<PAGE>   1
    As filed with the Securities and Exchange Commission on November 15,1999
                              Registration No. 333-



                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                        ---------------------------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                        ---------------------------------


                         AMERICAN BIO MEDICA CORPORATION
             (Exact name of registrant as specified in its charter)


             New York                                    14-1702188
     ----------------------------               ----------------------------
     (State or other jurisdiction               (IRS employer identification
   of incorporation or organization)                      number)

                    122 Smith Road, Kinderhook, NY               12106
            --------------------------------------------       ---------
              (Address of principal executive offices)         (Zip code)

                   FISCAL 1998 NON-STATUTORY STOCK OPTION PLAN

                   FISCAL 2000 NON-STATUTORY STOCK OPTION PLAN

                   ------------------------------------------
                              (Full title of plans)

                                 Stan Cipkowski
             President/Chief Executive Officer/Chairman of the Board
                       c/o American Bio Medica Corporation
                      122 Smith Road, Kinderhook, NY 12106

                                  800-227-1243
                                  ------------
                      (Name, address and telephone number,
                   including area code, of agent for service)


                         CALCULATION OF REGISTRATION FEE
                         ===============================
--------------------------------------------------------------------------------

                                                   Proposed
                                    Proposed       Maximum
Title of each class     Amount       maximum       aggregate        Amount of
 of securities          to be     offering price   offering       registration
to be registered      registered   per unit (2)    price (1)          fee
--------------------------------------------------------------------------------
Common Shares(2)       1,000,000      N/A        $2,919,728        $  811.68

Common Shares(3)       1,000,000      N/A        $1,610,000        $  447.58
                                                                   ---------
                                           Total registration fee  $1,259.26

(1)   Estimated solely for the purpose of calculating the registration fee.

(2)   These Common Shares are offered under the Company's Fiscal 1998
      Non-Statutory Stock Option Plan. Pursuant to Rule 457(h)( 1), the filing
      fee for the 942,250 Common Shares subject to options that have been
      granted is calculated based upon the weighted average of the various
      strike prices of such shares, which is $3.00. Pursuant to Rule 457(h)( 1),
      the filing fee for the 57,750 Common Shares subject to options that have
      not yet been granted is calculated based upon the average of the bid and
      asked prices per Common Share on November 1, 1999, as reported on the
      Nasdaq SmallCap Market, which was $1.61 per share.

(3)   These Common Shares are offered under the Company's Fiscal 2000
      Non-Statutory Stock Option Plan. Pursuant to Rule 457(h)( 1), the filing
      fee for the 1,000,000 Common Shares subject to options that have not yet
      been granted is calculated based upon the average of the bid and asked
      prices per Common Share on November 1, 1999, which was $1.61 per share.


<PAGE>   2


                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

     In accordance with Rule 428 under the Securities Act of 1933, as amended,
and the Note to Part I of Form S-8, the information required by Part I to be
contained in the Section 10(a) prospectus has been omitted from this
registration statement.

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.

     The following documents filed by American Bio Medica Corporation (the
"Company") with the Securities and Exchange Commission (the "Commission") are
incorporated by reference in this Registration Statement:

     (1)  The Company's Annual Report on Form 10-KSB for the year ended April
          30, 1999;

     (2)  The Company's Quarterly Report on Form 10-QSB for the quarter ended
          July 31, 1999;

     (3)  The Company's current report on Form 8-K filed with the Commission on
          September 16, 1999; and

     (4)  The Company's Registration Statement on Form 8-A registering the
          Common Shares under Section 12(g) of the Securities Exchange Act of
          1934 (the "Exchange Act").

     All documents subsequently filed by the Company pursuant to Sections
13(a),13(c),14 and 15(d) of the Exchange Act, prior to the filing of a
post-effective amendment which indicates that all securities offered have been
sold or which deregisters all securities then remaining unsold, shall be deemed
to be incorporated by reference in this registration statement and to be part
hereof from the date of filing of such documents.

Item 4.  Description of Securities.

     Not applicable.

Item 5.  Interests of Named Experts and Counsel.

     Not applicable.

Item 6.  Indemnification of Directors and Officers.

     Article 9 of this Company's Certificate of Incorporation permits the
indemnification of officers and directors under certain circumstances to the
full extent that such indemnification may be permitted by law.

     Such rights of indemnification are in addition to, and not in limitation
of, any rights to indemnification to which any officer or director of the
Company is entitled to under the Business Corporation Law of the State of New


                                       2

<PAGE>   3

York which provides for indemnification by a corporation of its officers and
directors under certain circumstances as stated in the Business Corporation Law
and subject to specified limitations set forth in the Business Corporation Law.

Item 7.  Exemption from Registration Claimed.

     Not applicable.

Item 8.  Exhibits.

     See Exhibit Index on Page E-1.

Item 9.  UNDERTAKINGS

     Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities Act
of 1933 (the "Securities Act") and is, therefore, unenforceable. In the event
that a claim for indemnification against such liabilities (other than the
payment by the Registrant of expenses incurred or paid by a director, officer or
controlling person of the Registrant in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling person
in connection with the securities being registered, the Registrant will, unless
in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the
Securities Act and will be governed by the final adjudication of such issue.

     The undersigned hereby undertakes:

(a)  to file, during any period in which offers or sales are being made, a
     post-effective amendment to this Registration Statement:

    (i)   to include any prospectus required by section 10(a)( 3 ) of the
          Securities Act;

    (ii)  to reflect in the prospectus any facts or events arising after the
          effective date of this Registration Statement (or the most recent
          post-effective amendment thereof) which, individually or in the
          aggregate, represent a fundamental change in the information set forth
          in this Registration Statement; and

    (iii) to include any material information with respect to the plan of
          distribution not previously disclosed in this Registration Statement
          or any material change to such information in this Registration
          Statement;

     Provided, however, that paragraphs (1)(i) and (1)(ii) do not apply if the
information required to be included in a post effective amendment by these
paragraphs is contained in periodic reports filed by the Company pursuant to
Section 13 or Section 15(d) of the Securities Exchange Act of 1934 (the
"Exchange Act") that are incorporated by reference in this Registration
Statement.

    (b)   that, for the purposes of determining any liability under the
          Securities Act, each such post-effective amendment shall be deemed to
          be a new registration statement relating to the securities offered
          therein, and

                                       3

<PAGE>   4

          the offering of such securities at that time shall be deemed to be the
          initial bona fide offering thereof;

    (c)   to remove from registration by means of a post-effective amendment any
          of the securities being registered which remain unsold at the
          termination of the offering;

    (d)   That,for purposes of determining any liability under the Securities
          Act, each filing of the Company's annual report pursuant to Section
          13(a) or 15(d) of the Exchange Act(and, where applicable, each filing
          of an employee benefits plan's annual report pursuant to Section 15(d)
          of the Exchange Act) that is incorporated by reference in the
          Registration Statement shall be deemed to be a new registration
          statement relating to the securities offered herein, and the offering
          of such securities at that time shall be deemed to be the initial bona
          fide offering thereof.





                                 SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Kinderhook, State of New York on November 11, 1999.



                                AMERICAN BIO MEDICA CORPORATION
                                     (Registrant)

                                    By: /s/Stan Cipkowski
                                        ------------------
                                        Stan Cipkowski,
                                        President, Chief Executive Officer, &
                                        Chairman of the Board of Directors





                                       4

<PAGE>   5


                                POWER OF ATTORNEY

Each of the undersigned officers and directors of American Bio Medica
Corporation whose signature appears below hereby appoints Stan Cipkowski and
John F. Murray, and each of them, as true and lawful attorney-in-fact for the
undersigned with full power of substitution, to execute in his name and on his
behalf in each capacity stated below, any and all amendments (including
post-effective amendments) to this Registration Statement as the
attorney-in-fact shall deem appropriate, and to cause to be filed any such
amendment (including exhibits thereto and other documents in connection
therewith) to this Registration Statement with the Securities and Exchange
Commission, as fully and to all intents and purposes as such person might or
could do in person, hereby ratifying and confirming all that said
attorneys-in-fact, or any of them, may lawfully do or cause to be done by virtue
herewith.

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities indicated on November 11, 1999:

        Signature                           Title
        ---------                           -----

/s/Stan Cipkowski                 President, Chief Executive Officer,
---------------------             & Chairman of the Board of Directors
Stan Cipkowski                    (Principal Executive Officer)

/s/Edmund Jaskiewicz
---------------------             Director & Secretary
Edmund Jaskiewicz

/s/Jay Bendis                     Director & Vice President Sales &
---------------------             Marketing
Jay Bendis

/s/John F. Murray                 Director,Treasurer, Chief Financial Officer
---------------------             (Principal Financial Officer)
John F. Murray


---------------------
Gerald Moore                      Director


---------------------
Karen Russo                       Director


                                       5

<PAGE>   6
                                                                       PAGE E-1

                               INDEX TO EXHIBITS

   Exhibit                         Description
   -------                         -----------


    3.07       Fifth Amendment to Certificate of Incorporation*

    5.01       Opinion and Consent of Hopkins & Sutter

    10.01      Fiscal 1998 Non-Statutory Stock Option Plan (filed as part of the
               Company's Proxy Statement for its Fiscal 1998 Annual Meeting and
               incorporated herein by reference)

    10.02      Fiscal 2000 Non-Statutory Stock Option Plan (filed as part of the
               Company's Proxy Statement for its Fiscal 2000 Annual Meeting and
               incorporated herein by reference)

    23.01      Consent of Richard A. Eisner & Company, LLP

    23.02      Consent of Hopkins & Sutter(contained in Exhibit 5.01)

-----------------------------

        *      Previously filed as an exhibit to Registration Statement on
               Form SB-2 filed on May 20, 1998 and incorporated herein by
               reference
[{"type": "S-8", "sequence": "1", "description": "FORM S-8", "secsgml_size_bytes": 14502}]
{"company-data": {"conformed-name": "AMERICAN BIO MEDICA CORP", "cik": "0000896747", "assigned-sic": "3829", "irs-number": "141702188", "state-of-incorporation": "NY", "fiscal-year-end": "0430"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-91025", "film-number": "99758533"}, "business-address": {"street1": "122 SMITH ROAD", "city": "KINDERHOOK", "state": "NY", "zip": "12106", "phone": "8002271243"}, "mail-address": {"street1": "122 SMITH ROAD", "city": "KINDERHOOK", "state": "NY", "zip": "12106"}}
1
    As filed with the Securities and Exchange Commission on November 15,1999
                              Registration No. 333-

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                        ---------------------------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                        ---------------------------------

                         AMERICAN BIO MEDICA CORPORATION
             (Exact name of registrant as specified in its charter)

             New York                                    14-1702188
     ----------------------------               ----------------------------
     (State or other jurisdiction               (IRS employer identification
   of incorporation or organization)                      number)

                    122 Smith Road, Kinderhook, NY               12106
            --------------------------------------------       ---------
              (Address of principal executive offices)         (Zip code)

                   FISCAL 1998 NON-STATUTORY STOCK OPTION PLAN

                   FISCAL 2000 NON-STATUTORY STOCK OPTION PLAN

                   ------------------------------------------
                              (Full title of plans)

                                 Stan Cipkowski
             President/Chief Executive Officer/Chairman of the Board
                       c/o American Bio Medica Corporation
                      122 Smith Road, Kinderhook, NY 12106

                                  800-227-1243
                                  ------------
                      (Name, address and telephone number,
                   including area code, of agent for service)

                         CALCULATION OF REGISTRATION FEE
                         ===============================
--------------------------------------------------------------------------------

                                                   Proposed
                                    Proposed       Maximum
Title of each class     Amount       maximum       aggregate        Amount of
 of securities          to be     offering price   offering       registration
to be registered      registered   per unit (2)    price (1)          fee
--------------------------------------------------------------------------------
Common Shares(2)       1,000,000      N/A        $2,919,728        $  811.68

Common Shares(3)       1,000,000      N/A        $1,610,000        $  447.58
                                                                   ---------
                                           Total registration fee  $1,259.26

(1)   Estimated solely for the purpose of calculating the registration fee.

(2)   These Common Shares are offered under the Company's Fiscal 1998
      Non-Statutory Stock Option Plan. Pursuant to Rule 457(h)( 1), the filing
      fee for the 942,250 Common Shares subject to options that have been
      granted is calculated based upon the weighted average of the various
      strike prices of such shares, which is $3.00. Pursuant to Rule 457(h)( 1),
      the filing fee for the 57,750 Common Shares subject to options that have
      not yet been granted is calculated based upon the average of the bid and
      asked prices per Common Share on November 1, 1999, as reported on the
      Nasdaq SmallCap Market, which was $1.61 per share.

(3)   These Common Shares are offered under the Company's Fiscal 2000
      Non-Statutory Stock Option Plan. Pursuant to Rule 457(h)( 1), the filing
      fee for the 1,000,000 Common Shares subject to options that have not yet
      been granted is calculated based upon the average of the bid and asked
      prices per Common Share on November 1, 1999, which was $1.61 per share.
2

                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

     In accordance with Rule 428 under the Securities Act of 1933, as amended,
and the Note to Part I of Form S-8, the information required by Part I to be
contained in the Section 10(a) prospectus has been omitted from this
registration statement.

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.

     The following documents filed by American Bio Medica Corporation (the
"Company") with the Securities and Exchange Commission (the "Commission") are
incorporated by reference in this Registration Statement:

     (1)  The Company's Annual Report on Form 10-KSB for the year ended April
          30, 1999;

     (2)  The Company's Quarterly Report on Form 10-QSB for the quarter ended
          July 31, 1999;

     (3)  The Company's current report on Form 8-K filed with the Commission on
          September 16, 1999; and

     (4)  The Company's Registration Statement on Form 8-A registering the
          Common Shares under Section 12(g) of the Securities Exchange Act of
          1934 (the "Exchange Act").

     All documents subsequently filed by the Company pursuant to Sections
13(a),13(c),14 and 15(d) of the Exchange Act, prior to the filing of a
post-effective amendment which indicates that all securities offered have been
sold or which deregisters all securities then remaining unsold, shall be deemed
to be incorporated by reference in this registration statement and to be part
hereof from the date of filing of such documents.

Item 4.  Description of Securities.

     Not applicable.

Item 5.  Interests of Named Experts and Counsel.

     Not applicable.

Item 6.  Indemnification of Directors and Officers.

     Article 9 of this Company's Certificate of Incorporation permits the
indemnification of officers and directors under certain circumstances to the
full extent that such indemnification may be permitted by law.

     Such rights of indemnification are in addition to, and not in limitation
of, any rights to indemnification to which any officer or director of the
Company is entitled to under the Business Corporation Law of the State of New

                                       2
3

York which provides for indemnification by a corporation of its officers and
directors under certain circumstances as stated in the Business Corporation Law
and subject to specified limitations set forth in the Business Corporation Law.

Item 7.  Exemption from Registration Claimed.

     Not applicable.

Item 8.  Exhibits.

     See Exhibit Index on Page E-1.

Item 9.  UNDERTAKINGS

     Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities Act
of 1933 (the "Securities Act") and is, therefore, unenforceable. In the event
that a claim for indemnification against such liabilities (other than the
payment by the Registrant of expenses incurred or paid by a director, officer or
controlling person of the Registrant in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling person
in connection with the securities being registered, the Registrant will, unless
in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the
Securities Act and will be governed by the final adjudication of such issue.

     The undersigned hereby undertakes:

(a)  to file, during any period in which offers or sales are being made, a
     post-effective amendment to this Registration Statement:

    (i)   to include any prospectus required by section 10(a)( 3 ) of the
          Securities Act;

    (ii)  to reflect in the prospectus any facts or events arising after the
          effective date of this Registration Statement (or the most recent
          post-effective amendment thereof) which, individually or in the
          aggregate, represent a fundamental change in the information set forth
          in this Registration Statement; and

    (iii) to include any material information with respect to the plan of
          distribution not previously disclosed in this Registration Statement
          or any material change to such information in this Registration
          Statement;

     Provided, however, that paragraphs (1)(i) and (1)(ii) do not apply if the
information required to be included in a post effective amendment by these
paragraphs is contained in periodic reports filed by the Company pursuant to
Section 13 or Section 15(d) of the Securities Exchange Act of 1934 (the
"Exchange Act") that are incorporated by reference in this Registration
Statement.

    (b)   that, for the purposes of determining any liability under the
          Securities Act, each such post-effective amendment shall be deemed to
          be a new registration statement relating to the securities offered
          therein, and

                                       3
4

          the offering of such securities at that time shall be deemed to be the
          initial bona fide offering thereof;

    (c)   to remove from registration by means of a post-effective amendment any
          of the securities being registered which remain unsold at the
          termination of the offering;

    (d)   That,for purposes of determining any liability under the Securities
          Act, each filing of the Company's annual report pursuant to Section
          13(a) or 15(d) of the Exchange Act(and, where applicable, each filing
          of an employee benefits plan's annual report pursuant to Section 15(d)
          of the Exchange Act) that is incorporated by reference in the
          Registration Statement shall be deemed to be a new registration
          statement relating to the securities offered herein, and the offering
          of such securities at that time shall be deemed to be the initial bona
          fide offering thereof.

                                 SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Kinderhook, State of New York on November 11, 1999.

                                AMERICAN BIO MEDICA CORPORATION
                                     (Registrant)

                                    By: /s/Stan Cipkowski
                                        ------------------
                                        Stan Cipkowski,
                                        President, Chief Executive Officer, &
                                        Chairman of the Board of Directors

                                       4
5

                                POWER OF ATTORNEY

Each of the undersigned officers and directors of American Bio Medica
Corporation whose signature appears below hereby appoints Stan Cipkowski and
John F. Murray, and each of them, as true and lawful attorney-in-fact for the
undersigned with full power of substitution, to execute in his name and on his
behalf in each capacity stated below, any and all amendments (including
post-effective amendments) to this Registration Statement as the
attorney-in-fact shall deem appropriate, and to cause to be filed any such
amendment (including exhibits thereto and other documents in connection
therewith) to this Registration Statement with the Securities and Exchange
Commission, as fully and to all intents and purposes as such person might or
could do in person, hereby ratifying and confirming all that said
attorneys-in-fact, or any of them, may lawfully do or cause to be done by virtue
herewith.

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities indicated on November 11, 1999:

        Signature                           Title
        ---------                           -----

/s/Stan Cipkowski                 President, Chief Executive Officer,
---------------------             & Chairman of the Board of Directors
Stan Cipkowski                    (Principal Executive Officer)

/s/Edmund Jaskiewicz
---------------------             Director & Secretary
Edmund Jaskiewicz

/s/Jay Bendis                     Director & Vice President Sales &
---------------------             Marketing
Jay Bendis

/s/John F. Murray                 Director,Treasurer, Chief Financial Officer
---------------------             (Principal Financial Officer)
John F. Murray

---------------------
Gerald Moore                      Director

---------------------
Karen Russo                       Director

                                       5
6
                                                                       PAGE E-1

                               INDEX TO EXHIBITS

   Exhibit                         Description
   -------                         -----------

    3.07       Fifth Amendment to Certificate of Incorporation*

    5.01       Opinion and Consent of Hopkins & Sutter

    10.01      Fiscal 1998 Non-Statutory Stock Option Plan (filed as part of the
               Company's Proxy Statement for its Fiscal 1998 Annual Meeting and
               incorporated herein by reference)

    10.02      Fiscal 2000 Non-Statutory Stock Option Plan (filed as part of the
               Company's Proxy Statement for its Fiscal 2000 Annual Meeting and
               incorporated herein by reference)

    23.01      Consent of Richard A. Eisner & Company, LLP

    23.02      Consent of Hopkins & Sutter(contained in Exhibit 5.01)

-----------------------------

        *      Previously filed as an exhibit to Registration Statement on
               Form SB-2 filed on May 20, 1998 and incorporated herein by
               reference