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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<DIV style="font-family: 'Times New Roman',Times,serif">



<P align="center" style="font-size: 10pt">As filed with the Securities and Exchange Commission on March&nbsp;15, 2005



<P align="right" style="font-size: 10pt">Registration No.&nbsp;333-_____



<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>






<P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>

<P align="center" style="font-size: 18pt"><B>FORM S-8</B>

<DIV align="center" style="font-size: 10pt"><B>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</B></DIV>


<P align="center" style="font-size: 24pt"><B>INTROGEN THERAPEUTICS, INC.</B>


<DIV align="center" style="font-size: 10pt"><B>(Exact name of Registrant as specified in its charter)</B></DIV>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>
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<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top"><B>Delaware</B><BR>
<B><I>(State or other jurisdiction of<BR>
incorporation or organization)</I></B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>74-2704230</B><BR>
<B><I>(I.R.S. Employer Identification Number)</I></B></TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><B>301 Congress Avenue, Suite&nbsp;1850<BR>
Austin, Texas 78701<BR>
(512)&nbsp;708-9310<BR>
(Address, including zip code, and telephone number, including area code, of<BR>
Registrant&#146;s principal executive offices)</B>



<P align="center" style="font-size: 10pt"><B>2000 STOCK OPTION PLAN<BR>
(Full title of the plan)</B>



<P align="center" style="font-size: 10pt"><B>David G. Nance<BR>
Chief Executive Officer<BR>
INTROGEN THERAPEUTICS, INC.<BR>
301 Congress Avenue, Suite&nbsp;1850<BR>
Austin, Texas 78701<BR>
(512)&nbsp;708-9310<BR>
(Name, address, including zip code, and telephone number, including area code, of agent for service)</B>



<P align="center" style="font-size: 10pt"><I>Copy to:</I><BR>
<B>Christopher J. Ozburn, Esq.<BR>
Wilson Sonsini Goodrich &#038; Rosati<BR>
Professional Corporation<BR>
8911 Capital of Texas Highway N.<BR>
Westech 360, Suite&nbsp;3350<BR>
Austin, TX 78759-7247</B>



<P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="48%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Proposed</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Proposed</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Amount</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Amount of</B></TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>of Shares to be</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Offering</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Aggregate</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2"><B>Registration</B></TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Title of Securities to be Registered</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2" style="border-bottom: 1px solid #000000"><B>Registered (1)</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2" style="border-bottom: 1px solid #000000"><B>Price Per Share (2)</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2" style="border-bottom: 1px solid #000000"><B>Offering Price</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2" style="border-bottom: 1px solid #000000"><B>Fee</B></TD>
    <TD>&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">2000 Stock Option Plan Common
Stock, $0.001 par value (options
available for future grant)</DIV></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">1,531,140</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">$</TD>
    <TD align="right">6.96</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">$</TD>
    <TD align="right">10,656,734.40</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">$</TD>
    <TD align="right">1,254.30</TD>
    <TD>&nbsp;</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>








<P align="center" style="font-size: 10pt">&nbsp;</DIV>

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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(1)&nbsp;&nbsp;</TD>
    <TD>This Registration Statement shall also cover any additional shares of Common Stock which
become issuable under the 2000 Stock Option Plan by reason of any stock dividend, stock split,
recapitalization or any other similar transaction effected without the receipt of
consideration that results in an increase in the number of the Registrant&#146;s outstanding shares
of Common Stock.</TD>
</TR>

</TABLE>


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(2)&nbsp;&nbsp;</TD>
    <TD>The proposed maximum offering price per share has been estimated in accordance with Rule
457(c) under the Securities Act of 1933, as amended (the &#147;Securities Act&#148;) as to the 1,531,140
additional shares of Common Stock authorized for issuance pursuant to the 2000 Stock Option
Plan, solely for the purpose of calculating the registration fee. No options have been granted
with respect to such shares. The computation is based upon the average of the high and low
price of the Common Stock as reported on the Nasdaq National Market on March 9, 2005, because
the price at which the options to be granted in the future may be exercised is not currently
determinable.</TD>
</TR>

</TABLE>



<P align="center" style="font-size: 10pt">&nbsp;</DIV>

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<!-- TOC -->
<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

<P><CENTER>
<TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
<TR>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
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	<TD width="3%"></TD>
	<TD width="3%"></TD>
	<TD width="76%"></TD>
</TR>
<TR><TD colspan="9"><A HREF="#000">PART II</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;8. Exhibits.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#002">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">POWER OF ATTORNEY</A></TD></TR>
<TR><TD colspan="9"><A HREF="#004">INDEX TO EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="d23399exv5w1.htm">Opinion of Counsel</A></TD></TR>
<TR><TD colspan="9"><A HREF="d23399exv23w1.htm">Consent of Independent Registered Public Accounting Firm</A></TD></TR>
</TABLE>
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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>







<P align="center" style="font-size: 10pt">INTROGEN THERAPEUTICS, INC.<BR>
REGISTRATION STATEMENT ON FORM S-8



<P align="left" style="font-size: 10pt">STATEMENT UNDER GENERAL INSTRUCTION E &#151; REGISTRATION OF ADDITIONAL SECURITIES



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement on Form S-8 is being filed for the purpose of registering an
additional 1,531,140 shares of the Registrant&#146;s Common Stock to be issued pursuant to the
Registrant&#146;s 2000 Stock Option Plan (the &#147;Plan&#148;). The contents of (i)&nbsp;the Registrant&#146;s Form S-8
Registration Statement filed with the Securities and Exchange Commission on March&nbsp;5, 2004
(Commission File No.&nbsp;333-113299) relating to the Plan, (ii)&nbsp;the Registrant&#146;s Form S-8 Registration
Statement filed with the Securities and Exchange Commission on April&nbsp;23, 2003 (Commission File No.
333-104697) relating to the Plan, (iii)&nbsp;the Registrant&#146;s Form S-8 Registration Statement filed with
the Securities and Exchange Commission on February&nbsp;4, 2002 (Commission File No.&nbsp;333-82122) relating
to the Plan, and (iv)&nbsp;the Registrant&#146;s Form S-8 Registration Statement filed with the Securities
and Exchange Commission on April&nbsp;10, 2001 (Commission File No.&nbsp;333-58648) relating to the Plan
(collectively, the &#147;Filed Form S-8&#146;s&#148;), including periodic filings updating or amending the
contents of the Filed Form S-8&#146;s, are incorporated by reference into this Registration Statement
pursuant to General Instruction E of Form S-8.

<!-- link1 "PART II" -->
<DIV align="left"><A NAME="000"></A></DIV>

<P align="center" style="font-size: 10pt">PART II



<P align="center" style="font-size: 10pt">INFORMATION REQUIRED IN REGISTRATION STATEMENT


<!-- link2 "Item&nbsp;8. Exhibits." -->
<DIV align="left"><A NAME="001"></A></DIV>

<P align="left" style="font-size: 10pt">Item&nbsp;8. Exhibits.



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Exhibits listed on the accompanying Index to Exhibits are filed as part hereof, or
incorporated by reference into, this Registration Statement. (See Index to Exhibits below)


<P align="center" style="font-size: 10pt">II-3</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="002"></A></DIV>

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant,
Introgen Therapeutics, Inc., certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be
signed on its behalf by the undersigned, thereunto duly authorized, in the City of Austin, State of
Texas, on March&nbsp;15, 2005.


<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">INTROGEN THERAPEUTICS, INC.<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ DAVID G. NANCE
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">David G. Nance&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">Chief Executive Officer&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>


<P align="center" style="font-size: 10pt">II-4</DIV>

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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<!-- link1 "POWER OF ATTORNEY" -->
<DIV align="left"><A NAME="003"></A></DIV>

<P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>




<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
and appoints David G. Nance and James W. Albrecht, Jr., and each of them, his attorneys-in-fact,
each with the power of substitution, for him and in his name, place and stead, in any and all
capacities, to sign any and all amendments to this Registration Statement, and to file the same,
with all exhibits thereto and all other documents in connection therewith, with the Securities and
Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power
and authority to do and perform each and every act and thing requisite and necessary to be done in
and about the premises, as fully to all intents and purposes as he might or could do in person,
hereby ratifying and confirming all that such attorneys-in-fact and agents or any of them, or his
or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, AS AMENDED, THIS REGISTRATION
STATEMENT ON FORM S-8 HAS BEEN SIGNED BY THE FOLLOWING PERSONS IN THE CAPACITIES AND ON THE DATES
INDICATED.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="38%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="30%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="30%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
<TR>
    <TD>&nbsp;</TD>
</TR>
    <TD align="center" nowrap valign="top"><DIV style="margin-left:15px; text-indent:-15px">/s/ DAVID G. NANCE
<HR size="1" noshade color="#000000">
David G. Nance</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Chief Executive Officer and President
(Principal Executive Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ JAMES W. ALBRECHT, JR.
<HR size="1" noshade color="#000000">
James W. Albrecht, Jr.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Chief Financial Officer
(Principal Financial and Accounting Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ JOHN N. KAPOOR, PH.D.
<HR size="1" noshade color="#000000">
John N. Kapoor, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Chairman of the Board and Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ WILLIAM H. CUNNINGHAM, PH.D.
<HR size="1" noshade color="#000000">
William H. Cunningham, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ S. MALCOLM GILLIS, PH.D.
<HR size="1" noshade color="#000000">
S. Malcolm Gillis, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ PETER BARTON HUTT
<HR size="1" noshade color="#000000">
Peter Barton Hutt</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ CHARLES E. LONG
<HR size="1" noshade color="#000000">
Charles E. Long</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt">II-5</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">



<P align="center" style="font-size: 10pt">INTROGEN THERAPEUTICS, INC.



<P align="center" style="font-size: 10pt">REGISTRATION STATEMENT ON FORM S-8

<!-- link1 "INDEX TO EXHIBITS" -->
<DIV align="left"><A NAME="004"></A></DIV>

<P align="center" style="font-size: 10pt">INDEX TO EXHIBITS


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="6%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="90%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>No.</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Description</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="right" valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="bottom">Opinion of counsel as to legality of securities
being registered.</TD>
</TR>
<TR valign="bottom">
    <TD align="right" valign="top"><DIV style="margin-left:0px; text-indent:-0px">(1) 10.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="bottom">2000 Stock Option Plan.</TD>
</TR>
<TR valign="bottom">
    <TD align="right" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="bottom">Consent of Independent
Registered Public Accounting Firm.</TD>
</TR>
<TR valign="bottom">
    <TD align="right" valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="bottom">Consent of counsel (contained in Exhibit&nbsp;5.1).</TD>
</TR>
<TR valign="bottom">
    <TD align="right" valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="bottom">Power of Attorney (see page II-5).</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<P>
<HR size="1" width="18%" align="left" noshade color="#000000">

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="1%" nowrap align="left">(1)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Incorporated by reference to Exhibit&nbsp;10.3 filed with Registrant&#146;s Registration Statement on
Form S-1 (File No.&nbsp;333-30582), as amended.</TD>
</TR>

</TABLE>




<P align="center" style="font-size: 10pt">II-6</DIV>

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sv8
Table of Contents
As filed with the Securities and Exchange Commission on March 15, 2005
Registration No. 333-_____
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
INTROGEN THERAPEUTICS, INC.
(Exact name of Registrant as specified in its charter)
Delaware
(State or other jurisdiction of
incorporation or organization)
74-2704230
(I.R.S. Employer Identification Number)
301 Congress Avenue, Suite 1850
Austin, Texas 78701
(512) 708-9310
(Address, including zip code, and telephone number, including area code, of
Registrant's principal executive offices)
2000 STOCK OPTION PLAN
(Full title of the plan)
David G. Nance
Chief Executive Officer
INTROGEN THERAPEUTICS, INC.
301 Congress Avenue, Suite 1850
Austin, Texas 78701
(512) 708-9310
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copy to:
Christopher J. Ozburn, Esq.
Wilson Sonsini Goodrich & Rosati
Professional Corporation
8911 Capital of Texas Highway N.
Westech 360, Suite 3350
Austin, TX 78759-7247
CALCULATION OF REGISTRATION FEE
Proposed
Proposed
Amount
Maximum
Maximum
Amount of
of Shares to be
Offering
Aggregate
Registration
Title of Securities to be Registered
Registered (1)
Price Per Share (2)
Offering Price
Fee
2000 Stock Option Plan Common
Stock, $0.001 par value (options
available for future grant)
1,531,140
$
6.96
$
10,656,734.40
$
1,254.30
Table of Contents
(1)
This Registration Statement shall also cover any additional shares of Common Stock which
become issuable under the 2000 Stock Option Plan by reason of any stock dividend, stock split,
recapitalization or any other similar transaction effected without the receipt of
consideration that results in an increase in the number of the Registrant's outstanding shares
of Common Stock.
(2)
The proposed maximum offering price per share has been estimated in accordance with Rule
457(c) under the Securities Act of 1933, as amended (the "Securities Act") as to the 1,531,140
additional shares of Common Stock authorized for issuance pursuant to the 2000 Stock Option
Plan, solely for the purpose of calculating the registration fee. No options have been granted
with respect to such shares. The computation is based upon the average of the high and low
price of the Common Stock as reported on the Nasdaq National Market on March 9, 2005, because
the price at which the options to be granted in the future may be exercised is not currently
determinable.
TABLE OF CONTENTS
PART II
Item 8. Exhibits.
SIGNATURES
POWER OF ATTORNEY
INDEX TO EXHIBITS
Opinion of Counsel
Consent of Independent Registered Public Accounting Firm
Table of Contents
INTROGEN THERAPEUTICS, INC.
REGISTRATION STATEMENT ON FORM S-8
STATEMENT UNDER GENERAL INSTRUCTION E — REGISTRATION OF ADDITIONAL SECURITIES
This Registration Statement on Form S-8 is being filed for the purpose of registering an
additional 1,531,140 shares of the Registrant's Common Stock to be issued pursuant to the
Registrant's 2000 Stock Option Plan (the "Plan"). The contents of (i) the Registrant's Form S-8
Registration Statement filed with the Securities and Exchange Commission on March 5, 2004
(Commission File No. 333-113299) relating to the Plan, (ii) the Registrant's Form S-8 Registration
Statement filed with the Securities and Exchange Commission on April 23, 2003 (Commission File No.
333-104697) relating to the Plan, (iii) the Registrant's Form S-8 Registration Statement filed with
the Securities and Exchange Commission on February 4, 2002 (Commission File No. 333-82122) relating
to the Plan, and (iv) the Registrant's Form S-8 Registration Statement filed with the Securities
and Exchange Commission on April 10, 2001 (Commission File No. 333-58648) relating to the Plan
(collectively, the "Filed Form S-8's"), including periodic filings updating or amending the
contents of the Filed Form S-8's, are incorporated by reference into this Registration Statement
pursuant to General Instruction E of Form S-8.
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
Item 8. Exhibits.
The Exhibits listed on the accompanying Index to Exhibits are filed as part hereof, or
incorporated by reference into, this Registration Statement. (See Index to Exhibits below)
II-3
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant,
Introgen Therapeutics, Inc., certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be
signed on its behalf by the undersigned, thereunto duly authorized, in the City of Austin, State of
Texas, on March 15, 2005.
INTROGEN THERAPEUTICS, INC.
By:
/s/ DAVID G. NANCE
David G. Nance
Chief Executive Officer
II-4
Table of Contents
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes
and appoints David G. Nance and James W. Albrecht, Jr., and each of them, his attorneys-in-fact,
each with the power of substitution, for him and in his name, place and stead, in any and all
capacities, to sign any and all amendments to this Registration Statement, and to file the same,
with all exhibits thereto and all other documents in connection therewith, with the Securities and
Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power
and authority to do and perform each and every act and thing requisite and necessary to be done in
and about the premises, as fully to all intents and purposes as he might or could do in person,
hereby ratifying and confirming all that such attorneys-in-fact and agents or any of them, or his
or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, AS AMENDED, THIS REGISTRATION
STATEMENT ON FORM S-8 HAS BEEN SIGNED BY THE FOLLOWING PERSONS IN THE CAPACITIES AND ON THE DATES
INDICATED.
Signature
Title
Date
/s/ DAVID G. NANCE
David G. Nance
Chief Executive Officer and President
(Principal Executive Officer)
March 15, 2005
/s/ JAMES W. ALBRECHT, JR.
James W. Albrecht, Jr.
Chief Financial Officer
(Principal Financial and Accounting Officer)
March 15, 2005
/s/ JOHN N. KAPOOR, PH.D.
John N. Kapoor, Ph.D.
Chairman of the Board and Director
March 15, 2005
/s/ WILLIAM H. CUNNINGHAM, PH.D.
William H. Cunningham, Ph.D.
Director
March 15, 2005
/s/ S. MALCOLM GILLIS, PH.D.
S. Malcolm Gillis, Ph.D.
Director
March 15, 2005
/s/ PETER BARTON HUTT
Peter Barton Hutt
Director
March 15, 2005
/s/ CHARLES E. LONG
Charles E. Long
Director
March 15, 2005
II-5
Table of Contents
INTROGEN THERAPEUTICS, INC.
REGISTRATION STATEMENT ON FORM S-8
INDEX TO EXHIBITS
Exhibit
No.
Description
5.1
Opinion of counsel as to legality of securities
being registered.
(1) 10.1
2000 Stock Option Plan.
23.1
Consent of Independent
Registered Public Accounting Firm.
23.3
Consent of counsel (contained in Exhibit 5.1).
24.1
Power of Attorney (see page II-5).
(1)
Incorporated by reference to Exhibit 10.3 filed with Registrant's Registration Statement on
Form S-1 (File No. 333-30582), as amended.
II-6