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<P ALIGN=CENTER><FONT SIZE="2"><B>As filed with the Securities and Exchange
Commission on June 16, 2000</B></FONT> </P>

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<P ALIGN=RIGHT><FONT SIZE=2>Registration No. 333-____________ </FONT> </P>

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<H1 ALIGN=CENTER><FONT SIZE="2"><B>SECURITIES AND EXCHANGE COMMISSION</B><BR>
Washington, D.C. 20549</FONT></H1>

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<P ALIGN=CENTER><FONT SIZE=2><B>FORM S-8</B><BR>
<B>REGISTRATION STATEMENT</B><BR>
<I>Under</I><BR>
<I>The Securities Act of 1933</I></FONT> </P>

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<P ALIGN=CENTER><FONT SIZE="3"><B>BIOCRYST PHARMACEUTICALS, INC.</B></FONT><BR>
<FONT SIZE="2">(Exact name of registrant as specified in its charter)</FONT> </P>
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<TD ALIGN=CENTER WIDTH=50%><FONT SIZE="2"><B>Delaware</B><BR>(State or other jurisdiction <BR>of incorporation or organization)</FONT> </TD>
<TD ALIGN=CENTER WIDTH=50%><FONT SIZE="2"><B>62-1413174</B><BR>
(IRS Employer Identification No.) </FONT> </TD>
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<p ALIGN=CENTER><FONT SIZE="2"><B>2190 Parkway Lake Drive<BR>Birmingham, Alabama 35244</B><BR>(Address of principal executive offices) (Zip Code)</FONT> </P>



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<P ALIGN=CENTER><FONT SIZE="2"><B>1991 STOCK OPTION PLAN</B> <BR>
<B>(Amended and Restated as of March 6, 2000)</B> <BR>(Full title of the Plan)</FONT> </P>


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<P ALIGN=CENTER><FONT SIZE="2"><B>Charles E. Bugg, Ph.D.</B><BR>
<B>Chairman and Chief Executive Officer</B><BR>
<B>BioCryst Pharmaceuticals</B><BR>
<B>2190 Parkway Lake Drive</B><BR>
<B>Birmingham, Alabama 35244</B><BR>
(Name and address of agent for service)<BR>
<B>(205) 444-4600</B><BR>
(Telephone number, including area code, of agent for service)</font></p>

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<H1 ALIGN=CENTER><FONT SIZE=2>CALCULATION OF REGISTRATION FEE</FONT></H1>

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     <TH COLSPAN="2"><FONT SIZE=1>Title of Securities to be<BR>Registered </FONT><HR WIDTH=70% SIZE=1 NOSHADE> </TH>
     <TH COLSPAN="2"><FONT SIZE=1>Amount to be<BR>Registered(1) </FONT><HR WIDTH=70% SIZE=1 NOSHADE> </TH>
     <TH COLSPAN="2"><FONT SIZE=1>Proposed<BR>Maximum Offering<BR>Price per Share(2) </FONT><HR WIDTH=70% SIZE=1 NOSHADE> </TH>
     <TH COLSPAN="2"><FONT SIZE=1>Proposed<BR>Maximum Aggregate<BR>Offering Price(2) </FONT><HR WIDTH=90% SIZE=1 NOSHADE> </TH>
     <TH COLSPAN="2"><FONT SIZE=1>Amount of<BR>Registration Fee </FONT><HR WIDTH=70% SIZE=1 NOSHADE></TH></TR>
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     <TD WIDTH="29%" ALIGN="LEFT"><FONT SIZE="2"><U>1991 Stock Option Plan</U></FONT> </TD>
     <TD WIDTH="1%" ALIGN="LEFT">&nbsp;</TD>
     <TD WIDTH="16%" ALIGN="RIGHT"></TD>
        <TD WIDTH="3%" ALIGN="LEFT">&nbsp;</TD>
     <TD WIDTH="12%" ALIGN="RIGHT"></TD>
        <TD WIDTH="7%" ALIGN="LEFT">&nbsp;</TD>
     <TD WIDTH="11%" ALIGN="RIGHT"></TD>
        <TD WIDTH="3%" ALIGN="LEFT">&nbsp;</TD>
     <TD WIDTH="12%" ALIGN="RIGHT"></TD>
        <TD WIDTH="6%" ALIGN="LEFT">&nbsp;</TD></TR>
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     <TD ALIGN="LEFT"><FONT SIZE=2>Common Stock, $0.01 par value</FONT></TD>
        <TD ALIGN="LEFT">&nbsp;</TD>
     <TD ALIGN="RIGHT"><FONT SIZE=2>1,600,000 shares</FONT></TD>
        <TD ALIGN="LEFT"><FONT SIZE=2>&nbsp;</FONT></TD>
     <TD ALIGN="RIGHT"><FONT SIZE=2>$26.375</FONT></TD>
        <TD ALIGN="LEFT"><FONT SIZE=2>&nbsp;</FONT></TD>
     <TD ALIGN="RIGHT"><FONT SIZE=2>$42,200,000</FONT></TD>
        <TD ALIGN="LEFT"><FONT SIZE=2>&nbsp;</FONT></TD>
     <TD ALIGN="RIGHT"><FONT SIZE=2>$11,140.80</FONT></TD>
        <TD ALIGN="LEFT"><FONT SIZE=2>&nbsp;</FONT></TD></TR>
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<TD WIDTH=3%><FONT SIZE=1>(1) </FONT></TD>
<TD WIDTH=3%><FONT SIZE=1></FONT></TD>
<TD WIDTH=94%><FONT SIZE=1>This Registration Statement shall also cover any additional shares of Common Stock which
become issuable under the 1991 Stock Option Plan by reason of any stock dividend, stock
split, recapitalization or other similar transaction effected without the Registrant&#146;s
receipt of consideration which results in an increase in the number of the outstanding
shares of Registrant&#146;s Common Stock. </FONT> </TD>
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<TD WIDTH=3%><FONT SIZE=1>(2) </FONT></TD>
<TD WIDTH=3%><FONT SIZE=1></FONT></TD>
<TD WIDTH=94%><FONT SIZE=1>Calculated solely for purposes of this offering under Rule 457(h) of the Securities Act of 1933, as
amended, on the basis of the average of the high and low selling prices per share of Registrant&#146;s Common Stock on June 15,
2000, as reported by the Nasdaq National Market. </FONT> </TD></TR>
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<H1 ALIGN=CENTER><FONT SIZE=2>PART II</FONT></H1>

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<H1 ALIGN=CENTER><FONT SIZE=2>Information Required in the Registration Statement</FONT></H1>

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<H2 ALIGN=LEFT><FONT SIZE=2>Item 3. Incorporation of Documents by Reference</FONT></H2>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;BioCryst Pharmaceuticals, Inc. (the
&#147;Registrant&#148;) hereby incorporates by reference into this Registration Statement the
following documents previously filed with the Securities and Exchange Commission (the
&#147;Commission&#148;): </FONT></P>

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(a)
The Registrant&#146;s Annual Report on Form 10-K filed with the Commission on March 27, 2000
for the fiscal year ending December 31, 1999;</FONT></TD>
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(b)
The Registrant&#146;s Quarterly Report on Form 10-Q filed with the Commission on May 9, 2000
for the period ending March 31, 2000; and</FONT></TD>
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(c)
The Registrant&#146;s Registration Statement No. 0-23186 on Form 8-A filed with the Commission
on January 7, 1994, together with the amendment thereto filed with the Commission on
March 14, 1994 pursuant to Section 12 of the Securities Exchange Act of 1934, as amended,
(the &#147;1934 Act&#148;) in which are described the terms, rights and provisions applicable to
the Registrant&#146;s outstanding Common Stock.</FONT></TD>
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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All reports and definitive proxy or
information statements filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the 1934
Act after the date of this Registration Statement and prior to the filing of a
post-effective amendment which indicates that all securities offered hereby have been
sold or which de-registers all securities then remaining unsold shall be deemed to be
incorporated by reference into this Registration Statement and to be a part hereof from
the date of filing of such documents. Any statement contained in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified or
superseded for purposes of this Registration Statement to the extent that a statement
contained herein or in any subsequently filed document which also is deemed to be
incorporated by reference herein modifies or supersedes such statement. Any such
statement so modified or superseded shall not be deemed, except as so modified or
superseded, to constitute a part of this Registration Statement. </FONT></P>

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<H2 ALIGN=LEFT><FONT SIZE=2>Item 4. Description of Securities </FONT></H2>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable. </FONT></P>

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<H2 ALIGN=LEFT><FONT SIZE=2>Item 5. Interests of Named Experts and Counsel </FONT></H2>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable. </FONT></P>

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<H2 ALIGN=LEFT><FONT SIZE=2>Item 6. Indemnification of Directors and Officers </FONT></H2>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section 145 of the Delaware law empowers a
corporation to indemnify its directors and officers and to purchase insurance with
respect to liability arising out of their capacity or status as directors and officers,
but this statutory provision does not eliminate or limit the liability of a director: for
any breach of the director&#146;s duty of loyalty to the corporation or its stockholders; for
acts or omissions not in good faith or which involve intentional misconduct or a knowing
violation of law; arising under Section 174 of the Delaware law; or for any transaction
from which the director derived an improper personal benefit. </FONT></P>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant&#146;s certificate of
incorporation provides that directors will not be personally liable to the Registrant or
its stockholders for monetary damages for any breach of fiduciary duty as directors of
the Registrant to the maximum extent permitted by Delaware law. </FONT></P>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Delaware law provides further that the
indemnification permitted thereunder shall not be deemed exclusive of any other rights to
which the directors and officers may be entitled under the corporation&#146;s bylaws, or by
reason of any agreement, a vote of stockholders or otherwise. The Registrant&#146;s
certificate of incorporation provides that the Registrant indemnify any person who was or
is a party or is threatened to be made a party to any threatened, pending or completed
action, suit or proceeding by reason of the fact that the person is or was a director or
officer, or is or was serving at the Registrant&#146;s request as a director or officer of
another corporation, partnership, joint venture, trust, employee benefit plan or other
enterprise, against expenses, judgements, fines and amounts paid in settlement actually
and reasonably incurred by the person in the action, suit or proceeding. </FONT></P>

<P ALIGN=CENTER><FONT SIZE=2>II-1 </FONT></P>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registrant has obtained directors&#146; and
officers&#146; liability insurance. </FONT></P>

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<H2 ALIGN=LEFT><FONT SIZE=2>Item 7. Exemption from Registration Claimed </FONT></H2>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not Applicable. </FONT></P>

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<H2 ALIGN=LEFT><FONT SIZE=2>Item 8. Exhibits </FONT></H2>

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<TD WIDTH=3% COLSPAN=2><FONT SIZE=2><I><U>Exhibit Number</U></I></FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE="2"><I><U>Exhibit</U></I></FONT></TD>
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<TD><FONT SIZE=2>&nbsp;</FONT></TD></tr>
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<TD WIDTH=3%><FONT SIZE=2>4 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>Instruments
Defining the Rights of Stockholders. Reference is made to Registrant&#146;s Registration
Statement No. 0-23186 on Form 8-A, together with any exhibits thereto, which are
incorporated herein by reference pursuant to Item 3(c) to this Registration Statement.</FONT></TD>
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<TD WIDTH=3%><FONT SIZE=2>5 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>Opinion and consent of Brobeck, Phleger &amp; Harrison LLP. </FONT></TD>
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<TD WIDTH=3%><FONT SIZE=2>23.1 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>Consent of Ernst &amp; Young LLP, Independent Auditors.</FONT></TD>
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<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=3%><FONT SIZE=2>23.2 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>Consent of Brobeck, Phleger &amp; Harrison LLP is contained in Exhibit 5.</FONT></TD>
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<TD WIDTH=3%><FONT SIZE=2>24 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>Power of Attorney. Reference is made to page II-4 of this Registration Statement.</FONT></TD>
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<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=3%><FONT SIZE=2>99.1 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>1991 Stock Option Plan.</FONT></TD>
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<H2 ALIGN=LEFT><FONT SIZE=2> Item 9. Undertakings </FONT></H2>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. The undersigned Registrant hereby
undertakes: (1) to file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement: (i) to include any prospectus
required by Section 10(a)(3) of the 1933 Act, (ii) to reflect in the prospectus any facts
or events arising after the effective date of this Registration Statement (or the most
recent post-effective amendment thereof) which, individually or in the aggregate,
represent a fundamental change in the information set forth in this Registration
Statement and (iii) to include any material information with respect to the plan of
distribution not previously disclosed in this Registration Statement or any material
change to such information in this Registration Statement; provided, however, that
clauses (1)(i) and (1)(ii) shall not apply if the information required to be included in
a post-effective amendment by those clauses is contained in periodic reports filed by the
Registrant pursuant to Section 13 or Section 15(d) of the 1934 Act that are incorporated
by reference into this Registration Statement; (2) that for the purpose of determining
any liability under the 1933 Act each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein and the offering
of such securities at that time shall be deemed to be the initial bona fide offering
thereof; and (3) to remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of the
Registrant&#146;s 1991 Stock Option Plan. </FONT></P>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. The undersigned Registrant hereby
undertakes that, for purposes of determining any liability under the 1933 Act, each
filing of the Registrant&#146;s annual report pursuant to Section 13(a) or Section 15(d) of
the 1934 Act that is incorporated by reference into this Registration Statement shall be
deemed to be a new registration statement relating to the securities offered therein, and
the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof. </FONT></P>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C. Insofar as indemnification for
liabilities arising under the 1933 Act may be permitted to directors, officers or
controlling persons of the Registrant pursuant to the indemnification provisions
summarized in Item 6 or otherwise, the Registrant has been advised that, in the opinion
of the Commission, such indemnification is against public policy as expressed in the 1933
Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses incurred
or paid by a director, officer, or controlling person of the Registrant in the successful
defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the Registrant
will, unless in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the 1933 Act and will be
governed by the final adjudication of such issue. </FONT></P>

<P ALIGN=CENTER><FONT SIZE=2>II-2 </FONT></P>

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<H1 ALIGN=CENTER><FONT SIZE=2>SIGNATURES</FONT></H1>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the
Securities Act of 1933, as amended, the Registrant certifies that it has reasonable
grounds to believe that it meets all of the requirements for filing on Form S-8, and has
duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Birmingham, State of Alabama on this 15th day
of June, 2000. </FONT></P>

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<TD WIDTH=50% Align=Left><FONT SIZE="2"><B>BIOCRYST PHARMACEUTICALS, INC.</B></FONT></TD></TR>
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<TD WIDTH=45%><FONT SIZE=2></FONT></TD>
<TD WIDTH=5% align=left><FONT SIZE="2">By: <BR></FONT></TD>
<TD WIDTH=50% align=left><FONT SIZE="2"><U>/s/ Charles E. Bugg</U><BR>Charles E. Bugg, Ph.D.<BR>Chief Executive Officer</FONT></TD>
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<H1 ALIGN=CENTER><FONT SIZE="2"><U>POWER OF ATTORNEY</U></FONT></H1>

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<P><FONT SIZE="2"><B>KNOW ALL PERSONS BY THESE PRESENTS:</B></FONT> </P>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;That the undersigned officers and directors
of BioCryst Pharmaceuticals, Inc., a Delaware corporation, do hereby constitute and
appoint Charles E. Bugg, Ph.D. and W. Randall Pittman, and each of them, the lawful
attorneys-in-fact and agents with full power and authority to do any and all acts and
things and to execute any and all instruments which said attorneys and agents, and any
one of them, determine may be necessary or advisable or required to enable said
corporation to comply with the Securities Act of 1933, as amended, and any rules or
regulations or requirements of the Securities and Exchange Commission in connection with
this Registration Statement. Without limiting the generality of the foregoing power and
authority, the powers granted include the power and authority to sign the names of the
undersigned officers and directors in the capacities indicated below to this Registration
Statement, to any and all amendments, both pre-effective and post-effective, and
supplements to this Registration Statement, and to any and all instruments or documents
filed as part of or in conjunction with this Registration Statement or amendments or
supplements thereof, and each of the undersigned hereby ratifies and confirms that all
said attorneys and agents, or any one of them, shall do or cause to be done by virtue
hereof. This Power of Attorney may be signed in several counterparts. </FONT></P>

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<P><FONT SIZE="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>IN WITNESS WHEREOF</B>, each of the undersigned
has executed this Power of Attorney as of the date indicated.</FONT> </P>

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<P><FONT SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the
Securities Act of 1933, as amended, this Registration Statement has been signed below by
the following persons in the capacities and on the dates indicated. </FONT></P>
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<TH><FONT SIZE=1>Signature</FONT><HR WIDTH=95% SIZE=1 NOSHADE></TH>
<TH><FONT SIZE=1>Title</FONT><HR WIDTH=95% SIZE=1 NOSHADE></TH>
<TH><FONT SIZE=1>Date</FONT><HR WIDTH=95% SIZE=1 NOSHADE></TH></TR>

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<TD WIDTH=30% ALIGN=left><FONT SIZE="2"><U>/s/ Charles E. Bugg&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
Charles E. Bugg, Ph.D.</FONT></TD>
<TD WIDTH=45% ALIGN=CENTER><FONT SIZE=2>Chairman, Chief Executive Officer and<BR>Director (Principal Executive Officer)</FONT></TD>
<TD WIDTH=30% ALIGN=CENTER><FONT SIZE=2>June 15, 2000</FONT></TD></TR>
<TR VALIGN=TOP>
<TR>
<TD>&nbsp;</TD></TR>
<TR VALIGN=TOP>
<TD WIDTH=30% ALIGN=left><FONT SIZE="2"><U>/s/ W. Randall Pittman&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>W. Randall Pittman</FONT></TD>
<TD WIDTH=45% ALIGN=CENTER><FONT SIZE=2>Chief Financial Officer, Treasurer and<BR>Assistant Secretary<BR>(Principal Financial and Accounting Officer)</FONT></TD>
<TD WIDTH=30% ALIGN=CENTER><FONT SIZE=2>June 15, 2000</FONT></TD></TR>
<TR>
<TD>&nbsp;</TD></TR>
<TR VALIGN=TOP>
<TD WIDTH=30% ALIGN=left><FONT SIZE="2"><U>/s/ J. Claude Bennett&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>J. Claude Bennett, M.D.</FONT></TD>
<TD WIDTH=45% ALIGN=CENTER><FONT SIZE=2>President, Chief Operating Officer and<BR>Director</FONT></TD>
<TD WIDTH=30% ALIGN=CENTER><FONT SIZE=2>June 15, 2000</FONT></TD></TR>
<TR>
<TD>&nbsp;</TD></TR>
</TABLE>

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<P ALIGN=CENTER><FONT SIZE=2>II-4 </FONT></P>

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<BR><BR>

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<TH><FONT SIZE=1>Signature</FONT><HR WIDTH=95% SIZE=1 NOSHADE></TH>
<TH><FONT SIZE=1>Title</FONT><HR WIDTH=95% SIZE=1 NOSHADE></TH>
<TH><FONT SIZE=1>Date</FONT><HR WIDTH=95% SIZE=1 NOSHADE></TH></TR>
<TR VALIGN=TOP>
<TD WIDTH=30% ALIGN=left><FONT SIZE="2"><U>/s/ John A. Montgomery</U><BR>John A. Montgomery, Ph.D.<BR></FONT></TD>
<TD WIDTH=45% ALIGN=CENTER><FONT SIZE=2>Senior Vice President, Secretary, Chief<BR>Scientific Officer and Director</FONT></TD>
<TD WIDTH=30% ALIGN=CENTER><FONT SIZE=2>June 15, 2000</FONT></TD></TR>
<TR VALIGN=TOP>
<TR>
<TD>&nbsp;</TD></TR>
<TR VALIGN=TOP>
<TD WIDTH=30% ALIGN=left><FONT SIZE="2"><U>/s/ Edwin A. Gee</U><BR>Edwin A. Gee, Ph.D.<BR></FONT></TD>
<TD WIDTH=45% ALIGN=CENTER><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30% ALIGN=CENTER><FONT SIZE=2>June 15, 2000</FONT></TD></TR>
<TR>
<TD>&nbsp;</TD></TR>
<TR VALIGN=TOP>
<TD WIDTH=30% ALIGN=left><FONT SIZE="2"><U>/s/ Zola P. Horovitz</U><BR>Zola P. Horovitz, Ph.D.<BR></FONT></TD>
<TD WIDTH=45% ALIGN=CENTER><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30% ALIGN=CENTER><FONT SIZE=2>June 15, 2000 </FONT></TD></TR>
<TR>
<TD>&nbsp;</TD></TR>
<TR VALIGN=TOP>
<TD WIDTH=30% ALIGN=left><FONT SIZE="2"><U>/s/ Randolph C. Steer</U><BR>Randolph C. Steer, M.D., Ph.D.</FONT></TD>
<TD WIDTH=45% ALIGN=CENTER><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30% ALIGN=CENTER><FONT SIZE=2>June 15, 2000</FONT></TD></TR>
<TR>
<TD>&nbsp;</TD></TR>
<TR VALIGN=TOP>
<TD WIDTH=30% ALIGN=left><FONT SIZE="2"><U>/s/ William M. Spencer, III</U><BR>William M. Spencer, III</FONT></TD>
<TD WIDTH=45% ALIGN=CENTER><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30% ALIGN=CENTER><FONT SIZE=2>June 15, 2000</FONT></TD></TR>
<TR>
<TD>&nbsp;</TD></TR>
<TR VALIGN=TOP>
<TD WIDTH=30% ALIGN=left><FONT SIZE="2"><U>/s/ William W. Featheringill</U><BR>William W. Featheringill</FONT></TD>
<TD WIDTH=45% ALIGN=CENTER><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30% ALIGN=CENTER><FONT SIZE=2>June 15, 2000</FONT></TD></TR>
<TR>
<TD>&nbsp;</TD></TR>
<TR VALIGN=TOP>
<TD WIDTH=30% ALIGN=left><FONT SIZE="2"><U>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>Joseph H. Sherrill, Jr.</FONT></TD>
<TD WIDTH=45% ALIGN=CENTER><FONT SIZE=2>Director</FONT></TD>
<TD WIDTH=30% ALIGN=CENTER><FONT SIZE=2>June 15, 2000</FONT></TD></TR>
<TR>
<TD>&nbsp;</TD></TR>
</TABLE>
<BR>


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<P ALIGN=CENTER><FONT SIZE=2> SECURITIES AND EXCHANGE COMMISSION<BR>&nbsp;<BR>
    WASHINGTON, D.C. 20549 </FONT></P>

<BR>
<BR>
<!-- MARKER FORMAT-SHEET="Para Center 10" -->
<P ALIGN=CENTER><FONT SIZE=2> EXHIBITS<BR>&nbsp;<BR>
TO<BR>
&nbsp;<BR>
FORM S-8<BR>
&nbsp;<BR>
UNDER<BR>
&nbsp;<BR>
SECURITIES ACT OF 1933 </FONT></P>
<BR>
<BR>
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<H1 ALIGN=CENTER><FONT SIZE=2>BIOCRYST PHARMACEUTICALS, INC.</FONT></H1>



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<H1 ALIGN=CENTER><FONT SIZE=2>EXHIBIT INDEX</FONT></H1>

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<TABLE WIDTH=600 CELLPADDING=0 CELLSPACING=0>
<TR VALIGN=TOP>
<TD WIDTH=3% COLSPAN=2><FONT SIZE=2><I><U>Exhibit Number</U></I></FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE="2"><I><U>Exhibit</U></I></FONT></TD>
</TR>
<TR VALIGN=TOP>
<TD WIDTH=3%>&nbsp;</TD></tr>
<TR VALIGN=TOP>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=3%><FONT SIZE=2>4 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>Instruments
Defining the Rights of Stockholders. Reference is made to Registrant&#146;s Registration
Statement No. 0-23186 on Form 8-A, together with any exhibits thereto, which are
incorporated herein by reference pursuant to Item 3(c) to this Registration Statement.</FONT></TD>
</TR>
<TR VALIGN=TOP>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=3%><FONT SIZE=2>5 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>Opinion and consent of Brobeck, Phleger &amp; Harrison LLP. </FONT></TD>
</TR>
<TR VALIGN=TOP>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=3%><FONT SIZE=2>23.1 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>Consent of Ernst &amp; Young LLP, Independent Auditors.</FONT></TD>
</TR>
<TR VALIGN=TOP>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=3%><FONT SIZE=2>23.2 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>Consent of Brobeck, Phleger &amp; Harrison LLP is contained in Exhibit 5.</FONT></TD>
</TR>
<TR VALIGN=TOP>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=3%><FONT SIZE=2>24 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>Power of Attorney. Reference is made to page II-4 of this Registration Statement.</FONT></TD>
</TR>
<TR VALIGN=TOP>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=3%><FONT SIZE=2>99.1 </FONT></TD>
<TD WIDTH=3%><FONT SIZE=2></FONT></TD>
<TD WIDTH=91%><FONT SIZE=2>1991 Stock Option Plan.</FONT></TD>
</TR>
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{"company-data": {"conformed-name": "BIOCRYST PHARMACEUTICALS INC", "cik": "0000882796", "assigned-sic": "2836", "irs-number": "621413174", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-39484", "film-number": "656389"}, "business-address": {"street1": "2190 PKWY LAKE DR", "city": "BIRMINGHAM", "state": "AL", "zip": "35244", "phone": "2054444600"}, "mail-address": {"street1": "2190 PARKWAY LAKE DR", "city": "BIRMINGHAM", "state": "AL", "zip": "35244"}}
Form S-8
As filed with the Securities and Exchange
Commission on June 16, 2000
Registration No. 333-____________
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
BIOCRYST PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)
Delaware
(State or other jurisdiction
of incorporation or organization)
62-1413174
(IRS Employer Identification No.)
2190 Parkway Lake Drive
Birmingham, Alabama 35244
(Address of principal executive offices) (Zip Code)
1991 STOCK OPTION PLAN
(Amended and Restated as of March 6, 2000)
(Full title of the Plan)
Charles E. Bugg, Ph.D.
Chairman and Chief Executive Officer
BioCryst Pharmaceuticals
2190 Parkway Lake Drive
Birmingham, Alabama 35244
(Name and address of agent for service)
(205) 444-4600
(Telephone number, including area code, of agent for service)
CALCULATION OF REGISTRATION FEE
Title of Securities to be
Registered
Amount to be
Registered(1)
Proposed
Maximum Offering
Price per Share(2)
Proposed
Maximum Aggregate
Offering Price(2)
Amount of
Registration Fee
1991 Stock Option Plan
Common Stock, $0.01 par value
1,600,000 shares
$26.375
$42,200,000
$11,140.80
(1)
This Registration Statement shall also cover any additional shares of Common Stock which
become issuable under the 1991 Stock Option Plan by reason of any stock dividend, stock
split, recapitalization or other similar transaction effected without the Registrant's
receipt of consideration which results in an increase in the number of the outstanding
shares of Registrant's Common Stock.
(2)
Calculated solely for purposes of this offering under Rule 457(h) of the Securities Act of 1933, as
amended, on the basis of the average of the high and low selling prices per share of Registrant's Common Stock on June 15,
2000, as reported by the Nasdaq National Market.
PART II
Information Required in the Registration Statement
Item 3. Incorporation of Documents by Reference
BioCryst Pharmaceuticals, Inc. (the
"Registrant") hereby incorporates by reference into this Registration Statement the
following documents previously filed with the Securities and Exchange Commission (the
"Commission"):
(a)
The Registrant's Annual Report on Form 10-K filed with the Commission on March 27, 2000
for the fiscal year ending December 31, 1999;
(b)
The Registrant's Quarterly Report on Form 10-Q filed with the Commission on May 9, 2000
for the period ending March 31, 2000; and
(c)
The Registrant's Registration Statement No. 0-23186 on Form 8-A filed with the Commission
on January 7, 1994, together with the amendment thereto filed with the Commission on
March 14, 1994 pursuant to Section 12 of the Securities Exchange Act of 1934, as amended,
(the "1934 Act") in which are described the terms, rights and provisions applicable to
the Registrant's outstanding Common Stock.
All reports and definitive proxy or
information statements filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the 1934
Act after the date of this Registration Statement and prior to the filing of a
post-effective amendment which indicates that all securities offered hereby have been
sold or which de-registers all securities then remaining unsold shall be deemed to be
incorporated by reference into this Registration Statement and to be a part hereof from
the date of filing of such documents. Any statement contained in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified or
superseded for purposes of this Registration Statement to the extent that a statement
contained herein or in any subsequently filed document which also is deemed to be
incorporated by reference herein modifies or supersedes such statement. Any such
statement so modified or superseded shall not be deemed, except as so modified or
superseded, to constitute a part of this Registration Statement.
Item 4. Description of Securities
Not Applicable.
Item 5. Interests of Named Experts and Counsel
Not Applicable.
Item 6. Indemnification of Directors and Officers
Section 145 of the Delaware law empowers a
corporation to indemnify its directors and officers and to purchase insurance with
respect to liability arising out of their capacity or status as directors and officers,
but this statutory provision does not eliminate or limit the liability of a director: for
any breach of the director's duty of loyalty to the corporation or its stockholders; for
acts or omissions not in good faith or which involve intentional misconduct or a knowing
violation of law; arising under Section 174 of the Delaware law; or for any transaction
from which the director derived an improper personal benefit.
The Registrant's certificate of
incorporation provides that directors will not be personally liable to the Registrant or
its stockholders for monetary damages for any breach of fiduciary duty as directors of
the Registrant to the maximum extent permitted by Delaware law.
The Delaware law provides further that the
indemnification permitted thereunder shall not be deemed exclusive of any other rights to
which the directors and officers may be entitled under the corporation's bylaws, or by
reason of any agreement, a vote of stockholders or otherwise. The Registrant's
certificate of incorporation provides that the Registrant indemnify any person who was or
is a party or is threatened to be made a party to any threatened, pending or completed
action, suit or proceeding by reason of the fact that the person is or was a director or
officer, or is or was serving at the Registrant's request as a director or officer of
another corporation, partnership, joint venture, trust, employee benefit plan or other
enterprise, against expenses, judgements, fines and amounts paid in settlement actually
and reasonably incurred by the person in the action, suit or proceeding.
II-1
The Registrant has obtained directors' and
officers' liability insurance.
Item 7. Exemption from Registration Claimed
Not Applicable.
Item 8. Exhibits
Exhibit Number
Exhibit
4
Instruments
Defining the Rights of Stockholders. Reference is made to Registrant's Registration
Statement No. 0-23186 on Form 8-A, together with any exhibits thereto, which are
incorporated herein by reference pursuant to Item 3(c) to this Registration Statement.
5
Opinion and consent of Brobeck, Phleger & Harrison LLP.
23.1
Consent of Ernst & Young LLP, Independent Auditors.
23.2
Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5.
24
Power of Attorney. Reference is made to page II-4 of this Registration Statement.
99.1
1991 Stock Option Plan.
Item 9. Undertakings
A. The undersigned Registrant hereby
undertakes: (1) to file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement: (i) to include any prospectus
required by Section 10(a)(3) of the 1933 Act, (ii) to reflect in the prospectus any facts
or events arising after the effective date of this Registration Statement (or the most
recent post-effective amendment thereof) which, individually or in the aggregate,
represent a fundamental change in the information set forth in this Registration
Statement and (iii) to include any material information with respect to the plan of
distribution not previously disclosed in this Registration Statement or any material
change to such information in this Registration Statement; provided, however, that
clauses (1)(i) and (1)(ii) shall not apply if the information required to be included in
a post-effective amendment by those clauses is contained in periodic reports filed by the
Registrant pursuant to Section 13 or Section 15(d) of the 1934 Act that are incorporated
by reference into this Registration Statement; (2) that for the purpose of determining
any liability under the 1933 Act each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein and the offering
of such securities at that time shall be deemed to be the initial bona fide offering
thereof; and (3) to remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of the
Registrant's 1991 Stock Option Plan.
B. The undersigned Registrant hereby
undertakes that, for purposes of determining any liability under the 1933 Act, each
filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of
the 1934 Act that is incorporated by reference into this Registration Statement shall be
deemed to be a new registration statement relating to the securities offered therein, and
the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof.
C. Insofar as indemnification for
liabilities arising under the 1933 Act may be permitted to directors, officers or
controlling persons of the Registrant pursuant to the indemnification provisions
summarized in Item 6 or otherwise, the Registrant has been advised that, in the opinion
of the Commission, such indemnification is against public policy as expressed in the 1933
Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses incurred
or paid by a director, officer, or controlling person of the Registrant in the successful
defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the Registrant
will, unless in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the 1933 Act and will be
governed by the final adjudication of such issue.
II-2
SIGNATURES
Pursuant to the requirements of the
Securities Act of 1933, as amended, the Registrant certifies that it has reasonable
grounds to believe that it meets all of the requirements for filing on Form S-8, and has
duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Birmingham, State of Alabama on this 15th day
of June, 2000.
BIOCRYST PHARMACEUTICALS, INC.
By:
/s/ Charles E. Bugg
Charles E. Bugg, Ph.D.
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS:
That the undersigned officers and directors
of BioCryst Pharmaceuticals, Inc., a Delaware corporation, do hereby constitute and
appoint Charles E. Bugg, Ph.D. and W. Randall Pittman, and each of them, the lawful
attorneys-in-fact and agents with full power and authority to do any and all acts and
things and to execute any and all instruments which said attorneys and agents, and any
one of them, determine may be necessary or advisable or required to enable said
corporation to comply with the Securities Act of 1933, as amended, and any rules or
regulations or requirements of the Securities and Exchange Commission in connection with
this Registration Statement. Without limiting the generality of the foregoing power and
authority, the powers granted include the power and authority to sign the names of the
undersigned officers and directors in the capacities indicated below to this Registration
Statement, to any and all amendments, both pre-effective and post-effective, and
supplements to this Registration Statement, and to any and all instruments or documents
filed as part of or in conjunction with this Registration Statement or amendments or
supplements thereof, and each of the undersigned hereby ratifies and confirms that all
said attorneys and agents, or any one of them, shall do or cause to be done by virtue
hereof. This Power of Attorney may be signed in several counterparts.
IN WITNESS WHEREOF
, each of the undersigned
has executed this Power of Attorney as of the date indicated.
Pursuant to the requirements of the
Securities Act of 1933, as amended, this Registration Statement has been signed below by
the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Charles E. Bugg
Charles E. Bugg, Ph.D.
Chairman, Chief Executive Officer and
Director (Principal Executive Officer)
June 15, 2000
/s/ W. Randall Pittman
W. Randall Pittman
Chief Financial Officer, Treasurer and
Assistant Secretary
(Principal Financial and Accounting Officer)
June 15, 2000
/s/ J. Claude Bennett
J. Claude Bennett, M.D.
President, Chief Operating Officer and
Director
June 15, 2000
II-4
Signature
Title
Date
/s/ John A. Montgomery
John A. Montgomery, Ph.D.
Senior Vice President, Secretary, Chief
Scientific Officer and Director
June 15, 2000
/s/ Edwin A. Gee
Edwin A. Gee, Ph.D.
Director
June 15, 2000
/s/ Zola P. Horovitz
Zola P. Horovitz, Ph.D.
Director
June 15, 2000
/s/ Randolph C. Steer
Randolph C. Steer, M.D., Ph.D.
Director
June 15, 2000
/s/ William M. Spencer, III
William M. Spencer, III
Director
June 15, 2000
/s/ William W. Featheringill
William W. Featheringill
Director
June 15, 2000
Joseph H. Sherrill, Jr.
Director
June 15, 2000
II-5
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
EXHIBITS
TO
FORM S-8
UNDER
SECURITIES ACT OF 1933
BIOCRYST PHARMACEUTICALS, INC.
EXHIBIT INDEX
Exhibit Number
Exhibit
4
Instruments
Defining the Rights of Stockholders. Reference is made to Registrant's Registration
Statement No. 0-23186 on Form 8-A, together with any exhibits thereto, which are
incorporated herein by reference pursuant to Item 3(c) to this Registration Statement.
5
Opinion and consent of Brobeck, Phleger & Harrison LLP.
23.1
Consent of Ernst & Young LLP, Independent Auditors.
23.2
Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5.
24
Power of Attorney. Reference is made to page II-4 of this Registration Statement.
99.1
1991 Stock Option Plan.