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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
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<P align="center" style="font-size: 10pt">As filed with the Securities and Exchange Commission on February&nbsp;25, 2004


<P align="right" style="font-size: 10pt"><B>Registration No.&nbsp;333-</B><U>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</U>



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<P align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>


<P align="center" style="font-size: 10pt"><HR size="1" noshade width="25%" align="center">
<P align="center" style="font-size: 18pt"><B>FORM S-8</B>


<P align="center" style="font-size: 10pt"><B>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</B>

<P align="center" style="font-size: 10pt"><HR size="1" noshade width="25%" align="center">

<P align="center" style="font-size: 24pt"><B>ILEX ONCOLOGY, INC.</B>

<DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>


<DIV align="center">
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    <TD align="center" valign="top"><B>Delaware</B><BR>
(State or other jurisdiction of<BR>
incorporation or organization)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>74-2699185</B><BR>
(I.R.S. Employer<BR>
Identification No.)</TD>
</TR>

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<DIV align="center">
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    <TD width="47%">&nbsp;</TD>
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<TR valign="bottom">
    <TD align="center" valign="top"><B>4545 Horizon Hill Boulevard<BR>
San Antonio, Texas</B><BR>
(Address of Principal Executive Offices)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>78229</B><BR>
(Zip Code)</TD>
</TR>

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</TABLE>
</DIV>



<P align="center" style="font-size: 10pt"><B>ILEX Oncology, Inc. 1995 Stock Option Plan<BR>
ILEX Oncology, Inc. 1996 Non-Employee Director Stock Option Plan<BR>
2000 Employee Stock Compensation Plan</B><BR>
(Full title of the plan)


<P align="center" style="font-size: 10pt"><HR size="1" noshade width="25%" align="center">


<P align="center" style="font-size: 10pt"><B>Ronald G. Tefteller<BR>
Vice President and General Counsel<BR>
ILEX Oncology, Inc.<BR>
4545 Horizon Hill Boulevard<BR>
San Antonio, Texas 78229</B><BR>
(Name and address of agent for service)





<P align="center" style="font-size: 10pt"><B>(210)&nbsp;949-8200</B><BR>
(Telephone number, including area code, of agent for service)


<P align="center" style="font-size: 10pt"><HR size="1" noshade width="25%" align="center">

<P align="center" style="font-size: 10pt">With Copies to:<BR>
<B>Phillip M. Renfro<BR>
Derrek Weaver<BR>
Fulbright &#038; Jaworski L.L.P.<BR>
300 Convent Street, Suite&nbsp;2200<BR>
San Antonio, Texas 78205<BR>
(210)&nbsp;224-5575</B>


<P align="center" style="font-size: 10pt"><HR size="1" noshade width="25%" align="center">


<P align="center" style="font-size: 8pt"><B>CALCULATION OF REGISTRATION FEE</B>
<P>
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    <TD width="14%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="14%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="4%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
</TR>

<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Proposed</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Proposed maximum</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Title of securities</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Amount to</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>maximum offering</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>aggregate offering</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>Amount of</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>to be registered</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>be registered</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>price per share<SUP>(2)</SUP></B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>price<SUP>(2)</SUP></B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3"><B>registration fee</B><HR size="1" noshade></TD>
</TR>

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    <TD><DIV style="margin-left:10px; text-indent:-10px">Common Stock
$.01 par value</DIV></TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="center">1,961,922 shares<sup>(1)</sup></TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">20.655</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">40,523,499</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">5,134</TD>
    <TD>&nbsp;</TD>
</TR>

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</TABLE>
</DIV>



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    <TD width="1%" nowrap align="left">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Represents an additional 1,250,000 shares of Common Stock issuable under the Registrant&#146;s 2000 Employee Stock
Compensation Plan, an additional 53,729 shares of Common Stock issuable under the ILEX Oncology, Inc. 1996
Non-Employee Director Stock Option Plan and an additional 658,193 shares of Common Stock issuable under the ILEX
Oncology, Inc. 1995 Stock Option Plan.
</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and (h)&nbsp;and based on
the average of the high and the low sales price of a share of Common Stock on the Nasdaq National Market System on February&nbsp;24, 2004.</TD>
</TR>

</TABLE>


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<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<!-- TOC -->
<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

<P><CENTER>
<TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
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</TR>
<TR><TD colspan="9"><A HREF="#000">PART II</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Documents by Reference</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;4. Description of Securities</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;6. Indemnification of Directors and Officers</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;7. Exemption from Registration Claimed</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;8. Exhibits</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;9. Undertakings</A></TD></TR>
<TR><TD colspan="9"><A HREF="#008">SIGNATURES</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#009"> INDEX TO EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="d12982exv4w5.htm">1995 Stock Option Plan</A></TD></TR>
<TR><TD colspan="9"><A HREF="d12982exv4w6.htm">1996 Non-Employee Director Stock Option Plan</A></TD></TR>
<TR><TD colspan="9"><A HREF="d12982exv4w7.htm">2000 Employee Stock Compensation Plan</A></TD></TR>
<TR><TD colspan="9"><A HREF="d12982exv5w1.htm">Opinion/Consent of Fulbright & Jaworski L.L.P.</A></TD></TR>
<TR><TD colspan="9"><A HREF="d12982exv23w2.htm">Consent of Ernst & Young LLP</A></TD></TR>
</TABLE>
</CENTER>
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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>




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<DIV align="left"><A NAME="000"></A></DIV>

<P align="center" style="font-size: 10pt"><B>PART II</B>



<P align="center" style="font-size: 10pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>


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<DIV align="left"><A NAME="001"></A></DIV>

<P>
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<TR>
    <TD width="1%"></TD>
    <TD width="99%"></TD>
</TR>
<TR valign="top">
    <TD nowrap><B>Item&nbsp;3.</B>&nbsp;</TD>
    <TD><B>Incorporation of Documents by Reference</B></TD>
</TR>
</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A Registration Statement on Form S-8 (file No.&nbsp;333-25537) was filed with
the Securities and Exchange Commission (the &#147;Commission&#148;) on April&nbsp;21, 1997
covering the registration of 171,271 shares initially authorized for issuance
under the ILEX Oncology, Inc. 1996 Non-Employee Director Stock Option Plan (the
&#147;1996 Plan&#148;) and 1,141,807 shares initially authorized for issuance under
the ILEX Oncology, Inc. 1995 Stock Option Plan (the &#147;1995 Plan&#148;).


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A Registration Statement on Form S-8 (file No.&nbsp;333-38302) was filed with
the Commission on June&nbsp;1, 2000 covering the registration of
3,000,000 shares initially
authorized for issuance under the 2000 Employee Stock Compensation Plan (the
&#147;2000 Plan&#148;).


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement on Form S-8 is filed by ILEX Oncology, Inc.
(the &#147;Company&#148; or the &#147;Registrant&#148;), a Delaware corporation, pursuant to
General Instruction E to Form S-8 to register an additional 1,961,962 shares of
common stock, $.01 par value per share (&#147;Common Stock&#148;), of the Company, 53,729
of which additional shares are being registered for use under the 1996 Plan, as
amended, 658,193 of which additional shares are being registered for use under
the 1995 Plan, as amended, and 1,250,000 of which additional shares are being
registered for use under the 2000 Plan, as amended.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant hereby incorporates the following documents previously
filed by the Registrant with the Commission by reference in this Registration
Statement:


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Annual Report on Form 10-K for the year ended
December&nbsp;31, 2002 filed on March&nbsp;14, 2003;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s definitive proxy statement for the Company&#146;s
annual meeting filed on April&nbsp;11, 2003;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Quarterly Reports on Form 10-Q filed on May&nbsp;13,
2003; August&nbsp;14, 2003; and November&nbsp;13, 2003;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The Company&#146;s Current Reports on Form 8-K filed on April&nbsp;14,
2003; April&nbsp;29, 2003; July&nbsp;21, 2003; August&nbsp;4, 2003; August&nbsp;14,
2003; October&nbsp;22, 2003; and January&nbsp;27, 2004; and</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">&#149;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>The description of the Company&#146;s Common Stock included in the
Company&#146;s Registration Statement on Form 8-A, filed by the Company
pursuant to the Securities Exchange Act of 1934, as amended (the
&#147;Exchange Act&#148;), on February&nbsp;14, 1997.</TD>
</TR>

</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by the Registrant pursuant to Sections&nbsp;13(a), 13(c),
14 and 15(d) of the Exchange Act subsequent to the filing hereof and prior to
the filing of a post-effective amendment, which indicates that all securities
offered have been sold or which deregisters all securities then remaining
unsold, shall be deemed to be incorporated by reference in this Registration
Statement and to be a part hereof from the date of filing such documents.

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<DIV align="left"><A NAME="002"></A></DIV>

<P>
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<TR>
    <TD width="1%"></TD>
    <TD width="99%"></TD>
</TR>
<TR valign="top">
    <TD nowrap><B>Item&nbsp;4.</B>&nbsp;</TD>
    <TD><B>Description of Securities<br></B>
Not Applicable.</TD>
</TR>
</TABLE>


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">
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<DIV align="left"><A NAME="003"></A></DIV>

<P>
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<TR>
    <TD width="1%"></TD>
    <TD width="99%"></TD>
</TR>
<TR valign="top">
    <TD nowrap><B>Item&nbsp;5.</B>&nbsp;</TD>
    <TD><B>Interests of Named Experts and Counsel.<br></B>
Not Applicable.</TD>
</TR>
</TABLE>

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<DIV align="left"><A NAME="004"></A></DIV>

<P>
<TABLE width="100%" border="0" cellpadding="2" cellspacing="0" style="font-size: 10pt; background: transparent; color: #000000">
<TR>
    <TD width="1%"></TD>
    <TD width="99%"></TD>
</TR>
<TR valign="top">
    <TD nowrap><B>Item&nbsp;6.</B>&nbsp;</TD>
    <TD><B>Indemnification of Directors and Officers</B></TD>
</TR>
</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the Delaware General Corporation Laws empowers the
Registrant to, and the Bylaws of the Registrant provide that it shall,
indemnify any person who was or is a party or is threatened to be made a party
to any threatened, pending or completed action, suit or proceeding by reason of
the fact that he is or was a director, officer, employee or agent of the
Registrant, or is or was serving at the request of the Registrant as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise, against expenses, judgments, fines and
amounts paid in settlement actually and reasonably incurred by him in
connection with such action, suit or proceeding if he acted in good faith and
in a manner he reasonably believed to be in or not opposed to the best interest
of the Registrant, and, with respect to any criminal action or proceeding, had
no reasonable cause to believe his conduct was unlawful; except that, in the
case of an action or suit by or in the right of the Registrant, no
indemnification may be made in respect of any claim, issue or matter as to
which such person shall have been adjudged to be liable for negligence or
misconduct in the performance of his duty to the Registrant unless and only to
the extent that the Court of Chancery or the court in which such action or suit
was brought shall determine that such person is fairly and reasonably entitled
to indemnity for proper expenses.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar as indemnification for liabilities arising under the Securities
Act of 1933 (the &#147;Securities Act&#148;) may be permitted to directors, officers or
persons controlling the Company pursuant to the foregoing provisions, the
Company has been informed that in the opinion of the Commission, such
indemnification is against public policy as expressed in the Securities Act and
is therefore unenforceable.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant maintains directors&#146; and officers&#146; liability insurance that
covers the directors and officers of the Registrant.

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<DIV align="left"><A NAME="005"></A></DIV>

<P>
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<TR>
    <TD width="1%"></TD>
    <TD width="99%"></TD>
</TR>
<TR valign="top">
    <TD nowrap><B>Item&nbsp;7.</B>&nbsp;</TD>
    <TD><B>Exemption from Registration Claimed<br></B>
Not applicable.</TD>
</TR>
</TABLE>

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<DIV align="left"><A NAME="006"></A></DIV>

<P>
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<TR>
    <TD width="1%"></TD>
    <TD width="99%"></TD>
</TR>
<TR valign="top">
    <TD nowrap><B>Item&nbsp;8.</B>&nbsp;</TD>
    <TD><B>Exhibits</B></TD>
</TR>
</TABLE>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="75%">
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<TR valign="bottom">
    <TD width="9%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="86%">&nbsp;</TD>
</TR>
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<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amended and Restated Certificate of Incorporation of the Company
filed May&nbsp;31, 2000 (Incorporated herein by reference to Exhibit&nbsp;3.1
of the Company&#146;s Quarterly Report on Form&nbsp;10-Q filed August&nbsp;8, 2000)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Bylaws of the Company, as amended (Incorporated herein by reference
to Exhibit&nbsp;3.2 of the Company&#146;s Registration Statement No.&nbsp;333-17769
on Form&nbsp;S-1 filed December&nbsp;12, 1996, as amended)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen of certificate representing Common Stock, $.01 par value,
of the Company (Incorporated herein by reference to Exhibit&nbsp;4.1 of
the Company&#146;s Registration Statement No.&nbsp;333-17769 on Form&nbsp;S-1 filed
December&nbsp;12, 1996, as amended)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Rights Agreement dated April&nbsp;10, 2001 by and between ILEX Oncology,
Inc. and American Stock Transfer &#038; Trust Co. which includes as
Exhibit&nbsp;A the Form of Certificate of Designations of Series&nbsp;I
Preferred Stock, as Exhibit&nbsp;B the Form of Rights Certificate and as
Exhibit&nbsp;C the Summary of Rights to Purchase Common Stock
(Incorporated herein by reference to Exhibit&nbsp;4.1 to the Company&#146;s
Form&nbsp;8-K filed April&nbsp;11, 2001)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*4.5
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">The ILEX Oncology, Inc. 1995 Stock Option Plan, as amended through
February&nbsp;25, 2004</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="75%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="9%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="86%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*4.6
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">The ILEX Oncology, Inc. 1996 Non-Employee Director Stock Option
Plan, as amended through February&nbsp;25, 2004</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*4.7
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">The 2000 Employee Stock Compensation Plan, as amended through
February&nbsp;25, 2004</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Fulbright &#038; Jaworski L.L.P. as to the legality of the
securities being registered</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Fulbright &#038; Jaworski L.L.P. (included in exhibit 5.1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Powers of Attorney from the members of the Board of Directors of the
Registrant (contained on signature page hereof)</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>



<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">*</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Filed herewith</TD>
</TR>

</TABLE>

<!-- link2 "Item&nbsp;9. Undertakings" -->
<DIV align="left"><A NAME="007"></A></DIV>

<P>
<TABLE width="100%" border="0" cellpadding="2" cellspacing="0" style="font-size: 10pt; background: transparent; color: #000000">
<TR>
    <TD width="1%"></TD>
    <TD width="99%"></TD>
</TR>
<TR valign="top">
    <TD nowrap><B>Item&nbsp;9.</B>&nbsp;</TD>
    <TD><B>Undertakings</B></TD>
</TR>
</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The undersigned Registrant hereby undertakes:


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement:


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;To include any prospectus required by Section&nbsp;10(a)(3) of the
Securities Act;


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;To reflect in the prospectus any facts or events arising after the
effective date of this Registration Statement (or the most recent
post-effective amendment hereof) which, individually or in the aggregate,
represent a fundamental change in the information set forth in this
Registration Statement; and


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;To include any material information with respect to the plan of
distribution not previously disclosed in this Registration Statement or any
material change to such information in this Registration Statement;

<P align="left" style="font-size: 10pt"><I>provided, however, </I>that paragraphs (i)&nbsp;and (ii)&nbsp;do not apply if the information
required to be included in a post-effective amendment by those paragraphs is
contained in periodic reports filed by the Registrant pursuant to Section&nbsp;13 or
Section 15(d) of the Exchange Act that are incorporated by reference in this
Registration Statement.



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered herein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;To remove from registration by means of a post-effective amendment any
of the securities being registered that remain unsold at the termination of the
offering.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
Registrant&#146;s annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act that is incorporated by reference in this Registration Statement
shall be deemed to be a new registration statement relating to the securities
offered herein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Commission such indemnification is
against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Registrant of expenses incurred or
paid by a director, officer or controlling


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<P align="left" style="font-size: 10pt">person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the
Securities Act and will be governed by the final adjudication of such issue.


<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="008"></A></DIV>

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Antonio, State of Texas, on February&nbsp;24, 2004.

<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top">&nbsp;</TD>
    <TD colspan="3"><B>ILEX ONCOLOGY, INC.</B><BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000">/s/ Jeffrey H. Buchalter
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2">Jeffrey H. Buchalter&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2">President and Chief Executive Officer&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>

<P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>




<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Ronald G. Tefteller and Mark P. Mellin,
his or her true and lawful agent, proxy and attorney-in-fact, each acting
alone, with full power of substitution and resubstitution, for him or her and
in his or her name, place and stead, in any and all capacities, to (i)&nbsp;act on,
sign and file with the SEC any and all amendments (including post-effective
amendments) to this Registration Statement filed pursuant to Rule 462(b) under
the Securities Act together with all schedules and exhibits thereto; (ii)&nbsp;act
on, sign and file such certificates, instruments, agreements and other
documents as may be necessary or appropriate in connection therewith; and (iii)
take any and all actions which may be necessary or appropriate to be done, as
fully for all intents and purposes as he or she might or could do in person,
hereby approving, ratifying and confirming all that such agent, proxy and
attorney-in-fact or any of his substitutes may lawfully do or cause to be done
by virtue thereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="85%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="29%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="50%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>SIGNATURE</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>TITLE</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>DATE</B><HR size="1" noshade></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" nowrap valign="top">/s/ Joy A. Amundson<BR>
<HR size="1" noshade>
Joy A. Amundson</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Chairman of the Board
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 25, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ Jeffrey H. Buchalter<BR>
<HR size="1" noshade>
Jeffrey H. Buchalter</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
President, Chief Executive Officer and Director<br>
(principal executive officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 24, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ Mark P. Mellin<BR>
<HR size="1" noshade>
Mark P. Mellin</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Senior Vice President and Chief Financial Officer<br>
(principal financial and accounting officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 25, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ Joseph S. Bailes, M.D.<BR>
<HR size="1" noshade>
Joseph S. Bailes, M.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 24, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ Jason S. Fisherman, M.D.<BR>
<HR size="1" noshade>
Jason S. Fisherman, M.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 25, 2004</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="85%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="29%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="50%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center"><B>SIGNATURE</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>TITLE</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>DATE</B><HR size="1" noshade></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ Richard L. Love<BR>
<HR size="1" noshade>
Richard L. Love</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 24, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ Victor P. Micati<BR>
<HR size="1" noshade>
Victor P. Micati</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 25, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ Daniel D. Von Hoff, M.D.<BR>
<HR size="1" noshade>
Daniel D. Von Hoff, M.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 25, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ Mark E. Watson, Jr.<BR>
<HR size="1" noshade>
Mark E. Watson, Jr.</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 24, 2004</TD>
</TR>

<TR valign="bottom" style="padding-top: 1em">
    <TD align="center" nowrap valign="top">/s/ Gary V. Woods<BR>
<HR size="1" noshade>
Gary V. Woods</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">February 24, 2004</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<P align="center" style="font-size: 10pt"><B>INDEX TO EXHIBITS</B>


<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link2 " INDEX TO EXHIBITS" -->
<DIV align="left"><A NAME="009"></A></DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="65%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="8%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="87%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>&nbsp;</B></TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Number</B><HR size="1" noshade></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center"><B>Description of Exhibit</B><HR size="1" noshade></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Amended and Restated Certificate of Incorporation of the
Company filed May&nbsp;31, 2000 (Incorporated herein by reference to
Exhibit&nbsp;3.1 of the Company&#146;s Quarterly Report on Form&nbsp;10-Q
filed August&nbsp;8, 2000)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Bylaws of the Company, as amended (Incorporated herein by
reference to Exhibit&nbsp;3.2 of the Company&#146;s Registration
Statement No.&nbsp;333-17769 on Form&nbsp;S-1 filed December&nbsp;12, 1996, as
amended)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Specimen of certificate representing Common Stock, $.01 par
value, of the Company (Incorporated herein by reference to
Exhibit&nbsp;4.1 of the Company&#146;s Registration Statement No.
333-17769 on Form&nbsp;S-1 filed December&nbsp;12, 1996, as amended)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.4
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Rights Agreement dated April&nbsp;10, 2001 by and between ILEX
Oncology, Inc. and American Stock Transfer &#038; Trust Co. which
includes as Exhibit&nbsp;A the Form of Certificate of Designations
of Series&nbsp;I Preferred Stock, as Exhibit&nbsp;B the Form of Rights
Certificate and as Exhibit&nbsp;C the Summary of Rights to Purchase
Common Stock (Incorporated herein by reference to Exhibit&nbsp;4.1
to the Company&#146;s Form&nbsp;8-K filed April&nbsp;11, 2001)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*4.5
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">The ILEX Oncology, Inc. 1995 Stock Option Plan, as amended
through February&nbsp;25, 2004</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*4.6
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">The ILEX Oncology, Inc. 1996 Non-Employee Director Stock Option
Plan, as amended through February&nbsp;25, 2004</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*4.7
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">The 2000 Employee Stock Compensation Plan, as amended through
February&nbsp;25, 2004</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Fulbright &#038; Jaworski L.L.P. as to the legality of
the securities being registered</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Fulbright &#038; Jaworski L.L.P. (included in exhibit 5.1)</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP</TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">*24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Powers of Attorney from the members of the Board of Directors
of the Registrant (contained on signature page hereof)</TD>
</TR>

<!-- End Table Body -->
</TABLE>
</DIV>




<P>
<HR size="1" width="18%" align="left" noshade>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="1%" nowrap align="right">*</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Filed herewith</TD>
</TR>

</TABLE>




<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

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sv8
Table of Contents
As filed with the Securities and Exchange Commission on February 25, 2004
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
ILEX ONCOLOGY, INC.
(Exact name of registrant as specified in its charter)
Delaware
(State or other jurisdiction of
incorporation or organization)
74-2699185
(I.R.S. Employer
Identification No.)
4545 Horizon Hill Boulevard
San Antonio, Texas
(Address of Principal Executive Offices)
78229
(Zip Code)
ILEX Oncology, Inc. 1995 Stock Option Plan
ILEX Oncology, Inc. 1996 Non-Employee Director Stock Option Plan
2000 Employee Stock Compensation Plan
(Full title of the plan)
Ronald G. Tefteller
Vice President and General Counsel
ILEX Oncology, Inc.
4545 Horizon Hill Boulevard
San Antonio, Texas 78229
(Name and address of agent for service)
(210) 949-8200
(Telephone number, including area code, of agent for service)
With Copies to:
Phillip M. Renfro
Derrek Weaver
Fulbright & Jaworski L.L.P.
300 Convent Street, Suite 2200
San Antonio, Texas 78205
(210) 224-5575
CALCULATION OF REGISTRATION FEE
Proposed
Proposed maximum
Title of securities
Amount to
maximum offering
aggregate offering
Amount of
to be registered
be registered
price per share
(2)
price
(2)
registration fee
Common Stock
$.01 par value
1,961,922 shares
(1)
$
20.655
$
40,523,499
$
5,134
(1)
Represents an additional 1,250,000 shares of Common Stock issuable under the Registrant's 2000 Employee Stock
Compensation Plan, an additional 53,729 shares of Common Stock issuable under the ILEX Oncology, Inc. 1996
Non-Employee Director Stock Option Plan and an additional 658,193 shares of Common Stock issuable under the ILEX
Oncology, Inc. 1995 Stock Option Plan.
(2)
Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and (h) and based on
the average of the high and the low sales price of a share of Common Stock on the Nasdaq National Market System on February 24, 2004.
TABLE OF CONTENTS
PART II
Item 3. Incorporation of Documents by Reference
Item 4. Description of Securities
Item 5. Interests of Named Experts and Counsel.
Item 6. Indemnification of Directors and Officers
Item 7. Exemption from Registration Claimed
Item 8. Exhibits
Item 9. Undertakings
SIGNATURES
INDEX TO EXHIBITS
1995 Stock Option Plan
1996 Non-Employee Director Stock Option Plan
2000 Employee Stock Compensation Plan
Opinion/Consent of Fulbright & Jaworski L.L.P.
Consent of Ernst & Young LLP
Table of Contents
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference
A Registration Statement on Form S-8 (file No. 333-25537) was filed with
the Securities and Exchange Commission (the "Commission") on April 21, 1997
covering the registration of 171,271 shares initially authorized for issuance
under the ILEX Oncology, Inc. 1996 Non-Employee Director Stock Option Plan (the
"1996 Plan") and 1,141,807 shares initially authorized for issuance under
the ILEX Oncology, Inc. 1995 Stock Option Plan (the "1995 Plan").
A Registration Statement on Form S-8 (file No. 333-38302) was filed with
the Commission on June 1, 2000 covering the registration of
3,000,000 shares initially
authorized for issuance under the 2000 Employee Stock Compensation Plan (the
"2000 Plan").
This Registration Statement on Form S-8 is filed by ILEX Oncology, Inc.
(the "Company" or the "Registrant"), a Delaware corporation, pursuant to
General Instruction E to Form S-8 to register an additional 1,961,962 shares of
common stock, $.01 par value per share ("Common Stock"), of the Company, 53,729
of which additional shares are being registered for use under the 1996 Plan, as
amended, 658,193 of which additional shares are being registered for use under
the 1995 Plan, as amended, and 1,250,000 of which additional shares are being
registered for use under the 2000 Plan, as amended.
The Registrant hereby incorporates the following documents previously
filed by the Registrant with the Commission by reference in this Registration
Statement:
•
The Company's Annual Report on Form 10-K for the year ended
December 31, 2002 filed on March 14, 2003;
•
The Company's definitive proxy statement for the Company's
annual meeting filed on April 11, 2003;
•
The Company's Quarterly Reports on Form 10-Q filed on May 13,
2003; August 14, 2003; and November 13, 2003;
•
The Company's Current Reports on Form 8-K filed on April 14,
2003; April 29, 2003; July 21, 2003; August 4, 2003; August 14,
2003; October 22, 2003; and January 27, 2004; and
•
The description of the Company's Common Stock included in the
Company's Registration Statement on Form 8-A, filed by the Company
pursuant to the Securities Exchange Act of 1934, as amended (the
"Exchange Act"), on February 14, 1997.
All documents filed by the Registrant pursuant to Sections 13(a), 13(c),
14 and 15(d) of the Exchange Act subsequent to the filing hereof and prior to
the filing of a post-effective amendment, which indicates that all securities
offered have been sold or which deregisters all securities then remaining
unsold, shall be deemed to be incorporated by reference in this Registration
Statement and to be a part hereof from the date of filing such documents.
Item 4.
Description of Securities
Not Applicable.
Table of Contents
Item 5.
Interests of Named Experts and Counsel.
Not Applicable.
Item 6.
Indemnification of Directors and Officers
Section 145 of the Delaware General Corporation Laws empowers the
Registrant to, and the Bylaws of the Registrant provide that it shall,
indemnify any person who was or is a party or is threatened to be made a party
to any threatened, pending or completed action, suit or proceeding by reason of
the fact that he is or was a director, officer, employee or agent of the
Registrant, or is or was serving at the request of the Registrant as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise, against expenses, judgments, fines and
amounts paid in settlement actually and reasonably incurred by him in
connection with such action, suit or proceeding if he acted in good faith and
in a manner he reasonably believed to be in or not opposed to the best interest
of the Registrant, and, with respect to any criminal action or proceeding, had
no reasonable cause to believe his conduct was unlawful; except that, in the
case of an action or suit by or in the right of the Registrant, no
indemnification may be made in respect of any claim, issue or matter as to
which such person shall have been adjudged to be liable for negligence or
misconduct in the performance of his duty to the Registrant unless and only to
the extent that the Court of Chancery or the court in which such action or suit
was brought shall determine that such person is fairly and reasonably entitled
to indemnity for proper expenses.
Insofar as indemnification for liabilities arising under the Securities
Act of 1933 (the "Securities Act") may be permitted to directors, officers or
persons controlling the Company pursuant to the foregoing provisions, the
Company has been informed that in the opinion of the Commission, such
indemnification is against public policy as expressed in the Securities Act and
is therefore unenforceable.
The Registrant maintains directors' and officers' liability insurance that
covers the directors and officers of the Registrant.
Item 7.
Exemption from Registration Claimed
Not applicable.
Item 8.
Exhibits
4.1
Amended and Restated Certificate of Incorporation of the Company
filed May 31, 2000 (Incorporated herein by reference to Exhibit 3.1
of the Company's Quarterly Report on Form 10-Q filed August 8, 2000)
4.2
Bylaws of the Company, as amended (Incorporated herein by reference
to Exhibit 3.2 of the Company's Registration Statement No. 333-17769
on Form S-1 filed December 12, 1996, as amended)
4.3
Specimen of certificate representing Common Stock, $.01 par value,
of the Company (Incorporated herein by reference to Exhibit 4.1 of
the Company's Registration Statement No. 333-17769 on Form S-1 filed
December 12, 1996, as amended)
4.4
Rights Agreement dated April 10, 2001 by and between ILEX Oncology,
Inc. and American Stock Transfer & Trust Co. which includes as
Exhibit A the Form of Certificate of Designations of Series I
Preferred Stock, as Exhibit B the Form of Rights Certificate and as
Exhibit C the Summary of Rights to Purchase Common Stock
(Incorporated herein by reference to Exhibit 4.1 to the Company's
Form 8-K filed April 11, 2001)
*4.5
The ILEX Oncology, Inc. 1995 Stock Option Plan, as amended through
February 25, 2004
Table of Contents
*4.6
The ILEX Oncology, Inc. 1996 Non-Employee Director Stock Option
Plan, as amended through February 25, 2004
*4.7
The 2000 Employee Stock Compensation Plan, as amended through
February 25, 2004
*5.1
Opinion of Fulbright & Jaworski L.L.P. as to the legality of the
securities being registered
*23.1
Consent of Fulbright & Jaworski L.L.P. (included in exhibit 5.1)
*23.2
Consent of Ernst & Young LLP
*24.1
Powers of Attorney from the members of the Board of Directors of the
Registrant (contained on signature page hereof)
*
Filed herewith
Item 9.
Undertakings
The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement:
(i) To include any prospectus required by Section 10(a)(3) of the
Securities Act;
(ii) To reflect in the prospectus any facts or events arising after the
effective date of this Registration Statement (or the most recent
post-effective amendment hereof) which, individually or in the aggregate,
represent a fundamental change in the information set forth in this
Registration Statement; and
(iii) To include any material information with respect to the plan of
distribution not previously disclosed in this Registration Statement or any
material change to such information in this Registration Statement;
provided, however,
that paragraphs (i) and (ii) do not apply if the information
required to be included in a post-effective amendment by those paragraphs is
contained in periodic reports filed by the Registrant pursuant to Section 13 or
Section 15(d) of the Exchange Act that are incorporated by reference in this
Registration Statement.
(2) That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered herein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
(3) To remove from registration by means of a post-effective amendment any
of the securities being registered that remain unsold at the termination of the
offering.
The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act that is incorporated by reference in this Registration Statement
shall be deemed to be a new registration statement relating to the securities
offered herein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.
Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Commission such indemnification is
against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Registrant of expenses incurred or
paid by a director, officer or controlling
Table of Contents
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the
Securities Act and will be governed by the final adjudication of such issue.
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Antonio, State of Texas, on February 24, 2004.
ILEX ONCOLOGY, INC.
By:
/s/ Jeffrey H. Buchalter
Jeffrey H. Buchalter
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Ronald G. Tefteller and Mark P. Mellin,
his or her true and lawful agent, proxy and attorney-in-fact, each acting
alone, with full power of substitution and resubstitution, for him or her and
in his or her name, place and stead, in any and all capacities, to (i) act on,
sign and file with the SEC any and all amendments (including post-effective
amendments) to this Registration Statement filed pursuant to Rule 462(b) under
the Securities Act together with all schedules and exhibits thereto; (ii) act
on, sign and file such certificates, instruments, agreements and other
documents as may be necessary or appropriate in connection therewith; and (iii)
take any and all actions which may be necessary or appropriate to be done, as
fully for all intents and purposes as he or she might or could do in person,
hereby approving, ratifying and confirming all that such agent, proxy and
attorney-in-fact or any of his substitutes may lawfully do or cause to be done
by virtue thereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
SIGNATURE
TITLE
DATE
/s/ Joy A. Amundson
Joy A. Amundson
Chairman of the Board
February 25, 2004
/s/ Jeffrey H. Buchalter
Jeffrey H. Buchalter
President, Chief Executive Officer and Director
(principal executive officer)
February 24, 2004
/s/ Mark P. Mellin
Mark P. Mellin
Senior Vice President and Chief Financial Officer
(principal financial and accounting officer)
February 25, 2004
/s/ Joseph S. Bailes, M.D.
Joseph S. Bailes, M.D.
Director
February 24, 2004
/s/ Jason S. Fisherman, M.D.
Jason S. Fisherman, M.D.
Director
February 25, 2004
Table of Contents
SIGNATURE
TITLE
DATE
/s/ Richard L. Love
Richard L. Love
Director
February 24, 2004
/s/ Victor P. Micati
Victor P. Micati
Director
February 25, 2004
/s/ Daniel D. Von Hoff, M.D.
Daniel D. Von Hoff, M.D.
Director
February 25, 2004
/s/ Mark E. Watson, Jr.
Mark E. Watson, Jr.
Director
February 24, 2004
/s/ Gary V. Woods
Gary V. Woods
Director
February 24, 2004
Table of Contents
INDEX TO EXHIBITS
Exhibit
Number
Description of Exhibit
4.1
Amended and Restated Certificate of Incorporation of the
Company filed May 31, 2000 (Incorporated herein by reference to
Exhibit 3.1 of the Company's Quarterly Report on Form 10-Q
filed August 8, 2000)
4.2
Bylaws of the Company, as amended (Incorporated herein by
reference to Exhibit 3.2 of the Company's Registration
Statement No. 333-17769 on Form S-1 filed December 12, 1996, as
amended)
4.3
Specimen of certificate representing Common Stock, $.01 par
value, of the Company (Incorporated herein by reference to
Exhibit 4.1 of the Company's Registration Statement No.
333-17769 on Form S-1 filed December 12, 1996, as amended)
4.4
Rights Agreement dated April 10, 2001 by and between ILEX
Oncology, Inc. and American Stock Transfer & Trust Co. which
includes as Exhibit A the Form of Certificate of Designations
of Series I Preferred Stock, as Exhibit B the Form of Rights
Certificate and as Exhibit C the Summary of Rights to Purchase
Common Stock (Incorporated herein by reference to Exhibit 4.1
to the Company's Form 8-K filed April 11, 2001)
*4.5
The ILEX Oncology, Inc. 1995 Stock Option Plan, as amended
through February 25, 2004
*4.6
The ILEX Oncology, Inc. 1996 Non-Employee Director Stock Option
Plan, as amended through February 25, 2004
*4.7
The 2000 Employee Stock Compensation Plan, as amended through
February 25, 2004
*5.1
Opinion of Fulbright & Jaworski L.L.P. as to the legality of
the securities being registered
*23.1
Consent of Fulbright & Jaworski L.L.P. (included in exhibit 5.1)
*23.2
Consent of Ernst & Young LLP
*24.1
Powers of Attorney from the members of the Board of Directors
of the Registrant (contained on signature page hereof)
*
Filed herewith