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    <td style="vertical-align: top; border-bottom: black 3pt double; padding: 0.25pt 0.05in 1pt 0.25pt; text-align: right; text-indent: 0.5in"><font style="font-size: 11pt">&nbsp;Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></td>
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    <p style="font: 17pt Times New Roman, Times, Serif; margin: 0; text-align: center"><b>UNITED STATES</b></p>
    <p style="font: 17pt Times New Roman, Times, Serif; margin: 0; text-align: center"><b>SECURITIES AND EXCHANGE COMMISSION</b></p></td>
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    <td style="vertical-align: top; padding: 0.25pt; text-align: center"><font style="font-size: 11pt"><b>Washington, D.C. 20549</b></font></td>
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    <td style="vertical-align: top; padding: 0.25pt; text-align: center"><font style="font-size: 17pt"><b>FORM S&#45;8</b></font></td>
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    <td style="vertical-align: top; padding: 0.25pt; text-align: center"><font style="font-size: 17pt"><b>REGISTRATION STATEMENT</b></font></td>
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    <p style="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 0.25pt; text-align: center"><b><i>Under</i></b></p>
    <p style="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 0.25pt; text-align: center"><b><i>The Securities Act of 1933</i></b></p></td>
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<p style="margin: 0">&nbsp;</p>
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  <td style="font-size: 1pt; width: 40%"><font style="font-size: 1pt">&nbsp;</font></td>
  <td style="font-size: 1pt; border-top: Black 1pt solid; width: 20%"><font style="font-size: 1pt">&nbsp;</font></td>
  <td style="font-size: 1pt; width: 40%"><font style="font-size: 1pt">&nbsp;</font></td></tr>
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    <td style="vertical-align: top; padding: 0.25pt; text-align: center"><a name="a_Hlk100655505"></a><font style="font-size: 17pt"><b>Pulse Biosciences, Inc.</b></font></td>
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    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; vertical-align: top; text-align: center; text-indent: 0.25pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>(Exact
    name of Registrant as specified in its charter)</b></font></td>
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  <td style="font: 1pt Times New Roman, Times, Serif; width: 40%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td>
  <td style="border-top: Black 1pt solid; font: 1pt Times New Roman, Times, Serif; width: 20%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td>
  <td style="font: 1pt Times New Roman, Times, Serif; width: 40%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td></tr>
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

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    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; width: 30%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Delaware</b></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; width: 40%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; width: 30%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>46-5696597</b></font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; text-indent: 0.25pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>(State
    or other jurisdiction of<br>incorporation or organization)</b></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; text-indent: 0.25pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; text-indent: 0.25pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>(I.R.S.
    Employer<br>
    Identification Number)</b></font></td></tr>
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    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; text-indent: 0.25pt; width: 30%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&#65279;</b></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; white-space: nowrap; width: 40%"><p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>3957
                                            Point Eden Way</b></font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; text-indent: 0.25pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Hayward,
    California 94545</b></font></p></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; text-indent: 0.25pt; width: 30%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
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    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; text-indent: 0.25pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; white-space: nowrap; text-align: center; text-indent: 0.25pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>(Address
    of Principal Executive Offices) (Zip Code)</b></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; text-indent: 0.25pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
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    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; vertical-align: top; width: 28%"><p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2017
    Equity Incentive Plan</b></font></p></td>
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  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; vertical-align: top; text-align: center; text-indent: 0.25pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>(Full
    title of the plan)</b></font></td>
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  <td style="font: 1pt Times New Roman, Times, Serif; width: 40%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td>
  <td style="border-top: Black 1pt solid; font: 1pt Times New Roman, Times, Serif; width: 20%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td>
  <td style="font: 1pt Times New Roman, Times, Serif; width: 40%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td></tr>
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

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    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; width: 30%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; width: 40%"><p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Kevin
    P. Danahy</b></font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Chief
    Executive Officer</b></font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Pulse
    Biosciences, Inc.</b></font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>3957
    Point Eden Way</b></font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Hayward,
    California 94545</b></font></p></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; width: 30%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>(Name
    and address of agent for service)</b></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>

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<tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: left">
  <td style="font: 10pt Times New Roman, Times, Serif; width: 40%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td>
  <td style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 20%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td>
  <td style="font: 10pt Times New Roman, Times, Serif; width: 40%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td></tr>
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

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    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; width: 30%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; width: 40%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>(510)
    906-4600</b></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; width: 30%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center"><p style="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>(Telephone
                                            number, including area code, of agent for service)</b></font></p></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>
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<tr style="font: 1pt Times New Roman, Times, Serif; vertical-align: top; text-align: left">
  <td style="font: 1pt Times New Roman, Times, Serif; width: 40%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td>
  <td style="border-top: Black 1pt solid; font: 1pt Times New Roman, Times, Serif; width: 20%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td>
  <td style="font: 1pt Times New Roman, Times, Serif; width: 40%"><font style="font-family: Times New Roman, Times, Serif; font-size: 1pt">&nbsp;</font></td></tr>
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

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    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; width: 30%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; width: 40%"><p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Copies
    to:</i></font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Adam
    W. Finerman</b></font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Baker
    &amp; Hostetler LLP</b></font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>45
    Rockefeller Center</b></font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>New
    York, NY 10111</b></font></p>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>(212)
    589-4233</b></font></p></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; text-align: center; width: 30%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

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    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt; vertical-align: bottom"><p style="font: 10pt Times New Roman, Times, Serif; margin: 0"></p>
    <p style="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company or an emerging growth company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;smaller reporting company&rdquo;
and &ldquo;emerging growth company&rdquo; in Rule 12b-2 of the Exchange Act.</font></p></td>
    </tr>
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 4in; text-align: right"></p>




<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></p>

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<tr style="vertical-align: top; text-align: left">
  <td style="width: 50%">Large accelerated filer &#9744;</td>
  <td style="width: 50%">Accelerated filer &#9744;</td></tr>
<tr style="vertical-align: top; text-align: left">
  <td>Non-accelerated
    filer &#9746;&#9;</td>
  <td>Smaller reporting company &#9746;</td></tr>
<tr style="vertical-align: top; text-align: left">
  <td>&nbsp;</td>
  <td>Emerging
    growth company &#9744;</td></tr>
</table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>EXPLANATORY
NOTE</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&nbsp;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Pursuant
to General Instruction E of Form S-8, the Registrant is filing this Registration Statement on Form S-8 with the U.S. Securities and Exchange
Commission (the &ldquo;Commission&rdquo;) to register 1,200,000 additional shares of the Registrant&rsquo;s common stock, par value $0.001
per share (the &ldquo;Common Stock&rdquo;) under the Company&rsquo;s 2017 Equity Incentive Plan (the &ldquo;Incentive Plan&rdquo;) pursuant
to the provisions of the Incentive Plan providing for an automatic annual increase in the number of shares reserved for issuance under
the Incentive Plan. This Registration Statement hereby incorporates by reference the contents of the Registrant&rsquo;s registration
statement on Form S-8 filed with the Commission on January 17, 2018 (Registration No. 333-222582).</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>PART
I</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&nbsp;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>INFORMATION
REQUIRED IN THE PROSPECTUS</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
information specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this Registration Statement on Form S-8 (the &ldquo;Registration
Statement&rdquo;) in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;),
and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I of Form S-8 will be delivered
to the participants of the Incentive Plan covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities
Act.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>PART
II</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&nbsp;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>INFORMATION
REQUIRED IN REGISTRATION STATEMENT</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Item
3. Incorporation of Documents by Reference</b>.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Pulse
Biosciences, Inc. (the &ldquo;Registrant&rdquo;) hereby incorporates by reference into this Registration Statement the following documents
previously filed with the Commission, in each case excluding any information &ldquo;furnished&rdquo; but not &ldquo;filed,&rdquo; unless
the Company specifically provides that such &ldquo;furnished&rdquo; information is to be incorporated by reference:</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 12pt"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
                                            Registrant&rsquo;s Annual Report on Form 10-K for its fiscal year ended December 31, 2022,
                                            filed with the Commission on March 31, 2023&nbsp;pursuant to Section 13(a) of the Securities
                                            Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;);</font></td></tr></table>

<p style="margin-top: 0; margin-bottom: 0"></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in"></p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin: 0; width: 100%"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</font></td><td style="text-align: justify; font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
                                            Registrant&rsquo;s Current Reports on Form 8-K filed with the Commission pursuant to the
                                            Exchange Act on each of March 21, 2023, March 30, 2023, May 1, 2023, May 5, 2023, and May
                                            9, 2023, respectively;</font></td></tr></table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 12pt"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">All
                                            other reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act since
                                            the end of the fiscal year covered by the Registrant&rsquo;s Annual Report referred to in
                                            (a) above; and </font></td></tr></table>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 12pt"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(d)</font></td><td style="text-align: justify; font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
                                            description of the Registrant&rsquo;s Common Stock contained in the Registrant&rsquo;s Registration
                                            Statement on Form 8-A (File No. 001-37744) filed with the Commission on April 15, 2016, pursuant
                                            to Section 12(b) of the Exchange Act, including any amendment or report filed for the purpose
                                            of updating such description.</font></td></tr></table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">All
documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration
Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered
have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference in this Registration
Statement and to be part hereof from the date of filing of such documents.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Any
statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded
for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document
which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified
or <font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">superseded
shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</font></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify">
<font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>


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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&nbsp;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Item
4. Description of Securities.</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 67.5pt; text-indent: -67.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Not
applicable.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 67.5pt; text-indent: -67.5pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Item
5. Interests of Named Experts and Counsel.</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Not
applicable. &#65279;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: 0.4in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Item
6. Indemnification of Directors and Officers.</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&nbsp;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Under
Section 145 of the Delaware General Corporation Law, Registrant has broad powers to indemnify its directors and officers against liabilities
they may incur in such capacities, including liabilities under the Securities Act. Registrant&rsquo;s Bylaws (the &ldquo;Bylaws&rdquo;)
provide that Registrant shall indemnify its directors and officers if such officer or director acted (i) in good faith, (ii) in a manner
reasonably believed to be in or not opposed to the best interests of Registrant, and (iii) with respect to any criminal action or proceeding,
had no reasonable cause to believe such conduct was unlawful. Registrant believes that indemnification under its Bylaws covers at least
negligence and gross negligence, and requires Registrant to advance litigation expenses in the case of stockholder derivative actions
or other actions, against an undertaking by the directors and officers to repay such advances if it is ultimately determined that the
director is not entitled to indemnification. The Bylaws further provide that rights conferred under such Bylaws shall not be deemed to
be exclusive of any other right such persons may have or acquire under any agreement, vote of stockholders or disinterested directors,
or otherwise.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In
addition, Registrant&rsquo;s Certificate of Incorporation (the &ldquo;Certificate of Incorporation&rdquo;) provides that, pursuant to
Delaware law, none of its directors shall be liable for monetary damages for breach of his or her fiduciary duty of care to Registrant
and its stockholders to the fullest extent permitted by the Delaware General Corporation Law as it presently exists or may hereafter
be amended from time to time. This provision in the Certificate of Incorporation does not eliminate the duty of care, and in appropriate
circumstances equitable remedies such as injunctive or other forms of non-monetary relief will remain available under Delaware law. In
addition, each director will continue to be subject to liability for breach of the director&rsquo;s duty of loyalty to Registrant for
acts or omissions not in good faith or involving intentional misconduct, for knowing violations of law, for actions leading to improper
personal benefit to the director, and for payment of dividends or approval of stock repurchases or redemptions that are in willful or
negligent violation of applicable Delaware law. The provision also does not affect a director&rsquo;s responsibilities under any other
law, such as the federal securities laws or state or federal environmental laws. The Certificate of Incorporation further provides that
Registrant shall indemnify its directors and officers to the fullest extent permitted by law and requires Registrant to advance litigation
expenses in the case of stockholder derivative actions or other actions, against an undertaking by the director to repay such advances
if it is ultimately determined that the director is not entitled to indemnification. The Certificate of Incorporation also provides that
rights conferred under such Certificate of Incorporation shall not be deemed to be exclusive of any other right such persons may have
or acquire under any statute, the Certificate of Incorporation, the Bylaws, agreement, vote of stockholders or disinterested directors,
or otherwise.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Registrant
has obtained liability insurance policies for the officers and directors that, subject to certain limitations, terms and conditions,
will insure them against losses arising from wrongful acts (as defined by the policy) in their capacity as directors or officers.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">In
addition, Registrant has entered into agreements to indemnify its directors and certain of its officers in addition to the indemnification
provided for in the Certificate of Incorporation and Bylaws. These agreements, among other things, indemnify Registrant&rsquo;s directors
and certain of its officers for certain expenses (including attorney&rsquo;s fees), judgments, fines and settlement amounts incurred
by such person in any action or proceeding, including any action by or in the right of Registrant, on account of services as a director
or officer of Registrant or as a director or officer of any subsidiary of Registrant, or as a director or officer of any other company
or enterprise that the person provides services to at the request of Registrant.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">See
also the undertakings set out in response to Item 9 herein.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1.4in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Item
7. Exemption from Registration Claimed.</b></font></p>




<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&#65279;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1.4in; text-indent: -1.4in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Not
applicable.<b>&nbsp;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&nbsp;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Item
8. Exhibits.</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&#65279;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1.4in; text-indent: -1.4in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
following exhibits are filed as part of this Registration Statement.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1.4in; text-indent: -1.4in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">
    <td colspan="2" style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt"><p style="border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&#65279;</b></font></p></td>
    <td colspan="4" style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt"><p style="border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Incorporated
    by Reference</b></font></p></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; width: 13%"><p style="border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Exhibit
    N</b>&nbsp;<b>umber</b></font></p></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; width: 42%"><p style="border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Description</b></font></p></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; width: 10%"><p style="border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Form</b></font></p></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; width: 13%"><p style="border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>File
    No.</b></font></p></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; width: 7%"><p style="border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Exhibit</b></font></p></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; width: 15%"><p style="border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Filing
    Date</b></font></p></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;<a href="https://www.sec.gov/Archives/edgar/data/1625101/000162510118000036/plse-20180618xex4_1.htm">4.1</a></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
    of Common Stock certificate of the Registrant</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">8-K12B</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">001-37744</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.1</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">June
    18, 2018</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;<a href="https://www.sec.gov/Archives/edgar/data/1625101/000156276217000071/plse-20170519xex10_1.htm">4.2</a></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Pulse
    Biosciences, Inc. 2017 Equity Incentive Plan, as amended, and forms of agreement thereunder.</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">8-K</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">001-37744</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">10.1</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">May
    19, 2017</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;<a href="ex5-1.htm">5.1*</a></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Opinion
    of Baker &amp; Hostetler LLP, counsel to the Registrant</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;<a href="ex23-1.htm">23.1*</a></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Consent
    of Independent Registered Public Accounting Firm</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;<a href="ex5-1.htm">23.2*</a></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Consent
    of BakerHostetler LLP (included in Exhibit 5.1)</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;<a href="#POA">24.1*</a></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Power
    of Attorney (contained on signature pages hereto)</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="font: 10pt Times New Roman, Times, Serif; vertical-align: top; padding-right: 8.65pt; padding-left: 8.65pt; text-align: center; text-indent: -8.65pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><a href="ex-107.htm">107*</a></font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Filing
    Fee Table</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">*
Filed herewith.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Item
9. Undertakings.</b></font></p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 9.3pt; margin-bottom: 0"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">A.</font></td><td style="font: 10pt Times New Roman, Times, Serif; padding-right: 0.75in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
                                            undersigned Registrant hereby undertakes:</font></td></tr></table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in"></p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 9.3pt; margin-bottom: 0"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.5in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(1)</font></td><td style="font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">To
                                            file, during any period in which offers or sales are being made, a post-effective amendment
                                            to this Registration Statement:</font></td></tr></table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.75in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 12pt"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.75in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(i)</font></td><td style="font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">To
                                            include any prospectus required by Section 10(a)(3) of the Securities Act;</font></td></tr></table>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 12pt"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.75in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(ii)</font></td><td style="text-align: justify; font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">To
                                            reflect in the prospectus any facts or events arising after the effective date of the Registration
                                            Statement (or the most recent post-effective amendment thereof) which, individually or in
                                            the aggregate, represent a fundamental change in the information set forth in the Registration
                                            Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities
                                            offered (if the total dollar value of securities offered would not exceed that which was
                                            registered) and any deviation from the low or high end of the estimated maximum offering
                                            range may be reflected in the form of prospectus filed with the Commission pursuant to Rule
                                            424(b) if, in the aggregate, the changes in volume and price represent no more than a 20
                                            percent change in the maximum aggregate offering price set forth in the &ldquo;Calculation
                                            of Registration Fee&rdquo; table in the effective registration statement; and </font></td></tr></table>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 12pt"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.75in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(iii)</font></td><td style="text-align: justify; font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">To
                                            include any material information with respect to the plan of distribution not previously
                                            disclosed in the registration statement or any material change to such information in the
                                            registration statement.&#65279;</font></td></tr></table>


<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-align: justify; text-indent: 0.4in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i></i></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-align: justify; text-indent: 0.4in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>Provided,
however,</i> that paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section
15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.</font></p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 10.25pt; margin-bottom: 0"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.5in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(2)</font></td><td style="text-align: justify; font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">That,
                                            for the purpose of determining any liability under the Securities Act, each such post-effective
                                            amendment shall be deemed to be a new registration statement relating to the securities offered
                                            therein, and the offering of such securities at that time shall be deemed to be the initial
                                            <i>bona fide</i> offering thereof.</font></td></tr></table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.75in"></p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 10.25pt; margin-bottom: 0"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.5in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(3)</font></td><td style="text-align: justify; font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">To
                                            remove from registration by means of a post-effective amendment any of the securities being
                                            registered which remain unsold at the termination of the offering.</font></td></tr></table>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 0"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 1.4in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td><td style="font: 10pt Times New Roman, Times, Serif; padding-right: 0.9in"></td></tr></table>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 0"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">B.</font></td><td style="text-align: justify; font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">The
                                            undersigned Registrant hereby undertakes that, for purposes of determining any liability
                                            under the Securities Act, each filing of the Registrant&rsquo;s annual report pursuant to
                                            Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of
                                            an employee benefit plan&rsquo;s annual report pursuant to Section 15(d) of the Exchange
                                            Act) that is incorporated by reference in the registration statement shall be deemed to be
                                            a new registration statement relating to the securities offered therein, and the offering
                                            of such securities at that time shall be deemed to be the initial <i>bona fide</i> offering
                                            thereof.</font></td></tr></table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 0"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
<td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">C.</font></td><td style="text-align: justify; font: 10pt Times New Roman, Times, Serif"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Insofar
                                            as indemnification for liabilities arising under the Securities Act may be permitted to directors,
                                            officers and controlling persons of the Registrant pursuant to the foregoing provisions,
                                            or otherwise, the Registrant has been advised that in the opinion of the Commission such
                                            indemnification is against public policy as expressed in the Securities Act and is, therefore,
                                            unenforceable. In the event that a claim for indemnification against such liabilities (other
                                            than the payment by the Registrant of expenses incurred or paid by a director, officer or
                                            controlling person of the Registrant in the successful defense of any action, suit or proceeding)
                                            is asserted by such director, officer or controlling person in connection with the securities
                                            being registered, the Registrant will, unless in the opinion of its counsel the matter has
                                            been settled by controlling precedent, submit to a court of appropriate jurisdiction the
                                            question whether such indemnification by it is against public policy as expressed in the
                                            Securities Act and will be governed by the final adjudication of such issue.</font></td></tr></table>

<p style="margin-right: 0; font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>


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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&nbsp;</b></font></p>

<p style="font: 10pt/10.9pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>SIGNATURES</b></font></p>

<p style="font: 10pt/10.9pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&nbsp;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Pursuant
to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Hayward, California, on May 10, 2023.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt; background-color: yellow">&#65279;</font></p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td colspan="2" style="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>PULSE
    BIOSCIENCES, INC.</b></font></td>
    <td>&nbsp;</td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; width: 60%; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; width: 3%; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; width: 20%; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="width: 17%">&nbsp;</td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</font></td>
    <td style="white-space: nowrap; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
    Kevin P. Danahy</font></td>
    <td>&nbsp;</td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Kevin
    P. Danahy</font></td>
    <td>&nbsp;</td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 0.1in 0.25pt 6.75pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="white-space: nowrap; font: 10pt Times New Roman, Times, Serif; padding: 0.25pt 6.75pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief
    Executive Officer</font></td>
    <td>&nbsp;</td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt; background-color: yellow">&#65279;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><a name="POA"></a><b>POWER OF ATTORNEY</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>&#65279;</b></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Each
person whose signature appears below hereby constitutes and appoints Kevin P. Danahy, as his true and lawful attorney-in-fact and agent
with full power of substitution, for him in any and all capacities, to sign any and all amendments to this Registration Statement on
Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto and other documents in connection therewith,
with the Securities and Exchange Commission, granting unto said attorney-in-fact, proxy and agent full power and authority to do and
perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes
as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact, proxy and agent, or his substitute,
may lawfully do or cause to be done by virtue hereof.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement
on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 1in; text-align: justify; text-indent: 0.4in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; width: 20%"><p style="text-indent: 0; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Signature</b></font></p></td>
    <td style="padding: 0; width: 10%; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; width: 40%"><p style="text-indent: 0; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Title</b></font></p></td>
    <td style="padding: 0; width: 10%; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; width: 20%"><p style="text-indent: 0; border-bottom: black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Date</b></font></p></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">
    <td style="text-indent: 0; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
    Kevin P. Danahy</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief
    Executive Officer</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">May
    10, 2023</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Kevin
    P. Danahy</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(Principal
    Executive and Principal Financial Officer)</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">
    <td style="text-indent: 0; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
    Robert W. Duggan</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Executive
    Chairman of the Board of Directors</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">May
    10, 2023</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Robert
    W. Duggan</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="text-indent: 0; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
    Darrin R. Uecker</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief
    Technology Officer and Director</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">May
    10, 2023</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Darrin
    R. Uecker</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="text-indent: 0; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
    Mitchell E. Levinson</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief
    Strategy Officer and Director</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">May
    10, 2023</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mitchell
    E. Levinson</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="text-indent: 0; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
    Shelley D. Spray</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">May
    10, 2023</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shelley
    D. Spray</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="text-indent: 0; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
    Manmeet S. Soni</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">May
    10, 2023</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Manmeet
    S. Soni</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#65279;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="text-indent: 0; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
    Mahkam Zanganeh</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">May
    10, 2023</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mahkam
    Zanganeh</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0">&nbsp;</td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center">&nbsp;</td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0">&nbsp;</td></tr>

<tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="text-indent: 0; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
    Richard A. van den Broek</font></td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></font></td>
    <td style="text-indent: 0; text-align: center; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: bottom"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;Director</font></td><td style="padding: 0; text-indent: 0">&nbsp;</td><td style="padding: 0; text-align: center; text-indent: 0">May
    10, 2023</td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Richard
    A. van den Broek</font></td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td><td style="padding: 0; text-indent: 0">&nbsp;</td><td style="padding: 0; text-indent: 0">&nbsp;</td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0">&nbsp;</td><td style="padding: 0; text-indent: 0">&nbsp;</td><td style="padding: 0; text-indent: 0">&nbsp;</td></tr>

<tr style="font: 10pt Times New Roman, Times, Serif">
    <td style="text-indent: 0; border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/
    Timothy H. Mitsuoka</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: top; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Corporate
    Controller</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; vertical-align: bottom; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">May&nbsp;&nbsp;10,
    2023</font></td></tr>
  <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top">
    <td style="text-indent: 0; border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Timothy
    H. Mitsuoka</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(Principal
    Accounting Officer)</font></td>
    <td style="padding: 0; text-indent: 0">&nbsp;</td>
    <td style="text-indent: 0; font: 10pt Times New Roman, Times, Serif; padding: 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</font></td></tr>
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[{"type": "S-8", "sequence": "1", "filename": "pulse-s8_051023.htm", "description": "INITIAL REGISTRATION STATEMENT", "secsgml_size_bytes": 105323}]
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Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
Pulse Biosciences, Inc.
(Exact
    name of Registrant as specified in its charter)
Delaware
46-5696597
(State
    or other jurisdiction of
incorporation or organization)
(I.R.S.
    Employer
Identification Number)
﻿
3957
                                            Point Eden Way
Hayward,
    California 94545
﻿
(Address
    of Principal Executive Offices) (Zip Code)
2017
    Equity Incentive Plan
(Full
    title of the plan)
﻿
Kevin
    P. Danahy
Chief
    Executive Officer
Pulse
    Biosciences, Inc.
3957
    Point Eden Way
Hayward,
    California 94545
(Name
    and address of agent for service)
﻿
(510)
    906-4600
(Telephone
                                            number, including area code, of agent for service)
﻿
Copies
    to:
Adam
    W. Finerman
Baker
    & Hostetler LLP
45
    Rockefeller Center
New
    York, NY 10111
(212)
    589-4233
Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company or an emerging growth company. See the definitions of "large accelerated filer," "smaller reporting company"
and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☐
Accelerated filer ☐
Non-accelerated
    filer ☒
Smaller reporting company ☒
Emerging
    growth company ☐
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY
NOTE
Pursuant
to General Instruction E of Form S-8, the Registrant is filing this Registration Statement on Form S-8 with the U.S. Securities and Exchange
Commission (the "Commission") to register 1,200,000 additional shares of the Registrant's common stock, par value $0.001
per share (the "Common Stock") under the Company's 2017 Equity Incentive Plan (the "Incentive Plan") pursuant
to the provisions of the Incentive Plan providing for an automatic annual increase in the number of shares reserved for issuance under
the Incentive Plan. This Registration Statement hereby incorporates by reference the contents of the Registrant's registration
statement on Form S-8 filed with the Commission on January 17, 2018 (Registration No. 333-222582).
PART
I
INFORMATION
REQUIRED IN THE PROSPECTUS
The
information specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this Registration Statement on Form S-8 (the "Registration
Statement") in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the "Securities Act"),
and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I of Form S-8 will be delivered
to the participants of the Incentive Plan covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities
Act.
PART
II
INFORMATION
REQUIRED IN REGISTRATION STATEMENT
Item
3. Incorporation of Documents by Reference
.
Pulse
Biosciences, Inc. (the "Registrant") hereby incorporates by reference into this Registration Statement the following documents
previously filed with the Commission, in each case excluding any information "furnished" but not "filed," unless
the Company specifically provides that such "furnished" information is to be incorporated by reference:
(a)
The
                                            Registrant's Annual Report on Form 10-K for its fiscal year ended December 31, 2022,
                                            filed with the Commission on March 31, 2023 pursuant to Section 13(a) of the Securities
                                            Exchange Act of 1934, as amended (the "Exchange Act");
(b)
The
                                            Registrant's Current Reports on Form 8-K filed with the Commission pursuant to the
                                            Exchange Act on each of March 21, 2023, March 30, 2023, May 1, 2023, May 5, 2023, and May
                                            9, 2023, respectively;
(c)
All
                                            other reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act since
                                            the end of the fiscal year covered by the Registrant's Annual Report referred to in
                                            (a) above; and
(d)
The
                                            description of the Registrant's Common Stock contained in the Registrant's Registration
                                            Statement on Form 8-A (File No. 001-37744) filed with the Commission on April 15, 2016, pursuant
                                            to Section 12(b) of the Exchange Act, including any amendment or report filed for the purpose
                                            of updating such description.
All
documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration
Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered
have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference in this Registration
Statement and to be part hereof from the date of filing of such documents.
Any
statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded
for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document
which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified
or
superseded
shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item
4. Description of Securities.
Not
applicable.
Item
5. Interests of Named Experts and Counsel.
Not
applicable. ﻿
Item
6. Indemnification of Directors and Officers.
Under
Section 145 of the Delaware General Corporation Law, Registrant has broad powers to indemnify its directors and officers against liabilities
they may incur in such capacities, including liabilities under the Securities Act. Registrant's Bylaws (the "Bylaws")
provide that Registrant shall indemnify its directors and officers if such officer or director acted (i) in good faith, (ii) in a manner
reasonably believed to be in or not opposed to the best interests of Registrant, and (iii) with respect to any criminal action or proceeding,
had no reasonable cause to believe such conduct was unlawful. Registrant believes that indemnification under its Bylaws covers at least
negligence and gross negligence, and requires Registrant to advance litigation expenses in the case of stockholder derivative actions
or other actions, against an undertaking by the directors and officers to repay such advances if it is ultimately determined that the
director is not entitled to indemnification. The Bylaws further provide that rights conferred under such Bylaws shall not be deemed to
be exclusive of any other right such persons may have or acquire under any agreement, vote of stockholders or disinterested directors,
or otherwise.
In
addition, Registrant's Certificate of Incorporation (the "Certificate of Incorporation") provides that, pursuant to
Delaware law, none of its directors shall be liable for monetary damages for breach of his or her fiduciary duty of care to Registrant
and its stockholders to the fullest extent permitted by the Delaware General Corporation Law as it presently exists or may hereafter
be amended from time to time. This provision in the Certificate of Incorporation does not eliminate the duty of care, and in appropriate
circumstances equitable remedies such as injunctive or other forms of non-monetary relief will remain available under Delaware law. In
addition, each director will continue to be subject to liability for breach of the director's duty of loyalty to Registrant for
acts or omissions not in good faith or involving intentional misconduct, for knowing violations of law, for actions leading to improper
personal benefit to the director, and for payment of dividends or approval of stock repurchases or redemptions that are in willful or
negligent violation of applicable Delaware law. The provision also does not affect a director's responsibilities under any other
law, such as the federal securities laws or state or federal environmental laws. The Certificate of Incorporation further provides that
Registrant shall indemnify its directors and officers to the fullest extent permitted by law and requires Registrant to advance litigation
expenses in the case of stockholder derivative actions or other actions, against an undertaking by the director to repay such advances
if it is ultimately determined that the director is not entitled to indemnification. The Certificate of Incorporation also provides that
rights conferred under such Certificate of Incorporation shall not be deemed to be exclusive of any other right such persons may have
or acquire under any statute, the Certificate of Incorporation, the Bylaws, agreement, vote of stockholders or disinterested directors,
or otherwise.
Registrant
has obtained liability insurance policies for the officers and directors that, subject to certain limitations, terms and conditions,
will insure them against losses arising from wrongful acts (as defined by the policy) in their capacity as directors or officers.
In
addition, Registrant has entered into agreements to indemnify its directors and certain of its officers in addition to the indemnification
provided for in the Certificate of Incorporation and Bylaws. These agreements, among other things, indemnify Registrant's directors
and certain of its officers for certain expenses (including attorney's fees), judgments, fines and settlement amounts incurred
by such person in any action or proceeding, including any action by or in the right of Registrant, on account of services as a director
or officer of Registrant or as a director or officer of any subsidiary of Registrant, or as a director or officer of any other company
or enterprise that the person provides services to at the request of Registrant.
See
also the undertakings set out in response to Item 9 herein.
Item
7. Exemption from Registration Claimed.
﻿
Not
applicable.
Item
8. Exhibits.
﻿
The
following exhibits are filed as part of this Registration Statement.
﻿
﻿
Incorporated
    by Reference
Exhibit
    N
umber
Description
Form
File
    No.
Exhibit
Filing
    Date
﻿
4.1
Form
    of Common Stock certificate of the Registrant
8-K12B
001-37744
4.1
June
    18, 2018
﻿
4.2
Pulse
    Biosciences, Inc. 2017 Equity Incentive Plan, as amended, and forms of agreement thereunder.
8-K
001-37744
10.1
May
    19, 2017
﻿
5.1*
Opinion
    of Baker & Hostetler LLP, counsel to the Registrant
﻿
23.1*
Consent
    of Independent Registered Public Accounting Firm
﻿
23.2*
Consent
    of BakerHostetler LLP (included in Exhibit 5.1)
﻿
24.1*
Power
    of Attorney (contained on signature pages hereto)
107*
Filing
    Fee Table
*
Filed herewith.
Item
9. Undertakings.
A.
The
                                            undersigned Registrant hereby undertakes:
(1)
To
                                            file, during any period in which offers or sales are being made, a post-effective amendment
                                            to this Registration Statement:
(i)
To
                                            include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
To
                                            reflect in the prospectus any facts or events arising after the effective date of the Registration
                                            Statement (or the most recent post-effective amendment thereof) which, individually or in
                                            the aggregate, represent a fundamental change in the information set forth in the Registration
                                            Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities
                                            offered (if the total dollar value of securities offered would not exceed that which was
                                            registered) and any deviation from the low or high end of the estimated maximum offering
                                            range may be reflected in the form of prospectus filed with the Commission pursuant to Rule
                                            424(b) if, in the aggregate, the changes in volume and price represent no more than a 20
                                            percent change in the maximum aggregate offering price set forth in the "Calculation
                                            of Registration Fee" table in the effective registration statement; and
(iii)
To
                                            include any material information with respect to the plan of distribution not previously
                                            disclosed in the registration statement or any material change to such information in the
                                            registration statement.﻿
Provided,
however,
that paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section
15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
(2)
That,
                                            for the purpose of determining any liability under the Securities Act, each such post-effective
                                            amendment shall be deemed to be a new registration statement relating to the securities offered
                                            therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(3)
To
                                            remove from registration by means of a post-effective amendment any of the securities being
                                            registered which remain unsold at the termination of the offering.
﻿
B.
The
                                            undersigned Registrant hereby undertakes that, for purposes of determining any liability
                                            under the Securities Act, each filing of the Registrant's annual report pursuant to
                                            Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of
                                            an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange
                                            Act) that is incorporated by reference in the registration statement shall be deemed to be
                                            a new registration statement relating to the securities offered therein, and the offering
                                            of such securities at that time shall be deemed to be the initial
bona fide
offering
                                            thereof.
C.
Insofar
                                            as indemnification for liabilities arising under the Securities Act may be permitted to directors,
                                            officers and controlling persons of the Registrant pursuant to the foregoing provisions,
                                            or otherwise, the Registrant has been advised that in the opinion of the Commission such
                                            indemnification is against public policy as expressed in the Securities Act and is, therefore,
                                            unenforceable. In the event that a claim for indemnification against such liabilities (other
                                            than the payment by the Registrant of expenses incurred or paid by a director, officer or
                                            controlling person of the Registrant in the successful defense of any action, suit or proceeding)
                                            is asserted by such director, officer or controlling person in connection with the securities
                                            being registered, the Registrant will, unless in the opinion of its counsel the matter has
                                            been settled by controlling precedent, submit to a court of appropriate jurisdiction the
                                            question whether such indemnification by it is against public policy as expressed in the
                                            Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant
to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Hayward, California, on May 10, 2023.
﻿
﻿
PULSE
    BIOSCIENCES, INC.
﻿
﻿
By:
/s/
    Kevin P. Danahy
﻿
Kevin
    P. Danahy
﻿
Chief
    Executive Officer
﻿
POWER OF ATTORNEY
﻿
Each
person whose signature appears below hereby constitutes and appoints Kevin P. Danahy, as his true and lawful attorney-in-fact and agent
with full power of substitution, for him in any and all capacities, to sign any and all amendments to this Registration Statement on
Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto and other documents in connection therewith,
with the Securities and Exchange Commission, granting unto said attorney-in-fact, proxy and agent full power and authority to do and
perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes
as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact, proxy and agent, or his substitute,
may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement
on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.
﻿
Signature
Title
Date
/s/
    Kevin P. Danahy
Chief
    Executive Officer
May
    10, 2023
Kevin
    P. Danahy
(Principal
    Executive and Principal Financial Officer)
﻿
/s/
    Robert W. Duggan
Executive
    Chairman of the Board of Directors
May
    10, 2023
Robert
    W. Duggan
﻿
/s/
    Darrin R. Uecker
Chief
    Technology Officer and Director
May
    10, 2023
Darrin
    R. Uecker
﻿
/s/
    Mitchell E. Levinson
Chief
    Strategy Officer and Director
May
    10, 2023
Mitchell
    E. Levinson
/s/
    Shelley D. Spray
Director
May
    10, 2023
Shelley
    D. Spray
/s/
    Manmeet S. Soni
Director
May
    10, 2023
Manmeet
    S. Soni
﻿
/s/
    Mahkam Zanganeh
Director
May
    10, 2023
Mahkam
    Zanganeh
/s/
    Richard A. van den Broek
Director
May
    10, 2023
Richard
    A. van den Broek
/s/
    Timothy H. Mitsuoka
Corporate
    Controller
May  10,
    2023
Timothy
    H. Mitsuoka
(Principal
    Accounting Officer)