<PAGE>   1
       AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 10, 2001
                                                    REGISTRATION NO. 333-______
--------------------------------------------------------------------------------

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                           --------------------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                           --------------------------

                               PRACTICEWORKS, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

              DELAWARE                                   52-2259090
   (State or other jurisdiction of                    (I.R.S. Employer
   incorporation or organization)                   Identification Number)

                          1765 THE EXCHANGE, SUITE 200
                             ATLANTA, GEORGIA 30339
                                 (770) 850-5006
                  (Address of registrant's principal executive
                    offices, including zip code and telephone
                          number, including area code)

                           ---------------------------

                   PRACTICEWORKS, INC. 2000 STOCK OPTION PLAN
                            (Full title of the Plan)


          James A. Cochran                           Copy to:
      Chief Financial Officer                   John J. Kelley III
        PracticeWorks, Inc.                       King & Spalding
    1765 The Exchange, Suite 200            191 Peachtree Street, N.E.
       Atlanta, Georgia 30339                 Atlanta, Georgia 30303
           (770) 850-5006                         (404) 572-4600

 (Name, address, including zip code, and telephone number, including area code,
                              of agent for service)
                           ---------------------------

<TABLE>
<CAPTION>
                                              CALCULATION OF REGISTRATION FEE
==================================================================================================================================
                                                                  Proposed
                                              Amount to be        Maximum          Proposed Maximum
 Title of Securities to be Registered          Registered         Offering        Aggregate Offering    Amount of Registration Fee
                                                                 Price Per              Price
                                                                 Share(1)
----------------------------------------------------------------------------------------------------------------------------------
<S>                                           <C>                <C>              <C>                   <C>
Common Stock, $.01 par value per share          8,000,000          $6.28             $50,240,000                   $12,560
==================================================================================================================================
</TABLE>

-----------------
(1)      Estimated solely for the purpose of calculating the registration fee
         pursuant to Rule 457(h) of the Securities Act of 1933, as amended, on
         the basis of the high and low sales prices of Common Stock of
         PracticeWorks, Inc. on the American Stock Exchange on May 9, 2001.



<PAGE>   2


                                     PART I


              INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS

         The documents containing the information specified in Part I will be
sent or given to employees and/or directors of PracticeWorks, Inc.
("PracticeWorks" or the "Registrant") as specified by Rule 428(b)(1) of the
Securities Act of 1933, as amended (the "Securities Act"). In accordance with
the instructions to Part I of Form S-8, such documents will not be filed with
the Securities and Exchange Commission (the "Commission") either as part of this
Registration Statement or as prospectuses or prospectus supplements pursuant to
Rule 424 of the Securities Act. These documents and the documents incorporated
by reference pursuant to Item 3 of Part II of this Registration Statement, taken
together, constitute the prospectus as required by Section 10(a) of the
Securities Act.


                                     PART II


               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


ITEM 3.           INCORPORATION OF DOCUMENTS BY REFERENCE.

         The following documents have been previously filed by PracticeWorks
with the Commission and are incorporated herein by reference into this
Registration Statement as of their respective dates:

         (a)      PracticeWorks Annual Report on Form 10-K, as filed with the
Commission on April 2, 2001, which contains audited financial statements for
PracticeWorks for the fiscal year ended December 31, 2000;

         (b)      PracticeWorks Current Report on Form 8-K, filed with the
Commission on March 22, 2001 (as amended on April 26, 2001); and

         (c)      PracticeWorks Registration Statement on Form 8-A/A (with
respect to the description of PracticeWorks' Common Stock), as filed with the
Commission on February 20, 2001, including any amendment or report filed for the
purpose of updating such description.

         In addition, all documents filed by PracticeWorks pursuant to Sections
13(a), 13(c), 14, and 15(d) of the Securities Exchange Act of 1934, as amended
(the "Exchange Act") subsequent to the date of the Registration Statement and
prior to the filing of a post-effective amendment to this Registration Statement
indicating that all securities offered hereunder have been sold or deregistering
all securities then remaining unsold, shall be deemed to be incorporated herein
by reference into this Registration Statement and shall be deemed to be a part
hereof from the date of filing of such documents.

         Any statement contained in any document incorporated or deemed to be
incorporated by reference into this Registration Statement shall be deemed to be
modified or superseded for purposes thereof to the extent that a statement
contained therein or in any other subsequently filed document that is also
incorporated or deemed to be incorporated therein by reference modifies or
supersedes such statement. Any such statement so modified or superseded shall
now be deemed to constitute a part of this Registration Statement.

ITEM 4.  DESCRIPTION OF SECURITIES.

         Not applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

         Not applicable.



                                       2
<PAGE>   3

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.


         Section 145 of the Delaware General Corporation Law permits a Delaware
corporation to indemnify officers, directors, employees and agents for actions
taken in good faith and in a manner they reasonably believed to be in, or not
opposed to, the best interests of the corporation, and with respect to any
criminal action, which they had no reasonable cause to believe was unlawful. The
Delaware General Corporation Law provides that a corporation may pay expenses
(including attorneys' fees) incurred by an officer or director in defending any
civil, criminal, administrative or investigative action, and must reimburse a
successful defendant for expenses, including attorney's fees, actually and
reasonably incurred, and permits a corporation to purchase and maintain
liability insurance for its directors and officers. The Delaware General
Corporation Law provides that indemnification may not be made for any claim,
issue or matter as to which a person has been adjudged by a court of competent
jurisdiction to be liable to the corporation, unless and only to the extent a
court determines that the person is entitled to indemnity for such expenses as
the court deems proper.

         The Registrant's bylaws allow, and in some cases require, the
indemnification of directors and officers under certain circumstances and grant
our directors and officers a right to indemnification to the full extent
permitted by law for all expenses relating to civil, criminal, administrative or
investigative procedures to which they are a party (1) by reason of the fact
that they are or were the Registrant's directors or officers or (2) by reason of
the fact that, while they are or were the Registrant's directors or officers,
they are or were serving at the Registrant's request as a director, officer or
employee of another enterprise. The Registrant's bylaws further provide that an
advancement for any such expenses shall only be made upon delivery to the
Registrant by the indemnitee of an undertaking to repay all amounts so advanced
if it is ultimately determined that such indemnitee is not entitled to be
indemnified by the Registrant.

         The Registrant has entered into indemnification agreements with its
directors and officers. These agreements require the Registrant to indemnify
these directors and officers with respect to their activities as its directors
or officers or when serving at its request as a director, officer or trustee of
another corporation, joint venture, trust or other enterprise against expenses,
including attorneys' fees, judgments, fines and amounts paid in settlement
actually and reasonably incurred by them in any threatened, pending or completed
suit or proceeding to which they are, or are threatened to be made, parties as a
result of their service to the Registrant. The Registrant agrees to indemnify
each indemnitee for any one or a combination of the following, whichever is most
advantageous to the indemnitee: (1) the benefits provided by the Registrant's
certificate of incorporation and bylaws in effect on the date of the
indemnification agreement; (2) the benefits provided by the Registrant's
certificate of incorporation and bylaws at the time expenses are incurred by the
indemnitee; (3) the benefits allowable under Delaware law in effect on the date
of the indemnification agreement; (4) the benefits allowable under the law of
the jurisdiction under which the Registrant exists at the time expenses are
incurred by the indemnitee; (5) the benefits available under liability insurance
obtained by the Registrant; and (6) such other benefits as may be otherwise
available to indemnitee under our existing practices. Under the indemnification
agreements, each indemnitee will continue to be indemnified even after ceasing
to occupy a position as the Registrant's officer, director, employee or agent
with respect to suits or proceedings arising out of acts or omissions during his
or her service to the Registrant. Each indemnitee agrees to notify the
Registrant promptly of any proceeding brought or threatened and not to make any
admission or settlement without the Registrant's consent, unless the indemnitee
determines to undertake his or her own defense and waives the benefits of the
indemnification agreement.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

         Not applicable.


                                       3
<PAGE>   4




ITEM 8.           EXHIBITS.

         The following exhibits are filed with or incorporated by reference into
this Registration Statement pursuant to Item 601 of Regulation S-K:


<TABLE>
<CAPTION>
               Exhibit No.                         Description
               -----------                         -----------
               <S>         <C>

                  4.1      Certificate of Incorporation of PracticeWorks, Inc.
                           (incorporated by reference to Exhibit 3.1 to
                           PracticeWorks' Registration Statement on Form S-1,
                           filed with the Commission on January 16, 2001).

                  4.2      Bylaws of PracticeWorks, Inc. (incorporated by
                           reference to Exhibit 3.3 to PracticeWorks'
                           Registration Statement on Form S-1, filed with the
                           Commission on January 16, 2001).

                  4.3      Form of certificate representing PracticeWorks, Inc.
                           common stock (incorporated by reference to Exhibit
                           4.1 to Amendment No. 1 to PracticeWorks' Registration
                           Statement on Form 10, filed with the Commission on
                           November 13, 2000).

                  4.4      Amended and Restated PracticeWorks, Inc. 2000 Stock
                           Plan (incorporated by reference to Exhibit 10.6 to
                           Amendment No. 1 to PracticeWorks' Registration
                           Statement on Form 10, filed with the Commission on
                           November 13, 2000).

                  5.1      Opinion of King & Spalding as to the legality of the
                           securities being registered.

                  23.1     Consent of BDO Seidman, LLP

                  23.2     Consent of King & Spalding (included in Exhibit 5.1)

                  24.1     Powers of Attorney (included on signature page)
</TABLE>


                                       4
<PAGE>   5


ITEM 9.           UNDERTAKINGS.


         (a)      The undersigned Registrant hereby undertakes:

                  (1)      To file, during any period in which offers or sales
         are being made, a post-effective amendment to this Registration
         Statement:

                           (i)     To include any prospectus required by
                                   Section 10(a)(3) of the Securities Act;

                           (ii)    To reflect in the prospectus any facts or
                                   events arising after the effective date of
                                   the Registration Statement (or the most
                                   recent post-effective amendment thereof)
                                   which, individually or in the aggregate,
                                   represent a fundamental change in the
                                   information set forth in the Registration
                                   Statement; and

                           (iii)   To include any material information with
                                   respect to the plan of distribution not
                                   previously disclosed in the Registration
                                   Statement or any material change to such
                                   information in the Registration Statement.

         provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
         apply if the information required to be included in a post-effective
         amendment by those paragraphs is contained in periodic reports filed
         with or furnished to the Commission by the registrant pursuant to
         Section 13 or 15(d) of the Exchange Act that are incorporated by
         reference in the registration statement.

                  (2)      That, for the purpose of determining any liability
         under the Securities Act, each such post-effective amendment shall be
         deemed to be a new registration statement relating to the securities
         offered therein, and the offering of such securities at that time shall
         be deemed to be the initial bona fide offering thereof.

                  (3)      To remove from the registration by means of a
         post-effective amendment any of the securities being registered which
         remain unsold at the termination of the offering.

         (b)      The undersigned Registrant hereby undertakes that, for
purposes of determining any liability under the Securities Act, each filing of
the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit plan's
annual report pursuant to Section 15(d) of the Exchange Act) that is
incorporated by reference in the registration statement shall be deemed to be a
new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (c)      Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Securities Act and will be governed by the final
adjudication of such issue.


                                     EXPERTS

         The financial statements and schedules incorporated by reference in
this Prospectus have been audited by BDO Seidman, LLP, independent certified
public accountants, to the extent and for the periods set forth in their reports
incorporated herein by reference, and are incorporated herein in reliance upon
such report given upon the authority of said firm as experts in auditing and
accounting.


                                       5
<PAGE>   6



                                   SIGNATURES

         Pursuant to the requirements of the Securities Act, the undersigned
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Atlanta, State of Georgia, on this the 10th day of
May, 2001.

                                     PRACTICEWORKS, INC.


                                     By: /s/ James K. Price
                                        ------------------------------------
                                         James K. Price
                                         President and Chief Executive Officer


                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signatures
appears below constitutes and appoints Richard E. Perlman and James A. Cochran,
and each of them, as his true and lawful attorneys-in-fact and agents, with full
power of substitution and resubstitution, for him and in his name, place and
stead, in any and all capacities, to sign a Registration Statement relating to
the registration of shares of common stock on Form S-8 and to sign any and all
amendments (including post effective amendments) to the Registration Statement,
and to file the same, with all exhibits thereto and other documents in
connection therewith, with the Commission, granting unto said attorneys-in-fact
and agents, and each of them, full power and authority to do and perform each
and every act and thing required or necessary to be done in and about the
premises, as fully to all intents and purposes as he might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and
agents, or any of them, or their or his substitute, could lawfully do or cause
to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed below by the following persons in the capacities
indicated on May 10, 2001.

<TABLE>
<CAPTION>
               SIGNATURE                                               TITLE

    <S>                                               <C>
                                                      Chief Executive Officer, President and
    /s/ James K. Price                                Director
    -----------------------------------
    James K. Price
                                                      Chairman of the Board and Director
    /s/ Richard E. Perlman
    -----------------------------------
    Richard E. Perlman
                                                      Senior Vice President, Secretary and
    /s/ James A. Cochran                              Chief Financial Officer (Principal
    -----------------------------------               Financial Officer and Principal
    James A. Cochran                                  Accounting Officer)

                                                      Executive Vice President and Director
    -----------------------------------
    James C. Davis

    /s/ William R. Jellison                           Director
    -----------------------------------
    William R. Jellison

    /s/ William A. Shutzer                            Director
    -----------------------------------
    William A. Shutzer

    /s/ Raymond H. Welsh                              Director
    -----------------------------------
    Raymond H. Welsh
</TABLE>


                                       6
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{"company-data": {"conformed-name": "PRACTICE WORKS INC", "cik": "0001121786", "assigned-sic": "8742"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-60588", "film-number": "1627582"}, "business-address": {"street1": "1765 THE EXCHANGE", "street2": "SUITE 200", "city": "ATLANTA", "state": "GA", "zip": "30339"}, "mail-address": {"street1": "1765 THE EXCHANGE", "street2": "SUITE 500", "city": "ATLANTA", "state": "GA", "zip": "30339"}}
1
       AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 10, 2001
                                                    REGISTRATION NO. 333-______
--------------------------------------------------------------------------------

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                           --------------------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                           --------------------------

                               PRACTICEWORKS, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

              DELAWARE                                   52-2259090
   (State or other jurisdiction of                    (I.R.S. Employer
   incorporation or organization)                   Identification Number)

                          1765 THE EXCHANGE, SUITE 200
                             ATLANTA, GEORGIA 30339
                                 (770) 850-5006
                  (Address of registrant's principal executive
                    offices, including zip code and telephone
                          number, including area code)

                           ---------------------------

                   PRACTICEWORKS, INC. 2000 STOCK OPTION PLAN
                            (Full title of the Plan)

          James A. Cochran                           Copy to:
      Chief Financial Officer                   John J. Kelley III
        PracticeWorks, Inc.                       King & Spalding
    1765 The Exchange, Suite 200            191 Peachtree Street, N.E.
       Atlanta, Georgia 30339                 Atlanta, Georgia 30303
           (770) 850-5006                         (404) 572-4600

 (Name, address, including zip code, and telephone number, including area code,
                              of agent for service)
                           ---------------------------
CALCULATION OF REGISTRATION FEE
==================================================================================================================================
                                                                  Proposed
                                              Amount to be        Maximum          Proposed Maximum
 Title of Securities to be Registered          Registered         Offering        Aggregate Offering    Amount of Registration Fee
                                                                 Price Per              Price
                                                                 Share(1)
----------------------------------------------------------------------------------------------------------------------------------
Common Stock, $.01 par value per share          8,000,000          $6.28             $50,240,000                   $12,560
==================================================================================================================================
-----------------
(1)      Estimated solely for the purpose of calculating the registration fee
         pursuant to Rule 457(h) of the Securities Act of 1933, as amended, on
         the basis of the high and low sales prices of Common Stock of
         PracticeWorks, Inc. on the American Stock Exchange on May 9, 2001.
2

                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS

         The documents containing the information specified in Part I will be
sent or given to employees and/or directors of PracticeWorks, Inc.
("PracticeWorks" or the "Registrant") as specified by Rule 428(b)(1) of the
Securities Act of 1933, as amended (the "Securities Act"). In accordance with
the instructions to Part I of Form S-8, such documents will not be filed with
the Securities and Exchange Commission (the "Commission") either as part of this
Registration Statement or as prospectuses or prospectus supplements pursuant to
Rule 424 of the Securities Act. These documents and the documents incorporated
by reference pursuant to Item 3 of Part II of this Registration Statement, taken
together, constitute the prospectus as required by Section 10(a) of the
Securities Act.

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.           INCORPORATION OF DOCUMENTS BY REFERENCE.

         The following documents have been previously filed by PracticeWorks
with the Commission and are incorporated herein by reference into this
Registration Statement as of their respective dates:

         (a)      PracticeWorks Annual Report on Form 10-K, as filed with the
Commission on April 2, 2001, which contains audited financial statements for
PracticeWorks for the fiscal year ended December 31, 2000;

         (b)      PracticeWorks Current Report on Form 8-K, filed with the
Commission on March 22, 2001 (as amended on April 26, 2001); and

         (c)      PracticeWorks Registration Statement on Form 8-A/A (with
respect to the description of PracticeWorks' Common Stock), as filed with the
Commission on February 20, 2001, including any amendment or report filed for the
purpose of updating such description.

         In addition, all documents filed by PracticeWorks pursuant to Sections
13(a), 13(c), 14, and 15(d) of the Securities Exchange Act of 1934, as amended
(the "Exchange Act") subsequent to the date of the Registration Statement and
prior to the filing of a post-effective amendment to this Registration Statement
indicating that all securities offered hereunder have been sold or deregistering
all securities then remaining unsold, shall be deemed to be incorporated herein
by reference into this Registration Statement and shall be deemed to be a part
hereof from the date of filing of such documents.

         Any statement contained in any document incorporated or deemed to be
incorporated by reference into this Registration Statement shall be deemed to be
modified or superseded for purposes thereof to the extent that a statement
contained therein or in any other subsequently filed document that is also
incorporated or deemed to be incorporated therein by reference modifies or
supersedes such statement. Any such statement so modified or superseded shall
now be deemed to constitute a part of this Registration Statement.

ITEM 4.  DESCRIPTION OF SECURITIES.

         Not applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

         Not applicable.

                                       2
3

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         Section 145 of the Delaware General Corporation Law permits a Delaware
corporation to indemnify officers, directors, employees and agents for actions
taken in good faith and in a manner they reasonably believed to be in, or not
opposed to, the best interests of the corporation, and with respect to any
criminal action, which they had no reasonable cause to believe was unlawful. The
Delaware General Corporation Law provides that a corporation may pay expenses
(including attorneys' fees) incurred by an officer or director in defending any
civil, criminal, administrative or investigative action, and must reimburse a
successful defendant for expenses, including attorney's fees, actually and
reasonably incurred, and permits a corporation to purchase and maintain
liability insurance for its directors and officers. The Delaware General
Corporation Law provides that indemnification may not be made for any claim,
issue or matter as to which a person has been adjudged by a court of competent
jurisdiction to be liable to the corporation, unless and only to the extent a
court determines that the person is entitled to indemnity for such expenses as
the court deems proper.

         The Registrant's bylaws allow, and in some cases require, the
indemnification of directors and officers under certain circumstances and grant
our directors and officers a right to indemnification to the full extent
permitted by law for all expenses relating to civil, criminal, administrative or
investigative procedures to which they are a party (1) by reason of the fact
that they are or were the Registrant's directors or officers or (2) by reason of
the fact that, while they are or were the Registrant's directors or officers,
they are or were serving at the Registrant's request as a director, officer or
employee of another enterprise. The Registrant's bylaws further provide that an
advancement for any such expenses shall only be made upon delivery to the
Registrant by the indemnitee of an undertaking to repay all amounts so advanced
if it is ultimately determined that such indemnitee is not entitled to be
indemnified by the Registrant.

         The Registrant has entered into indemnification agreements with its
directors and officers. These agreements require the Registrant to indemnify
these directors and officers with respect to their activities as its directors
or officers or when serving at its request as a director, officer or trustee of
another corporation, joint venture, trust or other enterprise against expenses,
including attorneys' fees, judgments, fines and amounts paid in settlement
actually and reasonably incurred by them in any threatened, pending or completed
suit or proceeding to which they are, or are threatened to be made, parties as a
result of their service to the Registrant. The Registrant agrees to indemnify
each indemnitee for any one or a combination of the following, whichever is most
advantageous to the indemnitee: (1) the benefits provided by the Registrant's
certificate of incorporation and bylaws in effect on the date of the
indemnification agreement; (2) the benefits provided by the Registrant's
certificate of incorporation and bylaws at the time expenses are incurred by the
indemnitee; (3) the benefits allowable under Delaware law in effect on the date
of the indemnification agreement; (4) the benefits allowable under the law of
the jurisdiction under which the Registrant exists at the time expenses are
incurred by the indemnitee; (5) the benefits available under liability insurance
obtained by the Registrant; and (6) such other benefits as may be otherwise
available to indemnitee under our existing practices. Under the indemnification
agreements, each indemnitee will continue to be indemnified even after ceasing
to occupy a position as the Registrant's officer, director, employee or agent
with respect to suits or proceedings arising out of acts or omissions during his
or her service to the Registrant. Each indemnitee agrees to notify the
Registrant promptly of any proceeding brought or threatened and not to make any
admission or settlement without the Registrant's consent, unless the indemnitee
determines to undertake his or her own defense and waives the benefits of the
indemnification agreement.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

         Not applicable.

                                       3
4

ITEM 8.           EXHIBITS.

         The following exhibits are filed with or incorporated by reference into
this Registration Statement pursuant to Item 601 of Regulation S-K:
Exhibit No.                         Description
               -----------                         -----------
4.1      Certificate of Incorporation of PracticeWorks, Inc.
                           (incorporated by reference to Exhibit 3.1 to
                           PracticeWorks' Registration Statement on Form S-1,
                           filed with the Commission on January 16, 2001).

                  4.2      Bylaws of PracticeWorks, Inc. (incorporated by
                           reference to Exhibit 3.3 to PracticeWorks'
                           Registration Statement on Form S-1, filed with the
                           Commission on January 16, 2001).

                  4.3      Form of certificate representing PracticeWorks, Inc.
                           common stock (incorporated by reference to Exhibit
                           4.1 to Amendment No. 1 to PracticeWorks' Registration
                           Statement on Form 10, filed with the Commission on
                           November 13, 2000).

                  4.4      Amended and Restated PracticeWorks, Inc. 2000 Stock
                           Plan (incorporated by reference to Exhibit 10.6 to
                           Amendment No. 1 to PracticeWorks' Registration
                           Statement on Form 10, filed with the Commission on
                           November 13, 2000).

                  5.1      Opinion of King & Spalding as to the legality of the
                           securities being registered.

                  23.1     Consent of BDO Seidman, LLP

                  23.2     Consent of King & Spalding (included in Exhibit 5.1)

                  24.1     Powers of Attorney (included on signature page)
4
5

ITEM 9.           UNDERTAKINGS.

         (a)      The undersigned Registrant hereby undertakes:

                  (1)      To file, during any period in which offers or sales
         are being made, a post-effective amendment to this Registration
         Statement:

                           (i)     To include any prospectus required by
                                   Section 10(a)(3) of the Securities Act;

                           (ii)    To reflect in the prospectus any facts or
                                   events arising after the effective date of
                                   the Registration Statement (or the most
                                   recent post-effective amendment thereof)
                                   which, individually or in the aggregate,
                                   represent a fundamental change in the
                                   information set forth in the Registration
                                   Statement; and

                           (iii)   To include any material information with
                                   respect to the plan of distribution not
                                   previously disclosed in the Registration
                                   Statement or any material change to such
                                   information in the Registration Statement.

         provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
         apply if the information required to be included in a post-effective
         amendment by those paragraphs is contained in periodic reports filed
         with or furnished to the Commission by the registrant pursuant to
         Section 13 or 15(d) of the Exchange Act that are incorporated by
         reference in the registration statement.

                  (2)      That, for the purpose of determining any liability
         under the Securities Act, each such post-effective amendment shall be
         deemed to be a new registration statement relating to the securities
         offered therein, and the offering of such securities at that time shall
         be deemed to be the initial bona fide offering thereof.

                  (3)      To remove from the registration by means of a
         post-effective amendment any of the securities being registered which
         remain unsold at the termination of the offering.

         (b)      The undersigned Registrant hereby undertakes that, for
purposes of determining any liability under the Securities Act, each filing of
the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit plan's
annual report pursuant to Section 15(d) of the Exchange Act) that is
incorporated by reference in the registration statement shall be deemed to be a
new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (c)      Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Securities Act and will be governed by the final
adjudication of such issue.

                                     EXPERTS

         The financial statements and schedules incorporated by reference in
this Prospectus have been audited by BDO Seidman, LLP, independent certified
public accountants, to the extent and for the periods set forth in their reports
incorporated herein by reference, and are incorporated herein in reliance upon
such report given upon the authority of said firm as experts in auditing and
accounting.

                                       5
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                                   SIGNATURES

         Pursuant to the requirements of the Securities Act, the undersigned
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Atlanta, State of Georgia, on this the 10th day of
May, 2001.

                                     PRACTICEWORKS, INC.

                                     By: /s/ James K. Price
                                        ------------------------------------
                                         James K. Price
                                         President and Chief Executive Officer

                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signatures
appears below constitutes and appoints Richard E. Perlman and James A. Cochran,
and each of them, as his true and lawful attorneys-in-fact and agents, with full
power of substitution and resubstitution, for him and in his name, place and
stead, in any and all capacities, to sign a Registration Statement relating to
the registration of shares of common stock on Form S-8 and to sign any and all
amendments (including post effective amendments) to the Registration Statement,
and to file the same, with all exhibits thereto and other documents in
connection therewith, with the Commission, granting unto said attorneys-in-fact
and agents, and each of them, full power and authority to do and perform each
and every act and thing required or necessary to be done in and about the
premises, as fully to all intents and purposes as he might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and
agents, or any of them, or their or his substitute, could lawfully do or cause
to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed below by the following persons in the capacities
indicated on May 10, 2001.
SIGNATURE                                               TITLE
Chief Executive Officer, President and
    /s/ James K. Price                                Director
    -----------------------------------
    James K. Price
                                                      Chairman of the Board and Director
    /s/ Richard E. Perlman
    -----------------------------------
    Richard E. Perlman
                                                      Senior Vice President, Secretary and
    /s/ James A. Cochran                              Chief Financial Officer (Principal
    -----------------------------------               Financial Officer and Principal
    James A. Cochran                                  Accounting Officer)

                                                      Executive Vice President and Director
    -----------------------------------
    James C. Davis

    /s/ William R. Jellison                           Director
    -----------------------------------
    William R. Jellison

    /s/ William A. Shutzer                            Director
    -----------------------------------
    William A. Shutzer

    /s/ Raymond H. Welsh                              Director
    -----------------------------------
    Raymond H. Welsh
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