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<TITLE>Genentech, Inc. Form S-8  5-2-02</TITLE>
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        <TD valign="top"><FONT size="2">As filed with the Securities and Exchange Commission on May&nbsp;2, 2002</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
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Registration No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
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<P align="center"><FONT size="4"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B></FONT>

<DIV align="center"><FONT size="2"><B>Washington, D.C. 20549</B></FONT></DIV>

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<P align="center"><FONT size="5"><B>FORM S-8</B></FONT>

<DIV align="center"><FONT size="2">REGISTRATION STATEMENT UNDER<BR>
THE SECURITIES ACT OF 1933, AS AMENDED</FONT></DIV>

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<P align="center"><FONT size="4"><B>Genentech, Inc.</B></FONT>

<DIV align="center"><FONT size="1">(Exact name of registrant as specified in its charter)</FONT></DIV>






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        <TD align="center" valign="top"><FONT size="3">Delaware</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="3">
94-2345624</FONT></TD>
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        <TD valign="top" align="center"><FONT size="1">(State of Incorporation)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="1">(I.R.S. Employer Identification No.)</FONT></TD>
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        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="3">1 DNA Way<BR>
South San Francisco,<BR>
California</FONT></TD>
        <TD><FONT size="3">&nbsp;</FONT></TD>
        <TD align="center" valign="bottom"><FONT size="3">
94080-4990</FONT></TD>
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        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="1">(Address of principal executive offices)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="1">(Zip Code)</FONT></TD>
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<P align="center"><FONT size="2"><B>Genentech, Inc.<BR>
1999 Stock Plan, as amended and restated on 12/8/00</B></FONT>

<DIV align="center"><FONT size="1">(Full titles of the plans)</FONT></DIV>

<P align="center"><FONT size="2"><B>Stephen G. Juelsgaard, Esq.<BR>
Senior Vice President, General Counsel and Secretary<BR>
Genentech, Inc.<BR>
1 DNA Way<BR>
South San Francisco, California 94080-4990</B></FONT>

<DIV align="center"><FONT size="1">(Name and address of agent for service)</FONT></DIV>

<P align="center"><FONT size="2">(650)&nbsp;225-1000</FONT>

<DIV align="center"><FONT size="1">(Telephone number, including area code, of agent for service)</FONT></DIV>


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<TR><TD align="center" colspan="9"><FONT size="2"><B>CALCULATION OF REGISTRATION
FEE</B></FONT></TD></TR>

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        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
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        <TD nowrap align="center"><FONT size="1"><B>Title of Securities</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Amount to be</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Offering</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Aggregate</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Amount of</B></FONT></TD>
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        <TD nowrap align="center"><FONT size="1"><B>to be Registered</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Registered</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Price per Share(1)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Offering Price(1)</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Registration Fee</B></FONT></TD>
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        <TD valign="top"><FONT size="2">Common stock, par value
$.02 per share(2)</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="center" valign="top"><FONT size="2">
15,000,000&nbsp;shares</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="center" valign="top"><FONT size="2">$35.30
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="center" valign="top"><FONT size="2">$529,500,000.00
</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="center" valign="top"><FONT size="2">$48,714.00</FONT></TD>
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      <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2">Estimated pursuant to Rule&nbsp;457(c) promulgated under the Securities
Act of 1933, as amended, with reference to the high and low prices on
April&nbsp;30, 2002, reported on the New York Stock Exchange of $36.10 and
$34.50, respectively, the average of which is $35.30.</FONT></TD>
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<P align="center"><FONT size="2">&nbsp;
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<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

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<TR><TD></TD><TD colspan="8"><A HREF="#000">PART II: INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">Item 3: Incorporation of Documents by Reference</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#002">Item 4: Description of Securities</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#003">Item 5: Interests of Named Experts and Counsel</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#004">Item 6: Indemnification of Directors and Officers</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#005">Item 7: Exemption from Registration Claimed</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#006">Item 8: Exhibits</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#007">Item 9: Undertakings</A></TD></TR>
<TR><TD colspan="9"><A HREF="#008">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#009">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="f81260ex5.txt">EXHIBIT 5</A></TD></TR>
<TR><TD colspan="9"><A HREF="f81260ex15-1.txt">EXHIBIT 15.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="f81260ex23-1.txt">EXHIBIT 23.1</A></TD></TR>
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<!-- link2 "PART II: INFORMATION REQUIRED IN THE REGISTRATION STATEMENT" -->
<DIV align="left"><A NAME="000"></A></DIV>
<P align="left"><FONT size="2"><B>PART&nbsp;II:&nbsp;&nbsp;&nbsp;INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B></FONT>

<!-- link2 "Item 3: Incorporation of Documents by Reference" -->
<DIV align="left"><A NAME="001"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;3:&nbsp;&nbsp;&nbsp;Incorporation of Documents by Reference</B></FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In this Registration Statement, &#147;Genentech,&#148; &#147;we,&#148; &#147;us&#148; and &#147;our&#148; refer to
Genentech, Inc. The Securities and Exchange Commission, or SEC, allows us to
&#147;incorporate by reference&#148; the information we file with it, which means we can
disclose important information by referring to those documents. The
information included in the following documents is incorporated by reference
and is considered to be a part of this Registration Statement. The most recent
information that we file with the SEC automatically updates and supersedes more
dated information. We have previously filed the following documents with the
SEC and incorporate them by reference into this Registration Statement:
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;&nbsp;Our annual report on Form&nbsp;10-K for the year ended December&nbsp;31, 2001;
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&nbsp;&nbsp;Our quarterly report on Form&nbsp;10-Q for the quarter ended March&nbsp;31,
2002; and
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;&nbsp;&nbsp;&nbsp;The description under the heading &#147;Description of Capital Stock&#148;
relating to our common stock in the prospectus included in our Amendment No.&nbsp;2
to the Registration Statement on Form&nbsp;S-3 (Registration No.&nbsp;333-88651) filed
with the SEC on October&nbsp;20, 1999, and the description under the heading
&#147;Description of Capital Stock&#148; relating to the common stock in the our final
prospectus filed with the SEC on October&nbsp;21, 1999 pursuant to Rule&nbsp;424(b) under
the Securities Act of 1933, as amended, which is commonly known as the
Securities Act, including any amendment or report filed for the purpose of
updating that description.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; We also incorporate by reference all documents subsequently filed by us
pursuant to Section&nbsp;13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of
1934, as amended, which is commonly known as the Exchange Act, until all of the
shares registered under this Registration Statement are sold.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We will provide without charge to each person to whom a prospectus is
delivered, including any beneficial owner, a copy of any or all of the
information that has been incorporated by reference in this Registration
Statement. If you would like to obtain this information from us, please direct
your request to the Investor Relations Department, either in writing or by
telephone, to Genentech, Inc., 1 DNA Way, South San Francisco, California
94080, Attention Investor Relations (650)&nbsp;225-1260.
</FONT>
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<DIV align="left"><A NAME="002"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;4:&nbsp;&nbsp;&nbsp;Description of Securities</B></FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
</FONT>
<!-- link2 "Item 5: Interests of Named Experts and Counsel" -->
<DIV align="left"><A NAME="003"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;5:&nbsp;&nbsp;&nbsp;Interests of Named Experts and Counsel</B></FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Stephen G. Juelsgaard, Senior Vice President, General Counsel and
Secretary of Genentech, is an officer of Genentech and has received options
under our amended and restated 1999 Stock Plan.
</FONT>
<!-- link2 "Item 6: Indemnification of Directors and Officers" -->
<DIV align="left"><A NAME="004"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;6:&nbsp;&nbsp;&nbsp;Indemnification of Directors and Officers</B></FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Our certificate of incorporation limits, to the fullest extent permitted
by Delaware corporate law, the personal liability of directors for monetary
damages for breach of their fiduciary duties.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145 of the General Corporation Law of the State of Delaware (the
&#147;DGCL&#148;) provides, in summary, that directors and officers of Delaware
corporations are entitled, under certain circumstances, to be indemnified
against all expenses and liabilities (including attorneys&#146; fees) incurred by
them as a result of suits brought against them in their capacity as a director
or officer, if they acted in good faith and in a manner they reasonably
believed to be in or not opposed to the best interests of the corporation, and
with respect to any criminal action or proceeding, if they had no reasonable
cause to believe their conduct was unlawful; provided, that no indemnification
may be made against expenses in respect of any claim, issue or matter as to
which they shall have been adjudged to be liable to the corporation, unless and
only to the extent that the court in which such action or suit was brought
shall determine
</FONT>

<P align="center"><FONT size="2">&nbsp;
</FONT>

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<P align="left"><FONT size="2">upon application that, despite the adjudication of liability but in view
of all the circumstances of the case, they are fairly and reasonably entitled
to indemnity for such expenses which the court shall deem proper. Any such
indemnification may be made by the corporation only as authorized in each
specific case upon a determination by the stockholders or disinterested
directors that indemnification is proper because the indemnitee has met the
applicable standard of conduct.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Our board of directors may provide similar indemnification to our
officers, employees and agents as it deems appropriate and as authorized by
Delaware law. We may purchase insurance on behalf of any director, officer,
employee or agent against any expense incurred by such person in his or her
capacity.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Our certificate of incorporation also provides that Roche and the officers
or directors of Roche Holdings, Inc., or Roche, which is our majority
stockholder, will not be presumed liable to us or our stockholders for breach
of any fiduciary duty or duty of loyalty, failure to act in the best interests
of Genentech, or receipt of any improper personal benefit, simply because Roche
or any director or officer of Roche, in good faith, takes any action, exercises
any right or gives or withholds any consent with respect to any agreement or
contract between Roche and Genentech.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In addition, Roche will not be liable to us or our stockholders for breach
of any fiduciary duty if Roche pursues or acquires a potential corporate
opportunity of ours or does not inform us of a potential corporate opportunity.
If a director, officer or employee of Genentech who is also a director, officer
or employee of Roche knows of a potential transaction or matter that may be a
corporate opportunity both for Genentech and Roche, the director, officer or
employee is entitled to offer the corporate opportunity to us or Roche as the
director, officer or employee deems appropriate under the circumstances in his
or her sole discretion, and no such director, officer or employee will be
liable to us or our stockholders for breach of any fiduciary duty or duty of
loyalty or failure to act in our best interests or the derivation of any
improper personal benefit by reason of the fact that such director, officer or
employee offered such corporate opportunity to Roche (rather than to us) or did
not communicate information regarding such corporate opportunity to us, or
Roche pursues or acquires such corporate opportunity for itself or directs such
corporate opportunity to another person or does not communicate the corporate
opportunity to us.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Neither Roche nor any officer or director thereof shall be liable to us or
our stockholders for breach of any fiduciary duty or duty of loyalty or failure
to act in (or not opposed to) our best interests or the derivation of any
improper personal benefit by reason of the fact that Roche or an officer of
director thereof in good faith takes any action or exercises any rights or
gives or withholds any consent in connection with any agreement or contract
between Roche and Genentech. No vote cast or other action taken by any person
who is an officer, director or other representative of Roche, which vote is
cast or action is taken by such person in his capacity as a director of
Genentech, shall constitute an action of or the exercise of a right by or a
consent of Roche for the purpose of any such agreement or contract.
</FONT>
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<P align="left"><FONT size="2"><B>Item&nbsp;7:&nbsp;&nbsp;&nbsp;Exemption from Registration Claimed</B></FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.
</FONT>
<!-- link2 "Item 8: Exhibits" -->
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<P align="left"><FONT size="2"><B>Item&nbsp;8:&nbsp;&nbsp;&nbsp;Exhibits</B></FONT>
<P align="left">
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      <TD width="3%"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
      <TD align="center" width="3%"><FONT size="2"><B>Exhibit<BR>
Number</B></FONT></TD></TR>
<TR><TD><TR><TD><TR><TD><TR><TD>

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        <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center"><FONT size="2">&nbsp;&nbsp;5&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
      <TD width="5%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="89%"><FONT size="2">Opinion of Stephen G. Juelsgaard, Esq.</FONT></TD></TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center"><FONT size="2">10.25</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">Genentech, Inc. 1999 Stock Plan, as amended and restated on 12/8/00. (*)</FONT></TD></TR>
<TR><TD>&nbsp;</TD></TR>

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        <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center"><FONT size="2">15.1&nbsp;&nbsp;</FONT></TD>
      <TD width="5%"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
      <TD width="89%"><FONT size="2">Letter re: Unaudited Interim Financial Information.</FONT></TD></TR>
<TR><TD>&nbsp;</TD></TR>

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        <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center"><FONT size="2">23.1&nbsp;&nbsp;</FONT></TD>
      <TD width="5%"><FONT size="2">&nbsp;</FONT></TD>
      <TD width="89%"><FONT size="2">Consent of Ernst &#038; Young LLP, independent auditors.</FONT></TD></TR>
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<P align="center"><FONT size="2">&nbsp;
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        <TD width="3%"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
      <TD width="3%" align="center"><FONT size="2">&nbsp;&nbsp;&nbsp;23.2&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
      <TD width="5%"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
      <TD width="89%"><FONT size="2">Consent of Stephen G. Juelsgaard, Esq. is contained in Exhibit&nbsp;5 to this Registration Statement.
</FONT>
<TR><TD>&nbsp;</TD></TR>

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        <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD align="center"><FONT size="2">24&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
      <TD><FONT size="2">&nbsp;</FONT></TD>
      <TD><FONT size="2">Power of Attorney is contained in the signature pages.
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      <TD width="1%" align="left" nowrap><FONT size="2">(*)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;&nbsp;&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2"> Previously filed as Exhibit&nbsp;10.25 to our Annual Report on 10-K for the year ended December&nbsp;31, 2000.</FONT></TD>
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<!-- link2 "Item 9: Undertakings" -->
<DIV align="left"><A NAME="007"></A></DIV>
<P align="left"><FONT size="2"><B>Item&nbsp;9:&nbsp;&nbsp;&nbsp;Undertakings</B></FONT>

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   <TD width="1%" align="right" nowrap><FONT size="2"><B>1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></TD>
   <TD width="1%" colspan="3"><FONT size="2">The undersigned registrant hereby undertakes:</FONT></TD>
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<TR><TD>&nbsp;</TD></TR>

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        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD width="1%"><FONT size="2"><B>(a)&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></TD>
   <TD width="1%" colspan="2"><FONT size="2">To file, during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

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        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD width="1%"><FONT size="2"><B>(i)</B></FONT></TD>
   <TD width="97%"><FONT size="2">To include any prospectus required by section
10(a)(3) of the Securities Act;</FONT></TD>
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<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2"><B>(ii)</B></FONT></TD>
   <TD><FONT size="2">To reflect in the prospectus any facts or events
arising after the effective date of the registration statement
(or the most recent post-effective amendment thereof) which,
individually or in the aggregate, represent a fundamental
change in the information set forth in the registration
statement. Notwithstanding the foregoing, any increase or
decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was
registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form
of prospectus filed with the SEC pursuant to Rule&nbsp;424(b) if,
in the aggregate, the changes in volume and price represent no
more than a 20% change in the maximum aggregate offering price
set forth in the &#147;Calculation of Registration Fee&#148; table in
the effective registration statement.</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD><FONT size="2"><B>(iii)&nbsp;&nbsp;&nbsp;</B></FONT></TD>
   <TD><FONT size="2">To include any material information with respect
to the plan of distribution not previously disclosed in the
registration statement or any material change to such
information in the registration statement;</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="2"><FONT size="2"><I>Provided, however, </I>that paragraphs (a)(i) and (a)(ii) do not apply
if the information required to be included in a post-effective
amendment by those paragraphs is contained in periodic reports
filed by the issuer pursuant to section 13 or section 15(d) of the
Exchange Act that are incorporated by reference herein.</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD width="1%"><FONT size="2"><B>(b)&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></TD>
   <TD width="1%" colspan="2"><FONT size="2">That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities
offered herein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;</FONT></TD>
        <TD width="1%"><FONT size="2"><B>(c)&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></TD>
   <TD width="1%" colspan="2"><FONT size="2">To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold
at the termination of the offering.</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
   <TD><FONT size="2"><B>2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></TD>
   <TD colspan="3"><FONT size="2">The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant&#146;s annual report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of
the Exchange Act (and, where applicable, each filing of an employee
benefit plan&#146;s annual report pursuant to section 15(d) of the Exchange
Act) that is incorporated by reference in the Registration Statement shall
be deemed to be a new registration statement relating to the securities
offered herein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
   <TD><FONT size="2"><B>3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></TD>
   <TD colspan="3"><FONT size="2">Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the SEC such
indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">&nbsp;
</FONT>

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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<P align="left">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
   <TD width="1%" align="right" nowrap><FONT size="2">&nbsp;</FONT></TD>
   <TD width="1%" nowrap><FONT size="2">&nbsp;&nbsp;</FONT></TD>
   <TD width="97%"><FONT size="2">indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or
controlling person of the registrant in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered,
the registrant will, unless in the opinion of its counsel the matter has
been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against
public policy as expressed in the Securities Act and will be governed by
the final adjudication of such issue.</FONT></TD>
</TR>
</TABLE>
<P align="center"><FONT size="2">&nbsp;
</FONT>

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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>



<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="008"></A></DIV>
<P align="center"><FONT size="2"><B>SIGNATURES</B></FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Pursuant to the requirements of the Securities Act of 1933, as amended,
the undersigned registrant certifies that it has reasonable grounds to believe
that it meets all of the requirements for filing on Form&nbsp;S-8 and has duly
caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of South San Francisco,
State of California, on April&nbsp;26, 2002.
</FONT>

<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
        <TD width="55%">&nbsp;</TD>
        <TD width="1%">&nbsp;</TD>
        <TD width="44%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD colspan="2" align="left" valign="top"><FONT size="2">
<B>GENENTECH, INC</B></FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">By:</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
/s/&nbsp;&nbsp;STEPHEN G. JUELSGAARD</FONT><DIV STYLE="margin-top:-2px; margin-bottom:-2px"><HR size="1" noshade></DIV></TD>
</TR>

<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Name:&nbsp;&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Stephen G. Juelsgaard</FONT></TD>
</TR>

<TR valign="bottom">
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">Title:</FONT></TD>
        <TD align="left" valign="top"><FONT size="2">
Senior Vice President, General Counsel and Secretary</FONT></TD>
</TR>
</TABLE>


<P align="center"><FONT size="2">&nbsp;
</FONT>

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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>

<P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B></FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <B>KNOW ALL PERSONS BY THESE PRESENTS</B>, that each person whose signature
appears below constitutes and appoints Stephen G. Juelsgaard and Roy C.
Hardiman, and each or any one of them, his true and lawful attorney-in-fact and
agent, with full power of substitution and resubstitution, for him and in his
name, place and stead, in any and all capacities, to sign any and all
amendments (including post-effective amendments) to this Registration
Statement, and to file the same, with all exhibits thereto, and other documents
in connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in connection therewith, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that said attorneys-in-fact and agents, or any of them, or their or his
substitutes or substitute, may lawfully do or cause to be done by virtue
hereof.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
</FONT>

<P align="center"><FONT size="2">&nbsp;
</FONT>


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        <TD width="40%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="40%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="10%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
</TR>
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        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="1">&nbsp;</FONT></TD>
        <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR><TD><TR><TD><TR><TD><TR><TD>

<TR valign="top">
        <TD nowrap align="center"><FONT size="2">/s/ ARTHUR D. LEVINSON</FONT>
        <DIV STYLE="margin-top:-2px; margin-bottom:-2px"><HR size="1" noshade></DIV>
        <FONT size="2">Arthur D. Levinson</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">
        Principal Executive Officer and Chairman</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">April 26, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap align="center"><FONT size="2">/s/&nbsp;&nbsp;LOUIS J. LAVIGNE, JR.</FONT>
        <DIV STYLE="margin-top:-2px; margin-bottom:-2px"><HR size="1" noshade></DIV>
        <FONT size="2">Louis J. Lavigne, Jr.</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">Principal Financial Officer</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">April 26, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap align="center"><FONT size="2">/s/&nbsp;&nbsp;JOHN M. WHITING</FONT>
        <DIV STYLE="margin-top:-2px; margin-bottom:-2px"><HR size="1" noshade></DIV>
        <FONT size="2">John M. Whiting</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">Principal Accounting Officer</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">April 26, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap align="center"><FONT size="2">&nbsp;</FONT>
        <DIV STYLE="margin-top:-2px; margin-bottom:-2px"><HR size="1" noshade></DIV>
        <FONT size="2">Herbert W. Boyer</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">Director</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">April 26, 2002</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>
<TR valign="top">
        <TD nowrap align="center"><FONT size="2">/s/&nbsp;&nbsp;FRANZ B. HUMER</FONT>
        <DIV STYLE="margin-top:-2px; margin-bottom:-2px"><HR size="1" noshade></DIV>
        <FONT size="2">Franz B. Humer</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">Director</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">April 26, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap align="center"><FONT size="2">/s/&nbsp;&nbsp;JONATHAN K.C. KNOWLES</FONT>
        <DIV STYLE="margin-top:-2px; margin-bottom:-2px"><HR size="1" noshade></DIV>
        <FONT size="2">Jonathan K.C. Knowles</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">Director</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">April 26, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap align="center"><FONT size="2">/s/&nbsp;&nbsp;CHARLES A. SANDERS</FONT>
        <DIV STYLE="margin-top:-2px; margin-bottom:-2px"><HR size="1" noshade></DIV>
        <FONT size="2">Charles A. Sanders</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">Director</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">April 26, 2002</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap align="center"><FONT size="2">/s/&nbsp;&nbsp;MARK RICHMOND</FONT>
        <DIV STYLE="margin-top:-2px; margin-bottom:-2px"><HR size="1" noshade></DIV>
        <FONT size="2">Mark Richmond</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">Director</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><FONT size="2">April 26, 2002</FONT></TD>
</TR>
</TABLE>

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<!-- link1 "EXHIBIT INDEX" -->
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<P align="center"><FONT size="2"><B>EXHIBIT INDEX</B></FONT>

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<TR valign="bottom">
        <TD width="3%">&nbsp;</TD>
        <TD width="5%">&nbsp;</TD>
        <TD width="92%">&nbsp;</TD>
</TR>
<TR valign="bottom">
        <TD nowrap align="center"><FONT size="1"><B>Exhibit<BR>
Number</B></FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="center"><FONT size="1"><B>Description</B></FONT></TD>
</TR>
<TR valign="middle">
        <TD nowrap align="center"><HR size="1" noshade></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD nowrap align="left"><HR size="1" noshade></TD>
</TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;5</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left"><FONT size="2">Opinion of Stephen G. Juelsgaard, Esq.</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;&nbsp;10.25</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left"><FONT size="2">Genentech, Inc. 1999 Stock Plan, as amended and restated on 12/8/00. (*)
</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;&nbsp;15.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left"><FONT size="2">Letter re: Unaudited Interim Financial Information.
</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;&nbsp;23.1</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left"><FONT size="2">Consent of Ernst &#038; Young LLP, independent auditors.
</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;&nbsp;23.2</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left"><FONT size="2">Consent of Stephen G. Juelsgaard, Esq. is contained in Exhibit&nbsp;5 to this Registration Statement.
</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
        <TD nowrap><FONT size="2">&nbsp;&nbsp;24</FONT></TD>
        <TD><FONT size="2">&nbsp;</FONT></TD>
        <TD align="left"><FONT size="2">Power of Attorney is contained on the signature page.
</FONT></TD>
</TR>
</TABLE>


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      <TD width="1%" align="left" nowrap><FONT size="2">(*)</FONT></TD>
        <TD width="3%"><FONT size="2">&nbsp;&nbsp;&nbsp;</FONT></TD>
        <TD width="96%"><FONT size="2"> Previously filed as Exhibit&nbsp;10.25 to our Annual Report on 10-K for the year ended December&nbsp;31, 2000.</FONT></TD>
</TR>
</TABLE>

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</BODY>
</HTML>
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Genentech, Inc. Form S-8  5-2-02
Table of Contents
As filed with the Securities and Exchange Commission on May 2, 2002
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER
THE SECURITIES ACT OF 1933, AS AMENDED
Genentech, Inc.
(Exact name of registrant as specified in its charter)
Delaware
94-2345624
(State of Incorporation)
(I.R.S. Employer Identification No.)
1 DNA Way
South San Francisco,
California
94080-4990
(Address of principal executive offices)
(Zip Code)
Genentech, Inc.
1999 Stock Plan, as amended and restated on 12/8/00
(Full titles of the plans)
Stephen G. Juelsgaard, Esq.
Senior Vice President, General Counsel and Secretary
Genentech, Inc.
1 DNA Way
South San Francisco, California 94080-4990
(Name and address of agent for service)
(650) 225-1000
(Telephone number, including area code, of agent for service)
CALCULATION OF REGISTRATION
FEE
Proposed Maximum
Proposed Maximum
Title of Securities
Amount to be
Offering
Aggregate
Amount of
to be Registered
Registered
Price per Share(1)
Offering Price(1)
Registration Fee
Common stock, par value
$.02 per share(2)
15,000,000 shares
$35.30
$529,500,000.00
$48,714.00
(1)
Estimated pursuant to Rule 457(c) promulgated under the Securities
Act of 1933, as amended, with reference to the high and low prices on
April 30, 2002, reported on the New York Stock Exchange of $36.10 and
$34.50, respectively, the average of which is $35.30.
TABLE OF CONTENTS
PART II: INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3: Incorporation of Documents by Reference
Item 4: Description of Securities
Item 5: Interests of Named Experts and Counsel
Item 6: Indemnification of Directors and Officers
Item 7: Exemption from Registration Claimed
Item 8: Exhibits
Item 9: Undertakings
SIGNATURES
EXHIBIT INDEX
EXHIBIT 5
EXHIBIT 15.1
EXHIBIT 23.1
Table of Contents
PART II:   INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3:   Incorporation of Documents by Reference
In this Registration Statement, "Genentech," "we," "us" and "our" refer to
Genentech, Inc. The Securities and Exchange Commission, or SEC, allows us to
"incorporate by reference" the information we file with it, which means we can
disclose important information by referring to those documents. The
information included in the following documents is incorporated by reference
and is considered to be a part of this Registration Statement. The most recent
information that we file with the SEC automatically updates and supersedes more
dated information. We have previously filed the following documents with the
SEC and incorporate them by reference into this Registration Statement:
(a)    Our annual report on Form 10-K for the year ended December 31, 2001;
(b)    Our quarterly report on Form 10-Q for the quarter ended March 31,
2002; and
(c)    The description under the heading "Description of Capital Stock"
relating to our common stock in the prospectus included in our Amendment No. 2
to the Registration Statement on Form S-3 (Registration No. 333-88651) filed
with the SEC on October 20, 1999, and the description under the heading
"Description of Capital Stock" relating to the common stock in the our final
prospectus filed with the SEC on October 21, 1999 pursuant to Rule 424(b) under
the Securities Act of 1933, as amended, which is commonly known as the
Securities Act, including any amendment or report filed for the purpose of
updating that description.
We also incorporate by reference all documents subsequently filed by us
pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of
1934, as amended, which is commonly known as the Exchange Act, until all of the
shares registered under this Registration Statement are sold.
We will provide without charge to each person to whom a prospectus is
delivered, including any beneficial owner, a copy of any or all of the
information that has been incorporated by reference in this Registration
Statement. If you would like to obtain this information from us, please direct
your request to the Investor Relations Department, either in writing or by
telephone, to Genentech, Inc., 1 DNA Way, South San Francisco, California
94080, Attention Investor Relations (650) 225-1260.
Item 4:   Description of Securities
Not applicable.
Item 5:   Interests of Named Experts and Counsel
Stephen G. Juelsgaard, Senior Vice President, General Counsel and
Secretary of Genentech, is an officer of Genentech and has received options
under our amended and restated 1999 Stock Plan.
Item 6:   Indemnification of Directors and Officers
Our certificate of incorporation limits, to the fullest extent permitted
by Delaware corporate law, the personal liability of directors for monetary
damages for breach of their fiduciary duties.
Section 145 of the General Corporation Law of the State of Delaware (the
"DGCL") provides, in summary, that directors and officers of Delaware
corporations are entitled, under certain circumstances, to be indemnified
against all expenses and liabilities (including attorneys' fees) incurred by
them as a result of suits brought against them in their capacity as a director
or officer, if they acted in good faith and in a manner they reasonably
believed to be in or not opposed to the best interests of the corporation, and
with respect to any criminal action or proceeding, if they had no reasonable
cause to believe their conduct was unlawful; provided, that no indemnification
may be made against expenses in respect of any claim, issue or matter as to
which they shall have been adjudged to be liable to the corporation, unless and
only to the extent that the court in which such action or suit was brought
shall determine
Table of Contents
upon application that, despite the adjudication of liability but in view
of all the circumstances of the case, they are fairly and reasonably entitled
to indemnity for such expenses which the court shall deem proper. Any such
indemnification may be made by the corporation only as authorized in each
specific case upon a determination by the stockholders or disinterested
directors that indemnification is proper because the indemnitee has met the
applicable standard of conduct.
Our board of directors may provide similar indemnification to our
officers, employees and agents as it deems appropriate and as authorized by
Delaware law. We may purchase insurance on behalf of any director, officer,
employee or agent against any expense incurred by such person in his or her
capacity.
Our certificate of incorporation also provides that Roche and the officers
or directors of Roche Holdings, Inc., or Roche, which is our majority
stockholder, will not be presumed liable to us or our stockholders for breach
of any fiduciary duty or duty of loyalty, failure to act in the best interests
of Genentech, or receipt of any improper personal benefit, simply because Roche
or any director or officer of Roche, in good faith, takes any action, exercises
any right or gives or withholds any consent with respect to any agreement or
contract between Roche and Genentech.
In addition, Roche will not be liable to us or our stockholders for breach
of any fiduciary duty if Roche pursues or acquires a potential corporate
opportunity of ours or does not inform us of a potential corporate opportunity.
If a director, officer or employee of Genentech who is also a director, officer
or employee of Roche knows of a potential transaction or matter that may be a
corporate opportunity both for Genentech and Roche, the director, officer or
employee is entitled to offer the corporate opportunity to us or Roche as the
director, officer or employee deems appropriate under the circumstances in his
or her sole discretion, and no such director, officer or employee will be
liable to us or our stockholders for breach of any fiduciary duty or duty of
loyalty or failure to act in our best interests or the derivation of any
improper personal benefit by reason of the fact that such director, officer or
employee offered such corporate opportunity to Roche (rather than to us) or did
not communicate information regarding such corporate opportunity to us, or
Roche pursues or acquires such corporate opportunity for itself or directs such
corporate opportunity to another person or does not communicate the corporate
opportunity to us.
Neither Roche nor any officer or director thereof shall be liable to us or
our stockholders for breach of any fiduciary duty or duty of loyalty or failure
to act in (or not opposed to) our best interests or the derivation of any
improper personal benefit by reason of the fact that Roche or an officer of
director thereof in good faith takes any action or exercises any rights or
gives or withholds any consent in connection with any agreement or contract
between Roche and Genentech. No vote cast or other action taken by any person
who is an officer, director or other representative of Roche, which vote is
cast or action is taken by such person in his capacity as a director of
Genentech, shall constitute an action of or the exercise of a right by or a
consent of Roche for the purpose of any such agreement or contract.
Item 7:   Exemption from Registration Claimed
Not applicable.
Item 8:   Exhibits
Exhibit
Number
5
Opinion of Stephen G. Juelsgaard, Esq.
10.25
Genentech, Inc. 1999 Stock Plan, as amended and restated on 12/8/00. (*)
15.1
Letter re: Unaudited Interim Financial Information.
23.1
Consent of Ernst & Young LLP, independent auditors.
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23.2
Consent of Stephen G. Juelsgaard, Esq. is contained in Exhibit 5 to this Registration Statement.
24
Power of Attorney is contained in the signature pages.
(*)
Previously filed as Exhibit 10.25 to our Annual Report on 10-K for the year ended December 31, 2000.
Item 9:   Undertakings
1.
The undersigned registrant hereby undertakes:
(a)
To file, during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:
(i)
To include any prospectus required by section
10(a)(3) of the Securities Act;
(ii)
To reflect in the prospectus any facts or events
arising after the effective date of the registration statement
(or the most recent post-effective amendment thereof) which,
individually or in the aggregate, represent a fundamental
change in the information set forth in the registration
statement. Notwithstanding the foregoing, any increase or
decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was
registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form
of prospectus filed with the SEC pursuant to Rule 424(b) if,
in the aggregate, the changes in volume and price represent no
more than a 20% change in the maximum aggregate offering price
set forth in the "Calculation of Registration Fee" table in
the effective registration statement.
(iii)
To include any material information with respect
to the plan of distribution not previously disclosed in the
registration statement or any material change to such
information in the registration statement;
Provided, however,
that paragraphs (a)(i) and (a)(ii) do not apply
if the information required to be included in a post-effective
amendment by those paragraphs is contained in periodic reports
filed by the issuer pursuant to section 13 or section 15(d) of the
Exchange Act that are incorporated by reference herein.
(b)
That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities
offered herein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.
(c)
To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold
at the termination of the offering.
2.
The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of
the Exchange Act (and, where applicable, each filing of an employee
benefit plan's annual report pursuant to section 15(d) of the Exchange
Act) that is incorporated by reference in the Registration Statement shall
be deemed to be a new registration statement relating to the securities
offered herein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.
3.
Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the SEC such
indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for
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indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or
controlling person of the registrant in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered,
the registrant will, unless in the opinion of its counsel the matter has
been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against
public policy as expressed in the Securities Act and will be governed by
the final adjudication of such issue.
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SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the undersigned registrant certifies that it has reasonable grounds to believe
that it meets all of the requirements for filing on Form S-8 and has duly
caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of South San Francisco,
State of California, on April 26, 2002.
GENENTECH, INC
By:
/s/  STEPHEN G. JUELSGAARD
Name:
Stephen G. Juelsgaard
Title:
Senior Vice President, General Counsel and Secretary
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POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS
, that each person whose signature
appears below constitutes and appoints Stephen G. Juelsgaard and Roy C.
Hardiman, and each or any one of them, his true and lawful attorney-in-fact and
agent, with full power of substitution and resubstitution, for him and in his
name, place and stead, in any and all capacities, to sign any and all
amendments (including post-effective amendments) to this Registration
Statement, and to file the same, with all exhibits thereto, and other documents
in connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in connection therewith, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that said attorneys-in-fact and agents, or any of them, or their or his
substitutes or substitute, may lawfully do or cause to be done by virtue
hereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
Signature
Title
Date
/s/ ARTHUR D. LEVINSON
Arthur D. Levinson
Principal Executive Officer and Chairman
April 26, 2002
/s/  LOUIS J. LAVIGNE, JR.
Louis J. Lavigne, Jr.
Principal Financial Officer
April 26, 2002
/s/  JOHN M. WHITING
John M. Whiting
Principal Accounting Officer
April 26, 2002
Herbert W. Boyer
Director
April 26, 2002
/s/  FRANZ B. HUMER
Franz B. Humer
Director
April 26, 2002
/s/  JONATHAN K.C. KNOWLES
Jonathan K.C. Knowles
Director
April 26, 2002
/s/  CHARLES A. SANDERS
Charles A. Sanders
Director
April 26, 2002
/s/  MARK RICHMOND
Mark Richmond
Director
April 26, 2002
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EXHIBIT INDEX
Exhibit
Number
Description
5
Opinion of Stephen G. Juelsgaard, Esq.
10.25
Genentech, Inc. 1999 Stock Plan, as amended and restated on 12/8/00. (*)
15.1
Letter re: Unaudited Interim Financial Information.
23.1
Consent of Ernst & Young LLP, independent auditors.
23.2
Consent of Stephen G. Juelsgaard, Esq. is contained in Exhibit 5 to this Registration Statement.
24
Power of Attorney is contained on the signature page.
(*)
Previously filed as Exhibit 10.25 to our Annual Report on 10-K for the year ended December 31, 2000.