<!--HTML document created with Certent Disclosure Management 21.3.1.1-->
<!--Created on: 11/19/2021 3:50:40 PM-->
<html>
	<head>
		<title>
			S-8
		</title>
	</head>
	<body><div style="margin-left:36pt;margin-right:36pt;">
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">As filed with the Securities and Exchange Commission on </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Novem</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">ber&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">22</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">, &nbsp;</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">2021</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 5pt">
			<font style="display: inline;font-family:Times New Roman;font-size:5pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;text-align:right;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Registration No. 333- </font>
		</p>
		<p style="margin:0pt 0pt 2pt;border-bottom:1pt solid #000000 ;line-height:normal;font-family:Arial;font-size: 5pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:4pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:18pt;">UNITED STATES </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:18pt;">SECURITIES AND EXCHANGE COMMISSION </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;">Washington, D.C. 20549 </font>
		</p>
		<p style="margin:0pt 0pt 2pt;border-bottom:1pt solid #000000 ;line-height:normal;text-align:center;font-family:Arial;font-size: 5pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:18pt;">FORM S-8&nbsp;</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;">REGISTRATION STATEMENT </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;text-transform:uppercase;color:#000000;">Under The Securities Act of 1933 </font>
		</p>
		<p style="margin:0pt 0pt 2pt;border-bottom:1pt solid #000000 ;line-height:normal;text-align:center;font-family:Arial;font-size: 5pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 24pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:24pt;">Pacific Biosciences of California, Inc. </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">(Exact name of registrant as specified in its charter) </font>
		</p>
		<p style="margin:0pt 0pt 2pt;border-bottom:1pt solid #000000 ;line-height:normal;text-align:center;font-family:Arial;font-size: 5pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="middle" style="width:43.34%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:19.22%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:37.44%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:43.34%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:8pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:19.22%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:37.44%;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:43.34%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Delaware</font></p>
				</td>
				<td valign="bottom" style="width:19.22%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:37.44%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">16-1590339</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:43.34%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">(State or other jurisdiction of</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">incorporation or organization)</font></p>
				</td>
				<td valign="bottom" style="width:19.22%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:37.44%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">(I.R.S. Employer</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Identification No.)</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 5pt">
			<font style="display: inline;font-size:5pt;">&#xFEFF;</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">1305 O&#x2019;Brien Drive </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Menlo Park, CA 94025 </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">(Address of Principal Executive Offices) (Zip Code) </font>
		</p>
		<p style="margin:0pt 0pt 2pt;border-bottom:1pt solid #000000 ;line-height:normal;text-align:center;font-family:Arial;font-size: 5pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:5pt;">&nbsp;&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 5pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;">Pacific Biosciences of California, Inc. 2020 Inducement Equity Incentive Plan</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:8pt;"> (Full title of the plan) </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Christian O. Henry</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Chief Executive Officer and President</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">1305 O&#x2019;Brien Drive </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Menlo Park, CA 94025 </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">(Name and address of agent for service) </font>
		</p>
		<p style="margin:6pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;"> (650) 521-8000</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:8pt;">(Telephone number, including area code, of agent for service) </font>
		</p>
		<p style="margin:6pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-style:italic;font-size:10pt;">Copies to: </font>
		</p>
		<p style="margin:6pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Donna M. Petkanics </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Andrew D. Hoffman </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Wilson Sonsini Goodrich &amp; Rosati, P.C. </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">650 Page Mill Road </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Palo Alto, CA 94304 </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">(650) 493-9300</font>
		</p>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#x201C;large accelerated filer,&#x201D; &#x201C;accelerated filer,&#x201D; &#x201C;smaller reporting company&#x201D; and &#x201C;emerging growth company&#x201D; in Rule 12b-2 of the Exchange Act. </font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="middle" style="width:16.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:00.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:13.18%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="bottom" style="width:46.40%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:19.90%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:00.90%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:01.90%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:16.88%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:00.88%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:13.18%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="bottom" style="width:46.40%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:19.90%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:00.90%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:01.90%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td colspan="3" valign="bottom" style="width:27.70%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Large accelerated filer</font></p>
				</td>
				<td valign="bottom" style="width:01.42%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.82%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Segoe UI Symbol;color:#000000;font-size:10pt;">&#x2610;</font></p>
				</td>
				<td valign="bottom" style="width:30.20%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="bottom" style="width:36.08%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Accelerated filer</font></p>
				</td>
				<td valign="bottom" style="width:00.90%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.90%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Segoe UI Symbol;color:#000000;font-size:10pt;">&#x2610;</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="3" valign="middle" style="width:27.70%;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:03.24%;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:66.28%;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:02.78%;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td colspan="3" valign="bottom" style="width:27.70%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Non-accelerated filer</font></p>
				</td>
				<td valign="bottom" style="width:01.42%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.82%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Segoe UI Symbol;color:#000000;font-size:10pt;">&#x2612;</font></p>
				</td>
				<td valign="bottom" style="width:30.20%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="bottom" style="width:36.08%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Smaller reporting company</font></p>
				</td>
				<td valign="bottom" style="width:00.90%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.90%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Segoe UI Symbol;color:#000000;font-size:10pt;">&#x2612;</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="3" valign="middle" style="width:27.70%;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:03.24%;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:66.28%;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:02.78%;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td colspan="3" valign="bottom" style="width:27.70%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:01.42%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.82%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:30.20%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="bottom" style="width:36.08%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Emerging growth company</font></p>
				</td>
				<td valign="bottom" style="width:00.90%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.90%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Segoe UI Symbol;color:#000000;font-size:10pt;">&#x2610;</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. </font><font style="display: inline;font-family:Segoe UI Symbol;font-size:10pt;">&#x2610;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:11pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt 0pt 8pt;line-height:107.92%;font-family:Arial;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt 0pt 8pt;line-height:107.92%;font-family:Arial;;font-size: 10pt"><font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;"></font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">CALCULATION OF REGISTRATION FEE </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:36.08%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:13.76%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:11.84%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:15.96%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:12.20%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:36.08%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:13.76%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:11.84%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:15.96%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:12.20%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td colspan="9" valign="top" style="width:100.00%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;border-top:1pt solid #000000 ;line-height:100%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:36.08%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Title of securities</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">to be registered</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:13.76%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Amount</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">to be</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">registered (1)</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:11.84%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Proposed</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">maximum</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">offering price</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">per share</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:15.96%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Proposed</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">maximum</font><br /><font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">aggregate</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">offering price</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:12.20%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Amount of</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">registration fee</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:36.08%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt 0pt 0pt 10pt;text-indent: -10pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Common stock, $0.001 par value per share, reserved for issuance pursuant to equity awards outstanding under the 2020 Inducement Equity Incentive Plan</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:13.76%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">360,000</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> (2)</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:11.84%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">$</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">2</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">5.92</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> (3)</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:15.96%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:7pt;">&nbsp;&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:7pt;">&nbsp;&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">$9,</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">331</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">,</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">20</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">0</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">.00</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:12.20%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">$8</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">65.00</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="9" valign="top" style="width:100.00%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;border-top:1pt solid #000000 ;line-height:100%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="9" valign="top" style="width:100.00%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;border-top:1pt solid #000000 ;line-height:100%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 1pt">
			<font style="display: inline;font-size:1pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:05.30%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(1)</font></p>
				</td>
				<td colspan="2" valign="top" style="width:94.70%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the &#x201C;Securities Act&#x201D;), this Registration Statement on Form S-8 (the &#x201C;Registration Statement&#x201D;) shall also cover any additional shares of common stock of Pacific Biosciences of California, Inc. (the &#x201C;Registrant&#x201D;) that may be issued pursuant to the 2020 Inducement Equity Incentive Plan (the &#x201C;Inducement Plan&#x201D;), by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an increase in the number of the outstanding shares of common stock of the Registrant.</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:05.30%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(2)</font></p>
				</td>
				<td colspan="2" valign="top" style="width:94.70%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Reflects 360,000 additional shares of common stock reserved for issuance pursuant to the Inducement Plan, as amended, as a result of an increase approved by Registrant&#x2019;s board of directors.</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="top" style="width:05.36%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(3)</font></p>
				</td>
				<td valign="top" style="width:94.64%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Estimated in accordance with Rule 457(c) and (h) under the Securities Act, solely for purposes of calculating the registration fee on the basis of </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">$2</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">5.92</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, the average of the high and low prices of Registrant</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2019;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">s common stock as reported on the NASDAQ Global Select Market on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">1</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">8</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="top" style="width:05.36%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:94.64%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
		</table></div><hr style="border-bottom-style:solid;width:100%;height:2.25pt; ;color:#a0a0a0" align="center"></hr>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">EXPLANATORY NOTE</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Pursuant to General Instruction E of Form S-8, the Registrant is filing this Registration Statement on Form S-8 with the U.S. Securities and Exchange Commission (the &#x201C;Commission&#x201D;) to register 360,000 additional shares of the Registrant&#x2019;s common stock&nbsp;&nbsp;reserved for issuance pursuant to the Inducement </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Plan</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">. This Registration Statement hereby incorporates by reference the contents of the Registrant&#x2019;s registration statement on Form S-8 filed with the Commission on </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">December&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">4, 2020 (Registration No. 333-251153) and the contents of the Registrant&#x2019;s registration statement on Form S-8 filed with the Commission on </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">April&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19, 2021 (Registration No. 333-255342).</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">PART I </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">INFORMATION REQUIRED IN THE PROSPECTUS </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">The documents containing the information specified in Item 1 and Item 2 of this Registration Statement, as amended, will be sent or given to employees, officers, directors or others as specified by Rule 428(b)(1) under the Securities Act of 1933, as amended (the </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x201C;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Securities Act</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x201D;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">). In accordance with the rules and regulations of the Commission and the instructions to the Registration Statement, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424. </font>
		</p>
		<p style="margin:24pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">PART II </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">INFORMATION REQUIRED IN REGISTRATION STATEMENT </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:531.90pt;margin-left:3pt;">
			<tr>
				<td valign="top" style="width:63.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:468.90pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:63.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 3.</font></p>
				</td>
				<td valign="top" style="width:468.90pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Incorporation of Documents by Reference. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pacific Biosciences of California, Inc. (the </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x201C;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Registrant</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x201D;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">) hereby incorporates by reference into this Registration Statement the following documents previously filed with the Commission: </font>
		</p>
		<p style="margin:12pt 0pt 0pt 36pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(1) The Registrant</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2019;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">s Annual Report on Form 10-K for its fiscal year ended </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">December&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">31, 2020, filed with the Commission on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">February&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26, 2021 pursuant to Section 13(a) of the Securities Exchange Act of 1934, as amended (the </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x201C;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Exchange Act</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x201D;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">); </font>
		</p>
		<p style="margin:12pt 0pt 0pt 36pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:12pt 0pt 0pt 36pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;;font-size: 10pt"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">(2) All other reports filed with the Commission pursuant to Sections 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Registrant</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2019;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">s Annual Report referred to in (1) above (other than the portions of these documents not deemed to be filed); and </font>
		</p>
		<p style="margin:12pt 0pt 0pt 36pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(3) The description of the Registrant</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2019;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">s Common Stock contained in the Registrant</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2019;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">s Registration Statement on Form 8-A (File No. 001-34899) filed with the Commission on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">October&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">6, 2010, pursuant to Section 12(b) of the Exchange Act, including any amendment or report filed for the purpose of updating such description. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">All documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference in this Registration Statement and to be part hereof from the date of filing of such documents. </font>
		</p>
		<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</font><font style="display: inline;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:531.05pt;margin-left:3pt;">
			<tr>
				<td valign="top" style="width:63.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:468.05pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:63.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 4.</font></p>
				</td>
				<td valign="top" style="width:468.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Description of Securities. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Not applicable. </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:534.55pt;margin-left:3pt;">
			<tr>
				<td valign="top" style="width:63.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:471.55pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:63.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 5.</font></p>
				</td>
				<td valign="top" style="width:471.55pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Interests of Named Experts and Counsel. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Not applicable. </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:11pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:532.55pt;margin-left:3pt;">
			<tr>
				<td valign="top" style="width:63.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:469.55pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:63.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 6.</font></p>
				</td>
				<td valign="top" style="width:469.55pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Indemnification of Directors and Officers.</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:6pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Section 145 of the Delaware General Corporation Law authorizes a corporation&#x2019;s board of directors to grant, and authorizes a court to award, indemnity to officers, directors and other corporate agents. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">As permitted by Section 102(b)(7) of the Delaware General Corporation Law, the Registrant&#x2019;s certificate of incorporation includes provisions that eliminate the personal liability of its directors for monetary damages for breach of their fiduciary duty as directors. To the extent Section 102(b)(7) is interpreted, or the Delaware General Corporation Law is amended, to allow similar protections for officers of a corporation, such provisions of the Registrant&#x2019;s certificate of incorporation shall also extend to those persons. </font>
		</p>
		<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">In addition, as permitted by Section 145 of the Delaware General Corporation Law, the bylaws of the Registrant to be effective upon completion of this offering provide that: </font>
		</p>
		<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font><a name="_Hlk87881965"></a></p>
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The Registrant shall indemnify its directors and officers for serving the Registrant in those capacities or for serving other business enterprises at the Registrant&#x2019;s request, to the fullest extent permitted by Delaware law. Delaware law provides that a corporation may indemnify such person if such person acted in good faith and in a manner such person reasonably believed to be in or not opposed to the best interests of the Registrant and, with respect to any criminal proceeding, had no reasonable cause to believe such person&#x2019;s conduct was unlawful. </font></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The Registrant may, in its discretion, indemnify employees and agents in those circumstances where indemnification is permitted by applicable law. </font></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The Registrant is required to advance expenses, as incurred, to its directors and officers in connection with defending a proceeding, except that such director or officer shall undertake to repay such advances if it is ultimately determined that such person is not entitled to indemnification. </font></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The Registrant will not be obligated pursuant to the bylaws to indemnify a person with respect to proceedings initiated by that person, except with respect to proceedings authorized by the Registrant&#x2019;s board of directors or brought to enforce a right to indemnification. </font></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The rights conferred in the bylaws are not exclusive, and the Registrant is authorized to enter into indemnification agreements with its directors, officers, employees and agents and to obtain insurance to indemnify such persons. </font></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The Registrant may not retroactively amend the bylaw provisions to reduce its indemnification obligations to directors, officers, employees and agents. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;;font-size: 12pt"><font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">The Registrant&#x2019;s policy is to enter into separate indemnification agreements with each of its directors and officers that provide the maximum indemnity allowed to directors and executive officers by Section 145 of the Delaware General Corporation Law and also provides for certain additional procedural protections.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">These indemnification provisions and the indemnification agreements entered into between the Registrant and its officers and directors may be sufficiently broad to permit indemnification of the Registrant&#x2019;s officers and directors for liabilities (including reimbursement of expenses incurred) arising under the Securities Act. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="top" style="width:09.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:459.10pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:09.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 7.</font></p>
				</td>
				<td valign="top" style="width:459.10pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Exemption from Registration Claimed. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Not applicable. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:540.30pt;margin-left:3pt;">
			<tr>
				<td valign="top" style="width:72.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:468.30pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:72.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 8.</font></p>
				</td>
				<td valign="top" style="width:468.30pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 7.4pt;line-height:105.83%;text-indent:7.4pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Exhibits. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 1pt">
			<font style="display: inline;font-size:1pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="middle" style="width:31.15pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:453.65pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:453.65pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Exhibit</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Number</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:453.65pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Description</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:8pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">4.1</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="http://www.sec.gov/Archives/edgar/data/1299130/000119312510221497/dex41.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Specimen Common Stock Certificate of Registrant (which is incorporated herein by reference to Exhibit 4.1 to the Registrant&#x2019;s Registration Statement on Form S-1, as amended (Registration No. 333-168858), as declared effective on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">October&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26, 2010) </font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">4.2</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="http://www.sec.gov/Archives/edgar/data/1299130/000129913020000008/pacb-20191231xex4_2.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Description of the Registrant&#x2019;s securities registered under Section 12 of the Exchange Act (which is incorporated herein by reference to Exhibit 4.2 to the Registrant&#x2019;s Form 10-K filed on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">February&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">28, 2020)</font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:9.65pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:9.65pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:9.65pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">4.3+</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="http://www.sec.gov/Archives/edgar/data/0001299130/000129913021000223/pacb-20211119xex10_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pacific Biosciences of California, Inc. 2020 Inducement Equity Incentive Plan and related forms of agreement thereunder (incorporated by reference from Exhibit 10.1 to the Registrant&#x2019;s Current Report on Form 8-K filed on November 19, 2021)</font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">5.1</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="pacb-20211119xex5_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Opinion of Wilson Sonsini Goodrich &amp; Rosati, Professional Corporation</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font></a><font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">23.1</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="pacb-20211119xex23_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Consent of Independent Registered Public Accounting Firm </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">23.2</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="pacb-20211119xex5_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Consent of Wilson Sonsini Goodrich &amp; Rosati, Professional Corporation (contained in Exhibit 5.1 hereto)</font></a><font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:4.25pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:4.25pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:4.25pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">23.3</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="pacb-20211119xex23_3.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Consent of KPMG LLP, Independent Auditors of Omniome, Inc.</font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">24.1</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="#POA"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Power of Attorney (contained on signature page hereto)</font></a><font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">+&nbsp;&nbsp;Indicates management contract or compensatory plan, contract or arrangement.</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:539.45pt;margin-left:3pt;">
			<tr>
				<td colspan="2" valign="top" style="width:67.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="top" style="width:468.95pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="top" style="width:67.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 9.</font></p>
				</td>
				<td colspan="2" valign="top" style="width:468.95pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Undertakings. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">A. The undersigned Registrant hereby undertakes: </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement: </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(i) To include any prospectus required by Section 10(a)(3) of the Securities Act; </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(ii) To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the </font>
		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;;font-size: 10pt"><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x201C;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Calculation of Registration Fee</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x201D;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> table in the effective registration statement; and </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-style:italic;color:#000000;font-size:10pt;">Provided, however</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, that paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </font><font style="display: inline;font-family:Times New Roman;font-style:italic;color:#000000;font-size:10pt;">bona fide</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> offering thereof. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. </font>
		</p>
		<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:11pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">B. The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2019;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2019;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </font><font style="display: inline;font-family:Times New Roman;font-style:italic;color:#000000;font-size:10pt;">bona fide</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> offering thereof. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">C. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 11pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;;font-size: 11pt"><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:11pt;"></font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">SIGNATURES</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Menlo Park, State of California, on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">. &nbsp;</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;line-height:100%;margin-bottom:0pt;margin-left:0pt;">
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:14.45pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:224.95pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:14.45pt;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:224.95pt;padding:0pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">PACIFIC BIOSCIENCES OF CALIFORNIA, INC.</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:14.45pt;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:224.95pt;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:14.45pt;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">By:</font></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:224.95pt;border-bottom:1pt solid #000000 ;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Michele Farmer</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:14.45pt;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:224.95pt;border-top:1pt solid #000000 ;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Michele Farmer</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:auto;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:14.45pt;padding:0pt;">
					<p style="margin:0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:224.95pt;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Vice President and Chief Accounting Officer</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:24pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">POWER OF ATTORNEY</font><a name="POA"></a>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Christian O. Henry, Susan G. Kim, Brett Atkins and Michele Farmer, jointly and severally, as his or her true and lawful attorneys-in-fact and agents with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign the Registration Statement on Form S-8 of Pacific Biosciences of California, Inc. and any or all amendments (including post-effective amendments) thereto, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or her or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof. </font>
		</p>
		<p style="margin:0pt 0pt 8pt;line-height:107.92%;font-family:Arial;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt 0pt 8pt;line-height:107.92%;font-family:Arial;;font-size: 10pt"><font style="display: inline;font-family:Times New Roman;font-size:10pt;"></font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:justify;text-justify:inter-ideograph;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated below: </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="middle" style="width:34.52%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">e</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:31.58%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:30.54%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:34.52%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:31.58%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:30.54%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Signature</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:31.58%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Title</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:30.54%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Date</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:34.52%;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:33.26%;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:32.22%;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;height:44.10pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Christian O. Henry</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Christian O. Henry</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;height:44.10pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:31.58%;height:44.10pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;">
						&nbsp;</p>
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director, Chief Executive Officer</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">and President (Principal Executive Officer)</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;height:44.10pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="middle" style="width:30.54%;height:44.10pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:34.52%;height:13.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:33.26%;height:13.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:32.22%;height:13.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:34.52%;height:31.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Susan G. Kim</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Susan G. Kim</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;height:31.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:31.58%;height:31.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Chief Financial Officer </font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(Principal Financial Officer)</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;height:31.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="middle" style="width:30.54%;height:31.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:34.52%;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;">
						&nbsp;</p>
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:33.26%;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:32.22%;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:34.52%;height:46.80pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Michele Farmer</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Michele Farmer</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;height:46.80pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:31.58%;height:46.80pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Vice President and Chief Accounting Officer (Principal Accounting Officer)</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;height:46.80pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="middle" style="width:30.54%;height:46.80pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ John F. Milligan</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">John F. Milligan</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:31.58%;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Chairman of the Board of Directors</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:30.54%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:31.58%;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:30.54%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ David Botstein</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">David Botstein</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:31.58%;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="middle" style="width:30.54%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;padding:0pt 3.6pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:31.58%;padding:0pt 3.6pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:30.54%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ William W. Ericson</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">William W. Ericson</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:31.58%;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="middle" style="width:30.54%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:34.52%;height:13.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="middle" style="width:01.68%;height:13.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:31.58%;height:13.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:01.68%;height:13.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:30.54%;height:13.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Hannah A. Valantine</font></p>
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Hannah A. Valantine</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:31.58%;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="middle" style="width:30.54%;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:34.52%;height:14.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="middle" style="width:01.68%;height:14.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:31.58%;height:14.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:01.68%;height:14.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:30.54%;height:14.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Randall S. Livingston</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Randall S. Livingston</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:31.58%;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:30.54%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:34.52%;height:14.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:33.26%;height:14.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:32.22%;height:14.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Marshall L. Mohr</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Marshall L. Mohr</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:31.58%;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="middle" style="width:30.54%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;height:36.90pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Kathy Ordo&#xF1;ez</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Kathy Ordo&#xF1;ez</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;height:36.90pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="middle" style="width:31.58%;height:36.90pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;height:36.90pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="middle" style="width:30.54%;height:36.90pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:34.52%;height:13.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:33.26%;height:13.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:32.22%;height:13.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:34.52%;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Lucy Shapiro</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Lucy Shapiro</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:31.58%;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="bottom" style="width:01.68%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="middle" style="width:30.54%;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">November&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">19</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:24pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr>
	</div></body>
</html>
[{"type": "S-8", "sequence": "1", "filename": "pacb-20211119xs8.htm", "description": "S-8", "secsgml_size_bytes": 149238}]
{"company-data": {"conformed-name": "PACIFIC BIOSCIENCES OF CALIFORNIA, INC.", "cik": "0001299130", "assigned-sic": "3826", "irs-number": "161590339", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-261251", "film-number": "211429793"}, "business-address": {"street1": "1305 O'BRIEN DRIVE", "city": "MENLO PARK", "state": "CA", "zip": "94025", "phone": "650-521-8000"}, "mail-address": {"street1": "1305 O'BRIEN DRIVE", "city": "MENLO PARK", "state": "CA", "zip": "94025"}, "former-company": [{"former-conformed-name": "PACIFIC BIOSCIENCES OF CALIFORNIA INC", "date-changed": "20050829"}, {"former-conformed-name": "NANOFLUIDICS INC", "date-changed": "20040729"}]}
S-8
As filed with the Securities and Exchange Commission on
Novem
ber
22
,
2021
﻿
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under The Securities Act of 1933
Pacific Biosciences of California, Inc.
(Exact name of registrant as specified in its charter)
﻿
Delaware
16-1590339
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
﻿
1305 O'Brien Drive
Menlo Park, CA 94025
(Address of Principal Executive Offices) (Zip Code)
Pacific Biosciences of California, Inc. 2020 Inducement Equity Incentive Plan
(Full title of the plan)
Christian O. Henry
Chief Executive Officer and President
1305 O'Brien Drive
Menlo Park, CA 94025
(Name and address of agent for service)
(650) 521-8000
(Telephone number, including area code, of agent for service)
Copies to:
Donna M. Petkanics
Andrew D. Hoffman
Wilson Sonsini Goodrich & Rosati, P.C.
650 Page Mill Road
Palo Alto, CA 94304
(650) 493-9300
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.
﻿
﻿
Large accelerated filer
☐
Accelerated filer
☐
﻿
Non-accelerated filer
☒
Smaller reporting company
☒
﻿
﻿
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.
☐
CALCULATION OF REGISTRATION FEE
﻿
﻿
Title of securities
to be registered
Amount
to be
registered (1)
Proposed
maximum
offering price
per share
Proposed
maximum
aggregate
offering price
Amount of
registration fee
Common stock, $0.001 par value per share, reserved for issuance pursuant to equity awards outstanding under the 2020 Inducement Equity Incentive Plan
360,000
(2)
$
2
5.92
(3)
$9,
331
,
20
0
.00
$8
65.00
﻿
﻿
(1)
Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (the "Registration Statement") shall also cover any additional shares of common stock of Pacific Biosciences of California, Inc. (the "Registrant") that may be issued pursuant to the 2020 Inducement Equity Incentive Plan (the "Inducement Plan"), by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an increase in the number of the outstanding shares of common stock of the Registrant.
(2)
Reflects 360,000 additional shares of common stock reserved for issuance pursuant to the Inducement Plan, as amended, as a result of an increase approved by Registrant's board of directors.
(3)
Estimated in accordance with Rule 457(c) and (h) under the Securities Act, solely for purposes of calculating the registration fee on the basis of
$2
5.92
, the average of the high and low prices of Registrant
'
s common stock as reported on the NASDAQ Global Select Market on
November
1
8
, 2021.
﻿
EXPLANATORY NOTE
﻿
Pursuant to General Instruction E of Form S-8, the Registrant is filing this Registration Statement on Form S-8 with the U.S. Securities and Exchange Commission (the "Commission") to register 360,000 additional shares of the Registrant's common stock  reserved for issuance pursuant to the Inducement
Plan
. This Registration Statement hereby incorporates by reference the contents of the Registrant's registration statement on Form S-8 filed with the Commission on
December
4, 2020 (Registration No. 333-251153) and the contents of the Registrant's registration statement on Form S-8 filed with the Commission on
April
19, 2021 (Registration No. 333-255342).
﻿
PART I
INFORMATION REQUIRED IN THE PROSPECTUS
The documents containing the information specified in Item 1 and Item 2 of this Registration Statement, as amended, will be sent or given to employees, officers, directors or others as specified by Rule 428(b)(1) under the Securities Act of 1933, as amended (the
"
Securities Act
"
). In accordance with the rules and regulations of the Commission and the instructions to the Registration Statement, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424.
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
﻿
Item 3.
Incorporation of Documents by Reference.
﻿
Pacific Biosciences of California, Inc. (the
"
Registrant
"
) hereby incorporates by reference into this Registration Statement the following documents previously filed with the Commission:
(1) The Registrant
'
s Annual Report on Form 10-K for its fiscal year ended
December
31, 2020, filed with the Commission on
February
26, 2021 pursuant to Section 13(a) of the Securities Exchange Act of 1934, as amended (the
"
Exchange Act
"
);
(2) All other reports filed with the Commission pursuant to Sections 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Registrant
'
s Annual Report referred to in (1) above (other than the portions of these documents not deemed to be filed); and
(3) The description of the Registrant
'
s Common Stock contained in the Registrant
'
s Registration Statement on Form 8-A (File No. 001-34899) filed with the Commission on
October
6, 2010, pursuant to Section 12(b) of the Exchange Act, including any amendment or report filed for the purpose of updating such description.
All documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference in this Registration Statement and to be part hereof from the date of filing of such documents.
﻿
Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
﻿
﻿
Item 4.
Description of Securities.
﻿
Not applicable.
﻿
Item 5.
Interests of Named Experts and Counsel.
﻿
Not applicable.
﻿
﻿
Item 6.
Indemnification of Directors and Officers.
﻿
Section 145 of the Delaware General Corporation Law authorizes a corporation's board of directors to grant, and authorizes a court to award, indemnity to officers, directors and other corporate agents.
As permitted by Section 102(b)(7) of the Delaware General Corporation Law, the Registrant's certificate of incorporation includes provisions that eliminate the personal liability of its directors for monetary damages for breach of their fiduciary duty as directors. To the extent Section 102(b)(7) is interpreted, or the Delaware General Corporation Law is amended, to allow similar protections for officers of a corporation, such provisions of the Registrant's certificate of incorporation shall also extend to those persons.
﻿
In addition, as permitted by Section 145 of the Delaware General Corporation Law, the bylaws of the Registrant to be effective upon completion of this offering provide that:
﻿
﻿
•
The Registrant shall indemnify its directors and officers for serving the Registrant in those capacities or for serving other business enterprises at the Registrant's request, to the fullest extent permitted by Delaware law. Delaware law provides that a corporation may indemnify such person if such person acted in good faith and in a manner such person reasonably believed to be in or not opposed to the best interests of the Registrant and, with respect to any criminal proceeding, had no reasonable cause to believe such person's conduct was unlawful.
•
The Registrant may, in its discretion, indemnify employees and agents in those circumstances where indemnification is permitted by applicable law.
•
The Registrant is required to advance expenses, as incurred, to its directors and officers in connection with defending a proceeding, except that such director or officer shall undertake to repay such advances if it is ultimately determined that such person is not entitled to indemnification.
•
The Registrant will not be obligated pursuant to the bylaws to indemnify a person with respect to proceedings initiated by that person, except with respect to proceedings authorized by the Registrant's board of directors or brought to enforce a right to indemnification.
•
The rights conferred in the bylaws are not exclusive, and the Registrant is authorized to enter into indemnification agreements with its directors, officers, employees and agents and to obtain insurance to indemnify such persons.
•
The Registrant may not retroactively amend the bylaw provisions to reduce its indemnification obligations to directors, officers, employees and agents.
﻿
The Registrant's policy is to enter into separate indemnification agreements with each of its directors and officers that provide the maximum indemnity allowed to directors and executive officers by Section 145 of the Delaware General Corporation Law and also provides for certain additional procedural protections.
These indemnification provisions and the indemnification agreements entered into between the Registrant and its officers and directors may be sufficiently broad to permit indemnification of the Registrant's officers and directors for liabilities (including reimbursement of expenses incurred) arising under the Securities Act.
﻿
﻿
Item 7.
Exemption from Registration Claimed.
﻿
Not applicable.
﻿
﻿
Item 8.
Exhibits.
﻿
﻿
﻿
﻿
Exhibit
Number
Description
﻿
4.1
Specimen Common Stock Certificate of Registrant (which is incorporated herein by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form S-1, as amended (Registration No. 333-168858), as declared effective on
October
26, 2010)
﻿
4.2
Description of the Registrant's securities registered under Section 12 of the Exchange Act (which is incorporated herein by reference to Exhibit 4.2 to the Registrant's Form 10-K filed on
February
28, 2020)
﻿
4.3+
Pacific Biosciences of California, Inc. 2020 Inducement Equity Incentive Plan and related forms of agreement thereunder (incorporated by reference from Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on November 19, 2021)
﻿
5.1
Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation
﻿
23.1
Consent of Independent Registered Public Accounting Firm
﻿
23.2
Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (contained in Exhibit 5.1 hereto)
﻿
23.3
Consent of KPMG LLP, Independent Auditors of Omniome, Inc.
﻿
24.1
Power of Attorney (contained on signature page hereto)
﻿
+  Indicates management contract or compensatory plan, contract or arrangement.
﻿
﻿
Item 9.
Undertakings.
A. The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i) To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii) To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the
"
Calculation of Registration Fee
"
table in the effective registration statement; and
(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement.
Provided, however
, that paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
﻿
B. The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant
'
s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan
'
s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
C. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Menlo Park, State of California, on
November
19
, 2021
.
﻿
﻿
﻿
PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
﻿
﻿
By:
/s/ Michele Farmer
﻿
Michele Farmer
﻿
Vice President and Chief Accounting Officer
﻿
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Christian O. Henry, Susan G. Kim, Brett Atkins and Michele Farmer, jointly and severally, as his or her true and lawful attorneys-in-fact and agents with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign the Registration Statement on Form S-8 of Pacific Biosciences of California, Inc. and any or all amendments (including post-effective amendments) thereto, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or her or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated below:
e
﻿
Signature
Title
Date
﻿
/s/
Christian O. Henry
Christian O. Henry
Director, Chief Executive Officer
and President (Principal Executive Officer)
November
19
, 2021
﻿
/s/ Susan G. Kim
Susan G. Kim
Chief Financial Officer
(Principal Financial Officer)
November
19
, 2021
﻿
/s/ Michele Farmer
Michele Farmer
Vice President and Chief Accounting Officer (Principal Accounting Officer)
November
19
, 2021
/s/ John F. Milligan
John F. Milligan
Chairman of the Board of Directors
November
19
, 2021
﻿
/s/ David Botstein
David Botstein
Director
November
19
, 2021
﻿
/s/ William W. Ericson
William W. Ericson
Director
November
19
, 2021
﻿
/s/ Hannah A. Valantine
Hannah A. Valantine
Director
November
19
, 2021
﻿
/s/ Randall S. Livingston
Randall S. Livingston
Director
November
19
, 2021
﻿
/s/ Marshall L. Mohr
Marshall L. Mohr
Director
November
19
, 2021
/s/ Kathy Ordoñez
Kathy Ordoñez
Director
November
19
, 2021
﻿
/s/ Lucy Shapiro
Lucy Shapiro
Director
November
19
, 2021
﻿