<PAGE>   1
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                          BIOSHIELD TECHNOLOGIES, INC.
             (Exact name of registrant as specified in its charter)

            Georgia                                     58-2181628
(State or other jurisdiction of            (I.R.S. Employer Identification No.)
 incorporation or organization)

                           4405 International Blvd.
                                   Suite B-109
                               Norcross, GA 30093

         BioShield Technologies, Inc. 1996 Directors' Stock Option Plan
                            (Full Title of the Plan)

   Timothy C. Moses, 4405 International Blvd., Suite B-109, Norcross, GA 30093
                     (Name and address of agent for service)

                          Copies of Communications to:
                                Timothy C. Moses
                            4405 International Blvd.
                                   Suite B-109
                               Norcross, GA 30093
                                 (770) 925-3432

                         CALCULATION OF REGISTRATION FEE

                        1996 Directors' Stock Option Plan



<TABLE>
<CAPTION>
    Title of
Securities to be      Amount to be         Offering Price           Aggregate             Amount of
   Registered          Registered             Per Share           Offering Price       Registration Fee
 Common Stock
<S>                 <C>                    <C>                    <C>                  <C>
 (no par value)     1,000,000 Shares (1)       $33.00               33,000,000             $8,712.00
</TABLE>


     (1) Represents 1,000,000 shares of Common Stock, authorized for issuance
under the BioShield Technologies, Inc. (the "Company") 1996 Directors' Stock
Option Plan (the "Stock Option Plan"). This Registration Statement also covers
such indeterminable additional number of shares as may be issuable under the
Stock Option Plan by reason of adjustments in the number of shares covered
thereby as described in the Prospectus.

     (2) The price of shares of Common Stock is estimated in accordance with
Rule 457(c), solely for purposes of calculating the registration fee by
reference as the average of the high and low sales prices of the Common Stock on
the Nasdaq SmallCap Stock Market on March 29, 2000, which was $33.00 per share.

<PAGE>   2





Item 6.  Indemnification of Directors and Officers

         The Company's Bylaws provide for the Company to indemnify each director
and officer of the Company against liabilities imposed upon him (including
reasonable amounts paid in settlement) and expenses incurred by him in
connection with any claim made against him or any action, suit or proceeding to
which he may be a party by reason of his being or having been a director or
officer of the Company. The Company has also entered into Indemnification
Agreements with each officer and director pursuant to which the Company will, in
general, indemnify such persons to the maximum extent permitted by the Company's
Bylaws and the laws of the State of Georgia against any expenses (including
attorneys' fees), judgments, fines and amounts paid in settlement incurred in
connection with any actual or threatened action or proceeding to which such
director or officer is made or threatened to be made a party by reason of the
fact that such person is or was a director or officer of the Company. The
foregoing provisions may reduce the likelihood of derivative litigation against
directors and may discourage or deter shareholders or management from suing
directors for breaches of their duty of care, even though such an action, if
successful, might otherwise benefit the Company and its shareholders.

         Insofar as indemnification of liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers, or persons controlling the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been informed that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Act and is
therefore unenforceable. In the event that a claim for indemnification against
such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer, or controlling person of the registrant in the
successful defense of any action, suit, or proceeding) is asserted by such
director, officer, or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

Item 7.  Exemption from Registration Claimed

         Not applicable.

Item 8.  Exhibits

         Reference is made to the Exhibit Index.

Item 9.  Undertakings

         The undersigned registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this registration statement:




<PAGE>   3






         (i)      To include any prospectus required by Section 10(a)(3) of the
Securities Act of 1933;

         (ii)     To reflect in the prospectus any facts or events arising after
the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate,
represents a fundamental change in the information set forth in the registration
statement;

         (iii)    To include any material information with respect to the plan
of distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement; provided,
however, that paragraphs (1)(i) and (1) (ii) do not apply if the registration
statement is on Form S-3, Form S-8, or Form F-3, and the information required to
be included in a post-effective amendment by those paragraphs is contained in
periodic reports filed by the registrant pursuant to Section 13 or Section 15
(d) of Securities Exchange Act of 1934 that are incorporated by reference in the
registration statement.

         (2)      That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (3)      To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the
termination of the offering.

         The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to section 15(d) of the
Securities Exchange Act of 1934) that is incorporated by reference in the
registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 (the "Act") may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions otherwise, the
registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore, unenforceable. In the event a claim for indemnification
against such liabilities (other than the payment by the registrant of expenses
incurred or paid by a director, officer or by the registrant or expenses
incurred or paid by a director, officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]




<PAGE>   4





                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the Company
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Norcross, State of Georgia, on the 30th day of March,
2000.

                                   Bioshield Technologies, Inc.

                                   By /s/ Timothy C. Moses
                                   -----------------------

                                   Timothy C. Moses, President and
                                   Chief Executive Officer






                          BIOSHIELD TECHNOLOGIES, INC.


                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Timothy C. Moses and Jacques Elfersy, and
each of them, his or her true and lawful attorney-in-fact and agent, with full
power of substitution and resubstitution, for him or her and in his or her name,
place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) to this Registration Statement and to file
the same, with all exhibits thereto, and other documents in connection
therewith, with the Securities and Exchange Commission and any other regulatory
authority, granting unto said attorney-in-fact and agent, full power and
authority to do and perform each and every act and thing required and necessary
to be done in and about the premises, as fully to all intents and purposes as he
or she might or could do in person, hereby ratifying and confirming all that
said attorney-in-fact and agent, or his or her substitute, may lawfully do or
cause to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below on March 30, 2000, by the following
persons in the capacities indicated.
<PAGE>   5


<TABLE>
<CAPTION>
SIGNATURE                       TITLE                                             DATE
---------                       -----                                             ----
<S>                             <C>                                               <C>

/s/ Timothy C. Moses            President; Chief Executive Officer;               March 30, 2000
-------------------             Director (Principal Executive Officer)
Timothy C. Moses


/s/ Jacques Elfersy             Chairman of the Board; Vice President of          March 30, 2000
------------------------        Operations and Director of Regulatory
Jacques Elfersy                 Affairs


/s/ Scott Parliament            Chief Financial Officer (Principal                March 30, 2000
------------------------        Financial and Accounting Officer)
Scott Parliament


/s/ Carl T. Garner              Director                                          March 30, 2000
------------------------
Carl T. Garner


/s/ Michel Azran                Director                                          March 30, 2000
------------------------
Michel Azran
</TABLE>







<PAGE>   6





                                  EXHIBIT INDEX

         The following exhibits are filed as a part of the Registration
Statement:


Exhibit 4         BioShield Technologies, Inc. 1996 Directors Stock Option Plan

Exhibit 5         Opinion of Sims Moss Kline & Davis LLP

Exhibit 23.1      Consent of Grant Thornton LLP

Exhibit 23.2      Consent of Sims Moss Kline & Davis LLP (included in Exhibit 5)

Exhibit 24        Power of Attorney (included on signature page herein)
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{"company-data": {"conformed-name": "BIOSHIELD TECHNOLOGIES INC", "cik": "0001059623", "assigned-sic": "2842", "irs-number": "582181628", "state-of-incorporation": "GA", "fiscal-year-end": "0630"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-33606", "film-number": "587333"}, "business-address": {"street1": "4405 INTERNATIONAL BOULEVARD", "street2": "SUITE B109", "city": "NORCROSS", "state": "GA", "zip": "30083", "phone": "7709253432"}, "mail-address": {"street1": "4405 INTERNATIONAL BLVD", "street2": "SUITE B-109", "city": "NORCROSS", "state": "GA", "zip": "30093"}}
1
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                          BIOSHIELD TECHNOLOGIES, INC.
             (Exact name of registrant as specified in its charter)

            Georgia                                     58-2181628
(State or other jurisdiction of            (I.R.S. Employer Identification No.)
 incorporation or organization)

                           4405 International Blvd.
                                   Suite B-109
                               Norcross, GA 30093

         BioShield Technologies, Inc. 1996 Directors' Stock Option Plan
                            (Full Title of the Plan)

   Timothy C. Moses, 4405 International Blvd., Suite B-109, Norcross, GA 30093
                     (Name and address of agent for service)

                          Copies of Communications to:
                                Timothy C. Moses
                            4405 International Blvd.
                                   Suite B-109
                               Norcross, GA 30093
                                 (770) 925-3432

                         CALCULATION OF REGISTRATION FEE

                        1996 Directors' Stock Option Plan
Title of
Securities to be      Amount to be         Offering Price           Aggregate             Amount of
   Registered          Registered             Per Share           Offering Price       Registration Fee
 Common Stock
(no par value)     1,000,000 Shares (1)       $33.00               33,000,000             $8,712.00
(1) Represents 1,000,000 shares of Common Stock, authorized for issuance
under the BioShield Technologies, Inc. (the "Company") 1996 Directors' Stock
Option Plan (the "Stock Option Plan"). This Registration Statement also covers
such indeterminable additional number of shares as may be issuable under the
Stock Option Plan by reason of adjustments in the number of shares covered
thereby as described in the Prospectus.

     (2) The price of shares of Common Stock is estimated in accordance with
Rule 457(c), solely for purposes of calculating the registration fee by
reference as the average of the high and low sales prices of the Common Stock on
the Nasdaq SmallCap Stock Market on March 29, 2000, which was $33.00 per share.
2

Item 6.  Indemnification of Directors and Officers

         The Company's Bylaws provide for the Company to indemnify each director
and officer of the Company against liabilities imposed upon him (including
reasonable amounts paid in settlement) and expenses incurred by him in
connection with any claim made against him or any action, suit or proceeding to
which he may be a party by reason of his being or having been a director or
officer of the Company. The Company has also entered into Indemnification
Agreements with each officer and director pursuant to which the Company will, in
general, indemnify such persons to the maximum extent permitted by the Company's
Bylaws and the laws of the State of Georgia against any expenses (including
attorneys' fees), judgments, fines and amounts paid in settlement incurred in
connection with any actual or threatened action or proceeding to which such
director or officer is made or threatened to be made a party by reason of the
fact that such person is or was a director or officer of the Company. The
foregoing provisions may reduce the likelihood of derivative litigation against
directors and may discourage or deter shareholders or management from suing
directors for breaches of their duty of care, even though such an action, if
successful, might otherwise benefit the Company and its shareholders.

         Insofar as indemnification of liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers, or persons controlling the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been informed that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Act and is
therefore unenforceable. In the event that a claim for indemnification against
such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer, or controlling person of the registrant in the
successful defense of any action, suit, or proceeding) is asserted by such
director, officer, or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

Item 7.  Exemption from Registration Claimed

         Not applicable.

Item 8.  Exhibits

         Reference is made to the Exhibit Index.

Item 9.  Undertakings

         The undersigned registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this registration statement:
3

         (i)      To include any prospectus required by Section 10(a)(3) of the
Securities Act of 1933;

         (ii)     To reflect in the prospectus any facts or events arising after
the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate,
represents a fundamental change in the information set forth in the registration
statement;

         (iii)    To include any material information with respect to the plan
of distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement; provided,
however, that paragraphs (1)(i) and (1) (ii) do not apply if the registration
statement is on Form S-3, Form S-8, or Form F-3, and the information required to
be included in a post-effective amendment by those paragraphs is contained in
periodic reports filed by the registrant pursuant to Section 13 or Section 15
(d) of Securities Exchange Act of 1934 that are incorporated by reference in the
registration statement.

         (2)      That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (3)      To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the
termination of the offering.

         The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to section 15(d) of the
Securities Exchange Act of 1934) that is incorporated by reference in the
registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 (the "Act") may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions otherwise, the
registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore, unenforceable. In the event a claim for indemnification
against such liabilities (other than the payment by the registrant of expenses
incurred or paid by a director, officer or by the registrant or expenses
incurred or paid by a director, officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]
4

                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the Company
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Norcross, State of Georgia, on the 30th day of March,
2000.

                                   Bioshield Technologies, Inc.

                                   By /s/ Timothy C. Moses
                                   -----------------------

                                   Timothy C. Moses, President and
                                   Chief Executive Officer

                          BIOSHIELD TECHNOLOGIES, INC.

                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Timothy C. Moses and Jacques Elfersy, and
each of them, his or her true and lawful attorney-in-fact and agent, with full
power of substitution and resubstitution, for him or her and in his or her name,
place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) to this Registration Statement and to file
the same, with all exhibits thereto, and other documents in connection
therewith, with the Securities and Exchange Commission and any other regulatory
authority, granting unto said attorney-in-fact and agent, full power and
authority to do and perform each and every act and thing required and necessary
to be done in and about the premises, as fully to all intents and purposes as he
or she might or could do in person, hereby ratifying and confirming all that
said attorney-in-fact and agent, or his or her substitute, may lawfully do or
cause to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below on March 30, 2000, by the following
persons in the capacities indicated.
5
SIGNATURE                       TITLE                                             DATE
---------                       -----                                             ----
/s/ Timothy C. Moses            President; Chief Executive Officer;               March 30, 2000
-------------------             Director (Principal Executive Officer)
Timothy C. Moses

/s/ Jacques Elfersy             Chairman of the Board; Vice President of          March 30, 2000
------------------------        Operations and Director of Regulatory
Jacques Elfersy                 Affairs

/s/ Scott Parliament            Chief Financial Officer (Principal                March 30, 2000
------------------------        Financial and Accounting Officer)
Scott Parliament

/s/ Carl T. Garner              Director                                          March 30, 2000
------------------------
Carl T. Garner

/s/ Michel Azran                Director                                          March 30, 2000
------------------------
Michel Azran
6

                                  EXHIBIT INDEX

         The following exhibits are filed as a part of the Registration
Statement:

Exhibit 4         BioShield Technologies, Inc. 1996 Directors Stock Option Plan

Exhibit 5         Opinion of Sims Moss Kline & Davis LLP

Exhibit 23.1      Consent of Grant Thornton LLP

Exhibit 23.2      Consent of Sims Moss Kline & Davis LLP (included in Exhibit 5)

Exhibit 24        Power of Attorney (included on signature page herein)