<HTML>
<HEAD>
<TITLE>
</TITLE>
</HEAD>
<BODY>




   <PAGE>
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<FONT STYLE="font-size:10pt">As filed with the Securities and Exchange
		Commission on October 1, 2007</FONT>
	 </P>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="98%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="78%" VALIGN="top" STYLE="padding:8.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:right;margin-top:8pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="21%" VALIGN="top" STYLE="padding:8.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:right;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Registration No.
				  333-&nbsp;&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:14PT">UNITED STATES</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:14PT">SECURITIES AND EXCHANGE
		COMMISSION</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<FONT STYLE="font-size:10pt">Washington, D.C. 20549</FONT>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:10PT">FORM S-8</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:10PT">REGISTRATION STATEMENT UNDER THE
		SECURITIES ACT OF 1933</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:16PT">VION PHARMACEUTICALS, INC.</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<FONT STYLE="font-size:10pt">(Exact name of registrant as specified in
		its charter)</FONT>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
	 <DIV ALIGN="center">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="32%" VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P ALIGN="center">
				  <B><FONT STYLE="font-size:10pt">Delaware</FONT></B>
				</P>
			 </TD>
			 <TD WIDTH="33%" VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt;line-height:86.4%;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="33%" VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P ALIGN="right" STYLE="text-align:center;">
				  <B><FONT STYLE="font-size:10pt">13-3671221</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P ALIGN="center">
				  <FONT STYLE="font-size:10pt">(State or other jurisdiction of
				  <BR>incorporation or organization)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt;line-height:86.4%;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P ALIGN="center" STYLE="text-align:center;">
				  <FONT STYLE="font-size:10pt">(I.R.S. Employer Identification
				  No.)</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD COLSPAN="3" VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:right;margin-top:0pt;margin-bottom:6.0pt;line-height:86.4%;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P ALIGN="center">
				  <B><FONT STYLE="font-size:10pt">4 Science Park<BR>
				  New Haven, Connecticut</FONT></B>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt;line-height:86.4%;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom" STYLE="padding:0in .05in 0in .05in;">
				<P ALIGN="center" STYLE="text-align:center;">
				  <B><FONT STYLE="font-size:10pt">06511</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P ALIGN="center">
				  <FONT STYLE="font-size:9pt">(Address of principal executive
				  offices)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0pt;margin-bottom:0pt;line-height:86.4%;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:0in .05in 0in .05in;">
				<P ALIGN="center" STYLE="text-align:center;">
				  <FONT STYLE="font-size:10pt">(Zip Code)</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE="margin-top:12pt;margin-bottom:0pt;">
	 </P>
	 <HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="120">
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">Vion Pharmaceuticals, Inc. 2005 Stock
		Incentive Plan, as Amended and Restated</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<FONT STYLE="font-size:10pt">(Full title of the plan)</FONT>
	 </P>
	 <P STYLE="margin-top:12pt;margin-bottom:0pt;">
	 </P>
	 <HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="120">
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">Alan Kessman, Chief Executive
		Officer</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">Vion Pharmaceuticals, Inc.</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">4 Science Park</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">New Haven, Connecticut 06511</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<FONT STYLE="font-size:10pt">(Name and address of agent for
		service)</FONT>
	 </P>
	 <P STYLE="margin-top:12pt;margin-bottom:0pt;">
	 </P>
	 <HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="120">
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">(203) 498-4210</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<FONT STYLE="font-size:10pt">(Telephone number, including area code of
		agent for service)</FONT>
	 </P>
	 <P STYLE="margin-top:12pt;margin-bottom:0pt;">
	 </P>
	 <HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="120">
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<FONT STYLE="font-size:10pt">Copy to:</FONT>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">Paul Jacobs, Esq.</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">Lawrence A. Spector, Esq.</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">Fulbright &amp; Jaworski
		L.L.P.</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">666 Fifth Avenue</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">New York, New York 10103</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">Telephone (212) 318-3000</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">Fax (212) 318-3400</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="font-size:10pt">CALCULATION OF REGISTRATION
		FEE</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" margin-left:.1pt;border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="20%" VALIGN="bottom"
			  STYLE="border:solid black .5pt; border-top:double black 2.25pt;">
				<P
				 STYLE=" margin-left:0in;margin-right:0in;text-indent:0pt;text-align:center;margin-top:2.75pt;margin-bottom: 2.75pt;">
				  <FONT STYLE="font-size:8pt">Title of</FONT><BR>
				  <FONT STYLE="font-size:8pt">securities to be registered</FONT>
				</P>
			 </TD>
			 <TD WIDTH="19%" VALIGN="bottom"
			  STYLE="border-top:double black 2.25pt; border-left:none;border-bottom:solid black .5pt;border-right:solid black .5pt; ">

				<P
				 STYLE=" margin-left:0in;margin-right:0in;text-indent:0pt;text-align:center;margin-top:2.75pt;margin-bottom: 2.75pt;">
				  <FONT STYLE="font-size:8pt">Amount to be</FONT><BR>
				  <FONT STYLE="font-size:8pt">registered<SUP>(1) (2)</SUP></FONT>
				</P>
			 </TD>
			 <TD WIDTH="19%" VALIGN="bottom"
			  STYLE="border-top:double black 2.25pt; border-left:none;border-bottom:solid black .5pt;border-right:solid black .5pt; ">

				<P
				 STYLE=" margin-left:0in;margin-right:0in;text-indent:0pt;text-align:center;margin-top:2.75pt;margin-bottom: 2.75pt;">
				  <FONT STYLE="font-size:8pt">Proposed maximum</FONT><BR>
				  <FONT STYLE="font-size:8pt">offering price</FONT><BR>
				  <FONT STYLE="font-size:8pt">per share<SUP>(3)</SUP></FONT>
				</P>
			 </TD>
			 <TD WIDTH="19%" VALIGN="bottom"
			  STYLE="border-top:double black 2.25pt; border-left:none;border-bottom:solid black .5pt;border-right:solid black .5pt; ">

				<P
				 STYLE=" margin-left:0in;margin-right:0in;text-indent:0pt;text-align:center;margin-top:2.75pt;margin-bottom: 2.75pt;">
				  <FONT STYLE="font-size:8pt">Proposed maximum</FONT><BR>
				  <FONT STYLE="font-size:8pt">aggregate offering</FONT><BR>
				  <FONT STYLE="font-size:8pt">price<SUP>(3)</SUP></FONT>
				</P>
			 </TD>
			 <TD WIDTH="19%" VALIGN="bottom"
			  STYLE="border-top:double black 2.25pt; border-left:none;border-bottom:solid black .5pt;border-right:solid black .5pt; ">

				<P
				 STYLE=" margin-left:0in;margin-right:0in;text-indent:0pt;text-align:center;margin-top:2.75pt;margin-bottom: 2.75pt;">
				  <FONT STYLE="font-size:8pt">Amount of</FONT><BR>
				  <FONT STYLE="font-size:8pt">registration fee</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="bottom"
			  STYLE="border-top:none;border-left: solid black .5pt;border-bottom:double black 2.25pt;border-right: solid black .5pt;">

				<P
				 STYLE=" margin-left:0in;margin-right:0in;text-indent:0pt;text-align:left;margin-top:2.75pt;margin-bottom:2.75pt;">
				  <FONT STYLE="font-size:10pt">Common Stock, $0.01 par value per
				  share</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom"
			  STYLE="border-top:none;border-left: none;border-bottom:double black 2.25pt;border-right:solid black .5pt; ">

				<P
				 STYLE=" margin-left:0in;margin-right:0in;text-indent:0pt;text-align:center;margin-top:2.75pt;margin-bottom: 2.75pt;">
				  <FONT STYLE="font-size:10pt">3,089,911<SUP> (4)</SUP></FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom"
			  STYLE="border-top:none;border-left: none;border-bottom:double black 2.25pt;border-right:solid black .5pt; ">

				<P
				 STYLE=" margin-left:0in;margin-right:0in;text-indent:0pt;text-align:center;margin-top:2.75pt;margin-bottom: 2.75pt;">
				  <FONT STYLE="font-size:10pt">$0.75</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom"
			  STYLE="border-top:none;border-left: none;border-bottom:double black 2.25pt;border-right:solid black .5pt; ">

				<P
				 STYLE=" margin-left:0in;margin-right:0in;text-indent:0pt;text-align:center;margin-top:2.75pt;margin-bottom: 2.75pt;">
				  <FONT STYLE="font-size:10pt">$2,317,433.25</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom"
			  STYLE="border-top:none;border-left: none;border-bottom:double black 2.25pt;border-right:solid black .5pt; ">

				<P
				 STYLE=" margin-left:0in;margin-right:0in;text-indent:0pt;text-align:center;margin-top:2.75pt;margin-bottom: 2.75pt;">
				  <FONT STYLE="font-size:10pt">$71.15</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:8pt">(1)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:8pt">Pursuant to Rule 416 under the
				  Securities Act of 1933, as amended (the &#147;Securities Act&#148;), this
				  registration statement on Form S-8 (this &#147;Registration Statement&#148;)
				  shall also cover an additional indeterminable number of shares of common stock
				  which become issuable under the above-named plan by reason of any future stock
				  dividend, stock split, recapitalization or other similar transaction effected
				  without the receipt of consideration which results in an increase in the number
				  of outstanding shares of common stock.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:8pt">(2)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:8pt">All shares of common stock of the
				  Registrant carry rights to purchase  additional shares of the
				  Registrant&#146;s common stock, par value $0.01 per share under the
				  Registrant&#146;s Stockholder Rights Plan adopted October 15, 1998, as amended.
				  Such purchase rights are attached to and trade with the common stock. Value
				  attributable to such rights, if any, is reflected in the market price of the
				  common stock.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:8pt">(3)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:8pt">Estimated solely for purposes of
				  calculating the registration fee. Pursuant to Rules 457(c) and 457(h)(1) under
				  the Securities Act, based upon $0.75 the average of the high and low sales prices of
				  the Registrant&#146;s common stock, as reported on the Nasdaq Capital
				  Market<SUP>SM</SUP> on September 28, 2007.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:8pt">(4)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:8pt">Represents (i) 3,000,000 shares of Common
				  Stock authorized for future issuance under the Vion Pharmaceuticals, Inc. 2005
				  Stock Incentive Plan, as Amended and Restated, effective June 26, 2007 (the &#147;Plan&#148;); and (ii) 89,911 shares of Common Stock that were issuable upon exercise of options granted under the Registrant's 2003 Stock Option Plan, which options have been forfeited and transferred to the Plan.</FONT>				</P>
		    </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
<!-- EEDocs PBStart-->
<hr noshade="NOSHADE" align="center" width="100%"
	 size="2">
<P STYLE="page-break-before:always">	 </P>
	 <PAGE>
<!-- EEDocs PBEnd-->
<!-- EEDocs PBStart-->
<!-- EEDocs PBEnd-->
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:10PT">EXPLANATORY NOTE </FONT></B>
	 </P>
	 <P
	  STYLE=" margin-bottom:0pt; margin-top:8pt; text-indent:5%;text-align:left;">
		<FONT STYLE="font-size:10pt">Pursuant to General Instruction E to Form
		S-8 under the Securities Act, this Registration Statement is filed by Vion
		Pharmaceuticals, Inc. (&#147;Vion&#148; or the &#147;Company&#148;) for the
		purpose of registering additional shares of common stock, par value $0.01 per
		share, of the Company (the &#147;Common Stock&#148;) under the Vion
		Pharmaceuticals, Inc. 2005 Stock Incentive Plan (the &#147;Plan&#148;), as
		amended and restated, which are the same class of securities as those registered under the
		currently effective Registration Statement on Form S-8 (Registration No.
		333-129746) relating to the Plan, filed on November 16,&nbsp;2005 (the
		&#147;Prior Registration Statement&#148;), and the contents of such Prior
		Registration Statement, including any amendments thereto or filings
		incorporated therein, are incorporated herein by this reference. 7,441,907
		shares of Common Stock were registered for issuance under the Plan pursuant to
		the Prior Registration Statement. </FONT>
	 </P>
	 <P
	  STYLE=" margin-bottom:0pt; margin-top:8pt; text-indent:5%;text-align:left;">
		<FONT STYLE="font-size:10pt">On June&nbsp;26,&nbsp;2007, the shareholders
		of the Company approved an amendment to the Plan that increased the number of
		shares of Common Stock available for issuance under the Plan by 3,000,000 to
		10,531,818. This Registration Statement registers (i) the 3,000,000 additional
		shares of Common Stock authorized for issuance
		pursuant to awards made under the Plan as a result of the June 26, 2007
		amendment to the Plan and (ii) 89,911 shares of Common Stock that were issuable upon exercise of options granted under the Company's 2003 Stock Option Plan, which options have been forfeited and transferred to the Plan to date (in each case subject to adjustment in the event of stock splits, stock dividends and other extraordinary corporate events). Thus, upon effectiveness of this Registration Statement 10,531,818 shares of Common Stock will be registered for issuance under the Plan.</FONT></P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
<!-- EEDocs PBStart--><HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="100%"
	 SIZE="2">
	 <P STYLE="page-break-before:always">
	 </P>
	 <PAGE>
<!-- EEDocs PBEnd-->
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:10PT">PART II </FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:10PT">INFORMATION REQUIRED IN THE REGISTRATION
		STATEMENT </FONT></B>
	 </P>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="49%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="100%" VALIGN="top" STYLE="padding:12.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Item</FONT></B><FONT
				  STYLE="font-size:10pt">&nbsp;</FONT><B><FONT STYLE="font-size:10pt">3.
				  </FONT></B><FONT STYLE="font-size:10pt">&nbsp;&nbsp;</FONT><B><FONT
				  STYLE="font-size:10pt">Incorporation of Documents by Reference.</FONT></B>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P
	  STYLE=" margin-bottom:0pt; margin-top:8pt; text-indent:5%;text-align:left;">
		<FONT STYLE="font-size:10pt">The following documents have been filed by
		Vion Pharmaceuticals, Inc. (&#147;Vion,&#148; the &#147;Registrant&#148; or the
		&#147;Company&#148;) with the Securities and Exchange Commission (the
		&#147;Commission&#148;) and are hereby incorporated by reference into this
		Registration Statement:</FONT>
	 </P>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:4.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT SIZE="3"><B>&#149;</B></FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Vion&#146;s annual report on Form
				  10-K for the year ended December 31, 2006;</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:4.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT SIZE="3"><B>&#149;</B></FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Vion&#146;s quarterly reports on Form
				  10-Q for the quarters ended March 31, 2007 and June 30, 2007, respectively;</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:4.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT SIZE="3"><B>&#149;</B></FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Vion&#146;s current reports on Form
				  8-K filed on January 17, 2007, January 25, 2007, February 15, 2007, February
				  20, 2007, March 23, 2007, April 11, 2007, May 23, 2007, as amended by the Form
				  8-K/A filed on May 25, 2007, June 5, 2007, June 11, 2007, June 28, 2007, as
				  amended by the Form 8-K/A filed on June 29, 2007, August 15, 2007, August 16, 2007 and September 19, 2007 and the Form 8-K/A filed on
				  February 14, 2007 and Item 8.01 of the Form 8-K filed on August 10, 2007;</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:4.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT SIZE="3"><B>&#149;</B></FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">The description of Vion&#146;s
				  common stock contained in Item 1 of Vion&#146;s registration statement on Form
				  8-A, dated July 31, 1995;</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:4.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT SIZE="3"><B>&#149;</B></FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">The rights agreement, dated as of
				  October 26, 1998, included as Exhibit 4.1 to Vion&#146;s current report on Form
				  8-K filed on October 26, 1998, as amended by amendment No. 1 thereto, included
				  as Exhibit 4.1 to Vion&#146;s current report on Form 8-K filed on August 16,
				  2004; and</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:4.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT SIZE="3"><B>&#149;</B></FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Vion&#146;s registration statement
				  on Form 8-A, filed on October 26, 1998, as amended by amendment No. 1 thereto
				  on Form 8-A/A, filed on August 16, 2004.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
  <DIV ALIGN="left"></DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:8pt;text-align:left;">
		<FONT STYLE="font-size:10pt">In addition, all documents subsequently
		filed by the Company with the Commission pursuant to Sections&nbsp;13(a),
		13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, prior to
		the filing of a post-effective amendment to this Registration Statement which
		indicates that all securities offered hereby have been sold or which
		deregisters all securities then remaining unsold, shall be deemed to be
		incorporated by reference into this Registration Statement and to be a part
		hereof from the date of filing of such documents. &nbsp;Because Vion is
		incorporating by reference its future filings with the SEC, this Registration
		Statement is continually updated and those future filings may modify or
		supersede some or all of the information included or incorporated in this
		Registration Statement. This means that you must look at all of Vion&#146;s
		filings with the Commission that are incorporated by reference to determine if
		any of the statements in this Registration Statement or in any document
		previously incorporated by reference have been modified or superseded. </FONT>
	 </P>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="19%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="100%" VALIGN="top" STYLE="padding:12.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Item 8. </FONT></B><FONT
				  STYLE="font-size:10pt">&nbsp;&nbsp;</FONT><B><FONT
				  STYLE="font-size:10pt">Exhibits.</FONT></B>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P
	  STYLE=" margin-bottom:0pt; margin-top:8pt; text-indent:5%;text-align:left;"> <FONT STYLE="font-size:10pt">The following exhibits are filed herewith or
	   incorporated by reference as part of this Registration Statement. </FONT> </P>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:8pt"><U>Exhibit No.</U></FONT></B>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:8pt"><U>Description</U></FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD WIDTH="10%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">5.1</FONT>
				</P>
			 </TD>
			 <TD WIDTH="1%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="87%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Opinion of Fulbright &amp; Jaworski
				  L.L.P.</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">10.1</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Vion Pharmaceuticals, Inc. 2005
				  Stock Incentive Plan, as amended and restated* </FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">23.1</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Consent of Counsel (contained in
				  Exhibit 5.1)</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">23.2</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Consent of Independent Registered
				  Public Accounting Firm</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">24.1</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Power of Attorney (included in
				  signature page)</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:8pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">*</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:8pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Incorporated by reference to
				  Vion&#146;s quarterly report on Form 10-Q, for the quarter ended June 30, 2007.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
<!-- EEDocs PBStart--><HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="100%"
	 SIZE="2">
	 <P STYLE="page-break-before:always">
	 </P>
	 <PAGE>
<!-- EEDocs PBEnd-->
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="19%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="100%" VALIGN="top" STYLE="padding:12.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Item 9. </FONT></B><FONT
				  STYLE="font-size:10pt">&nbsp;&nbsp;</FONT><B><FONT
				  STYLE="font-size:10pt">Undertakings.</FONT></B>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(a)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">The undersigned registrant hereby
				  undertakes: </FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(1)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">To file, during any period in which
				  offers or sales are being made, a post-effective amendment to this registration
				  statement:</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="10%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(i)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">to include any prospectus required
				  by Section 10(a)(3) of the Securities Act of 1933;</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="10%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(ii)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">to reflect in the prospectus any
				  facts or events arising after the effective date of the registration statement
				  (or the most recent post-effective amendment thereof) which, individually or in
				  the aggregate, represent a fundamental change in the information set forth in
				  the registration statement. Notwithstanding the foregoing, any increase or
				  decrease in volume of securities offered (if the total dollar value of
				  securities offered would not exceed that which was registered) and any
				  deviation from the low or high end of the estimated maximum offering range may
				  be reflected in the form of prospectus filed with the Commission pursuant to
				  Rule 424(b) if, in the a gregate, the changes in volume and price represent no
				  more than 20 percent change in the maximum aggregate offering price set forth
				  in the &#147;Calculation of Registration Fee&#148; table in the effective
				  registration statement;</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="10%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(iii)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">to include any material information
				  with respect to the plan of distribution not previously disclosed in the
				  registration statement or any material change to such information in the
				  registration statement;</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:8pt;text-align:left;">
		<I><FONT STYLE="font-size:10pt">provided, however,</FONT></I><FONT
		STYLE="font-size:10pt"> that paragraphs (a)(1)(i) and (a)(1)(ii) of this
		section do not apply if the information required to be included in a
		post-effective amendment by those paragraphs is contained in reports filed with
		or furnished to the Commission by the registrant pursuant to section 13 or
		section 15(d) of the Securities Exchange Act of 1934 that are incorporated by
		reference in the registration statement. </FONT>
	 </P>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(2)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">That, for the purpose of determining
				  any liability under the Securities Act of 1933, each such post-effective
				  amendment shall be deemed to be a new registration statement relating to the
				  securities offered therein, and the offering of such securities at that time
				  shall be deemed to be the initial </FONT><I><FONT STYLE="font-size:10pt">bona
				  fide</FONT></I><FONT STYLE="font-size:10pt"> offering thereof.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(3)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">To remove from registration by means
				  of a post-effective amendment any of the securities being registered which
				  remain unsold at the termination of the offering.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(5)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">That, for the purpose of determining
				  liability under the Securities Act of 1933 to any purchaser:</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="10%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:6pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(ii)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">If the registrant is subject to Rule
				  430C, each prospectus filed pursuant to Rule 424(b) as part of a registration
				  statement relating to an offering, other than registration statements relying
				  on Rule 430B or other than prospectuses filed in reliance on Rule 430A, shall
				  be deemed to be part of and included in the registration statement as of the
				  date it is first used after effectiveness. Provided, however, that no statement
				  made in a registration statement or prospectus that is part of the registration
				  statement or made in a document incorporated or deemed incorporated by
				  reference into the registration statement or prospectus that is part of the
				  registration statement will, as to a purchaser with a time of contract of sale
				  prior to such first use, supersede or modify any statement that was made in the
				  registration statement or prospectus that was part of the registration
				  statement or made in any such document immediately prior to such date of first
				  use.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
<!-- EEDocs PBStart--><HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="100%"
	 SIZE="2">
	 <P STYLE="page-break-before:always">
	 </P>
	 <PAGE>
<!-- EEDocs PBEnd-->
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(b)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">The undersigned registrant hereby
				  undertakes that, for purposes of determining any liability under the Securities
				  Act of 1933, each fling of the registrant&#146;s annual report pursuant to
				  Section 13(a) or 15(d) of the Securities Exchange Act f 1934 (and, where
				  applicable, each filing of an employee benefit plan&#146;s annual report
				  pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is
				  incorporated by reference in the registration statement shall be deemed to be a
				  new registration statement relating to the securities offered therein, and the
				  offering of such securities at that time shall be deemed to be the initial
				  </FONT><I><FONT STYLE="font-size:10pt">bona fide</FONT></I><FONT
				  STYLE="font-size:10pt"> offering thereof.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">(h)</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:6.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Insofar as indemnification for
				  liabilities arising under the Securities Act of 1933 may be permitted to
				  directors, officers and controlling persons of the registrant pursuant to the
				  foregoing provisions, or otherwise, the registrant has been advised that in the
				  opinion of the Securities and Exchange Commission such indemnification is
				  against public policy as expressed in the Act and is, therefore, unenforceable.
				  In the event that a claim for indemnification against such liabilities (other
				  than the payment by the registrant and expenses incurred or paid by a director,
				  officer or controlling person of the registrant in the successful defense of
				  any action, suit or proceeding) is asserted by such director, officer or
				  controlling person in connection with the securities being registered, the
				  registrant will, unless in the opinion of its counsel the matter has been
				  settled by controlling precedent, submit to a court of appropriate jurisdiction
				  the question of whether such indemnification by it is against public policy as
				  expressed in the Act and will be governed by the final adjudication of such
				  issue.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
<!-- EEDocs PBStart--><HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="100%"
	 SIZE="2">
	 <P STYLE="page-break-before:always">
	 </P>
	 <PAGE>
<!-- EEDocs PBEnd-->
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
<!-- EEDocs PBStart-->
<!-- EEDocs PBEnd-->
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:11.5pt">&nbsp;</FONT>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:10PT">SIGNATURES</FONT></B>
	 </P>
	 <P
	  STYLE=" margin-bottom:0pt; margin-top:8pt; text-indent:5%;text-align:left;">
		<FONT STYLE="font-size:10pt">Pursuant to the requirements of the
		Securities Act of 1933, as amended, the Registrant certifies that it has
		reasonable grounds to believe that it meets all the requirements for filing on
		Form S-8 and has duly caused this Registration Statement to be signed on its
		behalf by the undersigned, thereunto duly authorized, in the City of New Haven,
		State of Connecticut, on October 1, 2007.</FONT>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
	 <DIV ALIGN="center">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD COLSPAN="2" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="FONT-SIZE:10PT">VION PHARMACEUTICALS,
				  INC.</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD WIDTH="49%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				</P>
			 </TD>
			 <TD WIDTH="7%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="2%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">By:&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="40%" VALIGN="bottom"
			  STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <BR> <FONT STYLE="font-size:10pt">/s/ Howard B. Johnson</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Howard B. Johnson</FONT><BR>
				  <FONT STYLE="font-size:10pt">President and Chief Financial Officer</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:10PT">POWER OF ATTORNEY </FONT></B>
	 </P>
	 <P
	  STYLE=" margin-bottom:0pt; margin-top:8pt; text-indent:5%;text-align:left;">
		<FONT STYLE="font-size:10pt">KNOW ALL MEN BY THESE PRESENTS, that each
		person whose signature appears below constitutes and appoints ALAN KESSMAN,
		HOWARD B. JOHNSON AND KAREN SCHMEDLIN, and each of them, his true and lawful
		attorneys-in-fact and agents, with full power of substitution and
		resubstitution, for him and his name, place and stead, and in any and all
		capacities, to sign any and all amendments to this registration statement
		(including post-effective amendments), and to file the same, with all exhibits
		thereto, and other documents in connection therewith, with the Securities and
		Exchange Commission, granting to said attorneys-in-fact and agents, and each of
		them, full power and authority to do and perform each and every act and thing
		requisite and necessary to be done, as fully to all intents and purposes as he
		might or could do in person, hereby ratifying and confirming all that said
		attorneys-in-fact and agents, or either of them, or their or his substitute or
		substitutes, may lawfully do or cause to be done by virtue thereof. </FONT>
	 </P>
	 <P
	  STYLE=" margin-bottom:0pt; margin-top:8pt; text-indent:5%;text-align:left;">
		<FONT STYLE="font-size:10pt">Pursuant to the requirements of the
		Securities Act of 1933, as amended, this registration statement has been signed
		below by the following persons in the capacities and on the dates
		indicated.</FONT>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
	 <DIV ALIGN="center">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="36%" VALIGN="bottom"
			  STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:8pt">Signature</FONT></B>
				</P>
			 </TD>
			 <TD WIDTH="3%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="38%" VALIGN="bottom"
			  STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:8pt">Title</FONT></B>
				</P>
			 </TD>
			 <TD WIDTH="2%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="19%" VALIGN="bottom"
			  STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:8pt">Date</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">/s/ William R. Miller</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Chairman of the Board of
				  Directors</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">October&nbsp;1,
				  2007</FONT>				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">William R. Miller</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">/s/ Alan Kessman</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Chief Executive Officer</FONT><BR>
				  <FONT STYLE="font-size:10pt">(Principal Executive Officer)</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">October 1,
				  2007</FONT>				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Alan Kessman</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">/s/ Howard B. Johnson</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">President and Chief Financial
				  Officer <BR>(Principal Financial Officer)</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">October&nbsp;1,
				  2007</FONT>				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Howard B. Johnson</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">/s/ Karen Schmedlin</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">VP Finance and Chief Accounting
				  Officer</FONT><BR> <FONT STYLE="font-size:10pt">(Principal Accounting
				  Officer)</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">October&nbsp;1,
				  2007</FONT>				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Karen Schmedlin</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">/s/ George Bickerstaff</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Director</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">October&nbsp;1,
				  2007</FONT>				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">George Bickerstaff</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">/s/ Stephen K. Carter, M.D.</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Director</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">October 1,
				  2007</FONT>				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Stephen K. Carter,
				  M.D.</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">/s/ Alan C. Sartorelli, Ph.D.</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Director</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">October&nbsp;1,
				  2007</FONT>				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Alan C. Sartorelli,
				  Ph.D.</FONT></B>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>

<!-- EEDocs PBStart--><HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="100%"
	 SIZE="2">
	 <P STYLE="page-break-before:always">
	 </P>
	 <PAGE>
<!-- EEDocs PBEnd-->
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
	 <DIV ALIGN="center">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="36%" VALIGN="bottom"
			  STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:8pt">Signature</FONT></B>
				</P>
			 </TD>
			 <TD WIDTH="3%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="38%" VALIGN="bottom"
			  STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:8pt">Title</FONT></B>
				</P>
			 </TD>
			 <TD WIDTH="2%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="19%" VALIGN="bottom"
			  STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:8pt">Date</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">/s/ Ian Williams, D. Phil.</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Director</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">October 1,
				  2007</FONT>				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Ian Williams, D. Phil.</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">/s/ Gary K. Willis&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Director</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">October&nbsp;1,
				  2007</FONT>				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Gary K. Willis</FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top" STYLE="border-bottom: solid black .5pt;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">/s/ Kevin Rakin</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Director</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD ROWSPAN="2" VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:center;margin-top:0in;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">October&nbsp;1,
				  2007</FONT>				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="top">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0in;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:10pt">Kevin Rakin</FONT></B>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>

<!-- EEDocs PBStart--><HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="100%"
	 SIZE="2">
	 <P STYLE="page-break-before:always">
	 </P>
	 <PAGE>
<!-- EEDocs PBEnd-->
	 <P STYLE=" margin-bottom:0pt; margin-top:16pt;text-align:center;">
		<B><FONT STYLE="FONT-SIZE:10PT">INDEX TO EXHIBITS</FONT></B>
	 </P>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>

	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:8pt"><U>Exhibit No.</U></FONT></B>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-bottom:0pt;">
				  <B><FONT STYLE="font-size:8pt"><U>Description</U></FONT></B>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD WIDTH="10%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">5.1</FONT>
				</P>
			 </TD>
			 <TD WIDTH="1%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD WIDTH="87%" VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Opinion of Fulbright &amp; Jaworski
				  L.L.P.</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">10.1</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Vion Pharmaceuticals, Inc. 2005
				  Stock Incentive Plan, as amended and restated* </FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">23.1</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Consent of Counsel (contained in
				  Exhibit 5.1)</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">23.2</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Consent of Independent Registered
				  Public Accounting Firm</FONT>
				</P>
			 </TD>
		  </TR>
		  <TR>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:8.65pt;text-indent:-8.65pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">24.1</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0in;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">&nbsp;</FONT>
				</P>
			 </TD>
			 <TD VALIGN="bottom">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:2pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Power of Attorney (included in
				  signature page)</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <DIV ALIGN="left">
		<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" WIDTH="100%"
		 STYLE=" border-collapse:collapse;">
		  <TR>
			 <TD WIDTH="5%" VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">*</FONT>
				</P>
			 </TD>
			 <TD VALIGN="top" STYLE="padding:3.0pt 0in 0in 0in;">
				<P
				 STYLE=" margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt;">
				  <FONT STYLE="font-size:10pt">Incorporated by reference to
				  Vion&#146;s quarterly report on Form 10-Q, for the quarter ended June 30,  2007.</FONT>
				</P>
			 </TD>
		  </TR>
		</TABLE> </DIV>
	 <P STYLE=" margin-bottom:0pt; margin-top:0pt;text-align:left;">
		<FONT STYLE="font-size:10pt">&nbsp;</FONT>
	 </P>
<!-- EEDocs PBStart--><HR NOSHADE="NOSHADE" ALIGN="center" WIDTH="100%"
	 SIZE="2">
<!-- EEDocs PBEnd-->
<!-- EEDocs PBStart-->
<!-- EEDocs PBEnd-->

</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "file1.htm", "description": "FORM S-8", "secsgml_size_bytes": 88411}]
{"company-data": {"conformed-name": "VION PHARMACEUTICALS INC", "cik": "0000944522", "assigned-sic": "2836", "irs-number": "133671221", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-146426", "film-number": "071146839"}, "business-address": {"street1": "4 SCIENCE PARK", "city": "NEW HAVEN", "state": "CT", "zip": "06511", "phone": "2034984210"}, "mail-address": {"street1": "FOUR SCIENCE PARK", "city": "NEW HAVEN", "state": "CT", "zip": "06511"}, "former-company": {"former-conformed-name": "ONCORX INC", "date-changed": "19950615"}}
As filed with the Securities and Exchange
		Commission on October 1, 2007
Registration No.
				  333-
UNITED STATES
SECURITIES AND EXCHANGE
		COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE
		SECURITIES ACT OF 1933
VION PHARMACEUTICALS, INC.
(Exact name of registrant as specified in
		its charter)
Delaware
13-3671221
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer Identification
				  No.)
4 Science Park
New Haven, Connecticut
06511
(Address of principal executive
				  offices)
(Zip Code)
Vion Pharmaceuticals, Inc. 2005 Stock
		Incentive Plan, as Amended and Restated
(Full title of the plan)
Alan Kessman, Chief Executive
		Officer
Vion Pharmaceuticals, Inc.
4 Science Park
New Haven, Connecticut 06511
(Name and address of agent for
		service)
(203) 498-4210
(Telephone number, including area code of
		agent for service)
Copy to:
Paul Jacobs, Esq.
Lawrence A. Spector, Esq.
Fulbright & Jaworski
		L.L.P.
666 Fifth Avenue
New York, New York 10103
Telephone (212) 318-3000
Fax (212) 318-3400
CALCULATION OF REGISTRATION
		FEE
Title of
securities to be registered
Amount to be
registered
(1) (2)
Proposed maximum
offering price
per share
(3)
Proposed maximum
aggregate offering
price
(3)
Amount of
registration fee
Common Stock, $0.01 par value per
				  share
3,089,911
(4)
$0.75
$2,317,433.25
$71.15
(1)
Pursuant to Rule 416 under the
				  Securities Act of 1933, as amended (the "Securities Act"), this
				  registration statement on Form S-8 (this "Registration Statement")
				  shall also cover an additional indeterminable number of shares of common stock
				  which become issuable under the above-named plan by reason of any future stock
				  dividend, stock split, recapitalization or other similar transaction effected
				  without the receipt of consideration which results in an increase in the number
				  of outstanding shares of common stock.
(2)
All shares of common stock of the
				  Registrant carry rights to purchase  additional shares of the
				  Registrant's common stock, par value $0.01 per share under the
				  Registrant's Stockholder Rights Plan adopted October 15, 1998, as amended.
				  Such purchase rights are attached to and trade with the common stock. Value
				  attributable to such rights, if any, is reflected in the market price of the
				  common stock.
(3)
Estimated solely for purposes of
				  calculating the registration fee. Pursuant to Rules 457(c) and 457(h)(1) under
				  the Securities Act, based upon $0.75 the average of the high and low sales prices of
				  the Registrant's common stock, as reported on the Nasdaq Capital
				  Market
SM
on September 28, 2007.
(4)
Represents (i) 3,000,000 shares of Common
				  Stock authorized for future issuance under the Vion Pharmaceuticals, Inc. 2005
				  Stock Incentive Plan, as Amended and Restated, effective June 26, 2007 (the "Plan"); and (ii) 89,911 shares of Common Stock that were issuable upon exercise of options granted under the Registrant's 2003 Stock Option Plan, which options have been forfeited and transferred to the Plan.
EXPLANATORY NOTE
Pursuant to General Instruction E to Form
		S-8 under the Securities Act, this Registration Statement is filed by Vion
		Pharmaceuticals, Inc. ("Vion" or the "Company") for the
		purpose of registering additional shares of common stock, par value $0.01 per
		share, of the Company (the "Common Stock") under the Vion
		Pharmaceuticals, Inc. 2005 Stock Incentive Plan (the "Plan"), as
		amended and restated, which are the same class of securities as those registered under the
		currently effective Registration Statement on Form S-8 (Registration No.
		333-129746) relating to the Plan, filed on November 16, 2005 (the
		"Prior Registration Statement"), and the contents of such Prior
		Registration Statement, including any amendments thereto or filings
		incorporated therein, are incorporated herein by this reference. 7,441,907
		shares of Common Stock were registered for issuance under the Plan pursuant to
		the Prior Registration Statement.
On June 26, 2007, the shareholders
		of the Company approved an amendment to the Plan that increased the number of
		shares of Common Stock available for issuance under the Plan by 3,000,000 to
		10,531,818. This Registration Statement registers (i) the 3,000,000 additional
		shares of Common Stock authorized for issuance
		pursuant to awards made under the Plan as a result of the June 26, 2007
		amendment to the Plan and (ii) 89,911 shares of Common Stock that were issuable upon exercise of options granted under the Company's 2003 Stock Option Plan, which options have been forfeited and transferred to the Plan to date (in each case subject to adjustment in the event of stock splits, stock dividends and other extraordinary corporate events). Thus, upon effectiveness of this Registration Statement 10,531,818 shares of Common Stock will be registered for issuance under the Plan.
PART II
INFORMATION REQUIRED IN THE REGISTRATION
		STATEMENT
Item
3.
Incorporation of Documents by Reference.
The following documents have been filed by
		Vion Pharmaceuticals, Inc. ("Vion," the "Registrant" or the
		"Company") with the Securities and Exchange Commission (the
		"Commission") and are hereby incorporated by reference into this
		Registration Statement:
•
Vion's annual report on Form
				  10-K for the year ended December 31, 2006;
•
Vion's quarterly reports on Form
				  10-Q for the quarters ended March 31, 2007 and June 30, 2007, respectively;
•
Vion's current reports on Form
				  8-K filed on January 17, 2007, January 25, 2007, February 15, 2007, February
				  20, 2007, March 23, 2007, April 11, 2007, May 23, 2007, as amended by the Form
				  8-K/A filed on May 25, 2007, June 5, 2007, June 11, 2007, June 28, 2007, as
				  amended by the Form 8-K/A filed on June 29, 2007, August 15, 2007, August 16, 2007 and September 19, 2007 and the Form 8-K/A filed on
				  February 14, 2007 and Item 8.01 of the Form 8-K filed on August 10, 2007;
•
The description of Vion's
				  common stock contained in Item 1 of Vion's registration statement on Form
				  8-A, dated July 31, 1995;
•
The rights agreement, dated as of
				  October 26, 1998, included as Exhibit 4.1 to Vion's current report on Form
				  8-K filed on October 26, 1998, as amended by amendment No. 1 thereto, included
				  as Exhibit 4.1 to Vion's current report on Form 8-K filed on August 16,
				  2004; and
•
Vion's registration statement
				  on Form 8-A, filed on October 26, 1998, as amended by amendment No. 1 thereto
				  on Form 8-A/A, filed on August 16, 2004.
In addition, all documents subsequently
		filed by the Company with the Commission pursuant to Sections 13(a),
		13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, prior to
		the filing of a post-effective amendment to this Registration Statement which
		indicates that all securities offered hereby have been sold or which
		deregisters all securities then remaining unsold, shall be deemed to be
		incorporated by reference into this Registration Statement and to be a part
		hereof from the date of filing of such documents.  Because Vion is
		incorporating by reference its future filings with the SEC, this Registration
		Statement is continually updated and those future filings may modify or
		supersede some or all of the information included or incorporated in this
		Registration Statement. This means that you must look at all of Vion's
		filings with the Commission that are incorporated by reference to determine if
		any of the statements in this Registration Statement or in any document
		previously incorporated by reference have been modified or superseded.
Item 8.
Exhibits.
The following exhibits are filed herewith or
	   incorporated by reference as part of this Registration Statement.
Exhibit No.
Description
5.1
Opinion of Fulbright & Jaworski
				  L.L.P.
10.1
Vion Pharmaceuticals, Inc. 2005
				  Stock Incentive Plan, as amended and restated*
23.1
Consent of Counsel (contained in
				  Exhibit 5.1)
23.2
Consent of Independent Registered
				  Public Accounting Firm
24.1
Power of Attorney (included in
				  signature page)
*
Incorporated by reference to
				  Vion's quarterly report on Form 10-Q, for the quarter ended June 30, 2007.
Item 9.
Undertakings.
(a)
The undersigned registrant hereby
				  undertakes:
(1)
To file, during any period in which
				  offers or sales are being made, a post-effective amendment to this registration
				  statement:
(i)
to include any prospectus required
				  by Section 10(a)(3) of the Securities Act of 1933;
(ii)
to reflect in the prospectus any
				  facts or events arising after the effective date of the registration statement
				  (or the most recent post-effective amendment thereof) which, individually or in
				  the aggregate, represent a fundamental change in the information set forth in
				  the registration statement. Notwithstanding the foregoing, any increase or
				  decrease in volume of securities offered (if the total dollar value of
				  securities offered would not exceed that which was registered) and any
				  deviation from the low or high end of the estimated maximum offering range may
				  be reflected in the form of prospectus filed with the Commission pursuant to
				  Rule 424(b) if, in the a gregate, the changes in volume and price represent no
				  more than 20 percent change in the maximum aggregate offering price set forth
				  in the "Calculation of Registration Fee" table in the effective
				  registration statement;
(iii)
to include any material information
				  with respect to the plan of distribution not previously disclosed in the
				  registration statement or any material change to such information in the
				  registration statement;
provided, however,
that paragraphs (a)(1)(i) and (a)(1)(ii) of this
		section do not apply if the information required to be included in a
		post-effective amendment by those paragraphs is contained in reports filed with
		or furnished to the Commission by the registrant pursuant to section 13 or
		section 15(d) of the Securities Exchange Act of 1934 that are incorporated by
		reference in the registration statement.
(2)
That, for the purpose of determining
				  any liability under the Securities Act of 1933, each such post-effective
				  amendment shall be deemed to be a new registration statement relating to the
				  securities offered therein, and the offering of such securities at that time
				  shall be deemed to be the initial
bona
				  fide
offering thereof.
(3)
To remove from registration by means
				  of a post-effective amendment any of the securities being registered which
				  remain unsold at the termination of the offering.
(5)
That, for the purpose of determining
				  liability under the Securities Act of 1933 to any purchaser:
(ii)
If the registrant is subject to Rule
				  430C, each prospectus filed pursuant to Rule 424(b) as part of a registration
				  statement relating to an offering, other than registration statements relying
				  on Rule 430B or other than prospectuses filed in reliance on Rule 430A, shall
				  be deemed to be part of and included in the registration statement as of the
				  date it is first used after effectiveness. Provided, however, that no statement
				  made in a registration statement or prospectus that is part of the registration
				  statement or made in a document incorporated or deemed incorporated by
				  reference into the registration statement or prospectus that is part of the
				  registration statement will, as to a purchaser with a time of contract of sale
				  prior to such first use, supersede or modify any statement that was made in the
				  registration statement or prospectus that was part of the registration
				  statement or made in any such document immediately prior to such date of first
				  use.
(b)
The undersigned registrant hereby
				  undertakes that, for purposes of determining any liability under the Securities
				  Act of 1933, each fling of the registrant's annual report pursuant to
				  Section 13(a) or 15(d) of the Securities Exchange Act f 1934 (and, where
				  applicable, each filing of an employee benefit plan's annual report
				  pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is
				  incorporated by reference in the registration statement shall be deemed to be a
				  new registration statement relating to the securities offered therein, and the
				  offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(h)
Insofar as indemnification for
				  liabilities arising under the Securities Act of 1933 may be permitted to
				  directors, officers and controlling persons of the registrant pursuant to the
				  foregoing provisions, or otherwise, the registrant has been advised that in the
				  opinion of the Securities and Exchange Commission such indemnification is
				  against public policy as expressed in the Act and is, therefore, unenforceable.
				  In the event that a claim for indemnification against such liabilities (other
				  than the payment by the registrant and expenses incurred or paid by a director,
				  officer or controlling person of the registrant in the successful defense of
				  any action, suit or proceeding) is asserted by such director, officer or
				  controlling person in connection with the securities being registered, the
				  registrant will, unless in the opinion of its counsel the matter has been
				  settled by controlling precedent, submit to a court of appropriate jurisdiction
				  the question of whether such indemnification by it is against public policy as
				  expressed in the Act and will be governed by the final adjudication of such
				  issue.
SIGNATURES
Pursuant to the requirements of the
		Securities Act of 1933, as amended, the Registrant certifies that it has
		reasonable grounds to believe that it meets all the requirements for filing on
		Form S-8 and has duly caused this Registration Statement to be signed on its
		behalf by the undersigned, thereunto duly authorized, in the City of New Haven,
		State of Connecticut, on October 1, 2007.
VION PHARMACEUTICALS,
				  INC.
By:
/s/ Howard B. Johnson
Howard B. Johnson
President and Chief Financial Officer
POWER OF ATTORNEY
KNOW ALL MEN BY THESE PRESENTS, that each
		person whose signature appears below constitutes and appoints ALAN KESSMAN,
		HOWARD B. JOHNSON AND KAREN SCHMEDLIN, and each of them, his true and lawful
		attorneys-in-fact and agents, with full power of substitution and
		resubstitution, for him and his name, place and stead, and in any and all
		capacities, to sign any and all amendments to this registration statement
		(including post-effective amendments), and to file the same, with all exhibits
		thereto, and other documents in connection therewith, with the Securities and
		Exchange Commission, granting to said attorneys-in-fact and agents, and each of
		them, full power and authority to do and perform each and every act and thing
		requisite and necessary to be done, as fully to all intents and purposes as he
		might or could do in person, hereby ratifying and confirming all that said
		attorneys-in-fact and agents, or either of them, or their or his substitute or
		substitutes, may lawfully do or cause to be done by virtue thereof.
Pursuant to the requirements of the
		Securities Act of 1933, as amended, this registration statement has been signed
		below by the following persons in the capacities and on the dates
		indicated.
Signature
Title
Date
/s/ William R. Miller
Chairman of the Board of
				  Directors
October 1,
				  2007
William R. Miller
/s/ Alan Kessman
Chief Executive Officer
(Principal Executive Officer)
October 1,
				  2007
Alan Kessman
/s/ Howard B. Johnson
President and Chief Financial
				  Officer
(Principal Financial Officer)
October 1,
				  2007
Howard B. Johnson
/s/ Karen Schmedlin
VP Finance and Chief Accounting
				  Officer
(Principal Accounting
				  Officer)
October 1,
				  2007
Karen Schmedlin
/s/ George Bickerstaff
Director
October 1,
				  2007
George Bickerstaff
/s/ Stephen K. Carter, M.D.
Director
October 1,
				  2007
Stephen K. Carter,
				  M.D.
/s/ Alan C. Sartorelli, Ph.D.
Director
October 1,
				  2007
Alan C. Sartorelli,
				  Ph.D.
Signature
Title
Date
/s/ Ian Williams, D. Phil.
Director
October 1,
				  2007
Ian Williams, D. Phil.
/s/ Gary K. Willis
Director
October 1,
				  2007
Gary K. Willis
/s/ Kevin Rakin
Director
October 1,
				  2007
Kevin Rakin
INDEX TO EXHIBITS
Exhibit No.
Description
5.1
Opinion of Fulbright & Jaworski
				  L.L.P.
10.1
Vion Pharmaceuticals, Inc. 2005
				  Stock Incentive Plan, as amended and restated*
23.1
Consent of Counsel (contained in
				  Exhibit 5.1)
23.2
Consent of Independent Registered
				  Public Accounting Firm
24.1
Power of Attorney (included in
				  signature page)
*
Incorporated by reference to
				  Vion's quarterly report on Form 10-Q, for the quarter ended June 30,  2007.