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      <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on November 12, 2024</div>
      <div><br>
      </div>
      <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div><br>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div><br>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 24pt; font-weight: bold;">SANGAMO THERAPEUTICS, INC.</div>
      <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zf6f613440f4546079adddf23fd907f86" border="0" cellpadding="0" cellspacing="0">

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            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: middle;">&#160;</td>
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            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">Delaware</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">68-0359556</div>
            </td>
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            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">(State or other jurisdiction of</div>
              <div style="text-align: center; color: #000000; font-weight: bold;">&#160;incorporation or organization)</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">(I.R.S. Employer</div>
              <div style="text-align: center; color: #000000; font-weight: bold;">&#160;Identification No.)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: middle;">&#160;</td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: middle;">&#160;</td>
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            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">501 Canal Blvd.</div>
              <div style="text-align: center; color: #000000; font-weight: bold;">&#160;Richmond, California</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: bottom;">
              <div style="text-align: center; color: #000000; font-weight: bold;">94084</div>
            </td>
          </tr>
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            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">(Address of Principal Executive Offices)</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">(Zip Code)</div>
            </td>
          </tr>

      </table>
      <div style="text-align: center; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; font-weight: bold;">Amended and Restated Sangamo Therapeutics, Inc. 2018 Equity Incentive Plan</div>
      <div style="text-align: center; font-weight: bold;">(Full title of the plan)</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Alexander D. Macrae</div>
      <div style="text-align: center; font-weight: bold;">President and Chief Executive Officer</div>
      <div style="text-align: center; font-weight: bold;">Sangamo Therapeutics, Inc.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">501 Canal Blvd.</div>
      <div style="text-align: center; font-weight: bold;">Richmond, California 94084</div>
      <div style="text-align: center; font-weight: bold;">(510) 970-6000</div>
      <div style="text-align: center; font-weight: bold;">(Name and address of agent for service) (telephone number, including area code, of agent for service)</div>
      <div><br>
      </div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">Copies to:</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z5d0e3534f23e496599bc8bfcc3b81ea5" border="0" cellpadding="0" cellspacing="0">

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            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Scott Willoughby</div>
              <div style="text-align: center; font-weight: bold;">&#160;Senior Vice President and General Counsel</div>
              <div style="text-align: center; text-indent: 6.1pt; color: #000000; font-weight: bold;">&#160;Sangamo Therapeutics, Inc.</div>
              <div>
                <div style="text-align: center; font-weight: bold;">&#160;501 Canal Blvd.</div>
              </div>
              <div style="text-align: center; text-indent: 6.1pt; font-weight: bold;">&#160;Richmond, California 94084</div>
              <div>
                <div style="text-align: center; color: #000000; font-weight: bold;">&#160;(510) 970-6000</div>
              </div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Chadwick L. Mills</div>
              <div style="text-align: center; font-weight: bold;">&#160;Courtney M.W. Tygesson</div>
              <div style="text-align: center; font-weight: bold;">&#160;Cooley LLP</div>
              <div style="text-align: center; font-weight: bold;">&#160;3 Embarcadero Center, 20th Floor</div>
              <div style="text-align: center; font-weight: bold;">&#160;San Francisco, CA&#160; 94111</div>
              <div style="text-align: center; font-weight: bold;">&#160;(415) 693-2000</div>
            </td>
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      <div> <br>
      </div>
      <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
        filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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            <td style="width: 15.83%; vertical-align: middle;">&#160;</td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 59.86%; vertical-align: middle;">&#160;</td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 19%; vertical-align: middle;">&#160;</td>
            <td style="width: 0.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 1.96%; vertical-align: middle;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 15.83%; vertical-align: bottom;">
              <div style="color: #000000;">Large accelerated filer</div>
            </td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 59.86%; vertical-align: bottom;">
              <div style="color: #000000; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
            </td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 19%; vertical-align: bottom;">
              <div style="color: #000000;">Accelerated filer</div>
            </td>
            <td style="width: 0.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 1.96%; vertical-align: bottom;">
              <div style="color: #000000; font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</div>
            </td>
          </tr>
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            <td style="width: 15.83%; vertical-align: bottom;">
              <div style="color: #000000;">Non-accelerated filer</div>
            </td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 59.86%; vertical-align: bottom;">
              <div style="color: #000000; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
            </td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 19%; vertical-align: bottom;">
              <div style="color: #000000;">Smaller reporting company</div>
            </td>
            <td style="width: 0.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 1.96%; vertical-align: bottom;">
              <div style="color: #000000; font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 15.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 59.86%; vertical-align: bottom;">&#160;</td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 19%; vertical-align: bottom;">
              <div style="color: #000000;">Emerging growth company</div>
            </td>
            <td style="width: 0.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 1.96%; vertical-align: bottom;">
              <div style="color: #000000; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
            </td>
          </tr>

      </table>
      <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
        Securities Act. &#9744;</div>
      <div>
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      <div style="text-align: center; font-weight: bold;"> <br>
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      <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
      <div><br>
      </div>
      <div>This Registration Statement on Form S-8 is being filed by Sangamo Therapeutics, Inc. (the &#8220;Registrant&#8221;) with the Securities and Exchange Commission (the &#8220;Commission&#8221;) for the purpose of registering an additional 11,000,000 shares of the
        Registrant&#8217;s common stock, par value $0.01 per share (the &#8220;Common Stock&#8221;), to be issued pursuant to the Registrant&#8217;s Amended and Restated 2018 Equity Incentive Plan (the &#8220;2018 Plan&#8221;).&#160; The Registrant previously registered (i) 19,131,725 shares of
        Common Stock that are or may become issuable under the 2018 Plan pursuant to the Registrant&#8217;s registration statement on <a href="https://www.sec.gov/Archives/edgar/data/1001233/000119312518189435/d603403ds8.htm">Form S-8</a> (File No. 333-225552)
        filed with the Commission on June 11, 2018 (the &#8220;2018 Form S-8&#8221;), (ii) 9,900,000 shares of Common Stock that are or may become issuable under the 2018 Plan pursuant to the Registrant&#8217;s registration statement on <a href="https://www.sec.gov/Archives/edgar/data/1001233/000119312520210798/d24713ds8.htm">Form S-8</a> (File No. 333-241033) filed with the Commission on August 5, 2020 (the &#8220;2020 Form S-8&#8221;), (iii) 7,900,000 shares of Common Stock that are or may
        become issuable under the 2018 Plan pursuant to the Registrant&#8217;s registration statement on <a href="https://www.sec.gov/Archives/edgar/data/1001233/000119312523045598/d469019ds8.htm">Form S-8</a> (File No. 333-269925) filed with the Commission on
        February 23, 2023 (the &#8220;2023 Form S-8&#8221;), and (iv) 10,000,000 shares of Common Stock that are or may become issuable under the 2018 Plan pursuant to the Registrant&#8217;s registration statement on <a href="https://www.sec.gov/Archives/edgar/data/1001233/000119312523206301/d499172ds8.htm">Form S-8</a> (File No. 333-273805) filed with the Commission on August 8, 2023 (together with the 2018 Form S-8, the 2020 Form S-8, and the 2023 Form S-8,
        the &#8220;Prior Registration Statements&#8221;). This<font style="color: #000000;"> Registration Statement relates to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with General
          Instruction E of Form S-8. Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements are incorporated by reference herein.</font></div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">PART II</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
      <div><br>
      </div>
      <div><font style="font-weight: bold;">Item 3.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Incorporation of Documents by Reference</font></div>
      <div><br>
      </div>
      <div>The following documents filed by the Registrant with the Commission are incorporated by reference into this Registration Statement:</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z15e5a372e36347edb70f98689f1aeb0c" cellpadding="0" cellspacing="0">

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            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="color: #000000;">the Registrant&#8217;s annual report on Form 10-K for the year ended December 31, 2023, which was filed with the Commission on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024010788/sgmo-20231231.htm">March 13, 2024</a><font style="color: #000000;">;</font></div>
            </td>
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      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z069850e938ba45278e258019f5cd962d" cellpadding="0" cellspacing="0">

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            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="color: #000000;">the information specifically incorporated by reference into the Registrant&#8217;s annual report on Form 10-K for the year ended December 31, 2023 from the Registrant&#8217;s definitive proxy statement on </font>Schedule








                14A<font style="color: #000000;">, which was filed with the Commission on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024016932/sgmo-20240419.htm">April 19, 2024</a><font style="color: #000000;">;</font></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z8d9ac4cf5f87419eaec5c357b1c28917" cellpadding="0" cellspacing="0">

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            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="color: #000000;">the Registrant&#8217;s quarterly reports on </font>Form 10-Q<font style="color: #000000;"> for the quarters ended March 31, 2024, June 30, 2024 and September 30, 2024, which were filed with the Commission on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024022194/sgmo-20240331.htm">May 9, 2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024035165/sgmo-20240630.htm">August 6,
                  2024</a> and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1001233/000162828024047102/sgmo-20240930.htm">November 12, 2024</a>, respectively<font style="color: #000000;">;</font></div>
            </td>
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      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf61f6b632e7f4314881d3dff1b83e1f8" cellpadding="0" cellspacing="0">

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            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="color: #000000;">the Registrant&#8217;s current reports on Form 8-K, which were filed with the Commission on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024001784/sgmo-20240119.htm">January
                  19, 2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024003506/sgmo-20240205.htm">February 6, 2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000119312524076613/d816036d8k.htm">March 25, 2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024019337/sgmo-20240424.htm">April 30,
                  2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024026903/sgmo-20240604.htm">June 5, 2024</a> and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024032815/sgmo-20240724.htm">July 24, 2024</a><font style="color: #000000;">; and</font></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd5350c089f9b4ec8a2e419663bba1109" cellpadding="0" cellspacing="0">

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            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="color: #000000;">the description of the Common Stock contained in the Registrant&#8217;s registration statement on </font><a href="https://www.sec.gov/Archives/edgar/data/1001233/000095014900000735/0000950149-00-000735.txt">Form
                  8-A</a><font style="color: #000000;">, which was filed with the Commission on March 31, 2000, including all amendments and reports filed for the purpose of updating such description, including </font><a href="https://www.sec.gov/Archives/edgar/data/1001233/000162828024010788/sgmo-20231231xex41.htm">Exhibit 4.1</a> <font style="color: #000000;">of the Registrant&#8217;s annual report on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1001233/000162828024010788/sgmo-20231231.htm">Form 10-K</a><font style="color: #000000;"> for the year ended December 31, 2023.</font></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div>All reports and other documents filed by the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits
        furnished on such form that relate to such items, after the date of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all
        securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of filing such reports and documents. Any statement contained in a document incorporated or
        deemed to be incorporated herein by reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement herein or in any other subsequently filed document which also is or is deemed to
        be incorporated by reference herein modifies or supersedes that statement. Any such statement so modified or superseded shall not constitute a part of this Registration Statement, except as so modified or superseded.</div>
      <div><br>
      </div>
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            <td style="width: 72pt; vertical-align: top; font-weight: bold;">Item 8.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">Exhibits</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z902656b5377a420d99980218b11ec159" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 8.42%; vertical-align: middle;">&#160;</td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: middle;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: bottom; border-bottom: 2px solid black;" nowrap="nowrap">
              <div style="text-align: center; color: #000000; font-weight: bold;">Exhibit</div>
              <div style="text-align: center; color: #000000; font-weight: bold;">Number</div>
            </td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: bottom; border-bottom: 2px solid black;" nowrap="nowrap">
              <div style="color: #000000; font-weight: bold;">Description</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: middle;">&#160;</td>
            <td colspan="2" style="width: 91.58%; vertical-align: middle;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1001233/000162828023020692/sgmo-20230602xex33.htm">4.1</a></div>
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            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1001233/000162828024026903/sgmo-20240605xex31.htm">4.2</a></div>
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              <div>Certificate of Amendment of the Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current Report on Form 8-K filed June 5, 2024).</div>
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            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1001233/000162828022032209/sgmo-20221219xxex31fifth.htm">4.3</a></div>
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              <div style="text-align: center; color: #000000;"><a href="ny20037443x2_ex23-1.htm">23.1</a></div>
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            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
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              <div style="text-align: center; color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1001233/000162828024026903/ex-101amendedandrestated.htm">99.1</a></div>
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              <div>Amended and Restated Sangamo Therapeutics, Inc. 2018 Equity Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrant&#8217;s Current Report on Form 8-K filed June 5, 2024).</div>
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              <div style="text-align: center; color: #000000;"><a href="ny20037443x2_ex107.htm">107</a></div>
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              <div>Filing fee table.</div>
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      <div>Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration
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            <td style="width: 9.48%; vertical-align: middle;">&#160;</td>
            <td style="width: 1%; vertical-align: bottom;">&#160;</td>
            <td style="width: 89.53%; vertical-align: middle;">&#160;</td>
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              <div style="color: #000000; font-weight: bold;">SANGAMO THERAPEUTICS, INC.</div>
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            <td colspan="2" style="width: 90.52%; vertical-align: middle;">&#160;</td>
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            <td style="width: 9.48%; vertical-align: top;">&#160;</td>
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      <div style="text-align: center; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
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      <div>KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Alexander D. Macrae, Prathyusha Duraibabu and Scott Willoughby, and each of them, as his or her true and lawful attorney-in-fact and agent with
        the full power of substitution and resubstitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this registration statement (including post-effective amendments), and to file
        the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing
        requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his or her substitute or
        substitutes, may lawfully do or cause to be done by virtue hereof.</div>
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      <div>Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the date indicated.</div>
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              <td rowspan="1" style="width: 26%; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">&#160;Ttle</td>
              <td rowspan="1" colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
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              <td rowspan="1" style="width: 46%;">&#160;</td>
              <td rowspan="1" colspan="1" style="width: 1%;">&#160;</td>
              <td rowspan="1" style="width: 26%;">&#160;</td>
              <td rowspan="1" colspan="1" style="width: 1%;">&#160;</td>
              <td rowspan="1" style="width: 26%;">&#160;</td>
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            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000; font-weight: bold;">
                  <div style="color: rgb(0, 0, 0); background-color: rgb(255, 255, 255); font-weight: normal; font-family: 'Times New Roman',Times,serif; font-style: normal; font-variant: normal; text-transform: none;">/s/ Alexander D. Macrae</div>
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              <td style="width: 26%; padding-bottom: 2px;">
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              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
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              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">Alexander D. Macrae, M.B., Ch.B., Ph.D.</div>
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                <div style="color: #000000;">(<font style="font-style: italic;">Principal Executive Officer</font>)</div>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">/s/ Prathyusha Duraibabu</div>
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              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Senior Vice President and Chief Financial Officer</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
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                <div style="text-align: right;">November 12, 2024</div>
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              <td style="width: 46%;">
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              <td colspan="1" style="width: 1%;">&#160;</td>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">/s/ H. Stewart Parker</div>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;">
                <div style="color: #000000;">Director and Chairman of the Board</div>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;">
                <div style="text-align: right;">November 12, 2024</div>
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              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">H. Stewart Parker</div>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
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                  <div style="text-align: center; color: #000000;">/s/ Courtney Beers</div>
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              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
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              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">Courtney Beers, Ph.D.</div>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">/s/ Robert F. Carey</div>
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              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
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            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">Robert F. Carey</div>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
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              <td style="width: 26%;"><br>
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              <td style="width: 46%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
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              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
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              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
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              <td style="width: 46%;">
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              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 46%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 26%;"><br>
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              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
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              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
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            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">James R. Meyers</div>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
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              <td style="width: 46%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 26%;"><br>
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              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
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              <td style="width: 46%;">
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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              <td style="width: 26%;"><br>
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              <td style="width: 46%;"><br>
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              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
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{"company-data": {"conformed-name": "SANGAMO THERAPEUTICS, INC", "cik": "0001001233", "assigned-sic": "2836", "organization-name": "03 Life Sciences", "irs-number": "680359556", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-283180", "film-number": "241450023"}, "business-address": {"street1": "501 CANAL BLVD.", "city": "RICHMOND", "state": "CA", "zip": "94084", "phone": "5109706000"}, "mail-address": {"street1": "501 CANAL BLVD.", "city": "RICHMOND", "state": "CA", "zip": "94084"}, "former-company": {"former-conformed-name": "SANGAMO BIOSCIENCES INC", "date-changed": "20000208"}}
As filed with the Securities and Exchange Commission on November 12, 2024
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
SANGAMO THERAPEUTICS, INC.
(Exact name of registrant as specified in its charter)
Delaware
68-0359556
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
501 Canal Blvd.
Richmond, California
94084
(Address of Principal Executive Offices)
(Zip Code)
Amended and Restated Sangamo Therapeutics, Inc. 2018 Equity Incentive Plan
(Full title of the plan)
Alexander D. Macrae
President and Chief Executive Officer
Sangamo Therapeutics, Inc.
501 Canal Blvd.
Richmond, California 94084
(510) 970-6000
(Name and address of agent for service) (telephone number, including area code, of agent for service)
Copies to:
Scott Willoughby
Senior Vice President and General Counsel
Sangamo Therapeutics, Inc.
501 Canal Blvd.
Richmond, California 94084
(510) 970-6000
Chadwick L. Mills
Courtney M.W. Tygesson
Cooley LLP
3 Embarcadero Center, 20th Floor
San Francisco, CA  94111
(415) 693-2000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
        filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☒
Non-accelerated filer
☐
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
        Securities Act. ☐
EXPLANATORY NOTE
This Registration Statement on Form S-8 is being filed by Sangamo Therapeutics, Inc. (the "Registrant") with the Securities and Exchange Commission (the "Commission") for the purpose of registering an additional 11,000,000 shares of the
        Registrant's common stock, par value $0.01 per share (the "Common Stock"), to be issued pursuant to the Registrant's Amended and Restated 2018 Equity Incentive Plan (the "2018 Plan").  The Registrant previously registered (i) 19,131,725 shares of
        Common Stock that are or may become issuable under the 2018 Plan pursuant to the Registrant's registration statement on
Form S-8
(File No. 333-225552)
        filed with the Commission on June 11, 2018 (the "2018 Form S-8"), (ii) 9,900,000 shares of Common Stock that are or may become issuable under the 2018 Plan pursuant to the Registrant's registration statement on
Form S-8
(File No. 333-241033) filed with the Commission on August 5, 2020 (the "2020 Form S-8"), (iii) 7,900,000 shares of Common Stock that are or may
        become issuable under the 2018 Plan pursuant to the Registrant's registration statement on
Form S-8
(File No. 333-269925) filed with the Commission on
        February 23, 2023 (the "2023 Form S-8"), and (iv) 10,000,000 shares of Common Stock that are or may become issuable under the 2018 Plan pursuant to the Registrant's registration statement on
Form S-8
(File No. 333-273805) filed with the Commission on August 8, 2023 (together with the 2018 Form S-8, the 2020 Form S-8, and the 2023 Form S-8,
        the "Prior Registration Statements"). This
Registration Statement relates to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with General
          Instruction E of Form S-8. Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements are incorporated by reference herein.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference
The following documents filed by the Registrant with the Commission are incorporated by reference into this Registration Statement:
•
the Registrant's annual report on Form 10-K for the year ended December 31, 2023, which was filed with the Commission on
March 13, 2024
;
•
the information specifically incorporated by reference into the Registrant's annual report on Form 10-K for the year ended December 31, 2023 from the Registrant's definitive proxy statement on
Schedule

                14A
, which was filed with the Commission on
April 19, 2024
;
•
the Registrant's quarterly reports on
Form 10-Q
for the quarters ended March 31, 2024, June 30, 2024 and September 30, 2024, which were filed with the Commission on
May 9, 2024
,
August 6,
                  2024
and
November 12, 2024
, respectively
;
•
the Registrant's current reports on Form 8-K, which were filed with the Commission on
January
                  19, 2024
,
February 6, 2024
,
March 25, 2024
,
April 30,
                  2024
,
June 5, 2024
and
July 24, 2024
; and
•
the description of the Common Stock contained in the Registrant's registration statement on
Form
                  8-A
, which was filed with the Commission on March 31, 2000, including all amendments and reports filed for the purpose of updating such description, including
Exhibit 4.1
of the Registrant's annual report on
Form 10-K
for the year ended December 31, 2023.
All reports and other documents filed by the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits
        furnished on such form that relate to such items, after the date of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all
        securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of filing such reports and documents. Any statement contained in a document incorporated or
        deemed to be incorporated herein by reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement herein or in any other subsequently filed document which also is or is deemed to
        be incorporated by reference herein modifies or supersedes that statement. Any such statement so modified or superseded shall not constitute a part of this Registration Statement, except as so modified or superseded.
Item 8.
Exhibits
Exhibit
Number
Description
4.1
Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.3 to the Registrant's Current Report on Form 8-K filed June 2, 2023).
4.2
Certificate of Amendment of the Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K filed June 5, 2024).
4.3
Fifth Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed December 19, 2022).
5.1
Opinion of Cooley LLP.
23.1
Consent of Independent Registered Public Accounting Firm.
23.2
Consent of Cooley LLP is contained in Exhibit 5.1 to this Registration Statement.
24.1
Power of Attorney is contained on the signature page hereto.
99.1
Amended and Restated Sangamo Therapeutics, Inc. 2018 Equity Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed June 5, 2024).
107
Filing fee table.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration
        statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Richmond, State of California, on November 12, 2024.
SANGAMO THERAPEUTICS, INC.
By:
/s/ Alexander D. Macrae
Alexander D. Macrae, M.B., Ch.B., Ph.D.
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Alexander D. Macrae, Prathyusha Duraibabu and Scott Willoughby, and each of them, as his or her true and lawful attorney-in-fact and agent with
        the full power of substitution and resubstitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this registration statement (including post-effective amendments), and to file
        the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing
        requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his or her substitute or
        substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the date indicated.
Signature
Ttle
Date
/s/ Alexander D. Macrae
President, Chief Executive Officer and Director
November 12, 2024
Alexander D. Macrae, M.B., Ch.B., Ph.D.
(
Principal Executive Officer
)
/s/ Prathyusha Duraibabu
Senior Vice President and Chief Financial Officer
November 12, 2024
Prathyusha Duraibabu
(
Principal Financial and Accounting Officer
)
/s/ H. Stewart Parker
Director and Chairman of the Board
November 12, 2024
H. Stewart Parker
/s/ Courtney Beers
Director
November 12, 2024
Courtney Beers, Ph.D.
/s/ Robert F. Carey
Director
November 12, 2024
Robert F. Carey
/s/
Kenneth J. Hillan
Director
November 12, 2024
Kenneth J. Hillan, M.B., Ch.B.
/s/ Margaret A. Horn
Director
November 12, 2024
Margaret A. Horn
/s/ John H. Markels
Director
November 12, 2024
John H. Markels, Ph.D.
/s/ James R. Meyers
Director
November 12, 2024
James R. Meyers
/s/ Karen L. Smith
Director
November 12, 2024
Karen L. Smith, M.D., Ph.D., M.B.A., L.L.M.