<HTML>
<HEAD>
<TITLE>sv8</TITLE>
</HEAD>
<BODY bgcolor="#FFFFFF">
<!-- PAGEBREAK -->
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>
<DIV style="font-family: 'Times New Roman',Times,serif">








<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="48%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="50%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top" nowrap><DIV style="margin-left:0px; text-indent:-0px"><B>As filed with the Securities and Exchange Commission on June 20, 2005.</B>
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="right" valign="top"><B>Registration No.&nbsp;333-</B></TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>

<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>





<P align="center" style="font-size: 14pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B>

<DIV align="center" style="font-size: 12pt"><B>Washington, D.C. 20549</B>
</DIV>

<P align="center" style="font-size: 18pt"><B>FORM S-8</B>

<DIV align="center" style="font-size: 12pt"><B>REGISTRATION STATEMENT</B></DIV>


<DIV align="center" style="font-size: 12pt"><B>UNDER</B></DIV>


<DIV align="center" style="font-size: 12pt"><B>THE SECURITIES ACT OF 1933</B></DIV>


<P align="center" style="font-size: 24pt"><B>CONNETICS CORPORATION</B>


<DIV align="center" style="font-size: 10pt"><B>(Exact name of registrant as specified in its charter)</B></DIV>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="47%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD align="center" valign="top"><B>Delaware</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top"><B>94-3173928</B></TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">(State or other jurisdiction
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(I.R.S. Employer</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">of incorporation or organization)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Identification Number)</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><B>3160 Porter Drive<BR>
Palo Alto, California 94304</B>



<P align="center" style="font-size: 10pt">(Address of principal executive offices) (zip code)



<P align="center" style="font-size: 10pt"><B>1995 Employee Stock Purchase Plan<BR>
Stock Plan (2000)<BR>
( </B>Full Title of the Plans <B>)</B>



<P align="center" style="font-size: 10pt"><B>Thomas G. Wiggans<BR>
Chief Executive Officer<BR>
CONNETICS CORPORATION<BR>
3160 Porter Drive<BR>
Palo Alto, California 94304<BR>
(650)&nbsp;843-2800</B><BR>
(Name, address, and telephone number, including area code, of agent for service)














<P align="center" style="font-size: 10pt"><B>CALCULATION OF REGISTRATION FEE</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="35%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="12%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="12%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD style="border-bottom:3px double #000000" colspan="25">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 0px solid #000000">Title of Securities to be</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>

    <TD colspan="3" nowrap align="center" style="border-bottom: 0px solid #000000">Amount to be</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Proposed Maximum Offering</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Proposed Maximum Aggregate</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3">Amount of</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="center" style="border-bottom: 0px solid #000000">Registered (1)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3" style="border-bottom: 0px solid #000000">Registered (2)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3" style="border-bottom: 0px solid #000000">Price per Share (3)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3" style="border-bottom: 0px solid #000000">Offering Price (3)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="3" style="border-bottom: 0px solid #000000">Registration Fee</TD>
</TR>
<TR valign="bottom" style="font-size: 1pt"><!-- Blank Space -->
    <TD style="border-bottom: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
        <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom" style="font-size: 10pt">
    <TD><DIV style="margin-left:15px; text-indent:-15px">Common Stock, $0.001 par value, to be issued
under:</DIV></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom" style="font-size: 1pt"><!-- Blank Space -->
    <TD style="border-bottom: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">1995 Employee Stock Purchase Plan</DIV></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD colspan="2" align="right" nowrap>179,158 shares</TD>
<TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">16.34 </TD>
    <TD nowrap>(4)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">2,927,441.72 </TD>
    <TD nowrap>(4)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">344.56 </TD>
    <TD nowrap>(4)</TD>
</TR>
<TR valign="bottom" style="font-size: 1pt"><!-- Blank Space -->
    <TD style="border-bottom: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">Stock Plan (2000)</DIV></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom" style="font-size: 1pt"><!-- Blank Space -->
    <TD style="border-bottom: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:45px; text-indent:-15px">Issuable Upon Exercise of Outstanding Stock Options</DIV></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD colspan="2" align="right" nowrap>1,014,360 shares</TD>
<TD>&nbsp;</TD>

    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">23.88 </TD>
    <TD nowrap>(5)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">24,222,916.80 </TD>
    <TD nowrap>(5)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">2,851.04 </TD>
    <TD nowrap>(5)</TD>
</TR>


<TR valign="bottom" style="font-size: 1pt"><!-- Blank Space -->
    <TD style="border-bottom: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:45px; text-indent:-15px">Reserved for Future Grants</DIV></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD colspan="2" align="right" nowrap>60,996 shares</TD>
<TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">16.34 </TD>
    <TD nowrap>(4)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">996,674.64 </TD>
    <TD nowrap>(4)</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD nowrap align="right">$</TD>
    <TD align="right">117.31 </TD>
    <TD nowrap>(4)</TD>
</TR>
<TR valign="bottom" style="font-size: 1pt"><!-- Blank Space -->
    <TD style="border-bottom: 1px solid #000000"><DIV style="margin-left:15px; text-indent:-15px">&nbsp;</DIV></TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
    <TD style="border-right: 1px solid #000000; border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
<TD style="border-bottom: 1px solid #000000">&nbsp;</TD>
</TR>

<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">TOTAL</DIV></TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD colspan="2" align="right" nowrap>1,254,514 shares</TD>
<TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">28,147,033.16</TD>
    <TD>&nbsp;</TD>
    <TD style="border-right: 1px solid #000000">&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD align="right">$</TD>
    <TD align="right">3,312.91</TD>
    <TD>&nbsp;</TD>
</TR>
<TR valign="bottom" style="font-size: 1pt">
    <TD style="border-bottom:3px double #000000" colspan="25">&nbsp;</TD>

</TR>

<!-- End Table Body -->
</TABLE>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top">
    <TD width="3%" nowrap align="left">(1)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Each share of common stock being registered pursuant to this Registration Statement includes a
right to purchase one one-thousandth of a share of Series&nbsp;B Participating Preferred Stock pursuant
to an Amended and Restated Rights Agreement between the Registrant and EquiServe Trust Company,
N.A., as Rights Agent.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(2)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">This Registration Statement shall also cover any additional shares of common stock which
become issuable under any of the referenced plans being registered pursuant to this Registration
Statement by reason of any stock dividend, stock split, recapitalization or any other similar
transaction effected without the Registrant&#146;s receipt of consideration, which results in an
increase in the number of the Registrant&#146;s outstanding shares of common stock.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(3)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Estimated solely for the purpose of determining the registration fee.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(4)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Computed in accordance with Rule 457(h) and Rule&nbsp;457 (c)&nbsp;of the Securities Act of 1933, based
on the average the high and low prices of the Registrant&#146;s common stock as reported on The Nasdaq
National Market on June&nbsp;15, 2005.</TD>
</TR>

<TR><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD width="3%" nowrap align="left">(5)</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="96%">Computed in accordance with Rule 457(h) under the Securities Act of 1933, based on the
weighted average per share exercise price of outstanding options granted under the referenced plan.</TD>
</TR>

</TABLE>



<DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>




<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>

<DIV style="font-family: 'Times New Roman',Times,serif">






<DIV align="left">
<!-- TOC -->
</DIV>
<DIV align="left">
<A name="tocpage"></A>
</DIV>

<P align="center" style="font-size: 10pt"><U><B>TABLE OF CONTENTS </B></U>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="100%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px"><A href="#101">PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</A></DIV></TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:45px; text-indent:-15px"><A href="#102">Item&nbsp;3. Incorporation of Documents by Reference</A></DIV></TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:45px; text-indent:-15px"><A href="#103">Item&nbsp;4. Description of Securities</A></DIV></TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:45px; text-indent:-15px"><A href="#104">Item&nbsp;5. Interests of Named Experts and Counsel</A></DIV></TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:45px; text-indent:-15px"><A href="#105">Item&nbsp;6. Indemnification of Officers and Directors</A></DIV></TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:45px; text-indent:-15px"><A href="#106">Item&nbsp;7. Exemption from Registration Claimed</A></DIV></TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:45px; text-indent:-15px"><A href="#107">Item&nbsp;8. Exhibits</A></DIV></TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:45px; text-indent:-15px"><A href="#108">Item&nbsp;9. Undertakings</A></DIV></TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px"><A href="#109">SIGNATURES</A></DIV></TD>
</TR>
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px"><A href="#110">INDEX TO EXHIBITS</A></DIV></TD>
</TR>
<!-- End Table Body -->
<TR><TD colspan="9"><FONT size="2">&nbsp;<A HREF="f09849exv5w1.htm">EXHIBIT 5.1</A></FONT></TD></TR>
<TR><TD colspan="9"><FONT size="2">&nbsp;<A HREF="f09849exv23w2.htm">EXHIBIT 23.2</A></FONT></TD></TR>
</TABLE>
</DIV>

<DIV align="left">
<!-- /TOC -->
</DIV>

<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">


<P align="center" style="font-size: 10pt"><B>PART I<BR>
INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>The documents containing the information specified in this Part&nbsp;I of </B><B>Form S-8</B><B> will be sent or
given to employees as specified by Rule&nbsp;</B><B>428(b)(1)</B><B> of the Securities and Exchange Commission (the
&#147;SEC&#148;). Such documents need not be filed with the SEC either as part of this Registration
Statement or as prospectuses or prospectus supplements pursuant to Rule&nbsp;424. These documents and
the documents incorporated by reference in this Registration Statement pursuant to Item&nbsp;3 of Part
II of this </B><B>Form S-8</B><B>, taken together, constitute a prospectus that meets the requirements of Section
1</B><B>0(a)</B><B> of the Securities Act of 1933.</B>

<DIV align="left">
<A name="101"></A>
</DIV>

<P align="center" style="font-size: 10pt"><B>PART II<BR>
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>


<DIV align="left">
<A name="102"></A>
</DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;3. Incorporation of Documents by Reference.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents and information filed with the Securities and Exchange Commission (the
&#147;SEC&#148;) by Connetics Corporation (Commission File No.&nbsp;0-27406) are hereby incorporated by reference
into this Registration Statement:


<P align="left" style="font-size: 10pt">Connetics&#146; Annual Report on Form&nbsp;10-K for the fiscal year ended
December&nbsp;31, 2004, filed on March&nbsp;16, 2005 including portions of our
Proxy Statement for our 2005 Annual Meeting of Stockholders to the
extent specifically incorporated by reference therein;



<P align="left" style="font-size: 10pt">Our Quarterly Report on Form&nbsp;10-Q for the quarter ended March&nbsp;31, 2005, filed on May&nbsp;10, 2005



<P align="left" style="font-size: 10pt">Connetics&#146; Current Reports on Form&nbsp;8-K, as follows:



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on June&nbsp;13, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on June&nbsp;9, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on June&nbsp;6, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on May&nbsp;19, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on May&nbsp;18, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on May&nbsp;12, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on May&nbsp;10, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on April&nbsp;26, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on April&nbsp;18, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on April&nbsp;7, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on April&nbsp;1, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on March&nbsp;25, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on March&nbsp;22, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on March&nbsp;18, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on March&nbsp;17, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on March&nbsp;14, 2005



<P align="center" style="font-size: 10pt">&nbsp;
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on February&nbsp;18, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on February&nbsp;1, 2005



<P align="left" style="font-size: 10pt">Our Current Report on Form&nbsp;8-K filed on January&nbsp;28, 2005



<P align="left" style="font-size: 10pt">The description of Connetics&#146; common stock contained in our
Registration Statement on Form&nbsp;8-A dated December&nbsp;8, 1995, and filed
with the SEC on December&nbsp;11, 1995, including any amendments or reports
filed with the SEC for the purpose of updating such description; and



<P align="left" style="font-size: 10pt">The description of Connetics&#146; Preferred Share Purchase Rights
contained in our Registration Statement on Form&nbsp;8-A, dated May&nbsp;20,
1997 and filed with the SEC on May&nbsp;23, 1997, as amended by Amendment
No.&nbsp;1 thereto on Form&nbsp;8-A/A, dated November&nbsp;27, 2001 and filed with
the SEC on November&nbsp;28, 2001, including any amendments or reports
filed with the SEC for the purpose of updating such description.






<P align="center" style="font-size: 10pt">3
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and other documents filed by Connetics pursuant to Section&nbsp;13(a), 13(c), 14 and
15(d) of the Exchange Act, after the date of this Registration Statement and prior to the filing of
a post-effective amendment which indicates that all securities offered hereby have been sold or
which deregisters all securities then remaining unsold, shall be deemed to be incorporated by
reference into this Registration Statement and to be part of this Registration Statement from the
date such documents are filed. In no event, however, will any of the information that we disclose
under Item&nbsp;2.02 or Item&nbsp;7.01 of any Current Report on Form 8-K that we furnish with the SEC be
incorporated by reference into, or otherwise included in, this Registration Statement.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any statement contained in a document incorporated or deemed to be incorporated by reference
in this Registration Statement shall be deemed to be modified or superseded for purposes of this
Registration Statement to the extent that a statement contained in this Registration Statement (or
in any other subsequently filed document which also is or is deemed to be incorporated by reference
herein) modifies or supersedes such statement. Any such statement so modified or superseded shall
not be deemed to constitute a part of this Registration Statement, except as so modified or
superseded.

<DIV align="left">
<A name="103"></A>
</DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;4. Description of Securities.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.

<DIV align="left">
<A name="104"></A>
</DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.

<DIV align="left">
<A name="105"></A>
</DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;6. Indemnification of Directors and Officers.</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(a) of the Delaware General Corporation Law, or DGCL, provides, in general, that a
corporation shall have the power to indemnify any person who was or is a party or is threatened to
be made a party to any threatened, pending or completed action, suit or proceeding, other than an
action by or in the right of the corporation, by reason of the fact that the person is or was a
director or officer of the corporation, against expenses (including attorneys&#146; fees), judgments,
fines and amounts paid in settlement actually and reasonably incurred by the person in connection
with such action, suit or proceeding, if the person acted in good faith and in a manner the person
reasonably believed to be in or not opposed to the best interests of the corporation and if, with
respect to any criminal action or proceeding, the person had no reasonable cause to believe the
person&#146;s conduct was unlawful.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(b) of the DGCL provides, in general, that a corporation shall have the power to
indemnify any person who was or is a party or is threatened to be made a party to any threatened,
pending or completed action or suit by or in the right of the corporation to procure a judgment in
its favor by reason of the fact that the person is or was a director or officer of the corporation,
against expenses (including attorneys&#146; fees) actually and reasonably incurred by the person in
connection with the defense or settlement of such action or suit if the person acted in good faith
and in a manner the person reasonably believed to be in or not opposed to the best interests of the
corporation, except that no indemnification shall be made in respect of any claim, issue or matter
as to which such person shall have been adjudged to be liable to the corporation unless and only to
the extent that the court in which such action or suit was brought shall determine upon application
that, despite the adjudication of liability but in view of all the circumstances of the case, such
person is fairly and reasonably entitled to be indemnified for such expenses which the court shall
deem proper.





<P align="center" style="font-size: 10pt">4
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Connetics has implemented such indemnification provisions in its Amended and Restated
Certificate of Incorporation and Amended and Restated Bylaws, which provide that officers and
directors shall be entitled to be indemnified by Connetics to the fullest extent permitted by law.
In addition, Connetics has entered into Indemnification Agreements with its officers and directors.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section&nbsp;145(g) of the DGCL provides, in general, that a corporation shall have the power to
purchase and maintain insurance on behalf of any person who is or was a director or officer of the
corporation against any liability asserted against the person or incurred by the person in any such
capacity, or arising out of the person&#146;s status as such, whether or not the corporation would have
the power to indemnify the person against such liability under Section&nbsp;145. Pursuant to Section
145(g) of the DGCL, Connetics maintains insurance on behalf of the directors and officers serving
at the request of Connetics.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The foregoing summaries are not intended to be complete and are necessarily subject to the
complete text of the DGCL, Connetics&#146; Amended and Restated Certificate of Incorporation and Amended
and Restated Bylaws, and the arrangements referred to above, and are qualified in their entirety by
reference thereto.

<DIV align="left">
<A name="106"></A>
</DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;7. Exemption from Registration Claimed. </B>Not applicable.


<DIV align="left">
<A name="107"></A>
</DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;8. Exhibits. </B>See Index to Exhibits <B>(page 8)</B>.


<DIV align="left">
<A name="108"></A>
</DIV>

<P align="left" style="font-size: 10pt"><B>Item&nbsp;9. Undertakings.</B>



<P align="left" style="font-size: 10pt">(a)&nbsp;The undersigned Registrant hereby undertakes:



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To file, during any period in which offers or sales are being made, a post effective
amendment to this Registration Statement to include any material information with respect to the
plan of distribution not previously disclosed in the Registration Statement or any material change
to such information in the Registration Statement.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;That, for the purpose of determining any liability under the Securities Act of 1933, each
such post-effective amendment shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;To remove from registration by means of a post-effective amendment any of the securities
being registered which remain unsold at the termination of the offering.


<P align="left" style="font-size: 10pt">(b)&nbsp;The undersigned Registrant hereby undertakes that, for purposes of determining any liability
under the Securities Act of 1933, each filing of the Registrant&#146;s annual report pursuant to Section
13(a) or Section&nbsp;15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing
of an employee benefit plan&#146;s annual report pursuant to section 15(d) of the Securities Exchange
Act of 1934) that is incorporated by reference in this Registration Statement shall be deemed to be
a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial <I>bona fide </I>offering thereof.



<P align="left" style="font-size: 10pt">(c)&nbsp;Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
permitted to directors, officers and controlling persons of the Registrant pursuant to the
foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
Commission such indemnification is against public policy as expressed in the Securities Act of 1933
and is, therefore, unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate jurisdiction the
question whether such indemnification by it is against public policy as expressed in the Securities
Act of 1933 and will be governed by the final adjudication of such issue.






<P align="center" style="font-size: 10pt">5
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left">
<A name="109"></A>
</DIV>

<P align="center" style="font-size: 10pt"><B>SIGNATURES</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Palo Alto, State of
California, on June&nbsp;20, 2005.

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="20%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="84%">&nbsp;</TD>
</TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Connetics Corporation</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">a Delaware corporation</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By: /s/ John L. Higgins</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
<TD>&nbsp;</TD><TD>&nbsp;</TD>

    <TD align="left" valign="top">John L. Higgins</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
<TD>&nbsp;</TD><TD>&nbsp;</TD>

    <TD align="left" valign="top">Executive Vice President, Finance and</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
<TD>&nbsp;</TD><TD>&nbsp;</TD>

    <TD align="left" valign="top">Corporate Development and Chief Financial
Officer</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>





<P align="center" style="font-size: 10pt">6
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">




<P align="center" style="font-size: 10pt"><B>POWER OF ATTORNEY</B>



<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and
appoints Katrina J. Church and John L. Higgins, jointly and severally, his attorneys-in-fact and
agents, each with the power of substitution and re-substitution, for him and in his name, place or
stead, in any and all capacities, to sign any and all amendments to this Registration Statement on
Form S-8 (including post-effective amendments), and to file such amendments, together with exhibits
and other documents in connection therewith, with the Securities and Exchange Commission, granting
to each attorney-in-fact and agent, full power and authority to do and perform each and every act
and thing requisite and necessary to be done in and about the premises, as fully as he or she might
or could do in person, and ratifying and confirming all that the attorney-in-facts and agents, or
his substitute or substitutes, may do or cause to be done by virtue hereof.


<P align="left" style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities and on the dates indicated:

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="20%">&nbsp;</TD>
    <TD width="10%">&nbsp;</TD>
    <TD width="40%">&nbsp;</TD>
    <TD width="10%">&nbsp;</TD>
    <TD width="20%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" ><B>Signature</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" ><B>Title</B></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" ><B>Date</B></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">

<TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">/s/
Thomas G. Wiggans
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Principal Executive Officer:</B></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="border-top: 1px solid #000000 ; margin-left:0px; text-indent:-0px">Thomas G. Wiggans
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Chief Executive Officer and Director
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top" nowrap>June 20, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Principal Financial Officer and Principal Accounting Officer:</B></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">

<TD valign="top"><DIV style="border-bottom: 1px solid #000000 ; margin-left:0px; text-indent:-0px">/s/
John L. Higgins
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Executive Vice President, Finance and Corporate</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">John L. Higgins
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Development and Chief Financial Officer
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 20, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">

<TD valign="top"><DIV style="border-bottom: 1px solid #000000 ; margin-left:0px; text-indent:-0px">/s/
G. Kirk Raab
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Chairman of the Board and Directors</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 20, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">G. Kirk Raab</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">

<TD valign="top"><DIV style="border-bottom: 1px solid #000000 ; margin-left:0px; text-indent:-0px">/s/
Eugene A. Bauer
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Director</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 20, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Eugene A. Bauer</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">

<TD valign="top"><DIV style="border-bottom: 1px solid #000000 ; margin-left:0px; text-indent:-0px">/s/
R. Andrew Eckert
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Director</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 20, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">R. Andrew Eckert</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">

<TD valign="top"><DIV style="border-bottom: 1px solid #000000 ; margin-left:0px; text-indent:-0px">/s/
Carl B. Feldbaum
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Director</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 20, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Carl B. Feldbaum</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">

<TD valign="top"><DIV style="border-bottom: 1px solid #000000 ; margin-left:0px; text-indent:-0px">/s/
Denise M. Gilbert
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Director</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 20, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Denise M. Gilbert</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">

<TD valign="top"><DIV style="border-bottom: 1px solid #000000 ; margin-left:0px; text-indent:-0px">/s/
John C. Kane
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Director</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 20, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">John C. Kane</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="border-bottom: 1px solid #000000 ; margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Director</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Thomas D. Kiley</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">

<TD valign="top"><DIV style="border-bottom: 1px solid #000000 ; margin-left:0px; text-indent:-0px">/s/
Leon E. Panetta
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top"><B>Director</B>
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">June 20, 2005</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Leon E. Panetta</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>





<P align="center" style="font-size: 10pt">7
</DIV>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#tocpage">Table of Contents</A></H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="left">
<A name="110"></A>
</DIV>

<P align="center" style="font-size: 10pt"><B>INDEX TO EXHIBITS</B>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="4%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="94%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left"><B>Exhibit</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 0px solid #000000"><B>Number</B></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">5.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Opinion of Morrison &#038; Foerster LLP</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Morrison &#038; Foerster LLP <I>(included in Exhibit&nbsp;5.1)</I></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">23.2
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Consent of Independent Registered Public Accounting Firm</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">24.1
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Power of Attorney <B><I>(see page 7)</I></B></TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<P align="center" style="font-size: 10pt">8
</DIV>

</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "f09849sv8.htm", "description": "FORM S-8", "secsgml_size_bytes": 54822}]
{"company-data": {"conformed-name": "CONNETICS CORP", "cik": "0001004960", "assigned-sic": "2834", "irs-number": "943173928", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-125983", "film-number": "05906642"}, "business-address": {"street1": "3400 W BAYSHORE RD", "city": "PALO ALTO", "state": "CA", "zip": "94303", "phone": "4158432800"}, "mail-address": {"street1": "3400 W BAYSHORE RD", "city": "PALO ALTO", "state": "CA", "zip": "94303"}, "former-company": {"former-conformed-name": "CONNECTIVE THERAPEUTICS INC", "date-changed": "19951214"}}
sv8
Table of Contents
As filed with the Securities and Exchange Commission on June 20, 2005.
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
CONNETICS CORPORATION
(Exact name of registrant as specified in its charter)
Delaware
94-3173928
(State or other jurisdiction
(I.R.S. Employer
of incorporation or organization)
Identification Number)
3160 Porter Drive
Palo Alto, California 94304
(Address of principal executive offices) (zip code)
1995 Employee Stock Purchase Plan
Stock Plan (2000)
(
Full Title of the Plans
)
Thomas G. Wiggans
Chief Executive Officer
CONNETICS CORPORATION
3160 Porter Drive
Palo Alto, California 94304
(650) 843-2800
(Name, address, and telephone number, including area code, of agent for service)
CALCULATION OF REGISTRATION FEE
Title of Securities to be
Amount to be
Proposed Maximum Offering
Proposed Maximum Aggregate
Amount of
Registered (1)
Registered (2)
Price per Share (3)
Offering Price (3)
Registration Fee
Common Stock, $0.001 par value, to be issued
under:
1995 Employee Stock Purchase Plan
179,158 shares
$
16.34
(4)
$
2,927,441.72
(4)
$
344.56
(4)
Stock Plan (2000)
Issuable Upon Exercise of Outstanding Stock Options
1,014,360 shares
$
23.88
(5)
$
24,222,916.80
(5)
$
2,851.04
(5)
Reserved for Future Grants
60,996 shares
$
16.34
(4)
$
996,674.64
(4)
$
117.31
(4)
TOTAL
1,254,514 shares
$
28,147,033.16
$
3,312.91
(1)
Each share of common stock being registered pursuant to this Registration Statement includes a
right to purchase one one-thousandth of a share of Series B Participating Preferred Stock pursuant
to an Amended and Restated Rights Agreement between the Registrant and EquiServe Trust Company,
N.A., as Rights Agent.
(2)
This Registration Statement shall also cover any additional shares of common stock which
become issuable under any of the referenced plans being registered pursuant to this Registration
Statement by reason of any stock dividend, stock split, recapitalization or any other similar
transaction effected without the Registrant's receipt of consideration, which results in an
increase in the number of the Registrant's outstanding shares of common stock.
(3)
Estimated solely for the purpose of determining the registration fee.
(4)
Computed in accordance with Rule 457(h) and Rule 457 (c) of the Securities Act of 1933, based
on the average the high and low prices of the Registrant's common stock as reported on The Nasdaq
National Market on June 15, 2005.
(5)
Computed in accordance with Rule 457(h) under the Securities Act of 1933, based on the
weighted average per share exercise price of outstanding options granted under the referenced plan.
TABLE OF CONTENTS
PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference
Item 4. Description of Securities
Item 5. Interests of Named Experts and Counsel
Item 6. Indemnification of Officers and Directors
Item 7. Exemption from Registration Claimed
Item 8. Exhibits
Item 9. Undertakings
SIGNATURES
INDEX TO EXHIBITS
EXHIBIT 5.1
EXHIBIT 23.2
Table of Contents
PART I
INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS
The documents containing the information specified in this Part I of
Form S-8
will be sent or
given to employees as specified by Rule
428(b)(1)
of the Securities and Exchange Commission (the
"SEC"). Such documents need not be filed with the SEC either as part of this Registration
Statement or as prospectuses or prospectus supplements pursuant to Rule 424. These documents and
the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Part
II of this
Form S-8
, taken together, constitute a prospectus that meets the requirements of Section
1
0(a)
of the Securities Act of 1933.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents and information filed with the Securities and Exchange Commission (the
"SEC") by Connetics Corporation (Commission File No. 0-27406) are hereby incorporated by reference
into this Registration Statement:
Connetics' Annual Report on Form 10-K for the fiscal year ended
December 31, 2004, filed on March 16, 2005 including portions of our
Proxy Statement for our 2005 Annual Meeting of Stockholders to the
extent specifically incorporated by reference therein;
Our Quarterly Report on Form 10-Q for the quarter ended March 31, 2005, filed on May 10, 2005
Connetics' Current Reports on Form 8-K, as follows:
Our Current Report on Form 8-K filed on June 13, 2005
Our Current Report on Form 8-K filed on June 9, 2005
Our Current Report on Form 8-K filed on June 6, 2005
Our Current Report on Form 8-K filed on May 19, 2005
Our Current Report on Form 8-K filed on May 18, 2005
Our Current Report on Form 8-K filed on May 12, 2005
Our Current Report on Form 8-K filed on May 10, 2005
Our Current Report on Form 8-K filed on April 26, 2005
Our Current Report on Form 8-K filed on April 18, 2005
Our Current Report on Form 8-K filed on April 7, 2005
Our Current Report on Form 8-K filed on April 1, 2005
Our Current Report on Form 8-K filed on March 25, 2005
Our Current Report on Form 8-K filed on March 22, 2005
Our Current Report on Form 8-K filed on March 18, 2005
Our Current Report on Form 8-K filed on March 17, 2005
Our Current Report on Form 8-K filed on March 14, 2005
Table of Contents
Our Current Report on Form 8-K filed on February 18, 2005
Our Current Report on Form 8-K filed on February 1, 2005
Our Current Report on Form 8-K filed on January 28, 2005
The description of Connetics' common stock contained in our
Registration Statement on Form 8-A dated December 8, 1995, and filed
with the SEC on December 11, 1995, including any amendments or reports
filed with the SEC for the purpose of updating such description; and
The description of Connetics' Preferred Share Purchase Rights
contained in our Registration Statement on Form 8-A, dated May 20,
1997 and filed with the SEC on May 23, 1997, as amended by Amendment
No. 1 thereto on Form 8-A/A, dated November 27, 2001 and filed with
the SEC on November 28, 2001, including any amendments or reports
filed with the SEC for the purpose of updating such description.
3
Table of Contents
All reports and other documents filed by Connetics pursuant to Section 13(a), 13(c), 14 and
15(d) of the Exchange Act, after the date of this Registration Statement and prior to the filing of
a post-effective amendment which indicates that all securities offered hereby have been sold or
which deregisters all securities then remaining unsold, shall be deemed to be incorporated by
reference into this Registration Statement and to be part of this Registration Statement from the
date such documents are filed. In no event, however, will any of the information that we disclose
under Item 2.02 or Item 7.01 of any Current Report on Form 8-K that we furnish with the SEC be
incorporated by reference into, or otherwise included in, this Registration Statement.
Any statement contained in a document incorporated or deemed to be incorporated by reference
in this Registration Statement shall be deemed to be modified or superseded for purposes of this
Registration Statement to the extent that a statement contained in this Registration Statement (or
in any other subsequently filed document which also is or is deemed to be incorporated by reference
herein) modifies or supersedes such statement. Any such statement so modified or superseded shall
not be deemed to constitute a part of this Registration Statement, except as so modified or
superseded.
Item 4. Description of Securities.
Not applicable.
Item 5. Interests of Named Experts and Counsel.
Not applicable.
Item 6. Indemnification of Directors and Officers.
Section 145(a) of the Delaware General Corporation Law, or DGCL, provides, in general, that a
corporation shall have the power to indemnify any person who was or is a party or is threatened to
be made a party to any threatened, pending or completed action, suit or proceeding, other than an
action by or in the right of the corporation, by reason of the fact that the person is or was a
director or officer of the corporation, against expenses (including attorneys' fees), judgments,
fines and amounts paid in settlement actually and reasonably incurred by the person in connection
with such action, suit or proceeding, if the person acted in good faith and in a manner the person
reasonably believed to be in or not opposed to the best interests of the corporation and if, with
respect to any criminal action or proceeding, the person had no reasonable cause to believe the
person's conduct was unlawful.
Section 145(b) of the DGCL provides, in general, that a corporation shall have the power to
indemnify any person who was or is a party or is threatened to be made a party to any threatened,
pending or completed action or suit by or in the right of the corporation to procure a judgment in
its favor by reason of the fact that the person is or was a director or officer of the corporation,
against expenses (including attorneys' fees) actually and reasonably incurred by the person in
connection with the defense or settlement of such action or suit if the person acted in good faith
and in a manner the person reasonably believed to be in or not opposed to the best interests of the
corporation, except that no indemnification shall be made in respect of any claim, issue or matter
as to which such person shall have been adjudged to be liable to the corporation unless and only to
the extent that the court in which such action or suit was brought shall determine upon application
that, despite the adjudication of liability but in view of all the circumstances of the case, such
person is fairly and reasonably entitled to be indemnified for such expenses which the court shall
deem proper.
4
Table of Contents
Connetics has implemented such indemnification provisions in its Amended and Restated
Certificate of Incorporation and Amended and Restated Bylaws, which provide that officers and
directors shall be entitled to be indemnified by Connetics to the fullest extent permitted by law.
In addition, Connetics has entered into Indemnification Agreements with its officers and directors.
Section 145(g) of the DGCL provides, in general, that a corporation shall have the power to
purchase and maintain insurance on behalf of any person who is or was a director or officer of the
corporation against any liability asserted against the person or incurred by the person in any such
capacity, or arising out of the person's status as such, whether or not the corporation would have
the power to indemnify the person against such liability under Section 145. Pursuant to Section
145(g) of the DGCL, Connetics maintains insurance on behalf of the directors and officers serving
at the request of Connetics.
The foregoing summaries are not intended to be complete and are necessarily subject to the
complete text of the DGCL, Connetics' Amended and Restated Certificate of Incorporation and Amended
and Restated Bylaws, and the arrangements referred to above, and are qualified in their entirety by
reference thereto.
Item 7. Exemption from Registration Claimed.
Not applicable.
Item 8. Exhibits.
See Index to Exhibits
(page 8)
.
Item 9. Undertakings.
(a) The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a post effective
amendment to this Registration Statement to include any material information with respect to the
plan of distribution not previously disclosed in the Registration Statement or any material change
to such information in the Registration Statement.
(2) That, for the purpose of determining any liability under the Securities Act of 1933, each
such post-effective amendment shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.
(3) To remove from registration by means of a post-effective amendment any of the securities
being registered which remain unsold at the termination of the offering.
(b) The undersigned Registrant hereby undertakes that, for purposes of determining any liability
under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to Section
13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing
of an employee benefit plan's annual report pursuant to section 15(d) of the Securities Exchange
Act of 1934) that is incorporated by reference in this Registration Statement shall be deemed to be
a new registration statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(c) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be
permitted to directors, officers and controlling persons of the Registrant pursuant to the
foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the
Commission such indemnification is against public policy as expressed in the Securities Act of 1933
and is, therefore, unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in connection with the
securities being registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate jurisdiction the
question whether such indemnification by it is against public policy as expressed in the Securities
Act of 1933 and will be governed by the final adjudication of such issue.
5
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it
has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and
has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Palo Alto, State of
California, on June 20, 2005.
Connetics Corporation
a Delaware corporation
By: /s/ John L. Higgins
John L. Higgins
Executive Vice President, Finance and
Corporate Development and Chief Financial
Officer
6
Table of Contents
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and
appoints Katrina J. Church and John L. Higgins, jointly and severally, his attorneys-in-fact and
agents, each with the power of substitution and re-substitution, for him and in his name, place or
stead, in any and all capacities, to sign any and all amendments to this Registration Statement on
Form S-8 (including post-effective amendments), and to file such amendments, together with exhibits
and other documents in connection therewith, with the Securities and Exchange Commission, granting
to each attorney-in-fact and agent, full power and authority to do and perform each and every act
and thing requisite and necessary to be done in and about the premises, as fully as he or she might
or could do in person, and ratifying and confirming all that the attorney-in-facts and agents, or
his substitute or substitutes, may do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has
been signed by the following persons in the capacities and on the dates indicated:
Signature
Title
Date
/s/
Thomas G. Wiggans
Principal Executive Officer:
Thomas G. Wiggans
Chief Executive Officer and Director
June 20, 2005
Principal Financial Officer and Principal Accounting Officer:
/s/
John L. Higgins
Executive Vice President, Finance and Corporate
John L. Higgins
Development and Chief Financial Officer
June 20, 2005
/s/
G. Kirk Raab
Chairman of the Board and Directors
June 20, 2005
G. Kirk Raab
/s/
Eugene A. Bauer
Director
June 20, 2005
Eugene A. Bauer
/s/
R. Andrew Eckert
Director
June 20, 2005
R. Andrew Eckert
/s/
Carl B. Feldbaum
Director
June 20, 2005
Carl B. Feldbaum
/s/
Denise M. Gilbert
Director
June 20, 2005
Denise M. Gilbert
/s/
John C. Kane
Director
June 20, 2005
John C. Kane
Director
Thomas D. Kiley
/s/
Leon E. Panetta
Director
June 20, 2005
Leon E. Panetta
7
Table of Contents
INDEX TO EXHIBITS
Exhibit
Number
5.1
Opinion of Morrison & Foerster LLP
23.1
Consent of Morrison & Foerster LLP
(included in Exhibit 5.1)
23.2
Consent of Independent Registered Public Accounting Firm
24.1
Power of Attorney
(see page 7)
8