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<P align="center">As filed with the Securities and Exchange Commission on February&nbsp;23, 2001


<P align="right">Registration No.&nbsp;333-_____

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<P align="center"><B>SECURITIES AND EXCHANGE COMMISSION<BR>
WASHINGTON, D.C. 20549</B>

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<P align="center"><B>FORM S-8<BR>
REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</B>

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<P align="center"><B>GUILFORD PHARMACEUTICALS INC.<BR>
(Exact name of Registrant as specified in its charter)</B>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="95%" align="center">
<TR valign="bottom">
        <TD width="34%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="30%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="30%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD align="center" valign="top"><FONT size="2">DELAWARE<BR>
(State or other jurisdiction of<BR>
Incorporation or organization)</FONT></TD>
        <TD></TD>
        <TD  align="center" valign="top"><FONT size="2">
6611 TRIBUTARY STREET<BR>
BALTIMORE, MARYLAND 21224<BR>
(Address of principal executive offices)(Zip code)
</FONT></TD>
        <TD></TD>
        <TD  align="center" valign="top"><FONT size="2">52-1841960<BR>
(I.R.S. Employer<BR>
Identification Number)</FONT></TD>
</TR>
</TABLE>
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<P align="center"><B>1993 EMPLOYEE SHARE OPTION AND RESTRICTED SHARE PLAN<BR>
SHARE OPTION AGREEMENT (SUSAN SMITH)<BR>
(Full Title of the plan)</B>

<P align="center"><B>CRAIG R. SMITH, M.D.<BR>
CHIEF EXECUTIVE OFFICER, PRESIDENT AND CHAIRMAN OF THE BOARD<BR>
GUILFORD PHARMACEUTICALS INC.<BR>
6611 TRIBUTARY STREET<BR>
BALTIMORE, MARYLAND 21224<BR>
(Name and address of agent for service)</B>

<P align="center"><B>(410)&nbsp;631-6300<BR>
(Telephone Number, including area code, of agent for service)</B>
<P>
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<Center><B>WITH A COPY TO:<BR>
MICHAEL J. SILVER, ESQ.<BR>
HOGAN &#38; HARTSON L.L.P.<BR>
111 SOUTH CALVERT STREET<BR>
BALTIMORE, MARYLAND 21202<BR>
(410)&nbsp;659-2700</B></Center>
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<P align="center"><B>CALCULATION OF REGISTRATION FEE</B>

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<TABLE cellspacing="0" border="0" cellpadding="0" width="65%" align="center">
<TR valign="bottom">
        <TD width="30%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="8%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="8%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
</TR>

<TR valign="bottom">
        <TD nowrap align="center" colspan="19"><FONT size="2"><hr noshade></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="5"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2"><B>Proposed maximum</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2"><B>Proposed maximum</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2"><B>Amount of</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"><B>Title of Securities</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="5"><FONT size="2"><B>Amount to be</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2"><B>offering price per</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2"><B>aggregate offering</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2"><B>registration</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"><B>to be registered</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="5"><FONT size="2"><B>registered (1)</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2"><B>share (1)</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2"><B>price (1)</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2"><B>fee(1)</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1"></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="5"><HR size="1"></TD>
        <TD></TD>
        <TD colspan="3"><HR size="1"></TD>
        <TD></TD>
        <TD colspan="3"><HR size="1"></TD>
        <TD></TD>
        <TD colspan="3"><HR size="1"></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">Common Stock, par value
$.01 per share, and Series
A Junior Participation
Preferred Share Purchase
Rights
</FONT></TD>
        <TD></TD>
        <TD nowrap align="right" valign="top"></TD>
        <TD align="right" valign="top"><FONT size="2">
1,702,175
8,000
</FONT></TD>
        <TD valign="top"></TD>
        <TD></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">(a)<BR>
(b)
</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
19.40625
16.0625
</FONT></TD>
        <TD nowrap align="right" valign="top"></TD>
        <TD align="right" valign="top"><FONT size="2">
</FONT></TD>
        <TD valign="top"></TD>
        <TD></TD>

<TD  align="left" valign="top"><FONT size="2">$33,032,834.00<br>
$128,500.00<br><br><br><br><br><br><br>Total Fee:
</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top" NOWRAP><FONT size="2">
$ 8,259.00<br>
$ 33.00 <br>
<br><br><br><br><br><br>
$ 8,292.00
</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2"></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center" colspan="19"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="left" valign="top"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
</TR>

<TR valign="bottom">
        <TD nowrap align="center" colspan="19"><FONT size="2"><hr size=1></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="left" valign="top"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"></FONT></TD>
</TR>

</TABLE>
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<p>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
      <TD width="1%" align="left">(1)</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="96%">Pursuant to Rule&nbsp;457(h)(1), the proposed maximum offering price
per share, proposed maximum aggregate offering price and the
amount of the registration fee are based on (a)&nbsp;the
average of the bid and asked price of $19.40625 per share of Guilford
Pharmaceuticals Inc. common stock on February 16, 2001 as reported on
the NASDAQ National Market and (b)&nbsp;the exercise price of $16.0625 per share
of the 8,000 shares issuable upon exercise of options under the
Share Option Agreement (Susan Smith).</TD>
</TR>
</TABLE>

<P align="center">&nbsp;
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<P align="center"><B>REGISTRATION OF ADDITIONAL SECURITIES</B>

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with Section&nbsp;E of the General Instructions to Form&nbsp;S-8, the
contents of Form&nbsp;S-8, Registration No.&nbsp;33-90828, filed by Guilford
Pharmaceuticals Inc. (the &#147;Registrant&#148;) with the Securities and Exchange
Commission on March&nbsp;31, 1995, are incorporated herein by reference for the
registration of 1,702,175 shares of additional securities issuable pursuant to
the Guilford Pharmaceuticals Inc. 1993 Employee Share Option and Restricted
Share Plan, as amended.

<P align="center"><B>PART I</B>

<P align="center"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Guilford Pharmaceuticals Inc. (the &#147;Registrant&#148;) will separately send or
give documents containing the information required to be provided in this Part I
to each person eligible to participate in the Guilford Pharmaceuticals Inc. 1993
Employee Shares and Restricted Share Plan, as amended, and the Share Option
Agreement (Susan Smith) as specified by Rule&nbsp;428(b)(1). In accordance with the
instructions to Part I of Form&nbsp;S-8, the Registrant will not file these documents
with the Securities and Exchange Commission, either as part of this registration
statement or as prospectuses or prospectus supplements pursuant to Rule&nbsp;424
under the Securities Act of 1933.

<P align="center"><B>PART II</B>

<P align="center"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>

<P align="left"><B>ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.</B>

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant hereby incorporates by reference into this registration
statement the following documents:

<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="3%"></TD>
        <TD width="97%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>(a)&nbsp;Annual report on Form&nbsp;10-K for the year ended December&nbsp;31, 1999 filed
with the SEC on March&nbsp;30, 2000.</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="3%"></TD>
        <TD width="97%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>(b)&nbsp;All reports filed with the Commission pursuant
to Section&nbsp;13(a) or 15(d) of the Securities Exchange Act of<br>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1934, as amended, since December&nbsp;31,
1999.</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="3%"></TD>
        <TD width="97%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>(c)&nbsp;The description of the Registrant&#146;s common stock contained in the
Registrant&#146;s registration statement on<br>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Form&nbsp;8-A
filed with the Commission on March&nbsp;25, 1994, registering shares
of Common Stock<br>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;pursuant to Section&nbsp;12(g) of the
 Exchange Act of 1934.</TD>
</TR>
</TABLE>
<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In addition, all documents subsequently filed by the Registrant pursuant to
Section&nbsp;13(a), 13(c), 14, or 15(d) of the Exchange Act of 1934, prior to the
filing of a post-effective amendment which indicates that all securities offered
have been sold or which deregisters all securities remaining unsold, shall be
deemed to be incorporated by reference in this registration statement and to be
part of hereof from the date of the filing of such documents.

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any statement contained in a document incorporated or deemed to be
incorporated by reference shall be deemed to be modified or superseded to the
extent that a statement contained in any other subsequently filed document which
also is or is deemed to be incorporated by reference herein modifies or
supersedes such prior statement. The documents required to be so modified or
superseded shall not be deemed to constitute a part of this registration
statement, except as so modified or superseded.

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To the extent that any proxy statement is incorporated by reference herein,
such incorporation shall not include any information contained in such proxy
statement which is not, pursuant to the Commission&#146;s rules, deemed to be &#147;filed&#148;
with the Commission or subject to the liabilities of Section&nbsp;18 of the Exchange
Act of 1934.


<P align="center">&nbsp;
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<P align="left"><B>ITEM 4. DESCRIPTION OF SECURITIES.</B>

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A description of the Registrant&#146;s common stock, par value $ .01 per share,
is incorporated by reference under Item&nbsp;3.

<P align="left"><B>ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.</B>

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Not applicable.</B>

<P align="left"><B>ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.</B>

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Under Section&nbsp;145 of the Delaware General Corporation Law (&#147;DGCL&#148;), the
Registrant has broad powers to indemnify its directors and officers against
liabilities they may incur in such capacities, including liabilities under the
Securities Act of 1933. Article&nbsp;Nine of the Registrant&#146;s Amended and Restated
Certificate of Incorporation provides that the Company will indemnify its
directors and officers to the full extent permitted by law and that no director
shall be liable for monetary damages to the Registrant or its stockholders for
any breach of fiduciary duty, except to the extent provided by applicable law
(i)&nbsp;for any breach of the director&#146;s duty of loyalty to the Registrant or its
stockholders, (ii)&nbsp;for acts or omissions not in good faith or which involve
intentional misconduct or a knowing violation of law, (iii)&nbsp;pursuant to Section
174 of the DGCL or (iv)&nbsp;for any transaction from which such director derived an
improper personal benefit. In addition, under indemnification agreements with
its directors and officers, the Registrant is obligated, to the fullest extent
permissible by the DGCL, as it currently exists or may be amended, to indemnify
and hold harmless its directors and officers, from and against all expense,
liability and loss reasonably incurred or suffered by such directors and
officers.

<P align="center"><B>*  *  *  *  *</B>

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to trustees, officers, and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Commission such indemnification is
against public policy as expressed in the Securities Act of 1933 and is,
therefore, unenforceable. In the event that a claim for indemnification against
such liabilities (other than the payment by the Registrant of the expenses
incurred or paid by a trustee, officer or controlling person of the Registrant
of the successful defense of any action, suit or proceeding) is asserted by such
trustee, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of counsel the matter has
been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by the Registrant is
against public policy as expressed in the Securities Act of 1933 and will be
governed by the final adjudication of such issue.

<P align="left"><B>ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.</B>

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Not applicable.</B>

<P align="left"><B>ITEM 8. EXHIBITS.</B>

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<TABLE cellspacing="0" border="0" cellpadding="0" width="65%" align="center">
<TR valign="bottom">
        <TD width="10%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="85%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"><B>EXHIBIT</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"><B>NUMBER</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"><B>DESCRIPTION</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1"></TD>
        <TD></TD>
        <TD nowrap align="center"><HR size="1"></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1(a)</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Guilford Pharmaceuticals Inc. 1993 Employee Share Option and
Restricted Share Plan (as amended)</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1(b)</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Share Option Agreement (Susan Smith)</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1(c)</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Amendment to Guilford Pharmaceuticals Inc. Amended and Restated 1993
Employee Share Option and Restricted Share Plan, as Amended</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center">&nbsp;
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<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="65%" align="center">
<TR valign="bottom">
        <TD width="10%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="85%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"></TD>
        <TD></TD>
        <TD nowrap align="center"></TD>
</TR>

<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">5</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Opinion of Hogan &#38; Hartson L.L.P. regarding the legality of
the shares of common stock being registered</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"></TD>
        <TD></TD>
        <TD nowrap align="center"></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.1</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Consent of Hogan &#38; Hartson L.L.P. (contained in Exhibit&nbsp;5)</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"></TD>
        <TD></TD>
        <TD nowrap align="center"></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.2</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Consent of KPMG LLP (filed herewith)</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"></TD>
        <TD></TD>
        <TD nowrap align="center"></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">24</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Power of Attorney (contained on signature page)</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="left"><B>ITEM 9. UNDERTAKINGS.</B>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="3%"></TD>
        <TD width="97%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;The undersigned Registrant hereby undertakes:
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="6%"></TD>
        <TD width="94%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To file, during any period in which offers or sales are being made,
a post-effective amendment to this <BR>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;registration statement:</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="9%"></TD>
        <TD width="3%"></TD>
        <TD width="88%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>(i)</TD>
<td>
To include any prospectus required by Section&nbsp;10(a)(3) of the
Securities Act of 1933;</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="9%"></TD>
        <TD width="3%"></TD>
        <TD width="88%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>(ii)</TD>
        <TD>To reflect in the prospectus any facts or events arising after
the effective date of the registration statement (or the most
recent post-effective amendment thereof) which, individually or
in the aggregate, represent a fundamental change in the
information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in
volume of securities offered (if the total dollar value of
securities offered would not exceed that which was registered)
and any deviation from the low or high end of the estimated
maximum offering range may be reflected in the form of
prospectus filed with the Commission pursuant to Rule&nbsp;424(b) if,
in the aggregate, the changes in volume and price represent no
more than a 20&nbsp;percent change in the maximum aggregate offering
price set forth in the &#147;Calculation of Registration Fee&#148; table
in the effective registration statement;</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="9%"></TD>
        <TD width="3%"></TD>
        <TD width="88%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>(iii)</TD>
        <TD>To include any material information with respect to the plan of
distribution not previously disclosed in the registration
statement or any material change to such information in the
registration statement;</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="6%"></TD>
        <TD width="94%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply
if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or
furnished to the Commission by the Registrant pursuant to Section&nbsp;13 or
Section&nbsp;15(d) of the Exchange Act of 1934 that are incorporated by
reference in this registration statement.</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="6%"></TD>
        <TD width="94%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-<BR>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;effective amendment shall be
deemed to be a new registration statement relating to the securities
offered <BR>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;therein, and the offering of such securities at that time shall
be deemed to be the initial bona fide offering <BR>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;thereof.</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="6%"></TD>
        <TD width="94%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;To remove from registration by means of a post-effective amendment
any of the securities being <BR>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;registered which remain unsold at the
termination of the offering.</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="6%"></TD>
        <TD width="94%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>(b)&nbsp;The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing
of the Registrant&#146;s annual report pursuant to Section&nbsp;13(a) or Section
15(d) of the Exchange Act of 1934 that is incorporated by reference in
this registration statement shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering
of such securities at that time shall be deemed to be the initial bona
fide offering thereof.</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="6%"></TD>
        <TD width="94%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>(c)&nbsp;The undertaking concerning indemnification is set forth under the
response to Item&nbsp;6.</TD>
</TR>
</TABLE>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="6%"></TD>
        <TD width="94%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>(d)&nbsp;The undersigned Registrant hereby undertakes to deliver or cause to be
delivered with the prospectus, to each person to whom the prospectus is
sent or given, the latest annual report, to security holders that is
incorporated by reference in the prospectus and furnished pursuant to
and meeting the requirements of Rule&nbsp;14a-3 or 14c-3 under the Securities
Exchange Act of 1934; and, where interim financial information required
to be presented by Article&nbsp;3 of Regulation&nbsp;S-X is not set forth in the
prospectus, to deliver, or cause to be delivered to each</TD>
</TR>
</TABLE>

<P align="center">&nbsp;
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<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="6%"></TD>
        <TD width="94%"></TD>
</TR>
<TR valign="top">
        <TD>&nbsp;</TD>
        <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;person to whom the prospectus is sent or given, the latest quarterly
report that is specifically incorporated<br>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;by reference in the prospectus
to provide such interim financial information.</TD>
</TR>
</TABLE>

<P align="center">&nbsp;
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<P align="center"><B>EXHIBIT INDEX</B>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="65%" align="center">
<TR valign="bottom">
        <TD width="10%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="85%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"><B>Exhibit</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"><B>Number</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"><B>Description</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1"></TD>
        <TD></TD>
        <TD nowrap align="center"><HR size="1"></TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1(a)</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Guilford Pharmaceuticals Inc. 1993 Employee Share Option and
Restricted Share Plan (as amended).</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1(b)</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Share Option Agreement (Susan Smith)</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">4.1(c)</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Amendment to Guilford Pharmaceuticals Inc. Amended and Restated 1993
Employee Share Option and Restricted Share Plan, as Amended.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">5</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Opinion of Hogan &#38; Hartson L.L.P. regarding the legality of
the shares of common stock being registered</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.1</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Consent of Hogan &#38; Hartson L.L.P. (contained in Exhibit&nbsp;5)</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">23.2</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Consent of KPMG LLP</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top"><FONT size="2">24</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Power of Attorney (contained on signature page)</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center">&nbsp;
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<P align="center"><B>SIGNATURES</B>

<P>Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form&nbsp;S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Baltimore, Maryland, on February&nbsp;23, 2001.

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="75%" align="center">
<TR valign="bottom">
        <TD width="50%">&nbsp;</TD>
        <TD width="50%">&nbsp;</TD>
</TR>
<TR valign="bottom">
     <TD>&nbsp;</TD>
     <TD valign="top"><FONT size="2"><B>Guilford Pharmeceuticals Inc.</B></FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
     <TD>&nbsp;</TD>
        <TD valign="top"><FONT size="2">By: /s/ Craig R. Smith, M.D.</FONT></TD>
</TR>
<TR valign="bottom">
     <TD>&nbsp;</TD>
        <TD valign="top"><FONT size="2">&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;</FONT></TD>
</TR>
<TR valign="bottom">
     <TD>&nbsp;</TD>
        <TD valign="top"><FONT size="2">Craig R. Smith, M.D.<BR>
Chairman of the Board, President<BR>
&nbsp;&nbsp;&nbsp;&nbsp;and Chief Executive Officer</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P>Pursuant to the requirements of the Securities Act of 1933, this registration
statement has been signed by the following persons in the capacities and on the
date indicated.

<P>We, the undersigned officers and directors of Guilford Pharmaceuticals Inc.,
hereby severally and individually constitute and appoint Craig R. Smith, M.D.,
Andrew R. Jordan, Thomas C. Seoh, and Michael J. Silver, and each of them, the
true and lawful attorneys and agents of each of us to execute in the name, place
and stead of each of us (individually and in any capacity stated below) any and
all amendments to this registration statement on Form&nbsp;S-8, and all instruments
necessary or advisable in connection therewith and to file the same with the
Securities and Exchange Commission, each of said attorneys and agents to have
power to act with or without the other and to have full power and authority to
do and perform in the name and on behalf of each of the undersigned every act
whatsoever necessary or advisable to be done in the premises as fully and to all
intents and purposes as any of the undersigned might or could do in person, and
we hereby ratify and confirm our signatures as they may be signed by our said
attorneys and agents and each of them to any and all such amendment and
amendments.

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="75%" align="center">
<TR valign="bottom">
        <TD width="33%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="54%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top">Date:  February 23, 2001</TD>
        <TD></TD>
        <TD  align="left" valign="top">
By:
</TD>
        <TD></TD>
        <TD  align="left" valign="top">/s/ Craig R. Smith, M.D.</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">Craig R. Smith, M.D.<BR>
Chairman of the Board, President<BR>
&nbsp;&nbsp;&nbsp;&nbsp;and Chief Executive Officer<BR>
&nbsp;&nbsp;&nbsp;&nbsp;(Principal Executive Officer)</TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top">Date: February 23, 2001</TD>
        <TD></TD>
        <TD  align="left" valign="top">
By:
</TD>
        <TD></TD>
        <TD  align="left" valign="top">/s/ Andrew R. Jordan</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">Andrew R. Jordan<BR>
Senior Vice President and<BR>
&nbsp;&nbsp;&nbsp;&nbsp;Chief Financial Officer<BR>
(Principal Accounting Officer)</TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top">Date: February 23, 2001</TD>
        <TD></TD>
        <TD  align="left" valign="top">
By:
</TD>
        <TD></TD>
        <TD  align="left" valign="top">/s/ George L. Bunting, Jr.</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">George L. Bunting, Jr.<BR>
Director</TD>
</TR>
</TABLE>
</CENTER>
<P align="center">&nbsp;
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<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="75%" align="center">
<TR valign="bottom">
        <TD width="33%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="54%">&nbsp;</TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top">Date: February 23, 2001</TD>
        <TD></TD>
        <TD  align="left" valign="top">
By:
</TD>
        <TD></TD>
        <TD  align="left" valign="top">/s/ Richard L. Casey</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">Richard L. Casey<BR>
Director</TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top">Date: February 23, 2001</TD>
        <TD></TD>
        <TD  align="left" valign="top">
By:
</TD>
        <TD></TD>
        <TD  align="left" valign="top">/s/ Elizabeth M. Greetham</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">Elizabeth M. Greetham<BR>
Director</TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top">Date: February 23, 2001</TD>
        <TD></TD>
        <TD  align="left" valign="top">
By:
</TD>
        <TD></TD>
        <TD  align="left" valign="top">/s/ Joseph Klein, III</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">Joseph Klein, III<BR>
Director</TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top">Date: February 23, 2001</TD>
        <TD></TD>
        <TD  align="left" valign="top">
By:
</TD>
        <TD></TD>
        <TD  align="left" valign="top">/s/ Ronald M. Nordmann</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">Ronald M. Nordmann<BR>
Director</TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top">Date: February 23, 2001</TD>
        <TD></TD>
        <TD  align="left" valign="top">
By:
</TD>
        <TD></TD>
        <TD  align="left" valign="top">/s/ Solomon H. Snyder, M.D.</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">Solomon H. Snyder, M.D.<BR>
Director</TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
        <TD valign="top">Date: February 23, 2001</TD>
        <TD></TD>
        <TD  align="left" valign="top">
By:
</TD>
        <TD></TD>
        <TD  align="left" valign="top">/s/ W. Leigh Thompson, M.D., Ph.D.</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top"></TD>
        <TD></TD>
        <TD  align="left" valign="top">
</TD>
        <TD></TD>
        <TD  align="left" valign="top">W. Leigh Thompson, M.D., Ph.D.<BR>
Director</TD>
</TR>
</TABLE>
</CENTER>

<P align="center">&nbsp;

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{"company-data": {"conformed-name": "GUILFORD PHARMACEUTICALS INC", "cik": "0000918066", "assigned-sic": "2834", "irs-number": "521841960", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-56092", "film-number": "1552949"}, "business-address": {"street1": "6611 TRIBUTARY ST", "city": "BALTIMORE", "state": "MD", "zip": "21224", "phone": "4106316300"}}
s-8
As filed with the Securities and Exchange Commission on February 23, 2001
Registration No. 333-_____
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
GUILFORD PHARMACEUTICALS INC.
(Exact name of Registrant as specified in its charter)
DELAWARE
(State or other jurisdiction of
Incorporation or organization)
6611 TRIBUTARY STREET
BALTIMORE, MARYLAND 21224
(Address of principal executive offices)(Zip code)
52-1841960
(I.R.S. Employer
Identification Number)
1993 EMPLOYEE SHARE OPTION AND RESTRICTED SHARE PLAN
SHARE OPTION AGREEMENT (SUSAN SMITH)
(Full Title of the plan)
CRAIG R. SMITH, M.D.
CHIEF EXECUTIVE OFFICER, PRESIDENT AND CHAIRMAN OF THE BOARD
GUILFORD PHARMACEUTICALS INC.
6611 TRIBUTARY STREET
BALTIMORE, MARYLAND 21224
(Name and address of agent for service)
(410) 631-6300
(Telephone Number, including area code, of agent for service)
WITH A COPY TO:
MICHAEL J. SILVER, ESQ.
HOGAN & HARTSON L.L.P.
111 SOUTH CALVERT STREET
BALTIMORE, MARYLAND 21202
(410) 659-2700
CALCULATION OF REGISTRATION FEE
Proposed maximum
Proposed maximum
Amount of
Title of Securities
Amount to be
offering price per
aggregate offering
registration
to be registered
registered (1)
share (1)
price (1)
fee(1)
Common Stock, par value
$.01 per share, and Series
A Junior Participation
Preferred Share Purchase
Rights
1,702,175
8,000
(a)
(b)
19.40625
16.0625
$33,032,834.00
$128,500.00
Total Fee:
$ 8,259.00
$ 33.00
$ 8,292.00
(1)
Pursuant to Rule 457(h)(1), the proposed maximum offering price
per share, proposed maximum aggregate offering price and the
amount of the registration fee are based on (a) the
average of the bid and asked price of $19.40625 per share of Guilford
Pharmaceuticals Inc. common stock on February 16, 2001 as reported on
the NASDAQ National Market and (b) the exercise price of $16.0625 per share
of the 8,000 shares issuable upon exercise of options under the
Share Option Agreement (Susan Smith).
REGISTRATION OF ADDITIONAL SECURITIES
In accordance with Section E of the General Instructions to Form S-8, the
contents of Form S-8, Registration No. 33-90828, filed by Guilford
Pharmaceuticals Inc. (the "Registrant") with the Securities and Exchange
Commission on March 31, 1995, are incorporated herein by reference for the
registration of 1,702,175 shares of additional securities issuable pursuant to
the Guilford Pharmaceuticals Inc. 1993 Employee Share Option and Restricted
Share Plan, as amended.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Guilford Pharmaceuticals Inc. (the "Registrant") will separately send or
give documents containing the information required to be provided in this Part I
to each person eligible to participate in the Guilford Pharmaceuticals Inc. 1993
Employee Shares and Restricted Share Plan, as amended, and the Share Option
Agreement (Susan Smith) as specified by Rule 428(b)(1). In accordance with the
instructions to Part I of Form S-8, the Registrant will not file these documents
with the Securities and Exchange Commission, either as part of this registration
statement or as prospectuses or prospectus supplements pursuant to Rule 424
under the Securities Act of 1933.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.
The Registrant hereby incorporates by reference into this registration
statement the following documents:
(a) Annual report on Form 10-K for the year ended December 31, 1999 filed
with the SEC on March 30, 2000.
(b) All reports filed with the Commission pursuant
to Section 13(a) or 15(d) of the Securities Exchange Act of
1934, as amended, since December 31,
1999.
(c) The description of the Registrant's common stock contained in the
Registrant's registration statement on
Form 8-A
filed with the Commission on March 25, 1994, registering shares
of Common Stock
pursuant to Section 12(g) of the
 Exchange Act of 1934.
In addition, all documents subsequently filed by the Registrant pursuant to
Section 13(a), 13(c), 14, or 15(d) of the Exchange Act of 1934, prior to the
filing of a post-effective amendment which indicates that all securities offered
have been sold or which deregisters all securities remaining unsold, shall be
deemed to be incorporated by reference in this registration statement and to be
part of hereof from the date of the filing of such documents.
Any statement contained in a document incorporated or deemed to be
incorporated by reference shall be deemed to be modified or superseded to the
extent that a statement contained in any other subsequently filed document which
also is or is deemed to be incorporated by reference herein modifies or
supersedes such prior statement. The documents required to be so modified or
superseded shall not be deemed to constitute a part of this registration
statement, except as so modified or superseded.
To the extent that any proxy statement is incorporated by reference herein,
such incorporation shall not include any information contained in such proxy
statement which is not, pursuant to the Commission's rules, deemed to be "filed"
with the Commission or subject to the liabilities of Section 18 of the Exchange
Act of 1934.
ITEM 4. DESCRIPTION OF SECURITIES.
A description of the Registrant's common stock, par value $ .01 per share,
is incorporated by reference under Item 3.
ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.
Not applicable.
ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.
Under Section 145 of the Delaware General Corporation Law ("DGCL"), the
Registrant has broad powers to indemnify its directors and officers against
liabilities they may incur in such capacities, including liabilities under the
Securities Act of 1933. Article Nine of the Registrant's Amended and Restated
Certificate of Incorporation provides that the Company will indemnify its
directors and officers to the full extent permitted by law and that no director
shall be liable for monetary damages to the Registrant or its stockholders for
any breach of fiduciary duty, except to the extent provided by applicable law
(i) for any breach of the director's duty of loyalty to the Registrant or its
stockholders, (ii) for acts or omissions not in good faith or which involve
intentional misconduct or a knowing violation of law, (iii) pursuant to Section
174 of the DGCL or (iv) for any transaction from which such director derived an
improper personal benefit. In addition, under indemnification agreements with
its directors and officers, the Registrant is obligated, to the fullest extent
permissible by the DGCL, as it currently exists or may be amended, to indemnify
and hold harmless its directors and officers, from and against all expense,
liability and loss reasonably incurred or suffered by such directors and
officers.
*  *  *  *  *
Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to trustees, officers, and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Commission such indemnification is
against public policy as expressed in the Securities Act of 1933 and is,
therefore, unenforceable. In the event that a claim for indemnification against
such liabilities (other than the payment by the Registrant of the expenses
incurred or paid by a trustee, officer or controlling person of the Registrant
of the successful defense of any action, suit or proceeding) is asserted by such
trustee, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of counsel the matter has
been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by the Registrant is
against public policy as expressed in the Securities Act of 1933 and will be
governed by the final adjudication of such issue.
ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.
Not applicable.
ITEM 8. EXHIBITS.
EXHIBIT
NUMBER
DESCRIPTION
4.1(a)
Guilford Pharmaceuticals Inc. 1993 Employee Share Option and
Restricted Share Plan (as amended)
4.1(b)
Share Option Agreement (Susan Smith)
4.1(c)
Amendment to Guilford Pharmaceuticals Inc. Amended and Restated 1993
Employee Share Option and Restricted Share Plan, as Amended
5
Opinion of Hogan & Hartson L.L.P. regarding the legality of
the shares of common stock being registered
23.1
Consent of Hogan & Hartson L.L.P. (contained in Exhibit 5)
23.2
Consent of KPMG LLP (filed herewith)
24
Power of Attorney (contained on signature page)
ITEM 9. UNDERTAKINGS.
(a) The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this
registration statement:
(i)
To include any prospectus required by Section 10(a)(3) of the
Securities Act of 1933;
(ii)
To reflect in the prospectus any facts or events arising after
the effective date of the registration statement (or the most
recent post-effective amendment thereof) which, individually or
in the aggregate, represent a fundamental change in the
information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in
volume of securities offered (if the total dollar value of
securities offered would not exceed that which was registered)
and any deviation from the low or high end of the estimated
maximum offering range may be reflected in the form of
prospectus filed with the Commission pursuant to Rule 424(b) if,
in the aggregate, the changes in volume and price represent no
more than a 20 percent change in the maximum aggregate offering
price set forth in the "Calculation of Registration Fee" table
in the effective registration statement;
(iii)
To include any material information with respect to the plan of
distribution not previously disclosed in the registration
statement or any material change to such information in the
registration statement;
provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply
if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or
furnished to the Commission by the Registrant pursuant to Section 13 or
Section 15(d) of the Exchange Act of 1934 that are incorporated by
reference in this registration statement.
(2) That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-
effective amendment shall be
deemed to be a new registration statement relating to the securities
offered
therein, and the offering of such securities at that time shall
be deemed to be the initial bona fide offering
thereof.
(3) To remove from registration by means of a post-effective amendment
any of the securities being
registered which remain unsold at the
termination of the offering.
(b) The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing
of the Registrant's annual report pursuant to Section 13(a) or Section
15(d) of the Exchange Act of 1934 that is incorporated by reference in
this registration statement shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering
of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
(c) The undertaking concerning indemnification is set forth under the
response to Item 6.
(d) The undersigned Registrant hereby undertakes to deliver or cause to be
delivered with the prospectus, to each person to whom the prospectus is
sent or given, the latest annual report, to security holders that is
incorporated by reference in the prospectus and furnished pursuant to
and meeting the requirements of Rule 14a-3 or 14c-3 under the Securities
Exchange Act of 1934; and, where interim financial information required
to be presented by Article 3 of Regulation S-X is not set forth in the
prospectus, to deliver, or cause to be delivered to each
person to whom the prospectus is sent or given, the latest quarterly
report that is specifically incorporated
by reference in the prospectus
to provide such interim financial information.
EXHIBIT INDEX
Exhibit
Number
Description
4.1(a)
Guilford Pharmaceuticals Inc. 1993 Employee Share Option and
Restricted Share Plan (as amended).
4.1(b)
Share Option Agreement (Susan Smith)
4.1(c)
Amendment to Guilford Pharmaceuticals Inc. Amended and Restated 1993
Employee Share Option and Restricted Share Plan, as Amended.
5
Opinion of Hogan & Hartson L.L.P. regarding the legality of
the shares of common stock being registered
23.1
Consent of Hogan & Hartson L.L.P. (contained in Exhibit 5)
23.2
Consent of KPMG LLP
24
Power of Attorney (contained on signature page)
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Baltimore, Maryland, on February 23, 2001.
Guilford Pharmeceuticals Inc.
By: /s/ Craig R. Smith, M.D.
———————————————————————————————
Craig R. Smith, M.D.
Chairman of the Board, President
and Chief Executive Officer
Pursuant to the requirements of the Securities Act of 1933, this registration
statement has been signed by the following persons in the capacities and on the
date indicated.
We, the undersigned officers and directors of Guilford Pharmaceuticals Inc.,
hereby severally and individually constitute and appoint Craig R. Smith, M.D.,
Andrew R. Jordan, Thomas C. Seoh, and Michael J. Silver, and each of them, the
true and lawful attorneys and agents of each of us to execute in the name, place
and stead of each of us (individually and in any capacity stated below) any and
all amendments to this registration statement on Form S-8, and all instruments
necessary or advisable in connection therewith and to file the same with the
Securities and Exchange Commission, each of said attorneys and agents to have
power to act with or without the other and to have full power and authority to
do and perform in the name and on behalf of each of the undersigned every act
whatsoever necessary or advisable to be done in the premises as fully and to all
intents and purposes as any of the undersigned might or could do in person, and
we hereby ratify and confirm our signatures as they may be signed by our said
attorneys and agents and each of them to any and all such amendment and
amendments.
Date:  February 23, 2001
By:
/s/ Craig R. Smith, M.D.
————————————————
Craig R. Smith, M.D.
Chairman of the Board, President
and Chief Executive Officer
(Principal Executive Officer)
Date: February 23, 2001
By:
/s/ Andrew R. Jordan
————————————————
Andrew R. Jordan
Senior Vice President and
Chief Financial Officer
(Principal Accounting Officer)
Date: February 23, 2001
By:
/s/ George L. Bunting, Jr.
————————————————
George L. Bunting, Jr.
Director
Date: February 23, 2001
By:
/s/ Richard L. Casey
————————————————
Richard L. Casey
Director
Date: February 23, 2001
By:
/s/ Elizabeth M. Greetham
————————————————
Elizabeth M. Greetham
Director
Date: February 23, 2001
By:
/s/ Joseph Klein, III
————————————————
Joseph Klein, III
Director
Date: February 23, 2001
By:
/s/ Ronald M. Nordmann
————————————————
Ronald M. Nordmann
Director
Date: February 23, 2001
By:
/s/ Solomon H. Snyder, M.D.
————————————————
Solomon H. Snyder, M.D.
Director
Date: February 23, 2001
By:
/s/ W. Leigh Thompson, M.D., Ph.D.
————————————————
W. Leigh Thompson, M.D., Ph.D.
Director