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<P align="center"><FONT size="2">As filed with the Securities and Exchange Commission on May&nbsp;30, 2002<BR>
Registration No.&nbsp;333- <u>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u>
</FONT>
<P align="center"><FONT size="2">SECURITIES AND EXCHANGE COMMISSION<BR>
WASHINGTON, D.C. 20549
</FONT>
<P align="center"><FONT size="2"><B>FORM S-8</B>
</FONT>
<P align="center"><FONT size="2">REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933
</FONT>
<P align="center"><FONT size="2"><B>HUMAN GENOME SCIENCES, INC.</B><BR>
(Exact name of registrant as specified in its charter)
</FONT>
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<TABLE cellspacing="0" border="0" cellpadding="0" width="65%">
<TR valign="bottom">
        <TD width="51%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="44%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2"><B>Delaware</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>22-3178468</B></FONT></TD>
</TR>

<TR valign="bottom">
        <TD align="center" valign="top" nowrap><FONT size="2">(State or other jurisdiction of</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
(I.R.S. Employer Identification No.)</FONT></TD>
</TR>

<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2">incorporation or organization)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>
</TABLE>
</CENTER>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="55%">
<TR valign="bottom">
        <TD width="50%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="45%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2"><B>9410 Key West Avenue</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2"><B>Rockville, Maryland</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>20850-3338</B></FONT></TD>
</TR>

<TR valign="bottom">
        <TD align="center" valign="top" nowrap><FONT size="2">(Address of principal executive offices)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
(Zip Code)</FONT></TD>
</TR>
</TABLE>
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<P align="center"><FONT size="2"><B>HUMAN GENOME SCIENCES, INC. AMENDED AND RESTATED 2000 STOCK INCENTIVE PLAN</B><BR>
(Full title of plan)
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<TABLE cellspacing="0" border="0" cellpadding="0" width="65%">
<TR valign="bottom">
        <TD width="50%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="45%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2">(Name, address and telephone</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2">number of agent for service)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
(Copy to:)</FONT></TD>
</TR>

<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2"><B>William A. Haseltine, Ph.D.</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>R.W. Smith, Jr., Esquire</B></FONT></TD>
</TR>

<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2"><B>Human Genome Sciences, Inc.</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>Piper Rudnick LLP</B></FONT></TD>
</TR>

<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2"><B>9410 Key West Avenue</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>6225 Smith Avenue</B></FONT></TD>
</TR>

<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2"><B>Rockville, Maryland 20850-3338</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>Baltimore, Maryland 21209-3600</B></FONT></TD>
</TR>

<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2"><B>(301)&nbsp;309-8504</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>(410)&nbsp;580-3000</B></FONT></TD>
</TR>
</TABLE>
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<P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B>
</FONT>

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<TABLE cellspacing="0" border="0" cellpadding="0" width="90%">
<TR valign="bottom">
        <TD width="41%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="6%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="7%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="4%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="6%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="7%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Maximum</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Maximum</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>to be</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1"><B>Title of Securities to be Registered</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registered</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Price Per Unit</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Fee</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD colspan="3"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD colspan="3"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD colspan="3"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD colspan="3"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom" bgcolor="#eeeeee">
        <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock, par value $0.01 per share (1)</FONT></DIV></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="right"><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">6,413,920</FONT></TD>
        <TD nowrap><FONT size="2">(2)(3)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">16.775</FONT></TD>
        <TD nowrap><FONT size="2">(4)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">107,593,508</FONT></TD>
        <TD nowrap><FONT size="2">(4)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">9,898.60</FONT></TD>
        <TD nowrap><FONT size="2">(4)</FONT></TD>
</TR>
<TR>
        <TD><DIV style="margin-left:10px; text-indent:-10px"><HR size="4" noshade></DIV></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><HR size="4" noshade></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><HR size="4" noshade></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><HR size="4" noshade></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><HR size="4" noshade></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
        <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Includes rights (&#147;Rights&#148;) to purchase shares of the Registrant&#146;s junior
participating preferred stock, issuable pursuant to that certain Rights
Agreement between the Registrant and American Stock Transfer &#038; Trust
Company, as Rights Agent, dated as of May&nbsp;20, 1998. The value
attributable to the Rights, if any, is reflected in the market price of
the Common Stock.</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
        <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">The shares of Common Stock of the Registrant (the &#147;Common Stock&#148;)
registered on this Registration Statement are in addition to shares of
Common Stock registered on Forms S-8 filed on August&nbsp;30, 2000 (file number
333-44798) and August&nbsp;3, 2001 (file number 333-66670).</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
        <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Pursuant to Rule&nbsp;416(a) under the Securities Act of 1933, as amended,
this Registration Statement also covers an indeterminate number of shares
of Common Stock that may be offered or issued pursuant to the Amended and
Restated 2000 Stock Incentive Plan by reason of stock splits, stock
dividends or similar transactions.</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
        <TD width="1%" align="left" nowrap><FONT size="2">(4)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Estimated solely for the purposes of calculating the registration fee
under Rule&nbsp;457(c) and (h). The proposed maximum offering price per share,
proposed maximum aggregate offering price and the amount of the
registration fee are based on the average of the daily high and low sale
prices of the Common Stock on the NASDAQ National Market system on May&nbsp;23,
2002 (i.e., $16.775).</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">&nbsp;</FONT>
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<P align="center"><FONT size="2">INCORPORATION BY REFERENCE
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to General Instruction E to Form&nbsp;S-8, the contents of the
Registration Statements filed on Forms S-8 by Human Genome Sciences, Inc. (the
&#147;Registrant&#148;) on August&nbsp;30, 2000 (file number 333-44798) and August&nbsp;3, 2001
(file number 333-66670) with respect to securities offered pursuant to the
Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive Plan are
incorporated by reference herein.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In addition, the following documents filed by the Registrant with the
Securities and Exchange Commission (the &#147;Commission&#148;) pursuant to the
Securities Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;), are
incorporated herein by reference:
</FONT>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="1%" align="left" nowrap><FONT size="2">(a)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="93%"><FONT size="2">The Registrant&#146;s Annual Report on Form&nbsp;10-K for the year
ended December&nbsp;31, 2001;</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="1%" align="left" nowrap><FONT size="2">(b)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="93%"><FONT size="2">All other reports filed pursuant to Sections&nbsp;13(a) or 15(d)
of the Exchange Act since December&nbsp;31, 2001; and</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="1%" align="left" nowrap><FONT size="2">(c)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="93%"><FONT size="2">The description of Common Stock of the Registrant contained
or incorporated in the registration statements filed by the
Registrant under the Exchange Act, including any amendments or
reports filed for the purpose of updating such description.</FONT></TD>
</TR>
</TABLE>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents subsequently filed by the Registrant with the Commission
pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to
the filing of a post-effective amendment which indicates that all securities
offered have been sold or which deregisters all securities remaining unsold,
shall be deemed to be incorporated by reference into this Registration
Statement and to be a part of this Registration Statement from the date of
filing of such documents.
</FONT>
<P><FONT size="2">ITEM 8. EXHIBITS.
</FONT>

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<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="8%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="87%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="left"><FONT size="1">EXHIBIT</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="left"><FONT size="1">NUMBER</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="1">DESCRIPTION</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR width=12% align=left size="1" noshade></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Certificate of Incorporation of the Registrant (filed as Exhibit&nbsp;3.1 of
the Registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended December
31, 1993, Exhibit&nbsp;3.3 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for
the year ended December&nbsp;31, 1997, as Exhibit&nbsp;3.1 to the Registrant&#146;s
Current Report on Form&nbsp;8-K filed on December&nbsp;16, 1999, and Exhibit&nbsp;3.1 to
the Registrant&#146;s Quarterly Report on Form&nbsp;10-Q for the quarter ended June
30, 2001, and incorporated herein by reference)<BR>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
By-Laws of the Registrant (filed as Exhibit&nbsp;3.2 to the Registrant&#146;s
Quarterly Report on Form&nbsp;10-Q for the quarter ended June&nbsp;30, 2000, and
incorporated herein by reference)<BR>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.3</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Rights Agreement between the Registrant and American Stock Transfer &
Trust Company, as Rights Agent, dated as of May&nbsp;20, 1998 (filed as Exhibit
4 of the Registrant&#146;s Current Report on Form&nbsp;8-K filed on May&nbsp;28, 1998,
and incorporated herein by reference).<BR>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.4</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Indenture dated as of June&nbsp;25, 1999 between the Registrant and The Bank
of New York, as trustee, including the form of 5-1/2% Convertible
Subordinated Notes due 2006 (filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Form
8-K filed June&nbsp;28, 1999)<BR>&nbsp;</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>
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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="8%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="87%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.5</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Indenture dated as of February&nbsp;1, 2000 between the Registrant and The
Bank of New York, as trustee, including the form of 5% Convertible
Subordinated Notes due 2007 (filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Form
8-K filed February&nbsp;2, 2000)<BR>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.6</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Indenture dated as of March&nbsp;10, 2000 between the Registrant and The Bank
of New York, as trustee, including the form of 3-3/4% Convertible
Subordinated Notes due 2007 (filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Form
8-K filed March&nbsp;13, 2000)<BR>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.7</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive
Plan (filed as Exhibit&nbsp;A of the Registrant&#146;s Definitive Proxy Statement on
Schedule&nbsp;14A, filed April&nbsp;18, 2001, and incorporated herein by reference).<BR>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">5.1*</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Opinion of Piper Rudnick LLP, counsel for the Registrant, regarding the
legal validity of the shares of Common Stock being registered under this
Registration Statement<BR>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.1*</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Piper Rudnick LLP, counsel for the Registrant (contained in
Exhibit&nbsp;5.1)<BR>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.2*</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, Independent Auditors<BR>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">24.1*</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Power of Attorney (included on Signature Page)</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P>
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<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">*</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Filed herewith.</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">&nbsp;</FONT>
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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>




<P align="center"><FONT size="2">SIGNATURES
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form&nbsp;S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Rockville, State of Maryland, on the 30th day
of May, 2002.
</FONT>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="30%">
<TR valign="bottom">
        <TD width="10%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="85%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD colspan=3 align="left" valign="top"><FONT size="2">
HUMAN GENOME SCIENCES, INC.</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">By:</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
/s/ William A. Haseltine, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
William A. Haseltine, Ph.D.<BR>
Chairman of the Board and<BR>
Chief Executive Officer</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>
<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>





<P align="center"><FONT size="2">POWERS OF ATTORNEY
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL MEN BY THESE PRESENTS, that the undersigned officers and
Directors of Human Genome Sciences, Inc., a Delaware corporation (the
&#147;Corporation&#148;), hereby constitute and appoint William A. Haseltine, Ph.D., and
Craig A. Rosen, Ph.D., and each of them, the true and lawful agents and
attorneys-in-fact of the undersigned with full power and authority in said
agents and attorneys-in-fact, and in either or both of them, to sign for the
undersigned and in their respective names as officers and as Directors of the
Corporation, a Registration Statement on Form&nbsp;S-8 (or other appropriate form)
(the &#147;Registration Statement&#148;) relating to the proposed issuance of Common
Stock, par value $0.01 per share, of the Corporation pursuant to the exercise
of stock options and other awards granted under the Human Genome Sciences, Inc.
Amended and Restated 2000 Stock Incentive Plan (or any and all amendments,
including post-effective amendments, to such Registration Statement) and file
the same, with all exhibits thereto and other documents in connection
therewith, with the Securities and Exchange Commission, and with full power of
substitution, hereby ratifying and confirming all that each of said
attorneys-in-fact, or his substitute or substitutes, may do or cause to be done
by virtue hereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the date indicated.
</FONT>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="85%">
<TR valign="bottom">
        <TD width="40%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="45%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="9%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR>
<TD>&nbsp;
</TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ William A. Haseltine, Ph.D.
<HR size="1" noshade>
William A. Haseltine, Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Chairman of the Board and<BR>
Chief Executive Officer<BR>
(principal executive officer)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" nowrap valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2"><BR>&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Craig A. Rosen, Ph.D.
<HR size="1" noshade>
Craig A. Rosen, Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Executive Vice President, Research
and Development and Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2"><BR>&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Steven C. Mayer
<HR size="1" noshade>
Steven C. Mayer</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Senior Vice President and<BR>
Chief Financial Officer<BR>
(principal financial and accounting officer)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2"><BR>&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Richard J. Danzig
<HR size="1" noshade>
Richard J. Danzig</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>
<tr><td>&nbsp;</td></tr>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">
<HR size="1" noshade>
Jurgen Drews, M.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>
<tr><td>&nbsp;</td></tr>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">
<HR size="1" noshade>
Richard C. Holbrooke</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2"><BR>&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Robert Hormats
<HR size="1" noshade>
Robert Hormats</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2"><BR>&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Argeris (Jerry) N. Karabelas, Ph.D.
<HR size="1" noshade>
Argeris (Jerry) N. Karabelas, Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2"><BR>&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Max Link, Ph.D.
<HR size="1" noshade>
Max Link, Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2"><BR>&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Alan G. Spoon
<HR size="1" noshade>
Alan G. Spoon</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2"><BR>&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Laura D&#146;Andrea Tyson, Ph.D.
<HR size="1" noshade>
Laura D&#146;Andrea Tyson, Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2"><BR>&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ James Barnes Wyngaarden, M.D.
<HR size="1" noshade>
James Barnes Wyngaarden, M.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">May&nbsp;30, 2002</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>
<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
<P align="left"><FONT size="2">EXHIBIT INDEX
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="6%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="91%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="left"><FONT size="1">EXHIBIT</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="left"><FONT size="1">NUMBER</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="1">DESCRIPTION</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR width=12% align=left size="1" noshade></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Certificate of Incorporation of the Registrant (filed as Exhibit&nbsp;3.1 of
the Registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended December
31, 1993, Exhibit&nbsp;3.3 to the Registrant&#146;s Annual Report on Form&nbsp;10-K for
the year ended December&nbsp;31, 1997, as Exhibit&nbsp;3.1 to the Registrant&#146;s
Current Report on Form&nbsp;8-K filed on December&nbsp;16, 1999, and Exhibit&nbsp;3.1 to
the Registrant&#146;s Quarterly Report on Form&nbsp;10-Q for the quarter ended June
30, 2001, and incorporated herein by reference)<br>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
By-Laws of the Registrant (filed as Exhibit&nbsp;3.2 to the Registrant&#146;s
Quarterly Report on Form&nbsp;10-Q for the quarter ended June&nbsp;30, 2000, and
incorporated herein by reference)<br>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.3</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Rights Agreement between the Registrant and American Stock Transfer &
Trust Company, as Rights Agent, dated as of May&nbsp;20, 1998 (filed as Exhibit
4 of the Registrant&#146;s Current Report on Form&nbsp;8-K filed on may 28, 1998,
and incorporated herein by reference).<br>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.4</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Indenture dated as of June&nbsp;25, 1999 between the Registrant and The Bank
of New York, as trustee, including the form of 5-1/2% Convertible
Subordinated Notes due 2006 (filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Form
8 -K filed June&nbsp;28, 1999)<br>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.5</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Indenture dated as of February&nbsp;1, 2000 between the Registrant and The
Bank of New York, as trustee, including the form of 5% Convertible
Subordinated Notes due 2007 (filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Form
8-K filed February&nbsp;2, 2000)<br>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.6</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Indenture dated as of March&nbsp;10, 2000 between the Registrant and The Bank
of New York, as trustee, including the form of 3-3/4% Convertible
Subordinated Notes due 2007 (filed as Exhibit&nbsp;4.1 to the Registrant&#146;s Form
8-K filed March&nbsp;13, 2000)<br>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.7</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive
Plan (filed as Exhibit&nbsp;A of the Registrant&#146;s Definitive Proxy Statement on
Schedule&nbsp;14A, filed April&nbsp;18, 2001, and incorporated herein by reference).<br>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">5.1*</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Opinion of Piper Rudnick LLP, counsel for the Registrant, regarding the
legal validity of the shares of Common Stock being registered under this
Registration Statement<br>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.1*</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Piper Rudnick LLP, counsel for the Registrant (contained in Exhibit&nbsp;5.1)<br>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.2*</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, Independent Auditors<br>&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">24.1*</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Power of Attorney (included on Signature Page)<br>&nbsp;</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P>
<HR size="1" width="18%" align="left" noshade>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">*</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Filed herewith.</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">&nbsp;</FONT>




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sv8
As filed with the Securities and Exchange Commission on May 30, 2002
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
HUMAN GENOME SCIENCES, INC.
(Exact name of registrant as specified in its charter)
Delaware
22-3178468
(State or other jurisdiction of
(I.R.S. Employer Identification No.)
incorporation or organization)
9410 Key West Avenue
Rockville, Maryland
20850-3338
(Address of principal executive offices)
(Zip Code)
HUMAN GENOME SCIENCES, INC. AMENDED AND RESTATED 2000 STOCK INCENTIVE PLAN
(Full title of plan)
(Name, address and telephone
number of agent for service)
(Copy to:)
William A. Haseltine, Ph.D.
R.W. Smith, Jr., Esquire
Human Genome Sciences, Inc.
Piper Rudnick LLP
9410 Key West Avenue
6225 Smith Avenue
Rockville, Maryland 20850-3338
Baltimore, Maryland 21209-3600
(301) 309-8504
(410) 580-3000
CALCULATION OF REGISTRATION FEE
Proposed
Proposed
Amount
Maximum
Maximum
Amount of
to be
Offering
Aggregate
Registration
Title of Securities to be Registered
Registered
Price Per Unit
Offering Price
Fee
Common Stock, par value $0.01 per share (1)
6,413,920
(2)(3)
$
16.775
(4)
$
107,593,508
(4)
$
9,898.60
(4)
(1)
Includes rights ("Rights") to purchase shares of the Registrant's junior
participating preferred stock, issuable pursuant to that certain Rights
Agreement between the Registrant and American Stock Transfer & Trust
Company, as Rights Agent, dated as of May 20, 1998. The value
attributable to the Rights, if any, is reflected in the market price of
the Common Stock.
(2)
The shares of Common Stock of the Registrant (the "Common Stock")
registered on this Registration Statement are in addition to shares of
Common Stock registered on Forms S-8 filed on August 30, 2000 (file number
333-44798) and August 3, 2001 (file number 333-66670).
(3)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended,
this Registration Statement also covers an indeterminate number of shares
of Common Stock that may be offered or issued pursuant to the Amended and
Restated 2000 Stock Incentive Plan by reason of stock splits, stock
dividends or similar transactions.
(4)
Estimated solely for the purposes of calculating the registration fee
under Rule 457(c) and (h). The proposed maximum offering price per share,
proposed maximum aggregate offering price and the amount of the
registration fee are based on the average of the daily high and low sale
prices of the Common Stock on the NASDAQ National Market system on May 23,
2002 (i.e., $16.775).
INCORPORATION BY REFERENCE
Pursuant to General Instruction E to Form S-8, the contents of the
Registration Statements filed on Forms S-8 by Human Genome Sciences, Inc. (the
"Registrant") on August 30, 2000 (file number 333-44798) and August 3, 2001
(file number 333-66670) with respect to securities offered pursuant to the
Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive Plan are
incorporated by reference herein.
In addition, the following documents filed by the Registrant with the
Securities and Exchange Commission (the "Commission") pursuant to the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), are
incorporated herein by reference:
(a)
The Registrant's Annual Report on Form 10-K for the year
ended December 31, 2001;
(b)
All other reports filed pursuant to Sections 13(a) or 15(d)
of the Exchange Act since December 31, 2001; and
(c)
The description of Common Stock of the Registrant contained
or incorporated in the registration statements filed by the
Registrant under the Exchange Act, including any amendments or
reports filed for the purpose of updating such description.
All documents subsequently filed by the Registrant with the Commission
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to
the filing of a post-effective amendment which indicates that all securities
offered have been sold or which deregisters all securities remaining unsold,
shall be deemed to be incorporated by reference into this Registration
Statement and to be a part of this Registration Statement from the date of
filing of such documents.
ITEM 8. EXHIBITS.
EXHIBIT
NUMBER
DESCRIPTION
4.1
Certificate of Incorporation of the Registrant (filed as Exhibit 3.1 of
the Registrant's Annual Report on Form 10-K for the year ended December
31, 1993, Exhibit 3.3 to the Registrant's Annual Report on Form 10-K for
the year ended December 31, 1997, as Exhibit 3.1 to the Registrant's
Current Report on Form 8-K filed on December 16, 1999, and Exhibit 3.1 to
the Registrant's Quarterly Report on Form 10-Q for the quarter ended June
30, 2001, and incorporated herein by reference)
4.2
By-Laws of the Registrant (filed as Exhibit 3.2 to the Registrant's
Quarterly Report on Form 10-Q for the quarter ended June 30, 2000, and
incorporated herein by reference)
4.3
Rights Agreement between the Registrant and American Stock Transfer &
Trust Company, as Rights Agent, dated as of May 20, 1998 (filed as Exhibit
4 of the Registrant's Current Report on Form 8-K filed on May 28, 1998,
and incorporated herein by reference).
4.4
Indenture dated as of June 25, 1999 between the Registrant and The Bank
of New York, as trustee, including the form of 5-1/2% Convertible
Subordinated Notes due 2006 (filed as Exhibit 4.1 to the Registrant's Form
8-K filed June 28, 1999)
4.5
Indenture dated as of February 1, 2000 between the Registrant and The
Bank of New York, as trustee, including the form of 5% Convertible
Subordinated Notes due 2007 (filed as Exhibit 4.1 to the Registrant's Form
8-K filed February 2, 2000)
4.6
Indenture dated as of March 10, 2000 between the Registrant and The Bank
of New York, as trustee, including the form of 3-3/4% Convertible
Subordinated Notes due 2007 (filed as Exhibit 4.1 to the Registrant's Form
8-K filed March 13, 2000)
4.7
Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive
Plan (filed as Exhibit A of the Registrant's Definitive Proxy Statement on
Schedule 14A, filed April 18, 2001, and incorporated herein by reference).
5.1*
Opinion of Piper Rudnick LLP, counsel for the Registrant, regarding the
legal validity of the shares of Common Stock being registered under this
Registration Statement
23.1*
Consent of Piper Rudnick LLP, counsel for the Registrant (contained in
Exhibit 5.1)
23.2*
Consent of Ernst & Young LLP, Independent Auditors
24.1*
Power of Attorney (included on Signature Page)
*
Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Rockville, State of Maryland, on the 30th day
of May, 2002.
HUMAN GENOME SCIENCES, INC.
By:
/s/ William A. Haseltine, Ph.D.
William A. Haseltine, Ph.D.
Chairman of the Board and
Chief Executive Officer
POWERS OF ATTORNEY
KNOW ALL MEN BY THESE PRESENTS, that the undersigned officers and
Directors of Human Genome Sciences, Inc., a Delaware corporation (the
"Corporation"), hereby constitute and appoint William A. Haseltine, Ph.D., and
Craig A. Rosen, Ph.D., and each of them, the true and lawful agents and
attorneys-in-fact of the undersigned with full power and authority in said
agents and attorneys-in-fact, and in either or both of them, to sign for the
undersigned and in their respective names as officers and as Directors of the
Corporation, a Registration Statement on Form S-8 (or other appropriate form)
(the "Registration Statement") relating to the proposed issuance of Common
Stock, par value $0.01 per share, of the Corporation pursuant to the exercise
of stock options and other awards granted under the Human Genome Sciences, Inc.
Amended and Restated 2000 Stock Incentive Plan (or any and all amendments,
including post-effective amendments, to such Registration Statement) and file
the same, with all exhibits thereto and other documents in connection
therewith, with the Securities and Exchange Commission, and with full power of
substitution, hereby ratifying and confirming all that each of said
attorneys-in-fact, or his substitute or substitutes, may do or cause to be done
by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the date indicated.
Signature
Title
Date
/s/ William A. Haseltine, Ph.D.
William A. Haseltine, Ph.D.
Chairman of the Board and
Chief Executive Officer
(principal executive officer)
May 30, 2002
/s/ Craig A. Rosen, Ph.D.
Craig A. Rosen, Ph.D.
Executive Vice President, Research
and Development and Director
May 30, 2002
/s/ Steven C. Mayer
Steven C. Mayer
Senior Vice President and
Chief Financial Officer
(principal financial and accounting officer)
May 30, 2002
/s/ Richard J. Danzig
Richard J. Danzig
Director
May 30, 2002
Jurgen Drews, M.D.
Director
May 30, 2002
Richard C. Holbrooke
Director
May 30, 2002
/s/ Robert Hormats
Robert Hormats
Director
May 30, 2002
/s/ Argeris (Jerry) N. Karabelas, Ph.D.
Argeris (Jerry) N. Karabelas, Ph.D.
Director
May 30, 2002
/s/ Max Link, Ph.D.
Max Link, Ph.D.
Director
May 30, 2002
/s/ Alan G. Spoon
Alan G. Spoon
Director
May 30, 2002
/s/ Laura D'Andrea Tyson, Ph.D.
Laura D'Andrea Tyson, Ph.D.
Director
May 30, 2002
/s/ James Barnes Wyngaarden, M.D.
James Barnes Wyngaarden, M.D.
Director
May 30, 2002
EXHIBIT INDEX
EXHIBIT
NUMBER
DESCRIPTION
4.1
Certificate of Incorporation of the Registrant (filed as Exhibit 3.1 of
the Registrant's Annual Report on Form 10-K for the year ended December
31, 1993, Exhibit 3.3 to the Registrant's Annual Report on Form 10-K for
the year ended December 31, 1997, as Exhibit 3.1 to the Registrant's
Current Report on Form 8-K filed on December 16, 1999, and Exhibit 3.1 to
the Registrant's Quarterly Report on Form 10-Q for the quarter ended June
30, 2001, and incorporated herein by reference)
4.2
By-Laws of the Registrant (filed as Exhibit 3.2 to the Registrant's
Quarterly Report on Form 10-Q for the quarter ended June 30, 2000, and
incorporated herein by reference)
4.3
Rights Agreement between the Registrant and American Stock Transfer &
Trust Company, as Rights Agent, dated as of May 20, 1998 (filed as Exhibit
4 of the Registrant's Current Report on Form 8-K filed on may 28, 1998,
and incorporated herein by reference).
4.4
Indenture dated as of June 25, 1999 between the Registrant and The Bank
of New York, as trustee, including the form of 5-1/2% Convertible
Subordinated Notes due 2006 (filed as Exhibit 4.1 to the Registrant's Form
8 -K filed June 28, 1999)
4.5
Indenture dated as of February 1, 2000 between the Registrant and The
Bank of New York, as trustee, including the form of 5% Convertible
Subordinated Notes due 2007 (filed as Exhibit 4.1 to the Registrant's Form
8-K filed February 2, 2000)
4.6
Indenture dated as of March 10, 2000 between the Registrant and The Bank
of New York, as trustee, including the form of 3-3/4% Convertible
Subordinated Notes due 2007 (filed as Exhibit 4.1 to the Registrant's Form
8-K filed March 13, 2000)
4.7
Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive
Plan (filed as Exhibit A of the Registrant's Definitive Proxy Statement on
Schedule 14A, filed April 18, 2001, and incorporated herein by reference).
5.1*
Opinion of Piper Rudnick LLP, counsel for the Registrant, regarding the
legal validity of the shares of Common Stock being registered under this
Registration Statement
23.1*
Consent of Piper Rudnick LLP, counsel for the Registrant (contained in Exhibit 5.1)
23.2*
Consent of Ernst & Young LLP, Independent Auditors
24.1*
Power of Attorney (included on Signature Page)
*
Filed herewith.