<HTML>
<HEAD>
<TITLE>Form S-8 Registration Statement
</TITLE>
</HEAD>
<BODY>
    <CENTER>As filed with the Securities and Exchange Commission on December 17, 2001</CENTER>
                               <CENTER>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</CENTER>

<HR>

                       <CENTER>SECURITIES AND EXCHANGE COMMISSION<BR>
                             Washington, D.C. 20549</CENTER>
<BR>
<HR SIZE=1 NOSHADE WIDTH=15% ALIGN=CENTER>

<H3 ALIGN=CENTER>FORM S-8<BR>

REGISTRATION STATEMENT<BR>

UNDER<BR>

THE SECURITIES ACT OF 1933</H3>

<HR SIZE=1 NOSHADE WIDTH=15% ALIGN=CENTER>
<BR>

<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=25% ALIGN=CENTER><P>Incorporated<BR>Under the Laws<BR>of Ohio </P></TD>
<TD WIDTH=40% ALIGN=CENTER><P>MERIDIAN BIOSCIENCE, INC. <BR>3471 River Hills Drive <BR>
CINCINNATI, OHIO  45244 <BR><BR>  </P></TD>
<TD WIDTH=25% ALIGN=CENTER><P>I.R.S. Employer<BR>
       Identification No.<BR>
        31-0888197

</P>
</TD>
</TR>
</TABLE>

<HR SIZE=1 NOSHADE WIDTH=15% ALIGN=CENTER>
<BR>
                    <CENTER>1999 DIRECTORS' STOCK OPTION PLAN<BR><BR>
                           AMENDED AND RESTATED 1996 STOCK OPTION PLAN</CENTER>
                                   <BR>
<HR SIZE=1 NOSHADE WIDTH=15% ALIGN=CENTER>
<BR>
                            <CENTER> Robert E. Coletti, Esq.<BR>
              Keating, Muething &amp; Klekamp, P.L.L.<BR>
                         One East Fourth Street<BR>
                             Cincinnati, Ohio 45202<BR>
                               (513) 579-6560<BR>
                               (Agent for Service)</CENTER>
<BR>
<H4 ALIGN=CENTER>CALCULATION
OF REGISTRATION FEE</H4>
<TABLE CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=3% ALIGN=CENTER><P> <BR><BR><B>Title of<BR>Securities<BR>To Be Registered</B><BR>
<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR><BR>Common Stock,
<BR>No par value</P></TD>
<TD WIDTH=3% ALIGN=CENTER><P> <BR><BR><B>Amount<BR>To Be<BR>Registered(1)</B><BR>
<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR><BR>500,000 Shares</P></TD>
<TD WIDTH=3% ALIGN=CENTER><P><B>Proposed<BR>Maximum<BR>Offering<BR>Price<BR>Per Share(2)</B><BR>
<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR><BR>
$5.86 </P></TD>
<TD WIDTH=3% ALIGN=CENTER><P> <B>Proposed<BR>Maximum<BR>Aggregate<BR>Offering<BR>Price(2)</B><BR>
<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR><BR>$1,800,000</P></TD>
<TD WIDTH=3% ALIGN=CENTER><P><B><BR><BR> Amount of<BR>Registration<BR>Fee(3)</B><BR>
<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR><BR>$733

</P>
</TD>
</TR>
</TABLE>
<BR><BR>
<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=8% ALIGN=LEFT><P>(1) </P></TD>
<TD WIDTH=92% ALIGN=LEFT><P>
This Registration Statement is filed for up to an additional 500,000 shares
issuable upon the exercise of options granted pursuant to the Meridian
Bioscience, Inc. Amended and Restated 1996 Stock Option Plan. This Registration
Statement does not cover any additional shares issuable upon the exercise of
options granted pursuant to the 1999 Directors&#146; Stock Option Plan.
</P>
</TD>
</TR>
</TABLE>
<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=8% ALIGN=LEFT><P>(2) </P></TD>
<TD WIDTH=92% ALIGN=LEFT><P>
 Estimated solely for purposes of calculating registration fee.</P>
</TD>
</TR>
</TABLE>

<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=8% ALIGN=LEFT><P>(3) </P></TD>
<TD WIDTH=92% ALIGN=LEFT><P>
Calculated pursuant to Rule 457(h) based on the average of the high and low
prices of the Common Stock on the Nasdaq Stock Market on December 11, 2001 at
$5.86 per share.</P>
</TD>
</TR>
</TABLE>


<BR><BR>
<PAGE>



<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The  contents of Registration No. 333-74825, as
filed  with the  Commission  on March  22,  1999,  are  incorporated  herein  by
reference.</P>

<H4 ALIGN=LEFT>Item 8. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exhibits*</H4>


    <TABLE width=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=10% ALIGN=CENTER><P>4.1 </P></TD>
<TD WIDTH=90%><P>
Meridian  Bioscience,  Inc. 1999 Directors'  Stock Option Plan  (incorporated by
reference  to  Meridian's  Definitive  Proxy  Statement  filed  with  the SEC on
December 21, 1998)
</P>
</TD>
</TR>
</TABLE><BR>
    <TABLE width=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=10% ALIGN=CENTER><P>4.2 </P></TD>
<TD WIDTH=90%><P>
Meridian   Bioscience,   Inc.  Amended  and  Restated  1996  Stock  Option  Plan
(incorporated  by reference to Meridian's  Definitive Proxy Statement filed with
the SEC on December 21, 1998)
</P>
</TD>
</TR>
</TABLE><BR>
<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=10% ALIGN=CENTER><P>5 </P></TD>
<TD WIDTH=90%><P>    Opinion of Keating, Muething &amp; Klekamp, P.L.L.</P>
</TD>
</TR>
</TABLE>
<BR>
         <TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=10% ALIGN=CENTER><P>23.1</P></TD>
<TD WIDTH=90%><P>
 Consent  of  Arthur Andersen LLP</P>
</TD>
</TR>
</TABLE><BR>
         <TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=10% ALIGN=CENTER><P>23.2</P></TD>
<TD WIDTH=90%><P>
 Consent  of  Keating,  Muething  &amp;  Klekamp,  PLL  (contained  on
               Exhibit 5).</P>
</TD>
</TR>
</TABLE>
<BR>
<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=10% ALIGN=CENTER>24</TD>
<TD WIDTH=90%>
Power of Attorney (contained in the
signature page).</TD>
</TR>
</TABLE>
<BR>
<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
<P>*All exhibits are filed herewith unless otherwise indicated.</P>
<PAGE>

<H4 ALIGN=CENTER>SIGNATURES</H4>

<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant  to the requirements of the Securities
Act of 1933, the registrant  certifies that it has reasonable grounds to believe
that it meets all of the requirements for filing on Form S-8 and has duly caused
this  Registration  Statement  to be  signed on its  behalf by the  undersigned,
thereunto duly authorized, in Cincinnati, Ohio, on December 14, 2001.</P>

  <TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=50% ALIGN=RIGHT><P> </P></TD>
<TD WIDTH=50% ALIGN=LEFT><P>
 MERIDIAN BIOSCIENCE, INC.<BR><BR><BR><BR>



                                           By: <U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ William J. Motto
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
<BR>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;William J. Motto<BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Chairman of the Board and<BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Chief Executive Officer
</P>
</TD>
</TR>
</TABLE>


<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated. Each person whose signature appears below
marked with an asterisk hereby authorizes  William J. Motto and Melissa A. Lueke
as attorneys-in-fact
to sign on his/her behalf  individually  and in each capacity  indicated  below, any
amendments,   including   post-effective   amendments,   to  this   Registration
Statement.</P>

<TABLE WIDTH=100% CELLPADDING=0 CELLSPACING=0 BORDER=0>
<TR VALIGN=TOP>
<TD WIDTH=40% ALIGN=LEFT><P><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Signature&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
<BR><BR><U>*/s/William J. Motto&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U> <BR>William J. Motto<BR><BR><BR>
<U>*/s/John A. Kraeutler&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U> <BR>John A. Kraeutler<BR><BR>
<U>*/s/Melissa A. Lueke&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U> <BR>Melissa A. Lueke<BR><BR>
<BR><BR><BR>
<U>*/s/James A. Buzard&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U> <BR>James A. Buzard<BR><BR>
<U>*/s/Gary P. Kreider&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U> <BR>Gary P. Kreider<BR><BR>
<U>*/s/David C. Phillips
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;</U> <BR>David C. Phillips<BR><BR>
<U>*/s/Robert J. Ready
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U> <BR>Robert J. Ready<BR><BR>
</P></TD>
<TD WIDTH=40% ALIGN=LEFT><P><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Capacity&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U> <BR><BR>
Chairman of the Board<BR>and Chief Executive Officer<BR>(Principal Executive Officer)
<BR><BR>President, Chief Operating<BR>Officer and Director<BR><BR>Vice President, Secretary and<BR>
Chief Financial Officer<BR>(Principal Financial Officer<BR>and Principal Accounting<BR>Officer<BR><BR>
Director<BR><BR><BR>Director<BR><BR><BR>Director
<BR><BR><BR>Director<BR><BR></P></TD>
<TD WIDTH=20% ALIGN=LEFT><P><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Date
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR><BR>December 14, 2001<BR><BR><BR>
<BR>December 14, 2001<BR><BR><BR>December 14, 2001<BR><BR><BR><BR><BR><BR>December 14, 2001<BR><BR><BR>
December 14, 2001<BR><BR><BR>December 14, 2001<BR><BR><BR>December 14, 2001
</P>
</TD>
</TR>
</TABLE>
</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "meridians8121401.htm", "description": "FORM S-8 REGISTRATION STATEMENT", "secsgml_size_bytes": 11333}]
{"company-data": {"conformed-name": "MERIDIAN BIOSCIENCE INC", "cik": "0000794172", "assigned-sic": "2835", "irs-number": "310888197", "state-of-incorporation": "OH", "fiscal-year-end": "0930"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-75312", "film-number": "1816024"}, "business-address": {"street1": "3471 RIVER HILLS DR", "city": "CINCINNATI", "state": "OH", "zip": "45244", "phone": "5132713700"}, "mail-address": {"street1": "3471 RIVER HILLS DRIVE", "city": "CINCINNATI", "state": "OH", "zip": "45244"}, "former-company": {"former-conformed-name": "MERIDIAN DIAGNOSTICS INC", "date-changed": "19920703"}}
Form S-8 Registration Statement
As filed with the Securities and Exchange Commission on December 17, 2001
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Incorporated
Under the Laws
of Ohio
MERIDIAN BIOSCIENCE, INC.
3471 River Hills Drive
CINCINNATI, OHIO  45244
I.R.S. Employer
Identification No.
31-0888197
1999 DIRECTORS' STOCK OPTION PLAN
AMENDED AND RESTATED 1996 STOCK OPTION PLAN
Robert E. Coletti, Esq.
Keating, Muething & Klekamp, P.L.L.
One East Fourth Street
Cincinnati, Ohio 45202
(513) 579-6560
(Agent for Service)
CALCULATION
OF REGISTRATION FEE
Title of
Securities
To Be Registered
Common Stock,
No par value
Amount
To Be
Registered(1)
500,000 Shares
Proposed
Maximum
Offering
Price
Per Share(2)
$5.86
Proposed
Maximum
Aggregate
Offering
Price(2)
$1,800,000
Amount of
Registration
Fee(3)
$733
(1)
This Registration Statement is filed for up to an additional 500,000 shares
issuable upon the exercise of options granted pursuant to the Meridian
Bioscience, Inc. Amended and Restated 1996 Stock Option Plan. This Registration
Statement does not cover any additional shares issuable upon the exercise of
options granted pursuant to the 1999 Directors' Stock Option Plan.
(2)
Estimated solely for purposes of calculating registration fee.
(3)
Calculated pursuant to Rule 457(h) based on the average of the high and low
prices of the Common Stock on the Nasdaq Stock Market on December 11, 2001 at
$5.86 per share.
The  contents of Registration No. 333-74825, as
filed  with the  Commission  on March  22,  1999,  are  incorporated  herein  by
reference.
Item 8.      Exhibits*
4.1
Meridian  Bioscience,  Inc. 1999 Directors'  Stock Option Plan  (incorporated by
reference  to  Meridian's  Definitive  Proxy  Statement  filed  with  the SEC on
December 21, 1998)
4.2
Meridian   Bioscience,   Inc.  Amended  and  Restated  1996  Stock  Option  Plan
(incorporated  by reference to Meridian's  Definitive Proxy Statement filed with
the SEC on December 21, 1998)
5
Opinion of Keating, Muething & Klekamp, P.L.L.
23.1
Consent  of  Arthur Andersen LLP
23.2
Consent  of  Keating,  Muething  &  Klekamp,  PLL  (contained  on
               Exhibit 5).
24
Power of Attorney (contained in the
signature page).
*All exhibits are filed herewith unless otherwise indicated.
SIGNATURES
Pursuant  to the requirements of the Securities
Act of 1933, the registrant  certifies that it has reasonable grounds to believe
that it meets all of the requirements for filing on Form S-8 and has duly caused
this  Registration  Statement  to be  signed on its  behalf by the  undersigned,
thereunto duly authorized, in Cincinnati, Ohio, on December 14, 2001.
MERIDIAN BIOSCIENCE, INC.
By:
/s/ William J. Motto
William J. Motto
Chairman of the Board and
Chief Executive Officer
Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated. Each person whose signature appears below
marked with an asterisk hereby authorizes  William J. Motto and Melissa A. Lueke
as attorneys-in-fact
to sign on his/her behalf  individually  and in each capacity  indicated  below, any
amendments,   including   post-effective   amendments,   to  this   Registration
Statement.
Signature
*/s/William J. Motto
William J. Motto
*/s/John A. Kraeutler
John A. Kraeutler
*/s/Melissa A. Lueke
Melissa A. Lueke
*/s/James A. Buzard
James A. Buzard
*/s/Gary P. Kreider
Gary P. Kreider
*/s/David C. Phillips
David C. Phillips
*/s/Robert J. Ready
Robert J. Ready
Capacity
Chairman of the Board
and Chief Executive Officer
(Principal Executive Officer)
President, Chief Operating
Officer and Director
Vice President, Secretary and
Chief Financial Officer
(Principal Financial Officer
and Principal Accounting
Officer
Director
Director
Director
Director
Date
December 14, 2001
December 14, 2001
December 14, 2001
December 14, 2001
December 14, 2001
December 14, 2001
December 14, 2001