<HTML>
<HEAD>
<TITLE>INHIBITEX, INC.</TITLE>
</HEAD>
<BODY bgcolor="#FFFFFF">
<!-- PAGEBREAK -->
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>As filed with the Securities and Exchange Commission on October&nbsp;19, 2005</B></DIV>


<DIV align="right" style="font-size: 10pt; margin-top: 12pt"><B>Registration No.&nbsp;333-</B>
</DIV>

<DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
</DIV>
<P>
<DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
</DIV>

<DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>REGISTRATION STATEMENT</B></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>UNDER</B></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>THE SECURITIES ACT OF 1933</B></DIV>

<DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>INHIBITEX, INC.</B>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt">(Exact Name of Registrant as Specified in Its Charter)</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="48%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="48%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top"><B>Delaware</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>74-2708737</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">(State or Other Jurisdiction of Incorporation or Organization)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>9005 Westside Parkway<BR>
Alpharetta, GA 30004</B></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt">(Address of Principal Executive Offices including Zip Code)</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Amended and Restated 2004 Stock Incentive Plan</B></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt">(Full Title of the Plan)</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top"><B>WILLIAM D. JOHNSTON, PH.D.</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>Copy to:</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>President and Chief Executive Officer<BR>
Inhibitex, Inc.<BR>
9005 Westside Parkway<BR>
Alpharetta, GA 30004<BR>
(678)&nbsp;746-1100</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>DAVID S. ROSENTHAL, ESQ.<BR>
Dechert LLP<BR>
30 Rockefeller Plaza<BR>
New York, New York 10112<BR>
(212)&nbsp;698-3500</B></TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt">(Name and Address, Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service)</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CALCULATION OF REGISTRATION FEE</B>
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="1%">&nbsp;</TD>
    <TD width="42%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD><!-- VRule -->
    <TD width="2%">&nbsp;</TD>
    <TD width="11%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD><!-- VRule -->
    <TD width="2%">&nbsp;</TD>
    <TD width="11%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD><!-- VRule -->
    <TD width="2%">&nbsp;</TD>
    <TD width="11%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD><!-- VRule -->
    <TD width="2%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>

    <TD width="1%">&nbsp;</TD>
</TR><TR style="font-size: 1px" valign="bottom">
    <TD nowrap align="left" colspan="15" style="border-bottom: 3px double #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD>&nbsp;</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Amount</B></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Proposed Maximum</B></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Proposed Maximum</B></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Amount of</B></TD>
    <TD width="1%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD>&nbsp;</TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>to be</B></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Offering Price</B></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Aggregate Offering</B></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Registration</B></TD>
    <TD width="1%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD nowrap align="left"><B>Title of Each Class of Securities To Be Registered</B></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Registered (1)</B></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Per Share (2)</B></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Price (2)</B></TD>
    <TD style="border-right: 2px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Fee (2)</B></TD>
    <TD width="1%">&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
                    <TD valign="top" style="border-top: 2px solid #000000"><DIV style="margin-left:0px; text-indent:-0px">Common Stock, par value $.01 per share
</DIV></TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>

<TD align="left" valign="top" style="border-top: 2px solid #000000">1,500,000&nbsp;shares
</TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>

<TD align="center" valign="top" style="border-top: 2px solid #000000">$9.06
</TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>

<TD align="center" valign="top" style="border-top: 2px solid #000000">$13,590,000
</TD>
    <TD style="border-right: 2px solid #000000; border-top: 2px solid #000000">&nbsp;</TD>
    <TD style="border-top: 2px solid #000000">&nbsp;</TD>

<TD align="center" valign="top" style="border-top: 2px solid #000000">$1,599.54</TD>
    <TD width="1%" style="border-top: 2px solid #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 1px" valign="bottom">
    <TD nowrap align="left" colspan="15" style="border-top: 3px double #000000">&nbsp;</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Pursuant to Rule&nbsp;416 promulgated under the Securities Act of 1933,
as amended (the &#147;Act&#148;), this Registration Statement also covers
such additional securities as may become issuable to prevent
dilution resulting from stock splits, stock dividends and similar
transactions.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Estimated solely for the purpose of calculating the registration fee
pursuant to Rule 457(h) and (c)&nbsp;under the Act on the basis of
$9.06
per share, the average of the high and low prices of the Common Stock
as quoted on the Nasdaq National Market on October&nbsp;12, 2005).
</TD>
</TR>
</TABLE>
</DIV>
<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">


</TABLE>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Statement Under General Instruction E</B>
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Registration of Additional Securities</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">This Registration Statement on Form S-8 is being filed for the purpose of registering an
additional 1,500,000 shares of common stock, par value $.001 per share (the &#147;Common Stock&#148;), of
Inhibitex, Inc., a Delaware corporation (the &#147;Registrant&#148;), to be issued pursuant to the
Registrant&#146;s Amended and Restated 2004 Stock Incentive Plan (the &#147;2004 Plan&#148;).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to General Instruction E to Form S-8, the Registrant&#146;s Registration Statement on Form S-8
previously filed with the Securities and Exchange Commission (the &#147;Commission&#148;) relating to the
2004 Plan (No.&nbsp;333-116446) is incorporated herein by reference.
</DIV>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II</B>
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;8. Exhibits.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following exhibits are filed as part of this registration statement.
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">4.1</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Amended and Restated 2004 Stock Incentive Plan (incorporated by
reference to Exhibit&nbsp;99.1 to the Current Report on Form 8-K filed
with the Securities and Exchange Commission on May&nbsp;18, 2005).</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">4.2</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Form of Stock Option Agreement under the 2004 Stock Incentive Plan
(incorporated by reference to Exhibit&nbsp;10.2.1 to the Post-Effective
Amendment on Form S-3 to the Registration Statement on Form S-1,
filed with the Securities and Exchange Commission on June&nbsp;27, 2005).</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">5.1</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Opinion of Dechert LLP.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">23.1</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Consent of Ernst &#038; Young LLP.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">23.2</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Consent of Dechert LLP (included in Exhibit&nbsp;5.1).</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">24.1</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Powers of Attorney (included on signature page).</TD>
</TR>

</TABLE>
</DIV>
<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">



</TABLE>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has
reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Alpharetta, State of Georgia, on October&nbsp;19, 2005.
</DIV>


<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">INHIBITEX, INC.<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ William D. Johnston, Ph. D.&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">William D. Johnston, Ph. D.&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left"><I>President and Chief Executive Officer</I>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">KNOW ALL MEN BY THESE PRESENTS, that each of the undersigned whose signature appears below
constitutes and appoints William D. Johnston and Russell H. Plumb, his or her true and lawful
attorneys-in-fact, with full power of substitution and resubstitution for him or her and on his or
her behalf, and in his or her name, place and stead, in any and all capacities to execute and sign
any and all amendments or post-effective amendments to this registration statement, and to file the
same, with all exhibits thereto, and other documents in connection therewith, with the Securities
and Exchange Commission, hereby ratifying and confirming all that said attorneys-in-fact or any of
them or their or his substitute or substitutes, may lawfully do or cause to be done by virtue
hereof and the Company hereby confers like authority on its behalf.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been
signed below by the following persons in the capacity and on the dates indicated.
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="25%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="37%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="28%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10 pt; border-bottom: 1px solid #000000">/s/ William D. Johnston, Ph. D.&nbsp;</DIV>
William D. Johnston, Ph. D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
President and Chief Executive Officer, Director
(Principal Executive Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October 19, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10 pt; border-bottom: 1px solid #000000">/s/ Russell H. Plumb&nbsp;</DIV>
Russell H. Plumb</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Vice President, Finance and Administration and
Chief Financial Office (Principal Financial Officer
and Principal Accounting Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October 19, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10 pt; border-bottom: 1px solid #000000">/s/ Michael A. Henos&nbsp;</DIV>
Michael A. Henos</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Chairman of the Board of Directors
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October 19, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10 pt; border-bottom: 1px solid #000000">/s/ M. James Barrett, Ph.D.&nbsp;</DIV>
M. James Barrett, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October 19, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10 pt; border-bottom: 1px solid #000000">/s/ Carl E. Brooks&nbsp;</DIV>
Carl E. Brooks</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October 19, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10 pt; border-bottom: 1px solid #000000">/s/ Robert A. Hamm&nbsp;</DIV>
Robert A. Hamm</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October  19, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10 pt; border-bottom: 1px solid #000000">/s/ Russell M. Medford, M.D., Ph.D.&nbsp;</DIV>
Russell M. Medford, M.D., Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October 19, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10 pt; border-bottom: 1px solid #000000">/s/ Joseph M. Patti, M.S.P.H., Ph.D.&nbsp;</DIV>
Joseph M. Patti, M.S.P.H., Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October 19, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10 pt; border-bottom: 1px solid #000000">/s/ Marc L. Preminger&nbsp;</DIV>
Marc L. Preminger</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October 19, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10 pt; border-bottom: 1px solid #000000">/s/ Louis W. Sullivan, M.D.&nbsp;</DIV>
Louis W. Sullivan, M.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October 19, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">&nbsp;<BR>
<DIV style="font-size: 10pt; border-bottom: 1px solid #000000">/s/ A. Keith Willard&nbsp;</DIV>
A. Keith Willard</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">October 19, 2005</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "g97731sv8.htm", "description": "INHIBITEX, INC.", "secsgml_size_bytes": 21762}]
{"company-data": {"conformed-name": "INHIBITEX INC", "cik": "0001274913", "assigned-sic": "2836", "irs-number": "742708737"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-129122", "film-number": "051145380"}, "business-address": {"street1": "8997 WESTLAKE PARKWAY", "city": "ALPHARETTA", "state": "GA", "zip": "30004", "phone": "678-746-1100"}, "mail-address": {"street1": "8997 WESTLAKE PARKWAY", "city": "ALPHARETTA", "state": "GA", "zip": "30004"}}
INHIBITEX, INC.
As filed with the Securities and Exchange Commission on October 19, 2005
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
INHIBITEX, INC.
(Exact Name of Registrant as Specified in Its Charter)
Delaware
74-2708737
(State or Other Jurisdiction of Incorporation or Organization)
(I.R.S. Employer Identification No.)
9005 Westside Parkway
Alpharetta, GA 30004
(Address of Principal Executive Offices including Zip Code)
Amended and Restated 2004 Stock Incentive Plan
(Full Title of the Plan)
WILLIAM D. JOHNSTON, PH.D.
Copy to:
President and Chief Executive Officer
Inhibitex, Inc.
9005 Westside Parkway
Alpharetta, GA 30004
(678) 746-1100
DAVID S. ROSENTHAL, ESQ.
Dechert LLP
30 Rockefeller Plaza
New York, New York 10112
(212) 698-3500
(Name and Address, Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service)
CALCULATION OF REGISTRATION FEE
Amount
Proposed Maximum
Proposed Maximum
Amount of
to be
Offering Price
Aggregate Offering
Registration
Title of Each Class of Securities To Be Registered
Registered (1)
Per Share (2)
Price (2)
Fee (2)
Common Stock, par value $.01 per share
1,500,000 shares
$9.06
$13,590,000
$1,599.54
(1)
Pursuant to Rule 416 promulgated under the Securities Act of 1933,
as amended (the "Act"), this Registration Statement also covers
such additional securities as may become issuable to prevent
dilution resulting from stock splits, stock dividends and similar
transactions.
(2)
Estimated solely for the purpose of calculating the registration fee
pursuant to Rule 457(h) and (c) under the Act on the basis of
$9.06
per share, the average of the high and low prices of the Common Stock
as quoted on the Nasdaq National Market on October 12, 2005).
Statement Under General Instruction E
Registration of Additional Securities
This Registration Statement on Form S-8 is being filed for the purpose of registering an
additional 1,500,000 shares of common stock, par value $.001 per share (the "Common Stock"), of
Inhibitex, Inc., a Delaware corporation (the "Registrant"), to be issued pursuant to the
Registrant's Amended and Restated 2004 Stock Incentive Plan (the "2004 Plan").
Pursuant to General Instruction E to Form S-8, the Registrant's Registration Statement on Form S-8
previously filed with the Securities and Exchange Commission (the "Commission") relating to the
2004 Plan (No. 333-116446) is incorporated herein by reference.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 8. Exhibits.
The following exhibits are filed as part of this registration statement.
4.1
Amended and Restated 2004 Stock Incentive Plan (incorporated by
reference to Exhibit 99.1 to the Current Report on Form 8-K filed
with the Securities and Exchange Commission on May 18, 2005).
4.2
Form of Stock Option Agreement under the 2004 Stock Incentive Plan
(incorporated by reference to Exhibit 10.2.1 to the Post-Effective
Amendment on Form S-3 to the Registration Statement on Form S-1,
filed with the Securities and Exchange Commission on June 27, 2005).
5.1
Opinion of Dechert LLP.
23.1
Consent of Ernst & Young LLP.
23.2
Consent of Dechert LLP (included in Exhibit 5.1).
24.1
Powers of Attorney (included on signature page).
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has
reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Alpharetta, State of Georgia, on October 19, 2005.
INHIBITEX, INC.
By:
/s/ William D. Johnston, Ph. D.
William D. Johnston, Ph. D.
President and Chief Executive Officer
KNOW ALL MEN BY THESE PRESENTS, that each of the undersigned whose signature appears below
constitutes and appoints William D. Johnston and Russell H. Plumb, his or her true and lawful
attorneys-in-fact, with full power of substitution and resubstitution for him or her and on his or
her behalf, and in his or her name, place and stead, in any and all capacities to execute and sign
any and all amendments or post-effective amendments to this registration statement, and to file the
same, with all exhibits thereto, and other documents in connection therewith, with the Securities
and Exchange Commission, hereby ratifying and confirming all that said attorneys-in-fact or any of
them or their or his substitute or substitutes, may lawfully do or cause to be done by virtue
hereof and the Company hereby confers like authority on its behalf.
Pursuant to the requirements of the Securities Act of 1933, this registration statement has been
signed below by the following persons in the capacity and on the dates indicated.
/s/ William D. Johnston, Ph. D.
William D. Johnston, Ph. D.
President and Chief Executive Officer, Director
(Principal Executive Officer)
October 19, 2005
/s/ Russell H. Plumb
Russell H. Plumb
Vice President, Finance and Administration and
Chief Financial Office (Principal Financial Officer
and Principal Accounting Officer)
October 19, 2005
/s/ Michael A. Henos
Michael A. Henos
Chairman of the Board of Directors
October 19, 2005
/s/ M. James Barrett, Ph.D.
M. James Barrett, Ph.D.
Director
October 19, 2005
/s/ Carl E. Brooks
Carl E. Brooks
Director
October 19, 2005
/s/ Robert A. Hamm
Robert A. Hamm
Director
October  19, 2005
/s/ Russell M. Medford, M.D., Ph.D.
Russell M. Medford, M.D., Ph.D.
Director
October 19, 2005
/s/ Joseph M. Patti, M.S.P.H., Ph.D.
Joseph M. Patti, M.S.P.H., Ph.D.
Director
October 19, 2005
/s/ Marc L. Preminger
Marc L. Preminger
Director
October 19, 2005
/s/ Louis W. Sullivan, M.D.
Louis W. Sullivan, M.D.
Director
October 19, 2005
/s/ A. Keith Willard
A. Keith Willard
Director
October 19, 2005