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<P align="center" style="font-size: 10pt"><B>As filed with the Securities and Exchange Commission on March&nbsp;15, 2005</B>



<DIV align="right" style="font-size: 10pt"><B>Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></DIV>



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<DIV align="center" style="font-size: 14pt"><B>SECURITIES AND EXCHANGE COMMISSION</B>
</DIV>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>

<P align="center" style="font-size: 18pt"><B>FORM S-8</B>


<P align="center" style="font-size: 12pt"><B>REGISTRATION STATEMENT<BR>
Under<BR>
The Securities Act of 1933</B>

<P align="center" style="font-size: 24pt"><B>CYTRX CORPORATION</B>


<DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top"><B>Delaware</B><BR>
(State or other jurisdiction of<BR>
incorporation or organization)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>58-1642750</B><BR>
(IRS Employer Identification<BR>
No.)</TD>
</TR>
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</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><B>11726 San Vicente Boulevard, Suite&nbsp;650<BR>
Los Angeles, California 90049</B><BR>
(Address of principal executive offices, including zip code)



<P align="center" style="font-size: 10pt"><B>CytRx Corporation 2000 Long-Term Incentive Plan</B><BR>
(Full title of the plan)



<P align="center" style="font-size: 12pt"><B>Steven A. Kriegsman</B>

<DIV align="center" style="font-size: 10pt"><B>CytRx Corporation <BR>
11726 San Vicente Boulevard., Suite&nbsp;650<BR>
Los Angeles, California 90049<BR>
(310)&nbsp;826-5648</B><BR>
(Name, address and telephone, including area code, of agent for service of process)</DIV>



<P align="center" style="font-size: 10pt"><B>Copy to:</B>


<DIV align="center" style="font-size: 12pt"><B>Sanford J. Hillsberg, Esq.</B></DIV>



<DIV align="center" style="font-size: 10pt"><B>Troy &#038; Gould Professional Corporation<BR>
1801 Century Park East, Suite&nbsp;1600, Los Angeles, California 90067<BR>
(310)&nbsp;553-4441</B></DIV>



<P align="center" style="font-size: 12pt"><B>CALCULATION OF REGISTRATION FEE</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="60%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
</TR>
<TR style="font-size: 1px">
    <TD colspan="17" align="left" style="border-top: 3px double #000000">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left">Title of each class of</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2">Amount to be</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2">Proposed maximum</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2">Proposed maximum</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2">Amount of</TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left">securities to be registered</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2">registered <SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2">offering price per share</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2">aggregate offering price</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="2">registration fee</TD>
    <TD>&nbsp;</TD>
</TR>

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<TR style="font-size: 1px">
    <TD colspan="17" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par value
$.001 per share
<SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP> </DIV></TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan="3" align="center">1,565,667&nbsp;shares <SUP style="font-size: 85%; vertical-align: text-top">(3)</SUP></TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan="3" align="center">$1.63 <SUP style="font-size: 85%; vertical-align: text-top">(3)</SUP></TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan="3" align="center">$2,552,038 <SUP style="font-size: 85%; vertical-align: text-top">(3)</SUP></TD>
    <TD>&nbsp;</TD>
    <TD align="left">$</TD>
    <TD align="right">301</TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 1px">
    <TD colspan="17" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">Common Stock, par value
$.001 per share
<SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></DIV></TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan="3" align="center">5,434,333&nbsp;shares <SUP style="font-size: 85%; vertical-align: text-top">(4)</SUP></TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan="3" align="center">$1.25 <SUP style="font-size: 85%; vertical-align: text-top">(4)</SUP></TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan="3" align="center">$6,792,917 <SUP style="font-size: 85%; vertical-align: text-top">(4)</SUP></TD>
    <TD>&nbsp;</TD>
    <TD align="left">$</TD>
    <TD align="right">799</TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 1px">
    <TD colspan="17" align="left" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">Total</DIV></TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="center">7,000,000 shares</TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan="3" align="center">&#151;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan="3" align="center">$9,394,955&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left">$</TD>
    <TD align="right">1,100</TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 1px">
    <TD colspan="17" align="left" style="border-top: 3px double #000000">&nbsp;</TD>
</TR>
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</TABLE>
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<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="3%">&nbsp;</TD>
    <TD width="1%" nowrap align="left">(1)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="93%">Pursuant to Rule 416(a) of the Securities Act of 1933, this Registration Statement also
covers such additional shares of common stock as may become issuable under the CytRx
Corporation 2000 Long-Term Incentive Plan (the &#147;Plan&#148;) as a result of the anti-dilution
adjustment provisions of the Plan.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%">&nbsp;</TD>
    <TD width="1%" nowrap align="left">(2)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="93%">Includes a Series&nbsp;A Junior Participating Preferred Stock Purchase Right associated with
each share. Prior to the occurrence of certain events, such rights will not be evidenced
or traded separately from the Registrant&#146;s common stock. The value, if any, of the rights
is reflected in the market price of the Registrant&#146;s common stock. Accordingly, no
separate registration fee is payable with respect to the rights.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%">&nbsp;</TD>
    <TD width="1%" nowrap align="left">(3)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="93%">Represents shares issuable upon the exercise of outstanding options under the Plan.
The proposed maximum offering price per share and maximum aggregate offering price for
these shares were estimated pursuant to Rule 457(h) of the Securities Act on the basis of
the weighted-average exercise price of such options of $1.63 per share.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%">&nbsp;</TD>
    <TD width="1%" nowrap align="left">(4)</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="93%">Represents shares reserved for issuance pursuant to future awards under the Plan. The
proposed maximum offering price per share and maximum aggregate offering price for these
shares were estimated pursuant to Rule 457(c) of the Securities Act of 1933 on the basis of
the $1.25 average of the high and low trading prices of Registrant&#146;s common stock
reported on the NASDAQ SmallCap Market on March&nbsp;10, 2005.</TD>
</TR>

</TABLE>



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<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD colspan="9"><A HREF="#000">PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;3. Incorporation of Documents by Reference.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;5. Interest of Named Experts and Counsel.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;8. Exhibits.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#004">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#005">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="v06874exv5.htm">Exhibit 5</A></TD></TR>
<TR><TD colspan="9"><A HREF="v06874exv23w2.htm">Exhibit 23.2</A></TD></TR>
<TR><TD colspan="9"><A HREF="v06874exv23w3.htm">Exhibit 23.3</A></TD></TR>
<TR><TD colspan="9"><A HREF="v06874exv23w4.htm">Exhibit 23.4</A></TD></TR>
<TR><TD colspan="9"><A HREF="v06874exv23w5.htm">Exhibit 23.5</A></TD></TR>
<TR><TD colspan="9"><A HREF="v06874exv23w6.htm">Exhibit 23.6</A></TD></TR>
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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>





<P align="left" style="font-size: 10pt"><B>Registration of Additional Securities</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CytRx Corporation (the &#147;Company&#148;) is filing this registration statement on Form S-8 pursuant
to General Instruction E to Form S-8 to register 7,000,000 additional shares of the Company&#146;s
Common Stock, par value $.001 per share, authorized for issuance pursuant to outstanding options or
future awards granted under the CytRx Corporation 2000 Long-Term Incentive Plan. The contents of
the Company&#146;s original registration statement on Form S-8 filed with the Securities and Exchange
Commission (the &#147;Commission&#148;) on August&nbsp;23, 2001 in connection with such plan (File No.&nbsp;333-68200)
and its subsequent registration statement on Form S-8 filed with the Commission on July&nbsp;16, 2002 to
register additional securities in connection with such plan (File No.&nbsp;333-93305) are hereby
incorporated by reference.

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<DIV align="left"><A NAME="000"></A></DIV>

<P align="center" style="font-size: 10pt"><B>PART II</B>



<P align="center" style="font-size: 10pt"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>


<!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference." -->
<DIV align="left"><A NAME="001"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;3. Incorporation of Documents by Reference.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents have been filed by the Company with the Securities and Exchange
Commission under the Securities Exchange Act of 1934, as amended (the &#147;Exchange Act&#148;), and are
incorporated in this Registration Statement by reference:


<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" style="background: transparent">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD width="4%" nowrap align="left">a.&nbsp;&nbsp;</TD>
    <TD>The Company&#146;s Annual Report on Form 10-K for the fiscal year ended December&nbsp;31,
2003;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" style="background: transparent">&nbsp;</TD>
    <TD width="4%" nowrap align="left">b.&nbsp;&nbsp;</TD>
    <TD>The Company&#146;s Quarterly Reports on Form 10-Q for the quarters ended March&nbsp;31,
June&nbsp;30 and September&nbsp;30, 2004, respectively;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" style="background: transparent">&nbsp;</TD>
    <TD width="4%" nowrap align="left">c.&nbsp;&nbsp;</TD>
    <TD>All other reports filed by the Company pursuant to Section 13(a) or 15(d) of
the Exchange Act since December&nbsp;31, 2003;</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" style="background: transparent">&nbsp;</TD>
    <TD width="4%" nowrap align="left">d.&nbsp;&nbsp;</TD>
    <TD>The Company&#146;s registration statement on Form S-8 filed with the Commission on
August&nbsp;23, 2001 (File No.&nbsp;333-68200) and its subsequent registration statement on Form
S-8 filed with the Commission on July&nbsp;16, 2002 (File No.&nbsp;333-93305); and</TD>
</TR>

<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" style="background: transparent">&nbsp;</TD>
    <TD width="4%" nowrap align="left">e.&nbsp;&nbsp;</TD>
    <TD>The description of the Common Stock contained in the Company&#146;s registration
statement filed under Section&nbsp;12 of the Exchange Act, including all amendments or
reports filed for the purpose of updating such description.</TD>
</TR>

</TABLE>


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In addition, all documents filed by the Company pursuant to Sections&nbsp;13(a), 13(c), 14 and
15(d) of the Exchange Act, subsequent to the date of this Registration Statement and prior to the
filing of a post-effective amendment indicating that all securities offered pursuant to this
Registration Statement have been sold or deregistering all such securities then remaining unsold,
shall be deemed to be incorporated by reference herein and to be part hereof from the date of
filing of such documents.

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<DIV align="left"><A NAME="002"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;5. Interest of Named Experts and Counsel.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The validity of the shares being registered hereby has been passed upon by Troy &#038; Gould
Professional Corporation. As of the date of its opinion, that firm owned 100,000 shares of common
stock of the Company and warrants to purchase 6,250 shares of common stock.


<P align="center" style="font-size: 10pt">2
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">
<!-- link2 "Item&nbsp;8. Exhibits." -->
<DIV align="left"><A NAME="003"></A></DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;8. Exhibits.</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="85%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="5%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="80%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit No.</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit Description</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Corrected Restated Certificate of Incorporation
(incorporated by reference from Exhibit&nbsp;3.1 to the
Company&#146;s registration statement on Form&nbsp;S-8 filed on
June&nbsp;24, 2002, File No.&nbsp;333-91068).</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Restated By-Laws, as amended (incorporated by
reference from Exhibit&nbsp;4.2 to the Company&#146;s
registration statement on Form&nbsp;S-8 filed on July&nbsp;21,
1997, File No.&nbsp;333-37171).</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">CytRx Corporation 2000 Long-Term Incentive Plan
(incorporated by reference from Exhibit&nbsp;10.11 to the
Company&#146;s Form&nbsp;10-K for the fiscal year ended December
31, 2000 filed on March&nbsp;27, 2001), as amended by
Amendments No.&nbsp;1 and 2 dated February&nbsp;8, 2002 and
March&nbsp;1, 2002 respectively (incorporated by reference
from Exhibits 10.12 and 10.13 to the Company&#146;s Form
10-K for the fiscal year ended December&nbsp;31, 2001 filed
on April&nbsp;1, 2002), and Amendments No.&nbsp;3 and 4 each
dated September&nbsp;4, 2003 (incorporated by reference
from Appendix&nbsp;B and C to the Company&#146;s Proxy Statement
filed on September&nbsp;17, 2003).</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Troy &#038; Gould Professional Corporation*</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Troy &#038; Gould Professional Corporation
(included in Exhibit&nbsp;5)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of BDO Seidman, LLP*</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP*</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.4
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of BDO Seidman, LLP*</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.5
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Silverman Olson Thorvilson &#038; Kaufmann, Ltd.*</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.6
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP*</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<P>
<HR size="1" width="18%" align="left" noshade color="#000000">

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="1%" nowrap align="left">*</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Included herewith.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt">3
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">





<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="004"></A></DIV>

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Company certifies that it has
reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Los Angeles, California, on this 15th day of March, 2005.


<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left"><B>CYTRX CORPORATION</B><BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" style="border-bottom: 1px solid #000000" align="left">/s/ Steven A. Kriegsman
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">Steven A. Kriegsman&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">Chief Executive Officer and President&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>

<P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>




<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below hereby constitutes and appoints Steven A. Kriegsman
such person&#146;s true and lawful attorney-in-fact and agent, with full power of substitution and
resubstitution, to sign on such person&#146;s behalf, individually and in each capacity stated below,
all amendments and post-effective amendments to this Registration Statement on Form S-8 and to file
the same, with all exhibits thereto and any other documents in connection therewith, with the
Commission under the Securities Act, granting unto said attorney-in-fact and agent full power and
authority to do and perform each and every act and thing requisite and necessary to be done in and
about the premises, as fully and to all intents and purposes as he might or could do in person,
hereby ratifying and confirming each act that said attorney-in-fact and agent may lawfully do or
cause to be done by virtue thereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, this Registration Statement has been
signed by the following persons in the capacities and on the dates indicated.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="35%">&nbsp;</TD>
    <TD width="8%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000"><B>Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" style="border-bottom: 1px solid #000000"><B>Date</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
    <TD align="left" nowrap valign="top">/s/ Steven A. Kriegsman
<HR size="1" noshade color="#000000">
Steven A. Kriegsman</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Chief Executive Officer,
President and Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Matthew Natalizio
<HR size="1" noshade color="#000000">
Matthew Natalizio</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Chief Financial Officer
(Principal Financial and
Accounting Officer)
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Louis J. Ignarro
<HR size="1" noshade color="#000000">
Louis J. Ignarro</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Joseph Rubinfeld, Ph.D.
<HR size="1" noshade color="#000000">
Joseph Rubinfeld, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Max Link
<HR size="1" noshade color="#000000">
Max Link</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Richard L. Wennekamp
<HR size="1" noshade color="#000000">
Richard L. Wennekamp</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<TR valign="bottom" style="padding-top: 1em">
    <TD align="left" nowrap valign="top">/s/ Marvin R. Selter
<HR size="1" noshade color="#000000">
Marvin R. Selter</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">
Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">March 15, 2005</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt">4
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">

<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="005"></A></DIV>

<P align="center" style="font-size: 10pt"><U><B>EXHIBIT INDEX</B></U>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="5%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="80%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit No.</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="left" style="border-bottom: 1px solid #000000">Exhibit Description</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Corrected Restated Certificate of Incorporation
(incorporated by reference from Exhibit&nbsp;3.1 to the
Company&#146;s registration statement on Form&nbsp;S-8 filed on
June&nbsp;24, 2002, File Number 333-91068).</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Restated By-Laws, as amended (incorporated by
reference from Exhibit&nbsp;4.2 to the Company&#146;s
registration statement on Form&nbsp;S-8 filed on July&nbsp;21,
1997, File Number 333-37171).</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">4.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">CytRx Corporation 2000 Long-Term Incentive Plan
(incorporated by reference from Exhibit&nbsp;10.11 to the
Company&#146;s Form&nbsp;10-K for the fiscal year ended December
31, 2000 filed on March&nbsp;27, 2001), as amended by
Amendments No.&nbsp;1 and 2 dated February&nbsp;8, 2002 and
March&nbsp;1, 2002 respectively (incorporated by reference
from Exhibits 10.12 and 10.13 to the Company&#146;s Form
10-K for the fiscal year ended December&nbsp;31, 2001 filed
on April&nbsp;1, 2002), and Amendments No.&nbsp;3 and 4 each
dated September&nbsp;4, 2003 (incorporated by reference
from Appendix&nbsp;B and C to the Company&#146;s Proxy Statement
filed on September&nbsp;17, 2003).</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Troy &#038; Gould Professional Corporation*</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Troy &#038; Gould Professional Corporation
(included in Exhibit&nbsp;5)</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of BDO Seidman, LLP*</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.3
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP*</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.4
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of BDO Seidman, LLP*</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.5
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Silverman Olson Thorvilson &#038; Kaufmann, Ltd.*</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.6
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Ernst &#038; Young LLP*</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<P>
<HR size="1" width="18%" align="left" noshade color="#000000">

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="1%" nowrap align="left">*</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="96%">Included herewith.</TD>
</TR>

</TABLE>


<P align="center" style="font-size: 10pt">5
</DIV>

</BODY>
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sv8
Table of Contents
As filed with the Securities and Exchange Commission on March 15, 2005
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
CYTRX CORPORATION
(Exact name of registrant as specified in its charter)
Delaware
(State or other jurisdiction of
incorporation or organization)
58-1642750
(IRS Employer Identification
No.)
11726 San Vicente Boulevard, Suite 650
Los Angeles, California 90049
(Address of principal executive offices, including zip code)
CytRx Corporation 2000 Long-Term Incentive Plan
(Full title of the plan)
Steven A. Kriegsman
CytRx Corporation
11726 San Vicente Boulevard., Suite 650
Los Angeles, California 90049
(310) 826-5648
(Name, address and telephone, including area code, of agent for service of process)
Copy to:
Sanford J. Hillsberg, Esq.
Troy & Gould Professional Corporation
1801 Century Park East, Suite 1600, Los Angeles, California 90067
(310) 553-4441
CALCULATION OF REGISTRATION FEE
Title of each class of
Amount to be
Proposed maximum
Proposed maximum
Amount of
securities to be registered
registered
(1)
offering price per share
aggregate offering price
registration fee
Common Stock, par value
$.001 per share
(2)
1,565,667 shares
(3)
$1.63
(3)
$2,552,038
(3)
$
301
Common Stock, par value
$.001 per share
(2)
5,434,333 shares
(4)
$1.25
(4)
$6,792,917
(4)
$
799
Total
7,000,000 shares
—
$9,394,955
$
1,100
(1)
Pursuant to Rule 416(a) of the Securities Act of 1933, this Registration Statement also
covers such additional shares of common stock as may become issuable under the CytRx
Corporation 2000 Long-Term Incentive Plan (the "Plan") as a result of the anti-dilution
adjustment provisions of the Plan.
(2)
Includes a Series A Junior Participating Preferred Stock Purchase Right associated with
each share. Prior to the occurrence of certain events, such rights will not be evidenced
or traded separately from the Registrant's common stock. The value, if any, of the rights
is reflected in the market price of the Registrant's common stock. Accordingly, no
separate registration fee is payable with respect to the rights.
(3)
Represents shares issuable upon the exercise of outstanding options under the Plan.
The proposed maximum offering price per share and maximum aggregate offering price for
these shares were estimated pursuant to Rule 457(h) of the Securities Act on the basis of
the weighted-average exercise price of such options of $1.63 per share.
(4)
Represents shares reserved for issuance pursuant to future awards under the Plan. The
proposed maximum offering price per share and maximum aggregate offering price for these
shares were estimated pursuant to Rule 457(c) of the Securities Act of 1933 on the basis of
the $1.25 average of the high and low trading prices of Registrant's common stock
reported on the NASDAQ SmallCap Market on March 10, 2005.
TABLE OF CONTENTS
PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
Item 5. Interest of Named Experts and Counsel.
Item 8. Exhibits.
SIGNATURES
EXHIBIT INDEX
Exhibit 5
Exhibit 23.2
Exhibit 23.3
Exhibit 23.4
Exhibit 23.5
Exhibit 23.6
Table of Contents
Registration of Additional Securities
CytRx Corporation (the "Company") is filing this registration statement on Form S-8 pursuant
to General Instruction E to Form S-8 to register 7,000,000 additional shares of the Company's
Common Stock, par value $.001 per share, authorized for issuance pursuant to outstanding options or
future awards granted under the CytRx Corporation 2000 Long-Term Incentive Plan. The contents of
the Company's original registration statement on Form S-8 filed with the Securities and Exchange
Commission (the "Commission") on August 23, 2001 in connection with such plan (File No. 333-68200)
and its subsequent registration statement on Form S-8 filed with the Commission on July 16, 2002 to
register additional securities in connection with such plan (File No. 333-93305) are hereby
incorporated by reference.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents have been filed by the Company with the Securities and Exchange
Commission under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and are
incorporated in this Registration Statement by reference:
a.
The Company's Annual Report on Form 10-K for the fiscal year ended December 31,
2003;
b.
The Company's Quarterly Reports on Form 10-Q for the quarters ended March 31,
June 30 and September 30, 2004, respectively;
c.
All other reports filed by the Company pursuant to Section 13(a) or 15(d) of
the Exchange Act since December 31, 2003;
d.
The Company's registration statement on Form S-8 filed with the Commission on
August 23, 2001 (File No. 333-68200) and its subsequent registration statement on Form
S-8 filed with the Commission on July 16, 2002 (File No. 333-93305); and
e.
The description of the Common Stock contained in the Company's registration
statement filed under Section 12 of the Exchange Act, including all amendments or
reports filed for the purpose of updating such description.
In addition, all documents filed by the Company pursuant to Sections 13(a), 13(c), 14 and
15(d) of the Exchange Act, subsequent to the date of this Registration Statement and prior to the
filing of a post-effective amendment indicating that all securities offered pursuant to this
Registration Statement have been sold or deregistering all such securities then remaining unsold,
shall be deemed to be incorporated by reference herein and to be part hereof from the date of
filing of such documents.
Item 5. Interest of Named Experts and Counsel.
The validity of the shares being registered hereby has been passed upon by Troy & Gould
Professional Corporation. As of the date of its opinion, that firm owned 100,000 shares of common
stock of the Company and warrants to purchase 6,250 shares of common stock.
2
Table of Contents
Item 8. Exhibits.
Exhibit No.
Exhibit Description
4.1
Corrected Restated Certificate of Incorporation
(incorporated by reference from Exhibit 3.1 to the
Company's registration statement on Form S-8 filed on
June 24, 2002, File No. 333-91068).
4.2
Restated By-Laws, as amended (incorporated by
reference from Exhibit 4.2 to the Company's
registration statement on Form S-8 filed on July 21,
1997, File No. 333-37171).
4.3
CytRx Corporation 2000 Long-Term Incentive Plan
(incorporated by reference from Exhibit 10.11 to the
Company's Form 10-K for the fiscal year ended December
31, 2000 filed on March 27, 2001), as amended by
Amendments No. 1 and 2 dated February 8, 2002 and
March 1, 2002 respectively (incorporated by reference
from Exhibits 10.12 and 10.13 to the Company's Form
10-K for the fiscal year ended December 31, 2001 filed
on April 1, 2002), and Amendments No. 3 and 4 each
dated September 4, 2003 (incorporated by reference
from Appendix B and C to the Company's Proxy Statement
filed on September 17, 2003).
5
Opinion of Troy & Gould Professional Corporation*
23.1
Consent of Troy & Gould Professional Corporation
(included in Exhibit 5)
23.2
Consent of BDO Seidman, LLP*
23.3
Consent of Ernst & Young LLP*
23.4
Consent of BDO Seidman, LLP*
23.5
Consent of Silverman Olson Thorvilson & Kaufmann, Ltd.*
23.6
Consent of Ernst & Young LLP*
*
Included herewith.
3
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Company certifies that it has
reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Los Angeles, California, on this 15th day of March, 2005.
CYTRX CORPORATION
By:
/s/ Steven A. Kriegsman
Steven A. Kriegsman
Chief Executive Officer and President
POWER OF ATTORNEY
Each person whose signature appears below hereby constitutes and appoints Steven A. Kriegsman
such person's true and lawful attorney-in-fact and agent, with full power of substitution and
resubstitution, to sign on such person's behalf, individually and in each capacity stated below,
all amendments and post-effective amendments to this Registration Statement on Form S-8 and to file
the same, with all exhibits thereto and any other documents in connection therewith, with the
Commission under the Securities Act, granting unto said attorney-in-fact and agent full power and
authority to do and perform each and every act and thing requisite and necessary to be done in and
about the premises, as fully and to all intents and purposes as he might or could do in person,
hereby ratifying and confirming each act that said attorney-in-fact and agent may lawfully do or
cause to be done by virtue thereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been
signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Steven A. Kriegsman
Steven A. Kriegsman
Chief Executive Officer,
President and Director
March 15, 2005
/s/ Matthew Natalizio
Matthew Natalizio
Chief Financial Officer
(Principal Financial and
Accounting Officer)
March 15, 2005
/s/ Louis J. Ignarro
Louis J. Ignarro
Director
March 15, 2005
/s/ Joseph Rubinfeld, Ph.D.
Joseph Rubinfeld, Ph.D.
Director
March 15, 2005
/s/ Max Link
Max Link
Director
March 15, 2005
/s/ Richard L. Wennekamp
Richard L. Wennekamp
Director
March 15, 2005
/s/ Marvin R. Selter
Marvin R. Selter
Director
March 15, 2005
4
Table of Contents
EXHIBIT INDEX
Exhibit No.
Exhibit Description
4.1
Corrected Restated Certificate of Incorporation
(incorporated by reference from Exhibit 3.1 to the
Company's registration statement on Form S-8 filed on
June 24, 2002, File Number 333-91068).
4.2
Restated By-Laws, as amended (incorporated by
reference from Exhibit 4.2 to the Company's
registration statement on Form S-8 filed on July 21,
1997, File Number 333-37171).
4.3
CytRx Corporation 2000 Long-Term Incentive Plan
(incorporated by reference from Exhibit 10.11 to the
Company's Form 10-K for the fiscal year ended December
31, 2000 filed on March 27, 2001), as amended by
Amendments No. 1 and 2 dated February 8, 2002 and
March 1, 2002 respectively (incorporated by reference
from Exhibits 10.12 and 10.13 to the Company's Form
10-K for the fiscal year ended December 31, 2001 filed
on April 1, 2002), and Amendments No. 3 and 4 each
dated September 4, 2003 (incorporated by reference
from Appendix B and C to the Company's Proxy Statement
filed on September 17, 2003).
5
Opinion of Troy & Gould Professional Corporation*
23.1
Consent of Troy & Gould Professional Corporation
(included in Exhibit 5)
23.2
Consent of BDO Seidman, LLP*
23.3
Consent of Ernst & Young LLP*
23.4
Consent of BDO Seidman, LLP*
23.5
Consent of Silverman Olson Thorvilson & Kaufmann, Ltd.*
23.6
Consent of Ernst & Young LLP*
*
Included herewith.
5