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      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>As filed with the Securities and Exchange Commission on March&nbsp;25, 2025</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right"><B>Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></P>

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      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES<BR>SECURITIES AND EXCHANGE COMMISSION</B><BR><B>Washington, D.C. 20549</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-size: 14pt"><B>FORM S-8</B></FONT></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-size: 14pt"><B>NEONC TECHNOLOGIES
      HOLDINGS, INC.</B></FONT></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Exact name of registrant as specified in its charter)</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; width: 49%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Delaware</B></FONT></TD>
    <TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom; width: 2%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; width: 49%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>92-1954864</B></FONT></TD></TR>
  <TR STYLE="font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(State or other jurisdiction of</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">incorporation or organization)</FONT></P></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(I.R.S. Employer<BR> Identification No.)</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>2 Dole Drive</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Westlake Village, CA 91362</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Address of principal executive offices)</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(310) 663-7831</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Registrant&rsquo;s telephone number, including area code)</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>NeOnc Technologies Holdings, Inc. 2023 Equity
Incentive Plan</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Full title of the plan)</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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            <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"><B>Copy to:</B></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center">&nbsp;</TD></TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; width: 50%"><B>Dr. Thomas C. Chen</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center; width: 50%"><B>Thomas J. Poletti, Esq.</B></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"><B> Chief Executive Officer</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"><B>Veronica Lah, Esq.</B></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"><B>2 Dole Drive</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"><B>Manatt, Phelps &amp; Phillips, LLP</B></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"><B>Westlake Village, CA 91362</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"><B>695 Town Center Drive, 14</B><SUP><B>th</B></SUP><B> Floor</B></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"><B>(310) 663-7831</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"><B>Costa Mesa, CA 92626</B></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center">(Name, address and telephone number of
            agent for service)</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center">Email: tpoletti@manatt.com</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center"> </TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: center">Telephone: (714) 371-2500</TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated
         filer, a non-accelerated filer, a smaller reporting company or an emerging growth
         company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller
         reporting company&rdquo; and &ldquo;emerging growth company&rdquo; in Rule&nbsp;12b-2 of the Exchange Act.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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    <TD STYLE="text-align: left; width: 22%"><FONT STYLE="font-family: Times New Roman, Times, Serif">Large accelerated filer</FONT></TD>
    <TD STYLE="text-align: left; width: 28%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></TD>
    <TD STYLE="text-align: left; width: 25%"><FONT STYLE="font-family: Times New Roman, Times, Serif">Accelerated filer</FONT></TD>
    <TD STYLE="text-align: left; width: 25%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">Non-accelerated filer</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">Smaller reporting company</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">Emerging growth company</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">If an emerging growth company, indicate by check mark if the registrant has elected
         not to use the extended transition period for complying with any new or revised financial
         accounting standards provided pursuant to Section&nbsp;7(a)(2)(B) of the Securities Act. &#9744;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>PART I</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The documents containing the information specified in &ldquo;Item 1. Plan Information&rdquo; and
         in &ldquo;Item 2. Registrant Information and Employee Plan Annual information&rdquo; of Form S-8 will be sent or given to participants in the NeOnc Technologies Holdings, Inc. 2023 Equity Incentive Plan as specified by Rule&nbsp;428(b)(1) under the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;).</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Such documents are not required to be, and are not, filed with the Securities and
         Exchange Commission (the &ldquo;SEC&rdquo;) either as part of this Registration Statement or as
         a prospectus or prospectus supplement pursuant to Rule&nbsp;424 under the Securities Act. These documents and the documents incorporated by reference
         in this Registration Statement pursuant to Item 3 of Part II of Form S-8, taken together, constitute a prospectus that meets the requirements of Section&nbsp;10(a) of the Securities Act.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>PART II</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.5in; text-align: left"><B>Item 3.</B></TD><TD STYLE="text-align: justify"><B>Incorporation of Documents by Reference.</B></TD>
</TR></TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The Registrant hereby incorporates by reference into this Registration Statement the
         following documents filed by it with the SEC:</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.5in">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.25in">(a)</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: justify">The prospectus filed by the Registrant pursuant to Rule&nbsp;424(b)(4) of the Securities Act with the SEC on March 25, 2025 relating to the registration statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1979414/000182912625001228/neonctechnologies_s1a.htm">Form S-1, as amended (File No. 333-284115)</A>, and the registration statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1979414/000182912625000013/neonctechnologies_s1.htm">Form S-1 (File No. 333-284115)</A> which contains the Registrant&rsquo;s audited financial statements for the latest fiscal year for which such statements
               have been filed;</TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.5in">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.25in">(b)</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: justify">All other reports filed by the Registrant pursuant to Section&nbsp;13(a) or 15(d) of the Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;) since the end of the year covered by the latest prospectus
               filed by the Company referred in (a) above; and</TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.5in">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.25in">(c)</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: justify">The description of the Registrant&rsquo;s Common Stock contained in the Registration Statement on <A HREF="http://www.sec.gov/Archives/edgar/data/1979414/000182912625002032/neonctech_8a12b.htm">Form 8-A</A> (File No. 001-42567) filed with the SEC under Section&nbsp;12(b) of the Exchange Act on March 24, 2025, including any amendments or reports filed for the purpose of updating such description.</TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">All documents subsequently filed by the Registrant with the SEC pursuant to Sections&nbsp;13(a), 13(c), 14, or 15(d) of the Exchange Act after the date hereof, and prior to the filing of a post-effective
         amendment which indicates that all securities offered hereby have been sold or which
         deregisters all securities then remaining unsold, shall be deemed incorporated by
         reference into this Registration Statement and to be a part thereof from the date
         of the filing of such documents. Any statement contained in the documents incorporated,
         or deemed to be incorporated, by reference herein or therein shall be deemed to be
         modified or superseded for purposes of this Registration Statement and the prospectus
         to the extent that a statement contained herein or therein or in any other subsequently
         filed document which also is, or is deemed to be, incorporated by reference herein
         or therein modifies or supersedes such statement. Any such statement so modified or
         superseded shall not be deemed, except as so modified or superseded, to constitute
         a part of this Registration Statement and the prospectus.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Under no circumstances shall any information furnished under Item 2.02 or 7.01 of
         Form 8-K be deemed incorporated herein by reference unless such Form 8-K expressly provides to the contrary.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.5in"><B>Item 4.</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top"><B>Description of Securities</B></TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Not applicable.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.5in"><B>Item 5.</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: justify"><B>Interests of Named Experts and Counsel.</B></TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Not applicable.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.5in"><B>Item 6.</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; text-align: justify"><B>Indemnification of Directors and Officers.</B></TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The Registrant is incorporated under the laws of the State of Delaware.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The Registrant is governed by the Delaware General Corporation Law, as the same exists
         or may hereafter be amended (the General Corporation Law&rdquo;). Section&nbsp;145 of the General Corporation Law (&ldquo;Section&nbsp;145&rdquo;) provides that a Delaware corporation may indemnify any person who was or is a
         party or is threatened to be made a party to any threatened, pending or completed
         action, suit or proceeding, whether civil, criminal, administrative or investigative
         (other than an action by or in the right of such corporation) by reason of the fact
         that such person is or was a director, officer, employee or agent of such corporation,
         or is or was serving at the request of such corporation as a director, officer, employee
         or agent of another corporation or enterprise. The indemnification may include expenses
         (including attorneys&rsquo; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred
         by such person in connection with such action, suit or proceeding, provided such person
         acted in good faith and in a manner he or she reasonably believed to be in or not
         opposed to the corporation&rsquo;s best interests and, with respect to any criminal action or proceeding, had no reasonable
         cause to believe that his conduct was unlawful. Section&nbsp;145 also provides that a Delaware corporation may indemnify any person who was or is
         a party or is threatened to be made a party to any threatened, pending or completed
         action or suit by or in the right of such corporation, under the same conditions,
         except that such indemnification is limited to expenses (including attorneys&rsquo; fees) actually and reasonably incurred by such person, and except that no indemnification
         is permitted without judicial approval if such person is adjudged to be liable to
         such corporation. Where an officer or director of a corporation is successful, on
         the merits or otherwise, in the defense of any action, suit or proceeding referred
         to above, or any claim, issue or matter therein, the corporation must indemnify that
         person against the expenses (including attorneys&rsquo; fees) which such officer or director actually and reasonably incurred in connection
         therewith.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Section&nbsp;145 further authorizes a corporation to purchase and maintain insurance on behalf of
         any person who is or was a director, officer, employee or agent of the corporation,
         or is or was serving at the request of the corporation as a director, officer, employee
         or agent of another corporation or enterprise, against any liability asserted against
         such person and incurred by such person in any such capacity, or arising out of such
         person&rsquo;s status as such, whether or not the corporation would otherwise have the power to
         indemnify such person against such liability under Section&nbsp;145.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The Registrant&rsquo;s Amended and Restated Certificate of Incorporation provides that the Registrant may
         indemnify the directors and officers of the Corporation to the fullest extent permitted by law.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The Registrant&rsquo;s Bylaws provide that the Registrant shall indemnify and hold harmless to the fullest
         extent permitted by applicable law any person who was or is made or is threatened
         to be made a party or is otherwise involuntarily involved in any action, suit, or proceeding, whether civil, criminal, administrative,
         or investigative, by reason of the fact that such person, or a person for whom such
         person is the legal representative, is or was a director, or officer, or employee,
         or agent of the Registrant or, while a director, or officer, or employee, or agent
         of the Registrant, is or was serving at the request of the Registrant as a director,
         officer, employee, or agent of another corporation, partnership, joint venture, trust, or other enterprise, against all liability and loss suffered and expenses (including attorneys&rsquo; fees) actually and reasonably incurred by such person.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The Registrant&rsquo;s Amended and Restated Certificate of Incorporation eliminates the liability of a
         director or officer of the Registrant to the fullest extent under applicable law. Pursuant to Section&nbsp;102(b)(7) of the General Corporation Law, a corporation may eliminate the personal liability
         of a director to the corporation or its stockholders for monetary damages for breach
         of fiduciary duty as a director, except for liabilities arising (i) from any breach of the director&rsquo;s duty of loyalty to the corporation or its stockholders, (ii) from acts or omissions not in good faith or which involve intentional misconduct or
         a knowing violation of law, (iii) under Section&nbsp;174 of the General Corporation Law, (iv) from any transaction from which the director derived an improper personal benefit, or (v) an officer in any action by or in the right of the corporation.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B><I>Indemnification Agreements</I></B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The Registrant has entered into agreements with its directors and officers providing
         indemnification of such directors and officers by the Registrant to the fullest extent
         permitted by law, subject to certain limited exceptions. These agreements provide
         that the Registrant will indemnify each of our directors and officers to the fullest
         extent permitted by Delaware law. The Registrant will advance all expenses incurred
         by the indemnified director or officer (&ldquo;Indemnitee&rdquo;) in connection with any proceeding
         to which the Indemnitee is a party or is threatened to be made a party by reason of
         the fact that the Indemnitee is or was an agent of the Company or by reason of anything
         done or not done by the Indemnitee in any such capacity.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B><I>Directors&rsquo; and Officers&rsquo; Liability Insurance</I></B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The Registrant&rsquo;s directors and executive officers are covered by insurance maintained by the Registrant
         against specified liabilities for actions taken in their capacities as such, including
         liabilities under the Securities Act.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.5in"><B>Item 7.</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top"><B>Exemption From Registration Claimed.</B></TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Not applicable.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.5in"><B>Item 8. </B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top"><B>Exhibits.</B></TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; width: 9%; vertical-align: bottom"><B>Exhibit
            Number</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; width: 90%; border-bottom: Black 1pt solid; text-align: center; vertical-align: bottom"><B>Description</B></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">4.1</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom"><A HREF="http://www.sec.gov/Archives/edgar/data/1979414/000182912625000013/neonctechnologies_ex4-1.htm">Form Common Stock Certificate (incorporated by reference to Exhibit 4.1 of the Registrant&rsquo;s registration statement on Form S-1 filed January&nbsp;3, 2025)</A></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">5.1 </TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom"><A HREF="neonctechnologies_ex5-1.htm">Opinion of Manatt, Phelps &amp; Phillips LLP</A></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">23.1</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom"><A HREF="neonctechnologies_ex5-1.htm">Consent of Manatt, Phelps &amp; Phillips, LLP (contained in Exhibit 5.1)</A></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">23.2</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom"><A HREF="neonctechnologies_ex23-2.htm">Consent of Marcum LLP, independent registered public accounting firm</A></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">24.1 </TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom"><A HREF="#poa">Power of Attorney (contained on signature page hereto)</A></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">99.1</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom"><A HREF="neonctechnologies_ex99-1.htm">NeOnc Technologies Holdings, Inc. 2023 Equity Incentive Plan</A> </TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">99.2</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom"><A HREF="neonctechnologies_ex99-2.htm">First Amendment to the NeOnc Technologies Holdings, Inc. 2023 Equity Incentive Plan</A></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: White">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif; background-color: rgb(204,238,255)">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top">107</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; text-align: justify; vertical-align: bottom"><A HREF="neonctechnologies_ex107.htm">Calculation of Filing Fee Table</A></TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; width: 0.5in; background-color: #FFFFFF"><B>Item 9.</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: top; background-color: #FFFFFF"><B>Undertakings</B></TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">A. The undersigned Registrant hereby undertakes:</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(1) To file, during any period in which offers or sales are being made, a post-effective
         amendment to this registration statement:</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">(i) To include any prospectus required by section&nbsp;10(a)(3) of the Securities Act;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">(ii) To reflect in the prospectus any facts or events arising after the effective date
         of the registration statement (or the most recent post-effective amendment thereof)
         which, individually or in the aggregate, represent a fundamental change in the information
         set forth in the registration statement. Notwithstanding the foregoing, any increase
         or decrease in volume of securities offered (if the total dollar value of securities
         offered would not exceed that which was registered) and any deviation from the low
         or high end of the estimated maximum offering range may be reflected in the form of
         prospectus filed with the Commission pursuant to Rule&nbsp;424(b) if, in the aggregate, the changes in volume and price represent no more than a 20%
         change in the maximum aggregate offering price set forth in the &ldquo;Calculation of Registration
         Fee&rdquo; table in the effective registration statement; and</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify">(iii) To include any material information with respect to the plan of distribution not previously
         disclosed in the registration statement or any material change to such information
         in the registration statement.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><I>Provided, however,</I> that paragraphs A(1)(i) and A(1)(ii) do not apply if the information required to be included in a post-effective amendment
         by those paragraphs is contained in reports filed with or furnished to the Commission
         by the Registrant pursuant to section&nbsp;13 or section&nbsp;15(d) of the Exchange Act that are incorporated by reference in the registration statement.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
         statement relating to the securities offered herein, and the offering of such securities
         at that time shall be deemed to be the initial bona fide offering thereof.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(3) To remove from registration by means of a post-effective amendment any of the securities
         being registered which remain unsold at the termination of the offering.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">B. The undersigned Registrant hereby undertakes that, for purposes of determining
         any liability under the Securities Act, each filing of the Registrant&rsquo;s annual report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan&rsquo;s annual report pursuant to section&nbsp;15(d) of the Exchange Act) that is incorporated by reference in the registration statement
         shall be deemed to be a new registration statement relating to the securities offered
         herein, and the offering of such securities at that time shall be deemed to be the
         initial bona fide offering thereof.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">C. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant
         pursuant to the foregoing provisions, or otherwise, the Registrant has been advised
         that in the opinion of the Commission such indemnification is against public policy
         as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against
         such liabilities (other than the payment by the Registrant of expenses incurred or
         paid by a director, officer or controlling person of the Registrant in the successful
         defense of any action, suit or proceeding) is asserted by such director, officer or
         controlling person in connection with the securities being registered, the Registrant
         will, unless in the opinion of its counsel the matter has been settled by controlling
         precedent, submit to a court of appropriate jurisdiction the question whether such
         indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SIGNATURES</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Pursuant to the requirements of the Securities Act, the Registrant certifies that
         it has reasonable grounds to believe that it meets all of the requirements for filing
         on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
         the undersigned, thereunto duly authorized, in the City of Los Angeles, State of California, on March&nbsp;25, 2025.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; vertical-align: bottom">&nbsp;</TD>
            <TD COLSPAN="2" STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom"><B>NeOnc Technologies Holdings, Inc.</B></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; vertical-align: bottom">&nbsp;</TD>
            <TD COLSPAN="2" STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; width: 50%; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; width: 4%; vertical-align: bottom">By:</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; width: 45%; border-bottom: Black 1pt solid; vertical-align: bottom">/s/ Dr. Thomas C. Chen</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; white-space: nowrap; vertical-align: bottom">Name: </TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; vertical-align: bottom">Dr. Thomas Chen</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; vertical-align: bottom">Title: </TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom; vertical-align: bottom">Chief Executive Officer</TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B><A NAME="poa"></A>POWER OF ATTORNEY</B></P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">We, the undersigned officers and directors of NeOnc Technologies Holdings, Inc., do hereby constitute and appoint Dr. Thomas C. Chen and Keithly Garnett, and each of them, as his true and lawful attorneys-in-fact and agents, with full
         power of substitution for him in any and all capacities, to sign any and all amendments
         (including post-effective amendments) to this Registration Statement, and to file
         the same, with all exhibits thereto, and other documents in connection therewith,
         with the Securities and Exchange Commission, granting unto said attorneys-in-fact
         and agents, and each of them, full power and authority to do and perform each and
         every act and thing requisite and necessary to be done in connection therewith, as
         fully to all intents and purposes as he might or could do in person, hereby ratifying
         and confirming all that said attorneys-in-fact and agents, or any of them, or their
         or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Pursuant to the requirements of the Securities Act, this Registration Statement has
         been signed by the following persons in the capacities and on the dates indicated.</P>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
      <TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 40%; text-align: center; vertical-align: bottom"><B>Name and Signature</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%; text-align: center; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 40%; text-align: center; vertical-align: bottom"><B>Title</B></TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: middle; width: 2%; text-align: center; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 16%; text-align: center; vertical-align: bottom"><B>Date</B></TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; vertical-align: bottom">/s/ Dr. Thomas C. Chen</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">Chief Executive Officer and Chairman</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">March 25, 2025</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">Dr. Thomas C. Chen</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">(<I>Principal Executive Officer</I>)</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; vertical-align: bottom">/s/ Keithly Garnett </TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">Chief Financial Officer </TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">March 25, 2025</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">Keithly Garnett</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">(<I>Principal Financial Officer</I>)</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; vertical-align: bottom">/s/ Amir Heshmatpour</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">Executive Chairman and Secretary</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">March 25, 2025</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">Amir Heshmatpour</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; vertical-align: bottom">/s/ Dr. Ming-Fu Chiang</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">Director</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">March 25, 2025</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">Dr. Ming-Fu Chiang</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD></TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; vertical-align: bottom">
               <P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0">/s/ Victoria Medvec</P>
            </TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">Director</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">March 25, 2025</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">Victoria Medvec </TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD></TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; vertical-align: bottom">
               <P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0">/s/ Dr. Steven L. Giannotta</P>
            </TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">Director</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">March 25, 2025</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">Dr. Steven L. Giannotta</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD></TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; vertical-align: bottom">
               <P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin: 0">/s/ Bader Al Monawer</P>
            </TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">Director</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">March 25, 2025</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">Bader Al Monawer</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; vertical-align: bottom">/s/ Jim Delshad</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">Director</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; vertical-align: middle; text-align: left; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">March 25, 2025</TD>
         </TR>
         <TR STYLE="font: 10pt Times New Roman, Times, Serif">
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">Jim Delshad</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: bottom">&nbsp;</TD>
            <TD STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; vertical-align: middle; vertical-align: middle">&nbsp;</TD>
            <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; vertical-align: middle">&nbsp;</TD>
         </TR>
      </TABLE>
      <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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{"company-data": {"conformed-name": "NEONC TECHNOLOGIES HOLDINGS, INC.", "cik": "0001979414", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "ein": "921954864", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-286102", "film-number": "25769446"}, "business-address": {"street1": "2 DOLE DRIVE", "city": "WESTLAKE VILLAGE", "state": "CA", "zip": "91362", "phone": "310 663 7831"}, "mail-address": {"street1": "2 DOLE DRIVE", "city": "WESTLAKE VILLAGE", "state": "CA", "zip": "91362"}}
As filed with the Securities and Exchange Commission on March 25, 2025
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
NEONC TECHNOLOGIES
      HOLDINGS, INC.
(Exact name of registrant as specified in its charter)
Delaware
92-1954864
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
2 Dole Drive
Westlake Village, CA 91362
(Address of principal executive offices)
(310) 663-7831
(Registrant's telephone number, including area code)
NeOnc Technologies Holdings, Inc. 2023 Equity
Incentive Plan
(Full title of the plan)
Copy to:
Dr. Thomas C. Chen
Thomas J. Poletti, Esq.
Chief Executive Officer
Veronica Lah, Esq.
2 Dole Drive
Manatt, Phelps & Phillips, LLP
Westlake Village, CA 91362
695 Town Center Drive, 14
th
Floor
(310) 663-7831
Costa Mesa, CA 92626
(Name, address and telephone number of
            agent for service)
Email: tpoletti@manatt.com
Telephone: (714) 371-2500
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated
         filer, a non-accelerated filer, a smaller reporting company or an emerging growth
         company. See the definitions of "large accelerated filer," "accelerated filer," "smaller
         reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☒
If an emerging growth company, indicate by check mark if the registrant has elected
         not to use the extended transition period for complying with any new or revised financial
         accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
The documents containing the information specified in "Item 1. Plan Information" and
         in "Item 2. Registrant Information and Employee Plan Annual information" of Form S-8 will be sent or given to participants in the NeOnc Technologies Holdings, Inc. 2023 Equity Incentive Plan as specified by Rule 428(b)(1) under the Securities Act of 1933, as amended (the "Securities Act").
Such documents are not required to be, and are not, filed with the Securities and
         Exchange Commission (the "SEC") either as part of this Registration Statement or as
         a prospectus or prospectus supplement pursuant to Rule 424 under the Securities Act. These documents and the documents incorporated by reference
         in this Registration Statement pursuant to Item 3 of Part II of Form S-8, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.
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PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The Registrant hereby incorporates by reference into this Registration Statement the
         following documents filed by it with the SEC:
(a)
The prospectus filed by the Registrant pursuant to Rule 424(b)(4) of the Securities Act with the SEC on March 25, 2025 relating to the registration statement on
Form S-1, as amended (File No. 333-284115)
, and the registration statement on
Form S-1 (File No. 333-284115)
which contains the Registrant's audited financial statements for the latest fiscal year for which such statements
               have been filed;
(b)
All other reports filed by the Registrant pursuant to Section 13(a) or 15(d) of the Exchange Act of 1934, as amended (the "Exchange Act") since the end of the year covered by the latest prospectus
               filed by the Company referred in (a) above; and
(c)
The description of the Registrant's Common Stock contained in the Registration Statement on
Form 8-A
(File No. 001-42567) filed with the SEC under Section 12(b) of the Exchange Act on March 24, 2025, including any amendments or reports filed for the purpose of updating such description.
All documents subsequently filed by the Registrant with the SEC pursuant to Sections 13(a), 13(c), 14, or 15(d) of the Exchange Act after the date hereof, and prior to the filing of a post-effective
         amendment which indicates that all securities offered hereby have been sold or which
         deregisters all securities then remaining unsold, shall be deemed incorporated by
         reference into this Registration Statement and to be a part thereof from the date
         of the filing of such documents. Any statement contained in the documents incorporated,
         or deemed to be incorporated, by reference herein or therein shall be deemed to be
         modified or superseded for purposes of this Registration Statement and the prospectus
         to the extent that a statement contained herein or therein or in any other subsequently
         filed document which also is, or is deemed to be, incorporated by reference herein
         or therein modifies or supersedes such statement. Any such statement so modified or
         superseded shall not be deemed, except as so modified or superseded, to constitute
         a part of this Registration Statement and the prospectus.
Under no circumstances shall any information furnished under Item 2.02 or 7.01 of
         Form 8-K be deemed incorporated herein by reference unless such Form 8-K expressly provides to the contrary.
Item 4.
Description of Securities
Not applicable.
Item 5.
Interests of Named Experts and Counsel.
Not applicable.
Item 6.
Indemnification of Directors and Officers.
The Registrant is incorporated under the laws of the State of Delaware.
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The Registrant is governed by the Delaware General Corporation Law, as the same exists
         or may hereafter be amended (the General Corporation Law"). Section 145 of the General Corporation Law ("Section 145") provides that a Delaware corporation may indemnify any person who was or is a
         party or is threatened to be made a party to any threatened, pending or completed
         action, suit or proceeding, whether civil, criminal, administrative or investigative
         (other than an action by or in the right of such corporation) by reason of the fact
         that such person is or was a director, officer, employee or agent of such corporation,
         or is or was serving at the request of such corporation as a director, officer, employee
         or agent of another corporation or enterprise. The indemnification may include expenses
         (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred
         by such person in connection with such action, suit or proceeding, provided such person
         acted in good faith and in a manner he or she reasonably believed to be in or not
         opposed to the corporation's best interests and, with respect to any criminal action or proceeding, had no reasonable
         cause to believe that his conduct was unlawful. Section 145 also provides that a Delaware corporation may indemnify any person who was or is
         a party or is threatened to be made a party to any threatened, pending or completed
         action or suit by or in the right of such corporation, under the same conditions,
         except that such indemnification is limited to expenses (including attorneys' fees) actually and reasonably incurred by such person, and except that no indemnification
         is permitted without judicial approval if such person is adjudged to be liable to
         such corporation. Where an officer or director of a corporation is successful, on
         the merits or otherwise, in the defense of any action, suit or proceeding referred
         to above, or any claim, issue or matter therein, the corporation must indemnify that
         person against the expenses (including attorneys' fees) which such officer or director actually and reasonably incurred in connection
         therewith.
Section 145 further authorizes a corporation to purchase and maintain insurance on behalf of
         any person who is or was a director, officer, employee or agent of the corporation,
         or is or was serving at the request of the corporation as a director, officer, employee
         or agent of another corporation or enterprise, against any liability asserted against
         such person and incurred by such person in any such capacity, or arising out of such
         person's status as such, whether or not the corporation would otherwise have the power to
         indemnify such person against such liability under Section 145.
The Registrant's Amended and Restated Certificate of Incorporation provides that the Registrant may
         indemnify the directors and officers of the Corporation to the fullest extent permitted by law.
The Registrant's Bylaws provide that the Registrant shall indemnify and hold harmless to the fullest
         extent permitted by applicable law any person who was or is made or is threatened
         to be made a party or is otherwise involuntarily involved in any action, suit, or proceeding, whether civil, criminal, administrative,
         or investigative, by reason of the fact that such person, or a person for whom such
         person is the legal representative, is or was a director, or officer, or employee,
         or agent of the Registrant or, while a director, or officer, or employee, or agent
         of the Registrant, is or was serving at the request of the Registrant as a director,
         officer, employee, or agent of another corporation, partnership, joint venture, trust, or other enterprise, against all liability and loss suffered and expenses (including attorneys' fees) actually and reasonably incurred by such person.
The Registrant's Amended and Restated Certificate of Incorporation eliminates the liability of a
         director or officer of the Registrant to the fullest extent under applicable law. Pursuant to Section 102(b)(7) of the General Corporation Law, a corporation may eliminate the personal liability
         of a director to the corporation or its stockholders for monetary damages for breach
         of fiduciary duty as a director, except for liabilities arising (i) from any breach of the director's duty of loyalty to the corporation or its stockholders, (ii) from acts or omissions not in good faith or which involve intentional misconduct or
         a knowing violation of law, (iii) under Section 174 of the General Corporation Law, (iv) from any transaction from which the director derived an improper personal benefit, or (v) an officer in any action by or in the right of the corporation.
Indemnification Agreements
The Registrant has entered into agreements with its directors and officers providing
         indemnification of such directors and officers by the Registrant to the fullest extent
         permitted by law, subject to certain limited exceptions. These agreements provide
         that the Registrant will indemnify each of our directors and officers to the fullest
         extent permitted by Delaware law. The Registrant will advance all expenses incurred
         by the indemnified director or officer ("Indemnitee") in connection with any proceeding
         to which the Indemnitee is a party or is threatened to be made a party by reason of
         the fact that the Indemnitee is or was an agent of the Company or by reason of anything
         done or not done by the Indemnitee in any such capacity.
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Directors' and Officers' Liability Insurance
The Registrant's directors and executive officers are covered by insurance maintained by the Registrant
         against specified liabilities for actions taken in their capacities as such, including
         liabilities under the Securities Act.
Item 7.
Exemption From Registration Claimed.
Not applicable.
Item 8.
Exhibits.
Exhibit
            Number
Description
4.1
Form Common Stock Certificate (incorporated by reference to Exhibit 4.1 of the Registrant's registration statement on Form S-1 filed January 3, 2025)
5.1
Opinion of Manatt, Phelps & Phillips LLP
23.1
Consent of Manatt, Phelps & Phillips, LLP (contained in Exhibit 5.1)
23.2
Consent of Marcum LLP, independent registered public accounting firm
24.1
Power of Attorney (contained on signature page hereto)
99.1
NeOnc Technologies Holdings, Inc. 2023 Equity Incentive Plan
99.2
First Amendment to the NeOnc Technologies Holdings, Inc. 2023 Equity Incentive Plan
107
Calculation of Filing Fee Table
Item 9.
Undertakings
A. The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a post-effective
         amendment to this registration statement:
(i) To include any prospectus required by section 10(a)(3) of the Securities Act;
(ii) To reflect in the prospectus any facts or events arising after the effective date
         of the registration statement (or the most recent post-effective amendment thereof)
         which, individually or in the aggregate, represent a fundamental change in the information
         set forth in the registration statement. Notwithstanding the foregoing, any increase
         or decrease in volume of securities offered (if the total dollar value of securities
         offered would not exceed that which was registered) and any deviation from the low
         or high end of the estimated maximum offering range may be reflected in the form of
         prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20%
         change in the maximum aggregate offering price set forth in the "Calculation of Registration
         Fee" table in the effective registration statement; and
(iii) To include any material information with respect to the plan of distribution not previously
         disclosed in the registration statement or any material change to such information
         in the registration statement.
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Provided, however,
that paragraphs A(1)(i) and A(1)(ii) do not apply if the information required to be included in a post-effective amendment
         by those paragraphs is contained in reports filed with or furnished to the Commission
         by the Registrant pursuant to section 13 or section 15(d) of the Exchange Act that are incorporated by reference in the registration statement.
(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
         statement relating to the securities offered herein, and the offering of such securities
         at that time shall be deemed to be the initial bona fide offering thereof.
(3) To remove from registration by means of a post-effective amendment any of the securities
         being registered which remain unsold at the termination of the offering.
B. The undersigned Registrant hereby undertakes that, for purposes of determining
         any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement
         shall be deemed to be a new registration statement relating to the securities offered
         herein, and the offering of such securities at that time shall be deemed to be the
         initial bona fide offering thereof.
C. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant
         pursuant to the foregoing provisions, or otherwise, the Registrant has been advised
         that in the opinion of the Commission such indemnification is against public policy
         as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against
         such liabilities (other than the payment by the Registrant of expenses incurred or
         paid by a director, officer or controlling person of the Registrant in the successful
         defense of any action, suit or proceeding) is asserted by such director, officer or
         controlling person in connection with the securities being registered, the Registrant
         will, unless in the opinion of its counsel the matter has been settled by controlling
         precedent, submit to a court of appropriate jurisdiction the question whether such
         indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
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SIGNATURES
Pursuant to the requirements of the Securities Act, the Registrant certifies that
         it has reasonable grounds to believe that it meets all of the requirements for filing
         on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by
         the undersigned, thereunto duly authorized, in the City of Los Angeles, State of California, on March 25, 2025.
NeOnc Technologies Holdings, Inc.
By:
/s/ Dr. Thomas C. Chen
Name:
Dr. Thomas Chen
Title:
Chief Executive Officer
POWER OF ATTORNEY
We, the undersigned officers and directors of NeOnc Technologies Holdings, Inc., do hereby constitute and appoint Dr. Thomas C. Chen and Keithly Garnett, and each of them, as his true and lawful attorneys-in-fact and agents, with full
         power of substitution for him in any and all capacities, to sign any and all amendments
         (including post-effective amendments) to this Registration Statement, and to file
         the same, with all exhibits thereto, and other documents in connection therewith,
         with the Securities and Exchange Commission, granting unto said attorneys-in-fact
         and agents, and each of them, full power and authority to do and perform each and
         every act and thing requisite and necessary to be done in connection therewith, as
         fully to all intents and purposes as he might or could do in person, hereby ratifying
         and confirming all that said attorneys-in-fact and agents, or any of them, or their
         or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has
         been signed by the following persons in the capacities and on the dates indicated.
Name and Signature
Title
Date
/s/ Dr. Thomas C. Chen
Chief Executive Officer and Chairman
March 25, 2025
Dr. Thomas C. Chen
(
Principal Executive Officer
)
/s/ Keithly Garnett
Chief Financial Officer
March 25, 2025
Keithly Garnett
(
Principal Financial Officer
)
/s/ Amir Heshmatpour
Executive Chairman and Secretary
March 25, 2025
Amir Heshmatpour
/s/ Dr. Ming-Fu Chiang
Director
March 25, 2025
Dr. Ming-Fu Chiang
/s/ Victoria Medvec
Director
March 25, 2025
Victoria Medvec
/s/ Dr. Steven L. Giannotta
Director
March 25, 2025
Dr. Steven L. Giannotta
/s/ Bader Al Monawer
Director
March 25, 2025
Bader Al Monawer
/s/ Jim Delshad
Director
March 25, 2025
Jim Delshad
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