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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>As filed with the Securities and Exchange Commission on June 12, 2002</FONT></P>

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<P ALIGN="RIGHT"><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>Registration No.
333-____________ </FONT></P>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2><B>SECURITIES AND EXCHANGE COMMISSION</B><BR>
Washington, D.C. 20549
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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2><B>FORM S-8<BR>
REGISTRATION STATEMENT</B><BR>
<I>Under<BR>
The Securities Act of 1933</I></FONT></P>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2><B>BIOCRYST PHARMACEUTICALS, INC.</B><BR>
(Exact name of registrant as specified in its charter)</FONT></P>

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<B>Delaware</B><BR>
(State or other jurisdiction <BR>
of incorporation or organization)<BR>
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<B>62-1413174</B><BR>
(IRS Employer Identification No.)
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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2><B>2190 Parkway Lake Drive<BR>
Birmingham, Alabama 35244<BR></B>
(Address of principal executive offices) (Zip Code)</FONT></P>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2><B>EMPLOYEE STOCK PURCHASE PLAN</B><BR>
(Full title of the Plan)</FONT></P>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2><B>Charles E. Bugg, Ph.D.<BR>
Chairman and Chief Executive Officer<BR>
BioCryst Pharmaceuticals<BR>
2190 Parkway Lake Drive<BR>
Birmingham, Alabama 35244<BR></B>
(Name and address of agent for service)<BR>
<B>(205) 444-4600<BR></B>
(Telephone number, including area code, of agent for service)</FONT></P>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>CALCULATION
OF REGISTRATION FEE</FONT></H1>

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     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Title of Securities to be Registered</FONT><HR WIDTH=100% SIZE=1 NOSHADE> </TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="1">&nbsp;</FONT></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Amount to be<BR>Registered(1) </FONT><HR SIZE=1 NOSHADE> </TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="1">&nbsp;</FONT></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Proposed<BR>Maximum Offering<BR>Price per Share(2) </FONT><HR SIZE=1 NOSHADE> </TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="1">&nbsp;</FONT></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Proposed<BR>Maximum Aggregate<BR>Offering Price(2) </FONT><HR SIZE=1 NOSHADE> </TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="1">&nbsp;</FONT></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Amount of<BR>Registration Fee </FONT><HR SIZE=1 NOSHADE></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="1">&nbsp;</FONT></TH></TR>
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     <TD WIDTH="28%" ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2><U>Employee Stock Purchase Plan</U></FONT> </TD>
     <TD WIDTH="3%" ALIGN="LEFT">&nbsp;</TD>
     <TD WIDTH="15%" ALIGN="RIGHT"></TD>
     <TD WIDTH="3%" ALIGN="LEFT">&nbsp;</TD>
     <TD WIDTH="15%" ALIGN="RIGHT"></TD>
     <TD WIDTH="3%" ALIGN="LEFT">&nbsp;</TD>
     <TD WIDTH="15%" ALIGN="RIGHT"></TD>
     <TD WIDTH="3%" ALIGN="LEFT">&nbsp;</TD>
     <TD WIDTH="12%" ALIGN="RIGHT"></TD>
     <TD WIDTH="3%" ALIGN="LEFT">&nbsp;</TD></TR>
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     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Common Stock, $0.01 par value</FONT></TD>
     <TD ALIGN="LEFT">&nbsp;</TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>200,000 shares</FONT></TD>
     <TD ALIGN="LEFT">&nbsp;</TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>$3.05</FONT></TD>
     <TD ALIGN="LEFT">&nbsp;</TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>$610,000</FONT></TD>
     <TD ALIGN="LEFT">&nbsp;</TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>$56.12</FONT></TD>
     <TD ALIGN="LEFT">&nbsp;</TD></TR>
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<TD WIDTH=3%><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=1>(1)</FONT></TD>
<TD WIDTH=3%><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=1></FONT></TD>
<TD WIDTH=94%><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=1>This
Registration Statement shall also cover any additional shares of Common Stock which
become issuable under the Employee Stock Purchase Plan by reason of any stock dividend,
stock split, recapitalization or other similar transaction effected without the Registrant&#146;s
receipt of consideration which results in an increase in the number of the outstanding
shares of Registrant&#146;s Common Stock.</FONT></TD>
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<TD WIDTH=3%><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=1>(2)</FONT></TD>
<TD WIDTH=3%><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=1></FONT></TD>
<TD WIDTH=94%><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=1>Calculated
solely for purposes of this offering under Rule 457(h) of the Securities Act of 1933, as
amended, on the basis of the average of the high and low selling prices per share of
Registrant&#146;s Common Stock on June 6, 2002, as reported by the Nasdaq National Market.</FONT></TD>
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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>PART II</FONT></H1>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Information
Required in the Registration Statement</FONT></H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 3.  <I>Incorporation of Documents by Reference</I></FONT></P>

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<P><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;BioCryst Pharmaceuticals, Inc. (the &#147;Registrant&#148;) hereby incorporates by reference into this Registration
Statement the contents of the Registration Statement on Form S-8 (File No. 33-95062) filed on July 25, 1995.</FONT></P>

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<P><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Employee Stock Purchase Plan (the &#147;ESP Plan&#148;) was amended by a vote of
the Registrant&#146;s stockholders on May 15, 2002. The amendment to the ESP
Plan (i) increased the number of shares available under the ESP Plan by 200,000,
and (ii) eliminated the January 2005 termination date of the ESP Plan. The ESP
Plan will now expire upon the earlier of (i) the date on which all shares
available for issuance under the ESP Plan shall have been sold pursuant to the
purchase rights exercised under the ESP Plan or (ii) the date on which all
purchase rights are exercised in connection with an Acquisition (as defined in
the ESP Plan). A copy of the ESP Plan as amended is attached hereto as Exhibit
99.1. </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 8.  <I>Exhibits</I></FONT></P>

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     <TH WIDTH=12%><FONT FACE="Times New Roman, Times, Serif" SIZE=1><I>Exhibit Number</I></FONT><HR SIZE=1 NOSHADE></TH>
     <TH WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=1></FONT></TH>
     <TH WIDTH=83% ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=1><I>Exhibit</I></FONT><HR SIZE=1 NOSHADE WIDTH="7%"></TH></TR>
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     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
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     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>5</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Opinion and consent of Brobeck, Phleger &amp; Harrison LLP.</FONT></TD></TR>
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     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>23.1</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Consent of Ernst &amp; Young LLP, Independent Auditors.</FONT></TD></TR>
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     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>23.2</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Consent of Brobeck, Phleger &amp; Harrison LLP is contained in Exhibit 5.</FONT></TD></TR>
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     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>99.1</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Employee Stock Purchase Plan.</FONT></TD></TR>
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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>II-1</FONT></P>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>SIGNATURES</FONT></H1>

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<P><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, as amended, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8, and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Birmingham, State of Alabama on this 13th day of
June, 2002. </FONT></P>

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<TD WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><BR><BR>By:</FONT></TD>
<TD WIDTH=50%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
<B>BIOCRYST PHARMACEUTICALS, INC.</B><BR><BR>
/s/ Charles E. Bugg<BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Charles E. Bugg, Ph.D.<BR>
Chief Executive Officer
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<P><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, as amended, this Registration
Statement has been signed below by the following persons in the capacities and
on the dates indicated. </FONT></P>

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     <TH WIDTH=30%><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Signature</FONT><HR SIZE=1 NOSHADE></TH>
     <TH WIDTH=40%><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Title</FONT><HR SIZE=1 NOSHADE WIDTH="90%"></TH>
     <TH WIDTH=30%><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Date</FONT><HR SIZE=1 NOSHADE WIDTH="90%"></TH></TR>
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     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
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     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
/s/ Charles E. Bugg<BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Charles E. Bugg, Ph.D.
</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Chairman, Chief Executive Officer and<BR>Director (Principal Executive Officer)</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>June 13, 2002</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>/s/ J. Claude Bennett<BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
J. Claude Bennett, M.D.
</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>President, Chief Operating Officer,<BR>Medical Director and Director</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>June 13, 2002</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>/s/ W. Randall Pittman<BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
W. Randall Pittman
</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Chief Financial Officer, Treasurer and Secretary<BR>(Principal Financial and Accounting Officer)</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>June 13, 2002</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>/s/ William W. Featheringill<BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
William W. Featheringill
</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Director</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>June 13, 2002</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>/s/ Edwin A. Gee<BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Edwin A. Gee, Ph.D.
</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Director</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>June 13, 2002</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>/s/ Zola P. Horovitz<BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Zola P. Horovitz, Ph.D.
</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Director</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>June 13, 2002</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>/s/ John A. Montgomery<BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
John A. Montgomery, Ph.D.
</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Director</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>June 13, 2002</FONT></TD></TR>
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     <TH WIDTH=30%><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Signature</FONT><HR SIZE=1 NOSHADE></TH>
     <TH WIDTH=40%><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Title</FONT><HR SIZE=1 NOSHADE WIDTH="90%"></TH>
     <TH WIDTH=30%><FONT FACE="Times New Roman, Times, Serif" SIZE=1>Date</FONT><HR SIZE=1 NOSHADE WIDTH="90%"></TH></TR>
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     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
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     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2><BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Joseph H. Sherrill, Jr.
</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Director</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>June 13, 2002</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>/s/ William M. Spencer, III<BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
William M. Spencer, III
</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Director</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>June 13, 2002</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>/s/ Randolph C. Steer<BR>
&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Randolph C. Steer, M.D., Ph.D.
</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Director</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>June 13, 2002</FONT></TD></TR>
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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>II-3</FONT></P>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>SECURITIES AND EXCHANGE COMMISSION</FONT></P>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>WASHINGTON, D.C. 20549</FONT></P>

<BR>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>EXHIBITS</FONT></P>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>TO</FONT></P>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>FORM S-8</FONT></P>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>UNDER</FONT></P>

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<P ALIGN=CENTER><FONT FACE="TIMES NEW ROMAN, TIMES, SERIF" SIZE=2>SECURITIES ACT OF 1933</FONT></P>

<BR>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>BIOCRYST
PHARMACEUTICALS, INC.</FONT></H1>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>EXHIBIT INDEX</FONT></H1>

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<TABLE WIDTH=600 CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
     <TH WIDTH=12%><FONT FACE="Times New Roman, Times, Serif" SIZE=1><I>Exhibit Number</I></FONT><HR SIZE=1 NOSHADE></TH>
     <TH WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=1></FONT></TH>
     <TH WIDTH=83% ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=1><I>Exhibit</I></FONT><HR SIZE=1 NOSHADE WIDTH="7%"></TH></TR>
<TR VALIGN="BOTTOM">
     <TD COLSPAN="3" ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>5</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Opinion and consent of Brobeck, Phleger &amp; Harrison LLP.</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>23.1</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Consent of Ernst &amp; Young LLP, Independent Auditors.</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>23.2</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Consent of Brobeck, Phleger &amp; Harrison LLP is contained in Exhibit 5.</FONT></TD></TR>
<TR VALIGN=TOP>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>99.1</FONT></TD>
     <TD ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
     <TD ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Employee Stock Purchase Plan.</FONT></TD></TR>
</TABLE>

</BODY></HTML>
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{"company-data": {"conformed-name": "BIOCRYST PHARMACEUTICALS INC", "cik": "0000882796", "assigned-sic": "2836", "irs-number": "621413174", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-90582", "film-number": "02679988"}, "business-address": {"street1": "2190 PKWY LAKE DR", "city": "BIRMINGHAM", "state": "AL", "zip": "35244", "phone": "2054444600"}, "mail-address": {"street1": "2190 PARKWAY LAKE DR", "city": "BIRMINGHAM", "state": "AL", "zip": "35244"}}
S-8
As filed with the Securities and Exchange Commission on June 12, 2002
Registration No.
333-____________
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
BIOCRYST PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)
Delaware
(State or other jurisdiction
of incorporation or organization)
62-1413174
(IRS Employer Identification No.)
2190 Parkway Lake Drive
Birmingham, Alabama 35244
(Address of principal executive offices) (Zip Code)
EMPLOYEE STOCK PURCHASE PLAN
(Full title of the Plan)
Charles E. Bugg, Ph.D.
Chairman and Chief Executive Officer
BioCryst Pharmaceuticals
2190 Parkway Lake Drive
Birmingham, Alabama 35244
(Name and address of agent for service)
(205) 444-4600
(Telephone number, including area code, of agent for service)
CALCULATION
OF REGISTRATION FEE
Title of Securities to be Registered
Amount to be
Registered(1)
Proposed
Maximum Offering
Price per Share(2)
Proposed
Maximum Aggregate
Offering Price(2)
Amount of
Registration Fee
Employee Stock Purchase Plan
Common Stock, $0.01 par value
200,000 shares
$3.05
$610,000
$56.12
(1)
This
Registration Statement shall also cover any additional shares of Common Stock which
become issuable under the Employee Stock Purchase Plan by reason of any stock dividend,
stock split, recapitalization or other similar transaction effected without the Registrant's
receipt of consideration which results in an increase in the number of the outstanding
shares of Registrant's Common Stock.
(2)
Calculated
solely for purposes of this offering under Rule 457(h) of the Securities Act of 1933, as
amended, on the basis of the average of the high and low selling prices per share of
Registrant's Common Stock on June 6, 2002, as reported by the Nasdaq National Market.
PART II
Information
Required in the Registration Statement
Item 3.
Incorporation of Documents by Reference
BioCryst Pharmaceuticals, Inc. (the "Registrant") hereby incorporates by reference into this Registration
Statement the contents of the Registration Statement on Form S-8 (File No. 33-95062) filed on July 25, 1995.
The
Employee Stock Purchase Plan (the "ESP Plan") was amended by a vote of
the Registrant's stockholders on May 15, 2002. The amendment to the ESP
Plan (i) increased the number of shares available under the ESP Plan by 200,000,
and (ii) eliminated the January 2005 termination date of the ESP Plan. The ESP
Plan will now expire upon the earlier of (i) the date on which all shares
available for issuance under the ESP Plan shall have been sold pursuant to the
purchase rights exercised under the ESP Plan or (ii) the date on which all
purchase rights are exercised in connection with an Acquisition (as defined in
the ESP Plan). A copy of the ESP Plan as amended is attached hereto as Exhibit
99.1.
Item 8.
Exhibits
Exhibit Number
Exhibit
5
Opinion and consent of Brobeck, Phleger & Harrison LLP.
23.1
Consent of Ernst & Young LLP, Independent Auditors.
23.2
Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5.
99.1
Employee Stock Purchase Plan.
II-1
SIGNATURES
Pursuant
to the requirements of the Securities Act of 1933, as amended, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8, and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Birmingham, State of Alabama on this 13th day of
June, 2002.
By:
BIOCRYST PHARMACEUTICALS, INC.
/s/ Charles E. Bugg
——————————————
Charles E. Bugg, Ph.D.
Chief Executive Officer
Pursuant
to the requirements of the Securities Act of 1933, as amended, this Registration
Statement has been signed below by the following persons in the capacities and
on the dates indicated.
Signature
Title
Date
/s/ Charles E. Bugg
————————————
Charles E. Bugg, Ph.D.
Chairman, Chief Executive Officer and
Director (Principal Executive Officer)
June 13, 2002
/s/ J. Claude Bennett
————————————
J. Claude Bennett, M.D.
President, Chief Operating Officer,
Medical Director and Director
June 13, 2002
/s/ W. Randall Pittman
————————————
W. Randall Pittman
Chief Financial Officer, Treasurer and Secretary
(Principal Financial and Accounting Officer)
June 13, 2002
/s/ William W. Featheringill
————————————
William W. Featheringill
Director
June 13, 2002
/s/ Edwin A. Gee
————————————
Edwin A. Gee, Ph.D.
Director
June 13, 2002
/s/ Zola P. Horovitz
————————————
Zola P. Horovitz, Ph.D.
Director
June 13, 2002
/s/ John A. Montgomery
————————————
John A. Montgomery, Ph.D.
Director
June 13, 2002
II-2
Signature
Title
Date
————————————
Joseph H. Sherrill, Jr.
Director
June 13, 2002
/s/ William M. Spencer, III
————————————
William M. Spencer, III
Director
June 13, 2002
/s/ Randolph C. Steer
————————————
Randolph C. Steer, M.D., Ph.D.
Director
June 13, 2002
II-3
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
EXHIBITS
TO
FORM S-8
UNDER
SECURITIES ACT OF 1933
BIOCRYST
PHARMACEUTICALS, INC.
EXHIBIT INDEX
Exhibit Number
Exhibit
5
Opinion and consent of Brobeck, Phleger & Harrison LLP.
23.1
Consent of Ernst & Young LLP, Independent Auditors.
23.2
Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5.
99.1
Employee Stock Purchase Plan.