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<TITLE>CV Therapeutics Form S-8</TITLE>
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<P align="center"><FONT size="2">As filed with the Securities and Exchange Commission on October&nbsp;2, 2002</FONT>

<DIV align="right"><FONT size="2">Registration No.&nbsp;333-________</FONT></DIV>

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<P align="center"><FONT size="5"><B>SECURITIES AND EXCHANGE COMMISSION</B></FONT>

<DIV align="center"><FONT size="2"><B>WASHINGTON, D.C. 20549</B></FONT></DIV>

<P align="center"><FONT size="5"><B>FORM S-8</B></FONT>

<DIV align="center"><FONT size="2"><B>REGISTRATION STATEMENT<BR>
Under<BR>
THE SECURITIES ACT OF 1933</B></FONT></DIV>

<P align="center"><FONT size="4"><B>CV THERAPEUTICS, INC.</B></FONT>

<DIV align="center"><FONT size="2"><B>(Exact name of Registrant as specified in its charter)</B></FONT></DIV>

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        <TD align="center" valign="top"><FONT size="2"><B>Delaware<BR>
(State or other jurisdiction of<BR>
incorporation or organization)</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>43-1570294<BR>
(I.R.S. Employer<BR>
Identification No.)</B></FONT></TD>
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<P align="center"><FONT size="2"><B>3172 Porter Drive<BR>
Palo Alto, California 94304<BR>
(650)&nbsp;384-8500<BR>
(Address of Principal Executive Offices including Zip Code)</B></FONT>

<P align="center"><FONT size="3"><B>CV Therapeutics, Inc. 2000 Nonstatutory Incentive Plan</B></FONT>

<DIV align="center"><FONT size="2"><B>(Full title of the plan)</B></FONT></DIV>

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        <TD align="center" valign="top"><FONT size="2"><B>Louis G. Lange, M.D., Ph.D.</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>Copy to:</B></FONT></TD>
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        <TD align="center" valign="top"><FONT size="2"><B>Chief Executive Officer<BR>
CV THERAPEUTICS, INC.<BR>
3172 Porter Drive<BR>
Palo Alto, California 94304<BR>
(650)&nbsp;384-8500</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
<B>Laura L. Gabriel, Esq.<BR>
LATHAM &#038; WATKINS<BR>
505 Montgomery Street, Suite&nbsp;1900<BR>
San Francisco, California 94111<BR>
(415)&nbsp;391-0600</B></FONT></TD>
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<P align="center"><FONT size="2"><B>(Name and address, including zip code, and telephone<BR>
number, including area code, of agent for service)</B></FONT>

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<TD  colspan="17"  align="center"><FONT size="1"><B>CALCULATION OF REGISTRATION FEE</B></FONT></TD>

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        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
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        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount To Be</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price Per</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate Offering</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount Of</B></FONT></TD>
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        <TD nowrap align="center"><FONT size="1"><B>Title Of Securities To Be Registered</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registered</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Share(2)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Price(2)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration Fee</B></FONT></TD>
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        <TD><FONT size="2">Common Stock, $0.001 par value,
issuable under the CV Therapeutics,
Inc. 2000 Nonstatutory Incentive
Plan (1)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">500,000</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">20.80</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">10,400,000</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="right"><FONT size="2">$</FONT></TD>
        <TD align="right"><FONT size="2">956.80</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
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<P><FONT size="2">(1)&nbsp; The CV Therapeutics, Inc. 2000 Nonstatutory Incentive Plan (the
&#147;Nonstatutory Plan&#148;) authorizes the issuance of a maximum of 2,610,325 shares,
of which 500,000 of the authorized shares are being registered hereunder.<br>
(2)&nbsp;Estimated for the purpose of calculating the registration fee pursuant to
Rule&nbsp;457(c) of the Securities Act of 1933, as amended (the &#147;Securities Act&#148;),
based on the average high and low prices for the Registrant&#146;s Common Stock at
$20.80 as reported on the Nasdaq National Market on September&nbsp;30, 2002.
</FONT>
<P><FONT size="2">Proposed sale to take place as soon after the effective date of the
Registration Statement as options under the Nonstatutory Plan are exercised.
</FONT>
<P>
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<P align="center"><FONT size="2">&nbsp;
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<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD colspan="9"><A HREF="#000">PART I</A></TD></TR>
<TR><TD colspan="9"><A HREF="#001">PART II</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item&nbsp;8. Exhibits</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#004">INDEX TO EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="f84708orexv4w1.txt">EXHIBIT 4.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="f84708orexv5w1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="f84708orexv23w2.txt">EXHIBIT 23.2</A></TD></TR>
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<!-- link1 "PART I" -->
<DIV align="left"><A NAME="000"></A></DIV>
<P align="center"><FONT size="2"><B>PART I</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The information called for in Part I of the Form&nbsp;S-8 is not being filed
with or included in this Form&nbsp;S-8 (by incorporation, by reference or otherwise)
in accordance with the rules and regulations of the Securities and Exchange
Commission (the &#147;Commission&#148;).
</FONT>
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<DIV align="left"><A NAME="001"></A></DIV>
<P align="center"><FONT size="2"><B>PART II</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;By a registration statement on Form&nbsp;S-8 filed with the Commission on
October&nbsp;31, 2000, Registration No.&nbsp;333-49026 (the &#147;First Nonstatutory Plan
Registration Statement&#148;), the Registrant previously registered 250,000 shares
of its Common Stock reserved for issuance from time to time in connection with
the Nonstatutory Plan. On February&nbsp;9, 2001, the Registrant&#146;s Board of
Directors authorized the amendment of the Nonstatutory Plan to increase the
number of shares of Common Stock issuable thereunder by 350,000 shares to a
total of 600,000 shares. By a registration statement on Form&nbsp;S-8 filed with
the Commission on May&nbsp;7, 2001, Registration No.&nbsp;333-60358 (the &#147;Second
Nonstatutory Plan Registration Statement&#148;), the Registrant registered an
additional 350,000 shares of Common Stock issuable under the Nonstatutory Plan.
On July&nbsp;20, 2001, the Registrant&#146;s Board of Directors authorized the amendment
of the Nonstatutory Plan to increase the number of shares of Common Stock
issuable thereunder by 250,000 shares to a total of 850,000 shares. By a
registration statement on Form&nbsp;S-8 filed with the Commission on September&nbsp;5,
2001, Registration Statement No.&nbsp;333-68984 (the &#147;Third Nonstatutory Plan
Registration Statement&#148;), the Registrant registered an additional 250,000
shares of Common Stock issuable under the Nonstatutory Plan. On December&nbsp;9,
2001, February&nbsp;25, 2002, and June&nbsp;7, 2002, the Registrant&#146;s Board of Directors
authorized the amendment of the Nonstatutory Plan to increase the number of
shares of Common Stock issuable thereunder by 285,325 shares, 200,000 shares
and 775,000 shares, respectively, to a total of 2,110,325 shares. By a
registration statement on Form&nbsp;S-8 filed with the Commission on August&nbsp;15,
2002, Registration Statement No.&nbsp;333-98195 (the &#147;Fourth Nonstatutory Plan
Registration Statement&#148;), the Registrant registered an additional 1,260,325
shares of Common Stock issuable under the Nonstatutory Plan. On August&nbsp;29,
2002, the Registrant&#146;s Board of Directors authorized the amendment of the
Nonstatutory Plan to increase the number of shares of Common Stock issuable
thereunder by 500,000 shares, to a total of 2,610,325 shares. The Registrant
is hereby registering an additional 500,000 shares of Common Stock issuable
under the Nonstatutory Plan.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to General Instruction E of Form&nbsp;S-8, the contents of the First
Nonstatutory Plan Registration Statement, the Second Nonstatutory Plan
Registration Statement, the Third Nonstatutory Plan Registration Statement and
the Fourth Nonstatutory Plan Registration Statement are incorporated by
reference herein with such modifications as are set forth herein.
</FONT>
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<DIV align="left"><A NAME="002"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;See the Exhibit&nbsp;Index on Page 5.
</FONT>
<P align="center"><FONT size="2">2
</FONT>

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<DIV align="left"><A NAME="003"></A></DIV>
<P align="center"><FONT size="2"><B>SIGNATURES</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1993, as amended
(the &#147;Securities Act&#148;), the Registrant certifies that it has reasonable grounds
to believe that it meets all of the requirements for filing on Form&nbsp;S-8 and has
duly caused this Registration Statement to be signed on its behalf by the
undersigned thereunto duly authorized, in the city of Palo Alto, County of
Santa Clara, State of California, on the 2nd day of October, 2002.
</FONT>
<P>
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        <TD width="50%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="50%"><FONT size="2">CV THERAPEUTICS, INC.</FONT></TD>
</TR>
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By:
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">/S/&nbsp; DANIEL K. SPIEGELMAN</FONT></TD>
</TR>
<TR>
        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><HR size="1" noshade></TD>
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        <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">Daniel K. Spiegelman<br>
<I>Senior Vice President and Chief Financial Officer</I><br>
(Principal financial and accounting officer)</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B></FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints LOUIS G. LANGE and DANIEL K. SPIEGELMAN,
jointly and severally, his or her attorneys-in-fact and agents, each with power
of substitution and resubstitution, for him or her and in his or her name,
place or stead, in any and all capacities, to sign any amendments to this
Registration Statement on Form&nbsp;S-8, and to file such amendments, together with
exhibits and other documents in connection therewith, with the Securities and
Exchange Commission, granting to each attorney-in-fact and agent, full power
and authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully as he or she might or
could do in person, and ratifying and confirming all that the attorney-in-fact
and agents, or his or her substitute or substitutes, may do or cause to be done
by virtue hereof.
</FONT>
<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed by the following persons in the capacities and on the
dates indicated.
</FONT>
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        <TD nowrap align="center"><FONT size="1"><B>Signatures</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
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        <TD valign="top"  align="center"><FONT size="2">/S/&nbsp; LOUIS G. LANGE
<HR size="1" noshade>
Louis G. Lange, M.D., Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Chairman of the Board and<BR>
Chief Executive Officer<BR>
(Principal executive officer)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">October&nbsp;2, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">/S/&nbsp; DANIEL K. SPIEGELMAN
<HR size="1" noshade>
Daniel K. Spiegelman</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Chief Financial Officer
(Principal<BR> financial and
accounting officer)
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">October&nbsp;2, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

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        <TD valign="top"  align="center"><FONT size="2">/S/&nbsp; SANTO J. COSTA
<HR size="1" noshade>
Santo J. Costa</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">October&nbsp;2, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

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        <TD valign="top"  align="center"><FONT size="2">/S/&nbsp; R. SCOTT GREER
<HR size="1" noshade>
R. Scott Greer</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">October&nbsp;2, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">/S/&nbsp; JOHN GROOM
<HR size="1" noshade>
John Groom</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">October&nbsp;2, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">/S/&nbsp; THOMAS L. GUTSHALL
<HR size="1" noshade>
Thomas L. Gutshall</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">October&nbsp;2, 2002</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">3
</FONT>

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        <TD nowrap align="center"><FONT size="1"><B>Signatures</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
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<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">/S/&nbsp; PETER BARTON HUTT
<HR size="1" noshade>
Peter Barton Hutt</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">October&nbsp;2, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">/S/&nbsp; KENNETH B. LEE, JR.
<HR size="1" noshade>
Kenneth B. Lee, Jr.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">October&nbsp;2, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">/S/&nbsp; BARBARA J. MCNEIL
<HR size="1" noshade>
Barbara J. McNeil, M.D., Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">October&nbsp;2, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">/S/&nbsp; COSTA G. SEVASTOPOULOS
<HR size="1" noshade>
Costa G. Sevastopoulos, Ph.D.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
Director
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">October&nbsp;2, 2002</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">4
</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "INDEX TO EXHIBITS" -->
<DIV align="left"><A NAME="004"></A></DIV>
<P align="center"><FONT size="2"><B>INDEX TO EXHIBITS</B></FONT>

<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="8%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
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        <TD width="1%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1"><B>EXHIBIT</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>DESCRIPTION</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
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        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">4.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
CV Therapeutics, Inc. 2000 Nonstatutory Incentive Plan, as amended.</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">5.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Opinion of Latham &#038; Watkins.</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">23.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Latham &#038; Watkins (included in Exhibit&nbsp;5.1 hereto)</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">23.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Consent of Ernst &#038; Young LLP, Independent Auditors.</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD valign="top"  align="center"><FONT size="2">24.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Power of Attorney (included on the signature page to this
Registration Statement)</FONT></TD>
</TR>
</TABLE>

<P align="center"><FONT size="2">5</FONT>


</BODY>
</HTML>
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CV Therapeutics Form S-8
Table of Contents
As filed with the Securities and Exchange Commission on October 2, 2002
Registration No. 333-________
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
THE SECURITIES ACT OF 1933
CV THERAPEUTICS, INC.
(Exact name of Registrant as specified in its charter)
Delaware
(State or other jurisdiction of
incorporation or organization)
43-1570294
(I.R.S. Employer
Identification No.)
3172 Porter Drive
Palo Alto, California 94304
(650) 384-8500
(Address of Principal Executive Offices including Zip Code)
CV Therapeutics, Inc. 2000 Nonstatutory Incentive Plan
(Full title of the plan)
Louis G. Lange, M.D., Ph.D.
Copy to:
Chief Executive Officer
CV THERAPEUTICS, INC.
3172 Porter Drive
Palo Alto, California 94304
(650) 384-8500
Laura L. Gabriel, Esq.
LATHAM & WATKINS
505 Montgomery Street, Suite 1900
San Francisco, California 94111
(415) 391-0600
(Name and address, including zip code, and telephone
number, including area code, of agent for service)
CALCULATION OF REGISTRATION FEE
Proposed Maximum
Proposed Maximum
Amount To Be
Offering Price Per
Aggregate Offering
Amount Of
Title Of Securities To Be Registered
Registered
Share(2)
Price(2)
Registration Fee
Common Stock, $0.001 par value,
issuable under the CV Therapeutics,
Inc. 2000 Nonstatutory Incentive
Plan (1)
500,000
$
20.80
$
10,400,000
$
956.80
(1)  The CV Therapeutics, Inc. 2000 Nonstatutory Incentive Plan (the
"Nonstatutory Plan") authorizes the issuance of a maximum of 2,610,325 shares,
of which 500,000 of the authorized shares are being registered hereunder.
(2) Estimated for the purpose of calculating the registration fee pursuant to
Rule 457(c) of the Securities Act of 1933, as amended (the "Securities Act"),
based on the average high and low prices for the Registrant's Common Stock at
$20.80 as reported on the Nasdaq National Market on September 30, 2002.
Proposed sale to take place as soon after the effective date of the
Registration Statement as options under the Nonstatutory Plan are exercised.
TABLE OF CONTENTS
PART I
PART II
Item 8. Exhibits
SIGNATURES
INDEX TO EXHIBITS
EXHIBIT 4.1
EXHIBIT 5.1
EXHIBIT 23.2
Table of Contents
PART I
The information called for in Part I of the Form S-8 is not being filed
with or included in this Form S-8 (by incorporation, by reference or otherwise)
in accordance with the rules and regulations of the Securities and Exchange
Commission (the "Commission").
PART II
By a registration statement on Form S-8 filed with the Commission on
October 31, 2000, Registration No. 333-49026 (the "First Nonstatutory Plan
Registration Statement"), the Registrant previously registered 250,000 shares
of its Common Stock reserved for issuance from time to time in connection with
the Nonstatutory Plan. On February 9, 2001, the Registrant's Board of
Directors authorized the amendment of the Nonstatutory Plan to increase the
number of shares of Common Stock issuable thereunder by 350,000 shares to a
total of 600,000 shares. By a registration statement on Form S-8 filed with
the Commission on May 7, 2001, Registration No. 333-60358 (the "Second
Nonstatutory Plan Registration Statement"), the Registrant registered an
additional 350,000 shares of Common Stock issuable under the Nonstatutory Plan.
On July 20, 2001, the Registrant's Board of Directors authorized the amendment
of the Nonstatutory Plan to increase the number of shares of Common Stock
issuable thereunder by 250,000 shares to a total of 850,000 shares. By a
registration statement on Form S-8 filed with the Commission on September 5,
2001, Registration Statement No. 333-68984 (the "Third Nonstatutory Plan
Registration Statement"), the Registrant registered an additional 250,000
shares of Common Stock issuable under the Nonstatutory Plan. On December 9,
2001, February 25, 2002, and June 7, 2002, the Registrant's Board of Directors
authorized the amendment of the Nonstatutory Plan to increase the number of
shares of Common Stock issuable thereunder by 285,325 shares, 200,000 shares
and 775,000 shares, respectively, to a total of 2,110,325 shares. By a
registration statement on Form S-8 filed with the Commission on August 15,
2002, Registration Statement No. 333-98195 (the "Fourth Nonstatutory Plan
Registration Statement"), the Registrant registered an additional 1,260,325
shares of Common Stock issuable under the Nonstatutory Plan. On August 29,
2002, the Registrant's Board of Directors authorized the amendment of the
Nonstatutory Plan to increase the number of shares of Common Stock issuable
thereunder by 500,000 shares, to a total of 2,610,325 shares. The Registrant
is hereby registering an additional 500,000 shares of Common Stock issuable
under the Nonstatutory Plan.
Pursuant to General Instruction E of Form S-8, the contents of the First
Nonstatutory Plan Registration Statement, the Second Nonstatutory Plan
Registration Statement, the Third Nonstatutory Plan Registration Statement and
the Fourth Nonstatutory Plan Registration Statement are incorporated by
reference herein with such modifications as are set forth herein.
Item 8. Exhibits
See the Exhibit Index on Page 5.
2
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1993, as amended
(the "Securities Act"), the Registrant certifies that it has reasonable grounds
to believe that it meets all of the requirements for filing on Form S-8 and has
duly caused this Registration Statement to be signed on its behalf by the
undersigned thereunto duly authorized, in the city of Palo Alto, County of
Santa Clara, State of California, on the 2nd day of October, 2002.
CV THERAPEUTICS, INC.
By:
/S/  DANIEL K. SPIEGELMAN
Daniel K. Spiegelman
Senior Vice President and Chief Financial Officer
(Principal financial and accounting officer)
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints LOUIS G. LANGE and DANIEL K. SPIEGELMAN,
jointly and severally, his or her attorneys-in-fact and agents, each with power
of substitution and resubstitution, for him or her and in his or her name,
place or stead, in any and all capacities, to sign any amendments to this
Registration Statement on Form S-8, and to file such amendments, together with
exhibits and other documents in connection therewith, with the Securities and
Exchange Commission, granting to each attorney-in-fact and agent, full power
and authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully as he or she might or
could do in person, and ratifying and confirming all that the attorney-in-fact
and agents, or his or her substitute or substitutes, may do or cause to be done
by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed by the following persons in the capacities and on the
dates indicated.
Signatures
Title
Date
/S/  LOUIS G. LANGE
Louis G. Lange, M.D., Ph.D.
Chairman of the Board and
Chief Executive Officer
(Principal executive officer)
October 2, 2002
/S/  DANIEL K. SPIEGELMAN
Daniel K. Spiegelman
Chief Financial Officer
(Principal
financial and
accounting officer)
October 2, 2002
/S/  SANTO J. COSTA
Santo J. Costa
Director
October 2, 2002
/S/  R. SCOTT GREER
R. Scott Greer
Director
October 2, 2002
/S/  JOHN GROOM
John Groom
Director
October 2, 2002
/S/  THOMAS L. GUTSHALL
Thomas L. Gutshall
Director
October 2, 2002
3
Table of Contents
Signatures
Title
Date
/S/  PETER BARTON HUTT
Peter Barton Hutt
Director
October 2, 2002
/S/  KENNETH B. LEE, JR.
Kenneth B. Lee, Jr.
Director
October 2, 2002
/S/  BARBARA J. MCNEIL
Barbara J. McNeil, M.D., Ph.D.
Director
October 2, 2002
/S/  COSTA G. SEVASTOPOULOS
Costa G. Sevastopoulos, Ph.D.
Director
October 2, 2002
4
Table of Contents
INDEX TO EXHIBITS
EXHIBIT
DESCRIPTION
4.1
CV Therapeutics, Inc. 2000 Nonstatutory Incentive Plan, as amended.
5.1
Opinion of Latham & Watkins.
23.1
Consent of Latham & Watkins (included in Exhibit 5.1 hereto)
23.2
Consent of Ernst & Young LLP, Independent Auditors.
24.1
Power of Attorney (included on the signature page to this
Registration Statement)
5