<HTML>
<HEAD>
<TITLE>sv8</TITLE>
</HEAD>
<BODY bgcolor="#FFFFFF">
<!-- PAGEBREAK -->
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<P align="center"><FONT size="2">As filed with the Securities and Exchange Commission on April&nbsp;1, 2003<BR>
Registration No.&nbsp;333-__________
</FONT>
<P align="center"><FONT size="2"><B>SECURITIES AND EXCHANGE COMMISSION<BR>
WASHINGTON, D.C. 20549</B>
</FONT>

<P align="center"><FONT size="5"><B>FORM S-8</B>
</FONT>

<P align="center"><FONT size="2"><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</B>
</FONT>

<P align="center"><FONT size="5"><B>HUMAN GENOME SCIENCES, INC.</B></FONT><BR>
<FONT size="2">(Exact name of registrant as specified in its charter)</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="75%">
<TR valign="bottom">
    <TD width="51%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="44%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2"><B>Delaware</B></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
<B>22-3178468</B></FONT></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2">(State or other jurisdiction of<BR>
incorporation or organization)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
(I.R.S. Employer Identification No.)</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2"><B>9410 Key West Avenue<BR>
Rockville, Maryland</B></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="bottom"><FONT size="2">
<B>20850-3338</B></FONT></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2">(Address of principal executive offices)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
(Zip Code)</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2"><B>HUMAN GENOME SCIENCES, INC. AMENDED AND RESTATED 2000 STOCK INCENTIVE PLAN</B><BR>
(Full title of plan)
</FONT>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="65%">
<TR valign="bottom">
    <TD width="50%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="45%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2">(Name, address and telephone<BR>
number of agent for service)<BR>
<B>William A. Haseltine, Ph.D.<BR>
Human Genome Sciences, Inc.<BR>
9410 Key West Avenue<BR>
Rockville, Maryland 20850-3338<BR>
(301)&nbsp;309-8504</B></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="bottom"><FONT size="2">
(Copy to:)<BR>
<B>R.W. Smith, Jr., Esquire<BR>
Piper Rudnick LLP<BR>
6225 Smith Avenue<BR>
Baltimore, Maryland 21209-3600<BR>
(410)&nbsp;580-3000</B></FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B>
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
    <TD width="43%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="6%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="6%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="6%">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD nowrap colspan="17" align="center"><HR size="4" noshade></TD>
</TR>
<TR valign="bottom">
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Maximum</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Maximum</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>to be</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Title of Securities to be Registered</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registered</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Price Per Unit</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Fee</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap colspan="17" align="center"><HR size="1" noshade></TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock, par value $0.01 per share (1)</FONT></DIV></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right"><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">6,442,527</FONT></TD>
    <TD nowrap><FONT size="2">(2)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">8.80</FONT></TD>
    <TD nowrap><FONT size="2">(3)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">56,694,238</FONT></TD>
    <TD nowrap><FONT size="2">(3)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">4,586.56</FONT></TD>
    <TD nowrap><FONT size="2">(3)</FONT></TD>
</TR>

<TR valign="bottom">
    <TD nowrap colspan="17" align="center"><HR size="4" noshade></TD>
</TR>

</TABLE>
</CENTER>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Includes rights (&#147;Rights&#148;) to purchase shares of the Registrant&#146;s junior
participating preferred stock, issuable pursuant to that certain Rights
Agreement between the Registrant and American Stock Transfer &#038; Trust
Company, as Rights Agent, dated as of May&nbsp;20, 1998. The value
attributable to the Rights, if any, is reflected in the market price of
the Common Stock.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">The shares of Common Stock of the Registrant (the &#147;Common Stock&#148;)
registered on this Registration Statement are in addition to shares of
Common Stock registered on Forms S-8 filed on August&nbsp;30, 2000 (file number
333-44798), August&nbsp;3, 2001 (file number 333-66670) and May&nbsp;30, 2002 (file
number 333-89392).</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Estimated solely for the purposes of calculating the registration fee
under Rule&nbsp;457(c) and (h). The proposed maximum offering price per share,
proposed maximum aggregate offering price and the amount of the
registration fee are based on the average of the daily high and low sale
prices of the Common Stock on the NASDAQ National Market system on March
26, 2003 (i.e., $8.80).</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">&nbsp;</FONT>
<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>


<P align="center"><FONT size="2">INCORPORATION BY REFERENCE
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to General Instruction E to Form&nbsp;S-8, the contents of the
Registration Statements filed on Forms S-8 by Human Genome Sciences, Inc. (the
&#147;Registrant&#148;) on August&nbsp;30, 2000 (file number 333-44798), August&nbsp;3, 2001 (file
number 333-66670) and May&nbsp;30, 2002 (file number 333-89392) with respect to
securities offered pursuant to the Human Genome Sciences, Inc. Amended and
Restated 2000 Stock Incentive Plan are incorporated by reference herein.
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Registrant pursuant to Sections&nbsp;13(a), 13(c),
14 or 15(d) of the Securities Exchange Act of 1934, as amended, subsequent to
the date of this Registration Statement and prior to the filing of a
post-effective amendment that indicates that all securities offered have been
sold or that deregisters all securities remaining unsold, shall be deemed to be
incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing of such documents.
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any statement contained in a document incorporated or deemed to be
incorporated by reference herein shall be deemed to be modified or superseded
for purposes of this Registration Statement to the extent that a statement
contained herein or in any other subsequently filed document which also is or
is deemed to be incorporated by reference herein modifies or supersedes such
statement. Any such statement so modified or superseded shall not be deemed,
except as so modified or superseded, to constitute a part of this Registration
Statement.
</FONT>

<!-- link2 "ITEM 8. EXHIBITS." -->
<DIV align="left"><A NAME="000"></A></DIV>

<P align="left"><FONT size="2">ITEM 8. &nbsp;EXHIBITS
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
    <TD width="6%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="89%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="LEFT"><FONT size="1"><B>EXHIBIT</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="LEFT"><FONT size="1"><B>NUMBER</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="left"><FONT size="1"><B>DESCRIPTION</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Certificate of Incorporation of the Registrant (filed as Exhibit&nbsp;3.1 of
the Registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended December
31, 1993, as amended by Exhibit&nbsp;3.3 to the Registrant&#146;s Annual Report on
Form&nbsp;10-K for the year ended December&nbsp;31, 1997, Exhibit&nbsp;3.1 to the
Registrant&#146;s Current Report on Form&nbsp;8-K filed on December&nbsp;16, 1999, and
Exhibit&nbsp;3.1 to the Registrant&#146;s Quarterly Report on Form&nbsp;10-Q for the
quarter ended June&nbsp;30, 2001, and incorporated herein by reference)</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
By-Laws of the Registrant (filed as Exhibit&nbsp;3.2 to the Registrant&#146;s
Quarterly Report on Form&nbsp;10-Q for the quarter ended June&nbsp;30, 2000, and
incorporated herein by reference)</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.3</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Rights Agreement between the Registrant and American Stock Transfer &amp;
Trust Company, as Rights Agent, dated as of May&nbsp;20, 1998 (filed as Exhibit
4 of the Registrant&#146;s Current Report on Form&nbsp;8-K filed on May&nbsp;28, 1998,
and incorporated herein by reference)</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.4</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive
Plan (filed as Exhibit&nbsp;A of the Registrant&#146;s Definitive Proxy Statement on
Schedule&nbsp;14A, filed April&nbsp;18, 2001, and incorporated herein by reference)</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">5.1*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion of Piper Rudnick LLP, counsel for the Registrant, regarding the
legal validity of the shares of Common Stock being registered under this
Registration Statement</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">23.1*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Piper Rudnick LLP, counsel for the Registrant (contained in
Exhibit&nbsp;5.1)</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">23.2*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, Independent Auditors</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">24.1*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Power of Attorney (included on Signature Page)</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P>
<HR size="1" width="18%" align="left" noshade>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">*</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Filed herewith.</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">&nbsp;</FONT>
<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<!-- link1 "SIGNATURES" -->
<P align="center"><FONT size="2"><B>SIGNATURES</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form&nbsp;S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Rockville, State of Maryland, on the 1st day of
April, 2003.
</FONT>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
    <TD width="50%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="47%"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="top">
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD colspan="2"><FONT size="2">HUMAN GENOME SCIENCES, INC.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="top">
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">By:</FONT></TD>
    <TD><FONT size="2">/s/ William A. Haseltine, Ph.D.
<HR noshade size="1" width="70%" align="left">
William A. Haseltine, Ph.D.<BR>
Chairman of the Board and<BR>
Chief Executive Officer</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">&nbsp;</FONT>
<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
<!-- link1 "POWERS OF ATTORNEY" -->
<P align="center"><FONT size="2"><B>POWERS OF ATTORNEY</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL MEN BY THESE PRESENTS, that the undersigned officers and
Directors of Human Genome Sciences, Inc., a Delaware corporation (the
&#147;Corporation&#148;), hereby constitute and appoint William A. Haseltine, Ph.D., and
Craig A. Rosen, Ph.D., and each of them, the true and lawful agents and
attorneys-in-fact of the undersigned with full power and authority in said
agents and attorneys-in-fact, and in either or both of them, to sign for the
undersigned and in their respective names as officers and as Directors of the
Corporation, a Registration Statement on Form&nbsp;S-8 (or other appropriate form)
(the &#147;Registration Statement&#148;) relating to the proposed issuance of Common
Stock, par value $0.01 per share, of the Corporation pursuant to the exercise
of stock options and other awards granted under the Human Genome Sciences, Inc.
Amended and Restated 2000 Stock Incentive Plan (or any and all amendments,
including post-effective amendments, to such Registration Statement) and file
the same, with all exhibits thereto and other documents in connection
therewith, with the Securities and Exchange Commission, and with full power of
substitution, hereby ratifying and confirming all that each of said
attorneys-in-fact, or his substitute or substitutes, may do or cause to be done
by virtue hereof.
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the date indicated.
</FONT>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="85%">
<TR valign="bottom">
    <TD width="35%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="46%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="13%">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ William A. Haseltine, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
William A. Haseltine, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Chairman of the Board and<BR>
Chief Executive Officer<BR>
(principal executive officer)
</FONT></TD>

    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">April 1, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Craig A. Rosen, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
Craig A. Rosen, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
President, Research<BR>
and Development and Director<BR>

</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">April 1, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Steven C. Mayer<BR>
</FONT><HR size="1" noshade><FONT size="2">
Steven C. Mayer</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Senior Vice President and<BR>
Chief Financial Officer<BR>
(principal financial and accounting officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">April 1, 2003</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Richard J. Danzig<BR>
</FONT><HR size="1" noshade><FONT size="2">
Richard J. Danzig</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">April 1, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ J&#252;rgen Drews, M.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
J&#252;rgen Drews, M.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">April 1, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Richard C. Holbrooke<BR>
</FONT><HR size="1" noshade><FONT size="2">
Richard C. Holbrooke</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">April 1, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Robert D. Hormats<BR>
</FONT><HR size="1" noshade><FONT size="2">
Robert D. Hormats</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">April 1, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Argeris N. Karabelas, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
Argeris (Jerry) N. Karabelas, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">March 24, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Max Link, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
Max Link, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top" nowrap><FONT size="2">April 1, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Alan G. Spoon<BR>
</FONT><HR size="1" noshade><FONT size="2">
Alan G. Spoon</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">March 27, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Laura D&#146;Andrea Tyson, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
Laura D&#146;Andrea Tyson, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">April 1, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ James B. Wyngaarden, M.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
James B. Wyngaarden, M.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">April 1, 2003</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>
<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<!-- link2 "EXHIBIT INDEX" -->
<P align="left"><FONT size="2"><B>EXHIBIT INDEX</B>
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="95%">
<TR valign="bottom">
    <TD width="6%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="89%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>EXHIBIT</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>NUMBER</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="left"><FONT size="1"><B>DESCRIPTION</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Certificate of Incorporation of the Registrant (filed as Exhibit&nbsp;3.1 of
the Registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended December
31, 1993, as amended by Exhibit&nbsp;3.3 to the Registrant&#146;s Annual Report on
Form&nbsp;10-K for the year ended December&nbsp;31, 1997, Exhibit&nbsp;3.1 to the
Registrant&#146;s Current Report on Form&nbsp;8-K filed on December&nbsp;16, 1999, and
Exhibit&nbsp;3.1 to the Registrant&#146;s Quarterly Report on Form&nbsp;10-Q for the
quarter ended June&nbsp;30, 2001, and incorporated herein by reference)</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
By-Laws of the Registrant (filed as Exhibit&nbsp;3.2 to the Registrant&#146;s
Quarterly Report on Form&nbsp;10-Q for the quarter ended June&nbsp;30, 2000, and
incorporated herein by reference)</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.3</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Rights Agreement between the Registrant and American Stock Transfer &amp;
Trust Company, as Rights Agent, dated as of May&nbsp;20, 1998 (filed as Exhibit
4 of the Registrant&#146;s Current Report on Form&nbsp;8-K filed on May&nbsp;28, 1998,
and incorporated herein by reference)</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.4</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive
Plan (filed as Exhibit&nbsp;A of the Registrant&#146;s Definitive Proxy Statement on
Schedule&nbsp;14A, filed April&nbsp;18, 2001, and incorporated herein by reference)</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">5.1*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion of Piper Rudnick LLP, counsel for the Registrant, regarding the
legal validity of the shares of Common Stock being registered under this
Registration Statement</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">23.1*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Piper Rudnick LLP, counsel for the Registrant (contained in
Exhibit&nbsp;5.1)</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">23.2*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, Independent Auditors</FONT></TD>
</TR>

<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">24.1*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Power of Attorney (included on Signature Page)</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P>
<HR size="1" width="18%" align="left" noshade>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">*</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Filed herewith.</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">&nbsp;</FONT>
</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "w84933sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 30863}]
{"company-data": {"conformed-name": "HUMAN GENOME SCIENCES INC", "cik": "0000901219", "assigned-sic": "2835", "irs-number": "223178468", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-104219", "film-number": "03634735"}, "business-address": {"street1": "9410 KEY W AVE", "city": "ROCKVILLE", "state": "MD", "zip": "20850-3338", "phone": "3013098504"}, "mail-address": {"street1": "9410 KEY WEST AVE", "city": "ROCKVILLE", "state": "MD", "zip": "20850"}}
sv8
As filed with the Securities and Exchange Commission on April 1, 2003
Registration No. 333-__________
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
HUMAN GENOME SCIENCES, INC.
(Exact name of registrant as specified in its charter)
Delaware
22-3178468
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer Identification No.)
9410 Key West Avenue
Rockville, Maryland
20850-3338
(Address of principal executive offices)
(Zip Code)
HUMAN GENOME SCIENCES, INC. AMENDED AND RESTATED 2000 STOCK INCENTIVE PLAN
(Full title of plan)
(Name, address and telephone
number of agent for service)
William A. Haseltine, Ph.D.
Human Genome Sciences, Inc.
9410 Key West Avenue
Rockville, Maryland 20850-3338
(301) 309-8504
(Copy to:)
R.W. Smith, Jr., Esquire
Piper Rudnick LLP
6225 Smith Avenue
Baltimore, Maryland 21209-3600
(410) 580-3000
CALCULATION OF REGISTRATION FEE
Proposed
Proposed
Amount
Maximum
Maximum
Amount of
to be
Offering
Aggregate
Registration
Title of Securities to be Registered
Registered
Price Per Unit
Offering Price
Fee
Common Stock, par value $0.01 per share (1)
6,442,527
(2)
$
8.80
(3)
$
56,694,238
(3)
$
4,586.56
(3)
(1)
Includes rights ("Rights") to purchase shares of the Registrant's junior
participating preferred stock, issuable pursuant to that certain Rights
Agreement between the Registrant and American Stock Transfer & Trust
Company, as Rights Agent, dated as of May 20, 1998. The value
attributable to the Rights, if any, is reflected in the market price of
the Common Stock.
(2)
The shares of Common Stock of the Registrant (the "Common Stock")
registered on this Registration Statement are in addition to shares of
Common Stock registered on Forms S-8 filed on August 30, 2000 (file number
333-44798), August 3, 2001 (file number 333-66670) and May 30, 2002 (file
number 333-89392).
(3)
Estimated solely for the purposes of calculating the registration fee
under Rule 457(c) and (h). The proposed maximum offering price per share,
proposed maximum aggregate offering price and the amount of the
registration fee are based on the average of the daily high and low sale
prices of the Common Stock on the NASDAQ National Market system on March
26, 2003 (i.e., $8.80).
INCORPORATION BY REFERENCE
Pursuant to General Instruction E to Form S-8, the contents of the
Registration Statements filed on Forms S-8 by Human Genome Sciences, Inc. (the
"Registrant") on August 30, 2000 (file number 333-44798), August 3, 2001 (file
number 333-66670) and May 30, 2002 (file number 333-89392) with respect to
securities offered pursuant to the Human Genome Sciences, Inc. Amended and
Restated 2000 Stock Incentive Plan are incorporated by reference herein.
All documents filed by the Registrant pursuant to Sections 13(a), 13(c),
14 or 15(d) of the Securities Exchange Act of 1934, as amended, subsequent to
the date of this Registration Statement and prior to the filing of a
post-effective amendment that indicates that all securities offered have been
sold or that deregisters all securities remaining unsold, shall be deemed to be
incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing of such documents.
Any statement contained in a document incorporated or deemed to be
incorporated by reference herein shall be deemed to be modified or superseded
for purposes of this Registration Statement to the extent that a statement
contained herein or in any other subsequently filed document which also is or
is deemed to be incorporated by reference herein modifies or supersedes such
statement. Any such statement so modified or superseded shall not be deemed,
except as so modified or superseded, to constitute a part of this Registration
Statement.
ITEM 8.  EXHIBITS
EXHIBIT
NUMBER
DESCRIPTION
4.1
Certificate of Incorporation of the Registrant (filed as Exhibit 3.1 of
the Registrant's Annual Report on Form 10-K for the year ended December
31, 1993, as amended by Exhibit 3.3 to the Registrant's Annual Report on
Form 10-K for the year ended December 31, 1997, Exhibit 3.1 to the
Registrant's Current Report on Form 8-K filed on December 16, 1999, and
Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q for the
quarter ended June 30, 2001, and incorporated herein by reference)
4.2
By-Laws of the Registrant (filed as Exhibit 3.2 to the Registrant's
Quarterly Report on Form 10-Q for the quarter ended June 30, 2000, and
incorporated herein by reference)
4.3
Rights Agreement between the Registrant and American Stock Transfer &
Trust Company, as Rights Agent, dated as of May 20, 1998 (filed as Exhibit
4 of the Registrant's Current Report on Form 8-K filed on May 28, 1998,
and incorporated herein by reference)
4.4
Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive
Plan (filed as Exhibit A of the Registrant's Definitive Proxy Statement on
Schedule 14A, filed April 18, 2001, and incorporated herein by reference)
5.1*
Opinion of Piper Rudnick LLP, counsel for the Registrant, regarding the
legal validity of the shares of Common Stock being registered under this
Registration Statement
23.1*
Consent of Piper Rudnick LLP, counsel for the Registrant (contained in
Exhibit 5.1)
23.2*
Consent of Ernst & Young LLP, Independent Auditors
24.1*
Power of Attorney (included on Signature Page)
*
Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Rockville, State of Maryland, on the 1st day of
April, 2003.
HUMAN GENOME SCIENCES, INC.
By:
/s/ William A. Haseltine, Ph.D.
William A. Haseltine, Ph.D.
Chairman of the Board and
Chief Executive Officer
POWERS OF ATTORNEY
KNOW ALL MEN BY THESE PRESENTS, that the undersigned officers and
Directors of Human Genome Sciences, Inc., a Delaware corporation (the
"Corporation"), hereby constitute and appoint William A. Haseltine, Ph.D., and
Craig A. Rosen, Ph.D., and each of them, the true and lawful agents and
attorneys-in-fact of the undersigned with full power and authority in said
agents and attorneys-in-fact, and in either or both of them, to sign for the
undersigned and in their respective names as officers and as Directors of the
Corporation, a Registration Statement on Form S-8 (or other appropriate form)
(the "Registration Statement") relating to the proposed issuance of Common
Stock, par value $0.01 per share, of the Corporation pursuant to the exercise
of stock options and other awards granted under the Human Genome Sciences, Inc.
Amended and Restated 2000 Stock Incentive Plan (or any and all amendments,
including post-effective amendments, to such Registration Statement) and file
the same, with all exhibits thereto and other documents in connection
therewith, with the Securities and Exchange Commission, and with full power of
substitution, hereby ratifying and confirming all that each of said
attorneys-in-fact, or his substitute or substitutes, may do or cause to be done
by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the date indicated.
Signature
Title
Date
/s/ William A. Haseltine, Ph.D.
William A. Haseltine, Ph.D.
Chairman of the Board and
Chief Executive Officer
(principal executive officer)
April 1, 2003
/s/ Craig A. Rosen, Ph.D.
Craig A. Rosen, Ph.D.
President, Research
and Development and Director
April 1, 2003
/s/ Steven C. Mayer
Steven C. Mayer
Senior Vice President and
Chief Financial Officer
(principal financial and accounting officer)
April 1, 2003
/s/ Richard J. Danzig
Richard J. Danzig
Director
April 1, 2003
/s/ Jürgen Drews, M.D.
Jürgen Drews, M.D.
Director
April 1, 2003
/s/ Richard C. Holbrooke
Richard C. Holbrooke
Director
April 1, 2003
/s/ Robert D. Hormats
Robert D. Hormats
Director
April 1, 2003
/s/ Argeris N. Karabelas, Ph.D.
Argeris (Jerry) N. Karabelas, Ph.D.
Director
March 24, 2003
/s/ Max Link, Ph.D.
Max Link, Ph.D.
Director
April 1, 2003
/s/ Alan G. Spoon
Alan G. Spoon
Director
March 27, 2003
/s/ Laura D'Andrea Tyson, Ph.D.
Laura D'Andrea Tyson, Ph.D.
Director
April 1, 2003
/s/ James B. Wyngaarden, M.D.
James B. Wyngaarden, M.D.
Director
April 1, 2003
EXHIBIT INDEX
EXHIBIT
NUMBER
DESCRIPTION
4.1
Certificate of Incorporation of the Registrant (filed as Exhibit 3.1 of
the Registrant's Annual Report on Form 10-K for the year ended December
31, 1993, as amended by Exhibit 3.3 to the Registrant's Annual Report on
Form 10-K for the year ended December 31, 1997, Exhibit 3.1 to the
Registrant's Current Report on Form 8-K filed on December 16, 1999, and
Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q for the
quarter ended June 30, 2001, and incorporated herein by reference)
4.2
By-Laws of the Registrant (filed as Exhibit 3.2 to the Registrant's
Quarterly Report on Form 10-Q for the quarter ended June 30, 2000, and
incorporated herein by reference)
4.3
Rights Agreement between the Registrant and American Stock Transfer &
Trust Company, as Rights Agent, dated as of May 20, 1998 (filed as Exhibit
4 of the Registrant's Current Report on Form 8-K filed on May 28, 1998,
and incorporated herein by reference)
4.4
Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive
Plan (filed as Exhibit A of the Registrant's Definitive Proxy Statement on
Schedule 14A, filed April 18, 2001, and incorporated herein by reference)
5.1*
Opinion of Piper Rudnick LLP, counsel for the Registrant, regarding the
legal validity of the shares of Common Stock being registered under this
Registration Statement
23.1*
Consent of Piper Rudnick LLP, counsel for the Registrant (contained in
Exhibit 5.1)
23.2*
Consent of Ernst & Young LLP, Independent Auditors
24.1*
Power of Attorney (included on Signature Page)
*
Filed herewith.