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<P ALIGN="CENTER"><FONT SIZE=5><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>  </B></FONT><FONT SIZE=2><B>Washington, D.C. 20549  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>FORM S-8<BR>  </B></FONT><FONT SIZE=2><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933  </B></FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=5><B>AXONYX&nbsp;INC.<BR>  </B></FONT><FONT SIZE=2>(Name of Small Business Issuer in Its Charter) </FONT></P>

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<TD WIDTH="49%" ALIGN="CENTER"><FONT SIZE=2><B>NEVADA<BR> </B></FONT><FONT SIZE=2>(State or Other Jurisdiction of<BR>
Incorporation or Organization)</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="49%" ALIGN="CENTER"><FONT SIZE=2><B>86-0883978<BR> </B></FONT><FONT SIZE=2>(I.R.S. Employer<BR>
Identification No.)</FONT></TD>
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<TD WIDTH="49%" ALIGN="CENTER" VALIGN="TOP"><FONT SIZE=2>&nbsp;<BR></FONT> <FONT SIZE=2><B>825 THIRD AVENUE, 40<SUP>th</SUP> FLOOR,<BR>
NEW&nbsp;YORK, NEW&nbsp;YORK<BR> </B></FONT><FONT SIZE=2>(Address of Principal Executive Offices)</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="49%" ALIGN="CENTER" VALIGN="TOP"><FONT SIZE=2>&nbsp;<BR></FONT> <FONT SIZE=2><B>10022<BR> </B></FONT><FONT SIZE=2>(Zip Code)</FONT></TD>
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<P ALIGN="CENTER"><FONT SIZE=5><B>AXONYX&nbsp;INC. 1998 STOCK OPTION PLAN<BR>
AXONYX&nbsp;INC. 2000 STOCK OPTION PLAN<BR>  </B></FONT><FONT SIZE=2>(Full Title of the Plans) </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2><B>Marvin S. Hausman, M.D., President&nbsp;&amp; Chief Executive Officer<BR>
825 Third Avenue<BR>
40<SUP>th</SUP> Floor<BR>
New York, New York 10022<BR>
(212)&nbsp;688-4770<BR>  </B></FONT><FONT SIZE=2>(Name, Address and Telephone Number of Agent for Service) </FONT></P>

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<P ALIGN="CENTER"><FONT SIZE=2><B>CALCULATION OF REGISTRATION FEE  </B></FONT></P>

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<TH WIDTH="38%" ALIGN="CENTER"><FONT SIZE=1><B>Title of Each Class<BR>
of Securities to be Registered</B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="14%" ALIGN="CENTER"><FONT SIZE=1><B>Amount to be<BR>
Registered(1)</B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="17%" ALIGN="CENTER"><FONT SIZE=1><B>Proposed Maximum<BR>
Offering Price<BR>
per Share(2)</B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="14%" ALIGN="CENTER"><FONT SIZE=1><B>Proposed Maximum<BR>
Aggregate<BR>
Offering Price</B></FONT><BR></TH>
<TH WIDTH="1%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="14%" ALIGN="CENTER"><FONT SIZE=1><B>Amount of<BR>
Registration Fee</B></FONT><BR></TH>
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<TD WIDTH="38%"><FONT SIZE=2>Common Stock, par value $0.001</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>2,395,900</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="17%" ALIGN="CENTER"><FONT SIZE=2>$7.00 - $18.62</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>$24,085,454</FONT></TD>
<TD WIDTH="1%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="14%" ALIGN="CENTER"><FONT SIZE=2>$6,358.56</FONT></TD>
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<DL compact>
<DT><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>This
Registration Statement shall also cover any additional shares of Common Stock which become issuable under the 1998 and 2000 Stock Option Plans of Axonyx&nbsp;Inc. by reason
of any stock dividend, stock split, recapitalization or other similar transaction effected without the Registrant's receipt of consideration which results in an increase in the number of outstanding
shares of the Registrant's Common Stock.
<BR><BR></FONT></DD><DT><FONT SIZE=2>(2)</FONT></DT><DD><FONT SIZE=2>Calculated
solely for purposes of this offering under Rule&nbsp;457(h) of the Securities Act of 1933, as amended, on the basis of (i)&nbsp;the actual exercise prices of $7.00
per share for 5,000 shares; $7.20 per share for 20,000 shares; $8.00 per share for 2,500 shares; $8.12 per share for 1,500 shares; $8.125 per share for 100,000 shares; $8.50 per share for 20,000
shares; $9.00 per share for 7,500 shares; $9.50 per share for 150,000 shares; $9.69 per share for 2,000 shares; $10.00 per share for 7,500 shares; $11.00 per share for 178,000 shares; $11.50 per share
for 280,000 shares; and $18.62 per share for 600 shares with respect to outstanding options; and (ii)&nbsp;the average of the closing bid and ask prices of the Common Stock on October&nbsp;11,
2000 of $9.94 with respect to 621,300 shares of Common Stock subject to future grants of options under the 1998 Stock Option Plan and 1,000,000 shares of Common Stock subject to future grants of
options under the 2000 Stock Option Plan. </FONT></DD></DL>
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<H2><FONT SIZE=2> </FONT></H2>
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<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="ja1887_part_i_information_requ__ja102263"> </A></FONT> <FONT SIZE=2><B>PART I<BR>       INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS         </B></FONT></P>

<P><FONT SIZE=2><B>Item 1.&nbsp;&nbsp;Plan Information.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;See Item 2 below. </FONT></P>

<P><FONT SIZE=2><B>Item 2.&nbsp;&nbsp;Registrant Information and Employee Plan Annual Information.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The documents containing the information specified in Part&nbsp;I, Items 1 and 2 will be delivered to each of the participants in accordance with
Form&nbsp;S-8 and Rule&nbsp;428 promulgated under the Securities Act of 1933. The participants shall be provided with a written statement notifying them that upon written or oral
request they will be provided, without charge, (a)&nbsp;the documents incorporated by reference in Item 3 of Part&nbsp;II of the registration statement, and (b)&nbsp;other documents required to
be delivered pursuant to Rule&nbsp;428(b). The statement will inform the participants that these documents are incorporated by reference in the Section&nbsp;10(a) prospectus, and shall include the
address and telephone number to which the request is to be directed. </FONT></P>

<BR>
<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="ja1887_part_ii_information_not_required_in_prospectus"> </A></FONT> <FONT SIZE=2><B>PART II<BR>       INFORMATION NOT REQUIRED IN PROSPECTUS         </B></FONT></P>


<P><FONT SIZE=2><B>Item 3.&nbsp;&nbsp;Incorporation of Documents by Reference.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Axonyx&nbsp;Inc. hereby incorporates by reference into this Registraton Statement the following documents previously filed with the Securities and Exchange
Commission ("SEC"): </FONT></P>

<UL>
<DL compact>
<DT><FONT SIZE=2>1.</FONT></DT><DD><FONT SIZE=2>The
Annual Report on Form&nbsp;10-KSB for the year ended December&nbsp;31, 1999, filed with the SEC on March&nbsp;13, 2000;
<BR><BR></FONT></DD><DT><FONT SIZE=2>2.</FONT></DT><DD><FONT SIZE=2>The
Quarterly Reports on Form&nbsp;10-QSB for the quarters ended March&nbsp;31, 2000 and June&nbsp;30, 2000, filed with the SEC on May&nbsp;15, 2000 and on
August&nbsp;14, 2000, respectively; and
<BR><BR></FONT></DD><DT><FONT SIZE=2>3.</FONT></DT><DD><FONT SIZE=2>The
description of our common stock set forth in the Amendment No.&nbsp;1, Registration Statement on Form&nbsp;10-SB, filed with the SEC on August&nbsp;10, 1999. </FONT></DD></DL>
</UL>

<P><FONT SIZE=2><B>Item 4.&nbsp;&nbsp;Description of Securities.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>

<P><FONT SIZE=2><B>Item 5.&nbsp;&nbsp;Interests of Named Experts and Counsel.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>


<P><FONT SIZE=2><B>Item 6.&nbsp;&nbsp;Indemnification of Directors and Officers.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The Nevada General Corporation Law allows us to indemnify our officers and directors from liability incurred by reason of the fact that he or she is or was an
officer or director of the corporation. We may authorize such indemnification if we determine that it is proper under the circumstances. This
determination can be authorized based on a vote of our stockholders, by a majority vote of a quorum of directors who were not parties to the relevant legal action, or under certain circumstances, by
independent legal counsel in a written opinion. The indemnification can include, but is not limited to, reimbursement of all fees, including amounts paid in settlement and attorney's fees actually and
reasonably incurred, in connection with the defense or settlement of any action or suit by the officer or director. The Restated Articles of Incorporation and the By-Laws of
Axonyx&nbsp;Inc. contain provisions relating to indemnification of officers and directors. Those provisions appear below. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>2</FONT></P>

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<P><FONT SIZE=2>
&nbsp;&nbsp;&nbsp;&nbsp;Article&nbsp;XI of the Articles of Incorporation of Axonyx&nbsp;Inc. provides as follows: </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
personal liability of the directors of the corporation is hereby eliminated to the fullest extent permitted by the provisions of the Nevada Revised Statutes of the State of
Nevada, as the same may be amended and supplemented. The corporation shall indemnify any person who incurs expenses by reason of the fact that he or she is or was an officer, director, employee or
agent of the corporation. This indemnification shall be mandatory on all circumstances in which indemnification is permitted by law. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Article&nbsp;VI
of the By-Laws of Axonyx&nbsp;Inc. provides as follows: </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
corporation shall, to the maximum extent and in the manner permitted by the Nevada Revised Statutes, indemnify each of its directors and officers against expenses (including
attorneys' fees), judgments, fines, settlements, and other amounts actually and reasonably incurred in connection with any proceeding, arising by reason of the fact that such person is or was an agent
of the corporation. For purposes of this Section&nbsp;6.1, a "director" or "officer" of the corporation includes any person (i)&nbsp;who is or was a director or officer of the corporation,
(ii)&nbsp;who is or was serving at the request of the corporation as a director or officer of another corporation, partnership, joint venture, trust or other enterprise, or (iii)&nbsp;who was a
director or officer of a corporation which was a predecessor corporation of the corporation or of another enterprise at the request of such predecessor corporation. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
corporation shall have the power, to the maximum extent and in the manner permitted by the Nevada Revised Statutes, to indemnify each of its employees and agents (other than
directors and officers) against expenses (including attorneys' fees), judgments, fines, settlements, and other amounts actually and reasonably incurred in connection with any proceeding, arising by
reason of the fact that such person is or was an agent of the corporation. For purposes of this Section&nbsp;6.2, an "employee" or
"agent" of the corporation (other than a director or officer) includes any person (i)&nbsp;who is or was an employee or agent of the corporation, (ii)&nbsp;who is or was serving at the request of
the corporation as an employee or agent of another corporation, partnership, joint venture, trust or other enterprise, or (iii)&nbsp;who was an employee or agent of a corporation which was a
predecessor corporation of the corporation or of another enterprise at the request of such predecessor corporation. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The
corporation may purchase and maintain insurance on behalf of any person who is or was a director, officer, employee or agent of the corporation, or is or was serving at the
request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise against any liability asserted against him and
incurred by him in any such capacity, or arising out of his status as such, whether or not the corporation would have the power to indemnify him against such liability under the provisions of the
Nevada Revised Statutes. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;We
have purchased and maintained insurance covering our officers and directors for the purpose of covering indemnification expenses. </FONT></P>


<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;At
present, there is no pending litigation or proceeding involving a director, officer, employee or agent of our company as to which indemnification is being sought. </FONT></P>

<P><FONT SIZE=2><B>Item 7.&nbsp;&nbsp;Exemption from Registration Claimed.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>

<P><FONT SIZE=2><B>Item 8.&nbsp;&nbsp;Exhibits.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;The Exhibits required by Item 601 of Regulation&nbsp;S-B, and an index thereto, are attached. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>3</FONT></P>

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<P><FONT SIZE=2><B>Item 9.&nbsp;&nbsp;Undertakings.  </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;We
hereby undertake to: </FONT></P>

<UL>
<DL compact>
<DT><FONT SIZE=2>(1)</FONT></DT><DD><FONT SIZE=2>File,
during any period in which it offers or sells are being made, a post-effective amendment to this registration statement to include any additional or changed
material information on the plan of distribution.
<BR><BR></FONT></DD><DT><FONT SIZE=2>(2)</FONT></DT><DD><FONT SIZE=2>For
determining liability under the Securities Act, treat each post-effective amendment as a new registration statement relating to the securities offered, and the
offering of securities at that time to be the initial bona fide offering.
<BR><BR></FONT></DD><DT><FONT SIZE=2>(3)</FONT></DT><DD><FONT SIZE=2>File&nbsp;a
post-effective amendment to remove from registration any of the securities that remain unsold at the termination of the offering. </FONT></DD></DL>
</UL>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;We
hereby undertake that, for the purposes of determining any liability under the Securities Act, each filing of our annual report pursuant to Section&nbsp;13(a)
of Section&nbsp;15(d) of the Securities Exchange Act of 1934 that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Insofar
as indemnification for liabilities arising under the Securities Act may be permitted to our directors, officers and controlling persons pursuant to the
foregoing provisions, or otherwise, we have been advised that, in the opinion of the Securities and Exchange Commission, such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than our payment of expenses incurred or paid by a director, officer or controlling
person in the successful defense of any action, suit or proceeding) is asserted by our directors, officers or controlling persons in connection with the securities being registered, we will, unless in
the opinion of our counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question of whether indemnification is against public policy as
expressed in the Act and will be governed by the final adjudication of such issue. </FONT></P>

<P ALIGN="CENTER"><FONT SIZE=2>4</FONT></P>

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<H2><FONT SIZE=2> </FONT></H2>
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<P ALIGN="CENTER"><FONT SIZE=2><A
NAME="jc1887_signatures"> </A></FONT> <FONT SIZE=2><B>SIGNATURES         </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended, we certify that we have reasonable grounds to believe that Axonyx&nbsp;Inc. meets all
of the requirements for filling on Form&nbsp;S-8 and we have authorized this registration statement to be signed on our behalf by the undersigned, thereunto duly authorized, in New York,
New York, on October&nbsp;5, 2000. </FONT></P>

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<TD WIDTH="48%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="50%" COLSPAN=2><FONT SIZE=2>Axonyx Inc.</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="48%"><FONT SIZE=2>&nbsp;<BR>
&nbsp;</FONT></TD>
<TD WIDTH="2%"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;<BR>
By:</FONT></TD>
<TD WIDTH="46%" ALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
/s/&nbsp;</FONT><FONT SIZE=2>MARVIN S. HAUSMAN</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Marvin S. Hausman, M.D.</FONT><FONT SIZE=2><I><BR>
President&nbsp;&amp; Chief Executive Officer</I></FONT></TD>
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<BR>
<P ALIGN="CENTER"><FONT SIZE=2><I> <A NAME="jc1887_power_of_attorney"> </A> </I></FONT><FONT SIZE=2><B>POWER OF ATTORNEY         </B></FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Albert D. Angel and Marvin S. Hausman, M.D. and
each of them acting alone, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any
and all capacities, to sign any or all amendments (including post-effective amendments) to this registration statement on Form&nbsp;S-8, and to file the same, with all
exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them
acting alone, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or
could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or each of them acting alone, or his substitute or substitutes, may lawfully do
or cause to be done by virtue hereof. </FONT></P>

<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, this registration statement on Form&nbsp;S-8 has been signed by the following persons in the capacities and
on the dates indicated. </FONT></P>

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<TH WIDTH="45%" ALIGN="CENTER"><FONT SIZE=1><B>Signature</B></FONT><HR NOSHADE></TH>
<TH WIDTH="2%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="30%" ALIGN="CENTER"><FONT SIZE=1><B>Title</B></FONT><HR NOSHADE></TH>
<TH WIDTH="2%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="21%" ALIGN="CENTER"><FONT SIZE=1><B>Date</B></FONT><HR NOSHADE></TH>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=1><B>&nbsp;<BR> </B></FONT><FONT SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="30%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
&nbsp;</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
&nbsp;</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
/s/&nbsp;</FONT><FONT SIZE=2>ALBERT D. ANGEL</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Albert D. Angel</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="30%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
Chairman of the Board</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
October 11, 2000</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
/s/&nbsp;</FONT><FONT SIZE=2>MARVIN S. HAUSMAN</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Marvin S. Hausman, M.D.</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="30%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
President&nbsp;&amp; Chief Executive Officer and Director (Principal Executive Officer)</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
October 11, 2000</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
/s/&nbsp;</FONT><FONT SIZE=2>ABRAHAM E. COHEN</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Abraham E. Cohen</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="30%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
October 12, 2000</FONT></TD>
</TR>
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<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
/s/&nbsp;</FONT><FONT SIZE=2>MICHAEL M. STRAGE</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Michael M. Strage</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="30%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
Vice President, Treasurer and Director (Principal Financial&nbsp;&amp; Accounting Officer)</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
October 12, 2000</FONT></TD>
</TR>
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<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
/s/&nbsp;</FONT><FONT SIZE=2>MICHAEL R. ESPEY</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Michael R. Espey</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="30%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
Vice President, Secretary, General Counsel and Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
October 12, 2000</FONT></TD>
</TR>
<TR VALIGN="BOTTOM">
<TD WIDTH="45%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
/s/&nbsp;</FONT><FONT SIZE=2>CHRISTOPHER WETHERHILL</FONT><FONT SIZE=2>&nbsp;&nbsp;&nbsp;</FONT><HR NOSHADE><FONT SIZE=2> Christopher Wetherhill</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="30%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
Director</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" ALIGN="CENTER" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
October 12, 2000</FONT></TD>
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&nbsp;</FONT></TD>
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<TD WIDTH="30%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
&nbsp;</FONT></TD>
<TD WIDTH="2%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="21%" VALIGN="CENTER"><FONT SIZE=2>&nbsp;<BR>
&nbsp;</FONT></TD>
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<TH WIDTH="9%" ALIGN="LEFT"><FONT SIZE=1><B>Exhibit No.<BR> </B></FONT><HR NOSHADE></TH>
<TH WIDTH="4%"><FONT SIZE=1>&nbsp;</FONT></TH>
<TH WIDTH="88%" ALIGN="CENTER"><FONT SIZE=1><B>Description of Document</B></FONT><HR NOSHADE></TH>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2>&nbsp;<BR>
3.1</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;<BR>*</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>&nbsp;<BR>
Restated Articles of Incorporation dated June 23, 2000</FONT></TD>
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<TR VALIGN="TOP">
<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2>&nbsp;<BR>
3.2</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;<BR>**</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>&nbsp;<BR>
By-Laws</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2>&nbsp;<BR>
5.1</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>&nbsp;<BR>
Opinion of Gordon &amp; Silver, Ltd. regarding legality of the Common Stock being registered.</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2>&nbsp;<BR>
23.1</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>&nbsp;<BR>
Consent of Richard A. Eisner &amp; Company LLP</FONT></TD>
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<TR VALIGN="TOP">
<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2>&nbsp;<BR>
23.2</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>&nbsp;<BR>
Consent of Gordon &amp; Silver, Ltd. (Reference is made to Exhibit 5.1.)</FONT></TD>
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<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2>&nbsp;<BR>
24.1</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>&nbsp;<BR>
Power of Attorney. (See signature page.)</FONT></TD>
</TR>
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99.1</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;<BR>***</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>&nbsp;<BR>
Axonyx Inc. 1998 Stock Option Plan</FONT></TD>
</TR>
<TR VALIGN="TOP">
<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2>&nbsp;<BR>
99.2</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
<TD WIDTH="88%"><FONT SIZE=2>&nbsp;<BR>
Axonyx Inc. 2000 Stock Option Plan</FONT></TD>
</TR>
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<TD WIDTH="9%" ALIGN="RIGHT"><FONT SIZE=2>&nbsp;<BR>
&nbsp;</FONT></TD>
<TD WIDTH="4%"><FONT SIZE=2>&nbsp;<BR>&nbsp;</FONT></TD>
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&nbsp;</FONT></TD>
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<DT><FONT SIZE=2>*</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to the corresponding exhibit in the Form&nbsp;10-QSB previously filed by the Company on August&nbsp;14, 2000.
<BR><BR></FONT></DD><DT><FONT SIZE=2>**</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to the corresponding exhibit in the Registration Statement on Form&nbsp;10-SB previously filed by the Company on March&nbsp;17, 1999 (File
no.&nbsp;000-25571).
<BR><BR></FONT></DD><DT><FONT SIZE=2>***</FONT></DT><DD><FONT SIZE=2>Incorporated
by reference to the corresponding exhibit in the Form&nbsp;10-KSB previously filed by the Company on March&nbsp;13, 2000. </FONT></DD></DL>
<HR NOSHADE>
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<FONT SIZE=2><A HREF="#ja1887_part_i_information_requ__ja102263">PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</A></FONT><BR>
<FONT SIZE=2><A HREF="#ja1887_part_ii_information_not_required_in_prospectus">PART II INFORMATION NOT REQUIRED IN PROSPECTUS</A></FONT><BR>

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<FONT SIZE=2><A HREF="#jc1887_signatures">SIGNATURES</A></FONT><BR>
<FONT SIZE=2><A HREF="#jc1887_power_of_attorney">POWER OF ATTORNEY</A></FONT><BR>
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[{"type": "S-8", "sequence": "1", "filename": "a2027952zs-8.htm", "description": "FORM S-8", "secsgml_size_bytes": 30139}]
{"company-data": {"conformed-name": "AXONYX INC", "cik": "0001070698", "assigned-sic": "2834", "irs-number": "860883978", "state-of-incorporation": "NV", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-48088", "film-number": "741560"}, "business-address": {"street1": "750 LEXINTTON AVE", "street2": "STE 1400", "city": "NEW YORK", "state": "NY", "zip": "10022", "phone": "2126884770"}, "mail-address": {"street1": "750 LEXINGTON AVE", "street2": "STE 1400", "city": "NEW YORK", "state": "NY", "zip": "10022"}}
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
AXONYX INC.
(Name of Small Business Issuer in Its Charter)
NEVADA
(State or Other Jurisdiction of
Incorporation or Organization)
86-0883978
(I.R.S. Employer
Identification No.)
825 THIRD AVENUE, 40
th
FLOOR,
NEW YORK, NEW YORK
(Address of Principal Executive Offices)
10022
(Zip Code)
AXONYX INC. 1998 STOCK OPTION PLAN
AXONYX INC. 2000 STOCK OPTION PLAN
(Full Title of the Plans)
Marvin S. Hausman, M.D., President & Chief Executive Officer
825 Third Avenue
40
th
Floor
New York, New York 10022
(212) 688-4770
(Name, Address and Telephone Number of Agent for Service)
CALCULATION OF REGISTRATION FEE
Title of Each Class
of Securities to be Registered
Amount to be
Registered(1)
Proposed Maximum
Offering Price
per Share(2)
Proposed Maximum
Aggregate
Offering Price
Amount of
Registration Fee
Common Stock, par value $0.001
2,395,900
$7.00 - $18.62
$24,085,454
$6,358.56
(1)
This
Registration Statement shall also cover any additional shares of Common Stock which become issuable under the 1998 and 2000 Stock Option Plans of Axonyx Inc. by reason
of any stock dividend, stock split, recapitalization or other similar transaction effected without the Registrant's receipt of consideration which results in an increase in the number of outstanding
shares of the Registrant's Common Stock.
(2)
Calculated
solely for purposes of this offering under Rule 457(h) of the Securities Act of 1933, as amended, on the basis of (i) the actual exercise prices of $7.00
per share for 5,000 shares; $7.20 per share for 20,000 shares; $8.00 per share for 2,500 shares; $8.12 per share for 1,500 shares; $8.125 per share for 100,000 shares; $8.50 per share for 20,000
shares; $9.00 per share for 7,500 shares; $9.50 per share for 150,000 shares; $9.69 per share for 2,000 shares; $10.00 per share for 7,500 shares; $11.00 per share for 178,000 shares; $11.50 per share
for 280,000 shares; and $18.62 per share for 600 shares with respect to outstanding options; and (ii) the average of the closing bid and ask prices of the Common Stock on October 11,
2000 of $9.94 with respect to 621,300 shares of Common Stock subject to future grants of options under the 1998 Stock Option Plan and 1,000,000 shares of Common Stock subject to future grants of
options under the 2000 Stock Option Plan.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Item 1.  Plan Information.
See Item 2 below.
Item 2.  Registrant Information and Employee Plan Annual Information.
The documents containing the information specified in Part I, Items 1 and 2 will be delivered to each of the participants in accordance with
Form S-8 and Rule 428 promulgated under the Securities Act of 1933. The participants shall be provided with a written statement notifying them that upon written or oral
request they will be provided, without charge, (a) the documents incorporated by reference in Item 3 of Part II of the registration statement, and (b) other documents required to
be delivered pursuant to Rule 428(b). The statement will inform the participants that these documents are incorporated by reference in the Section 10(a) prospectus, and shall include the
address and telephone number to which the request is to be directed.
PART II
INFORMATION NOT REQUIRED IN PROSPECTUS
Item 3.  Incorporation of Documents by Reference.
Axonyx Inc. hereby incorporates by reference into this Registraton Statement the following documents previously filed with the Securities and Exchange
Commission ("SEC"):
1.
The
Annual Report on Form 10-KSB for the year ended December 31, 1999, filed with the SEC on March 13, 2000;
2.
The
Quarterly Reports on Form 10-QSB for the quarters ended March 31, 2000 and June 30, 2000, filed with the SEC on May 15, 2000 and on
August 14, 2000, respectively; and
3.
The
description of our common stock set forth in the Amendment No. 1, Registration Statement on Form 10-SB, filed with the SEC on August 10, 1999.
Item 4.  Description of Securities.
Not applicable.
Item 5.  Interests of Named Experts and Counsel.
Not applicable.
Item 6.  Indemnification of Directors and Officers.
The Nevada General Corporation Law allows us to indemnify our officers and directors from liability incurred by reason of the fact that he or she is or was an
officer or director of the corporation. We may authorize such indemnification if we determine that it is proper under the circumstances. This
determination can be authorized based on a vote of our stockholders, by a majority vote of a quorum of directors who were not parties to the relevant legal action, or under certain circumstances, by
independent legal counsel in a written opinion. The indemnification can include, but is not limited to, reimbursement of all fees, including amounts paid in settlement and attorney's fees actually and
reasonably incurred, in connection with the defense or settlement of any action or suit by the officer or director. The Restated Articles of Incorporation and the By-Laws of
Axonyx Inc. contain provisions relating to indemnification of officers and directors. Those provisions appear below.
2
Article XI of the Articles of Incorporation of Axonyx Inc. provides as follows:
The
personal liability of the directors of the corporation is hereby eliminated to the fullest extent permitted by the provisions of the Nevada Revised Statutes of the State of
Nevada, as the same may be amended and supplemented. The corporation shall indemnify any person who incurs expenses by reason of the fact that he or she is or was an officer, director, employee or
agent of the corporation. This indemnification shall be mandatory on all circumstances in which indemnification is permitted by law.
Article VI
of the By-Laws of Axonyx Inc. provides as follows:
The
corporation shall, to the maximum extent and in the manner permitted by the Nevada Revised Statutes, indemnify each of its directors and officers against expenses (including
attorneys' fees), judgments, fines, settlements, and other amounts actually and reasonably incurred in connection with any proceeding, arising by reason of the fact that such person is or was an agent
of the corporation. For purposes of this Section 6.1, a "director" or "officer" of the corporation includes any person (i) who is or was a director or officer of the corporation,
(ii) who is or was serving at the request of the corporation as a director or officer of another corporation, partnership, joint venture, trust or other enterprise, or (iii) who was a
director or officer of a corporation which was a predecessor corporation of the corporation or of another enterprise at the request of such predecessor corporation.
The
corporation shall have the power, to the maximum extent and in the manner permitted by the Nevada Revised Statutes, to indemnify each of its employees and agents (other than
directors and officers) against expenses (including attorneys' fees), judgments, fines, settlements, and other amounts actually and reasonably incurred in connection with any proceeding, arising by
reason of the fact that such person is or was an agent of the corporation. For purposes of this Section 6.2, an "employee" or
"agent" of the corporation (other than a director or officer) includes any person (i) who is or was an employee or agent of the corporation, (ii) who is or was serving at the request of
the corporation as an employee or agent of another corporation, partnership, joint venture, trust or other enterprise, or (iii) who was an employee or agent of a corporation which was a
predecessor corporation of the corporation or of another enterprise at the request of such predecessor corporation.
The
corporation may purchase and maintain insurance on behalf of any person who is or was a director, officer, employee or agent of the corporation, or is or was serving at the
request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise against any liability asserted against him and
incurred by him in any such capacity, or arising out of his status as such, whether or not the corporation would have the power to indemnify him against such liability under the provisions of the
Nevada Revised Statutes.
We
have purchased and maintained insurance covering our officers and directors for the purpose of covering indemnification expenses.
At
present, there is no pending litigation or proceeding involving a director, officer, employee or agent of our company as to which indemnification is being sought.
Item 7.  Exemption from Registration Claimed.
Not applicable.
Item 8.  Exhibits.
The Exhibits required by Item 601 of Regulation S-B, and an index thereto, are attached.
3
Item 9.  Undertakings.
(a) We
hereby undertake to:
(1)
File,
during any period in which it offers or sells are being made, a post-effective amendment to this registration statement to include any additional or changed
material information on the plan of distribution.
(2)
For
determining liability under the Securities Act, treat each post-effective amendment as a new registration statement relating to the securities offered, and the
offering of securities at that time to be the initial bona fide offering.
(3)
File a
post-effective amendment to remove from registration any of the securities that remain unsold at the termination of the offering.
(b) We
hereby undertake that, for the purposes of determining any liability under the Securities Act, each filing of our annual report pursuant to Section 13(a)
of Section 15(d) of the Securities Exchange Act of 1934 that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c) Insofar
as indemnification for liabilities arising under the Securities Act may be permitted to our directors, officers and controlling persons pursuant to the
foregoing provisions, or otherwise, we have been advised that, in the opinion of the Securities and Exchange Commission, such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than our payment of expenses incurred or paid by a director, officer or controlling
person in the successful defense of any action, suit or proceeding) is asserted by our directors, officers or controlling persons in connection with the securities being registered, we will, unless in
the opinion of our counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question of whether indemnification is against public policy as
expressed in the Act and will be governed by the final adjudication of such issue.
4
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, we certify that we have reasonable grounds to believe that Axonyx Inc. meets all
of the requirements for filling on Form S-8 and we have authorized this registration statement to be signed on our behalf by the undersigned, thereunto duly authorized, in New York,
New York, on October 5, 2000.
Axonyx Inc.
By:
/s/
MARVIN S. HAUSMAN
Marvin S. Hausman, M.D.
President & Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Albert D. Angel and Marvin S. Hausman, M.D. and
each of them acting alone, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any
and all capacities, to sign any or all amendments (including post-effective amendments) to this registration statement on Form S-8, and to file the same, with all
exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them
acting alone, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or
could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or each of them acting alone, or his substitute or substitutes, may lawfully do
or cause to be done by virtue hereof.
Pursuant
to the requirements of the Securities Act of 1933, this registration statement on Form S-8 has been signed by the following persons in the capacities and
on the dates indicated.
Signature
Title
Date
/s/
ALBERT D. ANGEL
Albert D. Angel
Chairman of the Board
October 11, 2000
/s/
MARVIN S. HAUSMAN
Marvin S. Hausman, M.D.
President & Chief Executive Officer and Director (Principal Executive Officer)
October 11, 2000
/s/
ABRAHAM E. COHEN
Abraham E. Cohen
Director
October 12, 2000
/s/
MICHAEL M. STRAGE
Michael M. Strage
Vice President, Treasurer and Director (Principal Financial & Accounting Officer)
October 12, 2000
/s/
MICHAEL R. ESPEY
Michael R. Espey
Vice President, Secretary, General Counsel and Director
October 12, 2000
/s/
CHRISTOPHER WETHERHILL
Christopher Wetherhill
Director
October 12, 2000
Exhibit No.
Description of Document
3.1
*
Restated Articles of Incorporation dated June 23, 2000
3.2
**
By-Laws
5.1
Opinion of Gordon & Silver, Ltd. regarding legality of the Common Stock being registered.
23.1
Consent of Richard A. Eisner & Company LLP
23.2
Consent of Gordon & Silver, Ltd. (Reference is made to Exhibit 5.1.)
24.1
Power of Attorney. (See signature page.)
99.1
***
Axonyx Inc. 1998 Stock Option Plan
99.2
Axonyx Inc. 2000 Stock Option Plan
*
Incorporated
by reference to the corresponding exhibit in the Form 10-QSB previously filed by the Company on August 14, 2000.
**
Incorporated
by reference to the corresponding exhibit in the Registration Statement on Form 10-SB previously filed by the Company on March 17, 1999 (File
no. 000-25571).
***
Incorporated
by reference to the corresponding exhibit in the Form 10-KSB previously filed by the Company on March 13, 2000.
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PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
PART II INFORMATION NOT REQUIRED IN PROSPECTUS
SIGNATURES
POWER OF ATTORNEY