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<P STYLE="font: 9pt Times New Roman,serif; margin: 0; text-align: center">As filed with the Securities and Exchange Commission
on August 8, 2012</P>

<P STYLE="font: 9pt Times New Roman,serif; margin: 0; text-align: right">&nbsp;</P>

<P STYLE="font: 9pt Times New Roman,serif; margin: 0; text-align: right; border-bottom: Black 2.5pt double">Registration No. 333-_______<br>&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 12pt 0 0; text-align: center">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</P>

<P STYLE="font: 9pt Times New Roman,serif; margin: 0; text-align: center">Washington, D.C. 20549</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 6pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-size: 12pt">FORM&nbsp;S-8<BR>
</FONT>REGISTRATION STATEMENT UNDER THE<BR>
SECURITIES ACT OF 1933</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-size: 12pt">ST. JUDE MEDICAL,
INC.<BR>
</FONT><FONT STYLE="font-size: 9pt; font-weight: normal">(Exact name of registrant as specified in its charter)</FONT></P>

<TABLE ALIGN="CENTER" CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 36%; font: 10pt Times New Roman,serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Minnesota<BR>
</B></FONT>(State or other jurisdiction<BR>
of incorporation or organization)</TD>
    <TD STYLE="width: 2%; font: 9pt Times New Roman,serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 26%; font: 9pt Times New Roman,serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 2%; font: 9pt Times New Roman,serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 34%; font: 10pt Times New Roman,serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>41-1276891<BR>
</B></FONT>(I.R.S. Employer<BR>
Identification No.)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 2pt 0 4pt; text-align: center"><B>One St. Jude Medical Drive<BR>
St. Paul, Minnesota 55117<BR>
</B><FONT STYLE="font-size: 9pt">(Address of principal executive offices,<BR>
including zip code)</FONT></P>

<P STYLE="font: 9pt Times New Roman,serif; margin: 0 0 4pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman Bold,serif; margin: 0; text-align: center"><FONT STYLE="text-transform: uppercase">St.
Jude Medical, Inc. 2007 Employee stock purchase plan, </FONT></P>

<P STYLE="font: bold 10pt Times New Roman Bold,serif; margin: 0; text-align: center"><FONT STYLE="text-transform: uppercase">as
amended effective august 1, 2012</FONT></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 4pt; text-align: center"><FONT STYLE="font-size: 9pt">(Full title of the
plan)<BR STYLE="mso-special-character: line-break">
<BR STYLE="mso-special-character: line-break">
</FONT></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 6pt; text-align: center"><B>Jason A. Zellers<BR>
Vice President, General Counsel and Corporate Secretary<BR>
St. Jude Medical, Inc.<BR>
One St. Jude Medical Drive<BR>
St. Paul, Minnesota 55117<BR>
(651) 756-2000<BR>
</B><FONT STYLE="font-size: 9pt">(Name, address and telephone number,<BR>
including area code, of agent for service)<BR STYLE="mso-special-character: line-break">
<BR STYLE="mso-special-character: line-break">
</FONT></P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; background-color: white">Indicate by check mark whether the registrant is
a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of
&ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule&nbsp;12b-2
of the Exchange Act.</P>

<P STYLE="font: 1pt Times New Roman,serif; margin: 0">&nbsp;</P>

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<TR>
    <TD STYLE="width: 39%; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 14%; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 47%; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD NOWRAP STYLE="font-family: Times New Roman,serif"><FONT STYLE="color: black">Large accelerated filer&nbsp;</FONT><FONT STYLE="font-family: Wingdings 2">&#83;</FONT></TD>
    <TD NOWRAP STYLE="font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD NOWRAP STYLE="font-family: Times New Roman,serif"><FONT STYLE="color: black">Accelerated filer&nbsp;<FONT STYLE="font-family: Wingdings 2">&#163;</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD NOWRAP STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD NOWRAP STYLE="font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD NOWRAP STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD NOWRAP STYLE="font-family: Times New Roman,serif"><FONT STYLE="color: black">Non-accelerated filer&nbsp;<FONT STYLE="font-family: Wingdings 2">&#163;</FONT></FONT></TD>
    <TD NOWRAP STYLE="font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD NOWRAP STYLE="font-family: Times New Roman,serif"><FONT STYLE="color: black">Smaller reporting company&nbsp;<FONT STYLE="font-family: Wingdings 2">&#163;</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD NOWRAP STYLE="font-family: Times New Roman,serif">(Do not check if a smaller reporting company)</TD>
    <TD NOWRAP STYLE="font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD NOWRAP STYLE="font-family: Times New Roman,serif; text-align: right">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 1pt Times New Roman,serif; margin: 0">&nbsp;</P>

<P STYLE="font: 9pt Times New Roman,serif; margin: 0 0 6pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 6pt; text-align: center">CALCULATION OF REGISTRATION FEE</P>

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<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 32%; border: black 1pt solid; font: bold 9pt Times New Roman,serif; padding-right: 4.95pt; padding-left: 4.95pt; text-align: center; vertical-align: bottom"><B>Title
    of securities to be registered</B></TD>
    <TD STYLE="width: 16%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: bold 9pt Times New Roman,serif; border-left-color: black; border-left-width: 1pt; padding-right: 4.95pt; padding-left: 4.95pt; text-align: center; vertical-align: bottom"><B>Amount
    <BR> to be<BR>
 registered(1)(2)</B></TD>
    <TD STYLE="width: 17%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 9pt Times New Roman,serif; border-left-color: black; border-left-width: 1pt; padding-right: 4.95pt; padding-left: 4.95pt; text-align: center; vertical-align: bottom"><B>Proposed<BR>

    maximum<BR> offering price <BR>
per share(3)</B></TD>
    <TD STYLE="width: 20%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 9pt Times New Roman,serif; border-left-color: black; border-left-width: 1pt; padding-right: 4.95pt; padding-left: 4.95pt; text-align: center; vertical-align: bottom"><B>Proposed
    maximum<BR> aggregate offering<BR>
 price(3)</B></TD>
    <TD STYLE="width: 15%; border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; font: 9pt Times New Roman,serif; border-left-color: black; border-left-width: 1pt; padding-right: 4.95pt; padding-left: 4.95pt; text-align: center; vertical-align: bottom"><B>Amount
    of <BR> registration fee</B></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; border-top-color: black; font: 9pt Times New Roman,serif; border-top-width: 1pt; padding-right: 4.95pt; padding-left: 4.95pt">Common Stock, <BR> par value $0.10 per share</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 9pt Times New Roman,serif; padding-right: 4.95pt; padding-left: 4.95pt; text-align: center">6,000,000 Shares</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 9pt Times New Roman,serif; padding-right: 4.95pt; padding-left: 4.95pt; text-align: center">$36.83</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 9pt Times New Roman,serif; padding-right: 4.95pt; padding-left: 4.95pt; text-align: center">$220,980,000</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; font: 9pt Times New Roman,serif; padding-right: 4.95pt; padding-left: 4.95pt; text-align: center">$25,325</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 9pt Times New Roman,serif; margin-top: 3pt; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>Represents the shares of common stock of St. Jude Medical, Inc. that may be offered or sold pursuant to the St. Jude Medical,
Inc. 2007 Employee Stock Purchase Plan, as amended effective August 1, 2012.</TD></TR></TABLE>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(2)</TD><TD>Pursuant to Rule 416 under the Securities Act of 1933, as amended, this registration statement also covers any additional shares
of common stock that may be offered or issued under the St. Jude Medical, Inc. 2007 Employee Stock Purchase Plan, as amended effective
August 1, 2012, to prevent dilution resulting from stock splits, stock dividends or similar transactions.</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 9pt Times New Roman,serif; margin-top: 3pt; margin-bottom: 12pt; border-bottom: Black 2.5pt double"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(3)</TD><TD>Estimated solely for the purpose of calculating the registration fee in accordance with Rule 457(h)(1) and (c) under the Securities
Act of 1933, as amended. The proposed maximum offering price is based on the average of the high and low prices of St. Jude Medical,
Inc. common stock as reported on the New York Stock Exchange on August 2, 2012.<BR>&nbsp;</TD></TR></TABLE>


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<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 28pt; text-transform: uppercase; text-align: center">PART II<BR>
&nbsp;<BR>
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt">Item 3.&#9;Incorporation of Documents by Reference.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">The following documents, which have been filed
with the Securities and Exchange Commission (the &ldquo;SEC&rdquo;) by St. Jude Medical, Inc.<FONT STYLE="font-size: 9pt"> </FONT>(&ldquo;we,&rdquo;
&ldquo;us,&rdquo; &ldquo;our&rdquo; or &ldquo;St. Jude&rdquo;), are incorporated by reference in this registration statement:</P>

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<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(a)</TD><TD>Our Annual Report on Form 10-K for the fiscal year ended December 31, 2011;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman,serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(b)</TD><TD>Our Quarterly Reports on Form 10-Q for the fiscal quarters ended March 31, 2012 and June&nbsp;30,&nbsp;2012;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman,serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(c)</TD><TD>Our Current Report on Form 8-K filed on May 4, 2012; and</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman,serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(d)</TD><TD>The description of our common stock contained in any registration statement or report filed by us under the Securities Exchange
Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;), including any amendment or report filed for the purpose of updating such
description.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">All documents filed by us pursuant to Sections&nbsp;13(a),
13(c), 14 and 15(d) of the Exchange Act subsequent to the date hereof, and prior to the filing of a post-effective amendment which
indicates that all securities offered hereby have been sold or which deregisters all securities remaining unsold, shall be deemed
to be incorporated by reference herein and to be a part hereof from the respective dates of filing of such documents.</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt">Item 4.&#9;Description of Securities.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt">Item 5.&#9;Interests of Named Experts and Counsel.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt">Item 6.&#9;Indemnification of Directors and Officers.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">Section&nbsp;521 of the Minnesota Business Corporation
Act provides that a company shall, subject to certain limitations, indemnify officers and directors made or threatened to be made
a party to a proceeding by reason of that officer or director&rsquo;s former or present official capacity with the company. As
required, we will indemnify that person against judgments, penalties, fines, settlements and reasonable expenses if the officer
or director:</P>

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<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>has not been indemnified by another organization;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman,serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>acted in good faith;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman,serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>has not received an improper personal benefit and Section 255 regarding director conflicts of interests, if applicable, has
been satisfied;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman,serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>assuming the case is a criminal proceeding, the person had no reasonable cause to believe the conduct was unlawful; and</TD></TR></TABLE>
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<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>reasonably believed that the conduct was in the best interests of the company or, in the case of an officer or director who
is or was serving at the request of the company as a director, officer, partner, trustee, employee or agent of another organization
or employee benefit plan, reasonably believed that the conduct was not opposed to the best interests of the company.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">Article XIV of our Articles of Incorporation,
as amended, provides that, to the fullest extent permissible under the Minnesota Business Corporation Act, our directors shall
not be liable to St. Jude or our shareholders for monetary damages for breach of fiduciary duty as a director.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">Article VII of our Bylaws, as amended and restated,
provides that we shall indemnify our officers and directors under such circumstances and to the extent permitted by Section 521
of the Minnesota Business Corporation Act described above.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">We enter into indemnification agreements with
our directors and officers. The indemnification agreements provide that we shall, subject to certain limitations, indemnify our
directors and officers who are made or threatened to be made a party to a proceeding by reason of their former or present official
capacities with St. Jude. The circumstances under which we will indemnify our directors or officers against judgments, penalties,
fines, settlements and reasonable expenses pursuant to these indemnification agreements are the same as those provided in Section
521 of the Minnesota Business Corporation Act described above.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">We maintain directors&rsquo; and officers&rsquo;
liability insurance which covers certain liabilities and expenses of our directors and officers and covers St. Jude for reimbursement
of payments to our directors and officers in respect of such liabilities and expenses.</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt">Item 7.&#9;Exemption from Registration Claimed.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">Not applicable.</P>

<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt">Item 8.&#9;Exhibits.</P>

<TABLE ALIGN="CENTER" CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 10%; font: 10pt Times New Roman,serif; text-align: center">4.1</TD>
    <TD STYLE="width: 90%">
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Articles of Incorporation, as amended on May 9, 2008 (incorporated by reference
        to Exhibit 3.1 of St. Jude&rsquo;s Quarterly Report on Form 10-Q for the quarter ended June 28, 2008).</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: center">4.2</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Bylaws, as amended and restated as of February 25, 2005 (incorporated by
        reference to Exhibit&nbsp;3.1 of St. Jude&rsquo;s Current Report on Form 8-K filed on March 2, 2005).</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: center">4.3</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Specimen Common Stock Certificate (incorporated by reference to Exhibit
        4.1 of St. Jude&rsquo;s Registration Statement on Form S-4 filed on October 20, 2010 (File No. 333-170045)).</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: center">4.4</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">St. Jude Medical, Inc. 2007 Employee Stock Purchase Plan, as amended effective
        August 1, 2012 (incorporated by reference to Exhibit&nbsp;10.1 of St. Jude&rsquo;s Current Report on Form 8-K filed on May&nbsp;4,&nbsp;2012).</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: center">5.1</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Opinion of Dorsey &amp; Whitney LLP.</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: center">23.1</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Consent of Dorsey &amp; Whitney LLP (included in Exhibit 5.1).</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: center">23.2</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Consent of Ernst &amp; Young LLP.</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: center">24.1</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Power of Attorney.</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt">&nbsp;</P>

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<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt">Item 9.&#9;Undertakings.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">(a)&#9;The undersigned registrant hereby undertakes:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt 0.5in; text-indent: 0.5in">(1)&#9;To file, during any period in which
offers or sales are being made, a post-effective amendment to this registration statement:</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt 1in; text-indent: 0.5in">(i)&#9;To include any prospectus required
by Section&nbsp;10(a)(3) of the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;);</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt 1in; text-indent: 0.5in">(ii)&#9;To reflect in the prospectus any
facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof)
which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities
offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering
range may be reflected in the form of prospectus filed with the SEC pursuant to Rule&nbsp;424(b) if, in the aggregate, the changes
in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the &ldquo;Calculation
of Registration Fee&rdquo; table in the effective registration statement; and</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt 1in; text-indent: 0.5in">(iii)&#9;To include any material information
with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such
information in the registration statement;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt 0.5in"><I>provided</I>, <I>however,</I> that paragraphs&nbsp;(a)(1)(i)
and (a)(1)(ii) above do not apply if the information required to be included in a post-effective amendment by those paragraphs
is contained in reports filed with or furnished to the SEC by the registrant pursuant to Section&nbsp;13 or Section&nbsp;15(d)
of the Exchange Act that are incorporated by reference in the registration statement.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt 0.5in; text-indent: 0.5in">(2)&#9;That, for the purpose of determining
any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt 0.5in; text-indent: 0.5in">(3)&#9;To remove from registration by means
of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">(b)&#9;The undersigned registrant hereby undertakes
that, for purposes of determining any liability under the Securities Act, each filing of the registrant&rsquo;s annual report pursuant
to Section&nbsp;13(a) or Section&nbsp;15(d) of the Exchange Act that is incorporated by reference in the registration statement
shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">(c)&#9;Insofar as indemnification for liabilities
arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to
the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the SEC such indemnification is
against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</P>

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<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 12pt; text-align: center">SIGNATURES</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-indent: 0.5in">Pursuant to the requirements of the Securities Act,
the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form&nbsp;S-8
and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the
City of St.&nbsp;Paul, State of Minnesota, on August 8, 2012.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font-size: 10pt; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">ST. JUDE MEDICAL, INC.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 58%; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 39%; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">By</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif">s/ John C. Heinmiller</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">John C. Heinmiller<BR> Executive Vice President and <BR> Chief Financial Officer</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act, this registration statement has been signed by the following persons in the capacities indicated on August 8, 2012.</P>

<TABLE ALIGN="CENTER" CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif; font-weight: bold">Signature</TD>
    <TD ROWSPAN="3" STYLE="font-family: Times New Roman,serif; font-weight: bold">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif; font-weight: bold">Title</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif; text-align: center">*</TD>
    <TD STYLE="font-family: Times New Roman,serif">President, Chief Executive Officer and Chairman</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">Daniel J. Starks</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">(principal executive officer)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif">/s/ John C. Heinmiller</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Executive Vice President and Chief Financial Officer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">John C. Heinmiller</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">(principal financial and accounting officer)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; vertical-align: bottom; font-family: Times New Roman,serif; text-align: center">*</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">John W. Brown</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; vertical-align: bottom; font-family: Times New Roman,serif; text-align: center">*</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">Richard R. Devenuti</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; vertical-align: bottom; font-family: Times New Roman,serif; text-align: center">*</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">Stuart M. Essig</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; vertical-align: bottom; font-family: Times New Roman,serif; text-align: center">*</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">Thomas H. Garrett III</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; vertical-align: bottom; font-family: Times New Roman,serif; text-align: center">*</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">Barbara B. Hill</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; vertical-align: bottom; font-family: Times New Roman,serif; text-align: center">*</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">Michael A. Rocca</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; vertical-align: bottom; font-family: Times New Roman,serif; text-align: center">*</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-family: Times New Roman,serif">Director</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">Wendy L. Yarno</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; font-family: Times New Roman,serif">*By:</TD>
    <TD STYLE="width: 44%; border-bottom: windowtext 1pt solid; font-family: Times New Roman,serif">/s/ Jason A. Zellers</TD>
    <TD STYLE="width: 4%; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 47%; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Jason A. Zellers<BR> Attorney-in-Fact</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 12pt; text-indent: 0.5in">&nbsp;</P>

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<P STYLE="font: bold 10pt Times New Roman,serif; margin: 0 0 0.25in; text-align: center"><FONT STYLE="text-transform: uppercase">Exhibit
Index</FONT></P>

<TABLE ALIGN="CENTER" CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 14%; border-bottom: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; font-family: Times New Roman,serif; font-weight: bold">Exhibit<BR> Number</TD>
    <TD STYLE="width: 3%; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; font-family: Times New Roman,serif; font-weight: bold">&nbsp;</TD>
    <TD STYLE="width: 83%; border-bottom: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; font-family: Times New Roman,serif; font-weight: bold">Description</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif; text-align: center">4.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Articles of Incorporation, as amended on May 9, 2008 (incorporated by reference
        to Exhibit&nbsp;3.1 of St. Jude&rsquo;s Quarterly Report on Form 10-Q for the quarter ended June 28, 2008).</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif; text-align: center">4.2</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Bylaws, as amended and restated as of February 25, 2005 (incorporated by
        reference to Exhibit&nbsp;3.1 of St. Jude&rsquo;s Current Report on Form 8-K filed on March 2, 2005).</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif; text-align: center">4.3</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Specimen Common Stock Certificate (incorporated by reference to Exhibit
        4.1 of St. Jude&rsquo;s Registration Statement on Form S-4 filed on October 20, 2010 (File No. 333-170045)).</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif; text-align: center">4.4</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">St. Jude Medical, Inc. 2007 Employee Stock Purchase Plan, as amended effective
        August&nbsp;1,&nbsp;2012 (incorporated by reference to Exhibit 10.1 of St. Jude&rsquo;s Current Report on Form 8-K filed on May
        4, 2012).</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif; text-align: center">5.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Opinion of Dorsey &amp; Whitney LLP.</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif; text-align: center">23.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Consent of Dorsey &amp; Whitney LLP (included in Exhibit 5.1).</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif; text-align: center">23.2</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Consent of Ernst &amp; Young LLP.</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif; text-align: center">24.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Power of Attorney.</P>
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[{"type": "S-8", "sequence": "1", "filename": "stjude12345_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 49302}]
{"company-data": {"conformed-name": "ST JUDE MEDICAL INC", "cik": "0000203077", "assigned-sic": "3845", "irs-number": "411276891", "state-of-incorporation": "MN", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-183159", "film-number": "121017229"}, "business-address": {"street1": "ONE ST JUDE MEDICAL DRIVE", "city": "ST PAUL", "state": "MN", "zip": "55117", "phone": "6517562000"}, "mail-address": {"street1": "ONE ST JUDE MEDICAL DRIVE", "city": "ST PAUL", "state": "MN", "zip": "55117"}}
As filed with the Securities and Exchange Commission
on August 8, 2012
Registration No. 333-_______
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE
SECURITIES ACT OF 1933
ST. JUDE MEDICAL,
INC.
(Exact name of registrant as specified in its charter)
Minnesota
(State or other jurisdiction
of incorporation or organization)
41-1276891
(I.R.S. Employer
Identification No.)
One St. Jude Medical Drive
St. Paul, Minnesota 55117
(Address of principal executive offices,
including zip code)
St.
Jude Medical, Inc. 2007 Employee stock purchase plan,
as
amended effective august 1, 2012
(Full title of the
plan)
Jason A. Zellers
Vice President, General Counsel and Corporate Secretary
St. Jude Medical, Inc.
One St. Jude Medical Drive
St. Paul, Minnesota 55117
(651) 756-2000
(Name, address and telephone number,
including area code, of agent for service)
Indicate by check mark whether the registrant is
a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of
"large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2
of the Exchange Act.
Large accelerated filer
S
Accelerated filer
£
Non-accelerated filer
£
Smaller reporting company
£
(Do not check if a smaller reporting company)
CALCULATION OF REGISTRATION FEE
Title
    of securities to be registered
Amount
to be
registered(1)(2)
Proposed
maximum
offering price
per share(3)
Proposed
    maximum
aggregate offering
price(3)
Amount
    of
registration fee
Common Stock,
par value $0.10 per share
6,000,000 Shares
$36.83
$220,980,000
$25,325
(1)
Represents the shares of common stock of St. Jude Medical, Inc. that may be offered or sold pursuant to the St. Jude Medical,
Inc. 2007 Employee Stock Purchase Plan, as amended effective August 1, 2012.
(2)
Pursuant to Rule 416 under the Securities Act of 1933, as amended, this registration statement also covers any additional shares
of common stock that may be offered or issued under the St. Jude Medical, Inc. 2007 Employee Stock Purchase Plan, as amended effective
August 1, 2012, to prevent dilution resulting from stock splits, stock dividends or similar transactions.
(3)
Estimated solely for the purpose of calculating the registration fee in accordance with Rule 457(h)(1) and (c) under the Securities
Act of 1933, as amended. The proposed maximum offering price is based on the average of the high and low prices of St. Jude Medical,
Inc. common stock as reported on the New York Stock Exchange on August 2, 2012.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.	Incorporation of Documents by Reference.
The following documents, which have been filed
with the Securities and Exchange Commission (the "SEC") by St. Jude Medical, Inc.
("we,"
"us," "our" or "St. Jude"), are incorporated by reference in this registration statement:
(a)
Our Annual Report on Form 10-K for the fiscal year ended December 31, 2011;
(b)
Our Quarterly Reports on Form 10-Q for the fiscal quarters ended March 31, 2012 and June 30, 2012;
(c)
Our Current Report on Form 8-K filed on May 4, 2012; and
(d)
The description of our common stock contained in any registration statement or report filed by us under the Securities Exchange
Act of 1934, as amended (the "Exchange Act"), including any amendment or report filed for the purpose of updating such
description.
All documents filed by us pursuant to Sections 13(a),
13(c), 14 and 15(d) of the Exchange Act subsequent to the date hereof, and prior to the filing of a post-effective amendment which
indicates that all securities offered hereby have been sold or which deregisters all securities remaining unsold, shall be deemed
to be incorporated by reference herein and to be a part hereof from the respective dates of filing of such documents.
Item 4.	Description of Securities.
Not applicable.
Item 5.	Interests of Named Experts and Counsel.
Not applicable.
Item 6.	Indemnification of Directors and Officers.
Section 521 of the Minnesota Business Corporation
Act provides that a company shall, subject to certain limitations, indemnify officers and directors made or threatened to be made
a party to a proceeding by reason of that officer or director's former or present official capacity with the company. As
required, we will indemnify that person against judgments, penalties, fines, settlements and reasonable expenses if the officer
or director:
·
has not been indemnified by another organization;
·
acted in good faith;
·
has not received an improper personal benefit and Section 255 regarding director conflicts of interests, if applicable, has
been satisfied;
·
assuming the case is a criminal proceeding, the person had no reasonable cause to believe the conduct was unlawful; and
II-
1
·
reasonably believed that the conduct was in the best interests of the company or, in the case of an officer or director who
is or was serving at the request of the company as a director, officer, partner, trustee, employee or agent of another organization
or employee benefit plan, reasonably believed that the conduct was not opposed to the best interests of the company.
Article XIV of our Articles of Incorporation,
as amended, provides that, to the fullest extent permissible under the Minnesota Business Corporation Act, our directors shall
not be liable to St. Jude or our shareholders for monetary damages for breach of fiduciary duty as a director.
Article VII of our Bylaws, as amended and restated,
provides that we shall indemnify our officers and directors under such circumstances and to the extent permitted by Section 521
of the Minnesota Business Corporation Act described above.
We enter into indemnification agreements with
our directors and officers. The indemnification agreements provide that we shall, subject to certain limitations, indemnify our
directors and officers who are made or threatened to be made a party to a proceeding by reason of their former or present official
capacities with St. Jude. The circumstances under which we will indemnify our directors or officers against judgments, penalties,
fines, settlements and reasonable expenses pursuant to these indemnification agreements are the same as those provided in Section
521 of the Minnesota Business Corporation Act described above.
We maintain directors' and officers'
liability insurance which covers certain liabilities and expenses of our directors and officers and covers St. Jude for reimbursement
of payments to our directors and officers in respect of such liabilities and expenses.
Item 7.	Exemption from Registration Claimed.
Not applicable.
Item 8.	Exhibits.
4.1
Articles of Incorporation, as amended on May 9, 2008 (incorporated by reference
        to Exhibit 3.1 of St. Jude's Quarterly Report on Form 10-Q for the quarter ended June 28, 2008).
4.2
Bylaws, as amended and restated as of February 25, 2005 (incorporated by
        reference to Exhibit 3.1 of St. Jude's Current Report on Form 8-K filed on March 2, 2005).
4.3
Specimen Common Stock Certificate (incorporated by reference to Exhibit
        4.1 of St. Jude's Registration Statement on Form S-4 filed on October 20, 2010 (File No. 333-170045)).
4.4
St. Jude Medical, Inc. 2007 Employee Stock Purchase Plan, as amended effective
        August 1, 2012 (incorporated by reference to Exhibit 10.1 of St. Jude's Current Report on Form 8-K filed on May 4, 2012).
5.1
Opinion of Dorsey & Whitney LLP.
23.1
Consent of Dorsey & Whitney LLP (included in Exhibit 5.1).
23.2
Consent of Ernst & Young LLP.
24.1
Power of Attorney.
II-
2
Item 9.	Undertakings.
(a)	The undersigned registrant hereby undertakes:
(1)	To file, during any period in which
offers or sales are being made, a post-effective amendment to this registration statement:
(i)	To include any prospectus required
by Section 10(a)(3) of the Securities Act of 1933, as amended (the "Securities Act");
(ii)	To reflect in the prospectus any
facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof)
which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities
offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering
range may be reflected in the form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes
in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation
of Registration Fee" table in the effective registration statement; and
(iii)	To include any material information
with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such
information in the registration statement;
provided
,
however,
that paragraphs (a)(1)(i)
and (a)(1)(ii) above do not apply if the information required to be included in a post-effective amendment by those paragraphs
is contained in reports filed with or furnished to the SEC by the registrant pursuant to Section 13 or Section 15(d)
of the Exchange Act that are incorporated by reference in the registration statement.
(2)	That, for the purpose of determining
any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof.
(3)	To remove from registration by means
of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)	The undersigned registrant hereby undertakes
that, for purposes of determining any liability under the Securities Act, each filing of the registrant's annual report pursuant
to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated by reference in the registration statement
shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.
(c)	Insofar as indemnification for liabilities
arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to
the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the SEC such indemnification is
against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
II-
3
SIGNATURES
Pursuant to the requirements of the Securities Act,
the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the
City of St. Paul, State of Minnesota, on August 8, 2012.
ST. JUDE MEDICAL, INC.
By
s/ John C. Heinmiller
John C. Heinmiller
Executive Vice President and
Chief Financial Officer
Pursuant to the requirements of the Securities
Act, this registration statement has been signed by the following persons in the capacities indicated on August 8, 2012.
Signature
Title
*
President, Chief Executive Officer and Chairman
Daniel J. Starks
(principal executive officer)
/s/ John C. Heinmiller
Executive Vice President and Chief Financial Officer
John C. Heinmiller
(principal financial and accounting officer)
*
Director
John W. Brown
*
Director
Richard R. Devenuti
*
Director
Stuart M. Essig
*
Director
Thomas H. Garrett III
*
Director
Barbara B. Hill
*
Director
Michael A. Rocca
*
Director
Wendy L. Yarno
*By:
/s/ Jason A. Zellers
Jason A. Zellers
Attorney-in-Fact
II-
4
Exhibit
Index
Exhibit
Number
Description
4.1
Articles of Incorporation, as amended on May 9, 2008 (incorporated by reference
        to Exhibit 3.1 of St. Jude's Quarterly Report on Form 10-Q for the quarter ended June 28, 2008).
4.2
Bylaws, as amended and restated as of February 25, 2005 (incorporated by
        reference to Exhibit 3.1 of St. Jude's Current Report on Form 8-K filed on March 2, 2005).
4.3
Specimen Common Stock Certificate (incorporated by reference to Exhibit
        4.1 of St. Jude's Registration Statement on Form S-4 filed on October 20, 2010 (File No. 333-170045)).
4.4
St. Jude Medical, Inc. 2007 Employee Stock Purchase Plan, as amended effective
        August 1, 2012 (incorporated by reference to Exhibit 10.1 of St. Jude's Current Report on Form 8-K filed on May
        4, 2012).
5.1
Opinion of Dorsey & Whitney LLP.
23.1
Consent of Dorsey & Whitney LLP (included in Exhibit 5.1).
23.2
Consent of Ernst & Young LLP.
24.1
Power of Attorney.