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<P align="right"><FONT size="3">As filed with the Securities and
Exchange Commission on April&nbsp;10, 2003<BR>
Registration No.&nbsp;333-</FONT>

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<P align="center"><FONT size="4"><B>SECURITIES AND EXCHANGE COMMISSION</B>
</FONT>

<DIV align="center"><FONT size="3"><B>Washington, D.C. 20549</B>
</FONT>
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<P align="center"><FONT size="5"><B>FORM S-8<BR>
REGISTRATION STATEMENT</B>
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<DIV align="center"><FONT size="2"><B><I>Under<BR>
The Securities Act of 1933</I></B>
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<P align="center"><FONT size="6"><B>ISTA PHARMACEUTICALS, INC.</B>
</FONT>

<DIV align="center"><FONT size="2"><B>(Exact name of Registrant as specified in its charter)</B>
</FONT>
</DIV>

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    <TD width="34%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="30%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="30%">&nbsp;</TD>
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<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2"><B>Delaware<br>
(State or other jurisdiction of<br>
incorporation or organization)</B></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
<B>ISTA Pharmaceuticals, Inc.<br>
15279 Alton Parkway, Building 100<br>
Irvine, CA 92618<br>
(949)&nbsp;788-6000</B>
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2"><B>33-0511729<br>
(I.R.S. Employer<br>
Identification Number)</B></FONT></TD>
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<DIV align="center"><FONT size="1"><B>(Address, including zip code, and telephone number, including area code, of Registrant&#146;s principal executive offices)</B>
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<P align="center"><FONT size="2"><B>2000 STOCK PLAN</B>
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<P align="center"><FONT size="2"><B>Vicente Anido, Jr., Ph.D.<BR>
President and Chief Executive Officer<BR>
ISTA Pharmaceuticals, Inc.<BR>
15279 Alton Parkway, Building 100<BR>
Irvine, CA 92618<BR>
(949)&nbsp;788-6000</B>
</FONT>

<DIV align="center"><FONT size="1"><B>(Name, address, including zip code, and telephone number, including area code, of agent for service)</B>
</FONT>
</DIV>

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<P align="center"><FONT size="2"><I>Copy to:</I><BR>
<B>Robert C. Funsten<BR>
Stradling Yocca Carlson &#038; Rauth<BR>
a Professional Corporation<BR>
660 Newport Center Drive, Suite&nbsp;1600<BR>
Newport Beach, CA 92660<BR>
(949)&nbsp;725-4000</B><BR>
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<P align="center"><FONT size="2">CALCULATION OF REGISTRATION FEE
</FONT>

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    <TD width="5%">&nbsp;</TD>
    <TD width="4%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="4%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="8%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="9%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
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    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed Maximum</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Title of Securities to</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Amount to be</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>be Registered</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Registered</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Per Share</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Fee</B></FONT></TD>
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    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
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    <TD valign="top"><FONT size="2">Common Stock<BR>
&nbsp;&nbsp;&nbsp;$0.001 par value</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="bottom"><FONT size="2">
199,321 shares (1)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right" valign="bottom"><FONT size="2">$</FONT></TD>
    <TD align="right" valign="bottom"><FONT size="2">5.28</FONT></TD>
    <TD nowrap valign="bottom"><FONT size="2">(2)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right" valign="bottom"><FONT size="2">$</FONT></TD>
    <TD align="right" valign="bottom"><FONT size="2">1,052,414.80</FONT></TD>
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right" valign="bottom"><FONT size="2">$</FONT></TD>
    <TD align="right" valign="bottom"><FONT size="2">85.14</FONT></TD>
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
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<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Represents 199,321 additional shares authorized to be issued under the 2000
Stock Plan.</FONT></TD>
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<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Estimated in accordance with Rule&nbsp;457(h)(1) under the Securities Act of
1933, as amended, solely for the purpose of calculating the registration fee.</FONT></TD>
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<P align="center"><FONT size="2">EXPLANATORY NOTE
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Registration Statement has been prepared in accordance with General
Instruction E to Form&nbsp;S-8, as amended, and relates to an increase of 199,321
shares of common stock, $0.001 par value per share, of the Company, reserved
for issuance under the Company&#146;s 2000 Stock Plan, authorized pursuant to an
&#147;evergreen&#148; clause increase for the 2003 fiscal year.
</FONT>
<P align="center"><FONT size="2">2</FONT>
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<TR><TD colspan="9"><A HREF="#000">PART II<BR> INFORMATION REQUIRED IN REGISTRATION STATEMENT</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#001">ITEM 8. EXHIBITS.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#002">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">POWER OF ATTORNEY</A></TD></TR>
<TR><TD colspan="9"><A HREF="#004">EXHIBIT INDEX</A></TD></TR>
<TR><TD colspan="9"><A HREF="a89148exv5w1.htm">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="a89148exv23w1.htm">EXHIBIT 23.1</A></TD></TR>
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<P align="center"><FONT size="2">PART II<BR>
INFORMATION REQUIRED IN REGISTRATION STATEMENT
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The contents of the Company&#146;s previously filed Registration Statement on
Form&nbsp;S-8 relating to shares issued under the Company&#146;s 2000 Stock Plan (File
No.&nbsp;333-56042) are hereby incorporated by reference.
</FONT>
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<P align="left"><FONT size="2">ITEM 8. EXHIBITS.
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    <TD nowrap align="center"><FONT size="1"><B>Exhibit</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
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    <TD nowrap align="center"><FONT size="1"><B>Number</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Description of Document</B></FONT></TD>
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    <TD valign="top"><FONT size="2">4.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
2000 Stock Plan (incorporated by reference to Exhibit&nbsp;10.1 of
Registration Statement on Form&nbsp;S-8 filed February&nbsp;18, 2003 (File
No.&nbsp;333-103276).</FONT></TD>
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<TR valign="bottom">
    <TD valign="top"><FONT size="2">5.1*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion re legality of Stradling Yocca Carlson &#038; Rauth, a
Professional Corporation.</FONT></TD>
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    <TD valign="top"><FONT size="2">23.1*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Independent Auditors.</FONT></TD>
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    <TD valign="top"><FONT size="2">23.2*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Counsel (contained in Exhibit&nbsp;5.1).</FONT></TD>
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    <TD valign="top"><FONT size="2">24.1*</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Power of Attorney (see page S-2).</FONT></TD>
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    <TD width="1%" align="left" nowrap><FONT size="2">*</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Filed herewith.</FONT></TD>
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<P align="center"><FONT size="2">3</FONT>
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<P align="center"><FONT size="2">SIGNATURES
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
the registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form&nbsp;S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Irvine, State of California, on April&nbsp;9, 2003.
</FONT>
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By:
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">/s/ Vicente Anido, Jr.<BR>
<HR size="1" noshade><br>
Vicente Anido, Jr., Ph.D.<br>
President and Chief Executive Officer</FONT></TD>
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<P align="center"><FONT size="2">S-1</FONT>
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<P align="center"><FONT size="2">POWER OF ATTORNEY
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Vicente
Anido, Jr., Ph.D., and Lauren P. Silvernail and each of them as his or her
attorneys-in-fact, with full power of substitution, for him or her in any and all
capacities, to sign any amendments to this Registration Statement on Form&nbsp;S-8,
and to file the same, with all exhibits thereto and other documents in
connection therewith, with the Securities and Exchange Commission, hereby
ratifying and confirming all that said attorney-in-fact, or his substitute, may
do or cause to be done by virtue hereof.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement on Form&nbsp;S-8 has been signed by the following
persons in the capacities and on the dates indicated.
</FONT>

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    <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
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<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Vicente Anido, Jr., Ph.D.<BR>
<HR size="1" noshade>
Vicente Anido, Jr., Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
President, Chief Executive
Officer and Director (Principal
Executive Officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 9, 2003</FONT></TD>
</TR>
<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Lauren P. Silvernail<BR>
<HR size="1" noshade>
Lauren P. Silvernail</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Chief Financial Officer and Vice
President of Corporate
Development
(Principal Financial and
Accounting Officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 9, 2003</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Robert G. McNeil, Ph.D.<HR size="1" noshade>
Robert G. McNeil, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Chairman of the Board of Directors
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top" nowrap><FONT size="2">April 10, 2003</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Liza Page Nelson<BR>
<HR size="1" noshade>
Liza Page Nelson</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 9, 2003</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Peter Barton Hutt<BR>
<HR size="1" noshade>
Peter Barton Hutt</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 9, 2003</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Kathleen D. LaPorte<BR>
<HR size="1" noshade>
Kathleen D. LaPorte</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 9, 2003</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Benjamin F. McGraw III<BR>
<HR size="1" noshade>
Benjamin F. McGraw III</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 9, 2003</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Richard C. Williams<BR>
<HR size="1" noshade>
Richard C. Williams</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 9, 2003</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Wayne I. Roe<BR>
<HR size="1" noshade>
Wayne I. Roe</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 9, 2003</FONT></TD>
</TR>

<TR><TD>&nbsp;</TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Jeffrey L. Edwards<BR>
<HR size="1" noshade>
Jeffrey L. Edwards</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">April 9, 2003</FONT></TD>
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<P align="center"><FONT size="2">S-2</FONT>
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<P align="center"><FONT size="2">EXHIBIT INDEX
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    <TD nowrap align="center"><FONT size="1"><B>Number</B></FONT></TD>
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2000 Stock Plan (incorporated by reference to Exhibit&nbsp;10.1 of
Registration Statement on Form&nbsp;S-8 filed February&nbsp;18, 2003 (File
No.&nbsp;333-103276).</FONT></TD>
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    <TD valign="top"><FONT size="2">5.1*</FONT></TD>
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Opinion re legality of Stradling Yocca Carlson &#038; Rauth, a
Professional Corporation.</FONT></TD>
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Consent of Independent Auditors.</FONT></TD>
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Consent of Counsel (contained in Exhibit&nbsp;5.1).</FONT></TD>
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    <TD valign="top"><FONT size="2">24.1*</FONT></TD>
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Power of Attorney (see page S-2).</FONT></TD>
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<P align="center"><FONT size="2">S-3</FONT>


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ISTA Pharmaceuticals Inc
Table of Contents
As filed with the Securities and
Exchange Commission on April 10, 2003
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
ISTA PHARMACEUTICALS, INC.
(Exact name of Registrant as specified in its charter)
Delaware
(State or other jurisdiction of
incorporation or organization)
ISTA Pharmaceuticals, Inc.
15279 Alton Parkway, Building 100
Irvine, CA 92618
(949) 788-6000
33-0511729
(I.R.S. Employer
Identification Number)
(Address, including zip code, and telephone number, including area code, of Registrant's principal executive offices)
2000 STOCK PLAN
Vicente Anido, Jr., Ph.D.
President and Chief Executive Officer
ISTA Pharmaceuticals, Inc.
15279 Alton Parkway, Building 100
Irvine, CA 92618
(949) 788-6000
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copy to:
Robert C. Funsten
Stradling Yocca Carlson & Rauth
a Professional Corporation
660 Newport Center Drive, Suite 1600
Newport Beach, CA 92660
(949) 725-4000
CALCULATION OF REGISTRATION FEE
Proposed Maximum
Proposed Maximum
Amount of
Title of Securities to
Amount to be
Offering Price
Aggregate
Registration
be Registered
Registered
Per Share
Offering Price
Fee
Common Stock
$0.001 par value
199,321 shares (1)
$
5.28
(2)
$
1,052,414.80
$
85.14
(1)
Represents 199,321 additional shares authorized to be issued under the 2000
Stock Plan.
(2)
Estimated in accordance with Rule 457(h)(1) under the Securities Act of
1933, as amended, solely for the purpose of calculating the registration fee.
Table of Contents
EXPLANATORY NOTE
This Registration Statement has been prepared in accordance with General
Instruction E to Form S-8, as amended, and relates to an increase of 199,321
shares of common stock, $0.001 par value per share, of the Company, reserved
for issuance under the Company's 2000 Stock Plan, authorized pursuant to an
"evergreen" clause increase for the 2003 fiscal year.
2
TABLE OF CONTENTS
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
ITEM 8. EXHIBITS.
SIGNATURES
POWER OF ATTORNEY
EXHIBIT INDEX
EXHIBIT 5.1
EXHIBIT 23.1
Table of Contents
PART II
INFORMATION REQUIRED IN REGISTRATION STATEMENT
The contents of the Company's previously filed Registration Statement on
Form S-8 relating to shares issued under the Company's 2000 Stock Plan (File
No. 333-56042) are hereby incorporated by reference.
ITEM 8. EXHIBITS.
Exhibit
Number
Description of Document
4.1
2000 Stock Plan (incorporated by reference to Exhibit 10.1 of
Registration Statement on Form S-8 filed February 18, 2003 (File
No. 333-103276).
5.1*
Opinion re legality of Stradling Yocca Carlson & Rauth, a
Professional Corporation.
23.1*
Consent of Independent Auditors.
23.2*
Consent of Counsel (contained in Exhibit 5.1).
24.1*
Power of Attorney (see page S-2).
*
Filed herewith.
3
Table of Contents
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended,
the registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Irvine, State of California, on April 9, 2003.
By:
/s/ Vicente Anido, Jr.
Vicente Anido, Jr., Ph.D.
President and Chief Executive Officer
S-1
Table of Contents
POWER OF ATTORNEY
Each person whose signature appears below constitutes and appoints Vicente
Anido, Jr., Ph.D., and Lauren P. Silvernail and each of them as his or her
attorneys-in-fact, with full power of substitution, for him or her in any and all
capacities, to sign any amendments to this Registration Statement on Form S-8,
and to file the same, with all exhibits thereto and other documents in
connection therewith, with the Securities and Exchange Commission, hereby
ratifying and confirming all that said attorney-in-fact, or his substitute, may
do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement on Form S-8 has been signed by the following
persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Vicente Anido, Jr., Ph.D.
Vicente Anido, Jr., Ph.D.
President, Chief Executive
Officer and Director (Principal
Executive Officer)
April 9, 2003
/s/ Lauren P. Silvernail
Lauren P. Silvernail
Chief Financial Officer and Vice
President of Corporate
Development
(Principal Financial and
Accounting Officer)
April 9, 2003
/s/ Robert G. McNeil, Ph.D.
Robert G. McNeil, Ph.D.
Chairman of the Board of Directors
April 10, 2003
/s/ Liza Page Nelson
Liza Page Nelson
Director
April 9, 2003
/s/ Peter Barton Hutt
Peter Barton Hutt
Director
April 9, 2003
/s/ Kathleen D. LaPorte
Kathleen D. LaPorte
Director
April 9, 2003
/s/ Benjamin F. McGraw III
Benjamin F. McGraw III
Director
April 9, 2003
/s/ Richard C. Williams
Richard C. Williams
Director
April 9, 2003
/s/ Wayne I. Roe
Wayne I. Roe
Director
April 9, 2003
/s/ Jeffrey L. Edwards
Jeffrey L. Edwards
Director
April 9, 2003
S-2
Table of Contents
EXHIBIT INDEX
Exhibit
Number
Description of Document
4.1
2000 Stock Plan (incorporated by reference to Exhibit 10.1 of
Registration Statement on Form S-8 filed February 18, 2003 (File
No. 333-103276).
5.1*
Opinion re legality of Stradling Yocca Carlson & Rauth, a
Professional Corporation.
23.1*
Consent of Independent Auditors.
23.2*
Consent of Counsel (contained in Exhibit 5.1).
24.1*
Power of Attorney (see page S-2).
S-3