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<TITLE>Anadys Pharmaceuticals, Inc.</TITLE>
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<P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>

<DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
</DIV>


<P align="center" style="font-size: 10pt"><HR align="center" size="1" noshade width="25%">


<P align="center" style="font-size: 18pt"><B>FORM S-8</B>


<P align="center" style="font-size: 12pt"><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</B>



<P align="center" style="font-size: 12pt"><HR align="center" size="1" noshade width="25%">


<P align="center" style="font-size: 24pt"><B>Anadys Pharmaceuticals, Inc.</B>

<DIV align="center" style="font-size: 10pt">(Exact Name of Registrant as Specified in Its Charter)</DIV>


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<TR valign="bottom">
    <TD align="center" valign="top"><B>Delaware</B></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">(State or Other Jurisdiction of
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>22-3193172</B></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">Incorporation or Organization)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
</TR>


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<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">

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    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
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<TR valign="bottom">
    <TD align="center" valign="top"><B>3115 Merryfield Row</B></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><B>San Diego, California</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>92121</B></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">(Address of Principal Executive Offices)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(Zip Code)</TD>
</TR>


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<P align="center" style="font-size: 10pt"><B>Anadys Pharmaceuticals, Inc.<BR>
2004 Equity Incentive Plan<BR>
2004 Non-Employee Directors&#146; Stock Option Plan<BR>
2004 Employee Stock Purchase Plan</B><BR>
(Full title of the plan)



<P align="center" style="font-size: 10pt"><B>Elizabeth E. Reed, Esq.<BR>
Senior Director, Legal Affairs and Secretary<BR>
Anadys Pharmaceuticals, Inc.<BR>
3115 Merryfield Row<BR>
San Diego, California 92121</B><BR>
(Name and Address of Agent for Service)



<P align="center" style="font-size: 10pt"><B>(858)&nbsp;530-3600</B><BR>
(Telephone Number, Including Area Code, of Agent for Service)



<P align="center" style="font-size: 10pt"><HR align="center" size="1" noshade width="25%">



<P align="center" style="font-size: 10pt">Copy to:<BR>
<B>Thomas A. Coll, Esq.<BR>
Steven M. Przesmicki, Esq.<BR>
Cooley Godward LLP<BR>
4401 Eastgate Mall<BR>
San Diego, California 92121-9109<BR>
(858)&nbsp;550-6000</B>



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<P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">

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    <TD width="35%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="9%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="10%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="8%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="8%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Proposed</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Title of Each Class</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Proposed Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>of Securities to</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Amount to be</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Offering</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Aggregate</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Amount of</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>be Registered</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Registered (1)</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Price per Share (2)</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Offering Price (2)</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Registration Fee</B><HR size="1" noshade></TD>
</TR>


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<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px">Common Stock issuable
under the 2004 Equity
Incentive Plan (par value
$0.001 per share)</DIV></TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="center">779,333 shares</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">6.67</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">5,198,151.11</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">658.61</TD>
    <TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px">Common Stock issuable
under the 2004
Non-Employee Directors&#146;
Stock Option Plan (par
value $0.001 per share)</DIV></TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="center">111,333 shares</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">6.67</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">742,591.11</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">94.09</TD>
    <TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px">Common Stock issuable
under the 2004 Employee
Stock Purchase Plan (par
value $0.001 per share)</DIV></TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="center">334,000 shares</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">6.67</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">2,227,780.00</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">282.26</TD>
    <TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px"><B>Total</B></DIV></TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="center">1,224,666 shares</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">N/A</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">8,168,522.22</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">1,034.96</TD>
    <TD>&nbsp;</TD>
</TR>


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<TR valign="top">
    <TD width="1%" nowrap align="right">(1)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#147;1933 Act&#148;), this
Registration Statement also registers any additional shares of the Registrant&#146;s common stock, par
value $0.001 per share (the &#147;Common Stock&#148;), as may become issuable under any of the plans as a result
of any stock split, stock dividend, recapitalization or similar event.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="1%" nowrap align="right">(2)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">This estimate is made pursuant to Rule 457(h) of the 1933 Act solely for purposes of calculating the
registration fee. The price per share and aggregate offering price are based upon the average of the
high and low prices of Registrant&#146;s Common Stock on
November&nbsp;16, 2004, as reported on the Nasdaq
National Market.</TD>
</TR>

</TABLE>



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<P align="center" style="font-size: 10pt">&nbsp;
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<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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</TR>
<TR><TD colspan="9"><A HREF="#000">EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="#001">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#002">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="a03492exv5w1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a03492exv23w1.txt">EXHIBIT 23.1</A></TD></TR>
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<P align="center" style="font-size: 10pt"><B>INCORPORATION BY REFERENCE OF CONTENTS</B>



<P align="center" style="font-size: 10pt"><B>OF REGISTRATION STATEMENT ON FORM S-8 NO. 333-113954</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement is being filed for the purpose of increasing
the number of securities of the same class as other securities for which a
Registration Statement of the Registrant on Form S-8 relating to the same
employee benefit plans is effective. The Registrant previously registered
shares of its Common Stock for issuance under the 2004 Equity Incentive Plan,
2004 Non-Employee Directors&#146; Stock Option Plan, 2004 Employee Stock Purchase
Plan, and 2002 Equity Incentive Plan under a Registration Statement on Form
S-8, filed with the Securities and Exchange Commission (the &#147;SEC&#148;) on March&nbsp;26,
2004 (File No.&nbsp;333-113954). Pursuant to General Instruction E on Form S-8,
this Registration Statement incorporates by reference the contents of the
Registration Statement referenced above, except as otherwise set forth herein.

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<P align="center" style="font-size: 10pt"><B>EXHIBITS</B>


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    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Number</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Description</B><HR size="1" noshade></TD>
</TR>


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<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant, as amended. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Bylaws of the Registrant, as amended. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Certificate for the Registrant&#146;s Common Stock. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Cooley Godward LLP</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Cooley Godward LLP. Reference is made to Exhibit&nbsp;5.1.</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney is contained on the signature page.</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Anadys Pharmaceuticals, Inc. 2004 Equity Incentive Plan and form Stock
Option Agreement, as amended. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Anadys Pharmaceuticals, Inc. 2004 Non-Employee Directors&#146; Stock Option
Plan and form Stock Option Agreement, as amended. (1)</TD>
</TR>


<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Anadys Pharmaceuticals, Inc. 2004
Employee Stock Purchase Plan and related form Offering Document, as amended. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.4
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Anadys Pharmaceuticals, Inc. 2002 Equity Incentive Plan and form Stock
Option Agreement, as amended. (1)</TD>
</TR>


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<TR valign="top">
    <TD width="1%" nowrap align="right">(1)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Registrant&#146;s Registration Statement
on Form S-1, as amended (File No.&nbsp;333-110528), originally filed with
the Commission on November&nbsp;14, 2003, and incorporated herein by
reference.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">





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<DIV align="left"><A NAME="001"></A></DIV>

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California on
November&nbsp;19, 2004.


<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top">&nbsp;</TD>
    <TD colspan="3"><B>ANADYS PHARMACEUTICALS, INC.</B><BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000">/s/ Elizabeth E. Reed, Esq.
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2">Elizabeth E. Reed, Esq.&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2">Senior Director, Legal Affairs and Secretary&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>

<P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>




<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>KNOW ALL PERSONS BY THESE PRESENTS</B>, that each person whose signature
appears below hereby constitutes and appoints Kleanthis G. Xanthopoulos, Ph.D.
and Elizabeth E. Reed, Esq., and each of them, his true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution,
for him and in his name, place and stead, in any and all capacities, to sign
any and all amendments (including post-effective amendments) and supplements to
this Registration Statement and any subsequent Registration Statement to be
filed by Anadys Pharmaceuticals, Inc. pursuant to Rule 462(b) under the
Securities Act of 1933, and to file the same, with all exhibits thereto, and
other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorneys-in-fact and agents, and each of them,
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, or any of them, or their
or his or her substitutes or substitute, may lawfully do or cause to be done by
virtue hereof.


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

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    <TD width="40%">&nbsp;</TD>
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    <TD width="30%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="20%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Signature</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Title</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Date</B><HR size="1" noshade></TD>
</TR>


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<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Kleanthis G. Xanthopoulos, Ph.D.<BR>
<HR size="1" noshade>
Kleanthis G. Xanthopoulos, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Chief Executive
Officer, President
and Director
<I>(Principal Executive
Officer)</I>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">November 19, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Michael J. Kamdar<BR>
<I><HR size="1" noshade></I>
Michael J. Kamdar</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
<I>(Principal Financial
Officer and
Principal Accounting
Officer)</I>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">November 19, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Jason Fisherman, M.D.<BR>
<HR size="1" noshade>
Jason Fisherman, M.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Chairman of the Board
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">November 19, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Charles Cohen, Ph.D.<BR>
<HR size="1" noshade>
Charles Cohen, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">November 19, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Marios Fotiadis<BR>
<HR size="1" noshade>
Marios Fotiadis</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">November 19, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Argeris N. Karabelas, Ph.D.<BR>
<HR size="1" noshade>
Argeris N. Karabelas, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">November 19, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">Stelios Papadopoulos, Ph.D.<BR>
<HR size="1" noshade>
Stelios Papadopoulos, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">November 19, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top"><BR>
<HR size="1" noshade>
George A. Scangos, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">November __, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Steven H. Holtzman<BR>
<HR size="1" noshade>
Steven H. Holtzman</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">November 19, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Douglas E. Williams, Ph.D.<BR>
<HR size="1" noshade>
Douglas E. Williams, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">November 19, 2004</TD>
</TR>


<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="002"></A></DIV>

<P align="center" style="font-size: 10pt"><B>EXHIBIT INDEX</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">

<!-- Begin Table Head --><TR valign="bottom">
    <TD width="8%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="87%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Number</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Description</B><HR size="1" noshade></TD>
</TR>


<!-- End Table Head -->

<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Restated Certificate of Incorporation of the Registrant, as amended. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Bylaws of the Registrant, as amended. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Certificate for the Registrant&#146;s Common Stock. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Cooley Godward LLP</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Opinion of Cooley Godward LLP. Reference is made to Exhibit&nbsp;5.1.</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney is contained on the signature pages.</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Anadys Pharmaceuticals, Inc. 2004 Equity Incentive Plan and form Stock
Option Agreement, as amended. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Anadys Pharmaceuticals, Inc. 2004 Non-Employee Directors&#146; Stock Option
Plan and form Stock Option Agreement, as amended. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Anadys Pharmaceuticals, Inc. 2004 Employee Stock Purchase Plan and related
form Offering Document, as amended. (1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.4
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Anadys Pharmaceuticals, Inc. 2002 Equity Incentive Plan and form Stock
Option Agreement, as amended. (1)</TD>
</TR>


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</TABLE>
</DIV>




<P>

<HR size="1" width="18%" align="left" noshade>


<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="1%" nowrap align="right">(1)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Registrant&#146;s Registration
Statement on Form S-1, as amended (File No.&nbsp;333-110528), originally
filed with the Commission on November&nbsp;14, 2003, and incorporated
herein by reference.</TD>
</TR>

</TABLE>




<P align="center" style="font-size: 10pt">&nbsp;
</DIV>


</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "a03492sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 28735}]
{"company-data": {"conformed-name": "ANADYS PHARMACEUTICALS INC", "cik": "0001128495", "assigned-sic": "2834", "irs-number": "223193172"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-120647", "film-number": "041158774"}, "business-address": {"street1": "3115 MERRYFIELD ROW", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "8585303600"}, "mail-address": {"street1": "3115 MERRYFIELD ROW", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}}
Anadys Pharmaceuticals, Inc.
Table of Contents
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Anadys Pharmaceuticals, Inc.
(Exact Name of Registrant as Specified in Its Charter)
Delaware
(State or Other Jurisdiction of
22-3193172
Incorporation or Organization)
(I.R.S. Employer Identification No.)
3115 Merryfield Row
San Diego, California
92121
(Address of Principal Executive Offices)
(Zip Code)
Anadys Pharmaceuticals, Inc.
2004 Equity Incentive Plan
2004 Non-Employee Directors' Stock Option Plan
2004 Employee Stock Purchase Plan
(Full title of the plan)
Elizabeth E. Reed, Esq.
Senior Director, Legal Affairs and Secretary
Anadys Pharmaceuticals, Inc.
3115 Merryfield Row
San Diego, California 92121
(Name and Address of Agent for Service)
(858) 530-3600
(Telephone Number, Including Area Code, of Agent for Service)
Copy to:
Thomas A. Coll, Esq.
Steven M. Przesmicki, Esq.
Cooley Godward LLP
4401 Eastgate Mall
San Diego, California 92121-9109
(858) 550-6000
CALCULATION OF REGISTRATION FEE
Proposed
Title of Each Class
Maximum
Proposed Maximum
of Securities to
Amount to be
Offering
Aggregate
Amount of
be Registered
Registered (1)
Price per Share (2)
Offering Price (2)
Registration Fee
Common Stock issuable
under the 2004 Equity
Incentive Plan (par value
$0.001 per share)
779,333 shares
$
6.67
$
5,198,151.11
$
658.61
Common Stock issuable
under the 2004
Non-Employee Directors'
Stock Option Plan (par
value $0.001 per share)
111,333 shares
$
6.67
$
742,591.11
$
94.09
Common Stock issuable
under the 2004 Employee
Stock Purchase Plan (par
value $0.001 per share)
334,000 shares
$
6.67
$
2,227,780.00
$
282.26
Total
1,224,666 shares
N/A
$
8,168,522.22
$
1,034.96
(1)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "1933 Act"), this
Registration Statement also registers any additional shares of the Registrant's common stock, par
value $0.001 per share (the "Common Stock"), as may become issuable under any of the plans as a result
of any stock split, stock dividend, recapitalization or similar event.
(2)
This estimate is made pursuant to Rule 457(h) of the 1933 Act solely for purposes of calculating the
registration fee. The price per share and aggregate offering price are based upon the average of the
high and low prices of Registrant's Common Stock on
November 16, 2004, as reported on the Nasdaq
National Market.
TABLE OF CONTENTS
EXHIBITS
SIGNATURES
EXHIBIT INDEX
EXHIBIT 5.1
EXHIBIT 23.1
Table of Contents
INCORPORATION BY REFERENCE OF CONTENTS
OF REGISTRATION STATEMENT ON FORM S-8 NO. 333-113954
This Registration Statement is being filed for the purpose of increasing
the number of securities of the same class as other securities for which a
Registration Statement of the Registrant on Form S-8 relating to the same
employee benefit plans is effective. The Registrant previously registered
shares of its Common Stock for issuance under the 2004 Equity Incentive Plan,
2004 Non-Employee Directors' Stock Option Plan, 2004 Employee Stock Purchase
Plan, and 2002 Equity Incentive Plan under a Registration Statement on Form
S-8, filed with the Securities and Exchange Commission (the "SEC") on March 26,
2004 (File No. 333-113954). Pursuant to General Instruction E on Form S-8,
this Registration Statement incorporates by reference the contents of the
Registration Statement referenced above, except as otherwise set forth herein.
EXHIBITS
Exhibit
Number
Description
4.1
Restated Certificate of Incorporation of the Registrant, as amended. (1)
4.2
Bylaws of the Registrant, as amended. (1)
4.3
Specimen Certificate for the Registrant's Common Stock. (1)
5.1
Opinion of Cooley Godward LLP
23.1
Consent of Ernst & Young LLP
23.2
Consent of Cooley Godward LLP. Reference is made to Exhibit 5.1.
24.1
Power of Attorney is contained on the signature page.
99.1
Anadys Pharmaceuticals, Inc. 2004 Equity Incentive Plan and form Stock
Option Agreement, as amended. (1)
99.2
Anadys Pharmaceuticals, Inc. 2004 Non-Employee Directors' Stock Option
Plan and form Stock Option Agreement, as amended. (1)
99.3
Anadys Pharmaceuticals, Inc. 2004
Employee Stock Purchase Plan and related form Offering Document, as amended. (1)
99.4
Anadys Pharmaceuticals, Inc. 2002 Equity Incentive Plan and form Stock
Option Agreement, as amended. (1)
(1)
Filed as an exhibit to the Registrant's Registration Statement
on Form S-1, as amended (File No. 333-110528), originally filed with
the Commission on November 14, 2003, and incorporated herein by
reference.
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California on
November 19, 2004.
ANADYS PHARMACEUTICALS, INC.
By:
/s/ Elizabeth E. Reed, Esq.
Elizabeth E. Reed, Esq.
Senior Director, Legal Affairs and Secretary
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS
, that each person whose signature
appears below hereby constitutes and appoints Kleanthis G. Xanthopoulos, Ph.D.
and Elizabeth E. Reed, Esq., and each of them, his true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution,
for him and in his name, place and stead, in any and all capacities, to sign
any and all amendments (including post-effective amendments) and supplements to
this Registration Statement and any subsequent Registration Statement to be
filed by Anadys Pharmaceuticals, Inc. pursuant to Rule 462(b) under the
Securities Act of 1933, and to file the same, with all exhibits thereto, and
other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorneys-in-fact and agents, and each of them,
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, or any of them, or their
or his or her substitutes or substitute, may lawfully do or cause to be done by
virtue hereof.
Table of Contents
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
Signature
Title
Date
/s/ Kleanthis G. Xanthopoulos, Ph.D.
Kleanthis G. Xanthopoulos, Ph.D.
Chief Executive
Officer, President
and Director
(Principal Executive
Officer)
November 19, 2004
/s/ Michael J. Kamdar
Michael J. Kamdar
(Principal Financial
Officer and
Principal Accounting
Officer)
November 19, 2004
/s/ Jason Fisherman, M.D.
Jason Fisherman, M.D.
Chairman of the Board
November 19, 2004
/s/ Charles Cohen, Ph.D.
Charles Cohen, Ph.D.
Director
November 19, 2004
/s/ Marios Fotiadis
Marios Fotiadis
Director
November 19, 2004
/s/ Argeris N. Karabelas, Ph.D.
Argeris N. Karabelas, Ph.D.
Director
November 19, 2004
Stelios Papadopoulos, Ph.D.
Stelios Papadopoulos, Ph.D.
Director
November 19, 2004
George A. Scangos, Ph.D.
Director
November __, 2004
/s/ Steven H. Holtzman
Steven H. Holtzman
Director
November 19, 2004
/s/ Douglas E. Williams, Ph.D.
Douglas E. Williams, Ph.D.
Director
November 19, 2004
Table of Contents
EXHIBIT INDEX
Exhibit
Number
Description
4.1
Restated Certificate of Incorporation of the Registrant, as amended. (1)
4.2
Bylaws of the Registrant, as amended. (1)
4.3
Specimen Certificate for the Registrant's Common Stock. (1)
5.1
Opinion of Cooley Godward LLP
23.1
Consent of Ernst & Young LLP
23.2
Consent of Opinion of Cooley Godward LLP. Reference is made to Exhibit 5.1.
24.1
Power of Attorney is contained on the signature pages.
99.1
Anadys Pharmaceuticals, Inc. 2004 Equity Incentive Plan and form Stock
Option Agreement, as amended. (1)
99.2
Anadys Pharmaceuticals, Inc. 2004 Non-Employee Directors' Stock Option
Plan and form Stock Option Agreement, as amended. (1)
99.3
Anadys Pharmaceuticals, Inc. 2004 Employee Stock Purchase Plan and related
form Offering Document, as amended. (1)
99.4
Anadys Pharmaceuticals, Inc. 2002 Equity Incentive Plan and form Stock
Option Agreement, as amended. (1)
(1)
Filed as an exhibit to the Registrant's Registration
Statement on Form S-1, as amended (File No. 333-110528), originally
filed with the Commission on November 14, 2003, and incorporated
herein by reference.