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<TITLE>sv8</TITLE>
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<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV align="right" style="font-size: 10pt; margin-top: 12pt">
<B>As filed with the Securities and Exchange Commission on June 24, 2008</B>
</DIV>


<DIV align="right" style="font-size: 10pt; margin-top: 1pt"><B>Registration No.&nbsp;333-______</B>
</DIV>


<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>


<DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B>
</DIV>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>

<DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM S-8</B>
</DIV>


<DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>REGISTRATION STATEMENT<BR>
Under<BR>
THE SECURITIES ACT OF 1933</B>
</DIV>

<DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>NORTHWEST BIOTHERAPEUTICS, INC.</B>
</DIV>

<DIV align="center" style="font-size: 10pt"><B>(Exact name of registrant as specified in its charter)</B></DIV>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>
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<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top"><B>Delaware</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>94-3306718</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>(State or other jurisdiction of</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>(I.R.S. Employer Identification Number)</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>incorporation or organization)</B></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>7600 Wisconsin Ave., Suite&nbsp;750</B></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>Bethesda, Maryland</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>20814</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>(Address of principal executive offices)</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>(Zip Code)</B></TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>

<DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B>NORTHWEST
BIOTHERAPEUTICS, INC.<br>
2007 STOCK OPTION PLAN</B>
</DIV>

<DIV align="center" style="font-size: 10pt"><B>(Full title of the plan)</B></DIV>


<DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>
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<TR valign="bottom">
    <TD align="center" valign="top"><B>Alton L. Boynton, Chief Executive Officer</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>Copy to:</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>7600 Wisconsin Avenue, Suit 750</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>David H. Engvall, Esq.</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>Bethesda, Maryland 20814</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>Covington &#038; Burling LLP</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>(240)&nbsp;497-9024</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>1201 Pennsylvania Avenue, N.W.</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>(Name, address, including zip code, and</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>Washington, D.C. 20004</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>telephone number, including area code, of</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>(202)&nbsp;662-6000</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><B>agent for service)</B></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
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</TABLE>
</DIV>

<DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a
non-accelerated filer, or a smaller reporting company. See the definitions of &#147;large accelerated
filer,&#148; &#147;accelerated filer&#148; and &#147;smaller reporting company&#148; in Rule&nbsp;12b-2 of the Exchange Act.
(Check one):
</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="50%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="48%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Large accelerated filer <FONT face="Wingdings">&#111;</FONT>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Accelerated filer <FONT face="Wingdings">&#111;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Non-accelerated filer <FONT face="Wingdings">&#111;</FONT> (Do not check if a smaller reporting company)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Smaller reporting company <FONT face="Wingdings">&#254;</FONT></TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>CALCULATION OF REGISTRATION FEE</B>
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="52%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="9%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Proposed maximum</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Proposed maximum</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Amount to be</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">offering price per</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">aggregate offering</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">Amount of</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left">Title of securities to be registered</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">registered (1)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">share (2)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">price (2)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">registration fee</TD>
</TR>


<!-- End Table Head -->
<!-- Begin Table Body -->
<TR style="font-size: 1px">
    <TD colspan="13" valign="top" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Common Stock (3)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top" nowrap>519,132(3)
</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" valign="top">$</TD>
    <TD align="right" valign="top">1.93</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" valign="top">$</TD>
    <TD align="right" valign="top">1,001,925</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top" nowrap>$39.38(3)</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">(1)&nbsp;This Registration Statement shall also cover any additional shares of the Registrant&#146;s Common
Stock that become issuable in respect of the securities identified in the table by reason of any
stock dividend, stock split, recapitalization or other similar transaction effected without the
Registrant&#146;s receipt of consideration which results in an increase in the number of outstanding
shares of the Registrant&#146;s Common Stock.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">(2)&nbsp;Estimated solely for the purpose of calculating the amount of the registration fee pursuant to
Rule 457(c) of the Securities Act of 1933. The price per share and aggregate offering price are
based upon the average bid and ask price of the Registrant&#146;s Common Stock as quoted on the OTC
Bulletin Board on June&nbsp;18, 2008.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">(3)&nbsp;An aggregate of 6,000,000 shares of the Registrant&#146;s Common Stock may be issued under the
Registrant&#146;s 2007 Stock Option Plan, 5,480,868 of which previously were registered on Form S-8
(File No.&nbsp;333-147579) and 519,132 of which are registered by this Form S-8. Pursuant to General
Instruction E to Form S-8, a filing fee is only being paid with respect to the registration of the
519,132 shares of the Registrant&#146;s Common Stock registered hereunder.
</DIV>


<DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>









<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">








<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>REGISTRATION OF ADDITIONAL SECURITIES</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement on Form S-8 is filed by Northwest Biotherapeutics, Inc. (the
&#147;Registrant&#148;) relating to 519,132 shares of its common stock, par value $0.001 per share (&#147;Common
Stock&#148;), issuable under the Northwest Biotherapeutics, Inc. 2007 Stock Option Plan (the &#147;Plan&#148;).
The shares of Common Stock registered hereby are in addition to the 5,480,868 shares of Common
Stock registered on the Registrant&#146;s Registration Statement on Form S-8 (File No.&nbsp;333-147579) (the
&#147;Prior Registration Statement&#148;).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration
Statement are incorporated herein by this reference and made part of this Registration Statement as
though such contents were set forth herein in their entirety, except as amended hereby.
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Part II</B>
</DIV>


<DIV align="Center" style="font-size: 10pt; margin-top: 6pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>

</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exhibits.</B>
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="5%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="93%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Northwest Biotherapeutics, Inc. 2007 Stock Option Plan (Incorporated by reference to Exhibit
10.5 of the Registrant&#146;s Current Report on Form&nbsp;8-K filed with the Securities and Exchange
Commission on June&nbsp;22, 2007).</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Counsel.</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">10.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Form of Stock Option Agreement under the Northwest Biotherapeutics, Inc. 2007 Stock Option
Plan (Incorporated by reference to Exhibit&nbsp;10.2 of the Registrant&#146;s Registration Statement on
Form&nbsp;S-8 (File No.&nbsp;333-147579), filed with the Securities and Exchange Commission on November&nbsp;21, 2007).</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Counsel (Included in Exhibit&nbsp;5.1).</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Independent Registered Public Accounting Firm.</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (included as part of the signature page to this Registration Statement).</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>SIGNATURES</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
has duly caused this registration statement to be signed on its behalf by the undersigned,
thereunto duly authorized in the City of Bethesda, State of Maryland, on June&nbsp;20, 2008.
</DIV>

<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">NORTHWEST BIOTHERAPEUTICS, INC.<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">                                           /s/ ANTHONY P. DEASEY
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">Anthony P. Deasey&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">Senior Vice President of Finance and Chief
Financial Officer
(Principal Financial and Accounting Officer)&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>

</TABLE>

<P align="center" style="font-size: 10pt"><!-- Folio -->2<!-- /Folio -->
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>

</TABLE>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>POWER OF ATTORNEY</B>
</DIV>



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We, the undersigned directors and officers of Northwest Biotherapeutics, Inc. (the &#147;Company&#148;)
hereby severally constitute and appoint Anthony P. Deasey, as our true and lawful attorney and
agent, to do any and all things in our names in the capacities indicated below which said Anthony
P. Deasey may deem necessary or advisable to enable the Company to comply with the Securities Act
of 1933, and any rules, regulations and requirements of the Securities and Exchange Commission, in
connection with the registration of shares of Common Stock to be issued upon the exercise of stock
options to be granted under the Northwest Biotherapeutics, Inc. 2007 Stock Option Plan, including
specifically, but not limited to, power and authority to sign for us in our names in the capacities
indicated below the registration statement and any and all amendments (including post-effective
amendments) thereto; and we hereby approve, ratify and confirm all that said Anthony P. Deasey
shall do or cause to be done by virtue thereof. The undersigned hereby revoke the powers of
attorney granted by each of them to Alton L. Boynton under the Registrant&#146;s registration statement
on Form S-8 (File No.&nbsp;333-147579).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities and on the dates indicated below.
</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="40%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="40%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="14%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
</TR>


<!-- End Table Head -->
<!-- Begin Table Body -->

<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>




<TR valign="bottom">
    <TD align="left" nowrap valign="top">/s/ Alton L. Boynton
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Alton L. Boynton, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
President, Chief Executive Officer
and Director<br>
(Principal Executive Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 23, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Anthony P. Deasey
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Anthony P. Deasey</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Senior Vice President of Finance and<br>
Chief Financial Officer<br>
(Principal Financial and Accounting
Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 23, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ R. Steve Harris
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
R. Steve Harris</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 23, 2008</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Linda F. Powers
<DIV style="font-size: 1pt; border-bottom: 1px solid #000000">&nbsp;</DIV>
Linda F. Powers</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 23, 2008</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->3<!-- /Folio -->
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>EXHIBIT INDEX</B>
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="5%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="93%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Northwest Biotherapeutics, Inc. 2007 Stock Option Plan (Incorporated by reference to Exhibit
10.5 of the Registrant&#146;s Current Report on Form&nbsp;8-K filed with the Securities and Exchange
Commission on June&nbsp;22, 2007).</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Counsel.</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">10.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Form of Stock Option Agreement under the Northwest Biotherapeutics, Inc. 2007 Stock Option
Plan (Incorporated by reference to Exhibit&nbsp;10.2 of the Registrant&#146;s Registration Statement on
Form&nbsp;S-8 (File No.&nbsp;333-147579), filed with the Securities and Exchange Commission on November
21, 2007).</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Counsel (Included in Exhibit&nbsp;5.1).</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Independent Registered Public Accounting Firm.</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (included as part of the signature page to this Registration Statement).</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



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</HTML>
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sv8
As filed with the Securities and Exchange Commission on June 24, 2008
Registration No. 333-______
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
THE SECURITIES ACT OF 1933
NORTHWEST BIOTHERAPEUTICS, INC.
(Exact name of registrant as specified in its charter)
Delaware
94-3306718
(State or other jurisdiction of
(I.R.S. Employer Identification Number)
incorporation or organization)
7600 Wisconsin Ave., Suite 750
Bethesda, Maryland
20814
(Address of principal executive offices)
(Zip Code)
NORTHWEST
BIOTHERAPEUTICS, INC.
2007 STOCK OPTION PLAN
(Full title of the plan)
Alton L. Boynton, Chief Executive Officer
Copy to:
7600 Wisconsin Avenue, Suit 750
David H. Engvall, Esq.
Bethesda, Maryland 20814
Covington & Burling LLP
(240) 497-9024
1201 Pennsylvania Avenue, N.W.
(Name, address, including zip code, and
Washington, D.C. 20004
telephone number, including area code, of
(202) 662-6000
agent for service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a
non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated
filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act.
(Check one):
Large accelerated filer
o
Accelerated filer
o
Non-accelerated filer
o
(Do not check if a smaller reporting company)
Smaller reporting company
þ
CALCULATION OF REGISTRATION FEE
Proposed maximum
Proposed maximum
Amount to be
offering price per
aggregate offering
Amount of
Title of securities to be registered
registered (1)
share (2)
price (2)
registration fee
Common Stock (3)
519,132(3)
$
1.93
$
1,001,925
$39.38(3)
(1) This Registration Statement shall also cover any additional shares of the Registrant's Common
Stock that become issuable in respect of the securities identified in the table by reason of any
stock dividend, stock split, recapitalization or other similar transaction effected without the
Registrant's receipt of consideration which results in an increase in the number of outstanding
shares of the Registrant's Common Stock.
(2) Estimated solely for the purpose of calculating the amount of the registration fee pursuant to
Rule 457(c) of the Securities Act of 1933. The price per share and aggregate offering price are
based upon the average bid and ask price of the Registrant's Common Stock as quoted on the OTC
Bulletin Board on June 18, 2008.
(3) An aggregate of 6,000,000 shares of the Registrant's Common Stock may be issued under the
Registrant's 2007 Stock Option Plan, 5,480,868 of which previously were registered on Form S-8
(File No. 333-147579) and 519,132 of which are registered by this Form S-8. Pursuant to General
Instruction E to Form S-8, a filing fee is only being paid with respect to the registration of the
519,132 shares of the Registrant's Common Stock registered hereunder.
REGISTRATION OF ADDITIONAL SECURITIES
This Registration Statement on Form S-8 is filed by Northwest Biotherapeutics, Inc. (the
"Registrant") relating to 519,132 shares of its common stock, par value $0.001 per share ("Common
Stock"), issuable under the Northwest Biotherapeutics, Inc. 2007 Stock Option Plan (the "Plan").
The shares of Common Stock registered hereby are in addition to the 5,480,868 shares of Common
Stock registered on the Registrant's Registration Statement on Form S-8 (File No. 333-147579) (the
"Prior Registration Statement").
Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration
Statement are incorporated herein by this reference and made part of this Registration Statement as
though such contents were set forth herein in their entirety, except as amended hereby.
Part II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 8.          Exhibits.
4.1
Northwest Biotherapeutics, Inc. 2007 Stock Option Plan (Incorporated by reference to Exhibit
10.5 of the Registrant's Current Report on Form 8-K filed with the Securities and Exchange
Commission on June 22, 2007).
5.1
Opinion of Counsel.
10.1
Form of Stock Option Agreement under the Northwest Biotherapeutics, Inc. 2007 Stock Option
Plan (Incorporated by reference to Exhibit 10.2 of the Registrant's Registration Statement on
Form S-8 (File No. 333-147579), filed with the Securities and Exchange Commission on November 21, 2007).
23.1
Consent of Counsel (Included in Exhibit 5.1).
23.2
Consent of Independent Registered Public Accounting Firm.
24.1
Power of Attorney (included as part of the signature page to this Registration Statement).
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
has duly caused this registration statement to be signed on its behalf by the undersigned,
thereunto duly authorized in the City of Bethesda, State of Maryland, on June 20, 2008.
NORTHWEST BIOTHERAPEUTICS, INC.
By:
/s/ ANTHONY P. DEASEY
Anthony P. Deasey
Senior Vice President of Finance and Chief
Financial Officer
(Principal Financial and Accounting Officer)
2
POWER OF ATTORNEY
We, the undersigned directors and officers of Northwest Biotherapeutics, Inc. (the "Company")
hereby severally constitute and appoint Anthony P. Deasey, as our true and lawful attorney and
agent, to do any and all things in our names in the capacities indicated below which said Anthony
P. Deasey may deem necessary or advisable to enable the Company to comply with the Securities Act
of 1933, and any rules, regulations and requirements of the Securities and Exchange Commission, in
connection with the registration of shares of Common Stock to be issued upon the exercise of stock
options to be granted under the Northwest Biotherapeutics, Inc. 2007 Stock Option Plan, including
specifically, but not limited to, power and authority to sign for us in our names in the capacities
indicated below the registration statement and any and all amendments (including post-effective
amendments) thereto; and we hereby approve, ratify and confirm all that said Anthony P. Deasey
shall do or cause to be done by virtue thereof. The undersigned hereby revoke the powers of
attorney granted by each of them to Alton L. Boynton under the Registrant's registration statement
on Form S-8 (File No. 333-147579).
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities and on the dates indicated below.
Signature
Title
Date
/s/ Alton L. Boynton
Alton L. Boynton, Ph.D.
President, Chief Executive Officer
and Director
(Principal Executive Officer)
June 23, 2008
/s/ Anthony P. Deasey
Anthony P. Deasey
Senior Vice President of Finance and
Chief Financial Officer
(Principal Financial and Accounting
Officer)
June 23, 2008
/s/ R. Steve Harris
R. Steve Harris
Director
June 23, 2008
/s/ Linda F. Powers
Linda F. Powers
Director
June 23, 2008
3
EXHIBIT INDEX
4.1
Northwest Biotherapeutics, Inc. 2007 Stock Option Plan (Incorporated by reference to Exhibit
10.5 of the Registrant's Current Report on Form 8-K filed with the Securities and Exchange
Commission on June 22, 2007).
5.1
Opinion of Counsel.
10.1
Form of Stock Option Agreement under the Northwest Biotherapeutics, Inc. 2007 Stock Option
Plan (Incorporated by reference to Exhibit 10.2 of the Registrant's Registration Statement on
Form S-8 (File No. 333-147579), filed with the Securities and Exchange Commission on November
21, 2007).
23.1
Consent of Counsel (Included in Exhibit 5.1).
23.2
Consent of Independent Registered Public Accounting Firm.
24.1
Power of Attorney (included as part of the signature page to this Registration Statement).
4