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<TITLE>Nuvelo, Inc. Form S-8</TITLE>
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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>


<P align="center"><FONT size="2"><B>As filed with the Securities and Exchange Commission on September&nbsp;5, 2003</B>
</FONT>

<DIV align="right"><FONT size="2"><B>Registration No.&nbsp;333- </B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></DIV>

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<P align="center"><FONT size="4"><B>SECURITIES AND EXCHANGE COMMISSION
</B></FONT>


<DIV align="center"><FONT size="3"><B>WASHINGTON, D.C. 20549</B>
</FONT></DIV>


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<P align="center"><FONT size="5"><B>FORM S-8
</B></FONT>


<P align="center"><FONT size="3"><B>REGISTRATION STATEMENT<BR>
UNDER<BR>
THE SECURITIES ACT OF 1933</B>
</FONT>


<P align="center"><HR align="center" size="1" width="20%" noshade>


<P align="center"><FONT size="6"><B>NUVELO, INC.
</B></FONT>


<DIV align="center"><FONT size="2"><B>(Exact Name of Registrant as Specified in Its Charter)</B>
</FONT></DIV>

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    <TD width="5%">&nbsp;</TD>
    <TD width="44%">&nbsp;</TD>
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    <TD align="center" valign="top"><FONT size="2"><B>Nevada<BR>
(State of Incorporation)</B></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
<B>36-3855489<BR>
(I.R.S. Employer Identification No.)</B></FONT></TD>
</TR>
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<P align="center"><FONT size="2"><B>675 Almanor Avenue<BR>
Sunnyvale, California 94086<BR>
(Address of Principal Executive Offices including Zip Code)</B>
</FONT>


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<P align="center"><FONT size="2"><B>NUVELO, INC. 2002 EQUITY INCENTIVE PLAN<BR>
MISCELLANEOUS STOCK OPTION AGREEMENTS</B>
</FONT>


<P align="center"><FONT size="2"><B>(Full Title of the Plan)</B>
</FONT>


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    <TD width="5%">&nbsp;</TD>
    <TD width="45%">&nbsp;</TD>
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<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2"><B>Ted W. Love, M.D.</B></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
<B>Copy to:</B></FONT></TD>
</TR>

<TR valign="bottom">
    <TD align="center" valign="top"><FONT size="2"><B>President and Chief Executive Officer<BR>
Nuvelo, Inc.<BR>
675 Almanor Avenue<BR>
Sunnyvale, California 94086<BR>
(408)&nbsp;524-8100</B></FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="center" valign="top"><FONT size="2">
<B>Alan C. Mendelson, Esq.<BR>
Latham &#038; Watkins<BR>
135 Commonwealth Drive<BR>
Menlo Park, California 94025<BR>
(650)&nbsp;328-4600</B></FONT></TD>
</TR>
</TABLE>
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<P align="center"><FONT size="2"><B>(Name, Address, Including Zip Code, and Telephone Number,<BR>
Including Area Code for Agent for Service)</B>
</FONT>


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<P align="center"><FONT size="2"><B>CALCULATION OF REGISTRATION FEE</B>
</FONT>

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<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
    <TD width="39%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="8%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="6%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="7%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="6%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Proposed</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Maximum</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
</TR>
<TR valign="bottom">
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Maximum</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Amount of</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>to be</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Aggregate</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registration</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Title of Securities to be Registered</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Registered(1)</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Per Share</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Offering Price</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center" colspan="3"><FONT size="1"><B>Fee</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD colspan="3"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
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    <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock, $0.001 par value per
share, issuable under the Nuvelo, Inc.
2002 Equity Incentive Plan</FONT></DIV></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">1,500,000</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">1.54</FONT></TD>
    <TD nowrap><FONT size="2">(2)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">2,335,871.43</FONT></TD>
    <TD nowrap><FONT size="2">(2)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">188.97</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR>
    <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">&nbsp;</FONT></DIV></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><HR size="1" noshade></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
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<TR valign="bottom">
    <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">Common Stock, $0.001 par value per
share, issuable under
Miscellaneous Stock Option
Agreements issued by Nuvelo, Inc. to
certain officers, employees and
directors ................(3)</FONT></DIV></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">2,443,160</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">8.89</FONT></TD>
    <TD nowrap><FONT size="2">(4)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD nowrap align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">21,719,692.40</FONT></TD>
    <TD nowrap><FONT size="2">(4)</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="right"><FONT size="2">$</FONT></TD>
    <TD align="right"><FONT size="2">1,757.12</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR>
    <TD><DIV style="margin-left:10px; text-indent:-10px"><FONT size="2">&nbsp;</FONT></DIV></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><HR size="1" noshade></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
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    <TD><FONT size="2">&nbsp;</FONT></TD>
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<P>
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<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Pursuant to Rule&nbsp;416(a), this registration statement shall also cover any
additional shares of common stock which become issuable under the Nuvelo,
Inc. 2002 Equity Incentive Plan and the stock option agreements covered
hereby by reason of any stock dividend, stock split, recapitalization or
other similar transaction effected without the receipt of consideration
which results in an increase in the number of outstanding shares of the
registrant&#146;s common stock.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Estimated for the purpose of calculating the registration fee (i)
pursuant to Rule&nbsp;457(h) under the Securities Act of 1933, as amended (the
&#147;Securities Act&#148;), on the basis of the weighted average exercise price per
share of $1.54 for 1,433,663&nbsp;shares subject to
previously granted options and (ii)&nbsp;pursuant to Rule&nbsp;457(c) under the
Securities Act for the remaining 66,337&nbsp;shares available for future grants
based on the average of the high and low prices of the registrant&#146;s common
stock as reported on the Nasdaq National Market on September&nbsp;2, 2003. The
proposed maximum offering price per share set forth represents the
per share price calculated pursuant to Rule&nbsp;457(h).</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">This registration statement covers 2,443,160 shares of the registrant&#146;s
common stock issuable to certain of the registrant&#146;s officers, employees
and directors pursuant to stock option agreements between such individuals
and the registrant.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(4)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Estimated for the purpose of calculating the registration fee pursuant to
Rule&nbsp;457(h) under the Securities Act. The price of $8.89&nbsp;per share
represents the weighted average exercise price for such previously granted
options.</FONT></TD>
</TR>
</TABLE>

<P align="center"><FONT size="2">Proposed sales to take place as soon after the effective date of the registration statement as options granted under the Plan or the Stock Option Agreements are exercised.
</FONT>


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<!-- TOC -->
<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

<P><CENTER>
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<TR><TD colspan="9"><A HREF="#000">EXPLANATORY NOTE</A></TD></TR>
<TR><TD colspan="9"><A HREF="#001">PART I</A></TD></TR>
<TR><TD colspan="9"><A HREF="#002">PART II</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#003">Item&nbsp;3. Incorporation of Documents by Reference.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#004">Item&nbsp;4. Description of Securities.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#005">Item&nbsp;5. Interests of Named Experts and Counsel.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#006">Item&nbsp;6. Indemnification of Directors and Officers.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#007">Item&nbsp;7. Exemption from Registration Claimed.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#008">Item&nbsp;8. Exhibits.</A></TD></TR>
<TR><TD></TD><TD colspan="8"><A HREF="#009">Item&nbsp;9. Undertakings.</A></TD></TR>
<TR><TD colspan="9"><A HREF="#010">SIGNATURES</A></TD></TR>
<TR><TD colspan="9"><A HREF="#011">INDEX TO EXHIBITS</A></TD></TR>
<TR><TD colspan="9"><A HREF="f92849exv5w1.txt">EXHIBIT 5.1</A></TD></TR>
<TR><TD colspan="9"><A HREF="f92849exv23w2.txt">EXHIBIT 23.2</A></TD></TR>
<TR><TD colspan="9"><A HREF="f92849exv23w3.txt">EXHIBIT 23.3</A></TD></TR>
</TABLE>
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<!-- link1 "EXPLANATORY NOTE" -->
<DIV align="left"><A NAME="000"></A></DIV>

<P align="center"><FONT size="2"><B>EXPLANATORY NOTE</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This registration statement covers 1,500,000 shares of the registrant&#146;s
common stock issuable pursuant to the Nuvelo, Inc. 2002 Equity Incentive Plan
(the &#147;Plan&#148;). This registration statement also covers 2,443,160 shares of the
registrant&#146;s common stock issuable to certain of the registrant&#146;s officers,
employees and directors pursuant to stock option agreements between such
individuals and the registrant (the &#147;Stock Option Agreements&#148;). Specifically,
the following Stock Option Agreements are covered hereby: Stock Option
Agreement dated January&nbsp;11, 2001, representing options to purchase 468,160
shares of common stock at an exercise price of $12.50 to Ted Love, M.D., the
registrant&#146;s President and Chief Executive Officer; Stock Option Agreements
dated August&nbsp;21, 2001, representing options to purchase an aggregate of
1,000,000 shares of common stock at an exercise price of $8.64 to George
Rathmann, Ph.D., the Chairman of the registrant&#146;s Board of Directors; Stock
Option Agreement dated April&nbsp;24, 2001, representing options to purchase 150,000
shares of common stock at an exercise price of $9.96 to Linda Fitzpatrick, the
registrant&#146;s Senior Vice President of Human Resources; Stock Option Agreement
dated May&nbsp;1, 2001, representing options to purchase 200,000 shares of common
stock at an exercise price of $11.67 to Peter Garcia, the registrant&#146;s Senior
Vice President and Chief Financial Officer; Stock Option Agreement dated July
15, 2001, representing options to purchase 250,000 shares of common stock at an
exercise price of $10.40 to William Bennett, the registrant&#146;s former Senior
Vice President of Research and Development; Stock Option Agreement dated June
24, 2002, representing options to purchase 175,000 shares of common stock at an
exercise price of $1.89 to Nina Giles, the registrant&#146;s Vice President of
Business Development; and Stock Option Agreement dated June&nbsp;2, 2003,
representing options to purchase 200,000 shares of common stock at an exercise
price of $2.35 to Jan Johansson, M.D., Ph.D., the registrant&#146;s Vice President
Clinical Affairs and Chief Medical Officer.
</FONT>

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<DIV align="left"><A NAME="001"></A></DIV>

<P align="center"><FONT size="2"><B>PART I</B>
</FONT>


<P align="center"><FONT size="2"><B>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The information called for in Part I of Form&nbsp;S-8 is not being filed with
or included in this Form&nbsp;S-8 (by incorporation by reference or otherwise) in
accordance with the rules and regulations of the Securities and Exchange
Commission (the &#147;SEC&#148;).
</FONT>

<P align="center"><FONT size="2">&nbsp;</FONT>

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<DIV align="left"><A NAME="002"></A></DIV>

<P align="center"><FONT size="2"><B>PART II</B>
</FONT>


<P align="center"><FONT size="2"><B>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</B>
</FONT>

<!-- link2 "Item&nbsp;3. Incorporation of Documents by Reference." -->
<DIV align="left"><A NAME="003"></A></DIV>

<P align="left"><FONT size="2"><B>Item&nbsp;3. Incorporation of Documents by Reference.</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents which the registrant filed with the SEC are
incorporated by reference into this registration statement:
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp; Annual Report on Form&nbsp;10-K for the fiscal year ended December&nbsp;31,
2002, filed with the SEC on March&nbsp;31, 2003, as amended on Form&nbsp;10-K/A filed
with the SEC on April, 30, 2003 (File No.000-22873);
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp; Quarterly Report on Form&nbsp;10-Q for the quarter ended March&nbsp;31, 2003,
filed with the SEC on May&nbsp;14, 2003 (File No.000-22873);
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp; Quarterly Report on Form&nbsp;10-Q for the quarter ended June&nbsp;30, 2003,
filed with the SEC on August&nbsp;14, 2003 (File No.000-22873);
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp; Current Report on Form&nbsp;8-K filed with the SEC on August&nbsp;12, 2003 (File
No.000-22873);
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;
Current Report on Form&nbsp;8-K filed with the SEC on February&nbsp;24, 2003
(File No.&nbsp;000-22873);
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp; Current Report on Form&nbsp;8-K filed with the SEC on February&nbsp;4, 2003, as
amended on Form&nbsp;8-K/A filed with the SEC on February&nbsp;14, 2003, as amended on
Form&nbsp;8-K/A filed with the SEC on July&nbsp;3, 2003 (File No.000-22873);
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g)&nbsp; Current Report on Form&nbsp;8-K filed with the SEC on January&nbsp;28, 2003
(File No.000-22873);
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h)&nbsp; Current Report on Form&nbsp;8-K filed with the SEC on January&nbsp;21, 2003
(File No.000-22873); and
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp; The description of common stock contained in the registration
statement on Form&nbsp;8-A (File No.&nbsp;000-22873), as filed with the SEC on July&nbsp;23,
1997, including any subsequent amendment or report filed for the purpose of
updating such description.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All documents subsequently filed pursuant to Section&nbsp;13(a), 13(c), 14 or
15(d) of the Securities Exchange Act of 1934, as amended, and prior to the
termination of the offering of the securities offered hereby shall be deemed to
be incorporated by reference into this registration statement and to be a part
hereof from the respective dates of filing of such documents. Any statement
contained in a document incorporated or deemed to be incorporated by reference
herein shall be deemed to be modified or superseded for purposes of this
registration statement to the extent that a statement contained herein, or in
any other subsequently filed document that also is or is deemed to be
incorporated by reference herein, modifies or supersedes such statement. Any
such statement so modified or superseded shall not be deemed, except as so
modified or superseded, to constitute a part of this registration statement.
</FONT>

<!-- link2 "Item&nbsp;4. Description of Securities." -->
<DIV align="left"><A NAME="004"></A></DIV>

<P align="left"><FONT size="2"><B>Item&nbsp;4. Description of Securities.</B>
</FONT>

<P align="left"><FONT size="2">Not Applicable.
</FONT>

<!-- link2 "Item&nbsp;5. Interests of Named Experts and Counsel." -->
<DIV align="left"><A NAME="005"></A></DIV>

<P align="left"><FONT size="2"><B>Item&nbsp;5. Interests of Named Experts and Counsel.</B>
</FONT>

<P align="left"><FONT size="2">Not Applicable.
</FONT>

<P align="center"><FONT size="2">&nbsp;</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link2 "Item&nbsp;6. Indemnification of Directors and Officers." -->
<DIV align="left"><A NAME="006"></A></DIV>

<P align="left"><FONT size="2"><B>Item&nbsp;6. Indemnification of Directors and Officers.</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with Nevada law, the registrant&#146;s articles of incorporation
provide that none of its officers or directors shall be personally liable to
the registrant or any of its stockholders for damages for breach of fiduciary
duty as an officer or director. However, this provision excludes any limitation
on liability for (i)&nbsp;acts or omissions which involve intentional misconduct,
fraud or a knowing violation of law, or (ii)&nbsp;the payment of distributions in
violation of Nevada law.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In accordance with Nevada law, the registrant&#146;s by-laws provide that the
registrant shall indemnify any person who was or is a party or is threatened to
be made a party to, or otherwise becomes involved in, any proceeding (other
than an action by or in the right of the registrant) by reason of the fact that
he is or was an officer, director or agent of the registrant against losses
actually and reasonably incurred by that person if the person acted in good
faith and in a manner the person reasonably believed to be in or not opposed to
the registrant&#146;s best interests. Losses are the total amount that the officer,
director or agent becomes legally obligated to pay, including judgments, fines,
amounts paid in settlement, attorneys&#146; fees, expenses of establishing a right
to indemnification and other expenses. If the proceeding is a criminal
proceeding, the person to be indemnified must have had no reasonable cause to
believe his or her conduct was unlawful.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The registrant&#146;s bylaws provide for similar indemnification for expenses
resulting from an action by or in the right of the registrant, except that no
indemnification will be made if the person is adjudged by a court of competent
jurisdiction after exhaustion of all appeals to be liable to the registrant or
for amounts paid in settlement to the registrant unless the court determines
that the person is fairly and reasonably entitled to indemnity for expenses.
Expenses of officers, directors and agents include attorneys&#146; fees, any
expenses of establishing a right to indemnification and amounts paid in
settlement. Our bylaws also provide for advancement of expenses.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The registrant also maintains liability insurance for its officers and
directors, and has entered into indemnification agreements with them.
</FONT>

<!-- link2 "Item&nbsp;7. Exemption from Registration Claimed." -->
<DIV align="left"><A NAME="007"></A></DIV>

<P align="left"><FONT size="2"><B>Item&nbsp;7. Exemption from Registration Claimed.</B>
</FONT>

<P align="left"><FONT size="2">Not Applicable.
</FONT>

<!-- link2 "Item&nbsp;8. Exhibits." -->
<DIV align="left"><A NAME="008"></A></DIV>

<P align="left"><FONT size="2"><B>Item&nbsp;8. Exhibits.</B>
</FONT>

<P align="left"><FONT size="2">See the Index to Exhibits located after the signature pages.
</FONT>

<!-- link2 "Item&nbsp;9. Undertakings." -->
<DIV align="left"><A NAME="009"></A></DIV>

<P align="left"><FONT size="2"><B>Item&nbsp;9. Undertakings.</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp; The undersigned registrant hereby undertakes:
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:
</FONT>


<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;To include any prospectus required by Section&nbsp;10(a)(3) of the
Securities Act;
</FONT>


<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;To reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in the volume of
securities offered (if the total dollar value of securities offered would not
exceed that which was registered) and any deviation from the low or high end of
the estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule&nbsp;424(b) if, in the aggregate, the
changes in volume and price represent no more than 20&nbsp;percent change in the
maximum aggregate offering price set forth in the &#147;Calculation of Registration
Fee&#148; table in the effective registration statement.
</FONT>


<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement;
</FONT>

<P align="center"><FONT size="2">&nbsp;</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<P align="left"><FONT size="2">provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
registration statement is on Form&nbsp;S-3 or Form&nbsp;S-8, and the information required
to be included in a post-effective amendment by those paragraphs is contained
in periodic reports filed by the registrant pursuant to Section&nbsp;13 or Section
15(d) of the Exchange
Act that are incorporated by reference in the registration statement.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of
the offering.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp; The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant&#146;s annual report pursuant to Section&nbsp;13(a) or Section&nbsp;15(d) of the
Exchange Act that is incorporated by reference in the registration statement
shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp; Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to officers, directors, and controlling persons
of the registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the SEC such indemnification
is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the registrant of expenses incurred or
paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer, or controlling person in connection with the securities
being registered, the registrant will, unless in the opinion of its counsel the
matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is
against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.
</FONT>

<P align="center"><FONT size="2">&nbsp;</FONT>

<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "SIGNATURES" -->
<DIV align="left"><A NAME="010"></A></DIV>

<P align="center"><FONT size="2"><B>SIGNATURES</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form&nbsp;S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Sunnyvale, State of California, on this 5th day of
September 2003.
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
    <TD width="45%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="2%">&nbsp;</TD>
    <TD width="49%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD colspan="3" valign="top" align="left"><FONT size="2">Nuvelo, Inc.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
By:</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">/s/ Ted W. Love</FONT></TD>
</TR>
<TR>
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">Ted W. Love, M.D.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">President and Chief Executive Officer</FONT></TD>
</TR>
</TABLE>
</CENTER>

<P align="center"><FONT size="2"><B>POWER OF ATTORNEY</B>
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each person whose signature appears below constitutes and appoints Ted W.
Love and Peter S. Garcia, and each or any of them, his true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution,
for him and in his name, place and stead in any and all capacities, to sign any
and all amendments (including post-effective amendments) and other documents in
connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that said attorneys-in-fact and agents or any of them, or their or his
substitute or substitutes, may lawfully do or cause to be done by virtue
hereof.
</FONT>

<P align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act, this registration
statement has been signed by the following persons in the capacities and on the
dates indicated.
</FONT>


<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="95%">
<TR valign="bottom">
    <TD width="33%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="44%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="17%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><FONT size="1"><B>Signature</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Title</B></FONT></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><FONT size="1"><B>Date</B></FONT></TD>
</TR>
<TR valign="bottom">
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
    <TD><FONT size="1">&nbsp;</FONT></TD>
    <TD nowrap align="center"><HR size="1" noshade></TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Ted W. Love<BR></FONT>
<HR size="1" noshade><FONT size="2">
Ted W. Love, M.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
President, Chief Executive Officer and<BR>
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">September 5, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Peter S. Garcia<BR></FONT>
<HR size="1" noshade><FONT size="2">
Peter S. Garcia</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Senior Vice President and Chief<BR>
Financial Officer (Principal Financial<BR>
and Accounting Officer)
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">September 5, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ George B. Rathmann<BR></FONT>
<HR size="1" noshade><FONT size="2">
George B. Rathmann, Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Chairman of the Board of Directors
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">September 5, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Mary K. Pendergast<BR></FONT>
<HR size="1" noshade><FONT size="2">
Mary K. Pendergast</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">September 5, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
Thomas N. McCarter III</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Philippe O. Chambon<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
Philippe O. Chambon, M.D., Ph.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">September 5, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Jean-Francois Formela<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
Jean-Francois Formela, M.D.</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">September 5, 2003</FONT></TD>
</TR>
<TR><TD><FONT size="2">&nbsp;</FONT></TD></TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">/s/ Martin A. Vogelbaum<BR>
</FONT>
<HR size="1" noshade><FONT size="2">
Martin A. Vogelbaum</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Director
</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">September 5, 2003</FONT></TD>
</TR>
</TABLE>
</CENTER>
<P align="center"><FONT size="2">&nbsp;</FONT>


<!-- PAGEBREAK -->
<P><HR noshade><P>
<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<!-- link1 "INDEX TO EXHIBITS" -->
<DIV align="left"><A NAME="011"></A></DIV>

<P align="center"><FONT size="2"><B>INDEX TO EXHIBITS</B>
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="95%">
<TR valign="bottom">
    <TD width="6%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="91%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Nuvelo, Inc. 2002 Equity Incentive Plan. (1)</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Form of Non-Stockholder Approved Option Agreement for Officers. (2)</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">4.3</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Stock Option Agreement, dated as of September&nbsp;21, 2001, between Hyseq, Inc. and Dr.&nbsp;George B. Rathmann. (3)</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">5.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Opinion of Kummer Kaempfer Bonner &#038; Renshaw.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">23.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of Kummer Kaempfer Bonner &#038; Renshaw (included in Exhibit&nbsp;5.1).</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">23.2</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of KPMG LLP, Independent Auditors.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">23.3</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Consent of PricewaterhouseCoopers LLP, Independent Accountants.</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">&nbsp;</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR valign="bottom">
    <TD valign="top"><FONT size="2">24.1</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
Power of Attorney (included on signature page of this registration statement).</FONT></TD>
</TR>
</TABLE>
</CENTER>

<P>
<HR size="1" width="18%" align="left" noshade>
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(1)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Incorporated by reference to Appendix&nbsp;A to the registrant&#146;s Definitive Proxy Statement on Schedule&nbsp;14A, filed on June&nbsp;13, 2002, File No.&nbsp;000-22873.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(2)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Incorporated by reference to Exhibit&nbsp;10.27 to the registrant&#146;s Annual Report on Form&nbsp;10-K/A for the year ended December&nbsp;31, 2001, filed on May&nbsp;9, 2002, File No.&nbsp;000-22873.</FONT></TD>
</TR>
<TR>
    <TD><FONT size="2">&nbsp;</FONT></TD>
</TR>
<TR valign="top">
    <TD width="1%" align="left" nowrap><FONT size="2">(3)</FONT></TD>
    <TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
    <TD width="96%"><FONT size="2">Incorporated by reference to Exhibit&nbsp;10.26 to the registrant&#146;s Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 2001, filed on April&nbsp;1, 2002, File No.&nbsp;000-22873.</FONT></TD>
</TR>
</TABLE>


<P align="center"><FONT size="2">&nbsp;</FONT>



</BODY>
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Nuvelo, Inc. Form S-8
Table of Contents
As filed with the Securities and Exchange Commission on September 5, 2003
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
NUVELO, INC.
(Exact Name of Registrant as Specified in Its Charter)
Nevada
(State of Incorporation)
36-3855489
(I.R.S. Employer Identification No.)
675 Almanor Avenue
Sunnyvale, California 94086
(Address of Principal Executive Offices including Zip Code)
NUVELO, INC. 2002 EQUITY INCENTIVE PLAN
MISCELLANEOUS STOCK OPTION AGREEMENTS
(Full Title of the Plan)
Ted W. Love, M.D.
Copy to:
President and Chief Executive Officer
Nuvelo, Inc.
675 Almanor Avenue
Sunnyvale, California 94086
(408) 524-8100
Alan C. Mendelson, Esq.
Latham & Watkins
135 Commonwealth Drive
Menlo Park, California 94025
(650) 328-4600
(Name, Address, Including Zip Code, and Telephone Number,
Including Area Code for Agent for Service)
CALCULATION OF REGISTRATION FEE
Proposed
Maximum
Amount
Maximum
Amount of
Amount of
to be
Offering Price
Aggregate
Registration
Title of Securities to be Registered
Registered(1)
Per Share
Offering Price
Fee
Common Stock, $0.001 par value per
share, issuable under the Nuvelo, Inc.
2002 Equity Incentive Plan
1,500,000
$
1.54
(2)
$
2,335,871.43
(2)
$
188.97
Common Stock, $0.001 par value per
share, issuable under
Miscellaneous Stock Option
Agreements issued by Nuvelo, Inc. to
certain officers, employees and
directors ................(3)
2,443,160
$
8.89
(4)
$
21,719,692.40
(4)
$
1,757.12
(1)
Pursuant to Rule 416(a), this registration statement shall also cover any
additional shares of common stock which become issuable under the Nuvelo,
Inc. 2002 Equity Incentive Plan and the stock option agreements covered
hereby by reason of any stock dividend, stock split, recapitalization or
other similar transaction effected without the receipt of consideration
which results in an increase in the number of outstanding shares of the
registrant's common stock.
(2)
Estimated for the purpose of calculating the registration fee (i)
pursuant to Rule 457(h) under the Securities Act of 1933, as amended (the
"Securities Act"), on the basis of the weighted average exercise price per
share of $1.54 for 1,433,663 shares subject to
previously granted options and (ii) pursuant to Rule 457(c) under the
Securities Act for the remaining 66,337 shares available for future grants
based on the average of the high and low prices of the registrant's common
stock as reported on the Nasdaq National Market on September 2, 2003. The
proposed maximum offering price per share set forth represents the
per share price calculated pursuant to Rule 457(h).
(3)
This registration statement covers 2,443,160 shares of the registrant's
common stock issuable to certain of the registrant's officers, employees
and directors pursuant to stock option agreements between such individuals
and the registrant.
(4)
Estimated for the purpose of calculating the registration fee pursuant to
Rule 457(h) under the Securities Act. The price of $8.89 per share
represents the weighted average exercise price for such previously granted
options.
Proposed sales to take place as soon after the effective date of the registration statement as options granted under the Plan or the Stock Option Agreements are exercised.
TABLE OF CONTENTS
EXPLANATORY NOTE
PART I
PART II
Item 3. Incorporation of Documents by Reference.
Item 4. Description of Securities.
Item 5. Interests of Named Experts and Counsel.
Item 6. Indemnification of Directors and Officers.
Item 7. Exemption from Registration Claimed.
Item 8. Exhibits.
Item 9. Undertakings.
SIGNATURES
INDEX TO EXHIBITS
EXHIBIT 5.1
EXHIBIT 23.2
EXHIBIT 23.3
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EXPLANATORY NOTE
This registration statement covers 1,500,000 shares of the registrant's
common stock issuable pursuant to the Nuvelo, Inc. 2002 Equity Incentive Plan
(the "Plan"). This registration statement also covers 2,443,160 shares of the
registrant's common stock issuable to certain of the registrant's officers,
employees and directors pursuant to stock option agreements between such
individuals and the registrant (the "Stock Option Agreements"). Specifically,
the following Stock Option Agreements are covered hereby: Stock Option
Agreement dated January 11, 2001, representing options to purchase 468,160
shares of common stock at an exercise price of $12.50 to Ted Love, M.D., the
registrant's President and Chief Executive Officer; Stock Option Agreements
dated August 21, 2001, representing options to purchase an aggregate of
1,000,000 shares of common stock at an exercise price of $8.64 to George
Rathmann, Ph.D., the Chairman of the registrant's Board of Directors; Stock
Option Agreement dated April 24, 2001, representing options to purchase 150,000
shares of common stock at an exercise price of $9.96 to Linda Fitzpatrick, the
registrant's Senior Vice President of Human Resources; Stock Option Agreement
dated May 1, 2001, representing options to purchase 200,000 shares of common
stock at an exercise price of $11.67 to Peter Garcia, the registrant's Senior
Vice President and Chief Financial Officer; Stock Option Agreement dated July
15, 2001, representing options to purchase 250,000 shares of common stock at an
exercise price of $10.40 to William Bennett, the registrant's former Senior
Vice President of Research and Development; Stock Option Agreement dated June
24, 2002, representing options to purchase 175,000 shares of common stock at an
exercise price of $1.89 to Nina Giles, the registrant's Vice President of
Business Development; and Stock Option Agreement dated June 2, 2003,
representing options to purchase 200,000 shares of common stock at an exercise
price of $2.35 to Jan Johansson, M.D., Ph.D., the registrant's Vice President
Clinical Affairs and Chief Medical Officer.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
The information called for in Part I of Form S-8 is not being filed with
or included in this Form S-8 (by incorporation by reference or otherwise) in
accordance with the rules and regulations of the Securities and Exchange
Commission (the "SEC").
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PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents by Reference.
The following documents which the registrant filed with the SEC are
incorporated by reference into this registration statement:
(a)  Annual Report on Form 10-K for the fiscal year ended December 31,
2002, filed with the SEC on March 31, 2003, as amended on Form 10-K/A filed
with the SEC on April, 30, 2003 (File No.000-22873);
(b)  Quarterly Report on Form 10-Q for the quarter ended March 31, 2003,
filed with the SEC on May 14, 2003 (File No.000-22873);
(c)  Quarterly Report on Form 10-Q for the quarter ended June 30, 2003,
filed with the SEC on August 14, 2003 (File No.000-22873);
(d)  Current Report on Form 8-K filed with the SEC on August 12, 2003 (File
No.000-22873);
(e) 
Current Report on Form 8-K filed with the SEC on February 24, 2003
(File No. 000-22873);
(f)  Current Report on Form 8-K filed with the SEC on February 4, 2003, as
amended on Form 8-K/A filed with the SEC on February 14, 2003, as amended on
Form 8-K/A filed with the SEC on July 3, 2003 (File No.000-22873);
(g)  Current Report on Form 8-K filed with the SEC on January 28, 2003
(File No.000-22873);
(h)  Current Report on Form 8-K filed with the SEC on January 21, 2003
(File No.000-22873); and
(i)  The description of common stock contained in the registration
statement on Form 8-A (File No. 000-22873), as filed with the SEC on July 23,
1997, including any subsequent amendment or report filed for the purpose of
updating such description.
All documents subsequently filed pursuant to Section 13(a), 13(c), 14 or
15(d) of the Securities Exchange Act of 1934, as amended, and prior to the
termination of the offering of the securities offered hereby shall be deemed to
be incorporated by reference into this registration statement and to be a part
hereof from the respective dates of filing of such documents. Any statement
contained in a document incorporated or deemed to be incorporated by reference
herein shall be deemed to be modified or superseded for purposes of this
registration statement to the extent that a statement contained herein, or in
any other subsequently filed document that also is or is deemed to be
incorporated by reference herein, modifies or supersedes such statement. Any
such statement so modified or superseded shall not be deemed, except as so
modified or superseded, to constitute a part of this registration statement.
Item 4. Description of Securities.
Not Applicable.
Item 5. Interests of Named Experts and Counsel.
Not Applicable.
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Item 6. Indemnification of Directors and Officers.
In accordance with Nevada law, the registrant's articles of incorporation
provide that none of its officers or directors shall be personally liable to
the registrant or any of its stockholders for damages for breach of fiduciary
duty as an officer or director. However, this provision excludes any limitation
on liability for (i) acts or omissions which involve intentional misconduct,
fraud or a knowing violation of law, or (ii) the payment of distributions in
violation of Nevada law.
In accordance with Nevada law, the registrant's by-laws provide that the
registrant shall indemnify any person who was or is a party or is threatened to
be made a party to, or otherwise becomes involved in, any proceeding (other
than an action by or in the right of the registrant) by reason of the fact that
he is or was an officer, director or agent of the registrant against losses
actually and reasonably incurred by that person if the person acted in good
faith and in a manner the person reasonably believed to be in or not opposed to
the registrant's best interests. Losses are the total amount that the officer,
director or agent becomes legally obligated to pay, including judgments, fines,
amounts paid in settlement, attorneys' fees, expenses of establishing a right
to indemnification and other expenses. If the proceeding is a criminal
proceeding, the person to be indemnified must have had no reasonable cause to
believe his or her conduct was unlawful.
The registrant's bylaws provide for similar indemnification for expenses
resulting from an action by or in the right of the registrant, except that no
indemnification will be made if the person is adjudged by a court of competent
jurisdiction after exhaustion of all appeals to be liable to the registrant or
for amounts paid in settlement to the registrant unless the court determines
that the person is fairly and reasonably entitled to indemnity for expenses.
Expenses of officers, directors and agents include attorneys' fees, any
expenses of establishing a right to indemnification and amounts paid in
settlement. Our bylaws also provide for advancement of expenses.
The registrant also maintains liability insurance for its officers and
directors, and has entered into indemnification agreements with them.
Item 7. Exemption from Registration Claimed.
Not Applicable.
Item 8. Exhibits.
See the Index to Exhibits located after the signature pages.
Item 9. Undertakings.
(a)  The undersigned registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:
(i) To include any prospectus required by Section 10(a)(3) of the
Securities Act;
(ii) To reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in the volume of
securities offered (if the total dollar value of securities offered would not
exceed that which was registered) and any deviation from the low or high end of
the estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
changes in volume and price represent no more than 20 percent change in the
maximum aggregate offering price set forth in the "Calculation of Registration
Fee" table in the effective registration statement.
(iii) To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement;
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provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
registration statement is on Form S-3 or Form S-8, and the information required
to be included in a post-effective amendment by those paragraphs is contained
in periodic reports filed by the registrant pursuant to Section 13 or Section
15(d) of the Exchange
Act that are incorporated by reference in the registration statement.
(2) That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.
(3) To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of
the offering.
(b)  The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act that is incorporated by reference in the registration statement
shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.
(c)  Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to officers, directors, and controlling persons
of the registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the SEC such indemnification
is against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the registrant of expenses incurred or
paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer, or controlling person in connection with the securities
being registered, the registrant will, unless in the opinion of its counsel the
matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question whether such indemnification by it is
against public policy as expressed in the Securities Act and will be governed
by the final adjudication of such issue.
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SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Sunnyvale, State of California, on this 5th day of
September 2003.
Nuvelo, Inc.
By:
/s/ Ted W. Love
Ted W. Love, M.D.
President and Chief Executive Officer
POWER OF ATTORNEY
Each person whose signature appears below constitutes and appoints Ted W.
Love and Peter S. Garcia, and each or any of them, his true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution,
for him and in his name, place and stead in any and all capacities, to sign any
and all amendments (including post-effective amendments) and other documents in
connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in and about the premises, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that said attorneys-in-fact and agents or any of them, or their or his
substitute or substitutes, may lawfully do or cause to be done by virtue
hereof.
Pursuant to the requirements of the Securities Act, this registration
statement has been signed by the following persons in the capacities and on the
dates indicated.
Signature
Title
Date
/s/ Ted W. Love
Ted W. Love, M.D.
President, Chief Executive Officer and
Director
September 5, 2003
/s/ Peter S. Garcia
Peter S. Garcia
Senior Vice President and Chief
Financial Officer (Principal Financial
and Accounting Officer)
September 5, 2003
/s/ George B. Rathmann
George B. Rathmann, Ph.D.
Chairman of the Board of Directors
September 5, 2003
/s/ Mary K. Pendergast
Mary K. Pendergast
Director
September 5, 2003
Thomas N. McCarter III
Director
/s/ Philippe O. Chambon
Philippe O. Chambon, M.D., Ph.D.
Director
September 5, 2003
/s/ Jean-Francois Formela
Jean-Francois Formela, M.D.
Director
September 5, 2003
/s/ Martin A. Vogelbaum
Martin A. Vogelbaum
Director
September 5, 2003
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INDEX TO EXHIBITS
4.1
Nuvelo, Inc. 2002 Equity Incentive Plan. (1)
4.2
Form of Non-Stockholder Approved Option Agreement for Officers. (2)
4.3
Stock Option Agreement, dated as of September 21, 2001, between Hyseq, Inc. and Dr. George B. Rathmann. (3)
5.1
Opinion of Kummer Kaempfer Bonner & Renshaw.
23.1
Consent of Kummer Kaempfer Bonner & Renshaw (included in Exhibit 5.1).
23.2
Consent of KPMG LLP, Independent Auditors.
23.3
Consent of PricewaterhouseCoopers LLP, Independent Accountants.
24.1
Power of Attorney (included on signature page of this registration statement).
(1)
Incorporated by reference to Appendix A to the registrant's Definitive Proxy Statement on Schedule 14A, filed on June 13, 2002, File No. 000-22873.
(2)
Incorporated by reference to Exhibit 10.27 to the registrant's Annual Report on Form 10-K/A for the year ended December 31, 2001, filed on May 9, 2002, File No. 000-22873.
(3)
Incorporated by reference to Exhibit 10.26 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2001, filed on April 1, 2002, File No. 000-22873.