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<TITLE>Bioheart Inc.</TITLE>
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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center" style="font-size: 10pt; margin-top: 0pt">As filed with the Securities and Exchange Commission on April&nbsp;18, 2008
</DIV>

<DIV align="right" style="font-size: 10pt; margin-top: 6pt">Registration No.&nbsp;333-
</DIV>


<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>




<DIV align="center" style="font-size: 14pt; margin-top: 6pt"><B>UNITED STATES SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</B>
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>
</DIV>

<DIV align="center" style="font-size: 18pt; margin-top: 6pt"><B>FORM S-8</B>
</DIV>

<DIV align="center" style="font-size: 10pt"><B>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</B></DIV>


<DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>Bioheart, Inc.</B>
</DIV>

<DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>


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    <TD align="center" valign="top"><B>Florida</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>65-0945967</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">(State or other jurisdiction of <BR>
incorporation or organization)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
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    <TD align="center" valign="top"><B>13794 NW 4<SUP style="font-size: 85%; vertical-align: text-top">th</SUP> Street, Suite&nbsp;212<BR>
Sunrise, Florida</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="bottom"><B>33325</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">(Address of Principal Executive Offices)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(Zip Code)</TD>
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</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Officers and Employees Stock Option Plan<BR>
Directors and Consultants Stock Option Plan</B><BR>
(Full title of the plans)
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>William M. Pinon<BR>
President and Chief Executive Officer<BR>
Bioheart, Inc.<BR>
13794 NW 4<SUP style="font-size: 85%; vertical-align: text-top">th</SUP> Street, Suite&nbsp;212<BR>
Sunrise, Florida 33325</B><BR>
(Name and address of agent for service)
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>(954)&nbsp;835-1500</B><BR>
(Telephone number, including area code, of agent for service)
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt">with a copy to:<BR>
<B>David E. Wells, Esq.<BR>
Hunton &#038; Williams LLP<BR>
1111 Brickell Avenue, Suite&nbsp;2500<BR>
Miami, FL 33131<BR>
(305)&nbsp;810-2500</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Indicate by check mark whether the registrant is a large
accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &#147;large accelerated filer,&#148; &#147;accelerated filer&#148; and &#147;smaller reporting company&#148; in Rule 12b-2 of the Exchange Act. (Check one):</DIV>
</DIV>

<DIV align="center" style="font-size: 6pt">&nbsp;
</DIV>


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    <TD align="left" valign="top" nowrap>Large accelerated filer&nbsp;<FONT face="Wingdings">&#111;</FONT>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top" nowrap>Accelerated filer&nbsp;<FONT face="Wingdings">&#111;</FONT>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top" nowrap>Non-accelerated
filer&nbsp;<FONT face="Wingdings">&#254;</FONT>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top" nowrap>Smaller reporting company&nbsp;<FONT face="Wingdings">&#111;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;
</TD>

    <TD nowrap colspan="3" align="center" valign="top">(Do not check if a smaller reporting company)</TD>

    <TD align="right" valign="top">&nbsp;</TD>
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</DIV>






<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>CALCULATION OF REGISTRATION FEE</B></U>
</DIV>

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    <TD width="7%">&nbsp;</TD>
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    <TD width="1%">&nbsp;</TD>
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    <TD nowrap align="left" colspan="19" style="border-bottom: 3px double #000000">&nbsp;</TD>
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    <TD>&nbsp;</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Amount To Be</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Proposed Maximum</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Proposed Maximum</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
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<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD nowrap align="center">Title of Each Class of Securities</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Registered</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Offering Price Per</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Aggregate Offering</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Amount of</TD>
    <TD width="1%">&nbsp;</TD>
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<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD nowrap align="center">To Be Registered</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Share</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Price</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Registration Fee</TD>
    <TD width="1%">&nbsp;</TD>
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                    <TD valign="top" style="border-top: 2px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">Common Stock, par value $0.001 per share
</DIV></TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>
    <TD nowrap align="right" valign="top" style="border-top: 2px solid #000000">&nbsp;</TD>
    <TD align="right" valign="top" style="border-top: 2px solid #000000">895,689</TD>
    <TD nowrap valign="top" style="border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>
    <TD align="center" valign="top" style="border-top: 2px solid #000000">$4.12<SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP>
</TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>
    <TD align="center" valign="top" style="border-top: 2px solid #000000">$3,690,239<SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP>
</TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>
    <TD nowrap align="right" valign="top" style="border-top: 2px solid #000000">$</TD>
    <TD align="right" valign="top" style="border-top: 2px solid #000000">145.03</TD>
    <TD nowrap valign="top" style="border-top: 2px solid #000000">&nbsp;</TD>
    <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 1px" valign="bottom">
    <TD nowrap align="left" colspan="19" style="border-top: 3px double #000000">&nbsp;</TD>
</TR>

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<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the
&#147;Securities Act&#148;), this Registration Statement shall also cover an indeterminate number of
additional shares of common stock which become issuable under the above-named plans by reason
of any stock dividend, stock split, recapitalization, or other similar transaction effected
without the receipt of consideration which results in an increase in the number of our
outstanding shares of common stock.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Estimated solely for the purpose of calculating the registration fee. In accordance with
Rule 457(h) promulgated under the Securities Act, the price shown is based upon the average of
the high and low prices reported for the Common Stock on the NASDAQ Global Market on April&nbsp;14,
2008.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>








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<A name="tocpage"></A>
</DIV>
<!-- link1 "PART I<BR> INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS" -->

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART I<BR>
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The information specified in Item&nbsp;1 and Item&nbsp;2 of Part&nbsp;I of this Registration Statement on
Form S-8 (the &#147;Registration Statement&#148;) is omitted from this filing in accordance with the
provisions of Rule&nbsp;428 promulgated pursuant to the Securities Act and the introductory note to Part
I of Form S-8. The documents containing the information specified in Part&nbsp;I will be delivered to
the participants in the Bioheart Officers and Employees Stock Option Plan (the &#147;Officers Plan&#148;) and
the Bioheart Directors and Consultants Stock Option Plan (the &#147;Directors Plan,&#148; and collectively
with the Officers Plan, the &#147;Plans&#148;) pursuant to Rule&nbsp;428(b)(1) of the Securities Act.
</DIV>
<!-- link1 "PART II<BR> INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II<BR>
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
</DIV>

<!-- link2 "Item&nbsp;3. <U>Incorporation of Documents by Reference</U>." -->

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;3. </B><U><B>Incorporation of Documents by Reference</B></U><B>.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents, which have previously been filed by Bioheart, Inc. (the &#147;Registrant&#148;)
with the Securities and Exchange Commission (the &#147;Commission&#148;), are hereby incorporated into this
Registration Statement:
</DIV>

<DIV style="margin-top: 6pt">
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<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Registrant&#146;s Annual Report on Form 10-K for the fiscal year ended December&nbsp;31, 2007,
filed on March&nbsp;27, 2008;</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Registrant&#146;s Prospectus dated February&nbsp;19, 2008, as filed on February&nbsp;21, 2008
pursuant to Rule 424(b) of the Securities Act, contained in Registrant&#146;s Registration
Statement on Form S-1 (File No.&nbsp;333-140672), as amended (the &#147;S-1 Registration
Statement&#148;); and</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The section entitled &#147;Description of Registrant&#146;s Securities to be Registered&#148;
contained in Registrant&#146;s Registration Statement on Form 8-A, filed pursuant to Section
12(b) of the Securities Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;) on
October&nbsp;2, 2007, and incorporating by reference the information contained in the S-1
Registration Statement.</TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each document filed by the Registrant after the date hereof pursuant to Sections&nbsp;13(a), 13(c),
14 or 15(d) of the Exchange Act and prior to the filing of a post-effective amendment which
indicates that all securities offered hereby have been sold or which deregisters all securities
remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement
and shall be part hereof from the date of filing of such document. Any statement contained in a
document, all or a portion of which is incorporated by reference herein, shall be deemed to be
modified or superseded for purposes of this Registration Statement to the extent that a statement
contained or incorporated by reference herein modifies or supersedes such statement. Any statement
so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a
part of this Registration Statement.
</DIV>
<!-- link2 "Item&nbsp;4. <U>Description of Securities</U>." -->

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;4. </B><U><B>Description of Securities</B></U><B>.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
</DIV>
<!-- link2 "Item&nbsp;5. <U>Interests of Named Experts and Counsel</U>." -->

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;5. </B><U><B>Interests of Named Experts and Counsel</B></U><B>.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link2 "Item&nbsp;6. <U>Indemnification of Directors and Officers</U>." -->

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;6. </B><U><B>Indemnification of Directors and Officers</B></U><B>.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We are incorporated under the laws of the State of Florida. Our articles of incorporation
require us to indemnify and limit the liability of directors to the fullest extent permitted by the
Florida Business Corporation Act (the &#147;FBCA&#148;), as it currently exists or as it may be amended in
the future.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the FBCA, a Florida corporation may indemnify any person who may be a party to any
third party proceeding by reason of the fact that such person is or was a director, officer,
employee or agent of the corporation, or is or was serving at the request of the corporation as a
director, officer, employee, or agent of another entity, against liability incurred in connection
with such proceeding (including any appeal thereof) if he or she acted in good faith and in a
manner he or she reasonably believed to be in, or not opposed to, the best interests of the
corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to
believe his or her conduct was unlawful.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In addition, in accordance with the FBCA, a Florida corporation is permitted to indemnify any
person who may be a party to a derivative action if such person acted in any of the capacities set
forth in the preceding paragraph, against expenses and amounts paid in settlement not exceeding, in
the judgment of the board of directors, the estimated expenses of litigating the proceeding to
conclusion, actually and reasonably incurred in connection with the defense or settlement of such
proceeding (including appeals), provided that the person acted under the standards set forth in the
preceding paragraph. However, no indemnification shall be made for any claim, issue, or matter for
which such person is found to be liable unless, and only to the extent that, the court determines
that, despite the adjudication of liability, but in view of all the circumstances of the case, such
person is fairly and reasonably entitled to indemnification for such expenses which the court deems
proper.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any indemnification made under the above provisions, unless pursuant to a court&#146;s
determination, may be made only after a determination that the person to be indemnified has met the
standard of conduct described above. This determination is to be made by a majority vote of a
quorum consisting of the disinterested directors of the board of directors, by duly selected
independent legal counsel, or by a majority vote of the disinterested shareholders. The board of
directors also may designate a special committee of disinterested directors to make this
determination. Notwithstanding the foregoing, a Florida corporation must indemnify any director,
officer, employee or agent of a corporation who has been successful in the defense of any
proceeding referred to above.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Generally, pursuant to the FBCA, a director of a Florida corporation is not personally liable
for monetary damages to our company or any other person for any statement, vote, decision, or
failure to act, regarding corporate management or policy, unless: (a)&nbsp;the director breached or
failed to perform his duties as a director; and (b)&nbsp;the director&#146;s breach of, or failure to
perform, those duties constitutes (i)&nbsp;a violation of criminal law, unless the director had
reasonable cause to believe his conduct was lawful or had no reasonable cause to believe his
conduct was unlawful, (ii)&nbsp;a transaction from which the director derived an improper personal
benefit, either directly or indirectly, (iii)&nbsp;an approval of an unlawful distribution, (iv)&nbsp;with
respect to a proceeding by or in the right of the company to procure a judgment in its favor or by
or in the right of a shareholder, conscious disregard for the best interest of the company, or
willful misconduct, or (v)&nbsp;with respect to a proceeding by or in the right of someone other than
the company or a shareholder, recklessness or an act or omission which was committed in bad faith
or with malicious purpose or in a manner exhibiting wanton and willful disregard of human rights,
safety, or property. The term &#147;recklessness,&#148; as used above, means the action, or omission to act,
in conscious disregard of a risk: (a)&nbsp;known, or so obvious that it should have been known, to the
directors; and (b)&nbsp;known to the director, or so obvious that it should have been known, to be so
great as to make it highly probable that harm would follow from such action or omission.
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Furthermore, under the FBCA, a Florida corporation is authorized to make any other further
indemnification or advancement of expenses of any of its directors, officers, employees or agents
under
any bylaw, agreement, vote of shareholders or disinterested directors, or otherwise, both for
actions taken in an official capacity and for actions taken in other capacities while holding such
office. However, a corporation cannot indemnify or advance expenses if a judgment or other final
adjudication establishes that the actions of the director, officer, employee, or agent were
material to the adjudicated cause of action and the director, officer, employee, or agent (a)
violated criminal law, unless the director, officer, employee, or agent had reasonable cause to
believe his or her conduct was unlawful, (b)&nbsp;derived an improper personal benefit from a
transaction, (c)&nbsp;was or is a director in a circumstance where the liability for unlawful
distributions applies, or (d)&nbsp;engaged in willful misconduct or conscious disregard for the best
interests of the corporation in a proceeding by or in right of the corporation to procure a
judgment in its favor.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;At present, there is no pending litigation or proceeding involving any of our directors or
executive officers as to which indemnification is required or permitted and we are not aware of any
threatened litigation or proceeding that may result in a claim for indemnification.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We maintain a liability insurance policy, pursuant to which our directors and officers may be
insured against liability they incur for serving in their capacities as directors and officers of
our company, including liabilities arising under the Securities Act or otherwise.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We entered into an underwriting agreement in connection with our initial public offering which
provides that the underwriters are obligated, under some circumstances, to indemnify our directors,
officers and controlling persons against specified liabilities, including liabilities under the
Securities Act. Reference is made to the form of Underwriting Agreement filed as Exhibit&nbsp;1.1 to
the Registrant&#146;s Registration Statement on Form S-1 (File No.&nbsp;333-140672).
</DIV>
<!-- link2 "Item&nbsp;7. <U>Exemption from Registration Claimed</U>." -->

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;7. </B><U><B>Exemption from Registration Claimed</B></U><B>.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
</DIV>
<!-- link2 "Item&nbsp;8. <U>Exhibits</U>." -->

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;8. </B><U><B>Exhibits</B></U><B>.</B>
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="88%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" colspan="3"><B>Number</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" colspan="3" style="border-bottom: 1px solid #000000"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Exhibit</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">4.1</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Amended and Restated Articles of Incorporation of Bioheart, Inc., as amended (1)</DIV></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">4.2</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Amended and Restated Bylaws of Bioheart, Inc. (2)</DIV></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">4.3</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Form of Common Stock Certificate (1)</DIV></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">4.4</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">1999 Officers and Employees Stock Option Plan (2)</DIV></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">4.5</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">1999 Directors and Consultants Stock Option Plan (2)</DIV></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">5.1</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Opinion of Hunton &#038; Williams, LLP*</DIV></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">23.1</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Grant Thornton LLP*</DIV></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">23.2</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Hunton &#038; Williams LLP (included as part of Exhibit&nbsp;5.1)*</DIV></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">24.1</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Power of attorney (included on signature page to this Registration Statement)*</DIV></TD>
</TR>
<!-- End Table Body -->
<TR><TD colspan="9"><FONT size="2">&nbsp;<A HREF="g12896exv5w1.htm">EX-5.1 Opinion of Hunton & Williams</A></FONT></TD></TR>
<TR><TD colspan="9"><FONT size="2">&nbsp;<A HREF="g12896exv23w1.htm">EX-23.1 Consent of Grant Thornton LLP</A></FONT></TD></TR>
</TABLE>
</DIV>

<DIV align="left">
<!-- /TOC -->
</DIV>


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">*</TD>
    <TD>&nbsp;</TD>
    <TD>Filed herewith</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(1)</TD>
    <TD>&nbsp;</TD>
    <TD>Incorporated by reference to Amendment No.&nbsp;5 to the Company&#146;s Registration Statement on Form
S-1 (File No.&nbsp;333-140672), filed with the Commission on October&nbsp;1, 2007.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(2)</TD>
    <TD>&nbsp;</TD>
    <TD>Incorporated by reference to the Company&#146;s Registration Statement on Form S-1 (File No.
333-140672) filed with the Commission n on February&nbsp;13, 2007.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt"><!-- Folio -->3<!-- /Folio -->
</DIV>

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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">





<!-- link2 "Item&nbsp;9. <U>Undertakings</U>." -->

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;9. </B><U><B>Undertakings</B></U><B>.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The undersigned Registrant hereby undertakes:
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement:
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act;
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective
date of the Registration Statement (or the most recent post-effective amendment
thereof) which, individually or in the aggregate, represent a fundamental change in
the information set forth in the Registration Statement. Notwithstanding the
foregoing, any increase or decrease in volume of securities offered (if the total
dollar value of securities offered would not exceed that which was registered) and any
deviation from the low or high end of the estimated maximum offering range may be
reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b)
of the Securities Act of 1933 if, in the aggregate, the changes in volume and price
represent no more than a 20&nbsp;percent change in the maximum aggregate offering price set
forth in the &#147;Calculation of Registration Fee&#148; table in the effective registration
statement;
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of
distribution not previously disclosed in the Registration Statement or any material
change to such information in the Registration Statement;
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%"><I>provided, however</I>, that:
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="7%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">A.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Paragraphs (a)(1)(i) and (a)(1)(ii) of this section do not apply if
the registration statement is on Form S-8, and the information required to be
included in a post-effective amendment by those paragraphs is contained in
reports filed with or furnished to the Commission by the registrant pursuant to
section 13 or section 15(d) of the Securities Exchange Act of 1934 that are
incorporated by reference in the registration statement; and</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="7%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">B.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) of this section do
not apply if the registration statement is on Form S-3 or Form F-3 and the
information required to be included in a post-effective amendment by those
paragraphs is contained in reports filed with or furnished to the Commission by
the registrant pursuant to section 13 or section 15(d) of the Securities Exchange
Act of 1934 that are incorporated by reference in the registration statement, or
is contained in a form of prospectus filed pursuant to Rule 424(b) that is part
of the registration statement.</TD>
</TR>

</TABLE>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) That, for the purpose of determining any liability under the Securities Act of
1933, each such post-effective amendment shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities at that time
shall be deemed to be the initial <I>bona fide </I>offering thereof.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) To remove from registration by means of a post-effective amendment any of the
securities being registered which remain unsold at the termination of the offering.
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->4<!-- /Folio -->
</DIV>

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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;The Registrant hereby undertakes that, for purposes of determining any liability under the
Securities Act of 1933, each filing of the Registrant&#146;s annual report pursuant to Section 13(a) or
15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee
benefit plan&#146;s annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that
is incorporated by reference in the Registration Statement shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that
time shall be deemed to be the initial <I>bona fide </I>offering thereof.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
permitted to directors, officers and controlling persons of the Registrant pursuant to the
foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public policy as expressed in
the Act and is, therefore, unenforceable. In the event that a claim for indemnification against
such liabilities (other than the payment by the Registrant of expenses incurred or paid by a
director, officer or controlling person of the Registrant in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling person in connection with
the securities being registered, the Registrant will, unless in the opinion of its counsel the
matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the
question whether such indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->5<!-- /Folio -->
</DIV>

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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link1 "SIGNATURES" -->

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Sunrise, State of Florida, on April&nbsp;15, 2008.
</DIV>

<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">Bioheart, Inc.<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ William M. Pinon
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top">Name:&nbsp;&nbsp;</TD>
    <TD align="left">William M. Pinon&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD valign="top">Title:&nbsp;&nbsp;</TD>
    <TD align="left">President and Chief Executive Officer&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>POWER OF ATTORNEY</B>
</DIV>



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below hereby constitutes and appoints William M. Pinon and
William H. Kline, and each of them, his true and lawful attorneys-in-fact and agents, with full
power of substitution and revocation, to sign on his behalf, individually and in each capacity
stated below, all amendments and post-effective amendments to this Registration Statement on Form
S-8 and to file the same, with all exhibits thereto and any other documents in connection
therewith, with the Securities and Exchange Commission under the Securities Act of 1933, as
amended, granting unto such attorneys-in-fact and agents full power and authority to do and perform
each and every act and thing requisite and necessary to be done in and about the premises, as fully
to all intents and purposes as each such person might or could do in person, hereby ratifying and
confirming each act that said attorneys-in-fact and agents may lawfully do or cause to be done by
virtue thereof.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities indicated below on the dates set forth
below.
</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="30%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="30%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" nowrap valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ <FONT style="font-variant: SMALL-CAPS">William M. Pinon</FONT>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
William M. Pinon</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
President, Chief Executive Officer
and Director<BR>

<I>(principal executive officer)</I>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April 15, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ <FONT style="font-variant: SMALL-CAPS">William H. Kline</FONT>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
William H. Kline</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Chief Financial Officer<BR>
<I>(principal financial and
accounting officer)</I>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April 15, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ <FONT style="font-variant: SMALL-CAPS">Howard J. Leonhardt</FONT>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Howard J. Leonhardt</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Chairman of the Board and Chief<BR>

Technology Officer
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April 18, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ <FONT style="font-variant: SMALL-CAPS">David Gury</FONT>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
David Gury</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April 18, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ <FONT style="font-variant: SMALL-CAPS">William P. Murphy, Jr., M.D.</FONT>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
William P. Murphy, Jr., M.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April 8, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ <FONT style="font-variant: SMALL-CAPS">Richard T. Spencer III</FONT>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Richard T. Spencer III</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April 3, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ <FONT style="font-variant: SMALL-CAPS">Linda Tufts</FONT>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Linda Tufts</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April 8, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ <FONT style="font-variant: SMALL-CAPS">Mike Tomas</FONT>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Mike Tomas</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April 8, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ <FONT style="font-variant: SMALL-CAPS">Peggy Farley</FONT>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Peggy Farley</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April 8, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ <FONT style="font-variant: SMALL-CAPS">Bruce Carson</FONT>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Bruce Carson</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April 7, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Sam Ahn, M.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">April <U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>, 2008</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->6<!-- /Folio -->
</DIV>

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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXHIBIT INDEX</B>
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="3%">&nbsp;</TD>
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    <TD nowrap align="center" colspan="3" style="border-bottom: 1px solid #000000"><B>Number</B></TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Opinion of Hunton &#038; Williams, LLP</DIV></TD>
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    <TD align="right" valign="top">23.1</TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Grant Thornton LLP</DIV></TD>
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    <TD align="right" valign="top">23.2</TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Consent of Hunton &#038; Williams LLP (included as part of Exhibit&nbsp;5.1)</DIV></TD>
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    <TD align="right" valign="top">24.1</TD>
    <TD nowrap valign="top">&nbsp;</TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Power of attorney (included on signature page to this Registration Statement)</DIV></TD>
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Bioheart Inc.
Table of Contents
As filed with the Securities and Exchange Commission on April 18, 2008
Registration No. 333-
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
Bioheart, Inc.
(Exact name of registrant as specified in its charter)
Florida
65-0945967
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer Identification No.)
13794 NW 4
th
Street, Suite 212
Sunrise, Florida
33325
(Address of Principal Executive Offices)
(Zip Code)
Officers and Employees Stock Option Plan
Directors and Consultants Stock Option Plan
(Full title of the plans)
William M. Pinon
President and Chief Executive Officer
Bioheart, Inc.
13794 NW 4
th
Street, Suite 212
Sunrise, Florida 33325
(Name and address of agent for service)
(954) 835-1500
(Telephone number, including area code, of agent for service)
with a copy to:
David E. Wells, Esq.
Hunton & Williams LLP
1111 Brickell Avenue, Suite 2500
Miami, FL 33131
(305) 810-2500
Indicate by check mark whether the registrant is a large
accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act. (Check one):
Large accelerated filer
o
Accelerated filer
o
Non-accelerated
filer
þ
Smaller reporting company
o
(Do not check if a smaller reporting company)
CALCULATION OF REGISTRATION FEE
Amount To Be
Proposed Maximum
Proposed Maximum
Title of Each Class of Securities
Registered
Offering Price Per
Aggregate Offering
Amount of
To Be Registered
(1)
Share
Price
Registration Fee
Common Stock, par value $0.001 per share
895,689
$4.12
(2)
$3,690,239
(2)
$
145.03
(1)
Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the
"Securities Act"), this Registration Statement shall also cover an indeterminate number of
additional shares of common stock which become issuable under the above-named plans by reason
of any stock dividend, stock split, recapitalization, or other similar transaction effected
without the receipt of consideration which results in an increase in the number of our
outstanding shares of common stock.
(2)
Estimated solely for the purpose of calculating the registration fee. In accordance with
Rule 457(h) promulgated under the Securities Act, the price shown is based upon the average of
the high and low prices reported for the Common Stock on the NASDAQ Global Market on April 14,
2008.
Table of Contents
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
The information specified in Item 1 and Item 2 of Part I of this Registration Statement on
Form S-8 (the "Registration Statement") is omitted from this filing in accordance with the
provisions of Rule 428 promulgated pursuant to the Securities Act and the introductory note to Part
I of Form S-8. The documents containing the information specified in Part I will be delivered to
the participants in the Bioheart Officers and Employees Stock Option Plan (the "Officers Plan") and
the Bioheart Directors and Consultants Stock Option Plan (the "Directors Plan," and collectively
with the Officers Plan, the "Plans") pursuant to Rule 428(b)(1) of the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference
.
The following documents, which have previously been filed by Bioheart, Inc. (the "Registrant")
with the Securities and Exchange Commission (the "Commission"), are hereby incorporated into this
Registration Statement:
•
Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2007,
filed on March 27, 2008;
•
Registrant's Prospectus dated February 19, 2008, as filed on February 21, 2008
pursuant to Rule 424(b) of the Securities Act, contained in Registrant's Registration
Statement on Form S-1 (File No. 333-140672), as amended (the "S-1 Registration
Statement"); and
•
The section entitled "Description of Registrant's Securities to be Registered"
contained in Registrant's Registration Statement on Form 8-A, filed pursuant to Section
12(b) of the Securities Exchange Act of 1934, as amended (the "Exchange Act") on
October 2, 2007, and incorporating by reference the information contained in the S-1
Registration Statement.
Each document filed by the Registrant after the date hereof pursuant to Sections 13(a), 13(c),
14 or 15(d) of the Exchange Act and prior to the filing of a post-effective amendment which
indicates that all securities offered hereby have been sold or which deregisters all securities
remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement
and shall be part hereof from the date of filing of such document. Any statement contained in a
document, all or a portion of which is incorporated by reference herein, shall be deemed to be
modified or superseded for purposes of this Registration Statement to the extent that a statement
contained or incorporated by reference herein modifies or supersedes such statement. Any statement
so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a
part of this Registration Statement.
Item 4.
Description of Securities
.
Not applicable.
Item 5.
Interests of Named Experts and Counsel
.
Not applicable.
1
Table of Contents
Item 6.
Indemnification of Directors and Officers
.
We are incorporated under the laws of the State of Florida. Our articles of incorporation
require us to indemnify and limit the liability of directors to the fullest extent permitted by the
Florida Business Corporation Act (the "FBCA"), as it currently exists or as it may be amended in
the future.
Pursuant to the FBCA, a Florida corporation may indemnify any person who may be a party to any
third party proceeding by reason of the fact that such person is or was a director, officer,
employee or agent of the corporation, or is or was serving at the request of the corporation as a
director, officer, employee, or agent of another entity, against liability incurred in connection
with such proceeding (including any appeal thereof) if he or she acted in good faith and in a
manner he or she reasonably believed to be in, or not opposed to, the best interests of the
corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to
believe his or her conduct was unlawful.
In addition, in accordance with the FBCA, a Florida corporation is permitted to indemnify any
person who may be a party to a derivative action if such person acted in any of the capacities set
forth in the preceding paragraph, against expenses and amounts paid in settlement not exceeding, in
the judgment of the board of directors, the estimated expenses of litigating the proceeding to
conclusion, actually and reasonably incurred in connection with the defense or settlement of such
proceeding (including appeals), provided that the person acted under the standards set forth in the
preceding paragraph. However, no indemnification shall be made for any claim, issue, or matter for
which such person is found to be liable unless, and only to the extent that, the court determines
that, despite the adjudication of liability, but in view of all the circumstances of the case, such
person is fairly and reasonably entitled to indemnification for such expenses which the court deems
proper.
Any indemnification made under the above provisions, unless pursuant to a court's
determination, may be made only after a determination that the person to be indemnified has met the
standard of conduct described above. This determination is to be made by a majority vote of a
quorum consisting of the disinterested directors of the board of directors, by duly selected
independent legal counsel, or by a majority vote of the disinterested shareholders. The board of
directors also may designate a special committee of disinterested directors to make this
determination. Notwithstanding the foregoing, a Florida corporation must indemnify any director,
officer, employee or agent of a corporation who has been successful in the defense of any
proceeding referred to above.
Generally, pursuant to the FBCA, a director of a Florida corporation is not personally liable
for monetary damages to our company or any other person for any statement, vote, decision, or
failure to act, regarding corporate management or policy, unless: (a) the director breached or
failed to perform his duties as a director; and (b) the director's breach of, or failure to
perform, those duties constitutes (i) a violation of criminal law, unless the director had
reasonable cause to believe his conduct was lawful or had no reasonable cause to believe his
conduct was unlawful, (ii) a transaction from which the director derived an improper personal
benefit, either directly or indirectly, (iii) an approval of an unlawful distribution, (iv) with
respect to a proceeding by or in the right of the company to procure a judgment in its favor or by
or in the right of a shareholder, conscious disregard for the best interest of the company, or
willful misconduct, or (v) with respect to a proceeding by or in the right of someone other than
the company or a shareholder, recklessness or an act or omission which was committed in bad faith
or with malicious purpose or in a manner exhibiting wanton and willful disregard of human rights,
safety, or property. The term "recklessness," as used above, means the action, or omission to act,
in conscious disregard of a risk: (a) known, or so obvious that it should have been known, to the
directors; and (b) known to the director, or so obvious that it should have been known, to be so
great as to make it highly probable that harm would follow from such action or omission.
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Table of Contents
Furthermore, under the FBCA, a Florida corporation is authorized to make any other further
indemnification or advancement of expenses of any of its directors, officers, employees or agents
under
any bylaw, agreement, vote of shareholders or disinterested directors, or otherwise, both for
actions taken in an official capacity and for actions taken in other capacities while holding such
office. However, a corporation cannot indemnify or advance expenses if a judgment or other final
adjudication establishes that the actions of the director, officer, employee, or agent were
material to the adjudicated cause of action and the director, officer, employee, or agent (a)
violated criminal law, unless the director, officer, employee, or agent had reasonable cause to
believe his or her conduct was unlawful, (b) derived an improper personal benefit from a
transaction, (c) was or is a director in a circumstance where the liability for unlawful
distributions applies, or (d) engaged in willful misconduct or conscious disregard for the best
interests of the corporation in a proceeding by or in right of the corporation to procure a
judgment in its favor.
At present, there is no pending litigation or proceeding involving any of our directors or
executive officers as to which indemnification is required or permitted and we are not aware of any
threatened litigation or proceeding that may result in a claim for indemnification.
We maintain a liability insurance policy, pursuant to which our directors and officers may be
insured against liability they incur for serving in their capacities as directors and officers of
our company, including liabilities arising under the Securities Act or otherwise.
We entered into an underwriting agreement in connection with our initial public offering which
provides that the underwriters are obligated, under some circumstances, to indemnify our directors,
officers and controlling persons against specified liabilities, including liabilities under the
Securities Act. Reference is made to the form of Underwriting Agreement filed as Exhibit 1.1 to
the Registrant's Registration Statement on Form S-1 (File No. 333-140672).
Item 7.
Exemption from Registration Claimed
.
Not applicable.
Item 8.
Exhibits
.
Number
Exhibit
Exhibit
4.1
Amended and Restated Articles of Incorporation of Bioheart, Inc., as amended (1)
4.2
Amended and Restated Bylaws of Bioheart, Inc. (2)
4.3
Form of Common Stock Certificate (1)
4.4
1999 Officers and Employees Stock Option Plan (2)
4.5
1999 Directors and Consultants Stock Option Plan (2)
5.1
Opinion of Hunton & Williams, LLP*
23.1
Consent of Grant Thornton LLP*
23.2
Consent of Hunton & Williams LLP (included as part of Exhibit 5.1)*
24.1
Power of attorney (included on signature page to this Registration Statement)*
EX-5.1 Opinion of Hunton & Williams
EX-23.1 Consent of Grant Thornton LLP
*
Filed herewith
(1)
Incorporated by reference to Amendment No. 5 to the Company's Registration Statement on Form
S-1 (File No. 333-140672), filed with the Commission on October 1, 2007.
(2)
Incorporated by reference to the Company's Registration Statement on Form S-1 (File No.
333-140672) filed with the Commission n on February 13, 2007.
3
Table of Contents
Item 9.
Undertakings
.
(a) The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement:
(i) To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii) To reflect in the prospectus any facts or events arising after the effective
date of the Registration Statement (or the most recent post-effective amendment
thereof) which, individually or in the aggregate, represent a fundamental change in
the information set forth in the Registration Statement. Notwithstanding the
foregoing, any increase or decrease in volume of securities offered (if the total
dollar value of securities offered would not exceed that which was registered) and any
deviation from the low or high end of the estimated maximum offering range may be
reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b)
of the Securities Act of 1933 if, in the aggregate, the changes in volume and price
represent no more than a 20 percent change in the maximum aggregate offering price set
forth in the "Calculation of Registration Fee" table in the effective registration
statement;
(iii) To include any material information with respect to the plan of
distribution not previously disclosed in the Registration Statement or any material
change to such information in the Registration Statement;
provided, however
, that:
A.
Paragraphs (a)(1)(i) and (a)(1)(ii) of this section do not apply if
the registration statement is on Form S-8, and the information required to be
included in a post-effective amendment by those paragraphs is contained in
reports filed with or furnished to the Commission by the registrant pursuant to
section 13 or section 15(d) of the Securities Exchange Act of 1934 that are
incorporated by reference in the registration statement; and
B.
Paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) of this section do
not apply if the registration statement is on Form S-3 or Form F-3 and the
information required to be included in a post-effective amendment by those
paragraphs is contained in reports filed with or furnished to the Commission by
the registrant pursuant to section 13 or section 15(d) of the Securities Exchange
Act of 1934 that are incorporated by reference in the registration statement, or
is contained in a form of prospectus filed pursuant to Rule 424(b) that is part
of the registration statement.
(2) That, for the purpose of determining any liability under the Securities Act of
1933, each such post-effective amendment shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities at that time
shall be deemed to be the initial
bona fide
offering thereof.
(3) To remove from registration by means of a post-effective amendment any of the
securities being registered which remain unsold at the termination of the offering.
4
Table of Contents
(b) The Registrant hereby undertakes that, for purposes of determining any liability under the
Securities Act of 1933, each filing of the Registrant's annual report pursuant to Section 13(a) or
15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee
benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that
is incorporated by reference in the Registration Statement shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that
time shall be deemed to be the initial
bona fide
offering thereof.
(c) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
permitted to directors, officers and controlling persons of the Registrant pursuant to the
foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public policy as expressed in
the Act and is, therefore, unenforceable. In the event that a claim for indemnification against
such liabilities (other than the payment by the Registrant of expenses incurred or paid by a
director, officer or controlling person of the Registrant in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling person in connection with
the securities being registered, the Registrant will, unless in the opinion of its counsel the
matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the
question whether such indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.
5
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Sunrise, State of Florida, on April 15, 2008.
Bioheart, Inc.
By:
/s/ William M. Pinon
Name:
William M. Pinon
Title:
President and Chief Executive Officer
POWER OF ATTORNEY
Each person whose signature appears below hereby constitutes and appoints William M. Pinon and
William H. Kline, and each of them, his true and lawful attorneys-in-fact and agents, with full
power of substitution and revocation, to sign on his behalf, individually and in each capacity
stated below, all amendments and post-effective amendments to this Registration Statement on Form
S-8 and to file the same, with all exhibits thereto and any other documents in connection
therewith, with the Securities and Exchange Commission under the Securities Act of 1933, as
amended, granting unto such attorneys-in-fact and agents full power and authority to do and perform
each and every act and thing requisite and necessary to be done in and about the premises, as fully
to all intents and purposes as each such person might or could do in person, hereby ratifying and
confirming each act that said attorneys-in-fact and agents may lawfully do or cause to be done by
virtue thereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities indicated below on the dates set forth
below.
Signature
Title
Date
/s/
William M. Pinon
William M. Pinon
President, Chief Executive Officer
and Director
(principal executive officer)
April 15, 2008
/s/
William H. Kline
William H. Kline
Chief Financial Officer
(principal financial and
accounting officer)
April 15, 2008
/s/
Howard J. Leonhardt
Howard J. Leonhardt
Chairman of the Board and Chief
Technology Officer
April 18, 2008
/s/
David Gury
David Gury
Director
April 18, 2008
/s/
William P. Murphy, Jr., M.D.
William P. Murphy, Jr., M.D.
Director
April 8, 2008
/s/
Richard T. Spencer III
Richard T. Spencer III
Director
April 3, 2008
/s/
Linda Tufts
Linda Tufts
Director
April 8, 2008
/s/
Mike Tomas
Mike Tomas
Director
April 8, 2008
/s/
Peggy Farley
Peggy Farley
Director
April 8, 2008
/s/
Bruce Carson
Bruce Carson
Director
April 7, 2008
Sam Ahn, M.D.
Director
April
, 2008
6
Table of Contents
EXHIBIT INDEX
Exhibit
Number
Exhibit
5.1
Opinion of Hunton & Williams, LLP
23.1
Consent of Grant Thornton LLP
23.2
Consent of Hunton & Williams LLP (included as part of Exhibit 5.1)
24.1
Power of attorney (included on signature page to this Registration Statement)
7