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    <TD align="center" valign="top"><DIV style="margin-left:0px; text-indent:-0px">As filed with the Securities and Exchange Commission on June&nbsp;23, 2005
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Registration No.&nbsp;333-</TD>
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<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>






<P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>


<P align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>


<P align="center" style="font-size: 18pt"><B>FORM S-8</B>

<DIV align="center" style="font-size: 10pt"><B>REGISTRATION STATEMENT</B></DIV>


<DIV align="center" style="font-size: 10pt"><B>AND</B></DIV>


<DIV align="center" style="font-size: 10pt"><B>POST-EFFECTIVE AMENDMENT NO. 1 TO</B></DIV>


<DIV align="center" style="font-size: 10pt"><B>REGISTRATION STATEMENTS</B></DIV>


<DIV align="center" style="font-size: 10pt"><B>NO. 333-04839, NO. 333-34681, NO. 333-60805, NO. 333-84113, 333-48146, NO. 333-64706, 333-96895, 333-110469, AND 333-120324</B></DIV>


<DIV align="center" style="font-size: 10pt"><B>UNDER</B></DIV>


<DIV align="center" style="font-size: 10pt"><B>THE SECURITIES ACT OF 1933</B></DIV>



<P align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>


<P align="center" style="font-size: 24pt"><B>ONYX PHARMACEUTICALS, INC.</B>



<P align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)


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    <TD align="center" valign="top"><B>Delaware</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>94-3154463</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">(State of Incorporation)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
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<P align="center" style="font-size: 10pt"><B>2100 Powell Street<BR>
Emeryville, California 94608</B>



<P align="center" style="font-size: 10pt">(Address of principal executive offices)



<P align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>



<P align="center" style="font-size: 10pt"><FONT style="font-variant: SMALL-CAPS"><B>2005&nbsp;&nbsp;</B></FONT><B>EQUITY INCENTIVE PLAN<BR>
1996&nbsp; EQUITY INCENTIVE PLAN<BR>
1996&nbsp; NON-EMPLOYEE DIRECTORS&#146; STOCK OPTION PLAN</B><BR>
(Full title of the plans)



<P align="center" style="font-size: 10pt"><B>Hollings C. Renton<BR>
Chairman of the Board, President and Chief Executive Officer<BR>
Onyx Pharmaceuticals, Inc.<BR>
2100 Powell Street<BR>
Emeryville, California 94608<BR>
(510)&nbsp;597-6500</B>



<P align="center" style="font-size: 10pt">(Name, address, including zip code, and telephone number, including area code, of agent for service)



<P align="center" style="font-size: 10pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV>



<P align="center" style="font-size: 10pt">Copies to:<BR>
<B>Robert L. Jones, Esq.<BR>
Laura A. Berezin, Esq.<BR>
Cooley Godward LLP<BR>
Five Palo Alto Square<BR>
3000 El Camino Real<BR>
Palo Alto, California 94306-2155<BR>
(650)&nbsp;843-5000</B>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
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<P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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    <TD width="1%" style="border-bottom: 3px double #000000">&nbsp;</TD>
    <TD nowrap align="left" colspan="21" style="border-bottom: 3px double #000000; border-right: 0px solid #000000">&nbsp;</TD>
    <TD width="1%" style="border-right: 0px solid #000000; border-bottom: 3px double #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD width="1%" style="border-left: 3px double #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Proposed Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Proposed Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD width="1%" style="border-right: 3px double #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD width="1%" style="border-left: 3px double #000000">&nbsp;</TD>
    <TD nowrap align="center"><B>Title of Securities</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Amount to be</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Offering</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Aggregate</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Amount of</B></TD>
    <TD>&nbsp;</TD>
    <TD width="1%" style="border-right: 3px double #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD width="1%" style="border-left: 3px double #000000">&nbsp;</TD>
    <TD nowrap align="center"><B>to be Registered</B></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Registered</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Price per Share</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Offering Price</B></TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Registration Fee</B></TD>
    <TD>&nbsp;</TD>
    <TD width="1%" style="border-right: 3px double #000000">&nbsp;</TD>
</TR>

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<TR style="font-size: 1px">
    <TD width="1%" style="border-left: 3px double #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="1" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD width="1%" style="border-right: 3px double #000000; border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD width="1%" style="border-left: 3px double #000000">&nbsp;</TD>
    <TD><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par value
$0.001 per share</DIV></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD width="1%" style="border-right: 3px double #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 1px">
    <TD width="1%" style="border-left: 3px double #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="1" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD width="1%" style="border-right: 3px double #000000; border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD width="1%" style="border-left: 3px double #000000">&nbsp;</TD>
    <TD><DIV style="margin-left:45px; text-indent:-15px">Shares not
previously
registered</DIV></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
    <TD align="right">3,990,000 </TD>
    <TD nowrap>(1)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
    <TD align="right">$26.39</TD>
    <TD nowrap>(2)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
    <TD align="right">$105,296,100</TD>
    <TD nowrap>(2)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
    <TD align="right">$12,394</TD>
    <TD nowrap>(2)</TD>
    <TD width="1%" style="border-right: 3px double #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 1px">
    <TD width="1%" style="border-left: 3px double #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="1" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-right: 1px solid #000000; border-top: 1px solid #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
    <TD width="1%" style="border-right: 3px double #000000; border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD width="1%" style="border-left: 3px double #000000">&nbsp;</TD>
    <TD><DIV style="margin-left:45px; text-indent:-15px">Shares previously
registered</DIV></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
    <TD align="right">3,570,045 </TD>
    <TD nowrap>(1)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
    <TD align="right">N/A</TD>
    <TD nowrap>(3)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
    <TD align="right">N/A</TD>
    <TD nowrap>(3)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left">&nbsp;</TD>
    <TD align="right">N/A</TD>
    <TD nowrap>(3)</TD>
    <TD width="1%" style="border-right: 3px double #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 1px">
    <TD width="1%" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD colspan="1" align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD colspan="3" align="left" style="border-top: 3px double #000000">&nbsp;</TD>
    <TD width="1%" style="border-top: 3px double #000000">&nbsp;</TD>
</TR>
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</DIV>
<P align="left" style="font-size: 10pt">This registration statement is (a)&nbsp;a new registration statement; (b)&nbsp;a Post-Effective Amendment No.
1 to the registrant&#146;s registration statement on Form S-8 (File No.&nbsp;333-04839), as filed with the
Securities and Exchange Commission on May&nbsp;30, 1996 (the &#147;1996 Registration Statement&#148;); (c)&nbsp;a
Post-Effective Amendment No.&nbsp;1 to the registrant&#146;s registration statement on Form S-8 (File No.
333-34681), as filed with the Securities and Exchange Commission on August&nbsp;29, 1997 (the &#147;1997
Registration Statement&#148;); (d)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the registrant&#146;s registration
statement on Form S-8 (File No.&nbsp;333-60805), as filed with the Securities and Exchange Commission on
August&nbsp;6, 1998 (the &#147;1998 Registration Statement&#148;); (e)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the
registrant&#146;s registration statement on Form S-8 (File No.&nbsp;333-84113), as filed with the Securities
and Exchange Commission on July&nbsp;30, 1999 (the &#147;1999 Registration Statement&#148;); (f)&nbsp;a Post-Effective
Amendment No.&nbsp;1 to the registrant&#146;s registration statement on Form S-8 (File No.&nbsp;333-48146), as
filed with the Securities and Exchange Commission on October&nbsp;18, 2000 (the &#147;2000 Registration
Statement&#148;); (g)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the registrant&#146;s registration statement on
Form S-8 (File No.&nbsp;333-64706), as filed with the Securities and Exchange Commission on July&nbsp;6, 2001
(the &#147;2001 Registration Statement&#148;); (h)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the registrant&#146;s
registration statement on Form S-8 (File No.&nbsp;333-96895), as filed with the Securities and Exchange
Commission on July&nbsp;22, 2002 (the &#147;2002 Registration Statement&#148;); (i)&nbsp;a Post-Effective Amendment
No.&nbsp;1 to the registrant&#146;s registration statement on Form S-8 (File No.&nbsp;333-110469), as filed with
the Securities and Exchange Commission on November&nbsp;13, 2003 (the &#147;2003 Registration Statement&#148;);
and (j)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the registrant&#146;s registration statement on Form S-8
(File No.&nbsp;333-120324), as filed with the Securities and Exchange Commission on November&nbsp;9, 2004
(the &#147;2004 Registration Statement&#148;) (the 1996 Registration Statement, the 1997 Registration
Statement, the 1998 Registration Statement, the 1999 Registration Statement, the 2000 Registration
Statement, the 2001 Registration Statement, the 2002 Registration Statement, the 2003 Registration
Statement, and the 2004 Registration Statement are collectively referred herein as the &#147;Prior
Registration Statements&#148;). Pursuant to the Prior Registration Statements, shares of common stock,
par value $0.001, were registered for issuance under the Onyx Pharmaceuticals, Inc. 1996 Equity
Incentive Plan, as amended, and the Onyx Pharmaceuticals, Inc. 1996
Non-Employee Directors&#146; Stock Option Plan, as amended (collectively, the &#147;Prior Plans&#148;).


<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>


<P align="left" style="font-size: 10pt">(1)&nbsp;This Registration Statement covers 3,990,000 shares, not previously registered, under the Onyx
Pharmaceuticals, Inc. 2005 Equity Incentive Plan (the &#147;2005 Plan&#148;), which is the successor plan to
the Prior Plans. In addition, this Registration Statement covers up to 3,570,045 shares which were
previously registered under the Prior Registration Statements for offer or sale under the Prior
Plans and which may be offered or sold under the 2005 Plan (the &#147;Carried Forward Shares&#148;). The
Carried Forward Shares consist of shares remaining available for issuance under the
Prior Plans and shares subject to currently outstanding options under the Prior
Plans. In the event any of these shares subject to outstanding options are not issued under the
Prior Plans, such as when an option granted under any Prior Plan is canceled without being
exercised, such shares will become available for issuance under the 2005 Plan. Pursuant to Rule
416(a) of the Securities Act of 1933, as amended (the &#147;Securities Act&#148;), this Registration
Statement shall also cover any additional shares of Registrant&#146;s Common Stock that become issuable
under the 2005 Plan and the Prior Plans by reason of any stock dividend, stock split,
recapitalization or other similar transaction effected without receipt of consideration that
increases the number of outstanding shares of Registrant&#146;s Common Stock.


<P align="left" style="font-size: 10pt">(2)&nbsp;Estimated solely for the purpose of calculating the amount of the registration fee pursuant to
Rule 457(h) of the Securities Act. The price per share and aggregate offering price are based upon
the average of the high and low prices of Registrant&#146;s Common Stock on June&nbsp;20, 2005 as reported on
the Nasdaq National Market.


<P align="left" style="font-size: 10pt">(3)&nbsp;The Carried Forward Shares were previously registered under the Prior Registration Statements;
therefore, no filing fee with respect to those shares is required (Interpretation 89 under Section
G of the Securities and Exchange Commission Division of Corporate Finance Manual of Publicly
Available Telephone Interpretations (July&nbsp;1997) and Instruction E to the General Instructions to
Form S-8). The Post-Effective Amendments to the Prior Registration Statements are filed here to
reallocate the Carried Forward Shares from the Prior Registration Statements and to carry over the
registration fees paid for the Carried Forward Shares from the Prior Registration Statements.



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<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="76%"></TD>
</TR>
<TR><TD colspan="9"><A HREF="#000">EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="#001">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#002">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="f10144exv5w1.htm">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="f10144exv23w1.htm">EXHIBIT 23.1</A></TD></TR>
</TABLE>
</CENTER>
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<P align="center" style="font-size: 10pt"><B>STATEMENT PURSUANT TO GENERAL INSTRUCTION E TO FORM S-8</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Onyx Pharmaceuticals, Inc. (the &#147;Company&#148;) has filed this registration statement to register
under the Securities Act the offer and sale of 3,990,000 common shares, par value $0.001 per share,
of beneficial interest, not previously registered, in the Company,
and
up to 3,570,045 <!-- Insert HTML here --><!-- Insert HTML here --> common
shares, par value $0.001<!-- Insert HTML here --
<!-- Insert HTML here --> per share, which were previously
registered (as further described below) of beneficial interest in the
Company, <!-- Insert HTML here --><!-- Insert HTML here -->  pursuant to the Onyx Pharmaceuticals, Inc. 2005 Equity
Incentive Plan (the &#147;2005 Plan&#148;).
<!-- Insert HTML here --><!-- Insert HTML here --> This registration statement is (a)&nbsp;a new registration statement;
(b)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the 1996 Registration Statement; (c)&nbsp;a Post-Effective
Amendment No.&nbsp;1 to the 1997 Registration Statement; (d)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the
1998 Registration Statement; (e)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the 1999 Registration
Statement; (f)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the 2000 Registration Statement; (g)&nbsp;a
Post-Effective Amendment No.&nbsp;1 to the 2001 Registration Statement; (h)&nbsp;a Post-Effective Amendment
No.&nbsp;1 to the 2002 Registration Statement; (i)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the 2003
Registration Statement; and (j)&nbsp;a Post-Effective Amendment No.&nbsp;1 to the 2004 Registration
Statement (the 1996 Registration Statement, the 1997 Registration Statement, the 1998 Registration
Statement, the 1999 Registration Statement, the 2000 Registration Statement, the 2001 Registration
Statement, the 2002 Registration Statement, the 2003 Registration Statement, and the 2004
Registration Statement are collectively referred herein as the &#147;Prior Registration Statements&#148;).
3,570,045 shares registered hereby were previously registered under the Prior Registration
Statements for offer and sale pursuant to the Onyx Pharmaceuticals,
Inc. 1996 Equity Incentive Plan, as amended,
and the Onyx Pharmaceuticals, Inc. 1996 Non-Employee Directors&#146;
Stock Option Plan, as amended (collectively,
the &#147;Prior Plans&#148;).


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The 2005 Plan was approved and adopted at the Company&#146;s annual meeting of stockholders on June
1, 2005 to supersede and replace the Prior Plans. The Company desires to have the common shares
registered hereunder and issuable pursuant to the 2005 Plan to include those common shares
described above whose offer and sale were registered under the Prior Registration Statements. The
shares carried over from the Prior Registration Statements are no longer available for new awards
under the Prior Plans. This Registration Statement covers 3,990,000 shares, not previously
registered, under the 2005 Plan, which is the successor plan to the Prior Plans. In addition, this
Registration Statement covers up to 3,570,045 shares which were previously registered under the
Prior Registration Statements for offer or sale under the Prior Plans and which may be offered or
sold under the 2005 Plan (the &#147;Carried Forward Shares&#148;). The Carried Forward Shares consist of shares remaining available for issuance under the Prior Plans and shares
subject to currently outstanding options under the Prior Plans. In the event any of these shares
subject to outstanding options are not issued under the Prior Plans, such as when an option granted
under any Prior Plan is canceled without being exercised, such shares will become available for
issuance under the 2005 Plan. Pursuant to Rule 416(a) of the Securities Act, this Registration
Statement shall also cover any additional shares of the Company&#146;s Common Stock that become issuable
under the 2005 Plan and the Prior Plans by reason of any stock dividend, stock split,
recapitalization or other similar transaction effected without receipt of consideration that
increases the number of outstanding shares of the Company&#146;s Common Stock.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Consequently, in accordance with the Interpretation 89 under Section&nbsp;G of the Securities and
Exchange Commission Division of Corporate Finance Manual of Publicly Available Telephone
Interpretations (July&nbsp;1997) and Instruction E to the General Instructions to Form S-8: (a)&nbsp;the
Company is (i)&nbsp;carrying over the Carried Forward Shares from the Prior Registration Statements, and
(ii)&nbsp;registering the offer and sale of 3,990,000 new common shares, of which all 7,560,045 shares
may be offered and sold under the 2005 Plan pursuant to this registration statement; (b)&nbsp;the
registration fee allocable to the Carried Forward Shares carried over from the Prior Registration
Statements and paid in connection with the Prior Registration Statements is carried over in this
Registration Statement; and (c)&nbsp;the Prior Registration Statements are being amended on a
post-effective basis to disclose the succession of the 2005 Plan to the Prior Plans, pursuant to
this Registration Statement.


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<P align="center" style="font-size: 10pt"><B>INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by Onyx Pharmaceuticals, Inc. (the &#147;Company&#148;) with the
Securities and Exchange Commission (&#147;SEC&#148;) are incorporated by reference into this Registration
Statement on Form S-8:


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(a)&nbsp;</B>The Company&#146;s Annual Report on Form 10-K for the Company&#146;s fiscal year ended
December&nbsp;31, 2004, filed with the SEC on March&nbsp;16, 2005, as amended by the Form 10-K/A filed with
the SEC on March&nbsp;24, 2005.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(b)&nbsp;</B>The Company&#146;s Quarterly Report on Form 10-Q for the quarter ended March&nbsp;31, 2005,
filed with the SEC on May&nbsp;10, 2005.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(c)&nbsp;</B>The Company&#146;s proxy for the Company&#146;s stockholders&#146; meeting on June&nbsp;1, 2005 filed
with the SEC on April&nbsp;22, 2005.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(d)&nbsp;</B>The Company&#146;s Current Reports on Form 8-K filed with the SEC on March&nbsp;14, 2005,
March&nbsp;22, 2005, April&nbsp;18, 2005, May&nbsp;5, 2005, May&nbsp;16, 2005, and June&nbsp;7, 2005.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(e)&nbsp;</B>The description of the Company&#146;s Common Stock set forth in the Company&#146;s
registration statement on Form 8-A, filed with the SEC on April&nbsp;2, 1996, including any amendments
or reports filed for the purposes of updating this description.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(f)&nbsp;</B>All other reports filed pursuant to Sections 13(a) or 15(d) of the Securities
Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;) since the end of the fiscal year covered by
the annual reports, the prospectus or the registration statement referred to in (a)&nbsp;above.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents subsequently filed by the Company pursuant to Sections&nbsp;13(a),
13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment which
indicates that all securities offered have been sold or which deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this
registration statement from the date of the filing of such reports and documents.


<P align="center" style="font-size: 10pt"><B>DESCRIPTION OF SECURITIES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.


<P align="center" style="font-size: 10pt"><B>INTERESTS OF NAMED EXPERTS AND COUNSEL</B>


<P align="left" style="font-size: 10pt">As of June&nbsp;22, 2005, partners and associates of Cooley Godward LLP participating in the preparation
of this Registration Statement on Form S-8 owned an aggregate of 1,200 shares of the Company&#146;s
Common Stock.



<P align="center" style="font-size: 10pt"><B>INDEMNIFICATION OF DIRECTORS AND OFFICERS</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As permitted by Delaware law, the Company&#146;s amended and restated certificate of incorporation
provides that no director will be personally liable to the Company or the Company&#146;s stockholders
for monetary damages for breach of fiduciary duty as a director, except for liability:


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>for any breach of the duty of loyalty to the Company or the Company&#146;s
stockholders;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>for acts or omissions not in good faith or that involve intentional misconduct
or a knowing violation of law;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>for unlawful payment of dividends or unlawful stock repurchases or redemptions
under Section&nbsp;174 of the Delaware General Corporation Law; and</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>for any transaction from which the director derived an improper personal
benefit.</TD>
</TR>

</TABLE>

<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<P><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">



</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Company&#146;s amended and restated certificate of incorporation further provides that the
Company must indemnify the Company&#146;s directors to the fullest extent permitted by Delaware law. In
addition, the Company&#146;s amended and restated bylaws provide that:


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>the Company is required to indemnify the Company&#146;s directors and officers to the
fullest extent permitted by Delaware law, subject to limited exceptions;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>the Company may indemnify the Company&#146;s other employees and agents to the extent
that the Company indemnifies its officers and directors, unless otherwise
prohibited by law, the Company&#146;s amended and restated certificate of incorporation,
the Company&#146;s amended and restated bylaws or agreements;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>the Company is required to advance expenses to the Company&#146;s directors and
executive officers as incurred in connection with legal proceedings against them
for which they may be indemnified, against an undertaking by the indemnified party
to repay such advances if it is ultimately determined that the indemnified party is
not entitled to indemnification; and</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>the rights conferred in the amended and restated bylaws are not exclusive.</TD>
</TR>

</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Company has entered into indemnification agreements with each of the Company&#146;s directors
and executive officers that require the Company to indemnify these people against expenses,
judgments, fines and settlement amounts incurred by the director or officer in any action or
proceeding, whether actual or threatened, to which any of these people may be made a party by
reason of the fact that he or she is or was a director or an executive officer of the Company or
any of its affiliated enterprises, provided this person acted in good faith and in a manner he or
she reasonably believed to be in, or not opposed to, the best interest of the Company and, with
respect to any criminal proceeding, has no reasonable cause to believe his conduct was unlawful.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;At present, the Company is not aware of any pending or threatened litigation or proceeding
involving any of the Company&#146;s directors, officers, employees or agents in which indemnification
would be required or permitted. The Company believes that the Company&#146;s charter provisions and
indemnification agreements are necessary to attract and retain qualified persons as directors and
officers.


<P align="center" style="font-size: 10pt"><B>EXEMPTION FROM REGISTRATION CLAIMED</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link1 "EXHIBITS" -->
<DIV align="left"><A NAME="000"></A></DIV>

<P align="center" style="font-size: 10pt"><B>EXHIBITS</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="4%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="94%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Number</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Description</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Restated Certificate of Incorporation(1)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Certificate of Amendment to Amended and Restated Certificate of Incorporation(2)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Bylaws of the Company(1)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Stock Certificate(1)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Cooley Godward <FONT style="font-variant: SMALL-CAPS">llp</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Independent Registered Public Accounting Firm</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Cooley Godward <FONT style="font-variant: SMALL-CAPS">llp- C</FONT>ontained in Opinion of Cooley Godward
<FONT style="font-variant: SMALL-CAPS">llp</FONT> filed as Exhibit&nbsp;5.1 to this Registration Statement</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney- Contained on the signature pages</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Onyx Pharmaceuticals, Inc. 1996 Equity Incentive Plan(3)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Onyx Pharmaceuticals, Inc. 1996 Non-Employee Directors&#146; Stock Option Plan(4)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Onyx Pharmaceuticals, Inc. 2005 Equity Incentive Plan(5)</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="3%" nowrap align="left">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Company&#146;s Registration Statement on Form&nbsp;SB-2 (No.
333-3176-LA).</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Company&#146;s Quarterly Report on Form 10-Q for the quarter
ended June&nbsp;30, 2000.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(3)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Company&#146;s Registration Statement on Form S-8 filed with
the SEC on November&nbsp;9, 2004 (No.&nbsp;333-120324).</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(4)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Company&#146;s Registration Statement on Form S-8 filed with
the SEC on November&nbsp;13, 2003 (No.&nbsp;333-110469).</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(5)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Company&#146;s Current Report on Form 8-K filed with the SEC on
June&nbsp;7, 2005.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">






<P align="center" style="font-size: 10pt"><B>UNDERTAKINGS</B>



<P align="left" style="font-size: 10pt"><B>1. </B>The undersigned registrant hereby undertakes:



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(a)&nbsp;</B>To file, during any period in which offers or sales are being made, a post-effective
amendment to this registration statement:


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(i)&nbsp;</B>To include any prospectus required by section 10(a)(3) of the Securities Act;


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(ii)&nbsp;</B>To reflect in the prospectus any facts or events arising after the effective date of the
registration statement (or the most recent post-effective amendment thereof) which, individually or
in the aggregate, represent a fundamental change in the information set forth in the registration
statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
(if the total dollar value of securities offered would not exceed that which was registered) and
any deviation from the low or high end of the estimated maximum offering range may be reflected in
the form of prospectus filed with the Commission pursuant to Rule 424(b) (&#167; 230.424(b) of this
chapter) if, in the aggregate, the changes in volume and price represent no more than a 20% change
in the maximum aggregate offering price set forth in the &#147;Calculation of Registration Fee&#148; table in
the effective registration statement.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(iii)&nbsp;</B>To include any material information with respect to the plan of distribution not
previously disclosed in the registration statement or any material change to such information in
the registration statement;


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>provided, however, </I>that paragraphs (a)(i) and (a)(ii) do not apply if the information required
to be included in a post-effective amendment by those paragraphs is contained in periodic reports
filed by the issuer pursuant to section 13 or section 15(d) of the Exchange Act that are
incorporated by reference herein.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(b)&nbsp;</B>That, for the purpose of determining any liability under the Securities Act, each such
post-effective amendment shall be deemed to be a new registration statement relating to the
securities offered herein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(c)&nbsp;</B>To remove from registration by means of a post-effective amendment any of the securities
being registered which remain unsold at the termination of the offering.


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><B>2.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The undersigned registrant hereby undertakes that, for purposes of determining any liability
under the Securities Act, each filing of the registrant&#146;s annual report pursuant to Section
13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee
benefit plan&#146;s annual report pursuant to section 15(d) of the Exchange Act) that is
incorporated by reference in the Registration Statement shall be deemed to be a new
registration statement relating to the securities offered herein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering thereof.</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><B>3.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Insofar as indemnification for liabilities arising under the Securities Act may be permitted
to directors, officers and controlling persons of the registrant pursuant to the foregoing
provisions, or otherwise, the registrant has been advised that in the opinion of the SEC such
indemnification is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such liabilities (other
than the payment by the registrant of expenses incurred or paid by a director, officer or
controlling person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the registrant will, unless in the opinion of its counsel the
matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as
expressed in the Securities Act and will be governed by the final adjudication of such issue.</TD>
</TR>

</TABLE>

<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<P><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">



</TABLE>

<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="001"></A></DIV>

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of Emeryville, State of California, on June
23, 2005.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="48%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="45%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" valign="top" align="left"><FONT style="font-variant: SMALL-CAPS">ONYX PHARMACEUTICALS, INC.</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">/s/ HOLLINGS C. RENTON</TD>
</TR>
<TR style="font-size: 1px">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Hollings C. Renton</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><I>Chairman of the Board,</I></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><I>President and Chief Executive Officer</I></TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT style="font-variant: SMALL-CAPS"><B>Know All Persons By These Presents</B>,</FONT> that each person whose signature appears below
constitutes and appoints Hollings C. Renton and Marilyn E. Wortzman or either of them, his or her
true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for
him and in his name, place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) to this Registration Statement, and to file the same, with
all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and necessary to be done in
connection therewith, as fully to all intents and purposes as he might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or
their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities and on the dates indicated.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="38%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="43%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
</TR>

<!-- End Table Head -->
<P>
<!-- Begin Table Body -->

<TR valign="bottom">
    <TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Hollings C. Renton
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Chairman of the Board, President and
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;23, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Chief Executive Officer</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Hollings C. Renton
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><I>(Principal Executive and Financial Officer)</I></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Marilyn E. Wortzman
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Vice <I>President</I>, Finance and Administration
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;23, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><I>(Principal Accounting Officer)</I></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Marilyn E. Wortzman</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Paul Goddard, Ph.D.</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;23, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Paul Goddard, Ph.D.</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Antonio Grillo-L&#243;pez, M.D.</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;23, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Antonio Grillo-L&#243;pez, M.D.</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Magnus Lundberg</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;23, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Magnus Lundberg</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Nicole Vitullo</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;23, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Nicole Vitullo</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Wendell Wierenga, Ph.D.</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;23, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Wendell Wierenga, Ph.D.</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/ Thomas Wiggans</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><HR size="1" noshade color="#000000">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">June&nbsp;23, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Thomas Wiggans</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="002"></A></DIV>

<P align="center" style="font-size: 10pt"><B>EXHIBIT INDEX</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="4%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="94%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Number</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Description</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Restated Certificate of Incorporation(1)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Certificate of Amendment to Amended and Restated Certificate of Incorporation(2)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Bylaws of the Company(1)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Stock Certificate(1)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Cooley Godward <FONT style="font-variant: SMALL-CAPS">llp</FONT></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Independent Registered Public Accounting Firm</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Cooley Godward <FONT style="font-variant: SMALL-CAPS">llp- C</FONT>ontained in Opinion of Cooley Godward
<FONT style="font-variant: SMALL-CAPS">llp</FONT> filed as Exhibit&nbsp;5.1 to this Registration Statement</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney- Contained on the signature pages</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>

</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Onyx Pharmaceuticals, Inc. 1996 Equity Incentive Plan(3)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Onyx Pharmaceuticals, Inc. 1996 Non-Employee Directors&#146; Stock Option Plan(4)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">99.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Onyx Pharmaceuticals, Inc. 2005 Equity Incentive Plan(5)</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="3%" nowrap align="left">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Company&#146;s Registration Statement on Form&nbsp;SB-2 (No.
333-3176-LA).</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Company&#146;s Quarterly Report on Form 10-Q for the quarter
ended June&nbsp;30, 2000.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(3)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Company&#146;s Registration Statement on Form S-8 filed with
the SEC on November&nbsp;9, 2004 (No.&nbsp;333-120324).</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(4)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Company&#146;s Registration Statement on Form S-8 filed with
the SEC on November&nbsp;13, 2003 (No.&nbsp;333-110469).</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(5)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Filed as an exhibit to the Company&#146;s Current Report on Form 8-K filed with the SEC on
June&nbsp;7, 2005.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

</BODY>
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sv8
Table of Contents
As filed with the Securities and Exchange Commission on June 23, 2005
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
AND
POST-EFFECTIVE AMENDMENT NO. 1 TO
REGISTRATION STATEMENTS
NO. 333-04839, NO. 333-34681, NO. 333-60805, NO. 333-84113, 333-48146, NO. 333-64706, 333-96895, 333-110469, AND 333-120324
UNDER
THE SECURITIES ACT OF 1933
ONYX PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)
Delaware
94-3154463
(State of Incorporation)
(I.R.S. Employer Identification No.)
2100 Powell Street
Emeryville, California 94608
(Address of principal executive offices)
2005
EQUITY INCENTIVE PLAN
1996  EQUITY INCENTIVE PLAN
1996  NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN
(Full title of the plans)
Hollings C. Renton
Chairman of the Board, President and Chief Executive Officer
Onyx Pharmaceuticals, Inc.
2100 Powell Street
Emeryville, California 94608
(510) 597-6500
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
Robert L. Jones, Esq.
Laura A. Berezin, Esq.
Cooley Godward LLP
Five Palo Alto Square
3000 El Camino Real
Palo Alto, California 94306-2155
(650) 843-5000
Table of Contents
CALCULATION OF REGISTRATION FEE
Proposed Maximum
Proposed Maximum
Title of Securities
Amount to be
Offering
Aggregate
Amount of
to be Registered
Registered
Price per Share
Offering Price
Registration Fee
Common Stock, par value
$0.001 per share
Shares not
previously
registered
3,990,000
(1)
$26.39
(2)
$105,296,100
(2)
$12,394
(2)
Shares previously
registered
3,570,045
(1)
N/A
(3)
N/A
(3)
N/A
(3)
This registration statement is (a) a new registration statement; (b) a Post-Effective Amendment No.
1 to the registrant's registration statement on Form S-8 (File No. 333-04839), as filed with the
Securities and Exchange Commission on May 30, 1996 (the "1996 Registration Statement"); (c) a
Post-Effective Amendment No. 1 to the registrant's registration statement on Form S-8 (File No.
333-34681), as filed with the Securities and Exchange Commission on August 29, 1997 (the "1997
Registration Statement"); (d) a Post-Effective Amendment No. 1 to the registrant's registration
statement on Form S-8 (File No. 333-60805), as filed with the Securities and Exchange Commission on
August 6, 1998 (the "1998 Registration Statement"); (e) a Post-Effective Amendment No. 1 to the
registrant's registration statement on Form S-8 (File No. 333-84113), as filed with the Securities
and Exchange Commission on July 30, 1999 (the "1999 Registration Statement"); (f) a Post-Effective
Amendment No. 1 to the registrant's registration statement on Form S-8 (File No. 333-48146), as
filed with the Securities and Exchange Commission on October 18, 2000 (the "2000 Registration
Statement"); (g) a Post-Effective Amendment No. 1 to the registrant's registration statement on
Form S-8 (File No. 333-64706), as filed with the Securities and Exchange Commission on July 6, 2001
(the "2001 Registration Statement"); (h) a Post-Effective Amendment No. 1 to the registrant's
registration statement on Form S-8 (File No. 333-96895), as filed with the Securities and Exchange
Commission on July 22, 2002 (the "2002 Registration Statement"); (i) a Post-Effective Amendment
No. 1 to the registrant's registration statement on Form S-8 (File No. 333-110469), as filed with
the Securities and Exchange Commission on November 13, 2003 (the "2003 Registration Statement");
and (j) a Post-Effective Amendment No. 1 to the registrant's registration statement on Form S-8
(File No. 333-120324), as filed with the Securities and Exchange Commission on November 9, 2004
(the "2004 Registration Statement") (the 1996 Registration Statement, the 1997 Registration
Statement, the 1998 Registration Statement, the 1999 Registration Statement, the 2000 Registration
Statement, the 2001 Registration Statement, the 2002 Registration Statement, the 2003 Registration
Statement, and the 2004 Registration Statement are collectively referred herein as the "Prior
Registration Statements"). Pursuant to the Prior Registration Statements, shares of common stock,
par value $0.001, were registered for issuance under the Onyx Pharmaceuticals, Inc. 1996 Equity
Incentive Plan, as amended, and the Onyx Pharmaceuticals, Inc. 1996
Non-Employee Directors' Stock Option Plan, as amended (collectively, the "Prior Plans").
(1) This Registration Statement covers 3,990,000 shares, not previously registered, under the Onyx
Pharmaceuticals, Inc. 2005 Equity Incentive Plan (the "2005 Plan"), which is the successor plan to
the Prior Plans. In addition, this Registration Statement covers up to 3,570,045 shares which were
previously registered under the Prior Registration Statements for offer or sale under the Prior
Plans and which may be offered or sold under the 2005 Plan (the "Carried Forward Shares"). The
Carried Forward Shares consist of shares remaining available for issuance under the
Prior Plans and shares subject to currently outstanding options under the Prior
Plans. In the event any of these shares subject to outstanding options are not issued under the
Prior Plans, such as when an option granted under any Prior Plan is canceled without being
exercised, such shares will become available for issuance under the 2005 Plan. Pursuant to Rule
416(a) of the Securities Act of 1933, as amended (the "Securities Act"), this Registration
Statement shall also cover any additional shares of Registrant's Common Stock that become issuable
under the 2005 Plan and the Prior Plans by reason of any stock dividend, stock split,
recapitalization or other similar transaction effected without receipt of consideration that
increases the number of outstanding shares of Registrant's Common Stock.
(2) Estimated solely for the purpose of calculating the amount of the registration fee pursuant to
Rule 457(h) of the Securities Act. The price per share and aggregate offering price are based upon
the average of the high and low prices of Registrant's Common Stock on June 20, 2005 as reported on
the Nasdaq National Market.
(3) The Carried Forward Shares were previously registered under the Prior Registration Statements;
therefore, no filing fee with respect to those shares is required (Interpretation 89 under Section
G of the Securities and Exchange Commission Division of Corporate Finance Manual of Publicly
Available Telephone Interpretations (July 1997) and Instruction E to the General Instructions to
Form S-8). The Post-Effective Amendments to the Prior Registration Statements are filed here to
reallocate the Carried Forward Shares from the Prior Registration Statements and to carry over the
registration fees paid for the Carried Forward Shares from the Prior Registration Statements.
TABLE OF CONTENTS
EXHIBITS
SIGNATURES
EXHIBIT INDEX
EXHIBIT 5.1
EXHIBIT 23.1
Table of Contents
STATEMENT PURSUANT TO GENERAL INSTRUCTION E TO FORM S-8
Onyx Pharmaceuticals, Inc. (the "Company") has filed this registration statement to register
under the Securities Act the offer and sale of 3,990,000 common shares, par value $0.001 per share,
of beneficial interest, not previously registered, in the Company,
and
up to 3,570,045
common
shares, par value $0.001
per share, which were previously
registered (as further described below) of beneficial interest in the
Company,
pursuant to the Onyx Pharmaceuticals, Inc. 2005 Equity
Incentive Plan (the "2005 Plan").
This registration statement is (a) a new registration statement;
(b) a Post-Effective Amendment No. 1 to the 1996 Registration Statement; (c) a Post-Effective
Amendment No. 1 to the 1997 Registration Statement; (d) a Post-Effective Amendment No. 1 to the
1998 Registration Statement; (e) a Post-Effective Amendment No. 1 to the 1999 Registration
Statement; (f) a Post-Effective Amendment No. 1 to the 2000 Registration Statement; (g) a
Post-Effective Amendment No. 1 to the 2001 Registration Statement; (h) a Post-Effective Amendment
No. 1 to the 2002 Registration Statement; (i) a Post-Effective Amendment No. 1 to the 2003
Registration Statement; and (j) a Post-Effective Amendment No. 1 to the 2004 Registration
Statement (the 1996 Registration Statement, the 1997 Registration Statement, the 1998 Registration
Statement, the 1999 Registration Statement, the 2000 Registration Statement, the 2001 Registration
Statement, the 2002 Registration Statement, the 2003 Registration Statement, and the 2004
Registration Statement are collectively referred herein as the "Prior Registration Statements").
3,570,045 shares registered hereby were previously registered under the Prior Registration
Statements for offer and sale pursuant to the Onyx Pharmaceuticals,
Inc. 1996 Equity Incentive Plan, as amended,
and the Onyx Pharmaceuticals, Inc. 1996 Non-Employee Directors'
Stock Option Plan, as amended (collectively,
the "Prior Plans").
The 2005 Plan was approved and adopted at the Company's annual meeting of stockholders on June
1, 2005 to supersede and replace the Prior Plans. The Company desires to have the common shares
registered hereunder and issuable pursuant to the 2005 Plan to include those common shares
described above whose offer and sale were registered under the Prior Registration Statements. The
shares carried over from the Prior Registration Statements are no longer available for new awards
under the Prior Plans. This Registration Statement covers 3,990,000 shares, not previously
registered, under the 2005 Plan, which is the successor plan to the Prior Plans. In addition, this
Registration Statement covers up to 3,570,045 shares which were previously registered under the
Prior Registration Statements for offer or sale under the Prior Plans and which may be offered or
sold under the 2005 Plan (the "Carried Forward Shares"). The Carried Forward Shares consist of shares remaining available for issuance under the Prior Plans and shares
subject to currently outstanding options under the Prior Plans. In the event any of these shares
subject to outstanding options are not issued under the Prior Plans, such as when an option granted
under any Prior Plan is canceled without being exercised, such shares will become available for
issuance under the 2005 Plan. Pursuant to Rule 416(a) of the Securities Act, this Registration
Statement shall also cover any additional shares of the Company's Common Stock that become issuable
under the 2005 Plan and the Prior Plans by reason of any stock dividend, stock split,
recapitalization or other similar transaction effected without receipt of consideration that
increases the number of outstanding shares of the Company's Common Stock.
Consequently, in accordance with the Interpretation 89 under Section G of the Securities and
Exchange Commission Division of Corporate Finance Manual of Publicly Available Telephone
Interpretations (July 1997) and Instruction E to the General Instructions to Form S-8: (a) the
Company is (i) carrying over the Carried Forward Shares from the Prior Registration Statements, and
(ii) registering the offer and sale of 3,990,000 new common shares, of which all 7,560,045 shares
may be offered and sold under the 2005 Plan pursuant to this registration statement; (b) the
registration fee allocable to the Carried Forward Shares carried over from the Prior Registration
Statements and paid in connection with the Prior Registration Statements is carried over in this
Registration Statement; and (c) the Prior Registration Statements are being amended on a
post-effective basis to disclose the succession of the 2005 Plan to the Prior Plans, pursuant to
this Registration Statement.
Table of Contents
INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
The following documents filed by Onyx Pharmaceuticals, Inc. (the "Company") with the
Securities and Exchange Commission ("SEC") are incorporated by reference into this Registration
Statement on Form S-8:
(a)
The Company's Annual Report on Form 10-K for the Company's fiscal year ended
December 31, 2004, filed with the SEC on March 16, 2005, as amended by the Form 10-K/A filed with
the SEC on March 24, 2005.
(b)
The Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 2005,
filed with the SEC on May 10, 2005.
(c)
The Company's proxy for the Company's stockholders' meeting on June 1, 2005 filed
with the SEC on April 22, 2005.
(d)
The Company's Current Reports on Form 8-K filed with the SEC on March 14, 2005,
March 22, 2005, April 18, 2005, May 5, 2005, May 16, 2005, and June 7, 2005.
(e)
The description of the Company's Common Stock set forth in the Company's
registration statement on Form 8-A, filed with the SEC on April 2, 1996, including any amendments
or reports filed for the purposes of updating this description.
(f)
All other reports filed pursuant to Sections 13(a) or 15(d) of the Securities
Exchange Act of 1934, as amended (the "Exchange Act") since the end of the fiscal year covered by
the annual reports, the prospectus or the registration statement referred to in (a) above.
All reports and other documents subsequently filed by the Company pursuant to Sections 13(a),
13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment which
indicates that all securities offered have been sold or which deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this
registration statement from the date of the filing of such reports and documents.
DESCRIPTION OF SECURITIES
Not applicable.
INTERESTS OF NAMED EXPERTS AND COUNSEL
As of June 22, 2005, partners and associates of Cooley Godward LLP participating in the preparation
of this Registration Statement on Form S-8 owned an aggregate of 1,200 shares of the Company's
Common Stock.
INDEMNIFICATION OF DIRECTORS AND OFFICERS
As permitted by Delaware law, the Company's amended and restated certificate of incorporation
provides that no director will be personally liable to the Company or the Company's stockholders
for monetary damages for breach of fiduciary duty as a director, except for liability:
•
for any breach of the duty of loyalty to the Company or the Company's
stockholders;
•
for acts or omissions not in good faith or that involve intentional misconduct
or a knowing violation of law;
•
for unlawful payment of dividends or unlawful stock repurchases or redemptions
under Section 174 of the Delaware General Corporation Law; and
•
for any transaction from which the director derived an improper personal
benefit.
Table of Contents
The Company's amended and restated certificate of incorporation further provides that the
Company must indemnify the Company's directors to the fullest extent permitted by Delaware law. In
addition, the Company's amended and restated bylaws provide that:
•
the Company is required to indemnify the Company's directors and officers to the
fullest extent permitted by Delaware law, subject to limited exceptions;
•
the Company may indemnify the Company's other employees and agents to the extent
that the Company indemnifies its officers and directors, unless otherwise
prohibited by law, the Company's amended and restated certificate of incorporation,
the Company's amended and restated bylaws or agreements;
•
the Company is required to advance expenses to the Company's directors and
executive officers as incurred in connection with legal proceedings against them
for which they may be indemnified, against an undertaking by the indemnified party
to repay such advances if it is ultimately determined that the indemnified party is
not entitled to indemnification; and
•
the rights conferred in the amended and restated bylaws are not exclusive.
The Company has entered into indemnification agreements with each of the Company's directors
and executive officers that require the Company to indemnify these people against expenses,
judgments, fines and settlement amounts incurred by the director or officer in any action or
proceeding, whether actual or threatened, to which any of these people may be made a party by
reason of the fact that he or she is or was a director or an executive officer of the Company or
any of its affiliated enterprises, provided this person acted in good faith and in a manner he or
she reasonably believed to be in, or not opposed to, the best interest of the Company and, with
respect to any criminal proceeding, has no reasonable cause to believe his conduct was unlawful.
At present, the Company is not aware of any pending or threatened litigation or proceeding
involving any of the Company's directors, officers, employees or agents in which indemnification
would be required or permitted. The Company believes that the Company's charter provisions and
indemnification agreements are necessary to attract and retain qualified persons as directors and
officers.
EXEMPTION FROM REGISTRATION CLAIMED
Not applicable.
Table of Contents
EXHIBITS
Exhibit
Number
Description
4.1
Restated Certificate of Incorporation(1)
4.2
Certificate of Amendment to Amended and Restated Certificate of Incorporation(2)
4.3
Bylaws of the Company(1)
4.4
Specimen Stock Certificate(1)
5.1
Opinion of Cooley Godward
llp
23.1
Consent of Independent Registered Public Accounting Firm
23.2
Consent of Cooley Godward
llp- C
ontained in Opinion of Cooley Godward
llp
filed as Exhibit 5.1 to this Registration Statement
24
Power of Attorney- Contained on the signature pages
99.1
Onyx Pharmaceuticals, Inc. 1996 Equity Incentive Plan(3)
99.2
Onyx Pharmaceuticals, Inc. 1996 Non-Employee Directors' Stock Option Plan(4)
99.3
Onyx Pharmaceuticals, Inc. 2005 Equity Incentive Plan(5)
(1)
Filed as an exhibit to the Company's Registration Statement on Form SB-2 (No.
333-3176-LA).
(2)
Filed as an exhibit to the Company's Quarterly Report on Form 10-Q for the quarter
ended June 30, 2000.
(3)
Filed as an exhibit to the Company's Registration Statement on Form S-8 filed with
the SEC on November 9, 2004 (No. 333-120324).
(4)
Filed as an exhibit to the Company's Registration Statement on Form S-8 filed with
the SEC on November 13, 2003 (No. 333-110469).
(5)
Filed as an exhibit to the Company's Current Report on Form 8-K filed with the SEC on
June 7, 2005.
Table of Contents
UNDERTAKINGS
1.
The undersigned registrant hereby undertakes:
(a)
To file, during any period in which offers or sales are being made, a post-effective
amendment to this registration statement:
(i)
To include any prospectus required by section 10(a)(3) of the Securities Act;
(ii)
To reflect in the prospectus any facts or events arising after the effective date of the
registration statement (or the most recent post-effective amendment thereof) which, individually or
in the aggregate, represent a fundamental change in the information set forth in the registration
statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered
(if the total dollar value of securities offered would not exceed that which was registered) and
any deviation from the low or high end of the estimated maximum offering range may be reflected in
the form of prospectus filed with the Commission pursuant to Rule 424(b) (§ 230.424(b) of this
chapter) if, in the aggregate, the changes in volume and price represent no more than a 20% change
in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in
the effective registration statement.
(iii)
To include any material information with respect to the plan of distribution not
previously disclosed in the registration statement or any material change to such information in
the registration statement;
provided, however,
that paragraphs (a)(i) and (a)(ii) do not apply if the information required
to be included in a post-effective amendment by those paragraphs is contained in periodic reports
filed by the issuer pursuant to section 13 or section 15(d) of the Exchange Act that are
incorporated by reference herein.
(b)
That, for the purpose of determining any liability under the Securities Act, each such
post-effective amendment shall be deemed to be a new registration statement relating to the
securities offered herein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.
(c)
To remove from registration by means of a post-effective amendment any of the securities
being registered which remain unsold at the termination of the offering.
2.
The undersigned registrant hereby undertakes that, for purposes of determining any liability
under the Securities Act, each filing of the registrant's annual report pursuant to Section
13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee
benefit plan's annual report pursuant to section 15(d) of the Exchange Act) that is
incorporated by reference in the Registration Statement shall be deemed to be a new
registration statement relating to the securities offered herein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering thereof.
3.
Insofar as indemnification for liabilities arising under the Securities Act may be permitted
to directors, officers and controlling persons of the registrant pursuant to the foregoing
provisions, or otherwise, the registrant has been advised that in the opinion of the SEC such
indemnification is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such liabilities (other
than the payment by the registrant of expenses incurred or paid by a director, officer or
controlling person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the registrant will, unless in the opinion of its counsel the
matter has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public policy as
expressed in the Securities Act and will be governed by the final adjudication of such issue.
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the requirements for
filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of Emeryville, State of California, on June
23, 2005.
ONYX PHARMACEUTICALS, INC.
By:
/s/ HOLLINGS C. RENTON
Hollings C. Renton
Chairman of the Board,
President and Chief Executive Officer
Table of Contents
POWER OF ATTORNEY
Know All Persons By These Presents
,
that each person whose signature appears below
constitutes and appoints Hollings C. Renton and Marilyn E. Wortzman or either of them, his or her
true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for
him and in his name, place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) to this Registration Statement, and to file the same, with
all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and necessary to be done in
connection therewith, as fully to all intents and purposes as he might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or
their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Hollings C. Renton
Chairman of the Board, President and
June 23, 2005
Chief Executive Officer
Hollings C. Renton
(Principal Executive and Financial Officer)
/s/ Marilyn E. Wortzman
Vice
President
, Finance and Administration
June 23, 2005
(Principal Accounting Officer)
Marilyn E. Wortzman
/s/ Paul Goddard, Ph.D.
Director
June 23, 2005
Paul Goddard, Ph.D.
/s/ Antonio Grillo-López, M.D.
Director
June 23, 2005
Antonio Grillo-López, M.D.
/s/ Magnus Lundberg
Director
June 23, 2005
Magnus Lundberg
/s/ Nicole Vitullo
Director
June 23, 2005
Nicole Vitullo
/s/ Wendell Wierenga, Ph.D.
Director
June 23, 2005
Wendell Wierenga, Ph.D.
/s/ Thomas Wiggans
Director
June 23, 2005
Thomas Wiggans
Table of Contents
EXHIBIT INDEX
Exhibit
Number
Description
4.1
Restated Certificate of Incorporation(1)
4.2
Certificate of Amendment to Amended and Restated Certificate of Incorporation(2)
4.3
Bylaws of the Company(1)
4.4
Specimen Stock Certificate(1)
5.1
Opinion of Cooley Godward
llp
23.1
Consent of Independent Registered Public Accounting Firm
23.2
Consent of Cooley Godward
llp- C
ontained in Opinion of Cooley Godward
llp
filed as Exhibit 5.1 to this Registration Statement
24
Power of Attorney- Contained on the signature pages
99.1
Onyx Pharmaceuticals, Inc. 1996 Equity Incentive Plan(3)
99.2
Onyx Pharmaceuticals, Inc. 1996 Non-Employee Directors' Stock Option Plan(4)
99.3
Onyx Pharmaceuticals, Inc. 2005 Equity Incentive Plan(5)
(1)
Filed as an exhibit to the Company's Registration Statement on Form SB-2 (No.
333-3176-LA).
(2)
Filed as an exhibit to the Company's Quarterly Report on Form 10-Q for the quarter
ended June 30, 2000.
(3)
Filed as an exhibit to the Company's Registration Statement on Form S-8 filed with
the SEC on November 9, 2004 (No. 333-120324).
(4)
Filed as an exhibit to the Company's Registration Statement on Form S-8 filed with
the SEC on November 13, 2003 (No. 333-110469).
(5)
Filed as an exhibit to the Company's Current Report on Form 8-K filed with the SEC on
June 7, 2005.