REGISTRATION NO. 333-
================================================================================


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     ------

                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                                     ------

                           ORASURE TECHNOLOGIES, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

          Delaware                                     36-4370966
    (STATE OF INCORPORATION)                  (IRS EMPLOYER IDENTIFICATION NO.)

    8505 S.W. Creekside Place
    Beaverton, Oregon                                     97008
(ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)               (ZIP CODE)


                 ORASURE TECHNOLOGIES, INC. STOCK PURCHASE PLAN
                            (FULL TITLE OF THE PLAN)


                               Robert D. Thompson
                             Chief Executive Officer
                           OraSure Technologies, Inc.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008
                            Telephone (503) 641-6115
           (NAME, ADDRESS, AND TELEPHONE NUMBER OF AGENT FOR SERVICE)



                         CALCULATION OF REGISTRATION FEE
<TABLE>
 ===========================================================================================
                                        PROPOSED MAXIMUM
        TITLE OF          AMOUNT TO BE   OFFERING PRICE  PROPOSED MAXIMUM     AMOUNT OF
    SECURITIES TO BE       REGISTERED      PER SHARE         AGGREGATE     REGISTRATION FEE
       REGISTERED                                         OFFERING PRICE
 -------------------------------------------------------------------------------------------
<S>                      <C>                  <C>          <C>                <C>
 Common Stock, par       440,997 shares       (1)          $4,237,755(1)      $1,119.00
 value $.000001 (1)
 ===========================================================================================
</TABLE>

(1) Includes  rights under the OraSure  Technologies,  Inc. Stock Purchase Plan.
    Pursuant to Rule 457(h),  the proposed maximum aggregate  offering price and
    the  registration  fee have  been  computed  for 6,249  shares  based on the
    exercise  price of $3.96 per share,  for 50,162 shares based on the exercise
    price of $2.736 per share, and for the remaining 384,586 shares based on the
    average of the high and low sales  prices,  $10.59,  reported  for shares of
    OraSure  Technologies,  Inc.  Common Stock,  $.000001 par value (the "Common
    Stock"), on the Nasdaq National Market on October 20, 2000.

================================================================================

<PAGE>

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.
         ---------------------------------------

      Amendment No. 5 to the  Registration  Statement on Form S-4  (Registration
No.  333-39210) (the "Form S-4"),  including the description of the registrant's
capital  stock  contained  in the  prospectus  included in the Form S-4, and the
Current Report on Form 8-K dated  September 29, 2000, as filed by the registrant
with the Securities and Exchange  Commission,  are  incorporated by reference in
this registration statement.

      The registrant is the successor to Epitope,  Inc.,  under Rule 12g-3(a) of
the Securities  Exchange Act of 1934, as amended (the "Exchange  Act").  Epitope
was previously  subject to the reporting  requirements  of the Exchange Act. The
following documents as filed by Epitope are also incorporated by reference:

      (a)  Epitope's  Annual  Report  on Form  10-K for the  fiscal  year  ended
September 30, 1999;

      (b) Epitope's Quarterly Reports on Form 10-Q for the fiscal quarters ended
December 31, 1999, March 31, 2000, and June 30, 2000; and

      (c) Epitope's  Current  Reports on Form 8-K dated October 1, 1999,  May 6,
2000, and September 29, 2000.

      In addition,  all documents filed by the registrant subsequent to the date
of filing of this Registration  Statement pursuant to Sections 13(a),  13(c), 14
or 15(d) of the Exchange Act prior to the filing of a  post-effective  amendment
which indicates that all securities  offered have been sold or which deregisters
all securities  then remaining  unsold,  shall be deemed to be  incorporated  by
reference into this registration statement and to be a part hereof from the date
of filing of such documents.

Item 4.  Description of Securities.
         -------------------------

            Not applicable.

Item 5.  Interests of Named Experts and Counsel.
         --------------------------------------

            None.

Item 6.  Indemnification of Directors and Officers.
         -----------------------------------------

      Delaware law  authorizes a corporation  to limit or eliminate the personal
liability  of its  directors  for  monetary  damages for breach of a  director's
fiduciary  duty of care.  Delaware  law further  enables  corporations  to limit
available relief to equitable remedies such as injunction or rescission.  Absent
the  limitations  authorized by Delaware  law,  directors  are  accountable  for
monetary  damages for conduct  constituting  gross negligence in the exercise of
their duty of care. The  registrant's  Certificate of  Incorporation  limits the
liability of its  directors  to the fullest  extent  permitted by Delaware  law.
Accordingly,  the  registrant's  directors will not be personally  liable to the
registrant or its  stockholders  for monetary  damages for breach of a fiduciary
duty as a director,  except for liability for breach of the duty of loyalty, for
acts or omissions not in good faith or that involve intentional  misconduct or a
knowing  violation of law, for unlawful  payments of dividends or unlawful stock
repurchases or redemptions as provided in Section 174 of the General Corporation
Law of the State of  Delaware  or for any  transaction  in which a director  has
derived an improper personal benefit.

                                       2
<PAGE>

      The  registrant's  bylaws  require it to indemnify  to the fullest  extent
permitted by Delaware law any person who is a party or is  threatened to be made
a party to any action, suit or proceeding by reason of the fact that such person
is or was a  director,  officer,  employee  or  agent of the  registrant,  or is
serving as a director,  officer,  employee or agent of another enterprise at the
registrant's  request.  Indemnification  is not,  however,  permitted  under the
bylaws  unless  the  person  acted in good  faith  and in a manner  such  person
reasonably  believed to be in or not opposed to the registrant's  best interests
and, with respect to any criminal action or proceeding,  that such person had no
reasonable  cause to believe  such  person's  conduct was  unlawful.  The bylaws
further  provide  that the  registrant  shall not  indemnify  any person for any
liabilities  or expenses  incurred by such person in connection  with an action,
suit or proceeding by or in the right of the registrant in respect of any claim,
issue or matter as to which such person shall have been adjudged to be liable to
the  registrant,  unless  and only to the  extent  that the  court in which  the
action,  suit or proceeding is brought determines that the person is entitled to
indemnity for such expenses.  The indemnification  provided by the bylaws is not
exclusive  of any other  rights to which those  seeking  indemnification  may be
otherwise entitled.

      The registrant has entered into  indemnification  agreements  with each of
its directors  and officers.  The  indemnification  agreements  provide that the
registrant will indemnify the directors and officers against all liabilities and
expenses actually and reasonably incurred in connection with any action, suit or
proceeding  (including an action by or in the right of the  registrant) to which
any of them is, was or at any time becomes a party,  or is threatened to be made
a party,  by reason of their status as a director or officer of the  registrant,
or by reason of their  serving or having  served at the  request or on behalf of
the  registrant  as a  director,  officer,  trustee  or in any other  comparable
position  of any other  enterprise  to the  fullest  extent  allowed by law.  No
indemnity will be provided under the indemnification  agreements for any amounts
for which  indemnity  is provided  by any other  indemnification  obligation  or
insurance  maintained  by the  registrant or  otherwise.  Indemnity  will not be
available  to any  director  or officer  on account of conduct  which is finally
adjudged by a court to have been knowingly fraudulent, deliberately dishonest or
willful  misconduct,   if  a  final  court  adjudication  determines  that  such
indemnification  is not lawful,  or in respect of any suit in which  judgment is
rendered  against any director or officer for an accounting of profits made from
a purchase or sale of securities of the registrant in violation of Section 16(b)
of the  Exchange  Act or of any similar  law, or on account of any  remuneration
paid to any  director  or  officer  which is  adjudicated  to have  been paid in
violation of law.

      The  registrant  has also  obtained  director's  and  officer's  liability
insurance.

Item 7.  Exemption from Registration Claimed.
         -----------------------------------

      Not applicable.

Item 8.  Exhibits.
         --------

      The  Index  to  Exhibits  listing  the  exhibits  required  by Item 601 of
Regulation  S-K  immediately  follows the  signature  page of this  Registration
Statement.

Item 9.  Undertakings.
         ------------

      (a)  The registrant hereby undertakes:

            (1) To file,  during any  period in which  offers or sales are being
         made, a post-effective amendment to this registration statement:

                  (i) To include any prospectus  required by Section 10(a)(3) of
         the Securities Act of 1933 ("Securities Act");

                                       3
<PAGE>

                  (ii) To reflect in the  prospectus any facts or events arising
         after the  effective  date of the  registration  statement (or the most
         recent post-effective amendment thereof) which,  individually or in the
         aggregate,  represent a fundamental change in the information set forth
         in the registration statement;

                  (iii) To include any material  information with respect to the
         plan of  distribution  not  previously  disclosed  in the  registration
         statement  or  any  material   change  to  such   information   in  the
         registration statement;

provided,  however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
information  required  to be  included in a  post-effective  amendment  by those
paragraphs is contained in periodic reports filed by the registrant  pursuant to
Section 13 or 15(d) of the  Exchange Act that are  incorporated  by reference in
the registration statement.

            (2) That,  for the purpose of  determining  any liability  under the
Securities Act, each such  post-effective  amendment shall be deemed to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

            (3)  To  remove  from  registration  by  means  of a  post-effective
amendment  any of the  securities  being  registered  that remain  unsold at the
termination of the offering.

      (b) The undersigned  registrant  hereby  undertakes  that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  annual  report  pursuant to Section 13(a) or 15(d) of the Exchange
Act (and,  where  applicable,  each filing of an employee  benefit plan's annual
report  pursuant to Section 15(d) of the Exchange Act) that is  incorporated  by
reference in the registration statement shall be deemed to be a new registration
statement relating to the securities  offered therein,  and the offering of such
securities  at that time shall be deemed to be the  initial  bona fide  offering
thereof.

      (h)  Insofar  as  indemnification   for  liabilities   arising  under  the
Securities Act may be permitted to directors,  officers and controlling  persons
of the  registrant  pursuant to the  provisions  described  in Item 6 above,  or
otherwise, the registrant has been advised that in the opinion of the Securities
and  Exchange  Commission  such  indemnification  is  against  public  policy as
expressed in the Securities Act and is, therefore,  unenforceable.  In the event
that a claim  for  indemnification  against  such  liabilities  (other  than the
payment by the registrant of expenses incurred or paid by a director, officer or
controlling  person of the registrant in the  successful  defense of any action,
suit or proceeding) is asserted by such director,  officer or controlling person
in connection with the securities being registered,  the registrant will, unless
in the  opinion  of its  counsel  the matter  has been  settled  by  controlling
precedent,  submit to a court of appropriate  jurisdiction  the question whether
such  indemnification  by it is  against  public  policy  as  expressed  in  the
Securities Act and will be governed by the final adjudication of such issue. The
undertaking  of the  registrant  in the  preceding  sentence  does not  apply to
insurance against liability arising under the Securities Act.

                                       4
<PAGE>

                                   SIGNATURES

The Registrant.
--------------

      Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the  city of  Beaverton,  state  of  Oregon,  on the 25th day of
October, 2000.

                                    OraSure Technologies, Inc.
                                    (Registrant)


                                    By   /s/ Charles E. Bergeron
                                         Charles E. Bergeron
                                         Chief Financial Officer


      Pursuant  to  the  requirements  of  the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities indicated as of the 25th day of October, 2000.

                  Signature                           Title
                  ---------                           -----

      (1)  Principal Executive Officer

      * Robert D. Thompson                Chief Executive Officer and Director

      (2)  Principal Financial Officer

      /s/ Charles E. Bergeron
      Charles E. Bergeron                 Vice  President  and  Chief  Financial
                                          Officer

      (3)  Principal Accounting Officer

      /s/ Theodore R. Gwin
      Theodore R. Gwin                    Controller

      (4)  A majority of the Board of Directors

      * ROGER L. PRINGLE                  Director
      * FRANK G. HAUSMANN, JR.            Director
      * MICHAEL G. BOLTON                 Director
      * WILLIAM W. CROUSE                 Director
      * MICHAEL J. GAUSLING               Director

* By /s/ Charles E. Bergeron
     Charles E. Bergeron
     Attorney-in-fact

                                       5
<PAGE>


                                INDEX TO EXHIBITS


4.1   Certificate of Incorporation of the registrant.  Incorporated by reference
      to Exhibit  3.1 to the  registrant's  Registration  Statement  on Form S-4
      (File No. 333-39210) ("Form S-4").

4.1.1 Certificate  of Amendment to Certificate  of  Incorporation  dated May 23,
      2000. Incorporated by reference to Exhibit 3.1.1 to Form S-4.

4.2   Bylaws of the  registrant.  Incorporated  by reference to Exhibit 3.2 to
      Form S-4.

4.3   Rights  Agreement  dated as of May 6, 2000,  between  the  registrant  and
      ChaseMellon Shareholder Services, L.L.C., as Rights Agent. Incorporated by
      reference to Exhibit 4.2 to Form S-4.

5     Opinion of Miller Nash LLP.

23.1  Consent of PricewaterhouseCoopers LLP.

23.2  Consent of Miller Nash LLP.  Included in Exhibit 5.

24    Power of attorney of certain officers and directors.

--------------------

      Other exhibits listed in Item 601 to Regulation S-K are not applicable.


                                       6
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REGISTRATION NO. 333-
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     ------

                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                                     ------

                           ORASURE TECHNOLOGIES, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

          Delaware                                     36-4370966
    (STATE OF INCORPORATION)                  (IRS EMPLOYER IDENTIFICATION NO.)

    8505 S.W. Creekside Place
    Beaverton, Oregon                                     97008
(ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)               (ZIP CODE)

                 ORASURE TECHNOLOGIES, INC. STOCK PURCHASE PLAN
                            (FULL TITLE OF THE PLAN)

                               Robert D. Thompson
                             Chief Executive Officer
                           OraSure Technologies, Inc.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008
                            Telephone (503) 641-6115
           (NAME, ADDRESS, AND TELEPHONE NUMBER OF AGENT FOR SERVICE)

                         CALCULATION OF REGISTRATION FEE

 ===========================================================================================
                                        PROPOSED MAXIMUM
        TITLE OF          AMOUNT TO BE   OFFERING PRICE  PROPOSED MAXIMUM     AMOUNT OF
    SECURITIES TO BE       REGISTERED      PER SHARE         AGGREGATE     REGISTRATION FEE
       REGISTERED                                         OFFERING PRICE
 -------------------------------------------------------------------------------------------
Common Stock, par       440,997 shares       (1)          $4,237,755(1)      $1,119.00
 value $.000001 (1)
 ===========================================================================================
(1) Includes  rights under the OraSure  Technologies,  Inc. Stock Purchase Plan.
    Pursuant to Rule 457(h),  the proposed maximum aggregate  offering price and
    the  registration  fee have  been  computed  for 6,249  shares  based on the
    exercise  price of $3.96 per share,  for 50,162 shares based on the exercise
    price of $2.736 per share, and for the remaining 384,586 shares based on the
    average of the high and low sales  prices,  $10.59,  reported  for shares of
    OraSure  Technologies,  Inc.  Common Stock,  $.000001 par value (the "Common
    Stock"), on the Nasdaq National Market on October 20, 2000.

================================================================================
PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.
         ---------------------------------------

      Amendment No. 5 to the  Registration  Statement on Form S-4  (Registration
No.  333-39210) (the "Form S-4"),  including the description of the registrant's
capital  stock  contained  in the  prospectus  included in the Form S-4, and the
Current Report on Form 8-K dated  September 29, 2000, as filed by the registrant
with the Securities and Exchange  Commission,  are  incorporated by reference in
this registration statement.

      The registrant is the successor to Epitope,  Inc.,  under Rule 12g-3(a) of
the Securities  Exchange Act of 1934, as amended (the "Exchange  Act").  Epitope
was previously  subject to the reporting  requirements  of the Exchange Act. The
following documents as filed by Epitope are also incorporated by reference:

      (a)  Epitope's  Annual  Report  on Form  10-K for the  fiscal  year  ended
September 30, 1999;

      (b) Epitope's Quarterly Reports on Form 10-Q for the fiscal quarters ended
December 31, 1999, March 31, 2000, and June 30, 2000; and

      (c) Epitope's  Current  Reports on Form 8-K dated October 1, 1999,  May 6,
2000, and September 29, 2000.

      In addition,  all documents filed by the registrant subsequent to the date
of filing of this Registration  Statement pursuant to Sections 13(a),  13(c), 14
or 15(d) of the Exchange Act prior to the filing of a  post-effective  amendment
which indicates that all securities  offered have been sold or which deregisters
all securities  then remaining  unsold,  shall be deemed to be  incorporated  by
reference into this registration statement and to be a part hereof from the date
of filing of such documents.

Item 4.  Description of Securities.
         -------------------------

            Not applicable.

Item 5.  Interests of Named Experts and Counsel.
         --------------------------------------

            None.

Item 6.  Indemnification of Directors and Officers.
         -----------------------------------------

      Delaware law  authorizes a corporation  to limit or eliminate the personal
liability  of its  directors  for  monetary  damages for breach of a  director's
fiduciary  duty of care.  Delaware  law further  enables  corporations  to limit
available relief to equitable remedies such as injunction or rescission.  Absent
the  limitations  authorized by Delaware  law,  directors  are  accountable  for
monetary  damages for conduct  constituting  gross negligence in the exercise of
their duty of care. The  registrant's  Certificate of  Incorporation  limits the
liability of its  directors  to the fullest  extent  permitted by Delaware  law.
Accordingly,  the  registrant's  directors will not be personally  liable to the
registrant or its  stockholders  for monetary  damages for breach of a fiduciary
duty as a director,  except for liability for breach of the duty of loyalty, for
acts or omissions not in good faith or that involve intentional  misconduct or a
knowing  violation of law, for unlawful  payments of dividends or unlawful stock
repurchases or redemptions as provided in Section 174 of the General Corporation
Law of the State of  Delaware  or for any  transaction  in which a director  has
derived an improper personal benefit.

                                       2
The  registrant's  bylaws  require it to indemnify  to the fullest  extent
permitted by Delaware law any person who is a party or is  threatened to be made
a party to any action, suit or proceeding by reason of the fact that such person
is or was a  director,  officer,  employee  or  agent of the  registrant,  or is
serving as a director,  officer,  employee or agent of another enterprise at the
registrant's  request.  Indemnification  is not,  however,  permitted  under the
bylaws  unless  the  person  acted in good  faith  and in a manner  such  person
reasonably  believed to be in or not opposed to the registrant's  best interests
and, with respect to any criminal action or proceeding,  that such person had no
reasonable  cause to believe  such  person's  conduct was  unlawful.  The bylaws
further  provide  that the  registrant  shall not  indemnify  any person for any
liabilities  or expenses  incurred by such person in connection  with an action,
suit or proceeding by or in the right of the registrant in respect of any claim,
issue or matter as to which such person shall have been adjudged to be liable to
the  registrant,  unless  and only to the  extent  that the  court in which  the
action,  suit or proceeding is brought determines that the person is entitled to
indemnity for such expenses.  The indemnification  provided by the bylaws is not
exclusive  of any other  rights to which those  seeking  indemnification  may be
otherwise entitled.

      The registrant has entered into  indemnification  agreements  with each of
its directors  and officers.  The  indemnification  agreements  provide that the
registrant will indemnify the directors and officers against all liabilities and
expenses actually and reasonably incurred in connection with any action, suit or
proceeding  (including an action by or in the right of the  registrant) to which
any of them is, was or at any time becomes a party,  or is threatened to be made
a party,  by reason of their status as a director or officer of the  registrant,
or by reason of their  serving or having  served at the  request or on behalf of
the  registrant  as a  director,  officer,  trustee  or in any other  comparable
position  of any other  enterprise  to the  fullest  extent  allowed by law.  No
indemnity will be provided under the indemnification  agreements for any amounts
for which  indemnity  is provided  by any other  indemnification  obligation  or
insurance  maintained  by the  registrant or  otherwise.  Indemnity  will not be
available  to any  director  or officer  on account of conduct  which is finally
adjudged by a court to have been knowingly fraudulent, deliberately dishonest or
willful  misconduct,   if  a  final  court  adjudication  determines  that  such
indemnification  is not lawful,  or in respect of any suit in which  judgment is
rendered  against any director or officer for an accounting of profits made from
a purchase or sale of securities of the registrant in violation of Section 16(b)
of the  Exchange  Act or of any similar  law, or on account of any  remuneration
paid to any  director  or  officer  which is  adjudicated  to have  been paid in
violation of law.

      The  registrant  has also  obtained  director's  and  officer's  liability
insurance.

Item 7.  Exemption from Registration Claimed.
         -----------------------------------

      Not applicable.

Item 8.  Exhibits.
         --------

      The  Index  to  Exhibits  listing  the  exhibits  required  by Item 601 of
Regulation  S-K  immediately  follows the  signature  page of this  Registration
Statement.

Item 9.  Undertakings.
         ------------

      (a)  The registrant hereby undertakes:

            (1) To file,  during any  period in which  offers or sales are being
         made, a post-effective amendment to this registration statement:

                  (i) To include any prospectus  required by Section 10(a)(3) of
         the Securities Act of 1933 ("Securities Act");

                                       3
(ii) To reflect in the  prospectus any facts or events arising
         after the  effective  date of the  registration  statement (or the most
         recent post-effective amendment thereof) which,  individually or in the
         aggregate,  represent a fundamental change in the information set forth
         in the registration statement;

                  (iii) To include any material  information with respect to the
         plan of  distribution  not  previously  disclosed  in the  registration
         statement  or  any  material   change  to  such   information   in  the
         registration statement;

provided,  however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
information  required  to be  included in a  post-effective  amendment  by those
paragraphs is contained in periodic reports filed by the registrant  pursuant to
Section 13 or 15(d) of the  Exchange Act that are  incorporated  by reference in
the registration statement.

            (2) That,  for the purpose of  determining  any liability  under the
Securities Act, each such  post-effective  amendment shall be deemed to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

            (3)  To  remove  from  registration  by  means  of a  post-effective
amendment  any of the  securities  being  registered  that remain  unsold at the
termination of the offering.

      (b) The undersigned  registrant  hereby  undertakes  that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  annual  report  pursuant to Section 13(a) or 15(d) of the Exchange
Act (and,  where  applicable,  each filing of an employee  benefit plan's annual
report  pursuant to Section 15(d) of the Exchange Act) that is  incorporated  by
reference in the registration statement shall be deemed to be a new registration
statement relating to the securities  offered therein,  and the offering of such
securities  at that time shall be deemed to be the  initial  bona fide  offering
thereof.

      (h)  Insofar  as  indemnification   for  liabilities   arising  under  the
Securities Act may be permitted to directors,  officers and controlling  persons
of the  registrant  pursuant to the  provisions  described  in Item 6 above,  or
otherwise, the registrant has been advised that in the opinion of the Securities
and  Exchange  Commission  such  indemnification  is  against  public  policy as
expressed in the Securities Act and is, therefore,  unenforceable.  In the event
that a claim  for  indemnification  against  such  liabilities  (other  than the
payment by the registrant of expenses incurred or paid by a director, officer or
controlling  person of the registrant in the  successful  defense of any action,
suit or proceeding) is asserted by such director,  officer or controlling person
in connection with the securities being registered,  the registrant will, unless
in the  opinion  of its  counsel  the matter  has been  settled  by  controlling
precedent,  submit to a court of appropriate  jurisdiction  the question whether
such  indemnification  by it is  against  public  policy  as  expressed  in  the
Securities Act and will be governed by the final adjudication of such issue. The
undertaking  of the  registrant  in the  preceding  sentence  does not  apply to
insurance against liability arising under the Securities Act.

                                       4
SIGNATURES

The Registrant.
--------------

      Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the  city of  Beaverton,  state  of  Oregon,  on the 25th day of
October, 2000.

                                    OraSure Technologies, Inc.
                                    (Registrant)

                                    By   /s/ Charles E. Bergeron
                                         Charles E. Bergeron
                                         Chief Financial Officer

      Pursuant  to  the  requirements  of  the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities indicated as of the 25th day of October, 2000.

                  Signature                           Title
                  ---------                           -----

      (1)  Principal Executive Officer

      * Robert D. Thompson                Chief Executive Officer and Director

      (2)  Principal Financial Officer

      /s/ Charles E. Bergeron
      Charles E. Bergeron                 Vice  President  and  Chief  Financial
                                          Officer

      (3)  Principal Accounting Officer

      /s/ Theodore R. Gwin
      Theodore R. Gwin                    Controller

      (4)  A majority of the Board of Directors

      * ROGER L. PRINGLE                  Director
      * FRANK G. HAUSMANN, JR.            Director
      * MICHAEL G. BOLTON                 Director
      * WILLIAM W. CROUSE                 Director
      * MICHAEL J. GAUSLING               Director

* By /s/ Charles E. Bergeron
     Charles E. Bergeron
     Attorney-in-fact

                                       5
INDEX TO EXHIBITS

4.1   Certificate of Incorporation of the registrant.  Incorporated by reference
      to Exhibit  3.1 to the  registrant's  Registration  Statement  on Form S-4
      (File No. 333-39210) ("Form S-4").

4.1.1 Certificate  of Amendment to Certificate  of  Incorporation  dated May 23,
      2000. Incorporated by reference to Exhibit 3.1.1 to Form S-4.

4.2   Bylaws of the  registrant.  Incorporated  by reference to Exhibit 3.2 to
      Form S-4.

4.3   Rights  Agreement  dated as of May 6, 2000,  between  the  registrant  and
      ChaseMellon Shareholder Services, L.L.C., as Rights Agent. Incorporated by
      reference to Exhibit 4.2 to Form S-4.

5     Opinion of Miller Nash LLP.

23.1  Consent of PricewaterhouseCoopers LLP.

23.2  Consent of Miller Nash LLP.  Included in Exhibit 5.

24    Power of attorney of certain officers and directors.

--------------------

      Other exhibits listed in Item 601 to Regulation S-K are not applicable.

                                       6