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<center><FONT size="2">As filed with the Securities and Exchange Commission on September&nbsp;7, 2001&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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<P align="center"><FONT size="2"><B>SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</B></FONT>

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  <br>
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  <FONT size="2"><B>FORM S-8</B></FONT>
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<P align="center"><FONT size="2"><B>REGISTRATION STATEMENT<BR>
UNDER THE SECURITIES ACT OF 1933</B></FONT>

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    <br>
    <hr size="1" width="200">
    <FONT size="2"><B>LA JOLLA PHARMACEUTICAL COMPANY</B><BR>
    (Exact name of Registrant as Specified in Its Charter)</FONT>
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        <TD valign="top">
        <div align="center"><FONT size="2"><B>Delaware</B></FONT></div>
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        <TD><FONT size="2">&nbsp;</FONT></TD>
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        <div align="center"><FONT size="2"> <B>33-0361285</B></FONT></div>
      </TD>
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<TR><TD><TR><TD><TR><TD><TR><TD>
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        <TD valign="top">
        <div align="center"><FONT size="2">(State or Other Jurisdiction of</FONT></div>
      </TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top">
        <div align="center"><FONT size="2"> (I.R.S. Employer</FONT></div>
      </TD>
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<TR><TD><TR><TD><TR><TD><TR><TD>
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        <TD valign="top">
        <div align="center"><FONT size="2">Incorporation or Organization)</FONT></div>
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        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top">
        <div align="center"><FONT size="2"> Identification No.)</FONT></div>
      </TD>
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  <hr size="1" width="200">
  <FONT size="2"><B>6455 Nancy Ridge Drive<BR>
  San Diego, California 92121<BR>
  (858)&nbsp;452-6600</B><BR>
  (Address, including Zip Code, and Telephone Number,<BR>
  including Area Code, of Registrant&#146;s Principal Executive Offices)</FONT>
  <center>
    <br>
    <hr size="1" width="200">
    <FONT size="2"><B>LA JOLLA PHARMACEUTICAL COMPANY 1994 STOCK INCENTIVE PLAN<BR>
    LA JOLLA PHARMACEUTICAL COMPANY 1995 EMPLOYEE STOCK<BR>
    PURCHASE PLAN</B><BR>
    (Full Title of Plan)</FONT>
  </center>
  <center>
    <br>
    <hr size="1" width="200">
    <FONT size="2"><B>Steven B. Engle<BR>
    LA JOLLA PHARMACEUTICAL COMPANY<BR>
    6455 Nancy Ridge Drive<BR>
    San Diego, California 92121<BR>
    (858)&nbsp;452-6600</B><BR>
    (Name, address, including zip code, and telephone number, including area code,
    of agent for service)</FONT>
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  <center>
    <br>
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    <FONT size="2"><B>Copies to:</B></FONT>
  </center>
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<P align="center"><FONT size="2"><B>Leonard J. McGill<BR>
GIBSON, DUNN &#038; CRUTCHER LLP<BR>
4 Park Plaza, Suite&nbsp;1700<BR>
Irvine, California 92614-8557<BR>
(949)&nbsp;451-3800</B><BR>
(Name, address, including zip code, and telephone number, including area code, of agent for service)</FONT>

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    <FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B></FONT>
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      <TD width="11%">&nbsp;</TD>
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      <TD width="2%">&nbsp;</TD>
      <TD width="1%">&nbsp;</TD>
      <TD width="3%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
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      <TD width="7%">&nbsp;</TD>
      <TD width="5%">&nbsp;</TD>
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      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Maximum</B></FONT></TD>
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      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Maximum</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD><FONT size="1">&nbsp;</FONT></TD>
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      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
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      <TD nowrap align="center"><FONT size="1"><B>Title of Securities</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>to be</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Price Per</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration</B></FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD nowrap align="center"><FONT size="1"><B>to be Registered</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registered(1)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Share(2)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Price(2)</B></FONT></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center" colspan="3"><FONT size="1"><B>Fee</B></FONT></TD>
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        <DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common
          Stock, par value $0.01 per share</FONT></DIV>
      </TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD nowrap align="right"><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">2,000,000 </FONT></TD>
      <TD nowrap><FONT size="2">(3)(4)</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">6.645</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">13,290,000</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="right"><FONT size="2">$</FONT></TD>
      <TD align="right"><FONT size="2">3,322.50</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
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      <TD colspan="17"> <FONT size="2">&nbsp;</FONT><FONT size="2">&nbsp;</FONT><FONT size="2">&nbsp;</FONT>
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        <FONT size="2">&nbsp;</FONT></TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Each share of Common Stock includes a right to purchase one
one-thousandth of a share of Series&nbsp;A Junior Participating Preferred Stock
pursuant to the Rights Agreement between the Registrant and American Stock
Transfer &#038; Trust Company, as Rights Agent, as amended. Pursuant to Rule
416(a), this Registration Statement also covers shares</FONT></TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">of Common Stock issued pursuant to antidilution provisions set forth in
the La Jolla Pharmaceutical Company 1994 Stock Incentive Plan and 1995
Employee Stock Purchase Plan.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="top">
      <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Estimated solely for the purpose of calculating the registration fee
pursuant to Rules&nbsp;457(c) and 457(h) and based on the average of the high
and the low price of the Common Stock of the Registrant as reported on
August&nbsp;31, 2001 on the Nasdaq National Market System.</FONT></TD>
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<TR><TD><TR><TD><TR><TD><TR><TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Represents a 1,700,000 share increase in the number of shares authorized
for issuance under the La Jolla Pharmaceutical Company 1994 Stock
Incentive Plan. 5,200,000 shares of our common stock are issuable under
the 1994 Stock Incentive Plan. In addition to the shares of common stock
registered hereby, 750,000 shares of our common stock issuable under the
1994 Stock Incentive Plan were previously registered under the
Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;33-82664) as filed
with the Securities and Exchange Commission on August&nbsp;11, 1994; 500,000
shares of our common stock issuable under the 1994 Stock Incentive Plan
were previously registered under the Registration Statement on Form&nbsp;S-8
(Registration No.&nbsp;333-14285) as filed with the Securities and Exchange
Commission on October&nbsp;17, 1996; 500,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;333-29575)
as filed with the Securities and Exchange Commission on June&nbsp;19, 1997;
750,000 shares of our common stock issuable under the 1994 Stock Incentive
Plan were previously registered under the Registration Statement on Form
S-8 (Registration No.&nbsp;333-91593) as filed with the Securities and Exchange
Commission on November&nbsp;24, 1999; and 1,000,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;333-45080)
as filed with the Securities and Exchange Commission on September&nbsp;1, 2000.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(4)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Represents a 300,000 share increase in the number of shares authorized
for issuance under the La Jolla Pharmaceutical Company 1995 Employee Stock
Purchase Plan. 800,000 shares of our common stock are issuable under the
1995 Employee Stock Purchase Plan. In addition to the shares of common
stock registered hereby, 300,000 shares of our common stock issuable under
the 1995 Employee Stock Purchase Plan were previously registered under the
Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;33-94830) as filed
with the Securities and Exchange Commission on July&nbsp;21, 1995; and 200,000
shares of our common stock issuable under the 1995 Employee Stock Purchase
Plan were previously registered under the Registration Statement on Form
S-8 (Registration No.&nbsp;333-45080) as filed with the Securities and Exchange
Commission on September&nbsp;1, 2000.</FONT></TD>
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<P align="center"><FONT size="2">2
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<A name="toc"><DIV align="CENTER"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD colspan="9"><A HREF="#000">PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">Item&nbsp;1. Plan Information.*</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;2. Registrant Information and Employee Plan Annual Information.*</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;6. Indemnification of Officers and Directors</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;8. Exhibits.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;9. Undertakings.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#007">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#008">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="a75600orex5.txt">EXHIBIT 5</A></TD></TR>
<TR><TD colspan="9"><A HREF="a75600orex23-1.txt">EXHIBIT 23.1</A></TD></TR>
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<P align="center"><FONT size="2"><B>INTRODUCTION</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We are filing this Registration Statement on Form&nbsp;S-8 to register an
additional 1,700,000 shares of our common stock that we may issue under our
1994 Stock Incentive Plan and an additional 300,000 shares of our common stock
that we may issue under our 1995 Employee Stock Purchase Plan. We have
included in this Registration Statement only those items required by General
Instruction E to Form&nbsp;S-8.
</FONT>
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<DIV align="left"><A NAME="000"></A></DIV>
<P align="center"><FONT size="2"><B>PART I<br>
  </B></FONT><FONT size="2"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B></FONT>
<!-- link2 "Item&nbsp;1. Plan Information.*" -->
<DIV align="left"><A NAME="001"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;1. Plan Information.*</B></FONT>

<!-- link2 "Item&nbsp;2. Registrant Information and Employee Plan Annual Information.*" -->
<DIV align="left"><A NAME="002"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;2. Registrant Information and Employee Plan Annual Information.*</B></FONT>

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    <TD width="1%" align="left" nowrap><font size="2"><b>*</b></font></TD>
        <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
        <TD width="98%"><FONT size="2">Information required by Part I of Form&nbsp;S-8 to be contained in the Section
10(a) prospectus is omitted from this registration statement in accordance
with Rule&nbsp;428 under the Securities Act of 1933, as amended (the
&#147;Securities Act&#148;), and the Note to Part I of Form&nbsp;S-8.</FONT></TD>
</TR>
</TABLE>
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<DIV align="left"><A NAME="003"></A></DIV>
<P align="center"><FONT size="2"><B>PART II<br>
  </B></FONT><FONT size="2"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with General Instruction E to Form&nbsp;S-8, the contents of our
Registration Statement on Form&nbsp;S-8 (Registration No.&nbsp;33-82664) previously filed
by us with the Securities and Exchange Commission on August&nbsp;11, 1994 relating
to the 1994 Stock Incentive Plan, and the contents of our Registration
Statement on Form&nbsp;S-8 (Registration No.&nbsp;33-94830) previously filed by us with
the Securities and Exchange Commission on July&nbsp;21, 1995 relating to the 1995
Employee Stock Purchase Plan, are incorporated herein by reference and made a
part hereof.
</FONT>
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<DIV align="left"><A NAME="004"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;6. Indemnification of Officers and Directors</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(a) of the General Corporation Law of the State of Delaware
(the &#147;DGCL&#148;) provides that a Delaware corporation may indemnify any person who
was or is a party or is threatened to be made a party to any threatened,
pending or completed action, suit or proceeding, whether civil, criminal,
administrative or investigative, other than an action by or in the right of the
corporation, by reason of the fact that such person is or was a director,
officer, employee or agent of the corporation or is or was serving at the
request of the corporation as a director, officer, employee or agent of another
corporation or enterprise, against expenses, judgments, fines and amounts paid
in settlement actually and reasonably incurred by such person in connection
with such action, suit or proceeding if he or she acted in good faith and in a
manner he or she reasonably believed to be in or not opposed to the best
interests of the corporation, and, with respect to any criminal action or
proceeding, had no cause to believe his or her conduct was unlawful.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(b) of the DGCL provides that a Delaware corporation may
indemnify any person who was or is a party or is threatened to be made a party
to any threatened, pending or completed action or suit by or in the right of
corporation to procure a judgment in its favor by reason of the fact that such
person acted in any of the capacities set forth above, against expenses
actually and reasonably incurred by such person in connection with the defense
or settlement of such action or suit if he or she acted under similar standards
to those set forth above, except that no indemnification may be made in respect
to any claim, issue or matter as to which such person shall have been adjudged
to be liable to the corporation unless and only to the extent that the court in
which such action or suit was brought shall determine that despite the
adjudication of liability, but in view of all the circumstances of the case,
such person is fairly and reasonably entitled to be indemnified for such
expenses which the court shall deem proper.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the DGCL further provides that to the extent a director or
officer of a corporation has been successful in the defense of any action, suit
or proceeding referred to in subsection (a)&nbsp;and (b)&nbsp;of Section&nbsp;145 or in the
defense of any claim, issue or matter therein, he or she shall be indemnified
against expenses actually and reasonably incurred by him or her in connection
therewith; that indemnification provided for by Section&nbsp;145 shall not be deemed
exclusive of any other rights to which the indemnified party may be entitled;
and that the corporation
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<P><FONT size="2">may purchase and maintain insurance on behalf of a director or officer of
the corporation against any liability asserted against such officer or director
and incurred by him or her in any such capacity or arising out of his or her
status as such, whether or not the corporation would have the power to
indemnify him or her against such liabilities under Section&nbsp;145.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As permitted by Section&nbsp;102(b)(7) of the DGCL our certificate of
incorporation provides that a director shall not be liable to us or our
stockholders for monetary damages for breach of fiduciary duty as a director.
However, such provision does not eliminate or limit the liability of a director
for acts or omissions not in good faith or for breaching his or her duty of
loyalty, engaging in intentional misconduct or knowingly violating the law,
paying a dividend or approving a stock repurchase which was illegal, or
obtaining an improper personal benefit. A provision of this type has no effect
on the availability of equitable remedies, such as injunction or rescission,
for breach of fiduciary duty.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Our bylaws require that directors and officers be indemnified to the
maximum extent permitted by Delaware law.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We have entered into indemnity agreements with each of our directors and
executive officers. These indemnity agreements require that we pay on behalf
of each director and officer party thereto any amount that he or she is or
becomes legally obligated to pay because of any claim or claims made against
him or her because of any act or omission or neglect or breach of duty,
including any actual or alleged error or misstatement or misleading statement,
which he or she commits or suffers while acting in his or her capacity as our
director and/or officer and solely because of his or her being a director
and/or officer. Under the General Corporation Law, absent such an indemnity
agreement, indemnification of a director or officer is discretionary rather
than mandatory (except in the case of a proceeding in which a director or
officer is successful on the merits). Consistent with our Bylaw provision on
the subject, the indemnity agreements require us to make prompt payment of
defense and investigation costs and expenses at the request of the director or
officer in advance of indemnification, provided that the recipient undertakes
to repay the amounts if it is ultimately determined that he or she is not
entitled to indemnification for such expenses and provided further that such
advance shall not be made if it is determined that the director or officer
acted in bad faith or deliberately breached his or her duty to us or our
stockholders and, as a result, it is more likely than not that it will
ultimately be determined that he or she is not entitled to indemnification
under the terms of the indemnity agreement. The indemnity agreements make the
advance of litigation expenses mandatory absent a special determination to the
contrary, whereas under the General Corporation Law absent such an indemnity
agreement, such advance would be discretionary. Under the indemnity agreement,
the director or officer is permitted to petition the court to seek recovery of
amounts due under the indemnity agreement and to recover the expenses of
seeking such recovery if he or she is successful. Without the indemnity
agreement, we would not be required to pay or reimburse the director or officer
for his or her expenses in seeking indemnification recovery against us. By the
terms of the indemnity agreement, its benefits are not available if the
director or officer has other indemnification or insurance coverage for the
subject claim or, with respect to the matters giving rise to the claim, (i)
received a personal benefit, (ii)&nbsp;violated Section&nbsp;16(b) of the Securities
Exchange Act of 1934 or analogous provisions of law, or (iii)&nbsp;committed certain
acts of dishonesty. Absent the indemnity agreement, indemnification that might
be made available to directors and officers could be changed by amendments to
our Certificate of Incorporation or Bylaws.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We have a policy of directors and officers liability insurance that
insures us and our directors and officers against damages, settlements, and
defense costs under certain circumstances.
</FONT>
<!-- link2 "Item&nbsp;8. Exhibits." -->
<DIV align="left"><A NAME="005"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits.</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to General Instruction E, only those opinions and consents
required by Item&nbsp;8 are provided. They are as follows:
</FONT>
<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="8%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="79%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
</TR>
<TR valign="bottom">
          <TD nowrap align="center"><font size="2">Exhibit No.</font></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center">
        <div align="left"><font size="2">Description</font></div>
      </TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top">
        <div align="center"><FONT size="2">5</FONT></div>
      </TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Opinion of Gibson, Dunn &#038; Crutcher LLP.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top">
        <div align="center"><FONT size="2">23.1</FONT></div>
      </TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, independent auditors.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top">
        <div align="center"><FONT size="2">23.3</FONT></div>
      </TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Gibson, Dunn &#038; Crutcher LLP (contained in Exhibit&nbsp;5 hereto)</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top">
        <div align="center"><FONT size="2">24</FONT></div>
      </TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Power of Attorney (contained on signature page hereto)</FONT></TD>
</TR>
</TABLE>
  <br>
</CENTER>
<P align="center"><FONT size="2">4
</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link2 "Item&nbsp;9. Undertakings." -->
<DIV align="left"><A NAME="006"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;9. Undertakings.</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp; The undersigned registrant hereby undertakes:
</FONT>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="1%" nowrap>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
        <TD width="99%"></TD>
</TR>
<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To file, during any period in which offers or sales are being
made, a post-effective amendment to this Registration Statement:</FONT></TD>
</TR>
</TABLE>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="1%" nowrap>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
        <TD width="99%"></TD>
</TR>
<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;To include any prospectus required by Section
10(a)(3) of the Securities Act;</FONT></TD>
</TR>
</TABLE>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="1%" nowrap>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
        <TD width="99%"></TD>
</TR>
<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;To reflect in the prospectus any facts or events
arising after the effective date of the Registration
Statement (or the most recent post-effective amendment
thereof) which, individually or in the aggregate,
represent a fundamental change in the information set
forth in the Registration Statement;</FONT></TD>
</TR>
</TABLE>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="1%" nowrap>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
        <TD width="99%"></TD>
</TR>
<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;To include any material information with respect
to the plan of distribution not previously disclosed
in the Registration Statement or any material change
to such information in the Registration Statement;</FONT></TD>
</TR>
</TABLE>
<P><FONT size="2"><I>provided, however, </I>that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply
if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or
furnished to the Commission by the registrant pursuant to Section&nbsp;13 or
Section&nbsp;15(d) of the Exchange Act that are incorporated by reference in
the Registration Statement.
</FONT>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="1%" nowrap>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
        <TD width="99%"></TD>
</TR>
<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;That, for the purpose of determining any liability under the
Securities Act each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be
the initial <I>bona fide </I>offering thereof.</FONT></TD>
</TR>
</TABLE>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR>
        <TD width="1%" nowrap>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
        <TD width="99%"></TD>
</TR>
<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at
the termination of the offering.</FONT></TD>
</TR>
</TABLE>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp; The undersigned registrant hereby undertakes that, for purposes
of determining any liability under the Securities Act, each filing of
the registrant&#146;s annual report pursuant to Section&nbsp;13(a) or 15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit
plan&#146;s annual report pursuant to Section&nbsp;15(d) of the Securities
Exchange Act) that is incorporated by reference in this Registration
Statement shall be deemed to be a new registration statement relating to
the securities offered therein, and the offering of such securities at
that time shall be deemed to be the initial <I>bona fide </I>offering thereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp; Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or
otherwise, the registrant has been advised that in the opinion of the
Commission such indemnification is against public policy as expressed in
the Securities Act and is, therefore, unenforceable. In the event that
a claim for indemnification against such liabilities (other than the
payment by the registrant of expenses incurred or paid by a director,
officer or controlling person of the registrant in the successful
defense of any action, suit or proceeding) is asserted by such director,
officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court
of appropriate jurisdiction the question of whether such indemnification
by it is against public policy as expressed in the Act and will be
governed by a final adjudication of such issue.
</FONT>
<P align="center"><FONT size="2">5
</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="007"></A></DIV>
<P align="center"><FONT size="2"><B>SIGNATURES</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form&nbsp;S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California, on September&nbsp;5,
2001.
</FONT>
<CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
    <TR valign="bottom">
      <TD width="50%">&nbsp;</TD>
      <TD width="7%">&nbsp;</TD>
      <TD width="43%">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD colspan="2"><FONT size="2">&nbsp;</FONT><FONT size="2"><B>LA JOLLA PHARMACEUTICAL
        COMPANY</B></FONT></TD>
    </TR>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">By:&nbsp;</FONT></TD>
      <TD align="left" rowspan="2"><FONT size="2"> /s/ Steven B. Engle</FONT>
        <HR size="1" noshade>
      </TD>
    </TR>
    <TR>
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
      <TD valign="top"><FONT size="2">Name: Title:&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Steven B. Engle <br>
        Chairman and Chief Executive Officer</FONT></TD>
    </TR>
  </TABLE>
</CENTER>
<P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Steven
B. Engle and Gail A. Sloan his or her true and lawful attorneys-in-fact and
agents, each acting alone, with full powers of substitution and resubstitution,
for him or her and in his or her name, place and stead, in any and all
capacities, to sign any and all amendments (including post-effective
amendments) to this Registration Statement and to file the same, with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and
agents, each acting alone, full power and authority to do and perform each and
every act and thing requisite and necessary to be done in and about the
premises, as full to all intents and purposes as he or she might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and
agents, each acting alone, or his substitute or substitutes, may lawfully do or
cause to be done by virtue hereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities indicated below and on the date indicated.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;September&nbsp;5, 2001
</FONT>
<CENTER>
  <TABLE cellspacing="0" border="0" cellpadding="0" width="95%">
    <TR valign="bottom">
      <TD width="36%">&nbsp;</TD>
      <TD width="10%">&nbsp;</TD>
      <TD width="54%">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD nowrap align="center"><font size="2">NAME AND SIGNATURE</font></TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center"><font size="2">TITLE</font></TD>
    </TR>
    <TR valign="bottom">
      <TD nowrap align="center">
        <HR size="1" noshade>
      </TD>
      <TD><FONT size="1">&nbsp;</FONT></TD>
      <TD nowrap align="center">
        <HR size="1" noshade>
      </TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Steven B. Engle
        <HR size="1" noshade>
        Steven B. Engle</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Chairman of the Board, Chief
        Executive Officer, President and Director (Principal Executive Officer)</FONT></TD>
    </TR>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Gail A. Sloan
        <HR size="1" noshade>
        Gail A. Sloan</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Secretary and Controller (Principal
        Financial and Accounting Officer)</FONT></TD>
    </TR>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;
        <HR size="1" noshade>
        Thomas H. Adams, Ph.D.</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Director</FONT></TD>
    </TR>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ William E. Engbers
        <HR size="1" noshade>
        William E. Engbers</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Director</FONT></TD>
    </TR>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Robert A. Fildes
        <HR size="1" noshade>
        Robert A. Fildes, Ph.D.</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Director</FONT></TD>
    </TR>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ Stephen M. Martin
        <HR size="1" noshade>
        Stephen M. Martin</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Director</FONT></TD>
    </TR>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">/s/ W. Leigh Thompson
        <HR size="1" noshade>
        W. Leigh Thompson, M.D., Ph.D.</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Director</FONT></TD>
    </TR>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR>
      <TD>
    <TR valign="bottom">
      <TD valign="top">&nbsp;</TD>
      <TD>&nbsp;</TD>
      <TD align="left" valign="top">&nbsp;</TD>
    </TR>
    <TR valign="bottom">
      <TD valign="top"><FONT size="2">&nbsp;
        <HR size="1" noshade>
        William R. Ringo</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="left" valign="top"><FONT size="2"> Director</FONT></TD>
    </TR>
  </TABLE>
  <br>
</CENTER>
<P align="center"><FONT size="2">6
</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="008"></A></DIV>
<P align="center"><FONT size="2"><B>EXHIBIT INDEX</B></FONT>

<CENTER>
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<TR valign="bottom">
        <TD width="8%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
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        <TD width="5%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
</TR>
<TR valign="bottom">
          <TD nowrap align="center"><font size="2">Exhibit No.</font></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
          <TD nowrap align="center">
        <div align="left"><font size="2">Description</font></div>
      </TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD valign="top">
        <div align="center"><FONT size="2">5</FONT></div>
      </TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Opinion of Gibson, Dunn &#038; Crutcher LLP.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top">
        <div align="center"><FONT size="2">23.1</FONT></div>
      </TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, independent auditors.</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top">
        <div align="center"><FONT size="2">23.3</FONT></div>
      </TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Gibson, Dunn &#038; Crutcher LLP (contained in Exhibit&nbsp;5 hereto)</FONT></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>
<TR valign="bottom">
        <TD valign="top">
        <div align="center"><FONT size="2">24</FONT></div>
      </TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Power of Attorney (contained on signature page hereto)</FONT></TD>
</TR>
</TABLE>
</CENTER>

<P align="center">&nbsp;
</BODY>
</HTML>
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La Jolla Pharmaceutical Company
Table of Contents
As filed with the Securities and Exchange Commission on September 7, 2001    
  Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OF 1933
LA JOLLA PHARMACEUTICAL COMPANY
(Exact name of Registrant as Specified in Its Charter)
Delaware
33-0361285
(State or Other Jurisdiction of
(I.R.S. Employer
Incorporation or Organization)
Identification No.)
6455 Nancy Ridge Drive
San Diego, California 92121
(858) 452-6600
(Address, including Zip Code, and Telephone Number,
including Area Code, of Registrant's Principal Executive Offices)
LA JOLLA PHARMACEUTICAL COMPANY 1994 STOCK INCENTIVE PLAN
LA JOLLA PHARMACEUTICAL COMPANY 1995 EMPLOYEE STOCK
PURCHASE PLAN
(Full Title of Plan)
Steven B. Engle
LA JOLLA PHARMACEUTICAL COMPANY
6455 Nancy Ridge Drive
San Diego, California 92121
(858) 452-6600
(Name, address, including zip code, and telephone number, including area code,
    of agent for service)
Copies to:
Leonard J. McGill
GIBSON, DUNN & CRUTCHER LLP
4 Park Plaza, Suite 1700
Irvine, California 92614-8557
(949) 451-3800
(Name, address, including zip code, and telephone number, including area code, of agent for service)
CALCULATION OF REGISTRATION FEE
Proposed
Proposed
Maximum
Maximum
Amount
Offering
Aggregate
Amount of
Title of Securities
to be
Price Per
Offering
Registration
to be Registered
Registered(1)
Share(2)
Price(2)
Fee
Common
          Stock, par value $0.01 per share
2,000,000
(3)(4)
$
6.645
$
13,290,000
$
3,322.50
(1)
Each share of Common Stock includes a right to purchase one
one-thousandth of a share of Series A Junior Participating Preferred Stock
pursuant to the Rights Agreement between the Registrant and American Stock
Transfer & Trust Company, as Rights Agent, as amended. Pursuant to Rule
416(a), this Registration Statement also covers shares
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of Common Stock issued pursuant to antidilution provisions set forth in
the La Jolla Pharmaceutical Company 1994 Stock Incentive Plan and 1995
Employee Stock Purchase Plan.
(2)
Estimated solely for the purpose of calculating the registration fee
pursuant to Rules 457(c) and 457(h) and based on the average of the high
and the low price of the Common Stock of the Registrant as reported on
August 31, 2001 on the Nasdaq National Market System.
(3)
Represents a 1,700,000 share increase in the number of shares authorized
for issuance under the La Jolla Pharmaceutical Company 1994 Stock
Incentive Plan. 5,200,000 shares of our common stock are issuable under
the 1994 Stock Incentive Plan. In addition to the shares of common stock
registered hereby, 750,000 shares of our common stock issuable under the
1994 Stock Incentive Plan were previously registered under the
Registration Statement on Form S-8 (Registration No. 33-82664) as filed
with the Securities and Exchange Commission on August 11, 1994; 500,000
shares of our common stock issuable under the 1994 Stock Incentive Plan
were previously registered under the Registration Statement on Form S-8
(Registration No. 333-14285) as filed with the Securities and Exchange
Commission on October 17, 1996; 500,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form S-8 (Registration No. 333-29575)
as filed with the Securities and Exchange Commission on June 19, 1997;
750,000 shares of our common stock issuable under the 1994 Stock Incentive
Plan were previously registered under the Registration Statement on Form
S-8 (Registration No. 333-91593) as filed with the Securities and Exchange
Commission on November 24, 1999; and 1,000,000 shares of our common stock
issuable under the 1994 Stock Incentive Plan were previously registered
under the Registration Statement on Form S-8 (Registration No. 333-45080)
as filed with the Securities and Exchange Commission on September 1, 2000.
(4)
Represents a 300,000 share increase in the number of shares authorized
for issuance under the La Jolla Pharmaceutical Company 1995 Employee Stock
Purchase Plan. 800,000 shares of our common stock are issuable under the
1995 Employee Stock Purchase Plan. In addition to the shares of common
stock registered hereby, 300,000 shares of our common stock issuable under
the 1995 Employee Stock Purchase Plan were previously registered under the
Registration Statement on Form S-8 (Registration No. 33-94830) as filed
with the Securities and Exchange Commission on July 21, 1995; and 200,000
shares of our common stock issuable under the 1995 Employee Stock Purchase
Plan were previously registered under the Registration Statement on Form
S-8 (Registration No. 333-45080) as filed with the Securities and Exchange
Commission on September 1, 2000.
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PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Item 1. Plan Information.*
Item 2. Registrant Information and Employee Plan Annual Information.*
PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 6. Indemnification of Officers and Directors
Item 8. Exhibits.
Item 9. Undertakings.
SIGNATURES
EXHIBIT INDEX
EXHIBIT 5
EXHIBIT 23.1
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INTRODUCTION
We are filing this Registration Statement on Form S-8 to register an
additional 1,700,000 shares of our common stock that we may issue under our
1994 Stock Incentive Plan and an additional 300,000 shares of our common stock
that we may issue under our 1995 Employee Stock Purchase Plan. We have
included in this Registration Statement only those items required by General
Instruction E to Form S-8.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Item 1. Plan Information.*
Item 2. Registrant Information and Employee Plan Annual Information.*
*
Information required by Part I of Form S-8 to be contained in the Section
10(a) prospectus is omitted from this registration statement in accordance
with Rule 428 under the Securities Act of 1933, as amended (the
"Securities Act"), and the Note to Part I of Form S-8.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
In accordance with General Instruction E to Form S-8, the contents of our
Registration Statement on Form S-8 (Registration No. 33-82664) previously filed
by us with the Securities and Exchange Commission on August 11, 1994 relating
to the 1994 Stock Incentive Plan, and the contents of our Registration
Statement on Form S-8 (Registration No. 33-94830) previously filed by us with
the Securities and Exchange Commission on July 21, 1995 relating to the 1995
Employee Stock Purchase Plan, are incorporated herein by reference and made a
part hereof.
Item 6. Indemnification of Officers and Directors
Section 145(a) of the General Corporation Law of the State of Delaware
(the "DGCL") provides that a Delaware corporation may indemnify any person who
was or is a party or is threatened to be made a party to any threatened,
pending or completed action, suit or proceeding, whether civil, criminal,
administrative or investigative, other than an action by or in the right of the
corporation, by reason of the fact that such person is or was a director,
officer, employee or agent of the corporation or is or was serving at the
request of the corporation as a director, officer, employee or agent of another
corporation or enterprise, against expenses, judgments, fines and amounts paid
in settlement actually and reasonably incurred by such person in connection
with such action, suit or proceeding if he or she acted in good faith and in a
manner he or she reasonably believed to be in or not opposed to the best
interests of the corporation, and, with respect to any criminal action or
proceeding, had no cause to believe his or her conduct was unlawful.
Section 145(b) of the DGCL provides that a Delaware corporation may
indemnify any person who was or is a party or is threatened to be made a party
to any threatened, pending or completed action or suit by or in the right of
corporation to procure a judgment in its favor by reason of the fact that such
person acted in any of the capacities set forth above, against expenses
actually and reasonably incurred by such person in connection with the defense
or settlement of such action or suit if he or she acted under similar standards
to those set forth above, except that no indemnification may be made in respect
to any claim, issue or matter as to which such person shall have been adjudged
to be liable to the corporation unless and only to the extent that the court in
which such action or suit was brought shall determine that despite the
adjudication of liability, but in view of all the circumstances of the case,
such person is fairly and reasonably entitled to be indemnified for such
expenses which the court shall deem proper.
Section 145 of the DGCL further provides that to the extent a director or
officer of a corporation has been successful in the defense of any action, suit
or proceeding referred to in subsection (a) and (b) of Section 145 or in the
defense of any claim, issue or matter therein, he or she shall be indemnified
against expenses actually and reasonably incurred by him or her in connection
therewith; that indemnification provided for by Section 145 shall not be deemed
exclusive of any other rights to which the indemnified party may be entitled;
and that the corporation
3
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may purchase and maintain insurance on behalf of a director or officer of
the corporation against any liability asserted against such officer or director
and incurred by him or her in any such capacity or arising out of his or her
status as such, whether or not the corporation would have the power to
indemnify him or her against such liabilities under Section 145.
As permitted by Section 102(b)(7) of the DGCL our certificate of
incorporation provides that a director shall not be liable to us or our
stockholders for monetary damages for breach of fiduciary duty as a director.
However, such provision does not eliminate or limit the liability of a director
for acts or omissions not in good faith or for breaching his or her duty of
loyalty, engaging in intentional misconduct or knowingly violating the law,
paying a dividend or approving a stock repurchase which was illegal, or
obtaining an improper personal benefit. A provision of this type has no effect
on the availability of equitable remedies, such as injunction or rescission,
for breach of fiduciary duty.
Our bylaws require that directors and officers be indemnified to the
maximum extent permitted by Delaware law.
We have entered into indemnity agreements with each of our directors and
executive officers. These indemnity agreements require that we pay on behalf
of each director and officer party thereto any amount that he or she is or
becomes legally obligated to pay because of any claim or claims made against
him or her because of any act or omission or neglect or breach of duty,
including any actual or alleged error or misstatement or misleading statement,
which he or she commits or suffers while acting in his or her capacity as our
director and/or officer and solely because of his or her being a director
and/or officer. Under the General Corporation Law, absent such an indemnity
agreement, indemnification of a director or officer is discretionary rather
than mandatory (except in the case of a proceeding in which a director or
officer is successful on the merits). Consistent with our Bylaw provision on
the subject, the indemnity agreements require us to make prompt payment of
defense and investigation costs and expenses at the request of the director or
officer in advance of indemnification, provided that the recipient undertakes
to repay the amounts if it is ultimately determined that he or she is not
entitled to indemnification for such expenses and provided further that such
advance shall not be made if it is determined that the director or officer
acted in bad faith or deliberately breached his or her duty to us or our
stockholders and, as a result, it is more likely than not that it will
ultimately be determined that he or she is not entitled to indemnification
under the terms of the indemnity agreement. The indemnity agreements make the
advance of litigation expenses mandatory absent a special determination to the
contrary, whereas under the General Corporation Law absent such an indemnity
agreement, such advance would be discretionary. Under the indemnity agreement,
the director or officer is permitted to petition the court to seek recovery of
amounts due under the indemnity agreement and to recover the expenses of
seeking such recovery if he or she is successful. Without the indemnity
agreement, we would not be required to pay or reimburse the director or officer
for his or her expenses in seeking indemnification recovery against us. By the
terms of the indemnity agreement, its benefits are not available if the
director or officer has other indemnification or insurance coverage for the
subject claim or, with respect to the matters giving rise to the claim, (i)
received a personal benefit, (ii) violated Section 16(b) of the Securities
Exchange Act of 1934 or analogous provisions of law, or (iii) committed certain
acts of dishonesty. Absent the indemnity agreement, indemnification that might
be made available to directors and officers could be changed by amendments to
our Certificate of Incorporation or Bylaws.
We have a policy of directors and officers liability insurance that
insures us and our directors and officers against damages, settlements, and
defense costs under certain circumstances.
Item 8. Exhibits.
Pursuant to General Instruction E, only those opinions and consents
required by Item 8 are provided. They are as follows:
Exhibit No.
Description
5
Opinion of Gibson, Dunn & Crutcher LLP.
23.1
Consent of Ernst & Young LLP, independent auditors.
23.3
Consent of Gibson, Dunn & Crutcher LLP (contained in Exhibit 5 hereto)
24
Power of Attorney (contained on signature page hereto)
4
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Item 9. Undertakings.
(a)  The undersigned registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being
made, a post-effective amendment to this Registration Statement:
(i) To include any prospectus required by Section
10(a)(3) of the Securities Act;
(ii) To reflect in the prospectus any facts or events
arising after the effective date of the Registration
Statement (or the most recent post-effective amendment
thereof) which, individually or in the aggregate,
represent a fundamental change in the information set
forth in the Registration Statement;
(iii) To include any material information with respect
to the plan of distribution not previously disclosed
in the Registration Statement or any material change
to such information in the Registration Statement;
provided, however,
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply
if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or
furnished to the Commission by the registrant pursuant to Section 13 or
Section 15(d) of the Exchange Act that are incorporated by reference in
the Registration Statement.
(2) That, for the purpose of determining any liability under the
Securities Act each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be
the initial
bona fide
offering thereof.
(3) To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at
the termination of the offering.
(b)  The undersigned registrant hereby undertakes that, for purposes
of determining any liability under the Securities Act, each filing of
the registrant's annual report pursuant to Section 13(a) or 15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit
plan's annual report pursuant to Section 15(d) of the Securities
Exchange Act) that is incorporated by reference in this Registration
Statement shall be deemed to be a new registration statement relating to
the securities offered therein, and the offering of such securities at
that time shall be deemed to be the initial
bona fide
offering thereof.
(c)  Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or
otherwise, the registrant has been advised that in the opinion of the
Commission such indemnification is against public policy as expressed in
the Securities Act and is, therefore, unenforceable. In the event that
a claim for indemnification against such liabilities (other than the
payment by the registrant of expenses incurred or paid by a director,
officer or controlling person of the registrant in the successful
defense of any action, suit or proceeding) is asserted by such director,
officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court
of appropriate jurisdiction the question of whether such indemnification
by it is against public policy as expressed in the Act and will be
governed by a final adjudication of such issue.
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SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California, on September 5,
2001.
LA JOLLA PHARMACEUTICAL
        COMPANY
By:
/s/ Steven B. Engle
Name: Title:
Steven B. Engle
Chairman and Chief Executive Officer
POWER OF ATTORNEY
Each person whose signature appears below constitutes and appoints Steven
B. Engle and Gail A. Sloan his or her true and lawful attorneys-in-fact and
agents, each acting alone, with full powers of substitution and resubstitution,
for him or her and in his or her name, place and stead, in any and all
capacities, to sign any and all amendments (including post-effective
amendments) to this Registration Statement and to file the same, with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and
agents, each acting alone, full power and authority to do and perform each and
every act and thing requisite and necessary to be done in and about the
premises, as full to all intents and purposes as he or she might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and
agents, each acting alone, or his substitute or substitutes, may lawfully do or
cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities indicated below and on the date indicated.
September 5, 2001
NAME AND SIGNATURE
TITLE
/s/ Steven B. Engle
Steven B. Engle
Chairman of the Board, Chief
        Executive Officer, President and Director (Principal Executive Officer)
/s/ Gail A. Sloan
Gail A. Sloan
Secretary and Controller (Principal
        Financial and Accounting Officer)
Thomas H. Adams, Ph.D.
Director
/s/ William E. Engbers
William E. Engbers
Director
/s/ Robert A. Fildes
Robert A. Fildes, Ph.D.
Director
/s/ Stephen M. Martin
Stephen M. Martin
Director
/s/ W. Leigh Thompson
W. Leigh Thompson, M.D., Ph.D.
Director
William R. Ringo
Director
6
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EXHIBIT INDEX
Exhibit No.
Description
5
Opinion of Gibson, Dunn & Crutcher LLP.
23.1
Consent of Ernst & Young LLP, independent auditors.
23.3
Consent of Gibson, Dunn & Crutcher LLP (contained in Exhibit 5 hereto)
24
Power of Attorney (contained on signature page hereto)