<PAGE>   1

              As filed with the Securities and Exchange Commission
                              on December 14, 1999
                                                      Registration No. 333-_____
--------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                             POLYMEDICA CORPORATION
             (Exact name of registrant as specified in its charter)

              MASSACHUSETTS                             04-3033368
     (State or other jurisdiction of                 (I.R.S. Employer
      incorporation or organization)              Identification Number)

  11 STATE STREET, WOBURN, MASSACHUSETTS                  01801
 (Address of Principal Executive Offices)               (Zip Code)

                            1998 STOCK INCENTIVE PLAN
                            (Full title of the plan)

                            JOHN K.P. STONE III, ESQ.
                                HALE AND DORR LLP
                                 60 STATE STREET
                           BOSTON, MASSACHUSETTS 02109
                     (Name and address of agent for service)

                                 (617) 526-6000
          (Telephone number, including area code, of agent for service)

================================================================================

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
================================================================================================================
                                                  PROPOSED MAXIMUM         PROPOSED MAXIMUM         AMOUNT OF
 TITLE OF SECURITIES TO       AMOUNT TO BE       OFFERING PRICE PER       AGGREGATE OFFERING       REGISTRATION
      BE REGISTERED            REGISTERED              SHARE                    PRICE                  FEE
----------------------------------------------------------------------------------------------------------------

<S>                             <C>                   <C>                   <C>                      <C>
 Common Stock,
 $0.01 par value                200,000               $15.97(1)             $3,194,000.00(1)          $844.00
================================================================================================================
</TABLE>

(1)      Estimated solely for the purpose of calculating the registration fee,
         and based upon the average of the high and low prices of the Common
         Stock on the Nasdaq National Market on December 10, 1999 in accordance
         with Rules 457(c) and 457(h) of the Securities Act of 1933.
================================================================================


<PAGE>   2


                     Statement of Incorporation by Reference

                           ---------------------------


         This Registration Statement on Form S-8 incorporates by reference the
contents of Registration Statement on Form S-8, File No. 333-66685 filed by the
Registrant on November 2, 1998, relating to the Registrant's 1998 Stock
Incentive Plan.





                                       2
<PAGE>   3




                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Woburn, Massachusetts, on the 14th day of December,
1999.


                                         PolyMedica Corporation (registrant)



                                         By: /s/ Steven J. Lee
                                             ----------------------------------
                                             Steven J. Lee
                                             Chairman of the Board of Directors
                                             and Chief Executive Officer
                                             (Principal Executive Officer)




                                      II-1



<PAGE>   4


                                POWER OF ATTORNEY

         We, the undersigned officers and directors of PolyMedica Corporation,
hereby severally constitute Steven J. Lee, Eric G. Walters and John K.P. Stone
III, and each of them singly, our true and lawful attorneys with full power to
them, and each of them singly, to sign for us and in our names in the capacities
indicated below, the Registration Statement on Form S-8 filed herewith and any
and all subsequent amendments to said Registration Statement, and generally to
do all such things in our names and behalf in our capacities as officers and
directors to enable PolyMedica Corporation to comply with all requirements of
the Securities and Exchange Commission, hereby ratifying and confirming our
signatures as they may be signed by said attorneys, or any of them, to said
Registration Statement and any and all amendments thereto.

         Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed below by the following persons in the capacities and
on the date indicated.


       Signature                        Title                        Date
       ---------                        -----                        ----


                          Chairman of the Board of Directors   December 14, 1999
/s/ Steven J. Lee         and Chief Executive Officer
-----------------------   (Principal Executive Officer)
Steven J. Lee



                          Chief Financial Officer and Clerk    December 14, 1999
/s/ Eric G. Walters       (Principal Financial and
-----------------------   Accounting Officer)
Eric G. Walters



/s/ Thomas S. Soltys      Director                             December 14, 1999
-----------------------
Thomas S. Soltys



/s/ Daniel S. Bernstein   Director                             December 14, 1999
-----------------------
Daniel S. Bernstein



/s/ Frank W. Logerfo      Director                             December 14, 1999
-----------------------
Frank W. LoGerfo



/s/ Marcia J. Hooper      Director                             December 14, 1999
-----------------------
Marcia J. Hooper



/s/ Peter K. Hoffman      Director                             December 14, 1999
-----------------------
Peter K. Hoffman

                                      II-2

<PAGE>   5



                                  EXHIBIT INDEX



Exhibit
Number      Description
------      -----------

4.1         Restated Articles of Organization of the Registrant (1)

4.2         Restated By-Laws of the Registrant (1)

4.3         Specimen Certificate for shares of Common Stock, $.01 par value per
            share, of the Registrant (1)

5           Opinion of Hale and Dorr LLP

23.1        Consent of Hale and Dorr LLP (included in Exhibit 5)

23.2        Consent of PricewaterhouseCoopers LLP

24          Power of Attorney (included on the signature page of this
            Registration Statement)







-----------------------
(1)   Incorporated herein by reference to the exhibits to the Company's
      Registration Statement on Form S-1 (File No. 33-45425).
[{"type": "S-8", "sequence": "1", "description": "POLYMEDICA CORPORATION", "secsgml_size_bytes": 7527}]
{"company-data": {"conformed-name": "POLYMEDICA CORP", "cik": "0000878748", "assigned-sic": "2834", "irs-number": "043033368", "state-of-incorporation": "MA", "fiscal-year-end": "0331"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-92695", "film-number": "99774003"}, "business-address": {"street1": "11 STATE ST", "city": "WOBURN", "state": "MA", "zip": "01801", "phone": "6179332020"}, "mail-address": {"street1": "11 STATE STREET", "city": "WOBURN", "state": "MA", "zip": "01801"}, "former-company": {"former-conformed-name": "POLYMEDICA INDUSTRIES INC", "date-changed": "19930328"}}
1

              As filed with the Securities and Exchange Commission
                              on December 14, 1999
                                                      Registration No. 333-_____
--------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                             POLYMEDICA CORPORATION
             (Exact name of registrant as specified in its charter)

              MASSACHUSETTS                             04-3033368
     (State or other jurisdiction of                 (I.R.S. Employer
      incorporation or organization)              Identification Number)

  11 STATE STREET, WOBURN, MASSACHUSETTS                  01801
 (Address of Principal Executive Offices)               (Zip Code)

                            1998 STOCK INCENTIVE PLAN
                            (Full title of the plan)

                            JOHN K.P. STONE III, ESQ.
                                HALE AND DORR LLP
                                 60 STATE STREET
                           BOSTON, MASSACHUSETTS 02109
                     (Name and address of agent for service)

                                 (617) 526-6000
          (Telephone number, including area code, of agent for service)

================================================================================

                         CALCULATION OF REGISTRATION FEE
================================================================================================================
                                                  PROPOSED MAXIMUM         PROPOSED MAXIMUM         AMOUNT OF
 TITLE OF SECURITIES TO       AMOUNT TO BE       OFFERING PRICE PER       AGGREGATE OFFERING       REGISTRATION
      BE REGISTERED            REGISTERED              SHARE                    PRICE                  FEE
----------------------------------------------------------------------------------------------------------------
Common Stock,
 $0.01 par value                200,000               $15.97(1)             $3,194,000.00(1)          $844.00
================================================================================================================
(1)      Estimated solely for the purpose of calculating the registration fee,
         and based upon the average of the high and low prices of the Common
         Stock on the Nasdaq National Market on December 10, 1999 in accordance
         with Rules 457(c) and 457(h) of the Securities Act of 1933.
================================================================================
2

                     Statement of Incorporation by Reference

                           ---------------------------

         This Registration Statement on Form S-8 incorporates by reference the
contents of Registration Statement on Form S-8, File No. 333-66685 filed by the
Registrant on November 2, 1998, relating to the Registrant's 1998 Stock
Incentive Plan.

                                       2
3

                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Woburn, Massachusetts, on the 14th day of December,
1999.

                                         PolyMedica Corporation (registrant)

                                         By: /s/ Steven J. Lee
                                             ----------------------------------
                                             Steven J. Lee
                                             Chairman of the Board of Directors
                                             and Chief Executive Officer
                                             (Principal Executive Officer)

                                      II-1
4

                                POWER OF ATTORNEY

         We, the undersigned officers and directors of PolyMedica Corporation,
hereby severally constitute Steven J. Lee, Eric G. Walters and John K.P. Stone
III, and each of them singly, our true and lawful attorneys with full power to
them, and each of them singly, to sign for us and in our names in the capacities
indicated below, the Registration Statement on Form S-8 filed herewith and any
and all subsequent amendments to said Registration Statement, and generally to
do all such things in our names and behalf in our capacities as officers and
directors to enable PolyMedica Corporation to comply with all requirements of
the Securities and Exchange Commission, hereby ratifying and confirming our
signatures as they may be signed by said attorneys, or any of them, to said
Registration Statement and any and all amendments thereto.

         Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed below by the following persons in the capacities and
on the date indicated.

       Signature                        Title                        Date
       ---------                        -----                        ----

                          Chairman of the Board of Directors   December 14, 1999
/s/ Steven J. Lee         and Chief Executive Officer
-----------------------   (Principal Executive Officer)
Steven J. Lee

                          Chief Financial Officer and Clerk    December 14, 1999
/s/ Eric G. Walters       (Principal Financial and
-----------------------   Accounting Officer)
Eric G. Walters

/s/ Thomas S. Soltys      Director                             December 14, 1999
-----------------------
Thomas S. Soltys

/s/ Daniel S. Bernstein   Director                             December 14, 1999
-----------------------
Daniel S. Bernstein

/s/ Frank W. Logerfo      Director                             December 14, 1999
-----------------------
Frank W. LoGerfo

/s/ Marcia J. Hooper      Director                             December 14, 1999
-----------------------
Marcia J. Hooper

/s/ Peter K. Hoffman      Director                             December 14, 1999
-----------------------
Peter K. Hoffman

                                      II-2
5

                                  EXHIBIT INDEX

Exhibit
Number      Description
------      -----------

4.1         Restated Articles of Organization of the Registrant (1)

4.2         Restated By-Laws of the Registrant (1)

4.3         Specimen Certificate for shares of Common Stock, $.01 par value per
            share, of the Registrant (1)

5           Opinion of Hale and Dorr LLP

23.1        Consent of Hale and Dorr LLP (included in Exhibit 5)

23.2        Consent of PricewaterhouseCoopers LLP

24          Power of Attorney (included on the signature page of this
            Registration Statement)

-----------------------
(1)   Incorporated herein by reference to the exhibits to the Company's
      Registration Statement on Form S-1 (File No. 33-45425).