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<P align="center"><FONT size="2">SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549<BR>
&#95;&#95;&#95;&#95;&#95;&#95;
</FONT>
<P align="center"><FONT size="2">FORM S-8
</FONT>
<P align="center"><FONT size="2">REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
</FONT>
<P align="center"><FONT size="2">ENTREMED, INC.<BR>
(Exact Name of registrant as specified in its charter)
</FONT>
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    <TD width="50%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="45%">&nbsp;</TD>
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    <TD align="center" valign="top"><FONT size="2">Delaware</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
58-1959440</FONT></TD>
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    <TD align="center" valign="top"><HR size="1" noshade></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
<HR size="1" noshade></FONT></TD>
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    <TD align="center" valign="top"><FONT size="2">(State or other jurisdiction of</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
(I.R.S. Employer</FONT></TD>
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<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2">incorporation or organization)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Identification No.)</FONT></TD>
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<P align="center"><FONT size="2">9640 Medical Center Drive<BR>
<U>&nbsp;&nbsp;&nbsp;&nbsp;Rockville, Maryland&nbsp;&nbsp;20850&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
(Address, including zip code, of principal executive offices)
</FONT>
<P align="center"><FONT size="2"><U>EntreMed, Inc. 2001 Long-Term Incentive Plan</U><BR>
(Full title of the plan)
</FONT>
<P align="center"><FONT size="2">John W. Holaday, Ph.D.<BR>
EntreMed, Inc.<BR>
9640 Medical Center Drive<BR>
Rockville, Maryland 20850<BR>
(240)&nbsp;864-2600<BR>
(Name, address, including zip code, and telephone number including area code, of agent for service)
</FONT>
<P align="center"><FONT size="2">Copy to:<BR>
Richard E. Baltz, Esq.<BR>
Arnold &#038; Porter<BR>
555 12th Street, N.W.
Washington, D.C. 20004<BR>
(202)&nbsp;942-5124<BR>
&#95;&#95;&#95;&#95;&#95;&#95;</FONT>
<P align="center"><FONT size="2">Calculation of Registration Fee
</FONT>
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    <TD width="27%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="4%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="4%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="8%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="9%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="2">Proposed maximum</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="2">Proposed maximum</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="2">Title of securities</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="2">Amount to be</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="2">offering price per</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="2">aggregate offering</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="2">Amount of</FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="2">to be registered</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="2">registered (1)</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="2">unit (2)(3)</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="2">price (3)</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="2">registration fee</FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
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<TR valign="bottom" bgcolor="#eeeeee">
    <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock,
$.01 par value</FONT></DIV></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">1,000,000</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">1.455</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">1,455,000</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">133.86</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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<P>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
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      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Pursuant to Rule&nbsp;416, promulgated under the Securities Act of 1933, as
amended, an additional undeterminable number of shares of Common Stock is
being registered to cover any adjustment in the number of shares of Common
Stock issuable pursuant to the anti-dilution provisions of the 2001
Long-Term Incentive Plan.</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
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<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Calculated on the basis of the average of the high and low sale prices of
the Registrant&#146;s Common Stock as reported on November&nbsp;22, 2002 on the
Nasdaq National Market which date is within 5 business days prior to the
date of the filing of this Registration Statement.</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Estimated solely for the purpose of determining the registration fee in
accordance with Rule&nbsp;457(h).</FONT></TD>
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<P align="center"><FONT size="2">EXPLANATORY NOTE AND INCORPORATION BY REFERENCE
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement registers additional shares of EntreMed,
Inc.&#146;s (the &#147;Company&#148;) common stock, $.01 par value per share (the &#147;Common
Stock&#148;), issuable under the Company&#146;s 2001 Long-Term Incentive Plan (the
&#147;Plan&#148;). The Company previously filed a Registration Statement on Form&nbsp;S-8
with the Securities and Exchange Commission (File No.&nbsp;333-68048) registering
2,250,000 shares of its Common Stock issuable under the Plan (the &#147;Original
Registration Statement&#148;). On June&nbsp;24, 2002, the stockholders of the Company
approved an amendment to the Plan that increases by 1,000,000 shares the total
number of shares of Common Stock available for grant or award thereunder.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with General Instruction E to Form&nbsp;S-8, except as set forth
below, the contents of the Original Registration Statement are incorporated by
reference herein.
</FONT>
<P align="center"><FONT size="2">&nbsp;</FONT>
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<P align="center"><FONT size="2"><B>PART II<BR>
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
</FONT>

<P><FONT size="2"><B>Item&nbsp;3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Incorporation of Documents by Reference</U>.</B>
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by EntreMed, Inc. (&#147;Registrant&#148; or
&#147;Company&#148;) (File No.&nbsp;000-20713) with the Securities and Exchange Commission
(&#147;SEC&#148;) under the Securities Exchange Act of 1934, as amended (&#147;Exchange Act&#148;),
are incorporated herein by reference:
</FONT>
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        <TD width="1%" align="left" nowrap><FONT size="2">(a)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">The Company&#146;s Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31,
2001, filed with the Commission on March&nbsp;12, 2002; and on Form&nbsp;10-K/A for the
year ended December&nbsp;31, 2001, filed with the Commission on March&nbsp;18, 2002.</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
        <TD width="1%" align="left" nowrap><FONT size="2">(b)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">The Company&#146;s Quarterly Reports on Form&nbsp;10-Q for the quarter ended
September&nbsp;30, 2002, filed with the Commission on November&nbsp;14, 2002; on
Form&nbsp;10-Q for the quarter ended June&nbsp;30, 2002, filed with the Commission
on August&nbsp;14, 2002 and on Form&nbsp;10-Q/A for the Quarter ended June&nbsp;30, 2001,
filed with the Commission on March&nbsp;15, 2002; on Form&nbsp;10-Q for the quarter
ended March&nbsp;31, 2002, filed with the Commission on May&nbsp;15, 2002; and on Form
10-Q/A for the Quarter ended June&nbsp;30, 2001, filed with the Commission on
March&nbsp;15, 2002.</FONT></TD>
</TR>
<TR>
        <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
        <TD width="1%" align="left" nowrap><FONT size="2">(c)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">The description of the common stock of the Company, par value $0.01 per
share (&#147;Common Stock&#148;), contained in a registration statement Form&nbsp;8-A
filed with the Commission on May&nbsp;14, 1996, and any amendments or reports
filed for the purpose of updating such description.</FONT></TD>
</TR>
</TABLE>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Registrant after the date of this Registration
Statement pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act,
prior to the filing of a post-effective amendment which indicates that all
Common Stock offered hereby has been sold or which deregisters such Common
Stock then remaining unsold, shall be deemed to be incorporated in this
Registration Statement by reference and shall be a part hereof from the date of
filing of such documents. Any statement contained in a document incorporated
or deemed to be incorporated by reference in this Registration Statement shall
be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein or in any other
subsequently filed document which also is or is deemed to be incorporated by
reference in this Registration Statement modifies or supersedes such statement.
Any such statement so modified or superseded shall not be deemed, except as so
modified or so superseded, to constitute a part of this Registration Statement.
</FONT>
<P><FONT size="2"><B>Item&nbsp;8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Exhibits</U></B>
</FONT>
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    <TD width="5%">&nbsp;</TD>
    <TD width="81%">&nbsp;</TD>
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<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;4</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
EntreMed, Inc. 2001 Long-Term Incentive Plan, as amended.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;5</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion of Arnold &#038; Porter, filed herewith.</FONT></TD>
</TR>
</TABLE>
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<P align="center"><FONT size="2">&nbsp;</FONT>
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<TR valign="bottom">
    <TD width="14%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="81%">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;23.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Arnold &#038; Porter, included in the opinion filed as Exhibit&nbsp;5 hereto.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;23.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, filed herewith.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;24</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Powers of Attorney of certain officers and directors of EntreMed, Inc.</FONT></TD>
</TR>
</TABLE>
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<P align="center"><FONT size="2">&nbsp;</FONT>
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<P><FONT size="2"><U><B>SIGNATURES</B></U></FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the Company certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form&nbsp;S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned thereunto
duly authorized in the City of Rockville, State of Maryland, on November&nbsp;27,
2002.
</FONT>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
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        <TD width="50%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="50%"><FONT size="2">ENTREMED, INC.<BR>
By:<B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B><U>/s/ Neil J. Campbell<B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></U></FONT></TD>
</TR>
</TABLE>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
this registration statement has been signed by the following persons in the
capacities and on the dates indicated:
</FONT>
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<TR valign="bottom">
    <TD width="36%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="33%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="21%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2"><u>Signature</u></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
<u>Title</u>
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2"><u>Date</u></FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Neil J. Campbell<BR>
</FONT><HR size="1" noshade><FONT size="2">
Neil J. Campbell</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
President and Chief<BR>
Operating Officer<BR>
(principal executive<BR>
officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">November 27, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2"><center>*</center><BR>
</FONT><HR size="1" noshade><FONT size="2">
Dane Saglio</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Principal Accounting and<BR>
Financial Officer
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">November 27, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ John H. Holaday<BR>
</FONT><HR size="1" noshade><FONT size="2">
John H. Holaday</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Chairman of the Board and<BR>
Chief Science Officer
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">November 27, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2"><center>*</center><BR>
</FONT><HR size="1" noshade><FONT size="2">
Wendell M. Starke</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Vice Chairman of the Board<BR>
and Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">November 27, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2"><center>*</center><BR>
</FONT><HR size="1" noshade><FONT size="2">
Donald S. Brooks</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">November 27, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2"><center>*</center><BR>
</FONT><HR size="1" noshade><FONT size="2">
Jerry Finkelstein</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">November 27, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;<BR>
</FONT><HR size="1" noshade><FONT size="2">
Jennie C. Hunter-Cevera</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">November 27, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2"><center>*</center><BR>
</FONT><HR size="1" noshade><FONT size="2">
Peter S. Knight</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">November 27, 2002</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2"><center>*</center><BR>
</FONT><HR size="1" noshade><FONT size="2">
Mark C.M. Randall</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">November 27, 2002</FONT></TD>
</TR>
</TABLE>
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<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
        <TD width="1%" align="left" nowrap><FONT size="2">*</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">By: <U>/s/ John W. Holaday, Ph.D.</U><br><B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B>John
W. Holaday, Ph.D.<br>
<B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B>Attorney-in-Fact</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">&nbsp;</FONT>
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<P><FONT size="2"><B><U>INDEX TO EXHIBITS</U></B>
</FONT>
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<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;4</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
EntreMed, Inc. 2001 Long-Term Incentive Plan, as amended, filed herewith.</FONT></TD>
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    <TD valign="top"><FONT size="2">Exhibit&nbsp;5</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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Opinion of Arnold &#038; Porter, filed herewith.</FONT></TD>
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    <TD valign="top"><FONT size="2">Exhibit&nbsp;23.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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Consent of Arnold &#038; Porter, included in the opinion filed as Exhibit&nbsp;5 hereto.</FONT></TD>
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    <TD valign="top"><FONT size="2">Exhibit&nbsp;23.2</FONT></TD>
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Consent of Ernst &#038; Young LLP, filed herewith.</FONT></TD>
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    <TD valign="top"><FONT size="2">Exhibit&nbsp;24</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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Powers of Attorney of certain officers and directors of
EntreMed, Inc.</FONT></TD>
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[{"type": "S-8", "sequence": "1", "filename": "w66274sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 23965}]
{"company-data": {"conformed-name": "ENTREMED INC", "cik": "0000895051", "assigned-sic": "2836", "irs-number": "581959440", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-101617", "film-number": "02847347"}, "business-address": {"street1": "9640 MEDICAL CNTR DR", "street2": "STE 200", "city": "ROCKVILLE", "state": "MD", "zip": "20850", "phone": "3012179858"}, "mail-address": {"street1": "9640 MEDICAL CNTR SR", "street2": "STE 200", "city": "ROCKVILLE", "state": "MD", "zip": "20850"}}
sv8
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
______
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
ENTREMED, INC.
(Exact Name of registrant as specified in its charter)
Delaware
58-1959440
(State or other jurisdiction of
(I.R.S. Employer
incorporation or organization)
Identification No.)
9640 Medical Center Drive
Rockville, Maryland  20850
(Address, including zip code, of principal executive offices)
EntreMed, Inc. 2001 Long-Term Incentive Plan
(Full title of the plan)
John W. Holaday, Ph.D.
EntreMed, Inc.
9640 Medical Center Drive
Rockville, Maryland 20850
(240) 864-2600
(Name, address, including zip code, and telephone number including area code, of agent for service)
Copy to:
Richard E. Baltz, Esq.
Arnold & Porter
555 12th Street, N.W.
Washington, D.C. 20004
(202) 942-5124
______
Calculation of Registration Fee
Proposed maximum
Proposed maximum
Title of securities
Amount to be
offering price per
aggregate offering
Amount of
to be registered
registered (1)
unit (2)(3)
price (3)
registration fee
Common Stock,
$.01 par value
1,000,000
$
1.455
$
1,455,000
$
133.86
(1)
Pursuant to Rule 416, promulgated under the Securities Act of 1933, as
amended, an additional undeterminable number of shares of Common Stock is
being registered to cover any adjustment in the number of shares of Common
Stock issuable pursuant to the anti-dilution provisions of the 2001
Long-Term Incentive Plan.
(2)
Calculated on the basis of the average of the high and low sale prices of
the Registrant's Common Stock as reported on November 22, 2002 on the
Nasdaq National Market which date is within 5 business days prior to the
date of the filing of this Registration Statement.
(3)
Estimated solely for the purpose of determining the registration fee in
accordance with Rule 457(h).
EXPLANATORY NOTE AND INCORPORATION BY REFERENCE
This Registration Statement registers additional shares of EntreMed,
Inc.'s (the "Company") common stock, $.01 par value per share (the "Common
Stock"), issuable under the Company's 2001 Long-Term Incentive Plan (the
"Plan"). The Company previously filed a Registration Statement on Form S-8
with the Securities and Exchange Commission (File No. 333-68048) registering
2,250,000 shares of its Common Stock issuable under the Plan (the "Original
Registration Statement"). On June 24, 2002, the stockholders of the Company
approved an amendment to the Plan that increases by 1,000,000 shares the total
number of shares of Common Stock available for grant or award thereunder.
In accordance with General Instruction E to Form S-8, except as set forth
below, the contents of the Original Registration Statement are incorporated by
reference herein.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference
.
The following documents filed by EntreMed, Inc. ("Registrant" or
"Company") (File No. 000-20713) with the Securities and Exchange Commission
("SEC") under the Securities Exchange Act of 1934, as amended ("Exchange Act"),
are incorporated herein by reference:
(a)
The Company's Annual Report on Form 10-K for the year ended December 31,
2001, filed with the Commission on March 12, 2002; and on Form 10-K/A for the
year ended December 31, 2001, filed with the Commission on March 18, 2002.
(b)
The Company's Quarterly Reports on Form 10-Q for the quarter ended
September 30, 2002, filed with the Commission on November 14, 2002; on
Form 10-Q for the quarter ended June 30, 2002, filed with the Commission
on August 14, 2002 and on Form 10-Q/A for the Quarter ended June 30, 2001,
filed with the Commission on March 15, 2002; on Form 10-Q for the quarter
ended March 31, 2002, filed with the Commission on May 15, 2002; and on Form
10-Q/A for the Quarter ended June 30, 2001, filed with the Commission on
March 15, 2002.
(c)
The description of the common stock of the Company, par value $0.01 per
share ("Common Stock"), contained in a registration statement Form 8-A
filed with the Commission on May 14, 1996, and any amendments or reports
filed for the purpose of updating such description.
All documents filed by the Registrant after the date of this Registration
Statement pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act,
prior to the filing of a post-effective amendment which indicates that all
Common Stock offered hereby has been sold or which deregisters such Common
Stock then remaining unsold, shall be deemed to be incorporated in this
Registration Statement by reference and shall be a part hereof from the date of
filing of such documents. Any statement contained in a document incorporated
or deemed to be incorporated by reference in this Registration Statement shall
be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein or in any other
subsequently filed document which also is or is deemed to be incorporated by
reference in this Registration Statement modifies or supersedes such statement.
Any such statement so modified or superseded shall not be deemed, except as so
modified or so superseded, to constitute a part of this Registration Statement.
Item 8.
Exhibits
Exhibit 4
EntreMed, Inc. 2001 Long-Term Incentive Plan, as amended.
Exhibit 5
Opinion of Arnold & Porter, filed herewith.
Exhibit 23.1
Consent of Arnold & Porter, included in the opinion filed as Exhibit 5 hereto.
Exhibit 23.2
Consent of Ernst & Young LLP, filed herewith.
Exhibit 24
Powers of Attorney of certain officers and directors of EntreMed, Inc.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the Company certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned thereunto
duly authorized in the City of Rockville, State of Maryland, on November 27,
2002.
ENTREMED, INC.
By:
/s/ Neil J. Campbell
Pursuant to the requirements of the Securities Act of 1933, as amended,
this registration statement has been signed by the following persons in the
capacities and on the dates indicated:
Signature
Title
Date
/s/ Neil J. Campbell
Neil J. Campbell
President and Chief
Operating Officer
(principal executive
officer)
November 27, 2002
*
Dane Saglio
Principal Accounting and
Financial Officer
November 27, 2002
/s/ John H. Holaday
John H. Holaday
Chairman of the Board and
Chief Science Officer
November 27, 2002
*
Wendell M. Starke
Vice Chairman of the Board
and Director
November 27, 2002
*
Donald S. Brooks
Director
November 27, 2002
*
Jerry Finkelstein
Director
November 27, 2002
Jennie C. Hunter-Cevera
Director
November 27, 2002
*
Peter S. Knight
Director
November 27, 2002
*
Mark C.M. Randall
Director
November 27, 2002
*
By:
/s/ John W. Holaday, Ph.D.
John
W. Holaday, Ph.D.
Attorney-in-Fact
INDEX TO EXHIBITS
Exhibit 4
EntreMed, Inc. 2001 Long-Term Incentive Plan, as amended, filed herewith.
Exhibit 5
Opinion of Arnold & Porter, filed herewith.
Exhibit 23.1
Consent of Arnold & Porter, included in the opinion filed as Exhibit 5 hereto.
Exhibit 23.2
Consent of Ernst & Young LLP, filed herewith.
Exhibit 24
Powers of Attorney of certain officers and directors of
EntreMed, Inc.