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     <!-- Control Number: KE5040                                                           -->
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     <!-- Client Name:    Kendle International Inc.                                        -->
     <!-- Project Name:   Form S-8                                                         -->
     <!-- Firm Name:      KMK                                                              -->
     <TITLE>Form S-8</TITLE>
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<P ALIGN="Center"><FONT FACE="Times New Roman, Times, Serif" SIZE=2>As filed with the
Securities and Exchange Commission on December 1, 2004 </FONT></P>

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<P ALIGN=RIGHT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Registration No. 333- </FONT></P>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>SECURITIES AND
EXCHANGE COMMISSION <BR>Washington, D.C. 20549 </FONT></H1><BR><BR>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>FORM S-8<BR>
REGISTRATION STATEMENT<BR>UNDER<BR>THE SECURITIES ACT OF 1933 </FONT></H1><BR>

<TABLE WIDTH="100%" BORDER="0" CELLPADDING="0" CELLSPACING="0">
<TR VALIGN="TOP">
     <TD WIDTH="34%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>&nbsp;Incorporated <BR>
Under the Laws<BR>
&nbsp;&nbsp;&nbsp;&nbsp;of Ohio </B>
</FONT></TD>
     <TD WIDTH="33%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>&nbsp;KENDLE INTERNATIONAL INC.<BR>
441 VINE STREET, SUITE 700<BR>
&nbsp;&nbsp;CINCINNATI, OHIO 45202  <BR>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(513) 771-8221</B>
</FONT></TD>
     <TD WIDTH="33%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><B>&nbsp;&nbsp;I.R.S. Employer<BR>
Identification No.<BR>
&nbsp;&nbsp;&nbsp;&nbsp;31-1274091</B>
</FONT></TD></TR>
</TABLE>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>2003 DIRECTORS&#146;
COMPENSATION PLAN </FONT></H1>
<BR>
<TABLE WIDTH="100%" BORDER="0" CELLPADDING="0" CELLSPACING="0">
<TR VALIGN="BOTTOM">
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Gary P. Kreider, Esq.<BR>
Keating, Muething &amp; Klekamp, P.L.L.<BR>
One East Fourth Street<BR>
Cincinnati, Ohio 45202<BR>
Phone: (513) 579-6411<BR>
Facsimile (513) 579-6956</FONT><HR WIDTH=90% SIZE=1 COLOR=BLACK NOSHADE></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="2">&nbsp;</FONT></TH></TR>
<TR VALIGN="TOP">
     <TD WIDTH="34%"><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD>
     <TD WIDTH="33%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2">(Agent for Service of Process)
</FONT></TD>
     <TD WIDTH="33%"><FONT FACE="Times New Roman, Times, Serif" SIZE="2"></FONT></TD></TR>
</TABLE>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>CALCULATION OF
REGISTRATION FEE </FONT></H1>

<BR>
<TABLE WIDTH="100%" BORDER="0" CELLPADDING="0" CELLSPACING="0">
<TR VALIGN="BOTTOM">
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Title of<BR>
Securities<BR>
To Be Registered</FONT><HR WIDTH=90% SIZE=1 COLOR=BLACK NOSHADE></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Amount<BR>
To Be<BR>
Registered</FONT><HR WIDTH=90% SIZE=1 COLOR=BLACK NOSHADE></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Proposed<BR>Maximum<BR>Offering<BR>
Price<BR>
Per Share(1)</FONT><HR WIDTH=90% SIZE=1 COLOR=BLACK NOSHADE></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Proposed<BR>
Maximum<BR>
Aggregate<BR>
Offering<BR>
Price(1)</FONT><HR WIDTH=90% SIZE=1 COLOR=BLACK NOSHADE></TH>
     <TH><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Proposed<BR>
Amount of<BR>
Registration<BR>
Fee(2)</FONT><HR WIDTH=90% SIZE=1 COLOR=BLACK NOSHADE></TH></TR>
<TR VALIGN="TOP">
     <TD WIDTH="20%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2">Common Stock,<BR>
No par value
</FONT></TD>
     <TD WIDTH="20%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2">50,000 Shares
</FONT></TD>
     <TD WIDTH="20%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2">$8.23
</FONT></TD>
     <TD WIDTH="20%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2">$411,500.00
</FONT></TD>
     <TD WIDTH="20%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2">$52.14
</FONT></TD></TR>
</TABLE>
<BR>

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          <TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(1)</FONT></TD>
          <TD WIDTH=95%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
          Estimated to calculate registration fee. </FONT></TD>
          </TR>
          </TABLE>
          <BR>

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          <TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>(2)</FONT></TD>
          <TD WIDTH=95%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
          Calculated pursuant to Rule 457(h) based on the average of the high and low
          prices of the Common Stock on the Nasdaq National Market on November 26, 2004 of
          $8.23 per share. </FONT></TD>
          </TR>
          </TABLE>
          <BR>


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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>REGISTRATION OF
ADDITIONAL SECURITIES<BR>PURSUANT TO GENERAL
INSTRUCTION E </FONT></H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;On
August 22, 2003 Kendle International Inc. filed a Registration Statement on Form S-8 (File
No. 333-108163) for up to 25,000 shares of Common Stock issuable pursuant to the Kendle
International Inc. 2003 Directors&#146; Compensation Plan. At an Annual Meeting of
Shareholders held May 6, 2004 the Shareholders of Kendle International Inc. approved an
increase of 50,000 shares available for issuance pursuant to the Plan. This Registration
Statement is being filed to register the additional 50,000 shares now available for
issuance pursuant to the Plan. Pursuant to General Instruction E of Form S-8, the contents
of the initial Registration Statement are hereby incorporated by reference. </FONT></P>

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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>PART II </FONT></H1>

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<H1 ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Item 8.&nbsp;&nbsp;&nbsp;&nbsp; Exhibits </FONT></H1>

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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=15%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>  Exhibit 5</FONT></TD>
<TD WIDTH=80%><FONT FACE="Times New Roman, Times, Serif" SIZE=2> Opinion of Keating, Muething &amp; Klekamp, P.L.L.</FONT></TD>
</TR>
</TABLE>
<BR>

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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=15%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>  Exhibit 23.1 </FONT></TD>
<TD WIDTH=80%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
              Consent of Deloitte &amp; Touche LLP</FONT></TD>
</TR>
</TABLE>
<BR>

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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=15%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>  Exhibit 23.2</FONT></TD>
<TD WIDTH=80%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
              Consent of PricewaterhouseCoopers LLP</FONT></TD>
</TR>
</TABLE>
<BR>

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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=15%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>  Exhibit 23.3</FONT></TD>
<TD WIDTH=80%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
              Consent of Keating, Muething &amp; Klekamp, P.L.L. (included in Exhibit 5)</FONT></TD>
</TR>
</TABLE>
<BR>

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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;</FONT></TD>
<TD WIDTH=15%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Exhibit 24</FONT></TD>
<TD WIDTH=80%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>
Power of Attorney (contained in the signature page) </FONT></TD>
</TR>
</TABLE>
<BR>



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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>* All Exhibits filed herewith unless
otherwise indicated  </FONT></P>


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<H1 ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>SIGNATURES </FONT></H1>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, the registrant certifies that it has
reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
and has duly caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in Cincinnati, Ohio, on November 22, 2004. </FONT></P>

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<TD WIDTH=40%><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
<TD WIDTH=10%><FONT FACE="Times New Roman, Times, Serif" SIZE=2></FONT></TD>
<TD WIDTH=50%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><B>KENDLE INTERNATIONAL INC.</B><BR><BR>
<BR>BY: /s/ Candace Kendle<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Candace Kendle<BR>Chairman of the Board and<BR>Chief Executive Officer</FONT></TD>
</TR>
</TABLE>
<BR>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, this Registration Statement has been
signed by the following persons in the capacities and on the dates indicated. Persons
whose names are marked with an asterisk (*) below hereby designate Candace Kendle or Karl
Brenkert III as their attorney-in-fact to sign all amendments, including any
post-effective amendments, to this Registration Statement. </FONT></P>
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     <TD WIDTH="40%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U>Signature</U></FONT></TD>
     <TD WIDTH="35%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U>Capacity</U></FONT></TD>
     <TD WIDTH="25%" ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE="2"><U>Date</U></FONT></TD></TR>
</TABLE>

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<TR VALIGN=TOP>
<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=35% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>* /s/ Candace Kendle
<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Candace Kendle</FONT></TD>
<TD WIDTH=35%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Chairman of the Board and Chief
Executive Officer (Principal Executive Officer)</FONT></TD>
<TD WIDTH=25% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>November 22, 2004</FONT></TD>
</TR>
</TABLE>
<BR>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=35% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>* /s/ Christopher C. Bergen
<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Christopher C. Bergen</FONT></TD>
<TD WIDTH=35%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><BR>
President,  Chief  Operating  Officer and Director</FONT></TD>
<TD WIDTH=25% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>November 22, 2004</FONT></TD>
</TR>
</TABLE>
<BR>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=35% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>*
<BR>/s/Karl Brenkert III<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Karl Brenkert III</FONT></TD>
<TD WIDTH=35%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><BR>
Senior Vice President, Chief Financial Officer and<BR>
Treasurer (principal financial officer and<BR>
 principal accounting officer)</FONT></TD>
<TD WIDTH=25% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>November 23, 2004</FONT></TD>
</TR>
</TABLE>
<BR>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=35% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>* /s/ Robert R. Buck
<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Robert R. Buck</FONT></TD>
<TD WIDTH=35%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH=25% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>November 23, 2004</FONT></TD>
</TR>
</TABLE>
<BR>

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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=35% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>*
<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
G. Steven Geis, Ph.D., M.D.</FONT></TD>
<TD WIDTH=35%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH=25% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>November __, 2004</FONT></TD>
</TR>
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<BR>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=35% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>* /s/ Donald C. Harrison
<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Donald C. Harrison, M.D.</FONT></TD>
<TD WIDTH=35%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH=25% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>November 23, 2004</FONT></TD>
</TR>
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<BR>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=35% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>* /s/ Timothy E. Johnson
<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Timothy E. Johnson, Ph.D.</FONT></TD>
<TD WIDTH=35%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH=25% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>November 26, 2004</FONT></TD>
</TR>
</TABLE>
<BR>

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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=35% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>*
<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Frederick A. Russ, Ph.D.</FONT></TD>
<TD WIDTH=35%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH=25% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>November __, 2004</FONT></TD>
</TR>
</TABLE>
<BR>
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<TD WIDTH=5%><FONT FACE="Times New Roman, Times, Serif" SIZE=2>&nbsp; </FONT></TD>
<TD WIDTH=35% ALIGN=LEFT><FONT FACE="Times New Roman, Times, Serif" SIZE=2>*
<BR>&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;&#151;<BR>
Robert C. Simpson</FONT></TD>
<TD WIDTH=35%><FONT FACE="Times New Roman, Times, Serif" SIZE=2><BR>
Director</FONT></TD>
<TD WIDTH=25% ALIGN=CENTER><FONT FACE="Times New Roman, Times, Serif" SIZE=2>November __, 2004</FONT></TD>
</TR>
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<BR>

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Form S-8
As filed with the
Securities and Exchange Commission on December 1, 2004
Registration No. 333-
SECURITIES AND
EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Incorporated
Under the Laws
of Ohio
KENDLE INTERNATIONAL INC.
441 VINE STREET, SUITE 700
CINCINNATI, OHIO 45202
(513) 771-8221
I.R.S. Employer
Identification No.
31-1274091
2003 DIRECTORS'
COMPENSATION PLAN
Gary P. Kreider, Esq.
Keating, Muething & Klekamp, P.L.L.
One East Fourth Street
Cincinnati, Ohio 45202
Phone: (513) 579-6411
Facsimile (513) 579-6956
(Agent for Service of Process)
CALCULATION OF
REGISTRATION FEE
Title of
Securities
To Be Registered
Amount
To Be
Registered
Proposed
Maximum
Offering
Price
Per Share(1)
Proposed
Maximum
Aggregate
Offering
Price(1)
Proposed
Amount of
Registration
Fee(2)
Common Stock,
No par value
50,000 Shares
$8.23
$411,500.00
$52.14
(1)
Estimated to calculate registration fee.
(2)
Calculated pursuant to Rule 457(h) based on the average of the high and low
          prices of the Common Stock on the Nasdaq National Market on November 26, 2004 of
          $8.23 per share.
REGISTRATION OF
ADDITIONAL SECURITIES
PURSUANT TO GENERAL
INSTRUCTION E
On
August 22, 2003 Kendle International Inc. filed a Registration Statement on Form S-8 (File
No. 333-108163) for up to 25,000 shares of Common Stock issuable pursuant to the Kendle
International Inc. 2003 Directors' Compensation Plan. At an Annual Meeting of
Shareholders held May 6, 2004 the Shareholders of Kendle International Inc. approved an
increase of 50,000 shares available for issuance pursuant to the Plan. This Registration
Statement is being filed to register the additional 50,000 shares now available for
issuance pursuant to the Plan. Pursuant to General Instruction E of Form S-8, the contents
of the initial Registration Statement are hereby incorporated by reference.
PART II
Item 8.     Exhibits
Exhibit 5
Opinion of Keating, Muething & Klekamp, P.L.L.
Exhibit 23.1
Consent of Deloitte & Touche LLP
Exhibit 23.2
Consent of PricewaterhouseCoopers LLP
Exhibit 23.3
Consent of Keating, Muething & Klekamp, P.L.L. (included in Exhibit 5)
Exhibit 24
Power of Attorney (contained in the signature page)
* All Exhibits filed herewith unless
otherwise indicated
SIGNATURES
Pursuant
to the requirements of the Securities Act of 1933, the registrant certifies that it has
reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
and has duly caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in Cincinnati, Ohio, on November 22, 2004.
KENDLE INTERNATIONAL INC.
BY: /s/ Candace Kendle
——————————————
Candace Kendle
Chairman of the Board and
Chief Executive Officer
Pursuant
to the requirements of the Securities Act of 1933, this Registration Statement has been
signed by the following persons in the capacities and on the dates indicated. Persons
whose names are marked with an asterisk (*) below hereby designate Candace Kendle or Karl
Brenkert III as their attorney-in-fact to sign all amendments, including any
post-effective amendments, to this Registration Statement.
Signature
Capacity
Date
* /s/ Candace Kendle
————————————————
Candace Kendle
Chairman of the Board and Chief
Executive Officer (Principal Executive Officer)
November 22, 2004
* /s/ Christopher C. Bergen
————————————————
Christopher C. Bergen
President,  Chief  Operating  Officer and Director
November 22, 2004
*
/s/Karl Brenkert III
————————————————
Karl Brenkert III
Senior Vice President, Chief Financial Officer and
Treasurer (principal financial officer and
principal accounting officer)
November 23, 2004
* /s/ Robert R. Buck
————————————————
Robert R. Buck
Director
November 23, 2004
*
————————————————
G. Steven Geis, Ph.D., M.D.
Director
November __, 2004
* /s/ Donald C. Harrison
————————————————
Donald C. Harrison, M.D.
Director
November 23, 2004
* /s/ Timothy E. Johnson
————————————————
Timothy E. Johnson, Ph.D.
Director
November 26, 2004
*
————————————————
Frederick A. Russ, Ph.D.
Director
November __, 2004
*
————————————————
Robert C. Simpson
Director
November __, 2004