<PAGE>

      AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JUNE 16, 2000
                                                     REGISTRATION NO. 333-


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                              --------------------

                                    FORM S-8
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                              ---------------------

                          CRYO-CELL INTERNATIONAL, INC.
             (Exact name of registrant as specified in its charter)

                              ---------------------

          DELAWARE                                     22-302-3093
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
 incorporation or organization)

                              ---------------------

                      3165 McMullen Booth Road, Building #B
                              Clearwater, FL 33761
                                 (727) 723-0333
    (Address of Registrant's principal executive offices, including zip code)

                             ---------------------

                            ADVISOR COMPENSATION PLAN
                            (Full title of the Plan)

                     Daniel Richard, Chief Executive Officer
                      3165 McMullen Booth Road, Building #5
                              Clearwater, FL 33761
                                 (727) 723-0333
            (Name, address and telephone number of agent for service)

                              ---------------------

                Approximate Date of Proposed Sale to the Public:
   As soon as practicable after this Registration Statement becomes effective.

                              --------------------

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
===================================================================================================================
        Title of Securities            Amount to be      Proposed Maximum    Proposed Maximum       Amount of
         to be Registered               Registered      Offering Price per  Aggregate Offering   Registration Fee
                                                               Share               Price
===================================================================================================================
<S>                                      <C>                  <C>                 <C>                  <C>
  Common Stock, $0.01 Par Value(1)       20,000(1)            $6.75(2)            $135,000             $40.90
===================================================================================================================
</TABLE>

-------------------
1    Includes 20,000 shares of common stock, issuable for counseling and
     advisory services to Coleman Sudol.

2    Estimated solely for purposes of calculating the amount of the registration
     fee pursuant to Rule 457(c) of the Securities Act of 1933, based on the
     average of the high and low sales prices of a share of Common Stock of the
     Company on the NASDAQ National Market System on June 12, 2000.


<PAGE>


                                     PART II

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

         The following documents previously filed by CRYO-CELL International,
Inc., a Delaware corporation (the "Company") with the Securities and Exchange
Commission (the "Commission") are incorporated into this registration statement
by reference.

     1.   The Company's Annual Report on Form 10-KSB for the fiscal year ended
          November 30, 1999, filed with the Commission on February 29, 2000.

     2.   The description of the Company's Common Stock is contained in its
          Registration Statement on Form 8A dated February 4, 1994, filed
          pursuant to Section 12 of the Securities Exchange Act of 1934.

         In addition, all reports and other documents that we subsequently file
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act
of 1934, prior to the filing of a post-effective amendment which indicates that
all securities offered have been sold or which deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference in, and to be
a part of, this registration statement from the date of filing of such documents
(such documents, and the documents enumerated above, being referred to in this
registration statement as "Incorporated Documents").

         To the extent information contained in this registration statement or
any Incorporated Document differs from information contained in an earlier-filed
Incorporated Document, rely on the different information in this registration
statement or the later-filed Incorporated Document.

ITEM 4.  DESCRIPTION OF SECURITIES.

         The class of securities covered by this Registration Statement is
registered under Section 12(g) of the Securities Exchange Act of 1934, as
amended.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

         The securities covered by this Registration Statement are issuable to
attorneys at Coleman Sudol for legal counseling and advisory services.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         The Company's Bylaws and the Delaware General Corporation Law provide
for indemnification of directors and officers against certain liabilities.
Officers and directors of the Company are indemnified generally against expenses
actually and reasonably incurred in connection with proceedings, whether civil
or criminal, provided that it is determined that they acted in good faith, were
not found guilty, and, in any criminal matter, had reasonable cause to believe
that their conduct was not unlawful.

         The Company's Certificate of Incorporation further provides that a
director of the Company shall not be personally liable for monetary damages to
the Company or its shareholders for breach of any fiduciary duty as a director,
except for liability (i) for any breach of the director's duty of loyalty to the
Company or its stockholders; (ii) for acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law; (iii) for
the unlawful payments of dividends or stock redemption by the company or (iv)
for any transaction from which the director derives an improper personal
benefit.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

         Not applicable.

ITEM 8.  EXHIBITS.
         The exhibits required by Item 601 of Regulation S-K are listed in the
Exhibit Index hereto.

                                       2

<PAGE>

ITEM 9.  UNDERTAKINGS.

(a)  The undersigned Company hereby undertakes:

     1)   To file, during any period in which offers or sales are being made, a
          post-effective amendment to this registration statement:


          (i)  To include any prospectus required by Section 10(a)(3) of the
               Securities Act of 1933 (the "Securities Act");

          (ii) To reflect in the prospectus any facts or events arising after
               the effective date of this registration statement (or the most
               recent post-effective amendment thereof) which, individually or
               in the aggregate, represent a fundamental change in the
               information set forth in this registration statement.
               Notwithstanding the foregoing, any increase or decrease in the
               volume of securities offered (if the total dollar value of
               securities offered would not exceed that which was registered)
               and any deviation from the low or high end of the estimated
               maximum offering range may be reflected in the form of prospectus
               filed with the Commission pursuant to Rule 424(b) if, in the
               aggregate, the changes in volume and price represent no more than
               20 percent change in the maximum aggregate offering price set
               forth in the "Calculation of Registration Fee" table in the
               effective registration statement; and

         (iii) To include any material information with respect to the plan of
               distribution not previously disclosed in this registration
               statement or any material change to such information in this
               registration statement; provided, however, that paragraphs
               (a)(1)(i) and (a)(l)(ii) do not apply if the information required
               to be included in a post-effective amendment by those paragraphs
               is contained in periodic reports filed by the Company pursuant to
               Section 13 or Section 15(d) of the Exchange Act that are
               incorporated by reference in this registration statement.

     2)   That, for the purpose of determining any liability under the
          Securities Act, each such post-effective amendment shall be deemed to
          be a new registration statement relating to the securities offered
          therein, and the offering of such securities at that time shall be
          deemed to be the initial bona fide offering thereof.

     3)   To remove from registration by means of a post-effective amendment any
          of the securities being registered which remain unsold at the
          termination of the offering.

(b) The undersigned Company hereby undertakes that, for purposes of determining
any liability under the Securities Act, each filing of the Company's annual
report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and,
where applicable, each filing of an employee benefit plan's annual report
pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference
in this registration statement shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering
thereof.

(c) Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the Company
pursuant to the foregoing provisions, or otherwise, the Company has been advised
that in the opinion of the Commission such indemnification is against public
policy as expressed in the Securities Act and is, therefore, unenforceable. In
the event that a claim for indemnification against such liabilities (other than
the payment by the Company of expenses incurred or paid by a director, officer
or controlling person of the Company in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling person
in connection with the securities being registered, the Company will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.


                                       3
<PAGE>

                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the Company
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized in the City of Clearwater, State of Florida on June 13, 2000.

                                       CRYO-CELL INTERNATIONAL, INC.

                                       By: /s/ Daniel D. Richard
                                           ---------------------------
                                       Daniel D. Richard
                                       Chief Executive Officer


                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below hereby constitutes and appoints Daniel D. Richard and each of
them, his true and lawful attorney-in-fact and agent, each with full power of
substitution and revocation, for him and in his name, place and stead, in any
and all capacities, to sign any and all amendments (including post-effective
amendments) to this registration statement, and to file the same with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto each such attorney-in-fact and
agent, full power and authority to do and perform each and every act and thing
requisite and necessary to be done, as fully to all intents and purposes as such
person might or could do in person, hereby ratifying and confirming all that
said attorney-in-fact and agent or his substitute or substitutes, may lawfully
do or cause to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
registration statement and the foregoing power of attorney have been signed by
the following persons in the capacities and on the dates indicated:

<TABLE>
<CAPTION>

NAME                                    TITLE                                            DATE
----                                    -----                                            ----

<S>                                     <C>                                             <C>
/s/ Daniel D.Richard                    Chief Executive Officer and                     June 13, 2000
--------------------                    Chairman of the Board
Daniel D. Richard                       (Principal Executive Officer)

/s/ Wanda D. Dearth                     President and Chief Operating Officer           June 13, 2000
-------------------
Wanda D. Dearth

/s/ Gerald F. Maass                     Vice President and General                      June 13, 2000
-------------------                     Manager, Director
Gerald F. Maass

/s/ Jill M. Taymans                     Chief Financial Officer                         June 13, 2000
-------------------
Jill M. Taymans

/s/ Edward Modzelewski                  Director                                        June 13, 2000
----------------------
Edward Modzelewski

/s/ Frederick C.S. Wilhelm              Director                                        June 13, 2000
--------------------------
Frederick CS Wilhelm

</TABLE>


                                       4

<PAGE>



                                  EXHIBIT INDEX

<TABLE>
<CAPTION>

EXHIBIT                                    DESCRIPTION OF EXHIBIT
NUMBER                                     ----------------------
-------
<S>               <C>
4.1              Retainer Agreement with Coleman Sudol

5.1              Opinion of Thaddeus Freeman as to the legality of the securities being registered.

23.1             Consent of Thaddeus Freeman (included in its opinion filed as Exhibit 5.1).

23.2             Consent of Weinick Sanders Leventhal & Co.

24               Power of Attorney (included with the signature page to this registration statement).

</TABLE>


                                       5
[{"type": "S-8", "sequence": "1", "filename": "s-8.txt", "description": "FORM S-8", "secsgml_size_bytes": 15271}]
{"company-data": {"conformed-name": "CRYO CELL INTERNATIONAL INC", "cik": "0000862692", "assigned-sic": "8900", "irs-number": "223023093", "state-of-incorporation": "DE", "fiscal-year-end": "1130"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-39550", "film-number": "656703"}, "business-address": {"street1": "3165 MCMULLEN BOOTH RD", "street2": "BLDG B", "city": "CLEARWATER", "state": "FL", "zip": "33761", "phone": "7277230333"}, "mail-address": {"street1": "3165 MCMULLEN BOOTH RD", "street2": "BLDG. B", "city": "CLEARWATER", "state": "FL", "zip": "33761"}}
AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JUNE 16, 2000
                                                     REGISTRATION NO. 333-

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                              --------------------

                                    FORM S-8
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                              ---------------------

                          CRYO-CELL INTERNATIONAL, INC.
             (Exact name of registrant as specified in its charter)

                              ---------------------

          DELAWARE                                     22-302-3093
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
 incorporation or organization)

                              ---------------------

                      3165 McMullen Booth Road, Building #B
                              Clearwater, FL 33761
                                 (727) 723-0333
    (Address of Registrant's principal executive offices, including zip code)

                             ---------------------

                            ADVISOR COMPENSATION PLAN
                            (Full title of the Plan)

                     Daniel Richard, Chief Executive Officer
                      3165 McMullen Booth Road, Building #5
                              Clearwater, FL 33761
                                 (727) 723-0333
            (Name, address and telephone number of agent for service)

                              ---------------------

                Approximate Date of Proposed Sale to the Public:
   As soon as practicable after this Registration Statement becomes effective.

                              --------------------

                         CALCULATION OF REGISTRATION FEE
===================================================================================================================
        Title of Securities            Amount to be      Proposed Maximum    Proposed Maximum       Amount of
         to be Registered               Registered      Offering Price per  Aggregate Offering   Registration Fee
                                                               Share               Price
===================================================================================================================
Common Stock, $0.01 Par Value(1)       20,000(1)            $6.75(2)            $135,000             $40.90
===================================================================================================================
-------------------
1    Includes 20,000 shares of common stock, issuable for counseling and
     advisory services to Coleman Sudol.

2    Estimated solely for purposes of calculating the amount of the registration
     fee pursuant to Rule 457(c) of the Securities Act of 1933, based on the
     average of the high and low sales prices of a share of Common Stock of the
     Company on the NASDAQ National Market System on June 12, 2000.
PART II

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

         The following documents previously filed by CRYO-CELL International,
Inc., a Delaware corporation (the "Company") with the Securities and Exchange
Commission (the "Commission") are incorporated into this registration statement
by reference.

     1.   The Company's Annual Report on Form 10-KSB for the fiscal year ended
          November 30, 1999, filed with the Commission on February 29, 2000.

     2.   The description of the Company's Common Stock is contained in its
          Registration Statement on Form 8A dated February 4, 1994, filed
          pursuant to Section 12 of the Securities Exchange Act of 1934.

         In addition, all reports and other documents that we subsequently file
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act
of 1934, prior to the filing of a post-effective amendment which indicates that
all securities offered have been sold or which deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference in, and to be
a part of, this registration statement from the date of filing of such documents
(such documents, and the documents enumerated above, being referred to in this
registration statement as "Incorporated Documents").

         To the extent information contained in this registration statement or
any Incorporated Document differs from information contained in an earlier-filed
Incorporated Document, rely on the different information in this registration
statement or the later-filed Incorporated Document.

ITEM 4.  DESCRIPTION OF SECURITIES.

         The class of securities covered by this Registration Statement is
registered under Section 12(g) of the Securities Exchange Act of 1934, as
amended.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

         The securities covered by this Registration Statement are issuable to
attorneys at Coleman Sudol for legal counseling and advisory services.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         The Company's Bylaws and the Delaware General Corporation Law provide
for indemnification of directors and officers against certain liabilities.
Officers and directors of the Company are indemnified generally against expenses
actually and reasonably incurred in connection with proceedings, whether civil
or criminal, provided that it is determined that they acted in good faith, were
not found guilty, and, in any criminal matter, had reasonable cause to believe
that their conduct was not unlawful.

         The Company's Certificate of Incorporation further provides that a
director of the Company shall not be personally liable for monetary damages to
the Company or its shareholders for breach of any fiduciary duty as a director,
except for liability (i) for any breach of the director's duty of loyalty to the
Company or its stockholders; (ii) for acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law; (iii) for
the unlawful payments of dividends or stock redemption by the company or (iv)
for any transaction from which the director derives an improper personal
benefit.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

         Not applicable.

ITEM 8.  EXHIBITS.
         The exhibits required by Item 601 of Regulation S-K are listed in the
Exhibit Index hereto.

                                       2
ITEM 9.  UNDERTAKINGS.

(a)  The undersigned Company hereby undertakes:

     1)   To file, during any period in which offers or sales are being made, a
          post-effective amendment to this registration statement:

          (i)  To include any prospectus required by Section 10(a)(3) of the
               Securities Act of 1933 (the "Securities Act");

          (ii) To reflect in the prospectus any facts or events arising after
               the effective date of this registration statement (or the most
               recent post-effective amendment thereof) which, individually or
               in the aggregate, represent a fundamental change in the
               information set forth in this registration statement.
               Notwithstanding the foregoing, any increase or decrease in the
               volume of securities offered (if the total dollar value of
               securities offered would not exceed that which was registered)
               and any deviation from the low or high end of the estimated
               maximum offering range may be reflected in the form of prospectus
               filed with the Commission pursuant to Rule 424(b) if, in the
               aggregate, the changes in volume and price represent no more than
               20 percent change in the maximum aggregate offering price set
               forth in the "Calculation of Registration Fee" table in the
               effective registration statement; and

         (iii) To include any material information with respect to the plan of
               distribution not previously disclosed in this registration
               statement or any material change to such information in this
               registration statement; provided, however, that paragraphs
               (a)(1)(i) and (a)(l)(ii) do not apply if the information required
               to be included in a post-effective amendment by those paragraphs
               is contained in periodic reports filed by the Company pursuant to
               Section 13 or Section 15(d) of the Exchange Act that are
               incorporated by reference in this registration statement.

     2)   That, for the purpose of determining any liability under the
          Securities Act, each such post-effective amendment shall be deemed to
          be a new registration statement relating to the securities offered
          therein, and the offering of such securities at that time shall be
          deemed to be the initial bona fide offering thereof.

     3)   To remove from registration by means of a post-effective amendment any
          of the securities being registered which remain unsold at the
          termination of the offering.

(b) The undersigned Company hereby undertakes that, for purposes of determining
any liability under the Securities Act, each filing of the Company's annual
report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and,
where applicable, each filing of an employee benefit plan's annual report
pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference
in this registration statement shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering
thereof.

(c) Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the Company
pursuant to the foregoing provisions, or otherwise, the Company has been advised
that in the opinion of the Commission such indemnification is against public
policy as expressed in the Securities Act and is, therefore, unenforceable. In
the event that a claim for indemnification against such liabilities (other than
the payment by the Company of expenses incurred or paid by a director, officer
or controlling person of the Company in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling person
in connection with the securities being registered, the Company will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.

                                       3
SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the Company
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized in the City of Clearwater, State of Florida on June 13, 2000.

                                       CRYO-CELL INTERNATIONAL, INC.

                                       By: /s/ Daniel D. Richard
                                           ---------------------------
                                       Daniel D. Richard
                                       Chief Executive Officer

                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below hereby constitutes and appoints Daniel D. Richard and each of
them, his true and lawful attorney-in-fact and agent, each with full power of
substitution and revocation, for him and in his name, place and stead, in any
and all capacities, to sign any and all amendments (including post-effective
amendments) to this registration statement, and to file the same with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto each such attorney-in-fact and
agent, full power and authority to do and perform each and every act and thing
requisite and necessary to be done, as fully to all intents and purposes as such
person might or could do in person, hereby ratifying and confirming all that
said attorney-in-fact and agent or his substitute or substitutes, may lawfully
do or cause to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
registration statement and the foregoing power of attorney have been signed by
the following persons in the capacities and on the dates indicated:
NAME                                    TITLE                                            DATE
----                                    -----                                            ----
/s/ Daniel D.Richard                    Chief Executive Officer and                     June 13, 2000
--------------------                    Chairman of the Board
Daniel D. Richard                       (Principal Executive Officer)

/s/ Wanda D. Dearth                     President and Chief Operating Officer           June 13, 2000
-------------------
Wanda D. Dearth

/s/ Gerald F. Maass                     Vice President and General                      June 13, 2000
-------------------                     Manager, Director
Gerald F. Maass

/s/ Jill M. Taymans                     Chief Financial Officer                         June 13, 2000
-------------------
Jill M. Taymans

/s/ Edward Modzelewski                  Director                                        June 13, 2000
----------------------
Edward Modzelewski

/s/ Frederick C.S. Wilhelm              Director                                        June 13, 2000
--------------------------
Frederick CS Wilhelm
4
EXHIBIT INDEX
EXHIBIT                                    DESCRIPTION OF EXHIBIT
NUMBER                                     ----------------------
-------
4.1              Retainer Agreement with Coleman Sudol

5.1              Opinion of Thaddeus Freeman as to the legality of the securities being registered.

23.1             Consent of Thaddeus Freeman (included in its opinion filed as Exhibit 5.1).

23.2             Consent of Weinick Sanders Leventhal & Co.

24               Power of Attorney (included with the signature page to this registration statement).
5