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<P align="center"><FONT size="2">SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549<BR>
<u>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u>
</FONT>
<P align="center"><FONT size="2">FORM S-8
</FONT>
<P align="center"><FONT size="2">REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
</FONT>
<P align="center"><FONT size="2">ARQULE, INC.<BR>
(Exact Name of registrant as specified in its charter)
</FONT>
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<TABLE cellspacing="0" border="0" cellpadding="0" width="55%">
<TR valign="bottom">
    <TD width="50%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="45%">&nbsp;</TD>
</TR>
<TR valign="bottom">
      <TD align="center" valign="top"><FONT size="2"><u>Delaware</u></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center" valign="top"><FONT size="2"> <u>58-1959440</u></FONT></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2">(State or other jurisdiction of</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
(I.R.S. Employer</FONT></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2">incorporation or organization)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
Identification No.)</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">19 Presidential Way,<BR>
  <u>Woburn, Massachusetts 01801</u><BR>
(Address, including zip code, of principal executive offices)
</FONT>
<P align="center"><FONT size="2"><u>ArQule, Inc. Amended and Restated 1996 Employee
  Stock Purchase Plan</u><BR>
(Full title of the plan)
</FONT>
<P align="center"><FONT size="2">Dr.&nbsp;Stephen A. Hill<BR>
President and Chief Executive Officer<BR>
ArQule, Inc.<BR>
19 Presidential Way,<BR>
Woburn, Massachusetts 01801<BR>
(781)&nbsp;994-0300
</FONT>
<P align="center"><FONT size="2">(Name, address, including zip code, and telephone number including area code,<BR>
of agent for service)
</FONT>
<P align="center"><FONT size="2">Copy to:<BR>
Richard E. Baltz, Esq.<BR>
Arnold &#038; Porter<BR>
555 12th Street, N.W.
</FONT>
<P align="center"><FONT size="2">Washington, D.C. 20004<BR>
(202)&nbsp;942-5124<BR>
<u>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u>
</FONT>
<P align="center"><FONT size="2">Calculation of Registration Fee
</FONT>
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  <TABLE cellspacing="0" border="0" cellpadding="0" width="65%">
    <TR valign="bottom">
      <TD width="30%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="12%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="19%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="12%">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Proposed maximum</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Proposed maximum</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>Title of securities</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Amount to be</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>offering price per</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>aggregate offering</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>Amount of</B></FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>to be registered</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>registered (1)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>unit (2)(3)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>price (3)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><FONT size="1"><B>registration fee</B></FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><HR size="1" noshade></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><div align="center"><FONT size="2">Common Stock,</FONT></div></TD>
      <TD><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>
      <TD align="left" valign="top"><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>
      <TD><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>
      <TD align="left" valign="top"><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>
      <TD><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>
      <TD align="left" valign="top"><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>
      <TD><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>
      <TD align="left" valign="top"><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><div align="center"><FONT size="2">$.01 par value</FONT></div></TD>
      <TD><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>
      <TD align="left" valign="top"><div align="center"><FONT size="2"> 300,000
          </FONT></div></TD>
      <TD><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>

<TD align="left" valign="top"><div align="center"><FONT size="2">$4.55 </FONT></div></TD>
      <TD><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>

<TD align="left" valign="top"><div align="center"><FONT size="2">$1,365,000
          </FONT></div></TD>
      <TD><div align="center"><FONT size="2">&nbsp;</FONT></div></TD>

<TD align="left" valign="top"><div align="center"><FONT size="2">$110.43</FONT></div></TD>
    </TR>
  </TABLE>
</CENTER>

<P>
 <TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Pursuant to Rule&nbsp;416, promulgated under the Securities Act of 1933, as
amended, an additional undeterminable number of shares of Common Stock is
being registered to cover any adjustment in the number of shares of Common
Stock issuable pursuant to the anti-dilution provisions of the Amended and
Restated 1996 Employee Stock Purchase Plan.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Calculated on the basis of the average of the high and low sale prices of
the Registrant&#146;s Common Stock as reported on June&nbsp;4, 2003 on the Nasdaq
National Market which date is within 5 business days prior to the date of
the filing of this Registration Statement.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Estimated solely for the purpose of determining the registration fee in
accordance with Rule&nbsp;457(h).</FONT></TD>
</TR>
</TABLE>
<P align="left"><FONT size="2">The prospectus which will be part of this registration statement is a combined
prospectus under SEC Rule&nbsp;429 intended to be used for the offering of (a)&nbsp;the
shares of the Company&#146;s Common Stock registered
hereunder, and (b)&nbsp;the shares of the Company&#146;s Common Stock remaining to be
issued which have been previously registered by Registration Statements on Form
S-8 File Nos. 333-19469, 333-82113, 333-68056 and 333-105298.
</FONT>
<P align="center"><FONT size="2">&nbsp;</FONT>
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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
<P align="center"><FONT size="2">EXPLANATORY NOTE AND INCORPORATION BY REFERENCE
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement registers additional securities of the same
class as other securities for which a registration statement filed on Form&nbsp;S-8
relating to ArQule, Inc.&#146;s (the &#147;Company&#148;) Amended and Restated 1996 Employee
Stock Purchase Plan (the &#147;Plan&#148;) is already effective. In accordance with
General Instruction E to Form&nbsp;S-8, the contents of (i)&nbsp;the Company&#146;s
Registration Statement on Form&nbsp;S-8 (File No.&nbsp;333-19469) filed with the
Securities Exchange Commission (the &#147;Commission&#148;) on January&nbsp;9, 1997, relating
to the registration of 120,000 shares of the Company&#146;s common stock, $.01 par
value per share (the &#147;Common Stock&#148;) authorized for issuance under the Plan,
(ii)&nbsp;the Company&#146;s Registration Statement on Form&nbsp;S-8 (File No.&nbsp;333-82113)
filed with the Commission on July&nbsp;1, 1999, relating to the registration of
300,000 shares of Common Stock authorized for issuance under the Plan (iii)&nbsp;the
Company&#146;s Registration Statement on Form&nbsp;S-8 (File No.&nbsp;333-68056) filed with
the Commission on August&nbsp;21, 2001, relating to the registration of 100,000
shares of Common Stock authorized for issuance under the Plan, and (iv)&nbsp;the
Company&#146;s Registration Statement on Form&nbsp;S-8 (File No.&nbsp;333-105298) filed with
the Commission on May&nbsp;15, 2003, relating to the registration of 200,000 shares
of Common Stock authorized for issuance under the Plan are incorporated by
reference in their entirety in this Registration Statement.
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement provides for the registration of an additional
300,000 shares of Common Stock authorized for issuance under the Plan.
</FONT>
<P align="center"><FONT size="2">&nbsp;</FONT>
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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
<P align="center"><FONT size="2"><B>PART II<BR>
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
</FONT>

<P align="left"><FONT size="2"><B>Item&nbsp;3. <u>Incorporation of
Documents by Reference.</u></B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by the Company (File No.&nbsp;000-20713) with the
Commission under the Securities Exchange Act of 1934, as amended (&#147;Exchange
Act&#148;), are incorporated herein by reference:
</FONT>
<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(a)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">The Company&#146;s Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31,
2002, filed with the Commission on March&nbsp;31, 2003.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(b)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">The Company&#146;s Quarterly Report on Form&nbsp;10-Q for the quarter ended March
31, 2003, filed with the Commission on May&nbsp;15, 2003.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(c)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">The description of the Company&#146;s Common Stock contained in a registration
statement on Form&nbsp;8-A filed with the Commission on September&nbsp;25, 1996, and
any amendments or reports filed for the purpose of updating such
description.</FONT></TD>
</TR>
</TABLE>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Registrant after the date of this Registration
Statement pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act,
prior to the filing of a post-effective amendment which indicates that all
Common Stock offered hereby has been sold or which deregisters such Common
Stock then remaining unsold, shall be deemed to be incorporated in this
Registration Statement by reference and shall be a part hereof from the date of
filing of such documents. Any statement contained in a document incorporated
or deemed to be incorporated by reference in this Registration Statement shall
be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein or in any other
subsequently filed document which also is or is deemed to be incorporated by
reference in this Registration Statement modifies or supersedes such statement.
Any such statement so modified or superseded shall not be deemed, except as so
modified or so superseded, to constitute a part of this Registration Statement.
</FONT>
<P align="left"><FONT size="2"><B>Item&nbsp;8. <u>Exhibits</u></B>
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="75%">
<TR valign="bottom">
    <TD width="16%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="79%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;4</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
ArQule, Inc. Amended and Restated 1996 Employee Stock Purchase Plan,
as amended, filed herewith.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;5</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion of J. David Jacobs, filed herewith.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;23.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of J. David Jacobs, included in the opinion filed as
Exhibit&nbsp;5 hereto.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;23.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of PriceWaterhouseCoopers LLP, filed herewith.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;24</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Powers of Attorney of certain officers and directors of ArQule,
Inc., filed herewith.</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>
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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>
<P align="left"><FONT size="2"><B><u>SIGNATURES</u></B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the Company certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form&nbsp;S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned thereunto
duly authorized in the City of Woburn, Commonwealth of Massachusetts, on June
10, 2003.
</FONT>
<CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="55%">
    <TR valign="bottom">
      <TD width="22%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="65%">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD colspan="3" align="left" valign="top"><FONT size="2">&nbsp;ARQULE, INC</FONT><FONT size="2">&nbsp;</FONT><FONT size="2">&nbsp;</FONT></TD>
    </TR>
    <TR>
      <TD><FONT size="2">&nbsp;</FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> By: </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">/s/ Stephen A. Hill<BR>
        </FONT> <HR size="1" noshade> <FONT size="2"> Stephen A. Hill<BR>
        President and Chief Executive Officer</FONT></TD>
    </TR>
  </TABLE>
</CENTER>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
this registration statement has been signed by the following persons in the
capacities and on the dates indicated:
</FONT>
<CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="65%">
    <TR valign="bottom">
      <TD width="38%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="36%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="16%">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2"><u>Signature</u></FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> <u>Title</u> </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"><u>Date</u></FONT></TD>
    </TR>
    <TR>
      <TD valign="top">&nbsp;</TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp; </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Stephen A. Hill
        <HR size="1" noshade>
        Stephen A. Hill</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> President, Chief Executive
        Officer and Director (Principal Executive Officer) </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">June&nbsp;10, 2003</FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ David C. Hastings
        <HR size="1" noshade>
        David C. Hastings</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Vice President, Chief Financial
        Officer and Treasurer (Principal Accounting and Financial Officer) </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">June&nbsp;10, 2003</FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Ariel Elia
        <HR size="1" noshade>
        Ariel Elia</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Chairman of the Board </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">June&nbsp;10, 2003</FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Laura Avakian
        <HR size="1" noshade>
        Laura Avakian</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Director </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">June&nbsp;10, 2003</FONT></TD>
    </TR>
    <TR>
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR>
      <TD valign="top"><FONT size="2">/s/ Timothy C. Barabe
        <HR size="1" noshade>
        Timothy C. Barabe</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Director </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">June&nbsp;10, 2003</FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Werner Cautreels
        <HR size="1" noshade>
        Werner Cautreels</FONT></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><FONT size="2">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><FONT size="2">June&nbsp;10, 2003 </FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Tuan Ha-Ngoc
        <HR size="1" noshade>
        Tuan Ha-Ngoc </FONT></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><FONT size="2">Director</FONT></TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top"><FONT size="2">June&nbsp;10, 2003 </FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2"> /s/ Michael Rosenblatt
        <HR size="1" noshade>
        Michael Rosenblatt</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Director </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">June&nbsp;10, 2003</FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Patrick J. Zenner
        <HR size="1" noshade>
        Patrick J. Zenner</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Director </FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2">June&nbsp;3, 2003</FONT></TD>
    </TR>
  </TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>
<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<P align="left"><FONT size="2"><B><u>INDEX TO EXHIBITS</u></B>
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="65%">
<TR valign="bottom">
    <TD width="18%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="77%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;4</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
ArQule, Inc. Amended and Restated 1996 Employee Stock
Purchase Plan, as amended, filed herewith.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;5</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion of J. David Jacobs, filed herewith.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;23.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of J. David Jacobs, included in the opinion filed as
Exhibit&nbsp;5 hereto.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;23.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of PricewaterhouseCoopers LLP, filed herewith.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">Exhibit&nbsp;24</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Powers of Attorney of certain officers and directors of
ArQule, Inc., filed herewith.</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>
</BODY>
</HTML>
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sv8
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
ARQULE, INC.
(Exact Name of registrant as specified in its charter)
Delaware
58-1959440
(State or other jurisdiction of
(I.R.S. Employer
incorporation or organization)
Identification No.)
19 Presidential Way,
Woburn, Massachusetts 01801
(Address, including zip code, of principal executive offices)
ArQule, Inc. Amended and Restated 1996 Employee
  Stock Purchase Plan
(Full title of the plan)
Dr. Stephen A. Hill
President and Chief Executive Officer
ArQule, Inc.
19 Presidential Way,
Woburn, Massachusetts 01801
(781) 994-0300
(Name, address, including zip code, and telephone number including area code,
of agent for service)
Copy to:
Richard E. Baltz, Esq.
Arnold & Porter
555 12th Street, N.W.
Washington, D.C. 20004
(202) 942-5124
Calculation of Registration Fee
Proposed maximum
Proposed maximum
Title of securities
Amount to be
offering price per
aggregate offering
Amount of
to be registered
registered (1)
unit (2)(3)
price (3)
registration fee
Common Stock,
$.01 par value
300,000
$4.55
$1,365,000
$110.43
(1)
Pursuant to Rule 416, promulgated under the Securities Act of 1933, as
amended, an additional undeterminable number of shares of Common Stock is
being registered to cover any adjustment in the number of shares of Common
Stock issuable pursuant to the anti-dilution provisions of the Amended and
Restated 1996 Employee Stock Purchase Plan.
(2)
Calculated on the basis of the average of the high and low sale prices of
the Registrant's Common Stock as reported on June 4, 2003 on the Nasdaq
National Market which date is within 5 business days prior to the date of
the filing of this Registration Statement.
(3)
Estimated solely for the purpose of determining the registration fee in
accordance with Rule 457(h).
The prospectus which will be part of this registration statement is a combined
prospectus under SEC Rule 429 intended to be used for the offering of (a) the
shares of the Company's Common Stock registered
hereunder, and (b) the shares of the Company's Common Stock remaining to be
issued which have been previously registered by Registration Statements on Form
S-8 File Nos. 333-19469, 333-82113, 333-68056 and 333-105298.
EXPLANATORY NOTE AND INCORPORATION BY REFERENCE
This Registration Statement registers additional securities of the same
class as other securities for which a registration statement filed on Form S-8
relating to ArQule, Inc.'s (the "Company") Amended and Restated 1996 Employee
Stock Purchase Plan (the "Plan") is already effective. In accordance with
General Instruction E to Form S-8, the contents of (i) the Company's
Registration Statement on Form S-8 (File No. 333-19469) filed with the
Securities Exchange Commission (the "Commission") on January 9, 1997, relating
to the registration of 120,000 shares of the Company's common stock, $.01 par
value per share (the "Common Stock") authorized for issuance under the Plan,
(ii) the Company's Registration Statement on Form S-8 (File No. 333-82113)
filed with the Commission on July 1, 1999, relating to the registration of
300,000 shares of Common Stock authorized for issuance under the Plan (iii) the
Company's Registration Statement on Form S-8 (File No. 333-68056) filed with
the Commission on August 21, 2001, relating to the registration of 100,000
shares of Common Stock authorized for issuance under the Plan, and (iv) the
Company's Registration Statement on Form S-8 (File No. 333-105298) filed with
the Commission on May 15, 2003, relating to the registration of 200,000 shares
of Common Stock authorized for issuance under the Plan are incorporated by
reference in their entirety in this Registration Statement.
This Registration Statement provides for the registration of an additional
300,000 shares of Common Stock authorized for issuance under the Plan.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of
Documents by Reference.
The following documents filed by the Company (File No. 000-20713) with the
Commission under the Securities Exchange Act of 1934, as amended ("Exchange
Act"), are incorporated herein by reference:
(a)
The Company's Annual Report on Form 10-K for the year ended December 31,
2002, filed with the Commission on March 31, 2003.
(b)
The Company's Quarterly Report on Form 10-Q for the quarter ended March
31, 2003, filed with the Commission on May 15, 2003.
(c)
The description of the Company's Common Stock contained in a registration
statement on Form 8-A filed with the Commission on September 25, 1996, and
any amendments or reports filed for the purpose of updating such
description.
All documents filed by the Registrant after the date of this Registration
Statement pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act,
prior to the filing of a post-effective amendment which indicates that all
Common Stock offered hereby has been sold or which deregisters such Common
Stock then remaining unsold, shall be deemed to be incorporated in this
Registration Statement by reference and shall be a part hereof from the date of
filing of such documents. Any statement contained in a document incorporated
or deemed to be incorporated by reference in this Registration Statement shall
be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein or in any other
subsequently filed document which also is or is deemed to be incorporated by
reference in this Registration Statement modifies or supersedes such statement.
Any such statement so modified or superseded shall not be deemed, except as so
modified or so superseded, to constitute a part of this Registration Statement.
Item 8.
Exhibits
Exhibit 4
ArQule, Inc. Amended and Restated 1996 Employee Stock Purchase Plan,
as amended, filed herewith.
Exhibit 5
Opinion of J. David Jacobs, filed herewith.
Exhibit 23.1
Consent of J. David Jacobs, included in the opinion filed as
Exhibit 5 hereto.
Exhibit 23.2
Consent of PriceWaterhouseCoopers LLP, filed herewith.
Exhibit 24
Powers of Attorney of certain officers and directors of ArQule,
Inc., filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the Company certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned thereunto
duly authorized in the City of Woburn, Commonwealth of Massachusetts, on June
10, 2003.
ARQULE, INC
By:
/s/ Stephen A. Hill
Stephen A. Hill
President and Chief Executive Officer
Pursuant to the requirements of the Securities Act of 1933, as amended,
this registration statement has been signed by the following persons in the
capacities and on the dates indicated:
Signature
Title
Date
/s/ Stephen A. Hill
Stephen A. Hill
President, Chief Executive
        Officer and Director (Principal Executive Officer)
June 10, 2003
/s/ David C. Hastings
David C. Hastings
Vice President, Chief Financial
        Officer and Treasurer (Principal Accounting and Financial Officer)
June 10, 2003
/s/ Ariel Elia
Ariel Elia
Chairman of the Board
June 10, 2003
/s/ Laura Avakian
Laura Avakian
Director
June 10, 2003
/s/ Timothy C. Barabe
Timothy C. Barabe
Director
June 10, 2003
/s/ Werner Cautreels
Werner Cautreels
Director
June 10, 2003
/s/ Tuan Ha-Ngoc
Tuan Ha-Ngoc
Director
June 10, 2003
/s/ Michael Rosenblatt
Michael Rosenblatt
Director
June 10, 2003
/s/ Patrick J. Zenner
Patrick J. Zenner
Director
June 3, 2003
INDEX TO EXHIBITS
Exhibit 4
ArQule, Inc. Amended and Restated 1996 Employee Stock
Purchase Plan, as amended, filed herewith.
Exhibit 5
Opinion of J. David Jacobs, filed herewith.
Exhibit 23.1
Consent of J. David Jacobs, included in the opinion filed as
Exhibit 5 hereto.
Exhibit 23.2
Consent of PricewaterhouseCoopers LLP, filed herewith.
Exhibit 24
Powers of Attorney of certain officers and directors of
ArQule, Inc., filed herewith.