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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<P align="center"><FONT size="2">As filed with the Securities and
Exchange Commission on April&nbsp;23, 2003
</FONT>
<DIV align="right"><FONT size="2">Registration No.&nbsp;333-________
</FONT></DIV>

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<P align="center"><FONT size="4"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B>
</FONT>
<DIV align="center"><FONT size="3"><B>Washington, D.C. 20549</B>
</FONT></DIV>
<P align="center"><FONT size="4"><B>FORM S-8<BR>
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</B>
</FONT>
<P align="center"><FONT size="6">INTROGEN THERAPEUTICS, INC.
</FONT>
<DIV align="center"><FONT size="2"><B>(Exact name of Registrant as specified in its charter)</B>
</FONT></DIV>
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    <TD width="45%">&nbsp;</TD>
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    <TD align="center" valign="top"><FONT size="2"><B>Delaware</B><BR>
<B>(State or other jurisdiction of<BR>
incorporation or organization)</B></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
<B>74-2704230</B><BR>
<B>(I.R.S. Employer Identification Number)</B></FONT></TD>
</TR>
</TABLE>
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<P align="center"><FONT size="2"><B>301 Congress Avenue, Suite&nbsp;1850<BR>
Austin, Texas 78701<BR>
(512)&nbsp;708-9310<BR>
(Address, including zip code, and telephone number, including area code, of Registrant&#146;s principal executive offices)</B>
</FONT>
<P align="center"><FONT size="2"><B>2000 STOCK OPTION PLAN<BR>
(Full title of the plans)</B>
</FONT>
<P align="center"><FONT size="2"><B>David G. Nance<BR>
Chief Executive Officer<BR>
INTROGEN THERAPEUTICS, INC.<BR>
301 Congress Avenue, Suite&nbsp;1850<BR>
Austin, Texas 78701<BR>
(512)&nbsp;708-9310<BR>
(Name, address, including zip code, and telephone number, including area code, of agent for service)</B>
</FONT>
<P align="center"><FONT size="2"><I>Copy to:</I><BR>
<B>Christopher J. Ozburn, Esq.<BR>
Wilson Sonsini Goodrich &#038; Rosati<BR>
Professional Corporation<BR>
8911 Capital of Texas Highway N.<BR>
Westech 360, Suite&nbsp;3350<BR>
Austin, Texas 78759-7247</B>
</FONT>
<P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B>
</FONT>
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    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
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    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Maximum</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Maximum</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
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    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>to be</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Title of Securities to be Registered</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registered (1)</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Price Per Share (2)</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Fee</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
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    <TD colspan="3"><HR size="1" noshade></TD>
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<TR valign="bottom">
    <TD valign="top"><FONT size="2">2000 Stock Option Plan Common
Stock, $0.001 par value (options
available for future grant)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">
1,074,268</FONT></TD>
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right" valign="top"><FONT size="2">$</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">2.35</FONT></TD>
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right" valign="top"><FONT size="2">$</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">2,524,529.80</FONT></TD>
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right" valign="top"><FONT size="2">$</FONT></TD>
    <TD align="right" valign="top"><FONT size="2">204.24</FONT></TD>
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>
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<P>
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    <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">This Registration Statement shall also cover any additional shares of Common
Stock which become issuable under the 2000 Stock Option Plan by reason of any
stock dividend, stock split, recapitalization or any other similar
transaction effected without the receipt of consideration that results in an
increase in the number of the Registrant&#146;s outstanding shares of Common
Stock.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">The proposed maximum offering price per share has been estimated in
accordance with Rule&nbsp;457(c) under the Securities Act of 1933, as amended
(the &#147;Securities Act&#148;) as to the 1,074,268 shares of Common Stock
authorized for issuance pursuant to the 2000 Stock Option Plan, solely for
the purpose of calculating the registration fee. No options have been
granted with respect to such shares. The computation is based upon the
average of the high and low price of the Common Stock as reported on the
Nasdaq National Market on April&nbsp;16, 2003, because the price at which the
options to be granted in the future may be exercised is not currently
determinable.</FONT></TD>
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<P align="center"><FONT size="2">&nbsp;</FONT>
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<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD colspan="9"><A HREF="#000">PART II</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;8. Exhibits.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#002">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">POWER OF ATTORNEY</A></TD></TR>
<TR><TD colspan="9"><A HREF="#004">INDEX TO EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="d05025exv5w1.htm">Ex-5.1 Opinion and Consent of Counsel</A></TD></TR>
<TR><TD colspan="9"><A HREF="d05025exv23w1.htm">EX-23.1 Consent of Ernst & Young LLP</A></TD></TR>
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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>






<P align="center"><FONT size="2">INTROGEN THERAPEUTICS, INC.<BR>
REGISTRATION STATEMENT ON FORM S-8
</FONT>
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<DIV align="left"><A NAME="000"></A></DIV>
<P align="center"><FONT size="2">PART II
</FONT>
<P align="center"><FONT size="2">INFORMATION REQUIRED IN REGISTRATION STATEMENT
</FONT>
<P align="left"><FONT size="2"><U>Explanatory Note</U>
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement on Form&nbsp;S-8 is being filed for the purpose of
registering an additional 1,074,268 shares of the Registrant&#146;s Common Stock to
be issued pursuant to the Registrant&#146;s 2000 Stock Option Plan (the &#147;Plan&#148;).
The contents of (i)&nbsp;the Registrant&#146;s Form&nbsp;S-8 Registration Statement filed with
the Securities and Exchange Commission on February&nbsp;4, 2002 (Commission File No.
333-82122) relating to the Plan and (ii)&nbsp;the Registrant&#146;s Form&nbsp;S-8 Registration
Statement filed with the Securities and Exchange Commission on April&nbsp;10, 2001
(Commission File No.&nbsp;333-58648) relating to the Plan are incorporated herein by
reference.
</FONT>
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<DIV align="left"><A NAME="001"></A></DIV>
<P align="left"><FONT size="2">Item&nbsp;8. <U>Exhibits.</U>
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Exhibits listed on the accompanying Index to Exhibits are filed as
part hereof, or incorporated by reference into, this Registration Statement.
(See Index to Exhibits below)
</FONT>
<P align="center"><FONT size="2">II-2</FONT>
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<DIV align="left"><A NAME="002"></A></DIV>
<P align="center"><FONT size="2"><B>SIGNATURES</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant, Introgen Therapeutics, Inc., certifies that it has reasonable
grounds to believe that it meets all of the requirements for filing on Form&nbsp;S-8
and has duly caused this Registration Statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of Austin, State of
Texas, on April&nbsp;23, 2003.
</FONT>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top" colspan="3"><FONT size="2">INTROGEN THERAPEUTICS, INC.</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
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    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
By:
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">/s/ David G. Nance<BR>
</FONT><HR size="1" noshade><FONT size="2">
David G. Nance<BR>
Chief Executive Officer</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">II-3</FONT>
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<!-- link1 "POWER OF ATTORNEY" -->
<DIV align="left"><A NAME="003"></A></DIV>
<P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints David G. Nance and James W. Albrecht,
Jr., and each of them, his attorneys-in-fact, each with the power of
substitution, for him and in his name, place and stead, in any and all
capacities, to sign any and all amendments to this Registration Statement, and
to file the same, with all exhibits thereto and all other documents in
connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that such attorneys-in-fact and agents or any of them, or his or their
substitute or substitutes, may lawfully do or cause to be done by virtue
hereof.
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, AS AMENDED,
THIS REGISTRATION STATEMENT ON FORM S-8 HAS BEEN SIGNED BY THE FOLLOWING
PERSONS IN THE CAPACITIES AND ON THE DATES INDICATED.
</FONT>
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    <TD width="12%">&nbsp;</TD>
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    <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
</TR>
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    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
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    <TD nowrap align="center"><HR size="1" noshade></TD>
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<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ David G. Nance<BR>
</FONT><HR size="1" noshade><FONT size="2">
David G. Nance</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Chief Executive Officer and President (Principal<BR>
Executive Officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 23, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
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    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ James W. Albrecht, Jr.<BR>
</FONT><HR size="1" noshade><FONT size="2">
James W. Albrecht, Jr.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Chief Financial Officer (Principal Financial and<BR>
Accounting Officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 23, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
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    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ John N. Kapoor, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
John N. Kapoor, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Chairman of the Board and Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 23, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ William H. Cunningham, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
William H. Cunningham, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 23, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
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    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ Charles E. Long<BR>
</FONT><HR size="1" noshade><FONT size="2">
Charles E. Long</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 23, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ Mahendra G. Shah, Ph.D.<BR>
</FONT><HR size="1" noshade><FONT size="2">
Mahendra G. Shah, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 23, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">/s/ Robert L. Moore<BR>
</FONT><HR size="1" noshade><FONT size="2">
Robert L. Moore</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 23, 2003</FONT></TD>
</TR>
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<P align="center"><FONT size="2">II-4</FONT>
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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<P align="center"><FONT size="2">INTROGEN THERAPEUTICS, INC.
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<P align="center"><FONT size="2">REGISTRATION STATEMENT ON FORM S-8
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<P align="center"><FONT size="2">INDEX TO EXHIBITS
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    <TD nowrap align="center"><FONT size="1"><B>Description</B></FONT></TD>
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5.1</FONT></TD>
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    <TD align="left" valign="top"><FONT size="2">Opinion of counsel as to legality of securities being registered.</FONT></TD>
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10.1</FONT></TD>
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    <TD align="left" valign="top"><FONT size="2">2000 Stock Option
Plan.</FONT></TD>
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23.1</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">Consent of Ernst
&#038; Young LLP, independent auditors.</FONT></TD>
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23.2</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">Consent of Arthur
Andersen LLP, independent auditors (omitted pursuant to
Rule 437a promulgated under the Securities Act of 1933, as amended).</FONT></TD>
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23.3</FONT></TD>
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    <TD align="left" valign="top"><FONT size="2">Consent of counsel (contained in Exhibit&nbsp;5.1).</FONT></TD>
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24.1</FONT></TD>
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    <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
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    <TD width="96%"><FONT size="2">Incorporated by reference to Exhibit&nbsp;10.3 filed with Registrant&#146;s
Registration Statement on Form&nbsp;S-1 (File No.&nbsp;333-30582), as amended.</FONT></TD>
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<P align="center"><FONT size="2">II-5</FONT>
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sv8
Table of Contents
As filed with the Securities and
Exchange Commission on April 23, 2003
Registration No. 333-________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
INTROGEN THERAPEUTICS, INC.
(Exact name of Registrant as specified in its charter)
Delaware
(State or other jurisdiction of
incorporation or organization)
74-2704230
(I.R.S. Employer Identification Number)
301 Congress Avenue, Suite 1850
Austin, Texas 78701
(512) 708-9310
(Address, including zip code, and telephone number, including area code, of Registrant's principal executive offices)
2000 STOCK OPTION PLAN
(Full title of the plans)
David G. Nance
Chief Executive Officer
INTROGEN THERAPEUTICS, INC.
301 Congress Avenue, Suite 1850
Austin, Texas 78701
(512) 708-9310
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copy to:
Christopher J. Ozburn, Esq.
Wilson Sonsini Goodrich & Rosati
Professional Corporation
8911 Capital of Texas Highway N.
Westech 360, Suite 3350
Austin, Texas 78759-7247
CALCULATION OF REGISTRATION FEE
Proposed
Proposed
Amount
Maximum
Maximum
Amount of
to be
Offering
Aggregate
Registration
Title of Securities to be Registered
Registered (1)
Price Per Share (2)
Offering Price
Fee
2000 Stock Option Plan Common
Stock, $0.001 par value (options
available for future grant)
1,074,268
$
2.35
$
2,524,529.80
$
204.24
(1)
This Registration Statement shall also cover any additional shares of Common
Stock which become issuable under the 2000 Stock Option Plan by reason of any
stock dividend, stock split, recapitalization or any other similar
transaction effected without the receipt of consideration that results in an
increase in the number of the Registrant's outstanding shares of Common
Stock.
(2)
The proposed maximum offering price per share has been estimated in
accordance with Rule 457(c) under the Securities Act of 1933, as amended
(the "Securities Act") as to the 1,074,268 shares of Common Stock
authorized for issuance pursuant to the 2000 Stock Option Plan, solely for
the purpose of calculating the registration fee. No options have been
granted with respect to such shares. The computation is based upon the
average of the high and low price of the Common Stock as reported on the
Nasdaq National Market on April 16, 2003, because the price at which the
options to be granted in the future may be exercised is not currently
determinable.
TABLE OF CONTENTS
PART II
Item 8. Exhibits.
SIGNATURES
POWER OF ATTORNEY
INDEX TO EXHIBITS
Ex-5.1 Opinion and Consent of Counsel
EX-23.1 Consent of Ernst & Young LLP
Table of Contents
INTROGEN THERAPEUTICS, INC.
REGISTRATION STATEMENT ON FORM S-8
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
Explanatory Note
This Registration Statement on Form S-8 is being filed for the purpose of
registering an additional 1,074,268 shares of the Registrant's Common Stock to
be issued pursuant to the Registrant's 2000 Stock Option Plan (the "Plan").
The contents of (i) the Registrant's Form S-8 Registration Statement filed with
the Securities and Exchange Commission on February 4, 2002 (Commission File No.
333-82122) relating to the Plan and (ii) the Registrant's Form S-8 Registration
Statement filed with the Securities and Exchange Commission on April 10, 2001
(Commission File No. 333-58648) relating to the Plan are incorporated herein by
reference.
Item 8.
Exhibits.
The Exhibits listed on the accompanying Index to Exhibits are filed as
part hereof, or incorporated by reference into, this Registration Statement.
(See Index to Exhibits below)
II-2
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant, Introgen Therapeutics, Inc., certifies that it has reasonable
grounds to believe that it meets all of the requirements for filing on Form S-8
and has duly caused this Registration Statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of Austin, State of
Texas, on April 23, 2003.
INTROGEN THERAPEUTICS, INC.
By:
/s/ David G. Nance
David G. Nance
Chief Executive Officer
II-3
Table of Contents
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints David G. Nance and James W. Albrecht,
Jr., and each of them, his attorneys-in-fact, each with the power of
substitution, for him and in his name, place and stead, in any and all
capacities, to sign any and all amendments to this Registration Statement, and
to file the same, with all exhibits thereto and all other documents in
connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that such attorneys-in-fact and agents or any of them, or his or their
substitute or substitutes, may lawfully do or cause to be done by virtue
hereof.
PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, AS AMENDED,
THIS REGISTRATION STATEMENT ON FORM S-8 HAS BEEN SIGNED BY THE FOLLOWING
PERSONS IN THE CAPACITIES AND ON THE DATES INDICATED.
Signature
Title
Date
/s/ David G. Nance
David G. Nance
Chief Executive Officer and President (Principal
Executive Officer)
April 23, 2003
/s/ James W. Albrecht, Jr.
James W. Albrecht, Jr.
Chief Financial Officer (Principal Financial and
Accounting Officer)
April 23, 2003
/s/ John N. Kapoor, Ph.D.
John N. Kapoor, Ph.D.
Chairman of the Board and Director
April 23, 2003
/s/ William H. Cunningham, Ph.D.
William H. Cunningham, Ph.D.
Director
April 23, 2003
/s/ Charles E. Long
Charles E. Long
Director
April 23, 2003
/s/ Mahendra G. Shah, Ph.D.
Mahendra G. Shah, Ph.D.
Director
April 23, 2003
/s/ Robert L. Moore
Robert L. Moore
Director
April 23, 2003
II-4
Table of Contents
INTROGEN THERAPEUTICS, INC.
REGISTRATION STATEMENT ON FORM S-8
INDEX TO EXHIBITS
Exhibit No.
Description
5.1
Opinion of counsel as to legality of securities being registered.
(1)
10.1
2000 Stock Option
Plan.
23.1
Consent of Ernst
& Young LLP, independent auditors.
23.2
Consent of Arthur
Andersen LLP, independent auditors (omitted pursuant to
Rule 437a promulgated under the Securities Act of 1933, as amended).
23.3
Consent of counsel (contained in Exhibit 5.1).
24.1
Power of Attorney
(see page II-4).
(1)
Incorporated by reference to Exhibit 10.3 filed with Registrant's
Registration Statement on Form S-1 (File No. 333-30582), as amended.
II-5