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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<DIV style="font-family: 'Times New Roman',Times,serif">



<P align="right" style="font-size: 10pt"><B>As filed with the
Securities and Exchange Commission on June&nbsp;20, 2005<BR>
Registration No.&nbsp;333- </B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;



<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>






<P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>


<DIV align="left" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>





<P align="center" style="font-size: 18pt"><B>FORM S-8</B>

<DIV align="center" style="font-size: 10pt"><B>REGISTRATION STATEMENT</B></DIV>


<DIV align="center" style="font-size: 10pt"><B><I>Under</I></B></DIV>


<DIV align="center" style="font-size: 10pt"><B><I>The Securities Act of 1933</I></B></DIV>



<DIV align="left" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>


<P align="center" style="font-size: 24pt"><B>CYTOKINETICS, INCORPORATED</B>


<DIV align="center" style="font-size: 10pt"><FONT style="font-size:8pt"><B>(Exact name of Registrant as specified in its charter)</B></FONT></DIV>



<DIV align="left" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>
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<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top"><B>Delaware</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>94-3291317</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><FONT style="font-size:8pt"><B>(State or other jurisdiction of<BR>
incorporation or organization)</B></FONT>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><FONT style="font-size:8pt"><B>(I.R.S. Employer<BR>
Identification Number)</B></FONT></TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><B>280 East Grand Avenue<BR>
South San Francisco, CA 94080</B><BR>
<FONT style="font-size:8pt"><B>(Address of principal executive offices)</B></FONT>



<DIV align="left" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>



<P align="center" style="font-size: 10pt"><B>2004 EQUITY INCENTIVE PLAN</B><BR>
<FONT style="font-size:8pt"><B>(Full title of the plan)</B></FONT>



<DIV align="left" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>



<P align="center" style="font-size: 10pt"><B>James H. Sabry, M.D., Ph.D.<BR>
President and Chief Executive Officer<BR>
Cytokinetics, Incorporated<BR>
280 East Grand Avenue<BR>
South San Francisco, CA 94080<BR>
(650)&nbsp;624-3000</B><BR>
<FONT style="font-size:8pt"><B>(Name, address, and telephone number,
including area code, of agent for service)</B></FONT>



<DIV align="left" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>



<P align="center" style="font-size: 10pt"><I>Copy to:</I><BR>
<B>Michael J. O&#146;Donnell, Esq.<BR>
Martin J. Waters, Esq.<BR>
Gavin McCraley, Esq.<BR>
Wilson Sonsini Goodrich &#038; Rosati<BR>
Professional Corporation<BR>
650 Page Mill Road<BR>
Palo Alto, CA 94304-1050<BR>
(650)&nbsp;493-9300</B>



<DIV align="left" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>



<P align="center" style="font-size: 10pt">CALCULATION OF REGISTRATION FEE





<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="32%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="12%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="12%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="12%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="12%">&nbsp;</TD>
</TR>
<tr><td colspan="3" style="border-right: 1px solid #000000; border-top: 2px solid #000000">&nbsp;</td>
<td colspan="4" style="border-right: 1px solid #000000; border-top: 2px solid #000000">&nbsp;</td>
<td colspan="4" style="border-right: 1px solid #000000; border-top: 2px solid #000000">&nbsp;</td>
<td colspan="4" style="border-right: 1px solid #000000; border-top: 2px solid #000000">&nbsp;</td>
<td colspan="4" style="border-top: 2px solid #000000">&nbsp;</td>
</tr>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Proposed</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Proposed</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B></B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B></B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Amount</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Offering</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Aggregate</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Amount of</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Title of Securities</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>to be</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Price Per</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Offering</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Registration</B></TD>
</TR>

<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>to be Registered</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Registered (1)</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Share (2)</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Fee</B></TD>
</TR>
<tr><td colspan="3" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</td>
<td colspan="4" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</td>
<td colspan="4" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</td>
<td colspan="4" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</td>
<td colspan="4" style="border-top: 1px solid #000000">&nbsp;</td>
</tr>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">Common Stock
$0.001 par value</DIV></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">995,861 shares</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">$5.225</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">$5,203,373.73</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">$612.44</TD>
</TR>
<tr><td colspan="3" style="border-right: 1px solid #000000; border-bottom: 2px solid #000000">&nbsp;</td>
<td colspan="4" style="border-right: 1px solid #000000; border-bottom: 2px solid #000000">&nbsp;</td>
<td colspan="4" style="border-right: 1px solid #000000; border-bottom: 2px solid #000000">&nbsp;</td>
<td colspan="4" style="border-right: 1px solid #000000; border-bottom: 2px solid #000000">&nbsp;</td>
<td colspan="4" style="border-bottom: 2px solid #000000">&nbsp;</td>
</tr>
<!-- End Table Body -->
</TABLE>
</DIV>





<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Represents an additional 995,861 shares of Common Stock available for issuance under the Company&#146;s 2004 Equity Incentive Plan, as a result of provisions
in the Company&#146;s 2004 Equity Incentive Plan that allow automatic annual increases of Common Stock available for issuance under such plan.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Estimated in accordance with Rule 457(h) solely for the purpose of calculating the total registration fee. No options have been granted with respect to
such shares. The computation is based upon the average of the high and low prices of the Common Stock as reported on The Nasdaq Stock Market on June&nbsp;15,
2005.</TD>
</TR>

</TABLE>


<DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>







<P align="center" style="font-size: 10pt">&nbsp;
</DIV>



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<DIV style="font-family: 'Times New Roman',Times,serif">

<!-- TOC -->
<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

<P><CENTER>
<TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
<TR>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="76%"></TD>
</TR>
<TR><TD colspan="9"><A HREF="#000">PART II<BR> INFORMATION REQUIRED IN REGISTRATION STATEMENT</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Documents by Reference.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;8. Exhibits.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#004">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#005">POWER OF ATTORNEY</A></TD></TR>
<TR><TD colspan="9"><A HREF="#006">INDEX TO EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="f10107orexv5w1.htm">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="f10107orexv23w1.htm">EXHIBIT 23.1</A></TD></TR>
</TABLE>
</CENTER>
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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>







<P align="center" style="font-size: 10pt"><B>Statement Under General Instruction E<BR>
Registration of Additional Securities</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Unless as noted herein, the contents of the Cytokinetics, Incorporated&#146;s (the &#147;Company&#148;) Form
S-8 Registration Statement (File No.&nbsp;333-115146) are incorporated by reference into this
Registration Statement.



<P align="center" style="font-size: 10pt">1
</DIV>

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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<!-- link1 "PART II<BR> INFORMATION REQUIRED IN REGISTRATION STATEMENT" -->
<DIV align="left"><A NAME="000"></A></DIV>

<P align="center" style="font-size: 10pt"><B>PART II<BR>
INFORMATION REQUIRED IN REGISTRATION STATEMENT</B>


<!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference." -->
<DIV align="left"><A NAME="001"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;3. Incorporation of Documents by Reference.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;There are hereby incorporated by reference in this Registration Statement the following
documents and information heretofore filed by the Company with the Securities and Exchange
Commission:


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Annual Report filed on Form 10-K for the fiscal year ended December&nbsp;31, 2004.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Definitive Proxy Statement on Schedule&nbsp;14A, filed on April&nbsp;6,
2005.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Quarterly Report filed on Form 10-Q for the fiscal quarter
ended March&nbsp;31, 2005.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Current Reports on Form 8-K dated January&nbsp;6, 2005, February
7, 2005, March&nbsp;28, 2005, March&nbsp;30, 2005, and April&nbsp;5, 2005.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(5)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The description of the Company&#146;s common stock contained in the Company&#146;s
Registration Statement on Form 8-A filed pursuant to Section 12(g) of the
Exchange Act, as amended, and as declared effective on April&nbsp;29, 2004.</TD>
</TR>
</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the
Securities Exchange Act of 1934 on or after the date of this Registration Statement and prior to
the filing of a post-effective amendment which indicates that all securities offered have been sold
or which deregisters all securities then remaining unsold shall be deemed to be incorporated by
reference in this Registration Statement and to be part hereof from the date of filing of such
documents.

<!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel." -->
<DIV align="left"><A NAME="002"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Certain members of Wilson Sonsini Goodrich &#038; Rosati, Professional Corporation, and investment
partnerships of which such persons are partners, beneficially own 4,310 shares of the Company&#146;s
common stock.

<!-- link2 "Item&nbsp;8. Exhibits." -->
<DIV align="left"><A NAME="003"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;8. Exhibits.</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="10%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="88%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Number</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Description</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.1*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Common Stock Certificate.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.2*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Fourth Amended and Restated Investors Rights Agreement, dated March&nbsp;21,
2003, by and among the Company and certain stockholders of the
Company.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.3*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Loan and Security Agreement, dated September&nbsp;25, 1998, by and between the
Company and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.4*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amendment No.&nbsp;One to Loan and Security Agreement, dated February&nbsp;1, 1999.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.5*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;A preferred stock, dated
September&nbsp;25, 1998, issued by the Company to Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.6*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Loan and Security Agreement, dated December&nbsp;16, 1999, by and between the
Company and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.7*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amendment No.&nbsp;1 to Loan and Security Agreement, dated June&nbsp;29, 2000, by and
between the Company and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.8*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;B preferred stock, dated
December&nbsp;16, 1999, issued by the Company to Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.9*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Master Security Agreement, dated February&nbsp;2, 2001, by and between the
Company and General Electric Capital Corporation.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.10*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Cross-Collateral and Cross-Default Agreement by and between the Company
and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.11*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999,
issued by the Company to Bristow Investments, L.P.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.12*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999,
issued by the Company to the Laurence and Magdalena Shushan Family
Trust.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.13*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999,
issued by the Company to Slough Estates USA Inc.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.14*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;B preferred stock, dated
August&nbsp;30, 1999, issued by the Company to The Magnum Trust.</TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Wilson Sonsini Goodrich &#038; Rosati, Professional Corporation.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">10.3*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">2004 Equity Incentive Plan.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Wilson Sonsini Goodrich &#038; Rosati, Professional Corporation (see Exhibit&nbsp;5.1).</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (see page II-2).</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="3%" nowrap align="left">*</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Incorporated by reference to exhibits filed with the Company&#146;s Registration Statement on Form
S-1 (file no. 333-112261), and as declared effective on April&nbsp;29, 2004.</TD>
</TR>

</TABLE>



<P align="center" style="font-size: 10pt">II-1
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="004"></A></DIV>

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant, Cytokinetics,
Incorporated, a corporation organized and existing under the laws of the State of Delaware,
certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of South San Francisco, State of
California, on this 20<SUP style="font-size: 85%; vertical-align: text-top">th</SUP> day of June, 2005.


<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">CYTOKINETICS, INCORPORATED<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ James H. Sabry
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">James H. Sabry, M.D., Ph.D.&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">President and Chief Executive Officer
(Principal Executive Officer)&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>
<!-- link1 "POWER OF ATTORNEY" -->
<DIV align="left"><A NAME="005"></A></DIV>

<P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>




<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
and appoints James H. Sabry and Sharon Surrey-Barbari, jointly and severally, as his
attorneys-in-fact, with full power of substitution in each, for him in any and all capacities to
sign any amendments to this Registration Statement on Form S-8, and to file the same, with all
exhibits thereto and other documents in connection therewith, with the Securities and Exchange
Commission, hereby ratifying and confirming all that each of said attorneys-in-fact, or his
substitutes, may do or cause to be done by virtue hereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed below by the following persons in the capacities and on the dates indicated.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="40%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="25%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="25%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ James H. Sabry
<HR size="1" noshade color="#000000">
(James H. Sabry, M.D., Ph.D.)</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
President, Chief
Executive Officer and
Director (Principal
Executive Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;20, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Sharon Surrey-Barbari
<HR size="1" noshade color="#000000">
(Sharon Surrey-Barbari)</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Chief Financial
Officer (Principal
Financial and
Accounting Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;20, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Stephen Dow
<HR size="1" noshade color="#000000">
(Stephen Dow)</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;20, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ A. Grant Heidrich, III
<HR size="1" noshade color="#000000">
(A. Grant Heidrich, III)</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;20, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Charles Homcy
<HR size="1" noshade color="#000000">
(Charles Homcy, M.D.)</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;20, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Mark McDade
<HR size="1" noshade color="#000000">
(Mark McDade)</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;20, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Michael Schmertzler
<HR size="1" noshade color="#000000">
(Michael Schmertzler)</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;20, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ James Spudich
<HR size="1" noshade color="#000000">
(James Spudich, Ph.D.)</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;20, 2005</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt">II-2
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link1 "INDEX TO EXHIBITS" -->
<DIV align="left"><A NAME="006"></A></DIV>

<P align="center" style="font-size: 10pt"><B>INDEX TO EXHIBITS</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="10%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="88%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Number</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Description</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.1*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Common Stock Certificate.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.2*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Fourth Amended and Restated Investors Rights Agreement, dated March&nbsp;21,
2003, by and among the Company and certain stockholders of the
Company.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.3*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Loan and Security Agreement, dated September&nbsp;25, 1998, by and between the
Company and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.4*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amendment No.&nbsp;One to Loan and Security Agreement, dated February&nbsp;1, 1999.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.5*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;A preferred stock, dated
September&nbsp;25, 1998, issued by the Company to Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.6*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Loan and Security Agreement, dated December&nbsp;16, 1999, by and between the
Company and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.7*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amendment No.&nbsp;1 to Loan and Security Agreement, dated June&nbsp;29, 2000, by and
between the Company and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.8*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;B preferred stock, dated
December&nbsp;16, 1999, issued by the Company to Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.9*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Master Security Agreement, dated February&nbsp;2, 2001, by and between the
Company and General Electric Capital Corporation.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.10*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Cross-Collateral and Cross-Default Agreement by and between the Company
and Comdisco.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.11*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999,
issued by the Company to Bristow Investments, L.P.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.12*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999,
issued by the Company to the Laurence and Magdalena Shushan Family
Trust.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.13*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of common stock, dated July&nbsp;20, 1999,
issued by the Company to Slough Estates USA Inc.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">4.14*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Warrant for the purchase of shares of Series&nbsp;B preferred stock, dated
August&nbsp;30, 1999, issued by the Company to The Magnum Trust.</TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Wilson Sonsini Goodrich &#038; Rosati, Professional Corporation.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">10.3*
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">2004 Equity Incentive Plan.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Wilson Sonsini Goodrich &#038; Rosati, Professional Corporation (see Exhibit&nbsp;5.1).</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="center"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (see page II-2).</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="3%" nowrap align="left">*</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Incorporated by reference to exhibits filed with the Company&#146;s Registration Statement on Form
S-1 (file no. 333-112261), and as declared effective on April&nbsp;29, 2004.</TD>
</TR>

</TABLE>




<P align="center" style="font-size: 10pt">II-3
</DIV>


</BODY>
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sv8
Table of Contents
As filed with the
Securities and Exchange Commission on June 20, 2005
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
CYTOKINETICS, INCORPORATED
(Exact name of Registrant as specified in its charter)
Delaware
94-3291317
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification Number)
280 East Grand Avenue
South San Francisco, CA 94080
(Address of principal executive offices)
2004 EQUITY INCENTIVE PLAN
(Full title of the plan)
James H. Sabry, M.D., Ph.D.
President and Chief Executive Officer
Cytokinetics, Incorporated
280 East Grand Avenue
South San Francisco, CA 94080
(650) 624-3000
(Name, address, and telephone number,
including area code, of agent for service)
Copy to:
Michael J. O'Donnell, Esq.
Martin J. Waters, Esq.
Gavin McCraley, Esq.
Wilson Sonsini Goodrich & Rosati
Professional Corporation
650 Page Mill Road
Palo Alto, CA 94304-1050
(650) 493-9300
CALCULATION OF REGISTRATION FEE
Proposed
Proposed
Maximum
Maximum
Maximum
Amount
Offering
Aggregate
Amount of
Title of Securities
to be
Price Per
Offering
Registration
to be Registered
Registered (1)
Share (2)
Fee
Common Stock
$0.001 par value
995,861 shares
$5.225
$5,203,373.73
$612.44
(1)
Represents an additional 995,861 shares of Common Stock available for issuance under the Company's 2004 Equity Incentive Plan, as a result of provisions
in the Company's 2004 Equity Incentive Plan that allow automatic annual increases of Common Stock available for issuance under such plan.
(2)
Estimated in accordance with Rule 457(h) solely for the purpose of calculating the total registration fee. No options have been granted with respect to
such shares. The computation is based upon the average of the high and low prices of the Common Stock as reported on The Nasdaq Stock Market on June 15,
2005.
TABLE OF CONTENTS
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
Item 5. Interests of Named Experts and Counsel.
Item 8. Exhibits.
SIGNATURES
POWER OF ATTORNEY
INDEX TO EXHIBITS
EXHIBIT 5.1
EXHIBIT 23.1
Table of Contents
Statement Under General Instruction E
Registration of Additional Securities
Unless as noted herein, the contents of the Cytokinetics, Incorporated's (the "Company") Form
S-8 Registration Statement (File No. 333-115146) are incorporated by reference into this
Registration Statement.
1
Table of Contents
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
There are hereby incorporated by reference in this Registration Statement the following
documents and information heretofore filed by the Company with the Securities and Exchange
Commission:
(1)
The Company's Annual Report filed on Form 10-K for the fiscal year ended December 31, 2004.
(2)
The Company's Definitive Proxy Statement on Schedule 14A, filed on April 6,
2005.
(3)
The Company's Quarterly Report filed on Form 10-Q for the fiscal quarter
ended March 31, 2005.
(4)
The Company's Current Reports on Form 8-K dated January 6, 2005, February
7, 2005, March 28, 2005, March 30, 2005, and April 5, 2005.
(5)
The description of the Company's common stock contained in the Company's
Registration Statement on Form 8-A filed pursuant to Section 12(g) of the
Exchange Act, as amended, and as declared effective on April 29, 2004.
All documents filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the
Securities Exchange Act of 1934 on or after the date of this Registration Statement and prior to
the filing of a post-effective amendment which indicates that all securities offered have been sold
or which deregisters all securities then remaining unsold shall be deemed to be incorporated by
reference in this Registration Statement and to be part hereof from the date of filing of such
documents.
Item 5. Interests of Named Experts and Counsel.
Certain members of Wilson Sonsini Goodrich & Rosati, Professional Corporation, and investment
partnerships of which such persons are partners, beneficially own 4,310 shares of the Company's
common stock.
Item 8. Exhibits.
Exhibit
Number
Description
4.1*
Specimen Common Stock Certificate.
4.2*
Fourth Amended and Restated Investors Rights Agreement, dated March 21,
2003, by and among the Company and certain stockholders of the
Company.
4.3*
Loan and Security Agreement, dated September 25, 1998, by and between the
Company and Comdisco.
4.4*
Amendment No. One to Loan and Security Agreement, dated February 1, 1999.
4.5*
Warrant for the purchase of shares of Series A preferred stock, dated
September 25, 1998, issued by the Company to Comdisco.
4.6*
Loan and Security Agreement, dated December 16, 1999, by and between the
Company and Comdisco.
4.7*
Amendment No. 1 to Loan and Security Agreement, dated June 29, 2000, by and
between the Company and Comdisco.
4.8*
Warrant for the purchase of shares of Series B preferred stock, dated
December 16, 1999, issued by the Company to Comdisco.
4.9*
Master Security Agreement, dated February 2, 2001, by and between the
Company and General Electric Capital Corporation.
4.10*
Cross-Collateral and Cross-Default Agreement by and between the Company
and Comdisco.
4.11*
Warrant for the purchase of shares of common stock, dated July 20, 1999,
issued by the Company to Bristow Investments, L.P.
4.12*
Warrant for the purchase of shares of common stock, dated July 20, 1999,
issued by the Company to the Laurence and Magdalena Shushan Family
Trust.
4.13*
Warrant for the purchase of shares of common stock, dated July 20, 1999,
issued by the Company to Slough Estates USA Inc.
4.14*
Warrant for the purchase of shares of Series B preferred stock, dated
August 30, 1999, issued by the Company to The Magnum Trust.
5.1
Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation.
10.3*
2004 Equity Incentive Plan.
23.1
Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (see Exhibit 5.1).
24.1
Power of Attorney (see page II-2).
*
Incorporated by reference to exhibits filed with the Company's Registration Statement on Form
S-1 (file no. 333-112261), and as declared effective on April 29, 2004.
II-1
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant, Cytokinetics,
Incorporated, a corporation organized and existing under the laws of the State of Delaware,
certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of South San Francisco, State of
California, on this 20
th
day of June, 2005.
CYTOKINETICS, INCORPORATED
By:
/s/ James H. Sabry
James H. Sabry, M.D., Ph.D.
President and Chief Executive Officer
(Principal Executive Officer)
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
and appoints James H. Sabry and Sharon Surrey-Barbari, jointly and severally, as his
attorneys-in-fact, with full power of substitution in each, for him in any and all capacities to
sign any amendments to this Registration Statement on Form S-8, and to file the same, with all
exhibits thereto and other documents in connection therewith, with the Securities and Exchange
Commission, hereby ratifying and confirming all that each of said attorneys-in-fact, or his
substitutes, may do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed below by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ James H. Sabry
(James H. Sabry, M.D., Ph.D.)
President, Chief
Executive Officer and
Director (Principal
Executive Officer)
June 20, 2005
/s/ Sharon Surrey-Barbari
(Sharon Surrey-Barbari)
Chief Financial
Officer (Principal
Financial and
Accounting Officer)
June 20, 2005
/s/ Stephen Dow
(Stephen Dow)
Director
June 20, 2005
/s/ A. Grant Heidrich, III
(A. Grant Heidrich, III)
Director
June 20, 2005
/s/ Charles Homcy
(Charles Homcy, M.D.)
Director
June 20, 2005
/s/ Mark McDade
(Mark McDade)
Director
June 20, 2005
/s/ Michael Schmertzler
(Michael Schmertzler)
Director
June 20, 2005
/s/ James Spudich
(James Spudich, Ph.D.)
Director
June 20, 2005
II-2
Table of Contents
INDEX TO EXHIBITS
Exhibit
Number
Description
4.1*
Specimen Common Stock Certificate.
4.2*
Fourth Amended and Restated Investors Rights Agreement, dated March 21,
2003, by and among the Company and certain stockholders of the
Company.
4.3*
Loan and Security Agreement, dated September 25, 1998, by and between the
Company and Comdisco.
4.4*
Amendment No. One to Loan and Security Agreement, dated February 1, 1999.
4.5*
Warrant for the purchase of shares of Series A preferred stock, dated
September 25, 1998, issued by the Company to Comdisco.
4.6*
Loan and Security Agreement, dated December 16, 1999, by and between the
Company and Comdisco.
4.7*
Amendment No. 1 to Loan and Security Agreement, dated June 29, 2000, by and
between the Company and Comdisco.
4.8*
Warrant for the purchase of shares of Series B preferred stock, dated
December 16, 1999, issued by the Company to Comdisco.
4.9*
Master Security Agreement, dated February 2, 2001, by and between the
Company and General Electric Capital Corporation.
4.10*
Cross-Collateral and Cross-Default Agreement by and between the Company
and Comdisco.
4.11*
Warrant for the purchase of shares of common stock, dated July 20, 1999,
issued by the Company to Bristow Investments, L.P.
4.12*
Warrant for the purchase of shares of common stock, dated July 20, 1999,
issued by the Company to the Laurence and Magdalena Shushan Family
Trust.
4.13*
Warrant for the purchase of shares of common stock, dated July 20, 1999,
issued by the Company to Slough Estates USA Inc.
4.14*
Warrant for the purchase of shares of Series B preferred stock, dated
August 30, 1999, issued by the Company to The Magnum Trust.
5.1
Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation.
10.3*
2004 Equity Incentive Plan.
23.1
Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (see Exhibit 5.1).
24.1
Power of Attorney (see page II-2).
*
Incorporated by reference to exhibits filed with the Company's Registration Statement on Form
S-1 (file no. 333-112261), and as declared effective on April 29, 2004.
II-3