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<TITLE>St. Jude Medical, Inc. Form S-8 dated December 7, 2005 </TITLE>
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<P ALIGN=RIGHT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Registration No. 333-______ </FONT></P>

<DIV ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>As filed with the Securities and Exchange Commission on December 7, 2005 </FONT></DIV>


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<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=4><B>UNITED STATES
<BR>SECURITIES AND EXCHANGE COMMISSION </B></FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Washington, D.C. 20549 </FONT></P>


<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="6"><B>FORM S-8</B> </FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE=3><B>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 </B></FONT> </P>

<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="6"><B>ST. JUDE MEDICAL, INC.</B> </FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(Exact name of registrant as specified in its charter) </FONT> </P>

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     <TD WIDTH=45% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="3"><B>Minnesota</B> </FONT></TD>
     <TD WIDTH=8% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>&nbsp;</B> </FONT></TD>
     <TD WIDTH=45% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="3"><B>41-1276891</B> </FONT></TD>
     <TD WIDTH=2% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;</FONT></TD></TR>
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     <TD ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(State or other jurisdiction</FONT></TD><TD ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;</FONT></TD>
     <TD ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(I.R.S. Employer</FONT></TD><TD ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;</FONT></TD></TR>
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     <TD ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>of incorporation or organization)</FONT></TD><TD ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;</FONT></TD>
     <TD ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Identification No.)</FONT></TD><TD ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;</FONT></TD></TR>
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<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=3><B>One Lillehei Plaza
<BR>St. Paul, Minnesota 55117 </B></FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(Address of principal executive offices,
<BR>including zip code) </FONT></P>


<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=3><B>QUEST MEDICAL, INC. 1995 STOCK OPTION PLAN
<BR>QUEST MEDICAL, INC. 1998 STOCK OPTION PLAN
<BR>ADVANCED NEUROMODULATION SYSTEMS, INC. 2000 STOCK OPTION PLAN
<BR>ADVANCED NEUROMODULATION SYSTEMS, INC. 2001 EMPLOYEE STOCK OPTION PLAN
<BR>ADVANCED NEUROMODULATION SYSTEMS, INC. 2002 STOCK OPTION PLAN
<BR>ADVANCED NEUROMODULATION SYSTEMS, INC. 2004 STOCK INCENTIVE PLAN </B></FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(Full title of the plans) </FONT></P>

<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=3><B>Kevin T. O&#146;Malley
<BR>Vice President and General Counsel
<BR>St. Jude Medical, Inc.
<BR>One Lillehei Plaza
<BR>St. Paul, Minnesota 55117
<BR>(651) 483-2000 </B></FONT>
<BR><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(Name, address and telephone number,
<BR>including area code, of agent for service) </FONT></P>


<H1 style="margin-bottom:6pt;" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>CALCULATION OF REGISTRATION FEE </FONT></H1>

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     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Title of securities to be registered</FONT></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Amount to be<BR>registered(1)</FONT></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Proposed maximum<BR>offering price per<BR>share(2)</FONT></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Proposed maximum<BR>aggregate offering<BR>price(2)</FONT></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Amount of<BR>registration fee</FONT></TH></TR>
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     <TD WIDTH=20% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;Common Stock,<BR>&nbsp;&nbsp;&nbsp;par value $0.10 per share(3)</FONT></TD>
     <TD WIDTH=20% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>1,000,483 Shares</FONT></TD>
     <TD WIDTH=20% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>$48.62</FONT></TD>
     <TD WIDTH=20% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>$48,643,484</FONT></TD>
     <TD WIDTH=20% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>$5,205</FONT></TD></TR>
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<TD ALIGN=LEFT WIDTH=3%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(1) </FONT></TD>
<TD WIDTH=97%><P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The number of shares being registered represents the
number of shares of common stock of St. Jude Medical, Inc. issuable under each of the following plans: Quest Medical, Inc. 1995
Stock Option Plan (146,771 shares); Quest Medical, Inc. 1998 Stock Option Plan (113,197 shares); Advanced Neuromodulation Systems,
Inc. 2000 Stock Option Plan (54,753 shares); Advanced Neuromodulation Systems, Inc. 2001 Employee Stock Option Plan (158,691
shares); Advanced Neuromodulation Systems, Inc. 2002 Stock Option Plan (235,468 shares); and Advanced Neuromodulation Systems,
Inc. 2004 Stock Incentive Plan (291,603 shares). Pursuant to Rule 416 under the Securities Act of 1933, as amended, this
registration statement shall also cover any additional shares of common stock which become issuable under such plans pursuant to
their respective antidilution provisions. </FONT></P></TD>
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<TD ALIGN=LEFT WIDTH=3%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(2) </FONT></TD>
<TD WIDTH=97%><P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Estimated solely for the purpose of calculating the
registration fee in accordance with Rule 457(h)(1) and (c) under the Securities Act of 1933, as amended. The proposed maximum
offering price is based on the average of the high and low prices of St. Jude Medical, Inc. common stock as reported on the New
York Stock Exchange on December 2, 2005. </FONT></P></TD>
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<TD ALIGN=LEFT WIDTH=3%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(3)  </FONT></TD>
<TD WIDTH=97%><P ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Includes corresponding rights to acquire shares of
St. Jude Medical, Inc. preferred stock pursuant to the Rights Agreement, dated as of June 16, 1997 and amended as of December 20,
2002, between St. Jude Medical, Inc. and American Stock Transfer and Trust Company. </FONT></P></TD>
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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=3>PART II </FONT></H1>
<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=3>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT </FONT></H1>

<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=3>Item 3.&nbsp;&nbsp;&nbsp;&nbsp;Incorporation of Documents by Reference. </FONT></H1>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents,
which have been filed with the Securities and Exchange Commission (the &#147;SEC&#148;) by St. Jude Medical, Inc. (&#147;we,&#148;
&#147;us&#148; or &#147;St. Jude&#148;), are incorporated by reference in this registration statement: </FONT></P>

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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(a)  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Our Annual Report on Form 10-K for the year ended December 31,
2004; </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(b)  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Our Quarterly Reports on Form 10-Q for the quarters ended March
31, 2005, June 30, 2005 and September 30, 2005; </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(c)  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Our Current Reports on Form 8-K filed on January 14, 2005,
February 15, 2005, March 2, 2005, March 4, 2005, April 7, 2005, April 25, 2005, May 12, 2005, August 8, 2005, October 7, 2005,
October 12, 2005, October 17, 2005 (except as to Item 7.01 thereof), October 25, 2005 and November 21, 2005 (as amended by our
Current Report on Form 8-K/A filed on December 5, 2005); and </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(d)  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>The description of our common stock and preferred stock purchase
rights contained in any registration statement or report filed by us under the Securities Exchange Act of 1934, as amended (the
&#147;Exchange Act&#148;), including any amendment or report filed for the purpose of updating such description. </FONT></TD>
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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents filed by us
pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the date hereof and prior to the filing of
a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities
remaining unsold shall be deemed to be incorporated by reference herein and to be a part hereof from the respective dates of
filing of such documents. </FONT></P>

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<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=3>Item 4.&nbsp;&nbsp;&nbsp;&nbsp;Description of Securities. </FONT></H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>

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<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=3>Item 5.&nbsp;&nbsp;&nbsp;&nbsp;Interests of Named Experts and Counsel. </FONT></H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>

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<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=3>Item 6.&nbsp;&nbsp;&nbsp;&nbsp;Indemnification of Directors and Officers. </FONT></H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;521 of the
Minnesota Business Corporation Act provides that a company shall, subject to certain limitations, indemnify officers and directors
made or threatened to be made a party to a proceeding by reason of that officer or director&#146;s former or present official
capacity with the company. As required, we will indemnify that person against judgments, penalties, fines, settlements and
reasonable expenses if the officer or director: </FONT></P>

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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&#149;  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>has not been indemnified by another organization; </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&#149;  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>acted in good faith; </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&#149;  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>has not received an improper personal benefit and Section 255
regarding director conflicts of interests, if applicable, has been satisfied; </FONT></TD>
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<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>II-1 </FONT></P>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&#149;  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>assuming the case is a criminal proceeding, the person had no
reasonable cause to believe the conduct was unlawful; and </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&#149;  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>reasonably believed that the conduct was in the best interests of
the company or, in the case of an officer or director who is or was serving at the request of the company as a director, officer,
partner, trustee, employee or agent of another organization or employee benefit plan, reasonably believed that the conduct was not
opposed to the best interests of the company. </FONT></TD>
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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Article XIV of our Articles
of Incorporation, as amended and restated, provides that, to the fullest extent permissible under the Minnesota Business
Corporation Act, our directors shall not be liable to St. Jude or our shareholders for monetary damages for breach of fiduciary
duty as a director. </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Article
VII of our Bylaws, as amended and restated, provides that we shall indemnify our officers
and directors under such circumstances and to the extent permitted by Section 521 of the
Minnesota Business Corporation Act described above. </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We enter into indemnification
agreements with our directors and officers. The indemnification agreements provide that we shall, subject to certain limitations,
indemnify our directors and officers who are made or threatened to be made a party to a proceeding by reason of that
director&#146;s or officer&#146;s former or present official capacity with St. Jude Medical. The circumstances under which we will
indemnify our directors or officers against judgments, penalties, fines, settlements and reasonable expenses pursuant to these
indemnification agreements are the same as those provided in Section 521 of the Minnesota Business Corporation Act described
above. </FONT></P>

<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We maintain directors&#146;
and officers&#146; liability insurance which covers certain liabilities and expenses of our directors and officers and covers St.
Jude for reimbursement of payments to our directors and officers in respect of such liabilities and expenses. </FONT></P>

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<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=3>Item 7.&nbsp;&nbsp;&nbsp;&nbsp;Exemption from Registration Claimed. </FONT></H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable. </FONT></P>

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<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>II-2 </FONT></P>
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<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=3>Item 8.&nbsp;&nbsp;&nbsp;&nbsp;Exhibits. </FONT></H1>

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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>4.1 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Articles of Incorporation, as restated as of February 25, 2005
(incorporated by reference from Exhibit 3.1 of the Company&#146;s Annual Report on Form 10-K for the year ended December 31,
2004). </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>4.2 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Bylaws, as amended and restated as of February 25, 2005
(incorporated by reference from Exhibit 3.1 of the Company&#146;s Current Report on Form 8-K dated March 2, 2005). </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>4.3 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Rights Agreement dated as of June 16, 1997, between the Company
and American Stock Transfer and Trust Company, as Rights Agent, including the Certificate of Designation, Preferences and Rights
of Series B Junior Preferred Stock (incorporated by reference from Exhibit 4 of the Company&#146;s Quarterly Report on Form 10-Q
for the quarter ended June 30, 1997). </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>4.4 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Amendment, dated as of December 20, 2002, to Rights Agreement,
dated as of June 16, 1997 (incorporated by reference from Exhibit 1 of the Company&#146;s Current Report on Form 8-K filed on
March 21, 2003). </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>5.1  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Opinion of Dorsey &amp; Whitney LLP. </FONT></TD>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>    23.1  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Consent of Dorsey &amp; Whitney LLP (included in Exhibit 5.1). </FONT></TD>
</TR>
</TABLE>
<BR>

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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>23.2  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Consent of Ernst &amp; Young LLP. </FONT></TD>
</TR>
</TABLE>
<BR>

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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>23.3  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Consent of Ernst &amp; Young LLP. </FONT></TD>
</TR>
</TABLE>
<BR>


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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>24.1  </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Power of Attorney. </FONT></TD>
</TR>
</TABLE>
<BR>

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<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=3>Item 9.&nbsp;&nbsp;&nbsp;&nbsp;Undertakings. </FONT></H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The undersigned registrant hereby undertakes:  </FONT></P>

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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=95%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
</FONT>
</TD>
</TR>
</TABLE>
<BR>

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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act of 1933, as amended (the &#147;Securities
Act&#148;); </FONT>
</TD>
</TR>
</TABLE>
<BR>

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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set
forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if
the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high
end of the estimated maximum offering range may be reflected in the form of prospectus filed with the SEC pursuant to
Rule&nbsp;424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum
aggregate offering price set forth in the &#147;Calculation of Registration Fee&#148; table in the effective registration
statement; and </FONT>
</TD>
</TR>
</TABLE>
<BR>

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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;               To
include any material information with respect to the plan of distribution not
               previously disclosed in the registration statement or any material change
to                such information in the registration statement;  </FONT>
</TD>
</TR>
</TABLE>
<BR>

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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
<I>provided</I>,
<I>however,</I> that paragraphs&nbsp;(a)(1)(i) and (a)(1)(ii) above do not apply if the
information required to be included in a post-effective amendment by those paragraphs is
contained in periodic reports filed with or furnished to the SEC by the registrant
pursuant to Section&nbsp;13 or Section&nbsp;15(d) of the Exchange Act that are
incorporated by reference in the registration statement.  </FONT></TD>
</TR>
</TABLE>
<BR>


<BR><BR>
<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>II-3 </FONT></P>
<HR SIZE=3 COLOR=GRAY NOSHADE>
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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=95%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;That,
for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a
new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof. </FONT>
</TD>
</TR>
</TABLE>
<BR>

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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=95%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
termination of the offering. </FONT>
</TD>
</TR>
</TABLE>
<BR>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of
the registrant&#146;s annual report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of the Exchange Act that is incorporated
by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
</FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar
as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion
of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In
the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the
registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue. </FONT></P>


<BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR>
<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>II-4 </FONT></P>
<HR SIZE=3 COLOR=GRAY NOSHADE>
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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>SIGNATURES </FONT></H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements
of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of St.&nbsp;Paul, State of Minnesota, on December 7, 2005. </FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="90%">
<TR><TD colspan="2"></TD>
<TD COLSPAN=2><FONT FACE="Times New Roman, Times, Serif" SIZE=2>ST. JUDE MEDICAL, INC.</FONT></TD></TR>
<TR><TD colspan="4">&nbsp;</TD></TR>
<TR VALIGN=TOP><TD WIDTH="5%"><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
<TD WIDTH=54%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><!-- Insert date -->
</FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>By:&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD WIDTH=45% style="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>/s/&nbsp;Daniel J. Starks
</FONT></TD></TR>
<TR><TD colspan="3"></TD><TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Daniel J. Starks</FONT></TD></TR>
<TR><TD colspan="3">&nbsp;</TD><TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>President, Chief Executive Officer and Chairman</FONT></TD></TR>
</TABLE>
<BR>


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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements
of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities
indicated on December&nbsp;7, 2005. </FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="90%">
<TR VALIGN="BOTTOM">
     <TH ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Signature</FONT></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TH>
     <TH ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Title</FONT></TH></TR>
<TR><TD>&nbsp;</TD></TR>

<TR VALIGN="TOP">
     <TD STYLE="border-bottom: 1px solid black" WIDTH="40%"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">/s/ Daniel J. Starks</FONT></TD>
     <TD WIDTH="10%"><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD WIDTH="40%"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">President, Chief Executive Officer and Chairman</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Daniel J. Starks</FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">(principal executive officer)</FONT></TD></TR>
<TR><TD>&nbsp;</TD></TR>

<TR VALIGN="TOP">
     <TD STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">/s/ John C. Heinmiller</FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Executive Vice President and Chief Financial Officer</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">John C. Heinmiller</FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">(principal financial and accounting officer)</FONT></TD></TR>

<TR><TD>&nbsp;</TD></TR>
<TR VALIGN="TOP">
     <TD align=center STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">*  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Director</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">John W. Brown  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD></TR>

<TR><TD>&nbsp;</TD></TR>
<TR VALIGN="TOP">
     <TD align=center STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">*  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Director</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Richard R. Devenuti</FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD></TR>

<TR><TD>&nbsp;</TD></TR>
<TR VALIGN="TOP">
     <TD align=center STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">*  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Director</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Stuart M. Essig</FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD></TR>

<TR><TD>&nbsp;</TD></TR>
<TR VALIGN="TOP">
     <TD align=center STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">*  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Director</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Thomas H. Garrett III</FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD></TR>

<TR><TD>&nbsp;</TD></TR>
<TR VALIGN="TOP">
     <TD align=center STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">*  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Director</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Michael A. Rocca</FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD></TR>

<TR><TD>&nbsp;</TD></TR>
<TR VALIGN="TOP">
     <TD align=center STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">*  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Director</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">David A. Thompson </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD></TR>

<TR><TD>&nbsp;</TD></TR>
<TR VALIGN="TOP">
     <TD align=center STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">*  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Director</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Stefan K. Widensohler</FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD></TR>

<TR><TD>&nbsp;</TD></TR>
<TR VALIGN="TOP">
     <TD align=center STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">*  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Director</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Wendy L. Yarno  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD></TR>

<TR><TD>&nbsp;</TD></TR>
<TR VALIGN="TOP">
     <TD align=center STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">*  </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Director</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Frank C-P Yin </FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD></TR>
</TABLE>
<BR>


<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="40%">
<TR VALIGN="TOP">
     <TD WIDTH="5%"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">*By:</FONT></TD>
     <TD WIDTH="5%"><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD STYLE="border-bottom: 1px solid black"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">/s/ Kevin T. O&#146;Malley</FONT></TD></TR>
<TR VALIGN="TOP">
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Kevin T. O&#146;Malley<BR>Attorney-in-Fact</FONT></TD></TR>
</TABLE>
<BR>



<BR><BR>
<P ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>II-5 </FONT></P>
<HR SIZE=3 COLOR=GRAY NOSHADE>
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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=3>EXHIBIT INDEX </FONT></H1>

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<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=BOTTOM>
<TD align=center WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>Exhibit<BR><U>Number</U></B> </FONT> </TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH="90%" ALIGN="CENTER">
<FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U><B>Description</B></U> </FONT> </TD>
</TR>
</TABLE>
<BR>


<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD align=center WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2> &nbsp;&nbsp;4.1 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Articles of Incorporation, as restated as of February 25, 2005
(incorporated by reference from Exhibit 3.1 of the Company&#146;s Annual Report on Form 10-K for the year ended December 31, 2004).
</FONT></TD>
</TR>
</TABLE>
<BR>

<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD align=center WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2> &nbsp;&nbsp;4.2 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Bylaws, as amended and restated as of February 25, 2005
(incorporated by reference from Exhibit 3.1 of the Company&#146;s Current Report on Form 8-K dated March 2, 2005). </FONT></TD>
</TR>
</TABLE>
<BR>

<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD align=center WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2> &nbsp;&nbsp;4.3 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Rights Agreement dated as of June 16, 1997, between the Company
and American Stock Transfer and Trust Company, as Rights Agent, including the Certificate of Designation, Preferences and Rights
of Series B Junior Preferred Stock (incorporated by reference from Exhibit 4 of the Company&#146;s Quarterly Report on Form 10-Q for
the quarter ended June 30, 1997). </FONT></TD>
</TR>
</TABLE>
<BR>

<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD align=center WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2> &nbsp;&nbsp;4.4 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Amendment, dated as of December 20, 2002, to Rights Agreement,
dated as of June 16, 1997 (incorporated by reference from Exhibit 1 of the Company&#146;s Current Report on Form 8-K filed on March 21,
2003). </FONT></TD>
</TR>
</TABLE>
<BR>

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<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Opinion of Dorsey &amp; Whitney LLP. </FONT></TD>
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<TD align=center WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2> 23.1 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Consent of Dorsey &amp; Whitney LLP (included in Exhibit 5.1).
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<TD align=center WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2> 23.2 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Consent of Ernst &amp; Young LLP. </FONT></TD>
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<TD align=center WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2> 23.3 </FONT></TD>
<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Consent of Ernst &amp; Young LLP. </FONT></TD>
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<TD><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=90%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Power of Attorney. </FONT></TD>
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[{"type": "S-8", "sequence": "1", "filename": "stjude055039_s8.htm", "description": "REGISTRATION STATEMENT DATED DECEMBER 7, 2005", "secsgml_size_bytes": 48327}]
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St. Jude Medical, Inc. Form S-8 dated December 7, 2005
Registration No. 333-______
As filed with the Securities and Exchange Commission on December 7, 2005
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
ST. JUDE MEDICAL, INC.
(Exact name of registrant as specified in its charter)
Minnesota
41-1276891
(State or other jurisdiction
(I.R.S. Employer
of incorporation or organization)
Identification No.)
One Lillehei Plaza
St. Paul, Minnesota 55117
(Address of principal executive offices,
including zip code)
QUEST MEDICAL, INC. 1995 STOCK OPTION PLAN
QUEST MEDICAL, INC. 1998 STOCK OPTION PLAN
ADVANCED NEUROMODULATION SYSTEMS, INC. 2000 STOCK OPTION PLAN
ADVANCED NEUROMODULATION SYSTEMS, INC. 2001 EMPLOYEE STOCK OPTION PLAN
ADVANCED NEUROMODULATION SYSTEMS, INC. 2002 STOCK OPTION PLAN
ADVANCED NEUROMODULATION SYSTEMS, INC. 2004 STOCK INCENTIVE PLAN
(Full title of the plans)
Kevin T. O'Malley
Vice President and General Counsel
St. Jude Medical, Inc.
One Lillehei Plaza
St. Paul, Minnesota 55117
(651) 483-2000
(Name, address and telephone number,
including area code, of agent for service)
CALCULATION OF REGISTRATION FEE
Title of securities to be registered
Amount to be
registered(1)
Proposed maximum
offering price per
share(2)
Proposed maximum
aggregate offering
price(2)
Amount of
registration fee
Common Stock,
par value $0.10 per share(3)
1,000,483 Shares
$48.62
$48,643,484
$5,205
(1)
The number of shares being registered represents the
number of shares of common stock of St. Jude Medical, Inc. issuable under each of the following plans: Quest Medical, Inc. 1995
Stock Option Plan (146,771 shares); Quest Medical, Inc. 1998 Stock Option Plan (113,197 shares); Advanced Neuromodulation Systems,
Inc. 2000 Stock Option Plan (54,753 shares); Advanced Neuromodulation Systems, Inc. 2001 Employee Stock Option Plan (158,691
shares); Advanced Neuromodulation Systems, Inc. 2002 Stock Option Plan (235,468 shares); and Advanced Neuromodulation Systems,
Inc. 2004 Stock Incentive Plan (291,603 shares). Pursuant to Rule 416 under the Securities Act of 1933, as amended, this
registration statement shall also cover any additional shares of common stock which become issuable under such plans pursuant to
their respective antidilution provisions.
(2)
Estimated solely for the purpose of calculating the
registration fee in accordance with Rule 457(h)(1) and (c) under the Securities Act of 1933, as amended. The proposed maximum
offering price is based on the average of the high and low prices of St. Jude Medical, Inc. common stock as reported on the New
York Stock Exchange on December 2, 2005.
(3)
Includes corresponding rights to acquire shares of
St. Jude Medical, Inc. preferred stock pursuant to the Rights Agreement, dated as of June 16, 1997 and amended as of December 20,
2002, between St. Jude Medical, Inc. and American Stock Transfer and Trust Company.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.    Incorporation of Documents by Reference.
The following documents,
which have been filed with the Securities and Exchange Commission (the "SEC") by St. Jude Medical, Inc. ("we,"
"us" or "St. Jude"), are incorporated by reference in this registration statement:
(a)
Our Annual Report on Form 10-K for the year ended December 31,
2004;
(b)
Our Quarterly Reports on Form 10-Q for the quarters ended March
31, 2005, June 30, 2005 and September 30, 2005;
(c)
Our Current Reports on Form 8-K filed on January 14, 2005,
February 15, 2005, March 2, 2005, March 4, 2005, April 7, 2005, April 25, 2005, May 12, 2005, August 8, 2005, October 7, 2005,
October 12, 2005, October 17, 2005 (except as to Item 7.01 thereof), October 25, 2005 and November 21, 2005 (as amended by our
Current Report on Form 8-K/A filed on December 5, 2005); and
(d)
The description of our common stock and preferred stock purchase
rights contained in any registration statement or report filed by us under the Securities Exchange Act of 1934, as amended (the
"Exchange Act"), including any amendment or report filed for the purpose of updating such description.
All documents filed by us
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the date hereof and prior to the filing of
a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities
remaining unsold shall be deemed to be incorporated by reference herein and to be a part hereof from the respective dates of
filing of such documents.
Item 4.    Description of Securities.
Not applicable.
Item 5.    Interests of Named Experts and Counsel.
Not applicable.
Item 6.    Indemnification of Directors and Officers.
Section 521 of the
Minnesota Business Corporation Act provides that a company shall, subject to certain limitations, indemnify officers and directors
made or threatened to be made a party to a proceeding by reason of that officer or director's former or present official
capacity with the company. As required, we will indemnify that person against judgments, penalties, fines, settlements and
reasonable expenses if the officer or director:
•
has not been indemnified by another organization;
•
acted in good faith;
•
has not received an improper personal benefit and Section 255
regarding director conflicts of interests, if applicable, has been satisfied;
II-1
•
assuming the case is a criminal proceeding, the person had no
reasonable cause to believe the conduct was unlawful; and
•
reasonably believed that the conduct was in the best interests of
the company or, in the case of an officer or director who is or was serving at the request of the company as a director, officer,
partner, trustee, employee or agent of another organization or employee benefit plan, reasonably believed that the conduct was not
opposed to the best interests of the company.
Article XIV of our Articles
of Incorporation, as amended and restated, provides that, to the fullest extent permissible under the Minnesota Business
Corporation Act, our directors shall not be liable to St. Jude or our shareholders for monetary damages for breach of fiduciary
duty as a director.
Article
VII of our Bylaws, as amended and restated, provides that we shall indemnify our officers
and directors under such circumstances and to the extent permitted by Section 521 of the
Minnesota Business Corporation Act described above.
We enter into indemnification
agreements with our directors and officers. The indemnification agreements provide that we shall, subject to certain limitations,
indemnify our directors and officers who are made or threatened to be made a party to a proceeding by reason of that
director's or officer's former or present official capacity with St. Jude Medical. The circumstances under which we will
indemnify our directors or officers against judgments, penalties, fines, settlements and reasonable expenses pursuant to these
indemnification agreements are the same as those provided in Section 521 of the Minnesota Business Corporation Act described
above.
We maintain directors'
and officers' liability insurance which covers certain liabilities and expenses of our directors and officers and covers St.
Jude for reimbursement of payments to our directors and officers in respect of such liabilities and expenses.
Item 7.    Exemption from Registration Claimed.
Not applicable.
II-2
Item 8.    Exhibits.
4.1
Articles of Incorporation, as restated as of February 25, 2005
(incorporated by reference from Exhibit 3.1 of the Company's Annual Report on Form 10-K for the year ended December 31,
2004).
4.2
Bylaws, as amended and restated as of February 25, 2005
(incorporated by reference from Exhibit 3.1 of the Company's Current Report on Form 8-K dated March 2, 2005).
4.3
Rights Agreement dated as of June 16, 1997, between the Company
and American Stock Transfer and Trust Company, as Rights Agent, including the Certificate of Designation, Preferences and Rights
of Series B Junior Preferred Stock (incorporated by reference from Exhibit 4 of the Company's Quarterly Report on Form 10-Q
for the quarter ended June 30, 1997).
4.4
Amendment, dated as of December 20, 2002, to Rights Agreement,
dated as of June 16, 1997 (incorporated by reference from Exhibit 1 of the Company's Current Report on Form 8-K filed on
March 21, 2003).
5.1
Opinion of Dorsey & Whitney LLP.
23.1
Consent of Dorsey & Whitney LLP (included in Exhibit 5.1).
23.2
Consent of Ernst & Young LLP.
23.3
Consent of Ernst & Young LLP.
24.1
Power of Attorney.
Item 9.    Undertakings.
(a)       The undersigned registrant hereby undertakes:
(1)       To
file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
(i)       To
include any prospectus required by Section 10(a)(3) of the Securities Act of 1933, as amended (the "Securities
Act");
(ii)       To
reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set
forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if
the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high
end of the estimated maximum offering range may be reflected in the form of prospectus filed with the SEC pursuant to
Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum
aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration
statement; and
(iii)                      To
include any material information with respect to the plan of distribution not
               previously disclosed in the registration statement or any material change
to                such information in the registration statement;
provided
,
however,
that paragraphs (a)(1)(i) and (a)(1)(ii) above do not apply if the
information required to be included in a post-effective amendment by those paragraphs is
contained in periodic reports filed with or furnished to the SEC by the registrant
pursuant to Section 13 or Section 15(d) of the Exchange Act that are
incorporated by reference in the registration statement.
II-3
(2)       That,
for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a
new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.
(3)       To
remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
termination of the offering.
(b)       The
undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of
the registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated
by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c)       Insofar
as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion
of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In
the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the
registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.
II-4
SIGNATURES
Pursuant to the requirements
of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of St. Paul, State of Minnesota, on December 7, 2005.
ST. JUDE MEDICAL, INC.
By:
/s/ Daniel J. Starks
Daniel J. Starks
President, Chief Executive Officer and Chairman
Pursuant to the requirements
of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities
indicated on December 7, 2005.
Signature
Title
/s/ Daniel J. Starks
President, Chief Executive Officer and Chairman
Daniel J. Starks
(principal executive officer)
/s/ John C. Heinmiller
Executive Vice President and Chief Financial Officer
John C. Heinmiller
(principal financial and accounting officer)
*
Director
John W. Brown
*
Director
Richard R. Devenuti
*
Director
Stuart M. Essig
*
Director
Thomas H. Garrett III
*
Director
Michael A. Rocca
*
Director
David A. Thompson
*
Director
Stefan K. Widensohler
*
Director
Wendy L. Yarno
*
Director
Frank C-P Yin
*By:
/s/ Kevin T. O'Malley
Kevin T. O'Malley
Attorney-in-Fact
II-5
EXHIBIT INDEX
Exhibit
Number
Description
4.1
Articles of Incorporation, as restated as of February 25, 2005
(incorporated by reference from Exhibit 3.1 of the Company's Annual Report on Form 10-K for the year ended December 31, 2004).
4.2
Bylaws, as amended and restated as of February 25, 2005
(incorporated by reference from Exhibit 3.1 of the Company's Current Report on Form 8-K dated March 2, 2005).
4.3
Rights Agreement dated as of June 16, 1997, between the Company
and American Stock Transfer and Trust Company, as Rights Agent, including the Certificate of Designation, Preferences and Rights
of Series B Junior Preferred Stock (incorporated by reference from Exhibit 4 of the Company's Quarterly Report on Form 10-Q for
the quarter ended June 30, 1997).
4.4
Amendment, dated as of December 20, 2002, to Rights Agreement,
dated as of June 16, 1997 (incorporated by reference from Exhibit 1 of the Company's Current Report on Form 8-K filed on March 21,
2003).
5.1
Opinion of Dorsey & Whitney LLP.
23.1
Consent of Dorsey & Whitney LLP (included in Exhibit 5.1).
23.2
Consent of Ernst & Young LLP.
23.3
Consent of Ernst & Young LLP.
24.1
Power of Attorney.