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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<P align="right"><FONT size="2">As filed with the Securities and Exchange Commission on February&nbsp;18, 2003<BR>
Registration No.&nbsp;333-</FONT>

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<P align="center"><FONT size="4"><B>SECURITIES AND EXCHANGE COMMISSION</B></FONT>

<DIV align="center"><FONT size="3"><B>Washington, D.C. 20549</B>
</FONT></DIV>
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<P align="center"><FONT size="5"><B>FORM S-8</B>
</FONT>
<P align="center"><FONT size="3"><B>REGISTRATION STATEMENT</B>
</FONT>

<DIV align="center"><FONT size="3"><B><I>Under<BR>
The Securities Act of 1933</I></B>
</FONT>
</DIV>
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<P align="center"><FONT size="6"><B>ISTA PHARMACEUTICALS, INC.</B></FONT>

<DIV align="center"><FONT size="2"><B>(Exact name of Registrant as specified in its charter)</B>
</FONT>
</DIV>
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    <TD width="30%">&nbsp;</TD>
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    <TD align="center" valign="top"><FONT size="2"><B>Delaware<BR>
(State or other jurisdiction of<BR>
incorporation or organization)</B></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
<B>ISTA Pharmaceuticals, Inc.<BR>
15279 Alton Parkway, Building 100<BR>
Irvine, CA 92618<BR>
(949)&nbsp;788-6000</B>
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2"><B>75-0511729<BR>
(I.R.S. Employer<BR>
Identification Number)</B></FONT></TD>
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<DIV align="center"><FONT size="2"><B>(Address, including zip code,
and telephone number, including area code, of Registrant&#146;s
principal executive offices)</B>
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</FONT></DIV>
<P align="center"><FONT size="2"><B>2000 EMPLOYEE STOCK PURCHASE
PLAN</B></FONT>

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<P align="center"><FONT size="2"><B>Vicente Anido, Jr., Ph.D.<BR>
President and Chief Executive Officer<BR>
ISTA Pharmaceuticals, Inc.<BR>
15279 Alton Parkway, Building 100<BR>
Irvine, CA 92618<BR>
(949)&nbsp;788-6000</B></FONT>

<DIV align="center"><FONT size="2"><B>(Name, address, including zip
code, and telephone number, including area code, of agent for
service)</B>
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</FONT></DIV>
<P align="center"><FONT size="2"><I>Copy to:</I><BR>
<B>Robert C. Funsten<BR>
Stradling Yocca Carlson &#038; Rauth<BR>
a Professional Corporation<BR>
660 Newport Center Drive, Suite&nbsp;1600<BR>
Newport Beach, CA 92660<BR>
(949)&nbsp;725-4000</B></FONT>

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<P align="center"><FONT size="2">CALCULATION OF REGISTRATION FEE
</FONT>
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    <TD width="12%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
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    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
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    <TD width="1%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
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    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
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    <TD nowrap align="center" colspan="2"><FONT size="1"><B>Title of Securities to</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount to be</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration</B></FONT></TD>
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    <TD nowrap align="center" colspan="2"><FONT size="1"><B>be Registered</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registered</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Per Share</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Fee</B></FONT></TD>
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    <TD><FONT size="1">&nbsp;</FONT></TD>
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    <TD><FONT size="1">&nbsp;</FONT></TD>
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    <TD colspan="2"><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock</FONT></DIV></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">$0.001 par value</FONT></DIV></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD colspan="3" align="center"><FONT size="2">40,000 shares (1)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">5.09</FONT></TD>
    <TD nowrap><FONT size="2">(2)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">203,600</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">18.73</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Represents additional shares authorized to be issued under the 2000
Employee Stock Purchase Plan.</FONT></TD>
</TR>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Estimated in accordance with Rule&nbsp;457(h)(1) under the Securities Act of
1933, as amended, solely for the purpose of calculating the registration fee.</FONT></TD>
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<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD colspan="9"><A HREF="#000">PART II INFORMATION REQUIRED IN REGISTRATION STATEMENT</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">ITEM 8. EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="#002">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">POWER OF ATTORNEY</A></TD></TR>
<TR><TD colspan="9"><A HREF="#004">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="a87806exv5w1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a87806exv10w2.txt">EXHIBIT 10.2</A></TD></TR>
<TR><TD colspan="9"><A HREF="a87806exv23w1.txt">EXHIBIT 23.1</A></TD></TR>
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<P align="center"><FONT size="2">EXPLANATORY NOTE</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement has been prepared in accordance with General
Instruction E to Form&nbsp;S-8, as amended, and relates to an increase of 40,000
shares of common stock, $0.001 par value per share, of the Company, reserved
for issuance under the Company&#146;s 2000 Employee Stock Purchase Plan, authorized
pursuant to &#147;evergreen&#148; clause increases for the 2001 and 2002 fiscal years.
399,293 shares of the Company&#146;s common stock have previously been registered
for issuance under the 2000 Employee Stock Purchase Plan pursuant to
Registration Statement on Form&nbsp;S-8 filed February&nbsp;22, 2001 (File No.
333-56042).
</FONT>
<P align="center"><FONT size="2">2</FONT>
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<DIV align="left"><A NAME="000"></A></DIV>
<P align="center"><FONT size="2">PART II<BR>
INFORMATION REQUIRED IN REGISTRATION STATEMENT</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The contents of the Company&#146;s previously filed Registration Statement on
Form&nbsp;S-8 (File No.&nbsp;333-56042) relating to shares issued under the Company&#146;s
2000 Employee Stock Purchase Plan are hereby incorporated by reference.
</FONT>
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<DIV align="left"><A NAME="001"></A></DIV>
<P align="left"><FONT size="2">ITEM 8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EXHIBITS.</FONT>


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    <TD nowrap align="center"><FONT size="1"><B>Exhibit</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
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    <TD nowrap align="center"><FONT size="1"><B>Number</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Description of Document</B></FONT></TD>
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    <TD  align="center" valign="top"><FONT size="2">&nbsp;&nbsp;5.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion re legality of Stradling Yocca Carlson &#038; Rauth, a Professional Corporation.</FONT></TD>
</TR>

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    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

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    <TD  align="center" valign="top"><FONT size="2">10.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
2000 Employee Stock Purchase Plan.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD  align="center" valign="top"><FONT size="2">23.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Independent Auditors.</FONT></TD>
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    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
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    <TD  align="center" valign="top"><FONT size="2">23.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Counsel (contained in Exhibit&nbsp;5.1).</FONT></TD>
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    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
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<TR>
    <TD align="center" valign="top"><FONT size="2">24.1
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Power of Attorney (see page S-2).</FONT></TD>
</TR>

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<P align="center"><FONT size="2">3</FONT>
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<DIV align="left"><A NAME="002"></A></DIV>
<P align="center"><FONT size="2">SIGNATURES</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form&nbsp;S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Irvine, State of California, on February&nbsp;14,
2003.
</FONT>
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    <TD width="30%">&nbsp;</TD>
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    <TD width="8%">&nbsp;</TD>
    <TD valign="bottom"><FONT size="2">By:</FONT></TD>
    <TD valign="bottom"><FONT size="2">/s/</FONT></TD>
    <TD align="left" valign="bottom"><FONT size="2">
Vicente Anido, Jr.</FONT></TD>
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    <TD width="8%">&nbsp;</TD>
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
 <TD colspan="3" valign="middle"><FONT size="2">   <HR size="1" noshade></FONT>
</TD>

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    <TD width="8%">&nbsp;</TD>
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD colspan="2" align="left" valign="top"><FONT size="2">
&nbsp;&nbsp;&nbsp;&nbsp;Vicente Anido, Jr., Ph.D.<BR>
&nbsp;&nbsp;&nbsp;&nbsp;President and Chief Executive Officer</FONT></TD>
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<P align="center"><FONT size="2">S-1</FONT>
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<DIV align="left"><A NAME="003"></A></DIV>
<P align="center"><FONT size="2">POWER OF ATTORNEY</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Vicente
Anido, Jr., Ph.D., and David R. Waltz and each them as his attorneys-in-fact,
with full power of substitution, for him in any and all capacities, to sign any
amendments to this Registration Statement on Form&nbsp;S-8, and to file the same,
with all exhibits thereto and other documents in connection therewith, with the
Securities and Exchange Commission, hereby ratifying and confirming all that
said attorney-in-fact, or his substitute, may do or cause to be done by virtue
hereof.
</FONT>
<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement on Form&nbsp;S-8 has been signed by the following
persons in the capacities and on the dates indicated.
</FONT>
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    <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
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    <TD><FONT size="1">&nbsp;</FONT></TD>
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    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
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<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Vicente Anido, Jr.<BR>

<HR Size="1" noshade>

Vicente Anido, Jr., Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
President, Chief Executive<BR>
Officer and Director (Principal<BR>
Executive Officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">February 14, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ David R. Waltz<BR>
<HR size="1" noshade>
David R. Waltz</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Vice President Finance<BR>
(Principal Financial and<BR>
Accounting Officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">February 14, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2"><HR size="1" noshade>
Robert G. McNeil, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Chairman of the Board of Directors
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">February &nbsp;&nbsp;, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Liza Page Nelson<BR>
<HR size="1" noshade>
Liza Page Nelson</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">February 14, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Peter Barton Hutt<BR>
<HR size="1" noshade>
Peter Barton Hutt</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">February 14, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2"><HR size="1" noshade>
Kathleen D. LaPorte</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">February &nbsp;&nbsp;, 2003</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Benjamin F. McGraw III<HR size="1" noshade>
Benjamin F. McGraw III</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">February 14, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Richard C. Williams<BR>
<HR size="1" noshade>
Richard C. Williams</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">February 14, 2003</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Wayne I. Roe<HR size="1" noshade>
Wayne I. Roe</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">February 14, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Jeffrey L. Edwards<BR>
<HR size="1" noshade>
Jeffrey L. Edwards</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">February 14, 2003</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">S-2</FONT>
<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "EXHIBIT INDEX" -->
<DIV align="left"><A NAME="004"></A></DIV>
<P align="center"><FONT size="2">EXHIBIT INDEX</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="65%">
<TR valign="bottom">
    <TD width="11%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="84%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Exhibit</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Number</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Description of Document</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="Center"><FONT size="2"> &nbsp;&nbsp;5.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion re legality of Stradling Yocca Carlson &#038; Rauth, a
Professional Corporation.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="Center"><FONT size="2">10.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
2000 Employee Stock Purchase Plan.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="center"><FONT size="2">23.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Independent Auditors.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="Center"><FONT size="2">23.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Counsel (contained in Exhibit&nbsp;5.1).</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top" align="Center"><FONT size="2">24.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Power of Attorney (see page S-2).</FONT></TD>
</TR>
</TABLE>
</CENTER>






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</HTML>
[{"type": "S-8", "sequence": "1", "filename": "a87806sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 26217}]
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ISTA Pharmaceuticals Inc
Table of Contents
As filed with the Securities and Exchange Commission on February 18, 2003
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
ISTA PHARMACEUTICALS, INC.
(Exact name of Registrant as specified in its charter)
Delaware
(State or other jurisdiction of
incorporation or organization)
ISTA Pharmaceuticals, Inc.
15279 Alton Parkway, Building 100
Irvine, CA 92618
(949) 788-6000
75-0511729
(I.R.S. Employer
Identification Number)
(Address, including zip code,
and telephone number, including area code, of Registrant's
principal executive offices)
2000 EMPLOYEE STOCK PURCHASE
PLAN
Vicente Anido, Jr., Ph.D.
President and Chief Executive Officer
ISTA Pharmaceuticals, Inc.
15279 Alton Parkway, Building 100
Irvine, CA 92618
(949) 788-6000
(Name, address, including zip
code, and telephone number, including area code, of agent for
service)
Copy to:
Robert C. Funsten
Stradling Yocca Carlson & Rauth
a Professional Corporation
660 Newport Center Drive, Suite 1600
Newport Beach, CA 92660
(949) 725-4000
CALCULATION OF REGISTRATION FEE
Proposed Maximum
Proposed Maximum
Amount of
Title of Securities to
Amount to be
Offering Price
Aggregate
Registration
be Registered
Registered
Per Share
Offering Price
Fee
Common Stock
$0.001 par value
40,000 shares (1)
$
5.09
(2)
$
203,600
$
18.73
(1)
Represents additional shares authorized to be issued under the 2000
Employee Stock Purchase Plan.
(2)
Estimated in accordance with Rule 457(h)(1) under the Securities Act of
1933, as amended, solely for the purpose of calculating the registration fee.
TABLE OF CONTENTS
PART II INFORMATION REQUIRED IN REGISTRATION STATEMENT
ITEM 8. EXHIBITS
SIGNATURES
POWER OF ATTORNEY
EXHIBIT INDEX
EXHIBIT 5.1
EXHIBIT 10.2
EXHIBIT 23.1
Table of Contents
EXPLANATORY NOTE
This Registration Statement has been prepared in accordance with General
Instruction E to Form S-8, as amended, and relates to an increase of 40,000
shares of common stock, $0.001 par value per share, of the Company, reserved
for issuance under the Company's 2000 Employee Stock Purchase Plan, authorized
pursuant to "evergreen" clause increases for the 2001 and 2002 fiscal years.
399,293 shares of the Company's common stock have previously been registered
for issuance under the 2000 Employee Stock Purchase Plan pursuant to
Registration Statement on Form S-8 filed February 22, 2001 (File No.
333-56042).
2
Table of Contents
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
The contents of the Company's previously filed Registration Statement on
Form S-8 (File No. 333-56042) relating to shares issued under the Company's
2000 Employee Stock Purchase Plan are hereby incorporated by reference.
ITEM 8.             EXHIBITS.
Exhibit
Number
Description of Document
5.1
Opinion re legality of Stradling Yocca Carlson & Rauth, a Professional Corporation.
10.2
2000 Employee Stock Purchase Plan.
23.1
Consent of Independent Auditors.
23.2
Consent of Counsel (contained in Exhibit 5.1).
24.1
Power of Attorney (see page S-2).
3
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Irvine, State of California, on February 14,
2003.
By:
/s/
Vicente Anido, Jr.
Vicente Anido, Jr., Ph.D.
President and Chief Executive Officer
S-1
Table of Contents
POWER OF ATTORNEY
Each person whose signature appears below constitutes and appoints Vicente
Anido, Jr., Ph.D., and David R. Waltz and each them as his attorneys-in-fact,
with full power of substitution, for him in any and all capacities, to sign any
amendments to this Registration Statement on Form S-8, and to file the same,
with all exhibits thereto and other documents in connection therewith, with the
Securities and Exchange Commission, hereby ratifying and confirming all that
said attorney-in-fact, or his substitute, may do or cause to be done by virtue
hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement on Form S-8 has been signed by the following
persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Vicente Anido, Jr.
Vicente Anido, Jr., Ph.D.
President, Chief Executive
Officer and Director (Principal
Executive Officer)
February 14, 2003
/s/ David R. Waltz
David R. Waltz
Vice President Finance
(Principal Financial and
Accounting Officer)
February 14, 2003
Robert G. McNeil, Ph.D.
Chairman of the Board of Directors
February   , 2003
/s/ Liza Page Nelson
Liza Page Nelson
Director
February 14, 2003
/s/ Peter Barton Hutt
Peter Barton Hutt
Director
February 14, 2003
Kathleen D. LaPorte
Director
February   , 2003
/s/ Benjamin F. McGraw III
Benjamin F. McGraw III
Director
February 14, 2003
/s/ Richard C. Williams
Richard C. Williams
Director
February 14, 2003
/s/ Wayne I. Roe
Wayne I. Roe
Director
February 14, 2003
/s/ Jeffrey L. Edwards
Jeffrey L. Edwards
Director
February 14, 2003
S-2
Table of Contents
EXHIBIT INDEX
Exhibit
Number
Description of Document
5.1
Opinion re legality of Stradling Yocca Carlson & Rauth, a
Professional Corporation.
10.2
2000 Employee Stock Purchase Plan.
23.1
Consent of Independent Auditors.
23.2
Consent of Counsel (contained in Exhibit 5.1).
24.1
Power of Attorney (see page S-2).