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<DIV style="font-family: 'Times New Roman',Times,serif">


<P align="center" style="font-size: 10pt">As filed with the Securities and Exchange Commission on August&nbsp;6, 2004<BR>
Registration No.&nbsp;333-&#95;&#95;&#95;

<P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>

<DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
</DIV>

<P align="center" style="font-size: 18pt"><B>FORM S-8</B>


<P align="center" style="font-size: 10pt">REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933

<P align="center" style="font-size: 24pt"><B>ADVANCIS PHARMACEUTICAL CORPORATION</B>


<DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="95%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>
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<TR valign="bottom">
    <TD align="center" valign="top"><B>Delaware</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>52-2208264</B></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">(State or other jurisdiction of
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(I.R.S. Employer Identification No.)</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">Incorporation or organization)</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><B>20425 Seneca Meadows Parkway</B></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><B>Germantown, Maryland 20876</B></TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><B>(301)&nbsp;944-6600</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>20876</B></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top">(Address of principal executive offices)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(Zip Code)</TD>
</TR>

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</TABLE>
</DIV>



<P align="center" style="font-size: 10pt"><B>AMENDED AND RESTATED ADVANCIS PHARMACEUTICAL CORPORATION<BR>
STOCK INCENTIVE PLAN</B><BR>
(Full title of plan)

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="95%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>
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<TR valign="bottom">
    <TD align="center" valign="top">(Name, address and telephone<BR>
number of agent for service)<BR>
<B>Edward M. Rudnic, Ph.D.<BR>
President and Chief Executive Officer<BR>
Advancis Pharmaceutical Corporation<BR>
20425 Seneca Meadows Parkway<BR>
Germantown, Maryland 20876<BR>
(301)&nbsp;944-6600</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(Copy to)<BR>
<B>R.W. Smith, Jr., Esq.<BR>
Howard S. Schwartz, Esq.<BR>
Piper Rudnick LLP<BR>
6225 Smith Avenue<BR>
Baltimore, Maryland 21209<BR>
(410)&nbsp;580-3000</B></TD>
</TR>

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</TABLE>
</DIV>



<P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="39%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="6%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="6%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="4%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
</TR>

<TR style="font-size: 1px">
    <TD colspan="17" valign="top" align="left"><HR size="4" noshade>&nbsp;</TD>
</TR>

<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Proposed</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Proposed</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Amount</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Amount of</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>to be</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Offering</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Aggregate</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Registration</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Title of Securities to be Registered</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Registered</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Price Per Unit (2)</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Offering Price</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Fee</B></TD>
</TR>
<TR style="font-size: 1px">
    <TD colspan="17" valign="top" align="left"><HR size="1" noshade>&nbsp;</TD>
</TR>

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<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Common Stock, $.01 par value
Stock Incentive Plan
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">1,250,000 </TD>
    <TD nowrap valign="top">(1)</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" valign="top">$</TD>
    <TD align="right" valign="top">8.07</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" valign="top">$</TD>
    <TD align="right" valign="top">10,087,500</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" valign="top">$</TD>
    <TD align="right" valign="top">1,278.09</TD>
    <TD nowrap valign="top">&nbsp;</TD>
</TR>

<TR style="font-size: 1px">
    <TD colspan="17" valign="top" align="left"><HR size="1" noshade>&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">TOTAL
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" valign="top">&nbsp;</TD>
    <TD align="right" valign="top">1,250,000</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" valign="top">$</TD>
    <TD align="right" valign="top">8.07</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" valign="top">$</TD>
    <TD align="right" valign="top">10,087,500</TD>
    <TD nowrap valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" valign="top">$</TD>
    <TD align="right" valign="top">1,278.09</TD>
    <TD nowrap valign="top">&nbsp;</TD>
</TR>
<TR style="font-size: 1px">
    <TD colspan="17" valign="top" align="left"><HR size="4" noshade>&nbsp;</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>


<P align="left" style="font-size: 10pt">(1)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; An aggregate of 6,348,182 shares of Common Stock may be offered or
issued pursuant to the Amended and Restated Advancis Pharmaceutical Corporation
Stock Incentive Plan, 4,567,679 of which were previously registered on Form S-8
filed on October&nbsp;15, 2003 (File No.&nbsp;333-109728), and 1,250,000 of which are
registered on this Form S-8.


<P align="left" style="font-size: 10pt">(2)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Estimated solely for purposes of calculating the registration fee pursuant
to Rule 457(c) and (h). The proposed maximum offering price per share,
proposed maximum aggregate offering price and the amount of the registration
fee are based on the average of the high and low prices of the Registrant&#146;s
Common Stock as reported on the Nasdaq National Market on August&nbsp;4, 2004 (i.e.,
$8.07). Pursuant to General Instruction E of Form S-8, the registration fee is
calculated with respect to the additional securities registered on this Form
S-8 only.



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">




<P align="center" style="font-size: 10pt"><B>INCORPORATION BY REFERENCE</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with General Instruction E to Form S-8, the contents of the
Registration Statement filed by Advancis Pharmaceutical Corporation (the
&#147;Registrant&#148;) with the Securities and Exchange Commission (the &#147;Commission&#148;) on
October&nbsp;15, 2003 (File No.&nbsp;333-109728), with respect to securities offered
pursuant to the Amended and Restated Advancis Pharmaceutical Corporation Stock
Incentive Plan are hereby incorporated by reference.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Registrant pursuant to Sections&nbsp;13(a), 13(c),
14 or 15(d) of the Securities Exchange Act of 1934, as amended, subsequent to
the date of this Registration Statement and prior to the filing of a
post-effective amendment that indicates that all securities offered have been
sold or that deregisters all securities remaining unsold, shall be deemed to be
incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing of such documents.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any statement contained in a document incorporated or deemed to be
incorporated by reference herein shall be deemed to be modified or superseded
for purposes of this Registration Statement to the extent that a statement
contained herein or in any other subsequently filed document which also is or
is deemed to be incorporated by reference herein modifies or supersedes such
statement. Any such statement so modified or superseded shall not be deemed,
except as so modified or superseded, to constitute a part of this Registration
Statement.


<P align="center" style="font-size: 10pt"><B>EXHIBITS</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="9%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="86%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>EXHIBIT</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid gray"><B>NUMBER</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left" style="border-bottom: 1px solid gray"><B>DESCRIPTION</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Fifth Restated Certificate of Incorporation of the Registrant, as
amended (incorporated by reference from Exhibit&nbsp;3.1 of the
Registrant&#146;s Registration Statement on Form&nbsp;S-1) (File No.
333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amendment to Certificate of Incorporation of the Registrant
(incorporated by reference from Exhibit&nbsp;3.2 of Amendment No.&nbsp;1 to
the Registrant&#146;s Registration Statement on Form&nbsp;S-1) (File No.
333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Form of Certificate of Incorporation of the Registrant to be in
effect after the closing of the offering made pursuant to the
Registration Statement on Form&nbsp;S-1 (incorporated by reference from
Exhibit&nbsp;3.2 of the Registrant&#146;s Registration Statement on Form
S-1) (File No.&nbsp;333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amended and Restated Bylaws of the Registrant, as amended
(incorporated by reference from Exhibit&nbsp;3.3 of the Registrant&#146;s
Registration Statement on Form&nbsp;S-1) (File No.&nbsp;333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Form of Bylaws of the Registrant to be in effect after the closing
of the offering made pursuant to the Registration Statement on
Form&nbsp;S-1 (incorporated by reference from Exhibit&nbsp;3.4 of the
Registrant&#146;s Registration Statement on Form&nbsp;S-1) (File No.
333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.6
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Stock Certificate for shares of Common Stock of the
Registrant (incorporated by reference from Exhibit&nbsp;4.1 of the
Registrant&#146;s Registration Statement on Form&nbsp;S-1) (File No.
333-107599)</TD>
</TR>

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</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="9%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="86%">&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.7
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amended and Restated Advancis Pharmaceutical Corporation Stock
Incentive Plan (incorporated by reference from Annex B to the
Registrant&#146;s Definitive Proxy Statement on Schedule&nbsp;DEF14A) (File
No.&nbsp;000-50414)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Piper Rudnick LLP, counsel for the Registrant,
regarding the legal validity of the shares of Common Stock being
registered on this Registration Statement (filed herewith)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Counsel (contained in Exhibit&nbsp;5.1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Independent Registered Public Accounting Firm (filed
herewith)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (included on Signature Page)</TD>
</TR>

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</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Germantown, State of Maryland, on the 6th day
of August, 2004.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="55%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="18%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="61%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" valign="top" align="left">ADVANCIS PHARMACEUTICAL CORPORATION</TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">/s/ Edward M. Rudnic</TD>
</TR>

<TR style="font-size: 1px">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><HR size="1" noshade>&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Edward M. Rudnic, Ph.D.<br>
President and Chief Executive Officer</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">


<P align="center" style="font-size: 10pt"><B>POWERS OF ATTORNEY</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Edward
M. Rudnic, Ph.D. and Steven A. Shallcross as his true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution,
for such person and in his name, place and stead, in any and all capacities, to
sign any or all further amendments (including post-effective amendments) to
this Registration Statement, and to file the same, with all exhibits thereto,
and other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorney-in-fact and agent, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that said attorney-in-fact and agent, or his substitute or substitutes, may
lawfully do or cause to be done by virtue hereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Form S-8
Registration Statement has been signed by the following persons in the
capacities and on the date indicated.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="35%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="21%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid gray"><B>Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid gray"><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid gray"><B>Date</B></TD>
</TR>
<TR>
    <TD>&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="left" nowrap valign="top">/s/ Edward M. Rudnic, Ph.D.<BR>
<HR size="1" noshade>
Edward M. Rudnic, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Chairman of the Board, President and Chief Executive
Officer (Principal Executive Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">August 6, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Steven A. Shallcross<BR>
<HR size="1" noshade>
Steven A. Shallcross</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Senior Vice President, Chief
Financial Officer and Treasurer
(Principal Financial and
Accounting Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">August 6, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ James H. Cavanaugh, Ph.D.<BR>
<HR size="1" noshade>
James H. Cavanaugh, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">August 6, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Elizabeth Czerepak<BR>
<HR size="1" noshade>
Elizabeth Czerepak</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">August 6, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ R. Gordon Douglas, M.D.<BR>
<HR size="1" noshade>
R. Gordon Douglas, M.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">August 6, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Richard W. Dugan<BR>
<HR size="1" noshade>
Richard W. Dugan</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">August 6, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Wayne T. Hockmeyer, Ph.D.<BR>
<HR size="1" noshade>
Wayne T. Hockmeyer, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">August 6, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Harold R. Werner<BR>
<HR size="1" noshade>
Harold R. Werner</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">August 6, 2004</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<P align="center" style="font-size: 10pt"><B>EXHIBIT INDEX</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="9%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="86%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>EXHIBIT</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid gray"><B>NUMBER</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left" style="border-bottom: 1px solid gray"><B>DESCRIPTION</B></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Fifth Restated Certificate of Incorporation of the Registrant, as
amended (incorporated by reference from Exhibit&nbsp;3.1 of the
Registrant&#146;s Registration Statement on Form&nbsp;S-1) (File No.
333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amendment to Certificate of Incorporation of the Registrant
(incorporated by reference from Exhibit&nbsp;3.2 of Amendment No.&nbsp;1 to
the Registrant&#146;s Registration Statement on Form&nbsp;S-1) (File No.
333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Form of Certificate of Incorporation of the Registrant to be in
effect after the closing of the offering made pursuant to the
Registration Statement on Form&nbsp;S-1 (incorporated by reference from
Exhibit&nbsp;3.2 of the Registrant&#146;s Registration Statement on Form
S-1) (File No.&nbsp;333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amended and Restated Bylaws of the Registrant, as amended
(incorporated by reference from Exhibit&nbsp;3.3 of the Registrant&#146;s
Registration Statement on Form&nbsp;S-1) (File No.&nbsp;333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.5
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Form of Bylaws of the Registrant to be in effect after the closing
of the offering made pursuant to the Registration Statement on
Form&nbsp;S-1 (incorporated by reference from Exhibit&nbsp;3.4 of the
Registrant&#146;s Registration Statement on Form&nbsp;S-1) (File No.
333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.6
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen Stock Certificate for shares of Common Stock of the
Registrant (incorporated by reference from Exhibit&nbsp;4.1 of the
Registrant&#146;s Registration Statement on Form&nbsp;S-1) (File No.
333-107599)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.7
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amended and Restated Advancis Pharmaceutical Corporation Stock
Incentive Plan (incorporated by reference from Annex B to the
Registrant&#146;s Definitive Proxy Statement on Schedule&nbsp;DEF14A) (File
No.&nbsp;000-50414)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Piper Rudnick LLP, counsel for the Registrant,
regarding the legal validity of the shares of Common Stock being
registered on this Registration Statement (filed herewith)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Counsel (contained in Exhibit&nbsp;5.1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Independent Registered Public Accounting Firm (filed
herewith)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney (included on Signature Page)</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

</BODY>
</HTML>
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{"company-data": {"conformed-name": "ADVANCIS PHARMACEUTICAL CORP", "cik": "0001161924", "assigned-sic": "2834", "irs-number": "522208264"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-118003", "film-number": "04958371"}, "business-address": {"street1": "20425 SENECA MEADOWS PARKWAY", "city": "GERMANTOWN", "state": "MD", "zip": "20878", "phone": "(301) 944-6600"}}
sv8
As filed with the Securities and Exchange Commission on August 6, 2004
Registration No. 333-___
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
ADVANCIS PHARMACEUTICAL CORPORATION
(Exact name of registrant as specified in its charter)
Delaware
52-2208264
(State or other jurisdiction of
(I.R.S. Employer Identification No.)
Incorporation or organization)
20425 Seneca Meadows Parkway
Germantown, Maryland 20876
(301) 944-6600
20876
(Address of principal executive offices)
(Zip Code)
AMENDED AND RESTATED ADVANCIS PHARMACEUTICAL CORPORATION
STOCK INCENTIVE PLAN
(Full title of plan)
(Name, address and telephone
number of agent for service)
Edward M. Rudnic, Ph.D.
President and Chief Executive Officer
Advancis Pharmaceutical Corporation
20425 Seneca Meadows Parkway
Germantown, Maryland 20876
(301) 944-6600
(Copy to)
R.W. Smith, Jr., Esq.
Howard S. Schwartz, Esq.
Piper Rudnick LLP
6225 Smith Avenue
Baltimore, Maryland 21209
(410) 580-3000
CALCULATION OF REGISTRATION FEE
Proposed
Proposed
Amount
Maximum
Maximum
Amount of
to be
Offering
Aggregate
Registration
Title of Securities to be Registered
Registered
Price Per Unit (2)
Offering Price
Fee
Common Stock, $.01 par value
Stock Incentive Plan
1,250,000
(1)
$
8.07
$
10,087,500
$
1,278.09
TOTAL
1,250,000
$
8.07
$
10,087,500
$
1,278.09
(1)      An aggregate of 6,348,182 shares of Common Stock may be offered or
issued pursuant to the Amended and Restated Advancis Pharmaceutical Corporation
Stock Incentive Plan, 4,567,679 of which were previously registered on Form S-8
filed on October 15, 2003 (File No. 333-109728), and 1,250,000 of which are
registered on this Form S-8.
(2)      Estimated solely for purposes of calculating the registration fee pursuant
to Rule 457(c) and (h). The proposed maximum offering price per share,
proposed maximum aggregate offering price and the amount of the registration
fee are based on the average of the high and low prices of the Registrant's
Common Stock as reported on the Nasdaq National Market on August 4, 2004 (i.e.,
$8.07). Pursuant to General Instruction E of Form S-8, the registration fee is
calculated with respect to the additional securities registered on this Form
S-8 only.
INCORPORATION BY REFERENCE
In accordance with General Instruction E to Form S-8, the contents of the
Registration Statement filed by Advancis Pharmaceutical Corporation (the
"Registrant") with the Securities and Exchange Commission (the "Commission") on
October 15, 2003 (File No. 333-109728), with respect to securities offered
pursuant to the Amended and Restated Advancis Pharmaceutical Corporation Stock
Incentive Plan are hereby incorporated by reference.
All documents filed by the Registrant pursuant to Sections 13(a), 13(c),
14 or 15(d) of the Securities Exchange Act of 1934, as amended, subsequent to
the date of this Registration Statement and prior to the filing of a
post-effective amendment that indicates that all securities offered have been
sold or that deregisters all securities remaining unsold, shall be deemed to be
incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing of such documents.
Any statement contained in a document incorporated or deemed to be
incorporated by reference herein shall be deemed to be modified or superseded
for purposes of this Registration Statement to the extent that a statement
contained herein or in any other subsequently filed document which also is or
is deemed to be incorporated by reference herein modifies or supersedes such
statement. Any such statement so modified or superseded shall not be deemed,
except as so modified or superseded, to constitute a part of this Registration
Statement.
EXHIBITS
EXHIBIT
NUMBER
DESCRIPTION
4.1
Fifth Restated Certificate of Incorporation of the Registrant, as
amended (incorporated by reference from Exhibit 3.1 of the
Registrant's Registration Statement on Form S-1) (File No.
333-107599)
4.2
Amendment to Certificate of Incorporation of the Registrant
(incorporated by reference from Exhibit 3.2 of Amendment No. 1 to
the Registrant's Registration Statement on Form S-1) (File No.
333-107599)
4.3
Form of Certificate of Incorporation of the Registrant to be in
effect after the closing of the offering made pursuant to the
Registration Statement on Form S-1 (incorporated by reference from
Exhibit 3.2 of the Registrant's Registration Statement on Form
S-1) (File No. 333-107599)
4.4
Amended and Restated Bylaws of the Registrant, as amended
(incorporated by reference from Exhibit 3.3 of the Registrant's
Registration Statement on Form S-1) (File No. 333-107599)
4.5
Form of Bylaws of the Registrant to be in effect after the closing
of the offering made pursuant to the Registration Statement on
Form S-1 (incorporated by reference from Exhibit 3.4 of the
Registrant's Registration Statement on Form S-1) (File No.
333-107599)
4.6
Specimen Stock Certificate for shares of Common Stock of the
Registrant (incorporated by reference from Exhibit 4.1 of the
Registrant's Registration Statement on Form S-1) (File No.
333-107599)
4.7
Amended and Restated Advancis Pharmaceutical Corporation Stock
Incentive Plan (incorporated by reference from Annex B to the
Registrant's Definitive Proxy Statement on Schedule DEF14A) (File
No. 000-50414)
5.1
Opinion of Piper Rudnick LLP, counsel for the Registrant,
regarding the legal validity of the shares of Common Stock being
registered on this Registration Statement (filed herewith)
23.1
Consent of Counsel (contained in Exhibit 5.1)
23.2
Consent of Independent Registered Public Accounting Firm (filed
herewith)
24.1
Power of Attorney (included on Signature Page)
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Germantown, State of Maryland, on the 6th day
of August, 2004.
ADVANCIS PHARMACEUTICAL CORPORATION
By:
/s/ Edward M. Rudnic
Edward M. Rudnic, Ph.D.
President and Chief Executive Officer
POWERS OF ATTORNEY
Each person whose signature appears below constitutes and appoints Edward
M. Rudnic, Ph.D. and Steven A. Shallcross as his true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution,
for such person and in his name, place and stead, in any and all capacities, to
sign any or all further amendments (including post-effective amendments) to
this Registration Statement, and to file the same, with all exhibits thereto,
and other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorney-in-fact and agent, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that said attorney-in-fact and agent, or his substitute or substitutes, may
lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Form S-8
Registration Statement has been signed by the following persons in the
capacities and on the date indicated.
Signature
Title
Date
/s/ Edward M. Rudnic, Ph.D.
Edward M. Rudnic, Ph.D.
Chairman of the Board, President and Chief Executive
Officer (Principal Executive Officer)
August 6, 2004
/s/ Steven A. Shallcross
Steven A. Shallcross
Senior Vice President, Chief
Financial Officer and Treasurer
(Principal Financial and
Accounting Officer)
August 6, 2004
/s/ James H. Cavanaugh, Ph.D.
James H. Cavanaugh, Ph.D.
Director
August 6, 2004
/s/ Elizabeth Czerepak
Elizabeth Czerepak
Director
August 6, 2004
/s/ R. Gordon Douglas, M.D.
R. Gordon Douglas, M.D.
Director
August 6, 2004
/s/ Richard W. Dugan
Richard W. Dugan
Director
August 6, 2004
/s/ Wayne T. Hockmeyer, Ph.D.
Wayne T. Hockmeyer, Ph.D.
Director
August 6, 2004
/s/ Harold R. Werner
Harold R. Werner
Director
August 6, 2004
EXHIBIT INDEX
EXHIBIT
NUMBER
DESCRIPTION
4.1
Fifth Restated Certificate of Incorporation of the Registrant, as
amended (incorporated by reference from Exhibit 3.1 of the
Registrant's Registration Statement on Form S-1) (File No.
333-107599)
4.2
Amendment to Certificate of Incorporation of the Registrant
(incorporated by reference from Exhibit 3.2 of Amendment No. 1 to
the Registrant's Registration Statement on Form S-1) (File No.
333-107599)
4.3
Form of Certificate of Incorporation of the Registrant to be in
effect after the closing of the offering made pursuant to the
Registration Statement on Form S-1 (incorporated by reference from
Exhibit 3.2 of the Registrant's Registration Statement on Form
S-1) (File No. 333-107599)
4.4
Amended and Restated Bylaws of the Registrant, as amended
(incorporated by reference from Exhibit 3.3 of the Registrant's
Registration Statement on Form S-1) (File No. 333-107599)
4.5
Form of Bylaws of the Registrant to be in effect after the closing
of the offering made pursuant to the Registration Statement on
Form S-1 (incorporated by reference from Exhibit 3.4 of the
Registrant's Registration Statement on Form S-1) (File No.
333-107599)
4.6
Specimen Stock Certificate for shares of Common Stock of the
Registrant (incorporated by reference from Exhibit 4.1 of the
Registrant's Registration Statement on Form S-1) (File No.
333-107599)
4.7
Amended and Restated Advancis Pharmaceutical Corporation Stock
Incentive Plan (incorporated by reference from Annex B to the
Registrant's Definitive Proxy Statement on Schedule DEF14A) (File
No. 000-50414)
5.1
Opinion of Piper Rudnick LLP, counsel for the Registrant,
regarding the legal validity of the shares of Common Stock being
registered on this Registration Statement (filed herewith)
23.1
Consent of Counsel (contained in Exhibit 5.1)
23.2
Consent of Independent Registered Public Accounting Firm (filed
herewith)
24.1
Power of Attorney (included on Signature Page)