REGISTRATION NO. 333-
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     ------
                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                                     ------

                           ORASURE TECHNOLOGIES, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

                Delaware                              36-4370966
        (STATE OF INCORPORATION)           (IRS EMPLOYER IDENTIFICATION NO.)

           8505 S.W. Creekside Place

           Beaverton, Oregon                             97008
(ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)              (ZIP CODE)


                ORASURE TECHNOLOGIES, INC. 2000 STOCK AWARD PLAN

                ORASURE TECHNOLOGIES, INC. EMPLOYEE INCENTIVE AND
                         NON-QUALIFIED STOCK OPTION PLAN
                            (FULL TITLE OF THE PLAN)

                               Robert D. Thompson
                             Chief Executive Officer
                           OraSure Technologies, Inc.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008
                            Telephone (503) 641-6115
           (NAME, ADDRESS, AND TELEPHONE NUMBER OF AGENT FOR SERVICE)

<TABLE>
                                           CALCULATION OF REGISTRATION FEE
===================================================================================================================
                                                        PROPOSED MAXIMUM      PROPOSED MAXIMUM
              TITLE OF                  AMOUNT TO BE      OFFERING PRICE          AGGREGATE          AMOUNT OF
    SECURITIES TO BE REGISTERED          REGISTERED          PER SHARE          OFFERING PRICE    REGISTRATION FEE
-------------------------------------------------------------------------------------------------------------------
<S>                      <C>          <C>                       <C>              <C>                 <C>
 Common Stock, par value $.000001     6,185,400 shares          (1)              $33,134,434(1)      $8,748.00
 per share and options and other
 rights related thereto
===================================================================================================================

(1)  Pursuant to Rule 457(h),  the proposed  maximum  aggregate  offering price and the  registration  fee have been
     computed based on the exercise price for 3,337,158  options to purchase  shares of OraSure  Technologies,  Inc.
     common stock,  par value $.000001 per share ("Common  Stock"),  granted prior to the date of this  Registration
     Statement  and on the basis of the average of the high and low sales  prices,  $7.063 reported for the Common
     Stock on the Nasdaq  National Market on November 17, 2000, for the remaining  2,848,242  shares of Common Stock
     currently being registered.
===================================================================================================================
</TABLE>

<PAGE>

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.
         ---------------------------------------

         The following documents filed by the registrant with the Securities and
Exchange   Commission  are  incorporated  by  reference  in  this   registration
statement:

         (a)  OraSure's  Quarterly  Report on Form 10-Q for the  fiscal  quarter
ended September 30, 2000 (the "September 30 10-Q");

         (b)  OraSure's Transition Report on Form 10-Q for the transition period
from  October 1, 1999,  to  December  31,  1999,  relating  to the change in the
registrant's fiscal year-end from September 30 to December 31;

         (c)  OraSure's  Current Report on Form 8-K dated September 29, 2000, as
filed by the registrant on October 16, 2000; and

         (d)  The  description  of the  registrant's  capital stock  included as
Exhibit 99 to the September 30 10-Q.

         In addition,  the registrant is the successor to Epitope,  Inc.,  under
Rule 12g-3(a) of the Securities  Exchange Act of 1934, as amended (the "Exchange
Act").  Epitope was  previously  subject to the  reporting  requirements  of the
Exchange Act. The following  documents as filed by Epitope are also incorporated
by reference:

         (a)  Epitope's  Annual  Report on Form 10-K for the  fiscal  year ended
September 30, 1999;

         (b)  Epitope's  Quarterly  Reports on Form 10-Q for the fiscal quarters
ended December 31, 1999, March 31, 2000, and June 30, 2000; and

         (c)  Epitope's  Current  Reports on Form 8-K dated October 1, 1999, May
6, 2000, and September 29, 2000.

         In addition,  all documents  filed by the registrant  subsequent to the
date of filing of this Registration Statement pursuant to Sections 13(a), 13(c),
14 or  15(d)  of the  Exchange  Act  prior  to the  filing  of a  post-effective
amendment  which  indicates that all securities  offered have been sold or which
deregisters  all  securities  then  remaining  unsold,  shall  be  deemed  to be
incorporated  by reference  into this  registration  statement  and to be a part
hereof from the date of filing of such documents.

Item 4.  Description of Securities.
         -------------------------

                  Not applicable.

Item 5.  Interests of Named Experts and Counsel.
         --------------------------------------

                  None.

Item 6.  Indemnification of Directors and Officers.
         -----------------------------------------

         Delaware  law  authorizes  a  corporation  to  limit or  eliminate  the
personal  liability  of its  directors  for  monetary  damages  for  breach of a
director's fiduciary duty of care. Delaware law further enables
<PAGE>

corporations to limit available relief to equitable  remedies such as injunction
or rescission.  Absent the limitations authorized by Delaware law, directors are
accountable for monetary  damages for conduct  constituting  gross negligence in
the  exercise  of  their  duty  of  care.   The   registrant's   Certificate  of
Incorporation  limits the  liability  of its  directors  to the  fullest  extent
permitted by Delaware law. Accordingly,  the registrant's  directors will not be
personally liable to the registrant or its stockholders for monetary damages for
breach of a fiduciary duty as a director, except for liability for breach of the
duty of  loyalty,  for  acts or  omissions  not in good  faith  or that  involve
intentional  misconduct or a knowing  violation of law, for unlawful payments of
dividends or unlawful  stock  repurchases  or redemptions as provided in Section
174  of the  General  Corporation  Law  of the  State  of  Delaware  or for  any
transaction in which a director has derived an improper personal benefit.

         The  registrant's  bylaws require it to indemnify to the fullest extent
permitted by Delaware law any person who is a party or is  threatened to be made
a party to any action, suit or proceeding by reason of the fact that such person
is or was a  director,  officer,  employee  or  agent of the  registrant,  or is
serving as a director,  officer,  employee or agent of another enterprise at the
registrant's  request.  Indemnification  is not,  however,  permitted  under the
bylaws  unless  the  person  acted in good  faith  and in a manner  such  person
reasonably  believed to be in or not opposed to the registrant's  best interests
and, with respect to any criminal action or proceeding,  that such person had no
reasonable  cause to believe  such  person's  conduct was  unlawful.  The bylaws
further  provide  that the  registrant  shall not  indemnify  any person for any
liabilities  or expenses  incurred by such person in connection  with an action,
suit or proceeding by or in the right of the registrant in respect of any claim,
issue or matter as to which such person shall have been adjudged to be liable to
the  registrant,  unless  and only to the  extent  that the  court in which  the
action,  suit or proceeding is brought determines that the person is entitled to
indemnity for such expenses.  The indemnification  provided by the bylaws is not
exclusive  of any other  rights to which those  seeking  indemnification  may be
otherwise entitled.

         The registrant has entered into indemnification agreements with each of
its directors  and officers.  The  indemnification  agreements  provide that the
registrant will indemnify the directors and officers against all liabilities and
expenses actually and reasonably incurred in connection with any action, suit or
proceeding  (including an action by or in the right of the  registrant) to which
any of them is, was or at any time becomes a party,  or is threatened to be made
a party,  by reason of their status as a director or officer of the  registrant,
or by reason of their  serving or having  served at the  request or on behalf of
the  registrant  as a  director,  officer,  trustee  or in any other  comparable
position  of any other  enterprise  to the  fullest  extent  allowed by law.  No
indemnity will be provided under the indemnification  agreements for any amounts
for which  indemnity  is provided  by any other  indemnification  obligation  or
insurance  maintained  by the  registrant or  otherwise.  Indemnity  will not be
available  to any  director  or officer  on account of conduct  which is finally
adjudged by a court to have been knowingly fraudulent, deliberately dishonest or
willful  misconduct,   if  a  final  court  adjudication  determines  that  such
indemnification  is not lawful,  or in respect of any suit in which  judgment is
rendered  against any director or officer for an accounting of profits made from
a purchase or sale of securities of the registrant in violation of Section 16(b)
of the  Exchange  Act or of any similar  law, or on account of any  remuneration
paid to any  director  or  officer  which is  adjudicated  to have  been paid in
violation of law.

         The  registrant has also obtained  director's  and officer's  liability
insurance.

Item 7.  Exemption from Registration Claimed.
         -----------------------------------

         Not applicable.
<PAGE>

Item 8.  Exhibits.
         --------

         The Index to  Exhibits  listing  the  exhibits  required by Item 601 of
Regulation  S-K  immediately  follows the  signature  page of this  registration
statement.

Item 9.  Undertakings.
         ------------

         (a)  The registrant hereby undertakes:

                   (1)  To file,  during any period in which offers or sales are
              being  made,  a  post-effective  amendment  to  this  registration
              statement:

                           (i)    To include any prospectus  required by Section
              10(a)(3) of the Securities Act of 1933 ("Securities Act");

                           (ii)   To  reflect  in the  prospectus  any  facts or
              events  arising  after  the  effective  date  of the  registration
              statement (or the most recent  post-effective  amendment  thereof)
              which,  individually or in the aggregate,  represent a fundamental
              change in the information set forth in the registration statement;

                           (iii)  To  include  any  material   information  with
              respect to the plan of  distribution  not previously  disclosed in
              the  registration   statement  or  any  material  change  to  such
              information in the registration statement;

PROVIDED,  HOWEVER, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
information  required  to be  included in a  post-effective  amendment  by those
paragraphs is contained in periodic reports filed by the registrant  pursuant to
Section 13 or 15(d) of the Securities Exchange Act of 1934 ("Exchange Act") that
are incorporated by reference in the registration statement.

                   (2)  That, for the purpose of determining any liability under
              the Securities  Act, each such  post-effective  amendment shall be
              deemed  to  be  a  new  registration  statement  relating  to  the
              securities offered therein, and the offering of such securities at
              that time  shall be deemed to be the  initial  bona fide  offering
              thereof.

                   (3)  To remove from registration by means of a post-effective
              amendment  any of the  securities  being  registered  that  remain
              unsold at the termination of the offering.

         (b)  The undersigned registrant hereby undertakes that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  annual  report  pursuant to Section 13(a) or 15(d) of the Exchange
Act (and,  where  applicable,  each filing of an employee  benefit plan's annual
report  pursuant to Section 15(d) of the Exchange Act) that is  incorporated  by
reference in the registration statement shall be deemed to be a new registration
statement relating to the securities  offered therein,  and the offering of such
securities  at that time shall be deemed to be the  initial  bona fide  offering
thereof.

         (h)  Insofar  as  indemnification  for  liabilities  arising  under the
Securities Act may be permitted to directors,  officers and controlling  persons
of the  registrant  pursuant to the  provisions  described  in Item 6 above,  or
otherwise, the registrant has been advised that in the opinion of the Securities
and  Exchange  Commission  such  indemnification  is  against  public  policy as
expressed in the Securities Act and is, therefore,  unenforceable.  In the event
that a claim  for  indemnification  against  such  liabilities  (other  than the
payment by the registrant of expenses incurred or paid by a director, officer or
controlling  person of the registrant in the  successful  defense of any action,
suit or proceeding) is asserted by such director,  officer or controlling person
in connection with the securities being registered,  the registrant will, unless
in the  opinion  of its  counsel  the matter  has been  settled  by  controlling
precedent,  submit to a court of appropriate  jurisdiction  the question whether
such  indemnification  by it is  against  public  policy

<PAGE>
as  expressed  in  the  Securities  Act  and  will  be  governed  by  the  final
adjudication  of such issue.  The undertaking of the registrant in the preceding
sentence  does not  apply to  insurance  against  liability  arising  under  the
Securities Act.
<PAGE>


                                   SIGNATURES

The Registrant.
--------------

         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the  city of  Beaverton,  state  of  Oregon,  on the 17th day of
November, 2000.

                                           OraSure Technologies, Inc.
                                           (Registrant)


                                           By  /s/ Charles E. Bergeron
                                               -------------------------------
                                               Charles E. Bergeron
                                               Chief Financial Officer

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities indicated as of the 17th day of November, 2000.

                     Signature                               Title
                     --------                                -----
   (1)  Principal Executive Officer

   * Robert D. Thompson                     Chief Executive Officer and Director

   (2)  Principal Financial Officer

   /s/ Charles E. Bergeron
   -----------------------------------
   Charles E. Bergeron                      Vice President and
                                            Chief Financial Officer

   (3)  Principal Accounting Officer

   /s/ Theodore R. Gwin
   -----------------------------------
   Theodore R. Gwin                         Controller

   (4)  A majority of the Board of Directors

   * ROGER L. PRINGLE                       Director
   * FRANK G. HAUSMANN, JR.                 Director
   * MICHAEL G. BOLTON                      Director
   * WILLIAM W. CROUSE                      Director
   * MICHAEL J. GAUSLING                    Director

* By  /s/ Charles E. Bergeron
      --------------------------------------
     Charles E. Bergeron
     Attorney-in-fact

<PAGE>


                                INDEX TO EXHIBITS

4.1      Certificate  of  Incorporation  of  the  registrant.   Incorporated  by
         reference to Exhibit 3.1 to the registrant's  Registration Statement on
         Form S-4 (File No. 333-39210) ("Form S-4").

4.1.1    Certificate of Amendment to Certificate of Incorporation  dated May 23,
         2000. Incorporated by reference to Exhibit 3.1.1 to Form S-4.

4.2      Bylaws of the  registrant.  Incorporated by reference to Exhibit 3.2 to
         Form S-4.

4.3      Rights  Agreement  dated as of May 6, 2000,  between the registrant and
         ChaseMellon Shareholder Services,  L.L.C.  Incorporated by reference to
         Exhibit 4.2 to Form S-4.

5        Opinion of Miller Nash LLP.

23.1     Consent of PricewaterhouseCoopers LLP.

23.2     Consent of Arthur Andersen LLP

23.3     Consent of Miller Nash LLP.  Included in Exhibit 5.

24       Power of attorney of certain officers and directors.

---------------

         Other exhibits listed in Item 601 to Regulation S-K are not applicable.
[{"type": "S-8", "sequence": "1", "filename": "0001.txt", "description": "STOCK AWARD PLAN", "secsgml_size_bytes": 18302}]
{"company-data": {"conformed-name": "ORASURE TECHNOLOGIES INC", "cik": "0001116463", "assigned-sic": "3841", "irs-number": "364370966", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-50340", "film-number": "774036"}, "business-address": {"street1": "8505 SW CREEKSIDE PLACE", "city": "BEAVERTON", "state": "OR", "zip": "97008", "phone": "5036416115"}, "mail-address": {"street1": "8505 S W CREEKSIDE PLACE", "city": "BEAVERTON", "state": "OR", "zip": "97008"}}
REGISTRATION NO. 333-
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     ------
                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                                     ------

                           ORASURE TECHNOLOGIES, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

                Delaware                              36-4370966
        (STATE OF INCORPORATION)           (IRS EMPLOYER IDENTIFICATION NO.)

           8505 S.W. Creekside Place

           Beaverton, Oregon                             97008
(ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)              (ZIP CODE)

                ORASURE TECHNOLOGIES, INC. 2000 STOCK AWARD PLAN

                ORASURE TECHNOLOGIES, INC. EMPLOYEE INCENTIVE AND
                         NON-QUALIFIED STOCK OPTION PLAN
                            (FULL TITLE OF THE PLAN)

                               Robert D. Thompson
                             Chief Executive Officer
                           OraSure Technologies, Inc.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008
                            Telephone (503) 641-6115
           (NAME, ADDRESS, AND TELEPHONE NUMBER OF AGENT FOR SERVICE)

                                           CALCULATION OF REGISTRATION FEE
===================================================================================================================
                                                        PROPOSED MAXIMUM      PROPOSED MAXIMUM
              TITLE OF                  AMOUNT TO BE      OFFERING PRICE          AGGREGATE          AMOUNT OF
    SECURITIES TO BE REGISTERED          REGISTERED          PER SHARE          OFFERING PRICE    REGISTRATION FEE
-------------------------------------------------------------------------------------------------------------------
Common Stock, par value $.000001     6,185,400 shares          (1)              $33,134,434(1)      $8,748.00
 per share and options and other
 rights related thereto
===================================================================================================================

(1)  Pursuant to Rule 457(h),  the proposed  maximum  aggregate  offering price and the  registration  fee have been
     computed based on the exercise price for 3,337,158  options to purchase  shares of OraSure  Technologies,  Inc.
     common stock,  par value $.000001 per share ("Common  Stock"),  granted prior to the date of this  Registration
     Statement  and on the basis of the average of the high and low sales  prices,  $7.063 reported for the Common
     Stock on the Nasdaq  National Market on November 17, 2000, for the remaining  2,848,242  shares of Common Stock
     currently being registered.
===================================================================================================================
PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.
         ---------------------------------------

         The following documents filed by the registrant with the Securities and
Exchange   Commission  are  incorporated  by  reference  in  this   registration
statement:

         (a)  OraSure's  Quarterly  Report on Form 10-Q for the  fiscal  quarter
ended September 30, 2000 (the "September 30 10-Q");

         (b)  OraSure's Transition Report on Form 10-Q for the transition period
from  October 1, 1999,  to  December  31,  1999,  relating  to the change in the
registrant's fiscal year-end from September 30 to December 31;

         (c)  OraSure's  Current Report on Form 8-K dated September 29, 2000, as
filed by the registrant on October 16, 2000; and

         (d)  The  description  of the  registrant's  capital stock  included as
Exhibit 99 to the September 30 10-Q.

         In addition,  the registrant is the successor to Epitope,  Inc.,  under
Rule 12g-3(a) of the Securities  Exchange Act of 1934, as amended (the "Exchange
Act").  Epitope was  previously  subject to the  reporting  requirements  of the
Exchange Act. The following  documents as filed by Epitope are also incorporated
by reference:

         (a)  Epitope's  Annual  Report on Form 10-K for the  fiscal  year ended
September 30, 1999;

         (b)  Epitope's  Quarterly  Reports on Form 10-Q for the fiscal quarters
ended December 31, 1999, March 31, 2000, and June 30, 2000; and

         (c)  Epitope's  Current  Reports on Form 8-K dated October 1, 1999, May
6, 2000, and September 29, 2000.

         In addition,  all documents  filed by the registrant  subsequent to the
date of filing of this Registration Statement pursuant to Sections 13(a), 13(c),
14 or  15(d)  of the  Exchange  Act  prior  to the  filing  of a  post-effective
amendment  which  indicates that all securities  offered have been sold or which
deregisters  all  securities  then  remaining  unsold,  shall  be  deemed  to be
incorporated  by reference  into this  registration  statement  and to be a part
hereof from the date of filing of such documents.

Item 4.  Description of Securities.
         -------------------------

                  Not applicable.

Item 5.  Interests of Named Experts and Counsel.
         --------------------------------------

                  None.

Item 6.  Indemnification of Directors and Officers.
         -----------------------------------------

         Delaware  law  authorizes  a  corporation  to  limit or  eliminate  the
personal  liability  of its  directors  for  monetary  damages  for  breach of a
director's fiduciary duty of care. Delaware law further enables
corporations to limit available relief to equitable  remedies such as injunction
or rescission.  Absent the limitations authorized by Delaware law, directors are
accountable for monetary  damages for conduct  constituting  gross negligence in
the  exercise  of  their  duty  of  care.   The   registrant's   Certificate  of
Incorporation  limits the  liability  of its  directors  to the  fullest  extent
permitted by Delaware law. Accordingly,  the registrant's  directors will not be
personally liable to the registrant or its stockholders for monetary damages for
breach of a fiduciary duty as a director, except for liability for breach of the
duty of  loyalty,  for  acts or  omissions  not in good  faith  or that  involve
intentional  misconduct or a knowing  violation of law, for unlawful payments of
dividends or unlawful  stock  repurchases  or redemptions as provided in Section
174  of the  General  Corporation  Law  of the  State  of  Delaware  or for  any
transaction in which a director has derived an improper personal benefit.

         The  registrant's  bylaws require it to indemnify to the fullest extent
permitted by Delaware law any person who is a party or is  threatened to be made
a party to any action, suit or proceeding by reason of the fact that such person
is or was a  director,  officer,  employee  or  agent of the  registrant,  or is
serving as a director,  officer,  employee or agent of another enterprise at the
registrant's  request.  Indemnification  is not,  however,  permitted  under the
bylaws  unless  the  person  acted in good  faith  and in a manner  such  person
reasonably  believed to be in or not opposed to the registrant's  best interests
and, with respect to any criminal action or proceeding,  that such person had no
reasonable  cause to believe  such  person's  conduct was  unlawful.  The bylaws
further  provide  that the  registrant  shall not  indemnify  any person for any
liabilities  or expenses  incurred by such person in connection  with an action,
suit or proceeding by or in the right of the registrant in respect of any claim,
issue or matter as to which such person shall have been adjudged to be liable to
the  registrant,  unless  and only to the  extent  that the  court in which  the
action,  suit or proceeding is brought determines that the person is entitled to
indemnity for such expenses.  The indemnification  provided by the bylaws is not
exclusive  of any other  rights to which those  seeking  indemnification  may be
otherwise entitled.

         The registrant has entered into indemnification agreements with each of
its directors  and officers.  The  indemnification  agreements  provide that the
registrant will indemnify the directors and officers against all liabilities and
expenses actually and reasonably incurred in connection with any action, suit or
proceeding  (including an action by or in the right of the  registrant) to which
any of them is, was or at any time becomes a party,  or is threatened to be made
a party,  by reason of their status as a director or officer of the  registrant,
or by reason of their  serving or having  served at the  request or on behalf of
the  registrant  as a  director,  officer,  trustee  or in any other  comparable
position  of any other  enterprise  to the  fullest  extent  allowed by law.  No
indemnity will be provided under the indemnification  agreements for any amounts
for which  indemnity  is provided  by any other  indemnification  obligation  or
insurance  maintained  by the  registrant or  otherwise.  Indemnity  will not be
available  to any  director  or officer  on account of conduct  which is finally
adjudged by a court to have been knowingly fraudulent, deliberately dishonest or
willful  misconduct,   if  a  final  court  adjudication  determines  that  such
indemnification  is not lawful,  or in respect of any suit in which  judgment is
rendered  against any director or officer for an accounting of profits made from
a purchase or sale of securities of the registrant in violation of Section 16(b)
of the  Exchange  Act or of any similar  law, or on account of any  remuneration
paid to any  director  or  officer  which is  adjudicated  to have  been paid in
violation of law.

         The  registrant has also obtained  director's  and officer's  liability
insurance.

Item 7.  Exemption from Registration Claimed.
         -----------------------------------

         Not applicable.
Item 8.  Exhibits.
         --------

         The Index to  Exhibits  listing  the  exhibits  required by Item 601 of
Regulation  S-K  immediately  follows the  signature  page of this  registration
statement.

Item 9.  Undertakings.
         ------------

         (a)  The registrant hereby undertakes:

                   (1)  To file,  during any period in which offers or sales are
              being  made,  a  post-effective  amendment  to  this  registration
              statement:

                           (i)    To include any prospectus  required by Section
              10(a)(3) of the Securities Act of 1933 ("Securities Act");

                           (ii)   To  reflect  in the  prospectus  any  facts or
              events  arising  after  the  effective  date  of the  registration
              statement (or the most recent  post-effective  amendment  thereof)
              which,  individually or in the aggregate,  represent a fundamental
              change in the information set forth in the registration statement;

                           (iii)  To  include  any  material   information  with
              respect to the plan of  distribution  not previously  disclosed in
              the  registration   statement  or  any  material  change  to  such
              information in the registration statement;

PROVIDED,  HOWEVER, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
information  required  to be  included in a  post-effective  amendment  by those
paragraphs is contained in periodic reports filed by the registrant  pursuant to
Section 13 or 15(d) of the Securities Exchange Act of 1934 ("Exchange Act") that
are incorporated by reference in the registration statement.

                   (2)  That, for the purpose of determining any liability under
              the Securities  Act, each such  post-effective  amendment shall be
              deemed  to  be  a  new  registration  statement  relating  to  the
              securities offered therein, and the offering of such securities at
              that time  shall be deemed to be the  initial  bona fide  offering
              thereof.

                   (3)  To remove from registration by means of a post-effective
              amendment  any of the  securities  being  registered  that  remain
              unsold at the termination of the offering.

         (b)  The undersigned registrant hereby undertakes that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  annual  report  pursuant to Section 13(a) or 15(d) of the Exchange
Act (and,  where  applicable,  each filing of an employee  benefit plan's annual
report  pursuant to Section 15(d) of the Exchange Act) that is  incorporated  by
reference in the registration statement shall be deemed to be a new registration
statement relating to the securities  offered therein,  and the offering of such
securities  at that time shall be deemed to be the  initial  bona fide  offering
thereof.

         (h)  Insofar  as  indemnification  for  liabilities  arising  under the
Securities Act may be permitted to directors,  officers and controlling  persons
of the  registrant  pursuant to the  provisions  described  in Item 6 above,  or
otherwise, the registrant has been advised that in the opinion of the Securities
and  Exchange  Commission  such  indemnification  is  against  public  policy as
expressed in the Securities Act and is, therefore,  unenforceable.  In the event
that a claim  for  indemnification  against  such  liabilities  (other  than the
payment by the registrant of expenses incurred or paid by a director, officer or
controlling  person of the registrant in the  successful  defense of any action,
suit or proceeding) is asserted by such director,  officer or controlling person
in connection with the securities being registered,  the registrant will, unless
in the  opinion  of its  counsel  the matter  has been  settled  by  controlling
precedent,  submit to a court of appropriate  jurisdiction  the question whether
such  indemnification  by it is  against  public  policy
as  expressed  in  the  Securities  Act  and  will  be  governed  by  the  final
adjudication  of such issue.  The undertaking of the registrant in the preceding
sentence  does not  apply to  insurance  against  liability  arising  under  the
Securities Act.
SIGNATURES

The Registrant.
--------------

         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the  city of  Beaverton,  state  of  Oregon,  on the 17th day of
November, 2000.

                                           OraSure Technologies, Inc.
                                           (Registrant)

                                           By  /s/ Charles E. Bergeron
                                               -------------------------------
                                               Charles E. Bergeron
                                               Chief Financial Officer

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities indicated as of the 17th day of November, 2000.

                     Signature                               Title
                     --------                                -----
   (1)  Principal Executive Officer

   * Robert D. Thompson                     Chief Executive Officer and Director

   (2)  Principal Financial Officer

   /s/ Charles E. Bergeron
   -----------------------------------
   Charles E. Bergeron                      Vice President and
                                            Chief Financial Officer

   (3)  Principal Accounting Officer

   /s/ Theodore R. Gwin
   -----------------------------------
   Theodore R. Gwin                         Controller

   (4)  A majority of the Board of Directors

   * ROGER L. PRINGLE                       Director
   * FRANK G. HAUSMANN, JR.                 Director
   * MICHAEL G. BOLTON                      Director
   * WILLIAM W. CROUSE                      Director
   * MICHAEL J. GAUSLING                    Director

* By  /s/ Charles E. Bergeron
      --------------------------------------
     Charles E. Bergeron
     Attorney-in-fact
INDEX TO EXHIBITS

4.1      Certificate  of  Incorporation  of  the  registrant.   Incorporated  by
         reference to Exhibit 3.1 to the registrant's  Registration Statement on
         Form S-4 (File No. 333-39210) ("Form S-4").

4.1.1    Certificate of Amendment to Certificate of Incorporation  dated May 23,
         2000. Incorporated by reference to Exhibit 3.1.1 to Form S-4.

4.2      Bylaws of the  registrant.  Incorporated by reference to Exhibit 3.2 to
         Form S-4.

4.3      Rights  Agreement  dated as of May 6, 2000,  between the registrant and
         ChaseMellon Shareholder Services,  L.L.C.  Incorporated by reference to
         Exhibit 4.2 to Form S-4.

5        Opinion of Miller Nash LLP.

23.1     Consent of PricewaterhouseCoopers LLP.

23.2     Consent of Arthur Andersen LLP

23.3     Consent of Miller Nash LLP.  Included in Exhibit 5.

24       Power of attorney of certain officers and directors.

---------------

         Other exhibits listed in Item 601 to Regulation S-K are not applicable.