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    <TD STYLE="width: 75%; font-size: 10pt"><B>As filed with the Securities and Exchange Commission o<FONT STYLE="font-family: Times New Roman, Times, Serif">n
</FONT>July 29, 2015 </B></TD>
    <TD STYLE="width: 25%; font-size: 10pt"><B>Registration No. 333-</B></TD></TR>
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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNITED STATES </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-size: 18pt"><B>SECURITIES
AND EXCHANGE COMMISSION</B></FONT><BR>
<B>WASHINGTON, D.C. 20549</B><BR>
<BR>
<FONT STYLE="font-size: 18pt"><B>FORM S-8</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</B></FONT><BR>
<BR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><BR>
<FONT STYLE="font-size: 18pt"><B>CYNAPSUS THERAPEUTICS INC.</B></FONT><BR>
(Exact name of registrant as specified in its charter)</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

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    <TD STYLE="width: 45%; padding-top: 3pt; padding-right: 1.45pt; padding-left: 1.45pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B><U>Canada</U></B></FONT><BR>
    (State or other jurisdiction of incorporation or organization)</TD>
    <TD STYLE="width: 10%; padding-top: 3pt; padding-bottom: 3pt; font-size: 10pt; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 45%; padding-top: 3pt; padding-bottom: 3pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B><U>Not
    Applicable</U></B></FONT><B> </B><BR>
    (I.R.S. Employer Identification No.)</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>828 Richmond
        Street West,</B><BR>
        <B><U>Toronto, Ontario, M6J 1C9, Canada</U></B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of Principal Executive Offices)
        (Zip Code)</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

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        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"><u>2014 AMENDED AND
        RESTATED STOCK OPTION PLAN</u></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"><FONT STYLE="font-weight: normal">(Full
title of the plan)</FONT>&nbsp;</P></td></tr>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>C T Corporation System</B><BR>
<B>111 Eighth Avenue</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><U>New York, NY 10011</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Name and address of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><U>(212) 590-9070</U></B><BR>
(Telephone number, including area code, of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">The Commission is requested to mail signed
copies of all orders, notices and communications to:</P>



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    <TD STYLE="width: 50%; font-size: 10pt; text-align: center"><b>Anthony Giovinazzo</b><br>
<b>Cynapsus&nbsp;Therapeutics&nbsp;Inc.</b><br>
<b>828 Richmond Street West</b><br>
<b>Toronto, Ontario</b><br>
<b>M6J 1C9 Canada</b><br>
<b>Telephone: (416) 703-2449</b></td>
    <TD STYLE="width: 50%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Thomas M. Rose, Esq. </b></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Troutman Sanders LLP </b></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>401 9th&nbsp;Street, N.W., Suite 1000</b><br>
        <b>Washington, D.C. 20004-2134</b></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Telephone: (757)&nbsp;687-7715</b></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Facsimile: (757)&nbsp;687-1529</b></P></td></tr>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2
of the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;&#9;</P>

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    <TD STYLE="width: 50%; font-size: 10pt">Large accelerated filer <FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="width: 30%; font-size: 10pt">Accelerated filer <FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">Non-accelerated filer <FONT STYLE="font-family: Wingdings">x</FONT> (Do not check if a smaller reporting company)</TD>
    <TD STYLE="font-size: 10pt">Smaller reporting company<FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: bottom">
    <TD STYLE="width: 29%; border-top: Black 2.25pt double; padding-right: 1.8pt; padding-left: 1.8pt; text-align: center; vertical-align: bottom">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Title of securities </b></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>to be registered (1)</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P></td>
    <TD STYLE="width: 16%; border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center; vertical-align: bottom"><b>Amount to be</b><br>
<b>registered (2)</b></td>
    <TD STYLE="width: 18%; border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center; vertical-align: bottom"><b>Proposed </b><br>
<b>maximum offering price per share</b></td>
    <TD STYLE="width: 22%; border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center; vertical-align: bottom"><b>Proposed </b><br>
<b>maximum </b><br>
<b>aggregate offering </b><br>
<b>price</b></td>
    <TD STYLE="width: 15%; border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center; vertical-align: bottom"><b>Amount of registration fee</b></td></tr>
<tr style="vertical-align: top">
    <td style="border-top: Black 1pt solid; border-bottom: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt">Common shares, no par value, subject to outstanding options</td>
    <td style="border-top: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center">581,501 shares</td>
    <td style="border-top: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center">$12.62 (3)(4)</td>
    <td style="border-top: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center">$7,338,542.62</td>
    <td style="border-top: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center">$852.74</td></tr>
<tr style="vertical-align: top">
    <td style="border-bottom: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt">Common shares, no par value, not subject to outstanding options</td>
    <td style="border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center">630,229<font style="font-family: Times New Roman, Times, Serif"> </font>shares</td>
    <td style="border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center">$16.51 (5)</td>
    <td style="border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center">$10,405,080.79</td>
    <td style="border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center">$1,209.07</td></tr>
<tr style="vertical-align: top">
    <td style="border-bottom: Black 2.25pt double; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt"><b>Total</b></td>
    <td style="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center">1,211,730 shares</td>
    <td style="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-top: 1pt; padding-bottom: 1pt; font-size: 10pt; text-align: center">&nbsp;</td>
    <td style="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-top: 1pt; padding-right: 1.8pt; padding-bottom: 1pt; font-weight: bold; text-align: center; text-indent: 0in; font-size: 10pt"><FONT STYLE="font-size: 10pt; font-weight: normal">$</FONT><FONT STYLE="font-weight: normal">17,743,623.41</FONT></td>
    <td style="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-top: 1pt; padding-right: 1.8pt; padding-bottom: 1pt; font-weight: bold; text-align: center; text-indent: 0in; font-size: 10pt"><FONT STYLE="font-size: 10pt; font-weight: normal">$</FONT><FONT STYLE="font-weight: normal">2,061.81</FONT></td></tr>
</table>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(1)</TD><TD STYLE="text-align: justify">Common shares, without par value, of Cynapsus Therapeutics Inc. (the &ldquo;<B>Registrant</B>&rdquo;)
pursuant to its 2014 Amended and Restated Stock Option Plan (the &ldquo;<B>Plan</B>&rdquo;).</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.3in; text-align: justify; text-indent: -0.3in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(2)</TD><TD STYLE="text-align: justify">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &ldquo;<B>Securities
Act</B>&rdquo;), this registration statement also covers an indeterminate number of additional shares that may be offered and issued
to prevent dilution resulting from stock splits, stock dividends or similar transactions as provided in the Plan.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.3in; text-align: justify; text-indent: -0.3in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.3in">(3)</TD><TD STYLE="text-align: justify">Based on the weighted average exercise price of Cdn$16.32 of options granted under the Plan outstanding
as of July 28, 2015.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.3in; text-align: justify; text-indent: -0.3in">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 22.5pt">(4)</TD><TD>U.S. dollar amounts are calculated based on the Bank of Canada noon rate of exchange reported on July 28, 2015, which was Cdn$1.00=US$0.7732.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-indent: -22.5pt">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 22.5pt">(5)</TD><TD>Calculated in accordance with Rule 457(c) and (h) based on the average of the high and low prices for the Registrant&rsquo;s
common shares reported on The NASDAQ Stock Market LLC on July 28, 2015, which was US$16.51 per share.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 22.5pt; text-indent: -22.5pt">&nbsp;</P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left">PART I.
&#9;INFORMATION REQUIRED IN THE SECTION 10(<FONT STYLE="text-transform: none">a) PROSPECTUS</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left"><FONT STYLE="text-transform: none">Item
1.&#9;Plan Information.*</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left"><FONT STYLE="text-transform: none">Item
2.&#9;Registrant Information and Employee Plan Annual Information.*</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left"><FONT STYLE="text-transform: none">*<FONT STYLE="font-weight: normal">The
information required by Part I to be contained in the Section 10(a) prospectus is omitted from this registration statement in accordance
with the Note to Part I of Form S-8 and Rule 428.</FONT></FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left"><FONT STYLE="text-transform: none">PAR</FONT>T
II.&#9;INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: left">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 3. Incorporation of Documents by Reference.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">The following documents,
which have been filed with the United States Securities and Exchange Commission (the &ldquo;<B>Commission</B>&rdquo;), are incorporated
herein by reference:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

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<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(a)</TD><TD STYLE="text-align: left">The Registrant&rsquo;s registration statement on Form F-10 (File No. 333-204226) (the &ldquo;<B>Registration
Statement on Form F-10</B>&rdquo;), initially filed with the Commission on May 15, 2015, as subsequently amended by any amendments
to such Registration Statement on Form F-10.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(b)</TD><TD STYLE="text-align: left">All other reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934,
as amended (the &ldquo;<B>Exchange Act</B>&rdquo;), since the end of the fiscal year covered by the Registration Statement on Form
F-10.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(c)</TD><TD STYLE="text-align: left">The description of the Registrant&rsquo;s securities contained in the registration statement on Form
8-A filed with the Commission on June 12, 2015 under Section 12(b) of the Exchange Act, including any amendment or report filed
for the purposes of updating such description.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">In
addition, unless otherwise stated herein, all documents subsequently filed with the Commission by the Registrant pursuant to Sections
13(a), 13(c), 14 or 15(d) of the Exchange Act prior to the filing of a post-effective amendment to this registration statement
which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall
be deemed to be incorporated by reference in this registration statement and to be a part hereof from the date of filing of such
documents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">Any
statement contained in a document incorporated or deemed to be incorporated by reference in this document will be deemed to be
modified or superseded for purposes of this registration statement to the extent that a statement contained in this document or
in any other subsequently filed document which also is or is deemed to be incorporated by reference in this document modifies
or supersedes such statement. Any such statement so modified or superseded will not be deemed, except as so modified or superseded,
to constitute a part of this registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 4. Description of Securities.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 5. Interests of Named Experts and Counsel.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">None.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 6. Indemnification of Directors and Officers.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">Under the&nbsp;<I>Canada
Business Corporations Act</I>, the Registrant may indemnify a director or officer of the Registrant, a former director or officer
of the Registrant or another individual who acts or acted at the Registrant&rsquo;s request as a director or officer, or an individual
acting in a similar capacity, of another entity, against all costs, charges and expenses, including an amount paid to settle an
action or satisfy a judgment, reasonably incurred by the individual in respect of any civil, criminal, administrative, investigative
or other proceeding in which the individual is involved because of that association with the Registrant or other entity and provided
that the director, officer or other individual acted honestly and in good faith with a view to the best interests of the Registrant,
or, as the case may be, to the best interests of the other entity for which the individual acted as a director or officer or in
a similar capacity at the Registrant&rsquo;s request and, in the case of a criminal or administrative action or proceeding that
is enforced by a monetary penalty, if the director, officer or other individual had reasonable grounds for believing that such
individual&rsquo;s conduct was lawful. Such indemnification may be made in connection with a derivative action only with court
approval. A director, officer or other individual referred to above is entitled to indemnification from the Registrant in respect
of all costs, charges and expenses reasonably incurred by the individual in connection with the defense of any civil, criminal,
administrative, investigative or other proceeding to which the individual is subject because of the individual&rsquo;s association
with the Registrant or other entity, as described above, if the individual was not judged by the court or other competent authority
to have committed any fault or omitted to do anything that the individual ought to have done and fulfilled the conditions set forth
above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 42.85pt; background-color: white"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 42.85pt; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 42.85pt; background-color: white"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">The Registrant
has entered into agreements with certain of its directors and executive officers providing for indemnification against certain
expenses as described above. A policy of directors&rsquo; and officers&rsquo; liability insurance is maintained by the Registrant
which insures directors and officers for losses as a result of claims against the directors and officers of the Registrant in their
capacity as directors and officers and also reimburses the Registrant for payments made pursuant to the indemnity provisions under
the Registrant&rsquo;s by-laws and the&nbsp;<I>Canada Business Corporations Act</I>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 42.85pt; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">Insofar as the
indemnification for liabilities arising under the Securities Act may be permitted to directors, officers or persons controlling
the Registrant pursuant to the foregoing provisions, the Registrant has been informed that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 7. Exemption from Registration Claimed.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">Not Applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 8. Exhibits.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD STYLE="width: 15%; padding-top: 3pt; padding-bottom: 3pt; text-align: center; text-decoration: underline"><b><u>Exhibit Number</u></b></td>
    <TD STYLE="width: 85%; padding-top: 3pt; padding-bottom: 3pt; text-align: justify; text-decoration: underline"><b><u>Exhibit</u></b></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center">4.1</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify">2014 Amended and Restated Stock Option Plan</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center">5.1</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify">Opinion of Borden Ladner Gervais LLP</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center">23.1</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify">Consent of Ernst &amp; Young LLP</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center">23.2</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify">Consent of McGovern, Hurley, Cunningham, LLP</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center">23.3</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify">Consent of Borden Ladner Gervais LLP (included in Exhibit 5.1)</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center">24.1</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify">Powers of Attorney (included on the Signatures page)</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 9. Undertakings.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">(a)&#9;The
undersigned Registrant hereby undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0; text-indent: 0.75in; text-align: justify">(1)&#9;To
file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0; text-indent: 1in; text-align: justify">(i)&#9;To
include any prospectus required by Section 10(a)(3) of the Securities Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0; text-indent: 1in; text-align: justify">(ii)&#9;To
reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set
forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in the volume of securities offered
(if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or
high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant
to Rule 424(b) if, in the aggregate, the changes in the volume and price represent no more than a 20% change in the maximum aggregate
offering price set forth in the &ldquo;Calculation of Registration Fee&rdquo; table in the effective registration statement; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0; text-indent: 1in; text-align: justify">(iii)&#9;To include any material information
with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such
information in the registration statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0; text-indent: 1in; text-align: justify"><I>provided, however,</I>
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section
13 or Section 15(d) of the Exchange Act that are incorporated by reference in this registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 1.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0; text-indent: 0.75in; text-align: justify">(2)&#9;That, for the purpose of determining
any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <I>bona fide
</I>offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0; text-indent: 0.75in; text-align: justify">(3)&#9;To remove from registration by
means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">(b)&#9;The undersigned Registrant hereby
undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&rsquo;s annual
report pursuant to Section 13(a) or Section 15(d) of the Exchange Act, (and, where applicable, each filing of an employee benefit
plan&rsquo;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration
statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide<I> </I>offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">(h)&#9;Insofar as indemnification for
liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant
pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that
a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by
a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted
by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless
in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
the question of whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">SIGNATURES</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">Pursuant to the requirements
of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this registration statement or amendment to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Toronto, Province of Ontario, Canada, on the 29th day of July,&nbsp;2015.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-variant: small-caps"><B>&#9;</B></FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left"><FONT STYLE="font-variant: small-caps"><B>CYNAPSUS THERAPEUTICS INC.</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: justify">(Registrant)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 55%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 5%; text-align: justify">By:</TD>
    <TD STYLE="width: 40%; text-align: justify; border-bottom: Black 1pt solid">/s/ Anthony Giovinazzo</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name: </TD>
    <TD>Anthony Giovinazzo</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Title: </TD>
    <TD>President and Chief Executive Officer</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>POWERS OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">Each person whose signature
appears below constitutes and appoints each of Anthony Giovinazzo and Andrew Williams with full power to act without the other,
his true and lawful attorneys-in-fact and agents, with full and several power of substitution, for him and in his name, place and
stead, in any and all capacities, to sign any or all amendments, including post-effective amendments to the registration statement,
new registration statements pursuant to General Instruction E of Form S-8 pertaining to the registration of additional securities
and post-effective amendments thereto, and any and all other documents in connection therewith to be filed with the Securities
and Exchange Commission granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every
act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as they or he
might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents as his or their substitute
or substitutes, may lawfully do or cause to be done by virtue hereof. This Power of Attorney may be executed in multiple counterparts,
each of which shall be deemed an original, but which taken together shall constitute one instrument.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0in; text-indent: 0.25in; text-align: justify">Pursuant to the requirements
of the Securities Act, this registration statement has been signed by the following persons in the capacities and on the date indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="vertical-align: bottom; width: 26%; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Signature
    </B></FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 5%; text-align: center; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 38%; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Title</B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 5%; text-align: center; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 26%; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Date</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">/s/
    Anthony Giovinazzo</FONT>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Anthony Giovinazzo</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">President, Chief Executive Officer
        and Director</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Principal Executive Officer)</P></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">July 29, 2015</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; border-bottom: Black 1pt solid">/s/ <FONT STYLE="font: 10pt Times New Roman, Times, Serif">Andrew
    Williams&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Andrew Williams</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Chief Operating Officer and Chief
        Financial Officer</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Principal Financial Officer and
        Principal Accounting Officer)</P></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">July 29, 2015</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">/s/
    <FONT STYLE="font-size: 10pt">Rochelle Stenzler</FONT></FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Rochelle
    Stenzler</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Director</FONT></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">July 29, 2015</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt; border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Tomer Gold</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Director</FONT></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">________, 2015</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">/s/
    <FONT STYLE="font-size: 10pt">Ronald Hosking</FONT></FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Ronald Hosking</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Director</FONT></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">July 29, 2015</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">/s/
    <FONT STYLE="font: 10pt Times New Roman, Times, Serif">Dr. Perry Molinoff</FONT>&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Dr. Perry Molinoff</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Director</FONT></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">July 29, 2015</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Ilan
    Oren</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;Director</FONT></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">_________, 2015</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt; border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">/s/
    <FONT STYLE="font-size: 10pt">Nan Hutchinson</FONT></FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Nan
    Hutchinson</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Director</FONT></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">July 29, 2015&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt; border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 10.1pt; text-align: center; text-indent: -10.1pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Tamar
    Howson</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Director</FONT></TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">_________, 2015&nbsp;</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AUTHORIZED REPRESENTATIVE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B></B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of Section&nbsp;6(a) of the Securities Act of 1933, as amended, the undersigned has signed this Registration
Statement, solely in the capacity of the duly authorized representative of Cynapsus Therapeutics Inc. in the United&nbsp;States,
on the 29th day of July, 2015.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="vertical-align: top; width: 60%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt; width: 30%; border-bottom: Black 1pt solid">/s/ Perry
Molinoff</TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Name:&nbsp;Perry
Molinoff</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Title:&nbsp;&nbsp;&nbsp;Director</FONT></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">EXHIBIT
INDEX</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD STYLE="width: 18%; padding-top: 3pt; padding-bottom: 3pt; text-align: center; font-size: 10pt; text-decoration: underline"><b><u>Exhibit Number</u></b></td>
    <TD STYLE="width: 82%; padding-top: 3pt; padding-bottom: 3pt; text-align: justify; font-size: 10pt; text-decoration: underline"><b><u>Exhibit</u></b></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center; font-size: 10pt">4.1</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify; font-size: 10pt">2014 Amended and Restated Stock Option Plan</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center; font-size: 10pt">5.1</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify; font-size: 10pt">Opinion of Borden Ladner Gervais LLP</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center; font-size: 10pt">23.1</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify; font-size: 10pt">Consent of Ernst &amp; Young LLP</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center; font-size: 10pt">23.2</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify; font-size: 10pt">Consent of McGovern, Hurley, Cunningham, LLP</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center; font-size: 10pt">23.3</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify; font-size: 10pt">Consent of Borden Ladner Gervais LLP (included in Exhibit 5.1)</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: center; font-size: 10pt">24.1</td>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; text-align: justify; font-size: 10pt">Powers of Attorney (included on the Signatures page)</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

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[{"type": "S-8", "sequence": "1", "filename": "v416180_s-8.htm", "description": "FORM S-8", "secsgml_size_bytes": 67218}]
{"company-data": {"conformed-name": "Cynapsus Therapeutics Inc.", "cik": "0001532079", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "Z4", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-205929", "film-number": "151012637"}, "business-address": {"street1": "828 RICHMOND STREET WEST", "city": "TORONTO", "state": "A6", "zip": "M6J 1C9", "phone": "416-703-2449"}, "mail-address": {"street1": "828 RICHMOND STREET WEST", "city": "TORONTO", "state": "A6", "zip": "M6J 1C9"}}
As filed with the Securities and Exchange Commission o
n
July 29, 2015
Registration No. 333-
UNITED STATES
SECURITIES
AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
CYNAPSUS THERAPEUTICS INC.
(Exact name of registrant as specified in its charter)
Canada
(State or other jurisdiction of incorporation or organization)
Not
    Applicable
(I.R.S. Employer Identification No.)
828 Richmond
        Street West,
Toronto, Ontario, M6J 1C9, Canada
(Address of Principal Executive Offices)
        (Zip Code)
2014 AMENDED AND
        RESTATED STOCK OPTION PLAN
(Full
title of the plan)
C T Corporation System
111 Eighth Avenue
New York, NY 10011
(Name and address of agent for service)
(212) 590-9070
(Telephone number, including area code, of agent for service)
The Commission is requested to mail signed
copies of all orders, notices and communications to:
Anthony Giovinazzo
Cynapsus Therapeutics Inc.
828 Richmond Street West
Toronto, Ontario
M6J 1C9 Canada
Telephone: (416) 703-2449
Thomas M. Rose, Esq.
Troutman Sanders LLP
401 9th Street, N.W., Suite 1000
Washington, D.C. 20004-2134
Telephone: (757) 687-7715
Facsimile: (757) 687-1529
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions
of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2
of the Exchange Act.
Large accelerated filer
o
Accelerated filer
o
Non-accelerated filer
x
(Do not check if a smaller reporting company)
Smaller reporting company
o
CALCULATION OF REGISTRATION FEE
Title of securities
to be registered (1)
Amount to be
registered (2)
Proposed
maximum offering price per share
Proposed
maximum
aggregate offering
price
Amount of registration fee
Common shares, no par value, subject to outstanding options
581,501 shares
$12.62 (3)(4)
$7,338,542.62
$852.74
Common shares, no par value, not subject to outstanding options
630,229
shares
$16.51 (5)
$10,405,080.79
$1,209.07
Total
1,211,730 shares
$
17,743,623.41
$
2,061.81
(1)
Common shares, without par value, of Cynapsus Therapeutics Inc. (the "
Registrant
")
pursuant to its 2014 Amended and Restated Stock Option Plan (the "
Plan
").
(2)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "
Securities
Act
"), this registration statement also covers an indeterminate number of additional shares that may be offered and issued
to prevent dilution resulting from stock splits, stock dividends or similar transactions as provided in the Plan.
(3)
Based on the weighted average exercise price of Cdn$16.32 of options granted under the Plan outstanding
as of July 28, 2015.
(4)
U.S. dollar amounts are calculated based on the Bank of Canada noon rate of exchange reported on July 28, 2015, which was Cdn$1.00=US$0.7732.
(5)
Calculated in accordance with Rule 457(c) and (h) based on the average of the high and low prices for the Registrant's
common shares reported on The NASDAQ Stock Market LLC on July 28, 2015, which was US$16.51 per share.
PART I.
	INFORMATION REQUIRED IN THE SECTION 10(
a) PROSPECTUS
Item
1.	Plan Information.*
Item
2.	Registrant Information and Employee Plan Annual Information.*
*
The
information required by Part I to be contained in the Section 10(a) prospectus is omitted from this registration statement in accordance
with the Note to Part I of Form S-8 and Rule 428.
PAR
T
II.	INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents,
which have been filed with the United States Securities and Exchange Commission (the "
Commission
"), are incorporated
herein by reference:
(a)
The Registrant's registration statement on Form F-10 (File No. 333-204226) (the "
Registration
Statement on Form F-10
"), initially filed with the Commission on May 15, 2015, as subsequently amended by any amendments
to such Registration Statement on Form F-10.
(b)
All other reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934,
as amended (the "
Exchange Act
"), since the end of the fiscal year covered by the Registration Statement on Form
F-10.
(c)
The description of the Registrant's securities contained in the registration statement on Form
8-A filed with the Commission on June 12, 2015 under Section 12(b) of the Exchange Act, including any amendment or report filed
for the purposes of updating such description.
In
addition, unless otherwise stated herein, all documents subsequently filed with the Commission by the Registrant pursuant to Sections
13(a), 13(c), 14 or 15(d) of the Exchange Act prior to the filing of a post-effective amendment to this registration statement
which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall
be deemed to be incorporated by reference in this registration statement and to be a part hereof from the date of filing of such
documents.
Any
statement contained in a document incorporated or deemed to be incorporated by reference in this document will be deemed to be
modified or superseded for purposes of this registration statement to the extent that a statement contained in this document or
in any other subsequently filed document which also is or is deemed to be incorporated by reference in this document modifies
or supersedes such statement. Any such statement so modified or superseded will not be deemed, except as so modified or superseded,
to constitute a part of this registration statement.
Item 4. Description of Securities.
Not applicable.
Item 5. Interests of Named Experts and Counsel.
None.
Item 6. Indemnification of Directors and Officers.
Under the
Canada
Business Corporations Act
, the Registrant may indemnify a director or officer of the Registrant, a former director or officer
of the Registrant or another individual who acts or acted at the Registrant's request as a director or officer, or an individual
acting in a similar capacity, of another entity, against all costs, charges and expenses, including an amount paid to settle an
action or satisfy a judgment, reasonably incurred by the individual in respect of any civil, criminal, administrative, investigative
or other proceeding in which the individual is involved because of that association with the Registrant or other entity and provided
that the director, officer or other individual acted honestly and in good faith with a view to the best interests of the Registrant,
or, as the case may be, to the best interests of the other entity for which the individual acted as a director or officer or in
a similar capacity at the Registrant's request and, in the case of a criminal or administrative action or proceeding that
is enforced by a monetary penalty, if the director, officer or other individual had reasonable grounds for believing that such
individual's conduct was lawful. Such indemnification may be made in connection with a derivative action only with court
approval. A director, officer or other individual referred to above is entitled to indemnification from the Registrant in respect
of all costs, charges and expenses reasonably incurred by the individual in connection with the defense of any civil, criminal,
administrative, investigative or other proceeding to which the individual is subject because of the individual's association
with the Registrant or other entity, as described above, if the individual was not judged by the court or other competent authority
to have committed any fault or omitted to do anything that the individual ought to have done and fulfilled the conditions set forth
above.
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The Registrant
has entered into agreements with certain of its directors and executive officers providing for indemnification against certain
expenses as described above. A policy of directors' and officers' liability insurance is maintained by the Registrant
which insures directors and officers for losses as a result of claims against the directors and officers of the Registrant in their
capacity as directors and officers and also reimburses the Registrant for payments made pursuant to the indemnity provisions under
the Registrant's by-laws and the
Canada Business Corporations Act
.
Insofar as the
indemnification for liabilities arising under the Securities Act may be permitted to directors, officers or persons controlling
the Registrant pursuant to the foregoing provisions, the Registrant has been informed that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.
Item 7. Exemption from Registration Claimed.
Not Applicable.
Item 8. Exhibits.
Exhibit Number
Exhibit
4.1
2014 Amended and Restated Stock Option Plan
5.1
Opinion of Borden Ladner Gervais LLP
23.1
Consent of Ernst & Young LLP
23.2
Consent of McGovern, Hurley, Cunningham, LLP
23.3
Consent of Borden Ladner Gervais LLP (included in Exhibit 5.1)
24.1
Powers of Attorney (included on the Signatures page)
Item 9. Undertakings.
(a)	The
undersigned Registrant hereby undertakes:
(1)	To
file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
(i)	To
include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)	To
reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set
forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in the volume of securities offered
(if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or
high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant
to Rule 424(b) if, in the aggregate, the changes in the volume and price represent no more than a 20% change in the maximum aggregate
offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement; and
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2
(iii)	To include any material information
with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such
information in the registration statement;
provided, however,
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section
13 or Section 15(d) of the Exchange Act that are incorporated by reference in this registration statement.
(2)	That, for the purpose of determining
any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(3)	To remove from registration by
means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)	The undersigned Registrant hereby
undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual
report pursuant to Section 13(a) or Section 15(d) of the Exchange Act, (and, where applicable, each filing of an employee benefit
plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration
statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide
offering thereof.
(h)	Insofar as indemnification for
liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant
pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that
a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by
a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted
by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless
in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
the question of whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.
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3
SIGNATURES
Pursuant to the requirements
of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this registration statement or amendment to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Toronto, Province of Ontario, Canada, on the 29th day of July, 2015.
CYNAPSUS THERAPEUTICS INC.
(Registrant)
By:
/s/ Anthony Giovinazzo
Name:
Anthony Giovinazzo
Title:
President and Chief Executive Officer
POWERS OF ATTORNEY
Each person whose signature
appears below constitutes and appoints each of Anthony Giovinazzo and Andrew Williams with full power to act without the other,
his true and lawful attorneys-in-fact and agents, with full and several power of substitution, for him and in his name, place and
stead, in any and all capacities, to sign any or all amendments, including post-effective amendments to the registration statement,
new registration statements pursuant to General Instruction E of Form S-8 pertaining to the registration of additional securities
and post-effective amendments thereto, and any and all other documents in connection therewith to be filed with the Securities
and Exchange Commission granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every
act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as they or he
might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents as his or their substitute
or substitutes, may lawfully do or cause to be done by virtue hereof. This Power of Attorney may be executed in multiple counterparts,
each of which shall be deemed an original, but which taken together shall constitute one instrument.
Pursuant to the requirements
of the Securities Act, this registration statement has been signed by the following persons in the capacities and on the date indicated.
Signature
Title
Date
/s/
    Anthony Giovinazzo
Anthony Giovinazzo
President, Chief Executive Officer
        and Director
(Principal Executive Officer)
July 29, 2015
/s/
Andrew
    Williams
Andrew Williams
Chief Operating Officer and Chief
        Financial Officer
(Principal Financial Officer and
        Principal Accounting Officer)
July 29, 2015
/s/
Rochelle Stenzler
Rochelle
    Stenzler
Director
July 29, 2015
Tomer Gold
Director
________, 2015
/s/
Ronald Hosking
Ronald Hosking
Director
July 29, 2015
/s/
Dr. Perry Molinoff
Dr. Perry Molinoff
Director
July 29, 2015
Ilan
    Oren
Director
_________, 2015
/s/
Nan Hutchinson
Nan
    Hutchinson
Director
July 29, 2015
Tamar
    Howson
Director
_________, 2015
AUTHORIZED REPRESENTATIVE
Pursuant
to the requirements of Section 6(a) of the Securities Act of 1933, as amended, the undersigned has signed this Registration
Statement, solely in the capacity of the duly authorized representative of Cynapsus Therapeutics Inc. in the United States,
on the 29th day of July, 2015.
/s/ Perry
Molinoff
Name: Perry
Molinoff
Title:   Director
EXHIBIT
INDEX
Exhibit Number
Exhibit
4.1
2014 Amended and Restated Stock Option Plan
5.1
Opinion of Borden Ladner Gervais LLP
23.1
Consent of Ernst & Young LLP
23.2
Consent of McGovern, Hurley, Cunningham, LLP
23.3
Consent of Borden Ladner Gervais LLP (included in Exhibit 5.1)
24.1
Powers of Attorney (included on the Signatures page)