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<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">As filed with the Securities and Exchange Commission on
November 9, 2004
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Registration No.&nbsp;333-<u>&nbsp;&nbsp;&nbsp;</u></TD>
</TR>


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<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>


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<HR size="1" noshade color="#000000" style="margin-top: -10px">





<P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>


<P align="center" style="font-size: 10pt"><HR align="center" size="1" noshade width="25%">


<P align="center" style="font-size: 18pt"><B>FORM S-8</B>

<DIV align="center" style="font-size: 10pt"><B>REGISTRATION STATEMENT</B></DIV>


<DIV align="center" style="font-size: 10pt"><B>UNDER</B></DIV>


<DIV align="center" style="font-size: 10pt"><B>THE SECURITIES ACT OF 1933</B></DIV>


<P align="center" style="font-size: 24pt"><B>ONYX PHARMACEUTICALS, INC.</B>

<DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>



<P align="center" style="font-size: 10pt"><HR align="center" size="1" noshade width="25%">


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">

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    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>

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<TR valign="bottom">
    <TD align="center" valign="top"><B>Delaware</B><BR>
(State of incorporation)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>94-3154463</B><BR>
(I.R.S. Employer Identification No.)</TD>
</TR>


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</DIV>



<P align="center" style="font-size: 10pt"><HR align="center" size="1" noshade width="25%">



<P align="center" style="font-size: 10pt"><B>3031 Research Drive<BR>
Richmond, California 94806<BR>
(510)&nbsp;222-9700</B><BR>
(Address and telephone number of Principal Executive Offices)



<P align="center" style="font-size: 10pt"><B>1996 EQUITY INCENTIVE PLAN</B><BR>
(Full title of the plan)



<P align="center" style="font-size: 10pt"><B>Hollings C. Renton<BR>
Chairman of the Board, President and Chief Executive Officer<BR>
Onyx Pharmaceuticals, Inc.<BR>
3031 Research Drive<BR>
Richmond, California 94806<BR>
(510)&nbsp;222-9700</B><BR>
(Name, address, and telephone number of agent for service)



<P align="center" style="font-size: 10pt"><HR align="center" size="1" noshade width="25%">



<P align="center" style="font-size: 10pt">Copies to:<BR>
<B>Robert L. Jones, Esq.<BR>
Laura A. Berezin, Esq.<BR>
Cooley Godward LLP<BR>
Five Palo Alto Square<BR>
3000 El Camino Real<BR>
Palo Alto, California 94306-2155<BR>
(650)&nbsp;843-5000</B>



<P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">

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    <TD width="48%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="4%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="4%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Proposed Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Proposed Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Title Of Securities</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Amount To Be</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Offering Price Per</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Aggregate Offering</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Amount Of</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>To Be Registered</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Registered(1)</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Share(2)</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Price(2)</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Registration Fee</B><HR size="1" noshade></TD>
</TR>


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<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px">Stock options and Common Stock (par</DIV></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px">value $0.001)</DIV></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">600,000</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">27.58</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">16,548,000</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">2,097</TD>
    <TD>&nbsp;</TD>
</TR>


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</TABLE>
</DIV>



<P>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>This registration statement shall cover any additional shares of Common Stock which become issuable under the plan set forth
herein by reason of any stock dividend, stock split, recapitalization or any other similar transaction without receipt of
consideration which results in an increase in the number of shares of the registrant&#146;s outstanding Common Stock.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h) of the Securities
Act of 1933, as amended. The offering price per share and aggregate offering price are based on the average of the high and
low prices of the Registrant&#146;s Common Stock as reported on the Nasdaq National Market on November 2, 2004, for shares
reserved for future issuance pursuant to the plan set forth herein.</TD>
</TR>

</TABLE>


<P>
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<HR size="4" noshade color="#000000" style="margin-top: -10px">






<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<P align="center" style="font-size: 10pt"><B>PART II</B>



<P align="center" style="font-size: 10pt"><B>EXPLANATORY NOTE</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement on Form S-8 is being filed for the purpose of
registering an additional 600,000 shares of Onyx Pharmaceuticals, Inc.&#146;s (the
&#147;Company&#148;) Common Stock to be issued pursuant to the Company&#146;s 1996 Equity
Incentive Plan, as amended.


<P align="center" style="font-size: 10pt"><B>INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by Onyx Pharmaceuticals, Inc. with the
Securities and Exchange Commission are incorporated by reference into this
Registration Statement:


<P>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">a)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Registration Statement on Form S-8 filed on May&nbsp;30,
1996, under the Securities Act of 1933, as amended (file No.
333-04839);</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">b)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Registration Statement on Form S-8 filed on August&nbsp;29,
1997, under the Securities Act of 1933, as amended (file No.
333-34681);</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">c)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Registration Statement on Form S-8 filed on August&nbsp;6,
1998, under the Securities Act of 1933, as amended (file No.
333-60805);</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">d)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Registration Statement on Form S-8 filed on July&nbsp;30,
1999, under the Securities Act of 1933, as amended (file No.
333-84113);</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">e)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Registration Statement on Form S-8 filed on October&nbsp;18,
2000, under the Securities Act of 1933, as amended (file No.
333-48146);</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">f)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Registration Statement on Form S-8 filed on July&nbsp;6,
2001, under the Securities Act of 1933, as amended (file No.
333-64706);</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">g)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Registration Statement on Form S-8 filed on July&nbsp;22,
2002, under the Securities Act of 1933, as amended (file No.
333-96895); and</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="right">h)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Registration Statement on Form S-8 filed on November&nbsp;13,
2003, under the Securities Act of 1933, as amended (file No.
333-110469).</TD>
</TR>

</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents subsequently filed by the Company pursuant
to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing
of a post-effective amendment which indicates that all securities offered have
been sold or which deregisters all securities then remaining unsold, shall be
deemed to be incorporated by reference herein and to be a part of this
registration statement from the date of the filing of such reports and
documents.


<P align="center" style="font-size: 10pt">II-1
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<P align="center" style="font-size: 10pt"><B>EXHIBITS</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">

<!-- Begin Table Head --><TR valign="bottom">
    <TD width="8%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="87%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Number</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>


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<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1(1)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Restated Certificate of Incorporation. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2(2)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Certificate of Amendment to Amended and Restated Certificate of Incorporation. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3(1)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Bylaws of the Company. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4(1)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Stock Certificate. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Cooley Godward LLP. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, Independent Registered Public Accounting Firm. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Cooley Godward LLP. Reference is made to Exhibit&nbsp;5.1. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney. Reference is made to the signature pages. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">1996 Equity Incentive Plan, as amended.</TD>
</TR>


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</TABLE>
</DIV>




<P>

<HR size="1" width="18%" align="left" noshade>


<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="1%" nowrap align="right">(1)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Previously filed as an exhibit to Onyx&#146;s Registration Statement on Form&nbsp;SB-2 (No.
333-3176-LA), incorporated herein by reference.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="1%" nowrap align="right">(2)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Previously filed as an exhibit to Onyx&#146;s Quarterly Report on Form 10-Q for the Quarter ended
June&nbsp;30, 2000.</TD>
</TR>

</TABLE>



<P align="center" style="font-size: 10pt">II-2
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Richmond, State of California, on the 8th day
of November, 2004.


<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top">&nbsp;</TD>
    <TD colspan="3"><B>ONYX PHARMACEUTICALS, INC.</B><BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000">/s/ Hollings C. Renton
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2"><B>Hollings C. Renton</B>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2">Chairman of the Board, President <BR>
and Chief Executive Officer&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>

<P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>




<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Hollings C. Renton and Marilyn E.
Wortzman, and each or any one of them, his or her true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution,
for him or her and in his or her name, place and stead, in any and all
capacities, to sign any and all amendments (including post-effective
amendments) to this Registration Statement, and to file the same, with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and
agents, and each of them, full power and authority to do and perform each and
every act and thing requisite and necessary to be done in connection therewith,
as fully to all intents and purposes as he might or could do in person, hereby
ratifying and confirming all that said attorneys-in-fact and agents, or any of
them, or their or his or her substitutes or substitute, may lawfully do or
cause to be done by virtue hereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">

<!-- Begin Table Head --><TR valign="bottom">
    <TD width="34%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="45%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Signature</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Title</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Date</B><HR size="1" noshade></TD>
</TR>


<!-- End Table Head -->

<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top">/s/ Hollings C. Renton<BR>
<HR size="1" noshade>
Hollings C. Renton</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Chairman of the Board, President and Chief<BR>
Executive Officer <I>(Principal Executive and<BR>
Financial Officer)</I>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">November 8, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Marilyn E. Wortzman<BR>
<HR size="1" noshade>
Marilyn E. Wortzman</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Vice President, Finance and Administration<BR>
<I>(Principal Accounting Officer)</I>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">November 8, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Paul Goddard, Ph.D.<BR>
<HR size="1" noshade>
Paul Goddard, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">November 8, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Antonio Grillo-L&#243;pez, M.D.<BR>
<HR size="1" noshade>
Antonio Grillo-L&#243;pez, M.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">November 8, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Magnus Lundberg<BR>
<HR size="1" noshade>
Magnus Lundberg</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">November 8, 2004</TD>
</TR>


<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">II-3
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">

<!-- Begin Table Head --><TR valign="bottom">
    <TD width="34%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="45%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>Signature</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Title</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Date</B><HR size="1" noshade></TD>
</TR>


<!-- End Table Head -->

<!-- Begin Table Body -->
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ George A. Scangos, Ph.D.<BR>
<HR size="1" noshade>
George A. Scangos, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">November 8, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Nicole Vitullo<BR>
<HR size="1" noshade>
Nicole Vitullo</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">November 8, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" valign="top">/s/ Wendell Wierenga, Ph.D.<BR>
<HR size="1" noshade>
Wendell Wierenga, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">November 8, 2004</TD>
</TR>


<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">II-4
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<P align="center" style="font-size: 10pt"><B>EXHIBIT INDEX</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">

<!-- Begin Table Head --><TR valign="bottom">
    <TD width="8%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="87%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Exhibit No.</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Description</B><HR size="1" noshade></TD>
</TR>


<!-- End Table Head -->

<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1(1)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Restated Certificate of Incorporation. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2(2)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Certificate of Amendment to Amended and Restated Certificate of Incorporation. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3(1)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Bylaws of the Company. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4(1)
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Stock Certificate. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Cooley Godward LLP. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP, Independent Registered Public Accounting Firm. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Cooley Godward LLP. Reference is made to Exhibit&nbsp;5.1. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney. Reference is made to the signature pages. <BR><BR></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">1996 Equity Incentive Plan, as amended.</TD>
</TR>


<!-- End Table Body -->
</TABLE>
</DIV>




<P>

<HR size="1" width="18%" align="left" noshade>


<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="1%" nowrap align="right">(1)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Previously filed as an exhibit to Onyx&#146;s Registration Statement on Form&nbsp;SB-2 (No.
333-3176-LA), incorporated herein by reference.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="1%" nowrap align="right">(2)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Previously filed as an exhibit to Onyx&#146;s Quarterly Report on Form 10-Q for the Quarter ended
June&nbsp;30, 2000.</TD>
</TR>

</TABLE>




<P align="center" style="font-size: 10pt">&nbsp;
</DIV>


</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "f02921sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 27800}]
{"company-data": {"conformed-name": "ONYX PHARMACEUTICALS INC", "cik": "0001012140", "assigned-sic": "2836", "irs-number": "943154463", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-120324", "film-number": "041129906"}, "business-address": {"street1": "3031 RESEARCH DR", "street2": "BLDG A", "city": "RICHMOND", "state": "CA", "zip": "94806", "phone": "5102229700"}, "mail-address": {"street1": "3031 RESEARCH DRIVE", "city": "RICHMOND", "state": "CA", "zip": "94806"}}
sv8
As filed with the Securities and Exchange Commission on
November 9, 2004
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
ONYX PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)
Delaware
(State of incorporation)
94-3154463
(I.R.S. Employer Identification No.)
3031 Research Drive
Richmond, California 94806
(510) 222-9700
(Address and telephone number of Principal Executive Offices)
1996 EQUITY INCENTIVE PLAN
(Full title of the plan)
Hollings C. Renton
Chairman of the Board, President and Chief Executive Officer
Onyx Pharmaceuticals, Inc.
3031 Research Drive
Richmond, California 94806
(510) 222-9700
(Name, address, and telephone number of agent for service)
Copies to:
Robert L. Jones, Esq.
Laura A. Berezin, Esq.
Cooley Godward LLP
Five Palo Alto Square
3000 El Camino Real
Palo Alto, California 94306-2155
(650) 843-5000
CALCULATION OF REGISTRATION FEE
Proposed Maximum
Proposed Maximum
Title Of Securities
Amount To Be
Offering Price Per
Aggregate Offering
Amount Of
To Be Registered
Registered(1)
Share(2)
Price(2)
Registration Fee
Stock options and Common Stock (par
value $0.001)
600,000
$
27.58
$
16,548,000
$
2,097
(1)
This registration statement shall cover any additional shares of Common Stock which become issuable under the plan set forth
herein by reason of any stock dividend, stock split, recapitalization or any other similar transaction without receipt of
consideration which results in an increase in the number of shares of the registrant's outstanding Common Stock.
(2)
Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h) of the Securities
Act of 1933, as amended. The offering price per share and aggregate offering price are based on the average of the high and
low prices of the Registrant's Common Stock as reported on the Nasdaq National Market on November 2, 2004, for shares
reserved for future issuance pursuant to the plan set forth herein.
PART II
EXPLANATORY NOTE
This Registration Statement on Form S-8 is being filed for the purpose of
registering an additional 600,000 shares of Onyx Pharmaceuticals, Inc.'s (the
"Company") Common Stock to be issued pursuant to the Company's 1996 Equity
Incentive Plan, as amended.
INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
The following documents filed by Onyx Pharmaceuticals, Inc. with the
Securities and Exchange Commission are incorporated by reference into this
Registration Statement:
a)
The Company's Registration Statement on Form S-8 filed on May 30,
1996, under the Securities Act of 1933, as amended (file No.
333-04839);
b)
The Company's Registration Statement on Form S-8 filed on August 29,
1997, under the Securities Act of 1933, as amended (file No.
333-34681);
c)
The Company's Registration Statement on Form S-8 filed on August 6,
1998, under the Securities Act of 1933, as amended (file No.
333-60805);
d)
The Company's Registration Statement on Form S-8 filed on July 30,
1999, under the Securities Act of 1933, as amended (file No.
333-84113);
e)
The Company's Registration Statement on Form S-8 filed on October 18,
2000, under the Securities Act of 1933, as amended (file No.
333-48146);
f)
The Company's Registration Statement on Form S-8 filed on July 6,
2001, under the Securities Act of 1933, as amended (file No.
333-64706);
g)
The Company's Registration Statement on Form S-8 filed on July 22,
2002, under the Securities Act of 1933, as amended (file No.
333-96895); and
h)
The Company's Registration Statement on Form S-8 filed on November 13,
2003, under the Securities Act of 1933, as amended (file No.
333-110469).
All reports and other documents subsequently filed by the Company pursuant
to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing
of a post-effective amendment which indicates that all securities offered have
been sold or which deregisters all securities then remaining unsold, shall be
deemed to be incorporated by reference herein and to be a part of this
registration statement from the date of the filing of such reports and
documents.
II-1
EXHIBITS
Exhibit
Number
4.1(1)
Restated Certificate of Incorporation.
4.2(2)
Certificate of Amendment to Amended and Restated Certificate of Incorporation.
4.3(1)
Bylaws of the Company.
4.4(1)
Specimen Stock Certificate.
5.1
Opinion of Cooley Godward LLP.
23.1
Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Cooley Godward LLP. Reference is made to Exhibit 5.1.
24.1
Power of Attorney. Reference is made to the signature pages.
99.1
1996 Equity Incentive Plan, as amended.
(1)
Previously filed as an exhibit to Onyx's Registration Statement on Form SB-2 (No.
333-3176-LA), incorporated herein by reference.
(2)
Previously filed as an exhibit to Onyx's Quarterly Report on Form 10-Q for the Quarter ended
June 30, 2000.
II-2
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Richmond, State of California, on the 8th day
of November, 2004.
ONYX PHARMACEUTICALS, INC.
By:
/s/ Hollings C. Renton
Hollings C. Renton
Chairman of the Board, President
and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Hollings C. Renton and Marilyn E.
Wortzman, and each or any one of them, his or her true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution,
for him or her and in his or her name, place and stead, in any and all
capacities, to sign any and all amendments (including post-effective
amendments) to this Registration Statement, and to file the same, with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and
agents, and each of them, full power and authority to do and perform each and
every act and thing requisite and necessary to be done in connection therewith,
as fully to all intents and purposes as he might or could do in person, hereby
ratifying and confirming all that said attorneys-in-fact and agents, or any of
them, or their or his or her substitutes or substitute, may lawfully do or
cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
Signature
Title
Date
/s/ Hollings C. Renton
Hollings C. Renton
Chairman of the Board, President and Chief
Executive Officer
(Principal Executive and
Financial Officer)
November 8, 2004
/s/ Marilyn E. Wortzman
Marilyn E. Wortzman
Vice President, Finance and Administration
(Principal Accounting Officer)
November 8, 2004
/s/ Paul Goddard, Ph.D.
Paul Goddard, Ph.D.
Director
November 8, 2004
/s/ Antonio Grillo-López, M.D.
Antonio Grillo-López, M.D.
Director
November 8, 2004
/s/ Magnus Lundberg
Magnus Lundberg
Director
November 8, 2004
II-3
Signature
Title
Date
/s/ George A. Scangos, Ph.D.
George A. Scangos, Ph.D.
Director
November 8, 2004
/s/ Nicole Vitullo
Nicole Vitullo
Director
November 8, 2004
/s/ Wendell Wierenga, Ph.D.
Wendell Wierenga, Ph.D.
Director
November 8, 2004
II-4
EXHIBIT INDEX
Exhibit No.
Description
4.1(1)
Restated Certificate of Incorporation.
4.2(2)
Certificate of Amendment to Amended and Restated Certificate of Incorporation.
4.3(1)
Bylaws of the Company.
4.4(1)
Specimen Stock Certificate.
5.1
Opinion of Cooley Godward LLP.
23.1
Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Cooley Godward LLP. Reference is made to Exhibit 5.1.
24.1
Power of Attorney. Reference is made to the signature pages.
99.1
1996 Equity Incentive Plan, as amended.
(1)
Previously filed as an exhibit to Onyx's Registration Statement on Form SB-2 (No.
333-3176-LA), incorporated herein by reference.
(2)
Previously filed as an exhibit to Onyx's Quarterly Report on Form 10-Q for the Quarter ended
June 30, 2000.