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<TITLE>Form S-8
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<P ALIGN=CENTER>As filed with the Securities and Exchange Commission on May 29, 2001. </P>

                                             <P ALIGN=RIGHT>Registration No. 333-______________</P>
<HR>
                       <CENTER><B>SECURITIES AND EXCHANGE COMMISSION<BR>
                             Washington, D.C. 20549<BR><BR><BR>


                                    FORM S-8<BR>
                             REGISTRATION STATEMENT<BR>
                                      UNDER<BR>
                           THE SECURITIES ACT OF 1933</B></CENTER><BR><BR>

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<TD WIDTH=25% ALIGN=CENTER><P>Incorporated<BR> Under the Laws<BR> of Ohio </P></TD>
<TD WIDTH=50% ALIGN=CENTER><P><B>KENDLE INTERNATIONAL INC.</B><BR>441 Vine Street, Suite 700
<BR>
Cincinnati, Ohio  45202<BR>(513) 771-8221 </P></TD>
<TD WIDTH=25% ALIGN=CENTER><P>I.R.S. Employer<BR>Identification No.<BR>
         31-1274091
</P>
</TD>
</TR>
</TABLE>
<BR><BR>
<CENTER> <B>1995 &amp; 1997 STOCK OPTION PLAN AND STOCK INCENTIVE PLAN
</B></CENTER>
<BR><BR>

                              <CENTER> <B>Gary P. Kreider, Esq.<BR>
                         Keating, Muething &amp; Klekamp, P.L.L.<BR>
                             One East Fourth Street<BR>
                             Cincinnati, Ohio 45202<BR>
                                 (513) 579-6411<BR>Facsimile (513) 579-6956</B><BR>
                         (Agent for Service of Process)</CENTER>
<BR><BR>


                         <CENTER><B>CALCULATION OF REGISTRATION FEE</B></CENTER>

<BR><BR>
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<TD WIDTH=20% ALIGN=CENTER><P><BR><BR>Title of<BR>Securities
<BR><U>To Be Registered </U><BR>Common Stock,<BR>No par value</P></TD>
<TD WIDTH=20% ALIGN=CENTER><P><BR><BR>Amount<BR>To Be<BR><U>&nbsp;&nbsp;&nbsp;Registered(1)&nbsp;&nbsp;&nbsp;</U><BR>
2,000,000 Shares </P></TD>
<TD WIDTH=20% ALIGN=CENTER><P>Proposed<BR>Maximum<BR>Offering<BR>Price<BR><U>Per Share (2)</U><BR>
$16.215 </P></TD>
<TD WIDTH=20% ALIGN=CENTER><P>Proposed<BR>Maximum<BR>Aggregate<BR>Offering<BR><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Price(2)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
<BR>$32,430,000 </P></TD>
<TD WIDTH=20% ALIGN=CENTER><P><BR><BR>Amount of<BR>Registration<BR><U>&nbsp;&nbsp;&nbsp;&nbsp;Fee(3)&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
$8,108
</P>
</TD>
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<BR><BR>
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<TD WIDTH=5% ALIGN=CENTER><P>(1) </P></TD>
<TD WIDTH=95% ALIGN=LEFT><P>
This  Registration  Statement  is filed for up to an  additional  2,000,000
     shares  issuable  upon the  exercise  of options  granted  pursuant  to the
     Kendle International Inc. 1997 Stock Option and Stock Incentive Plan.  This
Registration Statement does not cover any additional shares issuable upon the exercise
of options granted pursuant to the Kendle International Inc. 1995 Stock Option and
Stock Incentive Plan.</P>
</TD>
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</TABLE>
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<TD WIDTH=5% ALIGN=CENTER><P>(2) </P></TD>
<TD WIDTH=95% ALIGN=LEFT><P>Estimated to calculate registration fee.</P>
</TD>
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<TD WIDTH=5% ALIGN=CENTER><P>(3) </P></TD>
<TD WIDTH=95% ALIGN=LEFT><P> Calculated pursuant to
Rule 457(h) based on the average of the high and low prices of the Common Stock
on the Nasdaq Stock Market on May 22, 2001 at $16.215 per share.
</P>
</TD>
</TR>
</TABLE>

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;     The contents of Registration No. 333-34261,
 as filed with the Securities and Exchange Commission on
August 22, 1997, are incorporated herein by reference.
</P>
<P><B>Item 8.  Exhibits*</B></P>

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<TD WIDTH=5% ALIGN=LEFT><P></P></TD>
<TD WIDTH=15% ALIGN=LEFT><P>Exhibit 4.1<BR><BR><BR>Exhibit 4.2<BR><BR><BR>Exhibit 5<BR><BR>
Exhibit 23.1<BR><BR>Exhibit 23.2<BR><BR>Exhibit 24 </P></TD>
<TD WIDTH=80% ALIGN=LEFT><P>1995 Stock Option and Stock Incentive Plan (incorporated
by reference to Kendle's Form S-8, File No. 333-34261, filed with the SEC
on August 22, 1997)<BR><BR>1997 Stock Option and Stock Incentive Plan (incorporated
by reference to Kendle's Form S-8, File No. 333-34261, filed with the SEC
on August 22, 1997)<BR><BR>Opinion of Keating, Muething &amp; Klekamp, P.L.L.
<BR><BR>Consent of Pricewaterhouse Coopers LLP
<BR><BR>Consent of Keating, Muething &amp; Klekamp, P.L.L.
                  (included in Exhibit 5)
<BR><BR>Power of Attorney (contained on the signature page)
</P>
</TD>
</TR>
</TABLE>
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<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;*
Filed herewith unless otherwise indicated. </P>

                                  <CENTER> <B>SIGNATURES</B>
</CENTER><BR><BR>
<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the
requirements of the Securities Act of 1933, the registrant certifies that it has
reasonable grounds to believe that it meets all of the requirements for filing
on Form S-8 and has duly caused this Registration Statement to be signed on its
behalf by the undersigned, thereunto duly authorized, in Cincinnati, Ohio, on
May 29, 2001. </P>

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<TD WIDTH=55% ALIGN=RIGHT><P> </P></TD>
<TD WIDTH=45%><P> KENDLE INTERNATIONAL INC.<BR><BR><BR><BR>
By:<U>&nbsp;&nbsp;&nbsp; /s/Candace Kendle&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Candace Kendle<BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Chairman of the Board and<BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Chief Executive Officer<BR>
</P>
</TD>
</TR>
</TABLE>
<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the
requirements of the Securities Act of 1933, this Registration Statement has been
signed by the following persons in the capacities and on the dates indicated.
Persons whose names are marked with an asterisk (*) below hereby
designate Candace Kendle or Timothy M. Mooney as their
attorney-in-fact to sign all amendments, including any post-effective amendments, to this
Registration Statement. </P>

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<TD WIDTH=40% ALIGN=LEFT><P><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Signature&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR><BR><U>*/s/Candace Kendle
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</U><BR>Candace Kendle<BR><BR><BR><U> */s/Christopher C. Bergen
&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

</U><BR>Christopher C. Bergen<BR><BR><U>*/s/Timothy M. Mooney
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</U><BR>Timothy M. Mooney<BR><BR><BR><BR><BR><U>*/s/Philip E. Beekman&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

</U><BR>Philip E. Beckman<BR><BR><BR><U>*/s/Charles A. Sanders

&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</U><BR>Charles A. Sanders<BR><BR><BR><U>*&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;


&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</U><BR>Robert R. Buck</P></TD>
<TD WIDTH=40% ALIGN=LEFT><P><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Capacity&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR><BR>Chairman of the Board and<BR>
Chief Executive Officer<BR> (Principal
Executive Officer)<BR><BR>President, Chief Operating Officer<BR>and Director<BR><BR>Executive Vice-President
Finance,<BR>Chief Financial Officer<BR>(principal financial officer<BR>and principal accounting <BR>
officer) and Director<BR><BR>Director<BR><BR><BR><BR>Director<BR><BR><BR><BR>Director
 </P></TD>
<TD WIDTH=20% ALIGN=CENTER><P><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Date
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR><BR>May 29, 2001<BR><BR><BR>
<BR>May 29, 2001<BR><BR><BR>May 29, 2001<BR><BR><BR><BR><BR><BR>May 29, 2001<BR><BR><BR><BR>
May 29, 2001<BR><BR><BR><BR>May __, 2001</P>
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Form S-8
As filed with the Securities and Exchange Commission on May 29, 2001.
Registration No. 333-______________
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Incorporated
Under the Laws
of Ohio
KENDLE INTERNATIONAL INC.
441 Vine Street, Suite 700
Cincinnati, Ohio  45202
(513) 771-8221
I.R.S. Employer
Identification No.
31-1274091
1995 & 1997 STOCK OPTION PLAN AND STOCK INCENTIVE PLAN
Gary P. Kreider, Esq.
Keating, Muething & Klekamp, P.L.L.
One East Fourth Street
Cincinnati, Ohio 45202
(513) 579-6411
Facsimile (513) 579-6956
(Agent for Service of Process)
CALCULATION OF REGISTRATION FEE
Title of
Securities
To Be Registered
Common Stock,
No par value
Amount
To Be
Registered(1)
2,000,000 Shares
Proposed
Maximum
Offering
Price
Per Share (2)
$16.215
Proposed
Maximum
Aggregate
Offering
Price(2)
$32,430,000
Amount of
Registration
Fee(3)
$8,108
(1)
This  Registration  Statement  is filed for up to an  additional  2,000,000
     shares  issuable  upon the  exercise  of options  granted  pursuant  to the
     Kendle International Inc. 1997 Stock Option and Stock Incentive Plan.  This
Registration Statement does not cover any additional shares issuable upon the exercise
of options granted pursuant to the Kendle International Inc. 1995 Stock Option and
Stock Incentive Plan.
(2)
Estimated to calculate registration fee.
(3)
Calculated pursuant to
Rule 457(h) based on the average of the high and low prices of the Common Stock
on the Nasdaq Stock Market on May 22, 2001 at $16.215 per share.
The contents of Registration No. 333-34261,
 as filed with the Securities and Exchange Commission on
August 22, 1997, are incorporated herein by reference.
Item 8.  Exhibits*
Exhibit 4.1
Exhibit 4.2
Exhibit 5
Exhibit 23.1
Exhibit 23.2
Exhibit 24
1995 Stock Option and Stock Incentive Plan (incorporated
by reference to Kendle's Form S-8, File No. 333-34261, filed with the SEC
on August 22, 1997)
1997 Stock Option and Stock Incentive Plan (incorporated
by reference to Kendle's Form S-8, File No. 333-34261, filed with the SEC
on August 22, 1997)
Opinion of Keating, Muething & Klekamp, P.L.L.
Consent of Pricewaterhouse Coopers LLP
Consent of Keating, Muething & Klekamp, P.L.L.
                  (included in Exhibit 5)
Power of Attorney (contained on the signature page)
*
Filed herewith unless otherwise indicated.
SIGNATURES
Pursuant to the
requirements of the Securities Act of 1933, the registrant certifies that it has
reasonable grounds to believe that it meets all of the requirements for filing
on Form S-8 and has duly caused this Registration Statement to be signed on its
behalf by the undersigned, thereunto duly authorized, in Cincinnati, Ohio, on
May 29, 2001.
KENDLE INTERNATIONAL INC.
By:
/s/Candace Kendle
Candace Kendle
Chairman of the Board and
Chief Executive Officer
Pursuant to the
requirements of the Securities Act of 1933, this Registration Statement has been
signed by the following persons in the capacities and on the dates indicated.
Persons whose names are marked with an asterisk (*) below hereby
designate Candace Kendle or Timothy M. Mooney as their
attorney-in-fact to sign all amendments, including any post-effective amendments, to this
Registration Statement.
Signature
*/s/Candace Kendle
Candace Kendle
*/s/Christopher C. Bergen
Christopher C. Bergen
*/s/Timothy M. Mooney
Timothy M. Mooney
*/s/Philip E. Beekman
Philip E. Beckman
*/s/Charles A. Sanders
Charles A. Sanders
*
Robert R. Buck
Capacity
Chairman of the Board and
Chief Executive Officer
(Principal
Executive Officer)
President, Chief Operating Officer
and Director
Executive Vice-President
Finance,
Chief Financial Officer
(principal financial officer
and principal accounting
officer) and Director
Director
Director
Director
Date
May 29, 2001
May 29, 2001
May 29, 2001
May 29, 2001
May 29, 2001
May __, 2001