agreement on Patent & Know-How Technology, dated April 21, 2017, between Q BioMed Inc. and ASDERA LLC filed as Exhibit 10.1 to our quarterly report on Form 10-Q filed on April 25, 2017 and incorporated herein by reference +
10.14
Executive Services Agreement, dated June 5, 2017, between Q BioMed Cayman SEZC and Denis Corin filed as Exhibit 10.1 to our current report on Form 8-K filed on June 9, 2017 and incorporated herein by reference
10.15
Technology License Agreement, dated June 15, 2017, among Q BioMed Inc., Oklahoma Medical Research Foundation and Rajiv Gandhi Centre for BioTechnology filed as Exhibit 10.1 to our current report on Form 8-K filed on June 15, 2017 and incorporated herein by reference +
10.16
Form of Placement Agent Agreement in connection with our February 1, 2018 offering filed as Exhibit 10.15 to our registration statement on Form S-1 filed on January 12, 2018
10.17
Form of Securities Purchase Agreement in connection with our February 1, 2018 offering filed as Exhibit 10.16 to our registration statement on Form S-1 filed on January 12, 2018
10.18
Securities Purchase Agreement, dated September 21, 2018, filed as Exhibit 10.1 to our current report on Form 8-K filed on September 24, 2018 and incorporated herein by reference
10.19
Asset Purchase Agreement with GE Healthcare Limited, dated November 23, 2018, filed as Exhibit 10.1 to our current report on Form 8-K filed on November 28, 2018 and incorporated herein by reference++
10.20
Securities Purchase Agreement, dated August 28, 2019, filed as Exhibit 10.1 to our current report on Form 8-K (as amended) on September 6, 2019 and incorporate herein by reference
10.21
Form of Debenture pursuant to the Securities Purchase Agreement entered into on August 28, 2019, filed as Exhibit 10.2 to our current report on Form 8-K (as amended) on September 6, 2019 and incorporate herein by reference
10.22
Securities Purchase Agreement, dated October 11, 2019, filed as Exhibit 10.1 to our current report on Form 8-K on October 15, 2019 and incorporate herein by reference
10.23
Form of Debenture pursuant to the Securities Purchase Agreement entered into on October 11, 2019, filed as Exhibit 10.2 to our current report on Form 8-K on October 15, 2019 and incorporate herein by reference
10.24
Securities Purchase Agreement, dated December 5, 2019, filed as Exhibit 10.1 to our current report on Form 8-K on December 12, 2019 and incorporate herein by reference
10.25
Form of Debenture pursuant to the Securities Purchase Agreement entered into on December 5, 2019, filed as Exhibit 10.2 to our current report on Form 8-K on December 12, 2019 and incorporate herein by reference
10.26
Securities Purchase Agreement in connection with our April 6, 2020 private placement of Preferred Shares filed as Exhibit 10.1 to our current report on Form 8-k filed on April 7, 2020
10.27
Registration Rights Agreement filed as Exhibit 10.2 to our current report on Form 8-k filed on April 7, 2020
21.1
List of Subsidiaries*
23.1
Consent of Ortoli Rosenstadt (included in Exhibit 5.1)
23.2
Consent of Marcum LLP*
24.1
Power of Attorney (included on the signature page to this Registration Statement)
*Filed herewith
+ Portions of this exhibit have been omitted pursuant to
a request for confidential treatment, and the SEC has granted confidential treatment pursuant to Rule 406 under the Securities
Act. Confidential information has been omitted from the exhibit in places marked "****"and has been filed separately
with the SEC.
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ITEM
17. UNDERTAKINGS.
(a)
RULE 415 OFFERING
The undersigned registrant hereby undertakes:
(1)  To file, during any period
in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)
To include any prospectus required by Section 10(a)(3)
of the Securities Act of 1933, as amended;
(ii)
To reflect in the prospectus any facts or events arising
after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually
or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding
the foregoing, any increase or decrease in the volume of securities offered (if the total dollar value of securities offered would
not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be
reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b)) if, in the aggregate, the changes in volume
and price represent no more than 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration
Fee" table in the effective registration statement; and
(iii)
To include any material information with respect to
the plan of distribution not previously disclosed in the registration statement or any material change to such information in
the registration statement;
(2)  That, for the purpose of
determining any liability under the Securities Act of 1933, as amended, each such post- effective amendment shall be deemed to
be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall
be deemed to be initial bona fide offering thereof.
(3)  To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(4)  That, for the purpose of
determining liability under the Securities Act of 1933, as amended, to any purchaser:
(A) Each prospectus filed by the registrant
pursuant to Rule 424(b)(3) shall be deemed to be part of the Registration Statement as of the date the filed prospectus was deemed
part of and included in the Registration Statement; and
(B) Each prospectus required to be filed
pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a Registration Statement in reliance on Rule 430B relating to an offering
made pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by Section 10(a) of the
Securities Act of 1933, as amended, shall be deemed to be part of and included in the Registration Statement as of the earlier
of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities
in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that
is at that date an underwriter, such date shall be deemed to be a new effective date of the Registration Statement relating to
the securities in the Registration Statement to which that prospectus relates, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof. Provided, however, that no statement made in a Registration Statement
or prospectus that is part of the Registration Statement or made in a document incorporated or deemed incorporated by reference
into the Registration Statement or prospectus that is part of the Registration Statement will, as to the purchaser with a time
of contract of sale prior to such effective date, supersede or modify any statement that was made in the Registration Statement
or prospectus that was part of the Registration Statement or made in any such document immediately prior to such effective date.
(5)  That, for the purpose of
determining liability of the registrant under the Securities Act of 1933, as amended, to any purchaser in the initial distribution
of the securities, the undersigned registrant undertakes that in a primary offering of securities of the undersigned registrant
pursuant to this Registration Statement, regardless of the underwriting method used to sell the securities to the purchaser, if
the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned registrant
will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:
(i)
Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering
required to be filed pursuant to Rule 424;
(ii)
Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned
registrant or used or referred to by the undersigned registrant;
(iii)
The portion of any other free writing prospectuses relating to the offering containing material
information about the undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and
(iv)
Any other communication that is an offer in the offering made by the undersigned registrant to
the purchaser.
(h)  Insofar as indemnification
for liabilities arising under the Securities Act of 1933, as amended, may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion
of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant
of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered,
the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court
of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities
Act of 1933, as amended, and will be governed by the final adjudication of such issue.
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SIGNATURES
Pursuant to the requirements of the Securities Act of 1933,
the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized,
on April 28, 2020.
Q BioMed Inc.
By:
/s/ Denis Corin
Denis Corin
Chief Executive Officer (Principal Executive Officer), Chief Financial Officer (Principal Accounting Officer)
Pursuant to the requirements of the Securities
Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates
indicated. Each person in so signing also makes, constitutes and appoints Denis Corin, his or her true and lawful attorney-in-fact,
with full power of substitution, in any and all capacities, to execute and cause to be filed with the Securities and Exchange Commission
pursuant to the requirements of the Securities Act of 1933, as amended, any and all amendments and post-effective amendments to
this Registration Statement, with exhibits to such registration statements and amendments and other documents in connection therewith,
and hereby ratifies and confirms all that said attorney-in-fact or his or her substitute or substitutes may do or cause to be done
by virtue hereof.
Signature
Title
Date
/s/ William Rosenstadt
Director
April 28, 2020
William Rosenstadt
/s/ Denis Corin
Director
April 28, 2020
Denis Corin
/s/ Rick Panicucci
Director
April 28, 2020
Rick Panicucci
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