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<P align="center"><FONT size="2">As filed with the Securities and
Exchange Commission on June 27, 2001 &nbsp;&nbsp;&nbsp;&nbsp; <I>Registration No.&nbsp;333-_________</I></FONT>

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<P align="center"><FONT size="4"><B>SECURITIES AND EXCHANGE COMMISSION</B></FONT>
<DIV align="center"><FONT size="3">Washington, DC 20549</FONT></DIV>

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<P align="center"><FONT size="4"><B>FORM S-8</B></FONT>
<DIV align="center"><FONT size="3">REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</FONT></DIV>


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<P align="center"><FONT size="4"><B>Epimmune Inc.</B></FONT>
<DIV align="center"><FONT size="2">(Exact name of registrant as specified in its charter)</FONT></DIV>

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        <TD width="44%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="51%">&nbsp;</TD>
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        <TD align="center" valign="top"><FONT size="2">Delaware<BR>
(State of Incorporation)</FONT></TD>
        <TD></TD>
        <TD  align="center" valign="top"><FONT size="2">
33-0245076<BR>
(I.R.S. Employer Identification No.)</FONT></TD>
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<P align="center"><FONT size="2"><B>5820 Nancy Ridge Drive<BR>
San Diego, CA 92121<BR>
(858)&nbsp;860-2500</B><BR>
(Address of principal executive offices)</FONT>

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<P align="center"><FONT size="2"><B>2001 Employee Stock Purchase Plan</B><BR>
(Full title of the plans)</FONT>

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<P align="center"><FONT size="2"><B>Emile Loria, M.D.<BR>
President and Chief Executive Officer<BR>
Epimmune Inc.<BR>
5820 Nancy Ridge Drive<BR>
San Diego, CA 92121<BR>
(858)&nbsp;860-2500</B><BR>
(Name, address, including zip code, and telephone number, including area code, of agent for service)</FONT>

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<P align="center"><FONT size="2"><B>Copies to:<BR>
L. Kay Chandler, Esq.<BR>
COOLEY GODWARD LLP<BR>
4635 Executive Drive, Suite&nbsp;1100<BR>
San Diego, CA 92121<BR>
(858)&nbsp;550-6000</B></FONT>

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<P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B></FONT>

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        <TD></TD>
        <TD></TD>
        <TD></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2">Proposed Maximum</FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2">Proposed Maximum</FONT></TD>
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<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2">Title of Securities</FONT></TD>
        <TD></TD>
        <TD></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2">Offering</FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2">Aggregate</FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2">Amount of</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2">to be Registered</FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2">Amount to be Registered</FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2">Price per Share (1)</FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2">Offering Price (1)</FONT></TD>
        <TD></TD>
        <TD nowrap align="center" colspan="3"><FONT size="2">Registration Fee</FONT></TD>
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<TR valign="bottom">
        <TD valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock, par value
$0.01 per share</FONT></DIV></TD>
        <TD></TD>
        <TD align="center" valign="bottom"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
300,000 shares
</FONT></DIV></TD>
        <TD></TD>
        <TD nowrap align="right" valign="bottom"><FONT size="2">$</FONT></TD>
        <TD align="right" valign="bottom"><FONT size="2">3.297
</FONT></TD>
        <TD valign="top"></TD>
        <TD></TD>
        <TD nowrap align="right" valign="bottom"><FONT size="2">$</FONT></TD>
        <TD align="right" valign="bottom"><FONT size="2">989,062.50
</FONT></TD>
        <TD valign="top"></TD>
        <TD></TD>
        <TD nowrap align="right" valign="bottom"><FONT size="2">$</FONT></TD>
        <TD align="right" valign="bottom"><FONT size="2">248</FONT></TD>
        <TD></TD>
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      <TD width="1%" align="left"><FONT size="2">(1)</FONT></TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="96%"><FONT size="2">Estimated solely for the purpose of calculating the amount of the
registration fee pursuant to Rule&nbsp;457(h)(1) of the Securities Act of 1933,
as amended, (the &#147;Securities Act&#148;). The price per share and aggregate
offering price are based upon the average of the high and low prices of
Registrant&#146;s Common Stock on June&nbsp;21, 2001, as reported on the Nasdaq
National Market.</FONT></TD>
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<A name="toc"><DIV align="CENTER"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD colspan="9"><A HREF="#000">INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</A></TD></TR>
<TR><TD colspan="9"><A HREF="#001">INDEMNIFICATION OF DIRECTORS AND OFFICERS</A></TD></TR>
<TR><TD colspan="9"><A HREF="#002">EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">UNDERTAKINGS</A></TD></TR>
<TR><TD colspan="9"><A HREF="#004">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#005">POWER OF ATTORNEY</A></TD></TR>
<TR><TD colspan="9"><A HREF="#006">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="a73753orex5-1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a73753orex23-1.txt">EXHIBIT 23.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a73753orex99-1.txt">Exhibit 99.1</A></TD></TR>
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<P align="center"><FONT size="2"><B>INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We are a reporting company and file annual, quarterly and current reports,
proxy statements and other information with the SEC. You may read and copy
these reports, proxy statements and other information at the SEC&#146;s public
reference rooms in Washington, D.C., New York, NY and Chicago, IL. You can
request copies of these documents by writing to the SEC and paying a fee for
the copying cost. Please call the SEC at 1-800-SEC-0330 for more information
about the operation of the public reference rooms. Our SEC filings are also
available at the SEC&#146;s Web site at &#147;http://www.sec.gov&#148;.
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The SEC allows us to incorporate by reference information that we file
with them, which means that we can disclose important information to you by
referring you to those documents. The information incorporated by reference is
an important part of this prospectus, and information that we file later with
the SEC will automatically update and supersede this information. We
incorporate by reference the documents listed below:
</FONT>

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        <TD width="3%">&nbsp;</TD>
        <TD width="1%" align="left"><FONT size="2">&#149;</FONT></TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="93%"><FONT size="2">Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 2000;</FONT></TD>
</TR>
<TR>
        <TD>&nbsp;</TD>
</TR>
<TR valign="top">
        <TD width="3%">&nbsp;</TD>
        <TD width="1%" align="left"><FONT size="2">&#149;</FONT></TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="93%"><FONT size="2">Proxy Statement on Schedule&nbsp;14A filed April&nbsp;27, 2001;</FONT></TD>
</TR>
<TR>
        <TD>&nbsp;</TD>
</TR>
<TR valign="top">
        <TD width="3%">&nbsp;</TD>
        <TD width="1%" align="left"><FONT size="2">&#149;</FONT></TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="93%"><FONT size="2">Quarterly Report on Form&nbsp;10-Q for the quarter ended March&nbsp;31, 2001; and</FONT></TD>
</TR>
<TR>
        <TD>&nbsp;</TD>
</TR>
<TR valign="top">
        <TD width="3%">&nbsp;</TD>
        <TD width="1%" align="left"><FONT size="2">&#149;</FONT></TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="93%"><FONT size="2">Our registration statement on Form&nbsp;8-A, as amended, which
includes a description of our common stock.</FONT></TD>
</TR>
</TABLE>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents that we subsequently file prior to the
filing of a post-effective amendment, which indicates that all securities
offered have been sold or which deregisters all securities then remaining
unsold, shall be deemed to be incorporated by reference herein and to be a part
hereof from the date of the filing of such reports and documents.
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We hereby undertake to provide without charge to each person to whom a
copy of this prospectus is delivered, upon written or oral request of any such
person, a copy of any and all of the information that has been or may be
incorporated by reference in this prospectus, other than exhibits to such
documents. Requests for such copies should be directed to the attention of our
Investor Relations department, at
</FONT>


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        <TD width="3%">&nbsp;</TD>
        <TD width="97%" align="left"><FONT size="2">Epimmune Inc.<BR>
5820 Nancy Ridge Drive<BR>
San Diego, CA 92121<BR>
(858)860-2500</FONT></TD>
</TR>
</TABLE>


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<P align="center"><FONT size="2"><B>INDEMNIFICATION OF DIRECTORS AND OFFICERS</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Our Certificate of Incorporation and Bylaws include provisions to (i)
eliminate the personal liability of our directors for monetary damages
resulting from breaches of their fiduciary duty to the extent permitted by
Section&nbsp;102(b)(7) of the Delaware General Corporation Law (&#147;DGCL&#148;) and (ii)
require us to indemnify our directors and officers to the fullest extent
permitted by applicable law, including circumstances in which indemnification
is otherwise discretionary. Pursuant to Section&nbsp;145 of the DGCL, a corporation
generally has the power to indemnify its present and former directors,
officers, employees and agents against expenses incurred by them in connection
with any suit to which they are or are threatened to be made, a party by reason
of their serving in such positions so long as they acted in good faith and in a
manner they reasonably believed to be in or not opposed to, the best interests
of the corporation and with respect to any criminal action, they had no
reasonable cause to believe their conduct was unlawful. We believe that these
provisions are necessary to attract and retain qualified persons as directors
and officers. These provisions do not eliminate the directors&#146; or officers&#146;
duty of care, and, in appropriate circumstances, equitable remedies such as
injunctive or other forms of non-monetary relief will remain available under
the DGCL. In addition, each director will continue to be subject to liability
pursuant to Section&nbsp;174 of the DGCL, for breach of the director&#146;s duty of
loyalty to us, for acts or omissions not in good faith or involving
</FONT>



<DIV>&nbsp;</DIV>
<P align="center"><FONT size="2">2</FONT>
<DIV>&nbsp;</DIV>


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<P><FONT size="2">intentional misconduct, for knowing violations of law, for acts or
omissions that the director believes to be contrary to our best interests or
our stockholders, for any transaction from which the director derived an
improper personal benefit, for acts or omissions involving a reckless disregard
for the director&#146;s duty to us or our stockholders when the director was aware
or should have been aware of a risk of serious injury to us or our
stockholders, for acts or omission that constitute an unexcused pattern of
inattention that amounts to an abdication of the director&#146;s duty to us or our
stockholders, for improper transactions between the director and us and for
improper loans to directors and officers. The provision also does not affect a
director&#146;s responsibilities under any other law, such as the federal securities
law or state or federal environmental laws.
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We have entered into indemnity agreements with each of our directors and
executive officers that require us to indemnify such persons against expenses,
judgments, fines, settlements and other amounts incurred (including expenses of
a derivative action) in connection with any proceeding, whether actual or
threatened, to which any such person may be made a party by reason of the fact
that such person is or was one of our directors or executive officers or a
director or executive officer of any of our affiliated enterprises, provided
such person acted in good faith and in a manner such person reasonably believed
to be in or not opposed to the best interests of us and, with respect to any
criminal proceeding, had no reasonable cause to believe his conduct was
unlawful. The indemnification agreements also set forth certain procedures that
will apply in the event of a claim for indemnification thereunder.
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;At present, there is no pending litigation or proceeding involving our
directors or officers as to which indemnification is being sought nor are we
aware of any threatened litigation that may result in claims for
indemnification by any officer or director.
</FONT>



<DIV>&nbsp;</DIV>
<P align="center"><FONT size="2">3</FONT>
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<P align="center"><FONT size="2"><B>EXHIBITS</B></FONT>

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        <TD width="6%">&nbsp;</TD>
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        <TD width="1%">&nbsp;</TD>
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        <TD width="1%">&nbsp;</TD>
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        <TD nowrap align="center"><FONT size="2"><B>Exhibit</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"><B>Number</B></FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="center"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">5.1</FONT></DIV></TD>
        <TD></TD>
        <TD  align="left" valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
Opinion of Cooley Godward LLP.</FONT></DIV></TD>
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<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top" align="center"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">23.1</FONT></DIV></TD>
        <TD></TD>
        <TD  align="left" valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
Consent of Ernst &#38; Young LLP.</FONT></DIV></TD>
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<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top" align="center"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">23.2</FONT></DIV></TD>
        <TD></TD>
        <TD  align="left" valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
Consent of Cooley Godward LLP is contained in Exhibit&nbsp;5.1 to this Registration Statement.</FONT></DIV></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top" align="center"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">24.1</FONT></DIV></TD>
        <TD></TD>
        <TD  align="left" valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
Power of Attorney is contained on the signature pages.</FONT></DIV></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top" align="center"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">99.1</FONT></DIV></TD>
        <TD></TD>
        <TD  align="left" valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
Epimmune Inc. 2001 Employee Stock Purchase Plan.</FONT></DIV></TD>
</TR>
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<P align="center"><FONT size="2"><B>UNDERTAKINGS</B></FONT>

<P>
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<TR valign="top">
        <TD width="1%" align="left"><FONT size="2"><B>1.</B></FONT></TD>
        <TD width="2%">&nbsp;</TD>
        <TD width="97%"><FONT size="2">The undersigned registrant hereby undertakes:</FONT></TD>
</TR>
</TABLE>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(a)&nbsp;</B>To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(i)&nbsp;&nbsp;&nbsp;</B>To include any prospectus required by section 10(a)(3) of the
Securities Act;
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(ii)&nbsp;&nbsp;</B>To reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that
which was registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule&nbsp;424(b) (&#167; 230.424(b) of this
chapter) if, in the aggregate, the changes in volume and price represent no
more than a 20% change in the maximum aggregate offering price set forth in the
&#147;Calculation of Registration Fee&#148; table in the effective registration
statement.
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(iii)&nbsp;</B>To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement;
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Provided, however, </I>that paragraphs (a)(i) and (a)(ii) do not apply if the
information required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed by the issuer pursuant to
section 13 or section 15(d) of the Exchange Act that are incorporated by
reference herein.
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(b)&nbsp;</B>That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered herein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>(c)&nbsp;</B>To remove from registration by means of a post-effective amendment any
of the securities being registered, which remain, unsold at the termination of
the offering.
</FONT>

<P>
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<TR valign="top">
        <TD width="1%" align="left"><FONT size="2"><B>2.</B></FONT></TD>
        <TD width="2%">&nbsp;</TD>
        <TD width="97%"><FONT size="2">The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant&#146;s annual report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of
the Exchange Act (and, where applicable, each filing of an employee
benefit plan&#146;s annual report pursuant to section 15(d) of the Exchange
Act) that is incorporated by reference in the Registration Statement shall
be</FONT></TD>
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<DIV>&nbsp;</DIV>
<P align="center"><FONT size="2">4</FONT>
<DIV>&nbsp;</DIV>


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<P>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
        <TD width="1%" align="left"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="2%">&nbsp;</TD>
        <TD width="97%"><FONT size="2">deemed to be a new registration statement relating to the securities
offered herein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.</FONT></TD>
</TR>
<TR>
        <TD>&nbsp;</TD>
</TR>
<TR valign="top">
        <TD width="1%" align="left"><FONT size="2"><B>3.</B></FONT></TD>
        <TD width="2%">&nbsp;</TD>
        <TD width="97%"><FONT size="2">Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as
expressed in the Securities Act and is, therefore, unenforceable. In the
event that a claim for indemnification against such liabilities (other
than the payment by the registrant of expenses incurred or paid by a
director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities
being registered, the registrant will, unless in the opinion of its
counsel the matter has been settled by controlling precedent, submit to a
court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the
Securities Act and will be governed by the final adjudication of such
issue.</FONT></TD>
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<DIV>&nbsp;</DIV>
<P align="center"><FONT size="2">5</FONT>
<DIV>&nbsp;</DIV>


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<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="004"></A></DIV>


<P align="center"><FONT size="2"><B>SIGNATURES</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form&nbsp;S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of San Diego, State of California, on June&nbsp;26,
2001.
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%" align="center">
<TR valign="bottom">
        <TD width="8%">&nbsp;</TD>
        <TD width="31%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="51%">&nbsp;</TD>
</TR>

<TR valign="bottom">
        <TD>&nbsp;</TD>
        <TD></TD>
        <TD align="left" valign="top" colspan="2"><FONT size="2"><B>Epimmune Inc.</B>
</FONT></TD>
</TR>
<TR valign="bottom">
        <TD>&nbsp;</TD>
        <TD></TD>
        <TD></TD>
</TR>
<TR valign="bottom">
        <TD>&nbsp;</TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">By:</FONT></TD>
        <TD  align="left" valign="top"><FONT size="2">/s/ Emile Loria, M.D.</FONT></TD>
</TR>

<TR valign="bottom">
        <TD>&nbsp;</TD>
        <TD></TD>
        <TD></TD>
        <TD align="left" valign="top"><FONT size="2"><HR size="1" noshade></FONT></TD>
</TR>
<TR valign="bottom">
        <TD>&nbsp;</TD>
        <TD></TD>
        <TD></TD>
        <TD align="left" valign="top"><FONT size="2">Emile Loria, M.D.<BR>President and Chief Executive Officer</FONT></TD>
</TR>
</TABLE>
</CENTER>
<!-- link1 "POWER OF ATTORNEY" -->
<DIV align="left"><A NAME="005"></A></DIV>


<P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>KNOW ALL PERSONS BY THESE PRESENTS</B>, that each person whose signature
appears below constitutes and appoints Emile Loria, M.D. and Robert J. De
Vaere, and each or any one of them, his true and lawful attorney-in-fact and
agent, with full power of substitution and resubstitution, for him and in his
name, place and stead, in any and all capacities, to sign any and all
amendments (including post-effective amendments) to this Registration
Statement, and to file the same, with all exhibits thereto, and other documents
in connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in connection therewith, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that said attorneys-in-fact and agents, or any of them, or their or his
substitutes or substitute, may lawfully do or cause to be done by virtue
hereof.
</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%" align="center">
<TR valign="bottom">
        <TD width="34%">&nbsp;</TD>
        <TD width="4%">&nbsp;</TD>
        <TD width="45%">&nbsp;</TD>
        <TD width="4%">&nbsp;</TD>
        <TD width="13%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"><B>Signature</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"><B>Title</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"><B>Date</B></FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>

<TR>
<TD>&nbsp;</TD>
</TR>


<TR valign="bottom">
        <TD valign="top" align="left"><FONT size="2">/s/ Emile Loria, M.D.</FONT></TD>
        <TD></TD>
        <TD valign="top" align="left"><FONT size="2">President, Chief Executive Officer and Director</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">June&nbsp;26, 2001</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2"><HR size="1" noshade>
EMILE LORIA, M.D.</FONT></TD>
        <TD></TD>
        <TD valign="top" align="left"><FONT size="2"><I>(Principal
Executive Officer)</I></FONT></TD>
</TR>

<TR>
<TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="left"><FONT size="2">/s/ Robert J. De Vaere</FONT></TD>
        <TD></TD>
        <TD valign="top" align="left"><FONT size="2">Vice President, Finance and Chief Financial Officer</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">June&nbsp;26, 2001</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2"><HR size="1" noshade>
ROBERT J. DE VAERE</FONT></TD>
        <TD></TD>
        <TD valign="top" align="left"><FONT size="2"><I>(Principal Financial and Accounting
Officer)</I></FONT></TD>
</TR>

<TR>
<TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ Howard E. Greene, Jr.</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">June&nbsp;26, 2001</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2"><HR size="1" noshade></FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">HOWARD E. GREENE, JR</FONT></TD>
</TR>

<TR>
<TD>&nbsp;</TD>
</TR>

<TR valign="bottom">
        <TD valign="top"><FONT size="2">/s/ William T. Comer, Ph.D.</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">June&nbsp;26, 2001</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top"><FONT size="2"><HR size="1" noshade></FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">WILLIAM T. COMER, PH.D</FONT></TD>
</TR>
<TR>
<TD>&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">&nbsp;
        <HR align="center" size="1" noshade>
MICHAEL G. GREY</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">Director</FONT></TD>
        <TD></TD>
        <TD  align="left" valign="top"><FONT size="2">June&nbsp;26, 2001</FONT></TD>
</TR>
<TR>
<TD>&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD valign="top" align="center"><FONT size="2">&nbsp;
        <HR align="center" size="1" noshade>
JOHN P. MCKEARN, PH.D</FONT></TD>
        <TD></TD>
        <TD align="left" valign="top"><FONT size="2">Director</FONT></TD>
        <TD></TD>
        <TD align="left" valign="top"><FONT size="2">June&nbsp;26, 2001</FONT></TD>
</TR>
</TABLE>
</CENTER>


<DIV>&nbsp;</DIV>
<P align="center"><FONT size="2">6</FONT>
<DIV>&nbsp;</DIV>


<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left"><A HREF="#toc">Table of Contents</A></H5><P>


<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="006"></A></DIV>


<P align="center"><FONT size="2"><B>EXHIBIT INDEX</B></FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%" align="center">
<TR valign="bottom">
        <TD width="6%">&nbsp;</TD>
        <TD width="3%">&nbsp;</TD>
        <TD width="91%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"><B>Exhibit</B></FONT></TD>
        <TD></TD>
        <TD></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="2"><B>Number</B></FONT></TD>
        <TD></TD>
        <TD nowrap align="center"><FONT size="2"><B>Description</B></FONT></TD>
</TR>

<TR valign="bottom">
        <TD valign="top" align="right"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">5.1</FONT></DIV></TD>
        <TD></TD>
        <TD  align="left" valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
Opinion of Cooley Godward LLP.</FONT></DIV></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top" align="right"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">23.1</FONT></DIV></TD>
        <TD></TD>
        <TD  align="left" valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
Consent of Ernst &#38; Young LLP.</FONT></DIV></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top" align="right"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">23.2</FONT></DIV></TD>
        <TD></TD>
        <TD  align="left" valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
Consent of Cooley Godward LLP is contained in Exhibit&nbsp;5.1 to this Registration Statement.</FONT></DIV></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top" align="right"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">24.1</FONT></DIV></TD>
        <TD></TD>
        <TD  align="left" valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
Power of Attorney is contained on the signature pages.</FONT></DIV></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top" align="right"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">99.1</FONT></DIV></TD>
        <TD></TD>
        <TD  align="left" valign="top"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">
Epimmune Inc. 2001 Employee Stock Purchase Plan.</FONT></DIV></TD>
</TR>
</TABLE>
</CENTER>

<DIV>&nbsp;</DIV>
<P align="center"><FONT size="2">7</FONT>
<DIV>&nbsp;</DIV>

</BODY>
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s-8
Table of Contents
As filed with the Securities and
Exchange Commission on June 27, 2001
Registration No. 333-_________
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Epimmune Inc.
(Exact name of registrant as specified in its charter)
Delaware
(State of Incorporation)
33-0245076
(I.R.S. Employer Identification No.)
5820 Nancy Ridge Drive
San Diego, CA 92121
(858) 860-2500
(Address of principal executive offices)
2001 Employee Stock Purchase Plan
(Full title of the plans)
Emile Loria, M.D.
President and Chief Executive Officer
Epimmune Inc.
5820 Nancy Ridge Drive
San Diego, CA 92121
(858) 860-2500
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
L. Kay Chandler, Esq.
COOLEY GODWARD LLP
4635 Executive Drive, Suite 1100
San Diego, CA 92121
(858) 550-6000
CALCULATION OF REGISTRATION FEE
Proposed Maximum
Proposed Maximum
Title of Securities
Offering
Aggregate
Amount of
to be Registered
Amount to be Registered
Price per Share (1)
Offering Price (1)
Registration Fee
Common Stock, par value
$0.01 per share
300,000 shares
$
3.297
$
989,062.50
$
248
(1)
Estimated solely for the purpose of calculating the amount of the
registration fee pursuant to Rule 457(h)(1) of the Securities Act of 1933,
as amended, (the "Securities Act"). The price per share and aggregate
offering price are based upon the average of the high and low prices of
Registrant's Common Stock on June 21, 2001, as reported on the Nasdaq
National Market.
TABLE OF CONTENTS
INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
INDEMNIFICATION OF DIRECTORS AND OFFICERS
EXHIBITS
UNDERTAKINGS
SIGNATURES
POWER OF ATTORNEY
EXHIBIT INDEX
EXHIBIT 5.1
EXHIBIT 23.1
Exhibit 99.1
Table of Contents
INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
We are a reporting company and file annual, quarterly and current reports,
proxy statements and other information with the SEC. You may read and copy
these reports, proxy statements and other information at the SEC's public
reference rooms in Washington, D.C., New York, NY and Chicago, IL. You can
request copies of these documents by writing to the SEC and paying a fee for
the copying cost. Please call the SEC at 1-800-SEC-0330 for more information
about the operation of the public reference rooms. Our SEC filings are also
available at the SEC's Web site at "http://www.sec.gov".
The SEC allows us to incorporate by reference information that we file
with them, which means that we can disclose important information to you by
referring you to those documents. The information incorporated by reference is
an important part of this prospectus, and information that we file later with
the SEC will automatically update and supersede this information. We
incorporate by reference the documents listed below:
•
Annual Report on Form 10-K for the year ended December 31, 2000;
•
Proxy Statement on Schedule 14A filed April 27, 2001;
•
Quarterly Report on Form 10-Q for the quarter ended March 31, 2001; and
•
Our registration statement on Form 8-A, as amended, which
includes a description of our common stock.
All reports and other documents that we subsequently file prior to the
filing of a post-effective amendment, which indicates that all securities
offered have been sold or which deregisters all securities then remaining
unsold, shall be deemed to be incorporated by reference herein and to be a part
hereof from the date of the filing of such reports and documents.
We hereby undertake to provide without charge to each person to whom a
copy of this prospectus is delivered, upon written or oral request of any such
person, a copy of any and all of the information that has been or may be
incorporated by reference in this prospectus, other than exhibits to such
documents. Requests for such copies should be directed to the attention of our
Investor Relations department, at
Epimmune Inc.
5820 Nancy Ridge Drive
San Diego, CA 92121
(858)860-2500
INDEMNIFICATION OF DIRECTORS AND OFFICERS
Our Certificate of Incorporation and Bylaws include provisions to (i)
eliminate the personal liability of our directors for monetary damages
resulting from breaches of their fiduciary duty to the extent permitted by
Section 102(b)(7) of the Delaware General Corporation Law ("DGCL") and (ii)
require us to indemnify our directors and officers to the fullest extent
permitted by applicable law, including circumstances in which indemnification
is otherwise discretionary. Pursuant to Section 145 of the DGCL, a corporation
generally has the power to indemnify its present and former directors,
officers, employees and agents against expenses incurred by them in connection
with any suit to which they are or are threatened to be made, a party by reason
of their serving in such positions so long as they acted in good faith and in a
manner they reasonably believed to be in or not opposed to, the best interests
of the corporation and with respect to any criminal action, they had no
reasonable cause to believe their conduct was unlawful. We believe that these
provisions are necessary to attract and retain qualified persons as directors
and officers. These provisions do not eliminate the directors' or officers'
duty of care, and, in appropriate circumstances, equitable remedies such as
injunctive or other forms of non-monetary relief will remain available under
the DGCL. In addition, each director will continue to be subject to liability
pursuant to Section 174 of the DGCL, for breach of the director's duty of
loyalty to us, for acts or omissions not in good faith or involving
2
Table of Contents
intentional misconduct, for knowing violations of law, for acts or
omissions that the director believes to be contrary to our best interests or
our stockholders, for any transaction from which the director derived an
improper personal benefit, for acts or omissions involving a reckless disregard
for the director's duty to us or our stockholders when the director was aware
or should have been aware of a risk of serious injury to us or our
stockholders, for acts or omission that constitute an unexcused pattern of
inattention that amounts to an abdication of the director's duty to us or our
stockholders, for improper transactions between the director and us and for
improper loans to directors and officers. The provision also does not affect a
director's responsibilities under any other law, such as the federal securities
law or state or federal environmental laws.
We have entered into indemnity agreements with each of our directors and
executive officers that require us to indemnify such persons against expenses,
judgments, fines, settlements and other amounts incurred (including expenses of
a derivative action) in connection with any proceeding, whether actual or
threatened, to which any such person may be made a party by reason of the fact
that such person is or was one of our directors or executive officers or a
director or executive officer of any of our affiliated enterprises, provided
such person acted in good faith and in a manner such person reasonably believed
to be in or not opposed to the best interests of us and, with respect to any
criminal proceeding, had no reasonable cause to believe his conduct was
unlawful. The indemnification agreements also set forth certain procedures that
will apply in the event of a claim for indemnification thereunder.
At present, there is no pending litigation or proceeding involving our
directors or officers as to which indemnification is being sought nor are we
aware of any threatened litigation that may result in claims for
indemnification by any officer or director.
3
Table of Contents
EXHIBITS
Exhibit
Number
5.1
Opinion of Cooley Godward LLP.
23.1
Consent of Ernst & Young LLP.
23.2
Consent of Cooley Godward LLP is contained in Exhibit 5.1 to this Registration Statement.
24.1
Power of Attorney is contained on the signature pages.
99.1
Epimmune Inc. 2001 Employee Stock Purchase Plan.
UNDERTAKINGS
1.
The undersigned registrant hereby undertakes:
(a)
To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:
(i)
To include any prospectus required by section 10(a)(3) of the
Securities Act;
(ii)
To reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that
which was registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule 424(b) (§ 230.424(b) of this
chapter) if, in the aggregate, the changes in volume and price represent no
more than a 20% change in the maximum aggregate offering price set forth in the
"Calculation of Registration Fee" table in the effective registration
statement.
(iii)
To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement;
Provided, however,
that paragraphs (a)(i) and (a)(ii) do not apply if the
information required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed by the issuer pursuant to
section 13 or section 15(d) of the Exchange Act that are incorporated by
reference herein.
(b)
That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered herein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
(c)
To remove from registration by means of a post-effective amendment any
of the securities being registered, which remain, unsold at the termination of
the offering.
2.
The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of
the Exchange Act (and, where applicable, each filing of an employee
benefit plan's annual report pursuant to section 15(d) of the Exchange
Act) that is incorporated by reference in the Registration Statement shall
be
4
Table of Contents
deemed to be a new registration statement relating to the securities
offered herein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.
3.
Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as
expressed in the Securities Act and is, therefore, unenforceable. In the
event that a claim for indemnification against such liabilities (other
than the payment by the registrant of expenses incurred or paid by a
director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities
being registered, the registrant will, unless in the opinion of its
counsel the matter has been settled by controlling precedent, submit to a
court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the
Securities Act and will be governed by the final adjudication of such
issue.
5
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of San Diego, State of California, on June 26,
2001.
Epimmune Inc.
By:
/s/ Emile Loria, M.D.
Emile Loria, M.D.
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS
, that each person whose signature
appears below constitutes and appoints Emile Loria, M.D. and Robert J. De
Vaere, and each or any one of them, his true and lawful attorney-in-fact and
agent, with full power of substitution and resubstitution, for him and in his
name, place and stead, in any and all capacities, to sign any and all
amendments (including post-effective amendments) to this Registration
Statement, and to file the same, with all exhibits thereto, and other documents
in connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in connection therewith, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that said attorneys-in-fact and agents, or any of them, or their or his
substitutes or substitute, may lawfully do or cause to be done by virtue
hereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
Signature
Title
Date
/s/ Emile Loria, M.D.
President, Chief Executive Officer and Director
June 26, 2001
EMILE LORIA, M.D.
(Principal
Executive Officer)
/s/ Robert J. De Vaere
Vice President, Finance and Chief Financial Officer
June 26, 2001
ROBERT J. DE VAERE
(Principal Financial and Accounting
Officer)
/s/ Howard E. Greene, Jr.
Director
June 26, 2001
HOWARD E. GREENE, JR
/s/ William T. Comer, Ph.D.
Director
June 26, 2001
WILLIAM T. COMER, PH.D
MICHAEL G. GREY
Director
June 26, 2001
JOHN P. MCKEARN, PH.D
Director
June 26, 2001
6
Table of Contents
EXHIBIT INDEX
Exhibit
Number
Description
5.1
Opinion of Cooley Godward LLP.
23.1
Consent of Ernst & Young LLP.
23.2
Consent of Cooley Godward LLP is contained in Exhibit 5.1 to this Registration Statement.
24.1
Power of Attorney is contained on the signature pages.
99.1
Epimmune Inc. 2001 Employee Stock Purchase Plan.
7