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<DIV align="right" style="font-size: 10pt; margin-top: 12pt"><B>As filed with the Securities and Exchange Commission on February 28, 2007<br>
Registration No.&nbsp;333-</B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</DIV>


<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>






<DIV align="center" style="font-size: 14pt; margin-top: 10pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B>
</DIV>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>

<DIV align="center" style="font-size: 12pt"><B><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></B>
</DIV>

<DIV align="center" style="font-size: 18pt; margin-top: 10pt"><B>FORM S-8</B>
</DIV>


<DIV align="center" style="font-size: 12pt; margin-top: 10pt"><B>REGISTRATION STATEMENT</B><BR>
<B><I>Under<BR>
The Securities Act of 1933</I></B>
</DIV>

<DIV align="center" style="font-size: 24pt; margin-top: 10pt"><B>CYTOKINETICS, INCORPORATED</B>
</DIV>

<DIV align="center" style="font-size: 10pt"><B>(Exact name of Registrant as specified in its charter)</B>
<DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>
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<TR valign="bottom">
    <TD align="center" valign="top"><B>Delaware</B><BR>
<div style="font-size: 8pt"><B>(State or other jurisdiction of <BR>incorporation or organization)</B></div>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>94-3291317<BR>
<div style="font-size: 8pt"> (I.R.S. Employer<BR>
Identification Number)</B></div></TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 10pt"><B>280 East Grand Avenue<BR>
South San Francisco, CA 94080<BR>
<div style="font-size: 8pt"> (Address of principal executive
offices)</B></div></DIV>





<DIV align="center" style="font-size: 10pt; margin-top: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>


<DIV align="center" style="font-size: 12pt; margin-top: 10pt"><B>2004 EQUITY INCENTIVE PLAN</B>
</DIV>

<DIV align="center" style="font-size: 8pt"><B>(Full title of the plan)</B></DIV>


<DIV align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Robert I. Blum<BR>
President and Chief Executive Officer<BR>
Cytokinetics, Incorporated<BR>
280 East Grand Avenue<BR>
South San Francisco, CA 94080<BR>
(650)&nbsp;624-3000<BR>
<div style="font-size: 8pt"> (Name, address, and telephone number,
including area code, of agent for service)</B></DIV></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><I>Copy to:</I><BR>
<B>Michael J. O&#146;Donnell, Esq.<BR>
Martin J. Waters, Esq.<BR>
Gavin McCraley, Esq.<BR>
Wilson Sonsini Goodrich &#038; Rosati<BR>
Professional Corporation<BR>
650 Page Mill Road<BR>
Palo Alto, CA 94304-1050<BR>
(650)&nbsp;493-9300</B></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt">CALCULATION OF REGISTRATION FEE</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="1%">&nbsp;</TD>
    <TD width="20%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD><!-- VRule -->
    <TD width="1%">&nbsp;</TD>
    <TD width="17%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD><!-- VRule -->
    <TD width="1%">&nbsp;</TD>
    <TD width="17%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD><!-- VRule -->
    <TD width="1%">&nbsp;</TD>
    <TD width="17%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD><!-- VRule -->
    <TD width="1%">&nbsp;</TD>
    <TD width="17%">&nbsp;</TD>

    <TD width="1%">&nbsp;</TD>
</TR><TR style="font-size: 1px" valign="bottom">
    <TD nowrap align="left" colspan="15" style="border-bottom: 3px double #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Proposed</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Proposed</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD nowrap align="center"><B>Title of</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Maximum</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Maximum</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Maximum</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD nowrap align="center"><B>Securities</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Amount</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Offering</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Aggregate</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Amount of</B></TD>
    <TD width="1%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">    <TD width="1%" >&nbsp;</TD>

    <TD nowrap align="center"><B>to be</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>to be</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Price Per</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Offering</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Registration</B></TD>
    <TD width="1%" >&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">    <TD width="1%">&nbsp;</TD>

    <TD nowrap align="center"><B>Registered</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Registered (1)</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Share (2)</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Price</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Fee</B></TD>
    <TD width="1%">&nbsp;</TD>
</TR>

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<TR valign="bottom">
    <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>

<TD align="left" valign="top" style="border-top: 1px solid #000000">2004
Equity Incentive Plan, Common Stock $0.001 par value </TD>
    <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="center" valign="bottom" style="border-top: 1px solid #000000">1,500,000 shares
</TD>
    <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="center" valign="bottom" style="border-top: 1px solid #000000">$8.365
</TD>
    <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="center" valign="bottom" style="border-top: 1px solid #000000">$12,547,500.00
</TD>
    <TD style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="center" valign="bottom" style="border-top: 1px solid #000000">$385.21</TD>
    <TD width="1%" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 1px" valign="bottom">
    <TD nowrap align="left" colspan="15" style="border-top: 3px double #000000">&nbsp;</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>

<DIV style="margin-top: 3pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Represents an additional 1,500,000 shares of Common Stock available for issuance under the Company&#146;s 2004 Equity
Incentive Plan, as a result of provisions in the Company&#146;s 2004 Equity Incentive Plan that allow automatic annual
increases of Common Stock available for issuance under such plan.</TD>
</TR>

<TR>
    <TD style="font-size: 3pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Estimated in accordance with Rule 457(h) solely for the purpose of calculating the total registration fee. No
options have been granted with respect to such shares. The computation is based upon the average of the high and low
prices of the Common Stock as reported on The NASDAQ Global Market on February&nbsp;26, 2007.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>





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<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Statement Under General Instruction E<BR>
Registration of Additional Securities</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Unless as noted herein, the contents of the Cytokinetics, Incorporated&#146;s (the &#147;Company&#148; or the
&#147;Registrant&#148;) Form S-8 Registration Statement (File No.&nbsp;333-115146) are incorporated by reference
into this Registration Statement.
</DIV>

<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>PART II<BR>
INFORMATION REQUIRED IN REGISTRATION STATEMENT</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;3. Incorporation of Documents by Reference.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;There are hereby incorporated by reference in this Registration Statement the following
documents and information heretofore filed by the Company with the Securities and Exchange
Commission:
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;The Company&#146;s Annual Report filed on Form 10-K for the fiscal year ended December&nbsp;31,
2005.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;The Company&#146;s Definitive Proxy Statement on Schedule&nbsp;14A, filed on April&nbsp;4, 2006.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;The Company&#146;s Quarterly Reports filed on Form 10-Q for the fiscal quarters ended March&nbsp;31,
2006, June&nbsp;30, 2006, and September&nbsp;30, 2006.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4)&nbsp;The Company&#146;s Current Reports on Form 8-K dated January&nbsp;18, 2006, January&nbsp;20, 2006,
January&nbsp;31, 2006, February&nbsp;10, 2006, March&nbsp;7, 2006, March&nbsp;22, 2006, March&nbsp;30, 2006, April&nbsp;27, 2006,
June&nbsp;7, 2006, June&nbsp;19, 2006, June&nbsp;29, 2006, July&nbsp;27, 2006, August&nbsp;23, 2006, September&nbsp;13, 2006,
October&nbsp;2, 2006, October&nbsp;26, 2006, November&nbsp;13, 2006, November&nbsp;15, 2006, November&nbsp;27, 2006,
December&nbsp;1, 2006, December&nbsp;7, 2006, December&nbsp;12, 2006, December&nbsp;20, 2006, January&nbsp;3, 2007, January
22, 2007 and January&nbsp;31, 2007.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(5)&nbsp;The description of the Company&#146;s Common Stock contained in the Company&#146;s Registration
Statement on Form 8-A filed pursuant to the Exchange Act, as amended, and as declared effective on
April&nbsp;29, 2004.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the
Securities Exchange Act of 1934 on or after the date of this Registration Statement and prior to
the filing of a post-effective amendment which indicates that all securities offered have been sold
or which deregisters all securities then remaining unsold shall be deemed to be incorporated by
reference in this Registration Statement and to be part hereof from the date of filing of such
documents.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Certain members of Wilson Sonsini Goodrich &#038; Rosati, Professional Corporation, and investment
partnerships of which such persons are partners, beneficially own 431 shares of the Company&#146;s
Common Stock.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;8. Exhibits.</B>
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="70%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Number</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Description</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-center:0px; text-indent:-0px">4.1 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Common Stock Certificate.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-center:0px; text-indent:-0px">4.2 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Fourth Amended and Restated Investors Rights Agreement, dated March&nbsp;21, 2003, by and
among the Registrant and certain stockholders of the Registrant.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.3 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Loan and Security Agreement, dated September&nbsp;25, 1998, by and between the Registrant
and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.4 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amendment No.&nbsp;One to Loan and Security Agreement, dated February&nbsp;1, 1999.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.5 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;A preferred stock, dated September&nbsp;25,
1998, issued by the Registrant to Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.6 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Loan and Security Agreement, dated December&nbsp;16, 1999, by and between the Registrant and
Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.7 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amendment No.&nbsp;1 to Loan and Security Agreement, dated June&nbsp;29, 2000, by and between the
Registrant and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.8 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;B preferred stock, dated December&nbsp;16,
1999, issued by the Registrant to Comdisco.</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="70%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Number</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Description</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.9 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Master Security Agreement, dated February&nbsp;2, 2001, by and between the Registrant and
General Electric Capital Corporation.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.10 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Cross-Collateral and Cross-Default Agreement by and between the Registrant and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.11 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999, issued by the
Registrant to Bristow Investments, L.P.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.12 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999, issued by the
Registrant to the Laurence and Magdalena Shushan Family Trust.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.13 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999, issued by the
Registrant to Slough Estates USA Inc.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.14 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;B preferred stock, dated August&nbsp;30, 1999,
issued by the Registrant to The Magnum Trust.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.15 <SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated October&nbsp;28, 2005, issued by
the Registrant to Kingsbridge Capital Limited.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.16 <SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Registration Rights Agreement, dated October&nbsp;28, 2005, by and between the Registrant
and Kingsbridge Capital Limited.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.17 <SUP style="font-size: 85%; vertical-align: text-top">(3)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Registration Rights Agreement, dated as of December&nbsp;29, 2006, by and between the
Registrant and Amgen Inc.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:15px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Wilson Sonsini Goodrich &#038; Rosati, Professional Corporation.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">10.3 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">2004 Equity Incentive Plan.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Wilson Sonsini Goodrich &#038; Rosati, Professional Corporation (see Exhibit&nbsp;5.1).</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (see signature page).</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">(1)</TD>
    <TD>&nbsp;</TD>
    <TD>Incorporated by reference from the Registrant&#146;s registration statement on Form S-1,
registration number 333-112261, declared effective by the Securities and Exchange Commission
on April&nbsp;29, 2004.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(2)</TD>
    <TD>&nbsp;</TD>
    <TD>Incorporated by reference from the Registrant&#146;s Current Report on Form 8-K, filed with the
Securities and Exchange Commission on January&nbsp;20, 2006.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(3)</TD>
    <TD>&nbsp;</TD>
    <TD>Incorporated by reference from the Registrant&#146;s Current Report on Form 8-K, filed with the
Securities and Exchange Commission on January&nbsp;3, 2007.</TD>
</TR>

</TABLE>



<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;9. Undertakings.</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>A.&nbsp;&nbsp; The undersigned Registrant hereby undertakes:</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="5%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement:</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="9%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(i)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>To include any prospectus required by Section&nbsp;10(a)(3) of the
Securities Act;</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="9%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(ii)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>To reflect in the prospectus any facts or events arising after the
effective date of the Registration Statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the Registration Statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of the securities offered would not exceed that
which was registered) and any deviation from the low or high end of the estimated
maximum offering range may be reflected in the form of a prospectus filed with the
Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and
price represent no more than a 20% change in the maximum aggregate offering price
set forth in the &#147;Calculation of Registration Fee&#148; table in the effective
Registration Statement;</TD>
</TR>

</TABLE>
</DIV>
<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">



</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="9%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(iii)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>To include any material information with respect to the plan of
distribution not previously disclosed in the Registration Statement or any
material change to such information in the Registration Statement;</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <I>Provided, however</I>, that paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the
information required to be included in a post-effective amendment by those paragraphs
is contained in periodic reports filed with or furnished to the Commission by the
Registrant pursuant to Section&nbsp;13 or Section 15(d) of the Exchange Act that are
incorporated by reference in the Registration Statement.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>That, for the purpose of determining any liability under the Securities Act, each
such post-effective amendment shall be deemed to be a new Registration Statement relating
to the securities offered therein, and the offering of such securities at that time shall
be deemed to be the initial bona fide offering thereof.</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">(3)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>To remove from registration by means of a post-effective amendment any of the
securities being registered which remain unsold at the termination of the offering.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">B.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The undersigned Registrant hereby undertakes, that, for purposes of determining any liability
under the Securities Act, each filing of the Registrant&#146;s annual report pursuant to Section
13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee
benefit plan&#146;s annual report pursuant to Section 15(d) of the Exchange Act) that is
incorporated by reference in the Registration Statement shall be deemed to be a new
Registration Statement relating to the securities offered therein, and the offering of such
securities at the time shall be deemed to be the initial bona fide offering thereof.</TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">C.</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Insofar as indemnification for liabilities arising under the Securities Act may be permitted
to directors, officers and controlling persons of the Registrant pursuant to the foregoing
provisions, or otherwise, the Registrant has been advised that in the opinion of the
Commission, such indemnification as against public policy as expressed in the Securities Act
and is, therefore, unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Registrant of expenses incurred or paid by a
director, officer or controlling person of the Registrant in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or controlling person in
connection with securities being registered, the Registrant will, unless in the opinion of its
counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as
expressed in the Securities Act and will be governed by the final adjudication of such issue.</TD>
</TR>

</TABLE>
</DIV>

</div>
<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant, Cytokinetics,
Incorporated, a corporation organized and existing under the laws of the State of Delaware,
certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of South San Francisco, State of
California, on this 28&nbsp;day of February, 2007.
</DIV>

<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">CYTOKINETICS, INCORPORATED<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Robert I. Blum
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">Robert I. Blum&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">President and Chief Executive Officer<br>
(Principal Executive Officer)&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>POWER OF ATTORNEY</B>
</DIV>



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
and appoints Robert I. Blum and Sharon Surrey-Barbari, jointly and severally, as his
attorneys-in-fact, with full power of substitution in each, for him in any and all capacities to
sign any amendments to this Registration Statement on Form S-8, and to file the same, with all
exhibits thereto and other documents in connection therewith, with the Securities and Exchange
Commission, hereby ratifying and confirming all that each of said attorneys-in-fact, or his
substitutes, may do or cause to be done by virtue hereof.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed below by the following persons in the capacities and on the dates indicated.
</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="31%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="31%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="31%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/ Robert I. Blum<BR>
<DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
(Robert I. Blum)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">President, Chief Executive Officer and Director<BR>
(Principal Executive Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February&nbsp;28, 2007</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/ Sharon Surrey-Barbari<BR>
<DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
(Sharon Surrey-Barbari)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Chief Financial Officer (Principal Financial and
Accounting Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February&nbsp;28, 2007</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/ James Sabry.<BR>
<DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
(James Sabry, M.D., Ph.D.)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Executive Chairman and Director&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February&nbsp;28, 2007</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/ Stephen Dow<BR>
<DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
(Stephen Dow)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Director&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February&nbsp;28, 2007</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 28, 2007</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/ A. Grant Heidrich, III<BR><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
(A. Grant Heidrich, III)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/ Charles Homcy, M.D.<BR>
<DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
(Charles Homcy, M.D.)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Director&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February&nbsp;28, 2007</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 28, 2007</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/ Mark McDade<BR><DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
(Mark McDade)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/ Michael Schmertzler<BR>
<DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
(Michael Schmertzler)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Director&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February&nbsp;28, 2007</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">/s/ James Spudich, Ph.D.<BR>
<DIV style="font-size: 1pt; border-top: 1px solid #000000">&nbsp;</DIV>
(James Spudich, Ph.D.)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Director&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February&nbsp;28, 2007</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>INDEX TO EXHIBITS</B>
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="70%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Number</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Description</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.1 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Common Stock Certificate.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.2 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Fourth Amended and Restated Investors Rights Agreement, dated March&nbsp;21, 2003, by and
among the Registrant and certain stockholders of the Registrant.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.3 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Loan and Security Agreement, dated September&nbsp;25, 1998, by and between the Registrant
and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.4 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amendment No.&nbsp;One to Loan and Security Agreement, dated February&nbsp;1, 1999.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.5 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;A preferred stock, dated September&nbsp;25,
1998, issued by the Registrant to Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.6 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Loan and Security Agreement, dated December&nbsp;16, 1999, by and between the Registrant and
Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.7 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amendment No.&nbsp;1 to Loan and Security Agreement, dated June&nbsp;29, 2000, by and between the
Registrant and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.8 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;B preferred stock, dated December&nbsp;16,
1999, issued by the Registrant to Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.9 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Master Security Agreement, dated February&nbsp;2, 2001, by and between the Registrant and
General Electric Capital Corporation.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.10 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Cross-Collateral and Cross-Default Agreement by and between the Registrant and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.11 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999, issued by the
Registrant to Bristow Investments, L.P.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.12 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999, issued by the
Registrant to the Laurence and Magdalena Shushan Family Trust.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.13 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999, issued by the
Registrant to Slough Estates USA Inc.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.14 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;B preferred stock, dated August&nbsp;30, 1999,
issued by the Registrant to The Magnum Trust.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.15 <SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated October&nbsp;28, 2005, issued by
the Registrant to Kingsbridge Capital Limited.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.16 <SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Registration Rights Agreement, dated October&nbsp;28, 2005, by and between the Registrant
and Kingsbridge Capital Limited.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">4.17 <SUP style="font-size: 85%; vertical-align: text-top">(3)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Registration Rights Agreement, dated as of December&nbsp;29, 2006, by and between the
Registrant and Amgen Inc.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Wilson Sonsini Goodrich &#038; Rosati, Professional Corporation.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">10.3 <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">2004 Equity Incentive Plan.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Wilson Sonsini Goodrich &#038; Rosati, Professional Corporation (see Exhibit&nbsp;5.1).</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><DIV style="margin-left:10px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (see page signature page).</TD>
</TR>
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<TR valign="top">
    <TD nowrap align="left">(1)</TD>
    <TD>&nbsp;</TD>
    <TD>Incorporated by reference from the Registrant&#146;s registration statement on Form S-1,
registration number 333-112261, declared effective by the Securities and Exchange Commission
on April&nbsp;29, 2004.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

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    <TD nowrap align="left">(2)</TD>
    <TD>&nbsp;</TD>
    <TD>Incorporated by reference from the Registrant&#146;s Current Report on Form 8-K, filed with the
Securities and Exchange Commission on January&nbsp;20, 2006.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

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    <TD nowrap align="left">(3)</TD>
    <TD>&nbsp;</TD>
    <TD>Incorporated by reference from the Registrant&#146;s Current Report on Form 8-K, filed with the
Securities and Exchange Commission on January&nbsp;3, 2007.</TD>
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[{"type": "S-8", "sequence": "1", "filename": "f27774sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 53795}]
{"company-data": {"conformed-name": "CYTOKINETICS INC", "cik": "0001061983", "assigned-sic": "2834", "irs-number": "943291317"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-140963", "film-number": "07658852"}, "business-address": {"street1": "280 EAST GRAND AVENUE", "street2": ".", "city": "SOUTH SAN FRANCISCO", "state": "CA", "zip": "94080", "phone": "(650) 624-3000"}, "mail-address": {"street1": "280 EAST GRAND AVENUE", "city": "SOUTH SAN FRANCISCO", "state": "CA", "zip": "94080"}}
sv8
As filed with the Securities and Exchange Commission on February 28, 2007
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
CYTOKINETICS, INCORPORATED
(Exact name of Registrant as specified in its charter)
Delaware
(State or other jurisdiction of
incorporation or organization)
94-3291317
(I.R.S. Employer
Identification Number)
280 East Grand Avenue
South San Francisco, CA 94080
(Address of principal executive
offices)
2004 EQUITY INCENTIVE PLAN
(Full title of the plan)
Robert I. Blum
President and Chief Executive Officer
Cytokinetics, Incorporated
280 East Grand Avenue
South San Francisco, CA 94080
(650) 624-3000
(Name, address, and telephone number,
including area code, of agent for service)
Copy to:
Michael J. O'Donnell, Esq.
Martin J. Waters, Esq.
Gavin McCraley, Esq.
Wilson Sonsini Goodrich & Rosati
Professional Corporation
650 Page Mill Road
Palo Alto, CA 94304-1050
(650) 493-9300
CALCULATION OF REGISTRATION FEE
Proposed
Proposed
Title of
Maximum
Maximum
Maximum
Securities
Amount
Offering
Aggregate
Amount of
to be
to be
Price Per
Offering
Registration
Registered
Registered (1)
Share (2)
Price
Fee
2004
Equity Incentive Plan, Common Stock $0.001 par value
1,500,000 shares
$8.365
$12,547,500.00
$385.21
(1)
Represents an additional 1,500,000 shares of Common Stock available for issuance under the Company's 2004 Equity
Incentive Plan, as a result of provisions in the Company's 2004 Equity Incentive Plan that allow automatic annual
increases of Common Stock available for issuance under such plan.
(2)
Estimated in accordance with Rule 457(h) solely for the purpose of calculating the total registration fee. No
options have been granted with respect to such shares. The computation is based upon the average of the high and low
prices of the Common Stock as reported on The NASDAQ Global Market on February 26, 2007.
Statement Under General Instruction E
Registration of Additional Securities
Unless as noted herein, the contents of the Cytokinetics, Incorporated's (the "Company" or the
"Registrant") Form S-8 Registration Statement (File No. 333-115146) are incorporated by reference
into this Registration Statement.
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
There are hereby incorporated by reference in this Registration Statement the following
documents and information heretofore filed by the Company with the Securities and Exchange
Commission:
(1) The Company's Annual Report filed on Form 10-K for the fiscal year ended December 31,
2005.
(2) The Company's Definitive Proxy Statement on Schedule 14A, filed on April 4, 2006.
(3) The Company's Quarterly Reports filed on Form 10-Q for the fiscal quarters ended March 31,
2006, June 30, 2006, and September 30, 2006.
(4) The Company's Current Reports on Form 8-K dated January 18, 2006, January 20, 2006,
January 31, 2006, February 10, 2006, March 7, 2006, March 22, 2006, March 30, 2006, April 27, 2006,
June 7, 2006, June 19, 2006, June 29, 2006, July 27, 2006, August 23, 2006, September 13, 2006,
October 2, 2006, October 26, 2006, November 13, 2006, November 15, 2006, November 27, 2006,
December 1, 2006, December 7, 2006, December 12, 2006, December 20, 2006, January 3, 2007, January
22, 2007 and January 31, 2007.
(5) The description of the Company's Common Stock contained in the Company's Registration
Statement on Form 8-A filed pursuant to the Exchange Act, as amended, and as declared effective on
April 29, 2004.
All documents filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the
Securities Exchange Act of 1934 on or after the date of this Registration Statement and prior to
the filing of a post-effective amendment which indicates that all securities offered have been sold
or which deregisters all securities then remaining unsold shall be deemed to be incorporated by
reference in this Registration Statement and to be part hereof from the date of filing of such
documents.
Item 5. Interests of Named Experts and Counsel.
Certain members of Wilson Sonsini Goodrich & Rosati, Professional Corporation, and investment
partnerships of which such persons are partners, beneficially own 431 shares of the Company's
Common Stock.
Item 8. Exhibits.
Exhibit
Number
Description
4.1
(1)
Specimen Common Stock Certificate.
4.2
(1)
Fourth Amended and Restated Investors Rights Agreement, dated March 21, 2003, by and
among the Registrant and certain stockholders of the Registrant.
4.3
(1)
Loan and Security Agreement, dated September 25, 1998, by and between the Registrant
and Comdisco.
4.4
(1)
Amendment No. One to Loan and Security Agreement, dated February 1, 1999.
4.5
(1)
Warrant for the purchase of shares of Series A preferred stock, dated September 25,
1998, issued by the Registrant to Comdisco.
4.6
(1)
Loan and Security Agreement, dated December 16, 1999, by and between the Registrant and
Comdisco.
4.7
(1)
Amendment No. 1 to Loan and Security Agreement, dated June 29, 2000, by and between the
Registrant and Comdisco.
4.8
(1)
Warrant for the purchase of shares of Series B preferred stock, dated December 16,
1999, issued by the Registrant to Comdisco.
Exhibit
Number
Description
4.9
(1)
Master Security Agreement, dated February 2, 2001, by and between the Registrant and
General Electric Capital Corporation.
4.10
(1)
Cross-Collateral and Cross-Default Agreement by and between the Registrant and Comdisco.
4.11
(1)
Warrant for the purchase of shares of common stock, dated July 20, 1999, issued by the
Registrant to Bristow Investments, L.P.
4.12
(1)
Warrant for the purchase of shares of common stock, dated July 20, 1999, issued by the
Registrant to the Laurence and Magdalena Shushan Family Trust.
4.13
(1)
Warrant for the purchase of shares of common stock, dated July 20, 1999, issued by the
Registrant to Slough Estates USA Inc.
4.14
(1)
Warrant for the purchase of shares of Series B preferred stock, dated August 30, 1999,
issued by the Registrant to The Magnum Trust.
4.15
(2)
Warrant for the purchase of shares of common stock, dated October 28, 2005, issued by
the Registrant to Kingsbridge Capital Limited.
4.16
(2)
Registration Rights Agreement, dated October 28, 2005, by and between the Registrant
and Kingsbridge Capital Limited.
4.17
(3)
Registration Rights Agreement, dated as of December 29, 2006, by and between the
Registrant and Amgen Inc.
5.1
Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation.
10.3
(1)
2004 Equity Incentive Plan.
23.1
Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (see Exhibit 5.1).
24.1
Power of Attorney (see signature page).
(1)
Incorporated by reference from the Registrant's registration statement on Form S-1,
registration number 333-112261, declared effective by the Securities and Exchange Commission
on April 29, 2004.
(2)
Incorporated by reference from the Registrant's Current Report on Form 8-K, filed with the
Securities and Exchange Commission on January 20, 2006.
(3)
Incorporated by reference from the Registrant's Current Report on Form 8-K, filed with the
Securities and Exchange Commission on January 3, 2007.
Item 9. Undertakings.
A.   The undersigned Registrant hereby undertakes:
(1)
To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement:
(i)
To include any prospectus required by Section 10(a)(3) of the
Securities Act;
(ii)
To reflect in the prospectus any facts or events arising after the
effective date of the Registration Statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the Registration Statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of the securities offered would not exceed that
which was registered) and any deviation from the low or high end of the estimated
maximum offering range may be reflected in the form of a prospectus filed with the
Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and
price represent no more than a 20% change in the maximum aggregate offering price
set forth in the "Calculation of Registration Fee" table in the effective
Registration Statement;
(iii)
To include any material information with respect to the plan of
distribution not previously disclosed in the Registration Statement or any
material change to such information in the Registration Statement;
Provided, however
, that paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the
information required to be included in a post-effective amendment by those paragraphs
is contained in periodic reports filed with or furnished to the Commission by the
Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are
incorporated by reference in the Registration Statement.
(2)
That, for the purpose of determining any liability under the Securities Act, each
such post-effective amendment shall be deemed to be a new Registration Statement relating
to the securities offered therein, and the offering of such securities at that time shall
be deemed to be the initial bona fide offering thereof.
(3)
To remove from registration by means of a post-effective amendment any of the
securities being registered which remain unsold at the termination of the offering.
B.
The undersigned Registrant hereby undertakes, that, for purposes of determining any liability
under the Securities Act, each filing of the Registrant's annual report pursuant to Section
13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee
benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is
incorporated by reference in the Registration Statement shall be deemed to be a new
Registration Statement relating to the securities offered therein, and the offering of such
securities at the time shall be deemed to be the initial bona fide offering thereof.
C.
Insofar as indemnification for liabilities arising under the Securities Act may be permitted
to directors, officers and controlling persons of the Registrant pursuant to the foregoing
provisions, or otherwise, the Registrant has been advised that in the opinion of the
Commission, such indemnification as against public policy as expressed in the Securities Act
and is, therefore, unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Registrant of expenses incurred or paid by a
director, officer or controlling person of the Registrant in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or controlling person in
connection with securities being registered, the Registrant will, unless in the opinion of its
counsel the matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as
expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant, Cytokinetics,
Incorporated, a corporation organized and existing under the laws of the State of Delaware,
certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of South San Francisco, State of
California, on this 28 day of February, 2007.
CYTOKINETICS, INCORPORATED
By:
/s/ Robert I. Blum
Robert I. Blum
President and Chief Executive Officer
(Principal Executive Officer)
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
and appoints Robert I. Blum and Sharon Surrey-Barbari, jointly and severally, as his
attorneys-in-fact, with full power of substitution in each, for him in any and all capacities to
sign any amendments to this Registration Statement on Form S-8, and to file the same, with all
exhibits thereto and other documents in connection therewith, with the Securities and Exchange
Commission, hereby ratifying and confirming all that each of said attorneys-in-fact, or his
substitutes, may do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed below by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Robert I. Blum
(Robert I. Blum)
President, Chief Executive Officer and Director
(Principal Executive Officer)
February 28, 2007
/s/ Sharon Surrey-Barbari
(Sharon Surrey-Barbari)
Chief Financial Officer (Principal Financial and
Accounting Officer)
February 28, 2007
/s/ James Sabry.
(James Sabry, M.D., Ph.D.)
Executive Chairman and Director
February 28, 2007
/s/ Stephen Dow
(Stephen Dow)
Director
February 28, 2007
Director
February 28, 2007
/s/ A. Grant Heidrich, III
(A. Grant Heidrich, III)
/s/ Charles Homcy, M.D.
(Charles Homcy, M.D.)
Director
February 28, 2007
Director
February 28, 2007
/s/ Mark McDade
(Mark McDade)
/s/ Michael Schmertzler
(Michael Schmertzler)
Director
February 28, 2007
/s/ James Spudich, Ph.D.
(James Spudich, Ph.D.)
Director
February 28, 2007
INDEX TO EXHIBITS
Exhibit
Number
Description
4.1
(1)
Specimen Common Stock Certificate.
4.2
(1)
Fourth Amended and Restated Investors Rights Agreement, dated March 21, 2003, by and
among the Registrant and certain stockholders of the Registrant.
4.3
(1)
Loan and Security Agreement, dated September 25, 1998, by and between the Registrant
and Comdisco.
4.4
(1)
Amendment No. One to Loan and Security Agreement, dated February 1, 1999.
4.5
(1)
Warrant for the purchase of shares of Series A preferred stock, dated September 25,
1998, issued by the Registrant to Comdisco.
4.6
(1)
Loan and Security Agreement, dated December 16, 1999, by and between the Registrant and
Comdisco.
4.7
(1)
Amendment No. 1 to Loan and Security Agreement, dated June 29, 2000, by and between the
Registrant and Comdisco.
4.8
(1)
Warrant for the purchase of shares of Series B preferred stock, dated December 16,
1999, issued by the Registrant to Comdisco.
4.9
(1)
Master Security Agreement, dated February 2, 2001, by and between the Registrant and
General Electric Capital Corporation.
4.10
(1)
Cross-Collateral and Cross-Default Agreement by and between the Registrant and Comdisco.
4.11
(1)
Warrant for the purchase of shares of common stock, dated July 20, 1999, issued by the
Registrant to Bristow Investments, L.P.
4.12
(1)
Warrant for the purchase of shares of common stock, dated July 20, 1999, issued by the
Registrant to the Laurence and Magdalena Shushan Family Trust.
4.13
(1)
Warrant for the purchase of shares of common stock, dated July 20, 1999, issued by the
Registrant to Slough Estates USA Inc.
4.14
(1)
Warrant for the purchase of shares of Series B preferred stock, dated August 30, 1999,
issued by the Registrant to The Magnum Trust.
4.15
(2)
Warrant for the purchase of shares of common stock, dated October 28, 2005, issued by
the Registrant to Kingsbridge Capital Limited.
4.16
(2)
Registration Rights Agreement, dated October 28, 2005, by and between the Registrant
and Kingsbridge Capital Limited.
4.17
(3)
Registration Rights Agreement, dated as of December 29, 2006, by and between the
Registrant and Amgen Inc.
5.1
Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation.
10.3
(1)
2004 Equity Incentive Plan.
23.1
Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (see Exhibit 5.1).
24.1
Power of Attorney (see page signature page).
(1)
Incorporated by reference from the Registrant's registration statement on Form S-1,
registration number 333-112261, declared effective by the Securities and Exchange Commission
on April 29, 2004.
(2)
Incorporated by reference from the Registrant's Current Report on Form 8-K, filed with the
Securities and Exchange Commission on January 20, 2006.
(3)
Incorporated by reference from the Registrant's Current Report on Form 8-K, filed with the
Securities and Exchange Commission on January 3, 2007.