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      <div style="text-align: right; font-weight: bold;">As filed with the Securities and Exchange Commission on May 31, 2022</div>
      <div style="text-align: right; font-weight: bold;">Registration No. 333</div>
      <div style="text-align: right; font-weight: bold;"> <br>
      </div>
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      <br>
      <div style="text-align: center; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div style="text-align: center; font-size: 12pt; font-weight: bold;"> <br>
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      <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div style="text-align: center; font-style: italic; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">
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      <br>
      <div style="text-align: center; font-size: 24pt; font-weight: bold;">HELIUS MEDICAL TECHNOLOGIES, INC.</div>
      <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
      <div style="text-align: center; font-weight: bold;"> <br>
      </div>
    </div>
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              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"> Delaware</div>
            </td>
            <td style="width: 2%; vertical-align: middle;">&#160;</td>
            <td style="width: 49%; vertical-align: middle;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">36-4787690</div>
            </td>
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            <td style="width: 49%; vertical-align: middle;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or other jurisdiction of incorporation or organization)</div>
            </td>
            <td style="width: 2%; vertical-align: middle;">&#160;</td>
            <td style="width: 49%; vertical-align: middle;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer Identification Number.)</div>
            </td>
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      <div><br>
      </div>
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              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">642 Newtown Yardley Road, Suite 100</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Newtown, Pennsylvania</div>
            </td>
            <td style="width: 2%; vertical-align: middle;">&#160;</td>
            <td style="width: 49%; vertical-align: middle;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">18940</div>
            </td>
          </tr>
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            <td style="width: 49%; vertical-align: middle;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Address of principal executive offices)</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: middle;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Zip code)</div>
            </td>
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      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Helius Medical Technologies, Inc. 2022 Equity Incentive Plan</div>
      <div style="text-align: center; font-weight: bold;">(Full title of the plan)</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Dane C. Andreeff</div>
      <div style="text-align: center; font-weight: bold;">President and Chief Executive Officer</div>
      <div style="text-align: center; font-weight: bold;">Helius Medical Technologies, Inc.</div>
      <div style="text-align: center; font-weight: bold;">642 Newtown Yardley Road, Suite 100</div>
      <div style="text-align: center; font-weight: bold;">Newtown, Pennsylvania 18940</div>
      <div style="text-align: center; font-weight: bold;">(215) 944-6100</div>
      <div style="text-align: center; font-weight: bold;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
      <div><br>
      </div>
      <div style="text-align: center;">
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      <div><br>
      </div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">Copy to:</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Phillip D. Torrence, Esq.</div>
      <div style="text-align: center; font-weight: bold;">Emily J. Johns, Esq.</div>
      <div style="text-align: center; font-weight: bold;">Honigman LLP</div>
      <div style="text-align: center; font-weight: bold;">650 Trade Center Way, Suite 200</div>
      <div style="text-align: center; font-weight: bold;">Kalamazoo, Michigan 49002-0402</div>
      <div style="text-align: center; font-weight: bold;">(269) 337-7700</div>
      <div><br>
      </div>
      <div style="text-align: center;">
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      </div>
      <div style="text-align: justify;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large
        accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
      <div>&#160;</div>
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              <div><font style="color: rgb(0, 0, 0);">Large accelerated filer</font></div>
            </td>
            <td style="width: 4.55%; vertical-align: bottom;">
              <div style="text-align: justify; color: rgb(0, 0, 0);">&#9744;</div>
            </td>
            <td style="width: 45%; vertical-align: top;">
              <div style="text-align: right; color: rgb(0, 0, 0);">Accelerated filer</div>
            </td>
            <td style="width: 4.55%; vertical-align: bottom;">
              <div style="text-align: right; color: rgb(0, 0, 0);">&#9744;</div>
            </td>
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            <td style="width: 45%; vertical-align: top;">&#160;</td>
            <td style="width: 4.55%; vertical-align: middle;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">&#160;</td>
            <td style="width: 4.55%; vertical-align: middle; text-align: right;">&#160;</td>
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            <td style="width: 45%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
            </td>
            <td style="width: 4.55%; vertical-align: bottom;">&#9746;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="text-align: right; color: rgb(0, 0, 0);">Smaller reporting company</div>
            </td>
            <td style="width: 4.55%; vertical-align: bottom; text-align: right;">&#9746;</td>
          </tr>
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            <td style="width: 45%; vertical-align: middle;">&#160;</td>
            <td style="width: 4.55%; vertical-align: middle;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">&#160;</td>
            <td style="width: 4.55%; vertical-align: middle; text-align: right;">&#160;</td>
          </tr>
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            <td style="width: 45%; vertical-align: bottom;">&#160;</td>
            <td style="width: 4.55%; vertical-align: bottom;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="text-align: right; color: rgb(0, 0, 0);">Emerging growth company</div>
            </td>
            <td style="width: 4.55%; vertical-align: bottom; text-align: right;">&#9744;</td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
        Section 7(a)(2)(B) of the Securities Act.&#160; &#9744;</div>
      <div>&#160;</div>
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      <div style="text-align: center; font-weight: bold;">PART I</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN PROSPECTUS</div>
      <div>&#160;</div>
      <div style="text-align: justify;">The information specified in Part I of Form S-8 is omitted from this Registration Statement in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the <font style="font-weight: bold; font-style: italic;">&#8220;Securities Act&#8221;</font>) and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I of Form S-8 will be delivered to the participants in the plan covered by this
        Registration Statement as specified by Rule 428(b)(1) under the Securities Act.</div>
      <div>&#160;</div>
      <div style="text-align: center; font-weight: bold;">PART II</div>
      <div>&#160;</div>
      <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
      <div>&#160;</div>
      <div>
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                <div style="text-align: justify;"><font style="font-weight: bold;">Item 3.</font></div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Incorporation of Documents by Reference</font>.</div>
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      <div>&#160;</div>
      <div style="text-align: justify;">The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z8f2887abd17e4bae80831c357fab7cbe" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 36pt; vertical-align: top;">(a)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>the Registrant&#8217;s Annual Report on Form 10-K for the year ended December&#160; 31, 2021 filed with the Securities and Exchange Commission (the &#8220;<font style="font-weight: bold; font-style: italic;">Commission</font>&#8221;) on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1610853/000156459022010124/hsdt-10k_20211231.htm#ITEM_15_EXHIBITS_FINANCIAL_STATEMENT_SCH"><u>March 14, 2022</u></a> (including information specifically incorporated by reference
                therein from the Registrant&#8217;s Proxy Statement filed with the Commission on <a href="https://www.sec.gov/Archives/edgar/data/1610853/000114036122015563/ny20002715x2_def14a.htm"><u>April 22, 2022</u></a>);</div>
            </td>
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      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z5d5ef8e589f144e0928f81155e335627" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(b)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div><font style="color: rgb(0, 0, 0);">the Registrant&#8217;s Quarterly Report on Form 10-Q for the quarter ended March 31, 2022 filed with the Commission on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1610853/000156459022019681/hsdt-10q_20220331.htm"><u>May 12, 2022</u></a><font style="color: rgb(0, 0, 0);">;</font></div>
            </td>
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      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z9727f7d8a16e4f018ad84d276e738bba" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(c)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div><font style="color: rgb(0, 0, 0);">the Registrant&#8217;s Current Reports on Form 8-K filed with the Commission on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1610853/000156459022005702/hsdt-8k_20220216.htm"><u>February
                    18, 2022</u></a><font style="color: rgb(0, 0, 0);">, </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1610853/000156459022009857/hsdt-8k_20220308.htm"><u>March 11, 2022</u></a><font style="color: rgb(0, 0, 0);">, and </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1610853/000114036122016092/brhc10036674_8k.htm"><u>April 27, 2022</u></a><font style="color: rgb(0, 0, 0);">; and</font></div>
            </td>
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      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zfb2ac504c5d0425ea8162239a8e16413" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 36pt; vertical-align: top;">(d)</td>
            <td style="width: auto; vertical-align: top; text-align: justify; color: rgb(0, 0, 0);">
              <div>the description of the Registrant&#8217;s Common Stock contained in the Registrant&#8217;s Form 8-A (File No. 001-38445) filed with the Commission on <a href="https://www.sec.gov/Archives/edgar/data/0001610853/000119312518106706/d560270d8a12b.htm"><u>April&#160;





                    4, 2018</u></a>, as amended by the description of the Common Stock contained in Exhibit 4.7 to the Registrant&#8217;s Annual Report on Form 10-K for the year ended December 31, 2020, and as further amended by any subsequent amendment or
                report filed for the purpose of updating such description.</div>
            </td>
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      </table>
      <div>&#160;</div>
      <div style="text-align: justify;">In addition, all documents the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the <font style="font-weight: bold; font-style: italic;">&#8220;Exchange Act&#8221;</font>), after the filing of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities covered
        hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part hereof from the date of filing of such documents. Notwithstanding anything herein, the Registrant is not incorporating by reference any
        information furnished under Item 2.02 or Item 7.01 of any Current Report on Form 8-K, unless, and to the extent, specified in any such Current Report on Form 8-K.</div>
      <div>&#160;</div>
      <div style="text-align: justify;">Any statement herein or contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent
        that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated by reference herein, modifies or supersedes such prior statement. Any such statement so modified or superseded shall not be
        deemed, except as so modified or superseded, to constitute part of this Registration Statement.</div>
      <div>&#160;</div>
      <div>
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                <div style="text-align: justify;"><font style="font-weight: bold;">Item 4.</font></div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Description of Securities</font>.</div>
              </td>
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      </div>
      <div>&#160;</div>
      <div style="text-align: justify;">Not applicable.</div>
      <div>&#160;</div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">2</font></div>
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              <td style="vertical-align: top; width: 36pt;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Item 5.</font></div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="text-align: justify;">I<font style="font-weight: bold;">nterests of Named Experts and Counsel.</font></div>
              </td>
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      </div>
      <div>&#160;</div>
      <div style="text-align: justify;">Not applicable.</div>
      <div>&#160;</div>
      <div>
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              <td style="vertical-align: top; width: 36pt;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Item 6.</font></div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Indemnification of Directors and Officers</font>.</div>
              </td>
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      </div>
      <div>&#160;</div>
      <div style="text-align: justify;">We are incorporated under the laws of the State of Delaware. Section 102 of the Delaware General Corporation Law permits a corporation to eliminate the personal liability of directors of a corporation to the
        corporation or its stockholders for monetary damages for a breach of fiduciary duty as a director, except where the director breached his or her duty of loyalty, failed to act in good faith, engaged in intentional misconduct or knowingly violated a
        law, authorized the payment of a dividend or approved a stock repurchase in violation of Delaware corporate law or obtained an improper personal benefit.</div>
      <div>&#160;</div>
      <div style="text-align: justify;">Section 145 of the Delaware General Corporation Law provides that a corporation has the power to indemnify a director, officer, employee or agent of the corporation and certain other persons serving at the request of
        the corporation in related capacities against expenses (including attorneys&#8217; fees), judgments, fines and amounts paid in settlements actually and reasonably incurred by the person in connection with an action, suit or proceeding to which he or she
        is or is threatened to be made a party by reason of such position, if such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the corporation, and, in any criminal action or
        proceeding, had no reasonable cause to believe his or her conduct was unlawful, except that, in the case of actions brought by or in the right of the corporation, no indemnification shall be made with respect to any claim, issue or matter as to
        which such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability but in view of all of the
        circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper.</div>
      <div>&#160;</div>
      <div style="text-align: justify;">As permitted by the Delaware General Corporation Law, our amended and restated bylaws provide that: (1) we are required to indemnify our directors and executive officers to the fullest extent permitted by the
        Delaware General Corporation Law; (2) we may, in our discretion, indemnify our other officers, employees and agents as set forth in the Delaware General Corporation Law; (3) we are required, upon satisfaction of certain conditions, to advance all
        expenses incurred by our directors and executive officers in connection with certain legal proceedings; (4) the rights conferred in the bylaws are not exclusive; (5) we are authorized to enter into indemnification agreements with our directors,
        officers, employees and agents; and (6) we may secure insurance on behalf of any director, officer, employee or other agent for any liability arising out of his or her actions in that capacity regardless of whether we would otherwise be permitted
        to indemnify him or her under the provisions of Delaware law.</div>
      <div>&#160;</div>
      <div style="text-align: justify; font-style: italic;">Indemnification Agreements</div>
      <div>&#160;</div>
      <div style="text-align: justify;">We have entered into indemnification agreements with our directors and officers. These agreements provide broader indemnity rights than those provided under the Delaware General Corporation Law and the Registrant&#8217;s
        certificate of incorporation, as amended. The indemnification agreements are not intended to deny or otherwise limit third-party or derivative suits against us or our directors or officers, but to the extent a director or officer were entitled to
        indemnity or contribution under the indemnification agreement, the financial burden of a third-party suit would be borne by us, and we would not benefit from derivative recoveries against the director or officer. Such recoveries would accrue to our
        benefit but would be offset by our obligations to the director or officer under the indemnification agreement.</div>
      <div>&#160;</div>
      <div style="text-align: justify; font-style: italic;">Insurance Policy</div>
      <div>&#160;</div>
      <div style="text-align: justify;">We maintain a directors&#8217; and officers&#8217; liability insurance policy. The policy insures directors and officers against unindemnified losses arising from certain wrongful acts in their capacities as directors and
        officers and reimburses us for those losses for which we have lawfully indemnified the directors and officers. The policy contains various exclusions.</div>
      <div>&#160;</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">3</font></div>
        <div id="DSPFPageBreak" style="page-break-after:always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: justify;">The foregoing summaries are not intended to be exhaustive and are qualified in their entirety by reference to the complete text of the statute, the Registrant&#8217;s certificate of incorporation, as amended and the
        agreements referred to above and are qualified in their entirety by reference thereto.</div>
      <div>&#160;</div>
      <div>
        <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z31efc800426d4cb8a1fdfd5d78a06a7d" class="DSPFListTable">

            <tr style="vertical-align: top;">
              <td style="vertical-align: top; width: 36pt;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Item 7.</font></div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Exemption from Registration Claimed</font>.</div>
              </td>
            </tr>

        </table>
      </div>
      <div>&#160;</div>
      <div style="text-align: justify;">Not applicable.</div>
      <div>&#160;</div>
      <div>
        <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z69767816fdfa4367bc28038e182fe2a8" class="DSPFListTable">

            <tr style="vertical-align: top;">
              <td style="vertical-align: top; width: 36pt;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Item 8.</font></div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Exhibits</font>.</div>
              </td>
            </tr>

        </table>
      </div>
      <div>&#160;</div>
      <div style="text-align: center; font-weight: bold;">EXHIBIT INDEX</div>
      <div>&#160;</div>
      <div style="text-align: justify;">The following exhibits are filed as part of this registration statement.</div>
      <div>&#160;</div>
      <div style="text-align: center; font-weight: bold;">INDEX TO EXHIBITS</div>
      <div>&#160;</div>
      <div>
        <table cellspacing="0" cellpadding="0" border="0" id="z4df899ed030a44f1a3897e8896f1f42a" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibit<br>
                  Number</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="color: rgb(0, 0, 0); font-weight: bold;">Description</div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: middle;">&#160;</td>
              <td style="width: 1%; vertical-align: middle;">&#160;</td>
              <td style="width: 93%; vertical-align: middle;">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">4.1</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: top;">
                <div style="text-align: justify;"><font style="color: rgb(0, 0, 0);">Certificate of Conversion filed with the Delaware Secretary of State on July&#160; 18, 2018 (</font><a href="https://www.sec.gov/Archives/edgar/data/1610853/000156459018020736/hsdt-ex31_66.htm">incorporated by reference to Exhibit 3.1 to the Form 10-Q filed August&#160;9, 2018</a><font style="color: rgb(0, 0, 0);">)</font></div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: middle;">&#160;</td>
              <td style="width: 1%; vertical-align: middle;">&#160;</td>
              <td style="width: 93%; vertical-align: middle;">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">4.2</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: top;">
                <div style="text-align: justify;"><font style="color: rgb(0, 0, 0);">Certificate of Incorporation, as corrected (</font><a href="https://www.sec.gov/Archives/edgar/data/1610853/000119312518312155/d646047dex31.htm">incorporated by reference
                    to Exhibit 3.1 to the Form 8-K filed October&#160;30, 2018</a><font style="color: rgb(0, 0, 0);">)</font></div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: middle;">&#160;</td>
              <td style="width: 1%; vertical-align: middle;">&#160;</td>
              <td style="width: 93%; vertical-align: middle;">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">4.3</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: top;">
                <div style="text-align: justify;"><font style="color: rgb(0, 0, 0);">Certificate of Amendment to Certificate of Incorporation (</font><a href="https://www.sec.gov/Archives/edgar/data/1610853/000156459020058917/hsdt-ex31_7.htm">incorporated
                    by reference to Exhibit 3.1 to the Form 8-K filed on December&#160;31, 2020</a><font style="color: rgb(0, 0, 0);">)</font></div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: middle;">&#160;</td>
              <td style="width: 1%; vertical-align: middle;">&#160;</td>
              <td style="width: 93%; vertical-align: middle;">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">4.4</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: top;">
                <div style="text-align: justify;"><font style="color: rgb(0, 0, 0);">Bylaws as amended and restated (</font><a href="https://www.sec.gov/Archives/edgar/data/1610853/000156459018020736/hsdt-ex33_68.htm">incorporated by reference to Exhibit
                    3.3 to the Form 10-Q filed August &#160;9, 2018</a><font style="color: rgb(0, 0, 0);">)</font></div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: middle;">&#160;</td>
              <td style="width: 1%; vertical-align: middle;">&#160;</td>
              <td style="width: 93%; vertical-align: middle;">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">4.5&#8224;</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: top;">
                <div style="text-align: justify;">Helius Medical Technologies, Inc. 2022 Equity Incentive Plan (<a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001610853/000156459022005702/hsdt-8k_20220216.htm">incorporated by reference to
                    Exhibit 10.1 to the Form 8-K filed on February 18, 2022</a>)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: middle;">&#160;</td>
              <td style="width: 1%; vertical-align: middle;">&#160;</td>
              <td style="width: 93%; vertical-align: middle;">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">4.6&#8224;</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify;">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: top;">
                <div style="text-align: justify;">Helius Medical Technologies, Inc. 2022 Equity Incentive Plan Form of Option Agreement (<a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001610853/000156459022005702/hsdt-8k_20220216.htm">incorporated





                    by reference to Exhibit 10.3 to the Form 8-K filed on February 18, 2022</a>)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: middle;">&#160;</td>
              <td style="width: 1%; vertical-align: middle;">&#160;</td>
              <td style="width: 93%; vertical-align: middle;">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">5.1</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: top;">
                <div><a href="brhc10038242_ex5-1.htm">Opinion of Honigman LLP</a></div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: middle;">&#160;</td>
              <td style="width: 1%; vertical-align: middle;">&#160;</td>
              <td style="width: 93%; vertical-align: middle;">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">23.1</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: top;">
                <div><a href="brhc10038242_ex23-1.htm">Consent of BDO USA, LLP</a></div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: middle;">&#160;</td>
              <td style="width: 1%; vertical-align: middle;">&#160;</td>
              <td style="width: 93%; vertical-align: middle;">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">23.2</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: top;">
                <div><a href="brhc10038242_ex5-1.htm">Consent of Honigman LLP (included in its opinion filed as Exhibit 5.1 to this Registration Statement)</a></div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: middle;">&#160;</td>
              <td style="width: 1%; vertical-align: middle;">&#160;</td>
              <td style="width: 93%; vertical-align: middle;">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">24.1</div>
              </td>
              <td style="width: 1%; vertical-align: bottom;">
                <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;&#160;</div>
              </td>
              <td style="width: 93%; vertical-align: top;">
                <div><a href="#POWEROFATTORNE">Power of Attorney (included after the signature of the Registrant contained on Signature Page of this Registration Statement)</a></div>
              </td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;" rowspan="1">&#160;</td>
              <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
              <td style="width: 93%; vertical-align: top;" rowspan="1">&#160;</td>
            </tr>
            <tr>
              <td nowrap="nowrap" style="width: 6%; vertical-align: top;" rowspan="1">107<br>
              </td>
              <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
              <td style="width: 93%; vertical-align: top;" rowspan="1"><a href="brhc10038242_ex107.htm">Filing Fee Table<br>
                </a></td>
            </tr>

        </table>
      </div>
      <div style="text-align: justify;"> <br>
      </div>
      <div style="text-align: justify;">&#8224;-Indicates management compensatory plan, contract or arrangement.</div>
      <div>&#160;</div>
      <div>
        <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z51d5277b41994856b80b1c070db3bcc3" class="DSPFListTable">

            <tr style="vertical-align: top;">
              <td style="vertical-align: top; width: 36pt;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Item 9.</font></div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="text-align: justify;"><font style="font-weight: bold;">Undertakings.</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z36ebac43ab7641b8bdcabaf2d7c05c99" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top;">(a)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>The Registrant hereby undertakes:</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z028c2d14cc1548ab8e58f12f20dfb162" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 72pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top;">(1)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zd25388edf83a47f489f70a636c6c36ff" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 108pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top;">(i)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>To include any prospectus required by Section 10(a)(3) of the Securities Act;</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">4</font></div>
        <div id="DSPFPageBreak" style="page-break-after:always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <table cellspacing="0" cellpadding="0" id="z8b5a39d7cb5c4e468641ea19d3e8f05d" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 108pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top;">(ii)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change
                in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered)
                and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent
                no more than a 20 percent change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective Registration Statement;</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z47143dd9c13d43ca837e27705fa2e213" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 108pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top;">(iii)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement;</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div style="text-align: justify;"><font style="font-style: italic;">provided, however, </font>that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is
        contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement; and</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zd6b0ee8f826c41a0b25cb46d77e92553" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 72pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div><font style="color: rgb(0, 0, 0);">That, for the purpose of </font>determining<font style="color: rgb(0, 0, 0);"> any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
                  statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</font></div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="za85ac2507e8240dcbf125e8ed838bfbd" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 72pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="color: rgb(0, 0, 0);">To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z4820be2180554c12b6020a857ca7f26f" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top;">(b)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>The Registrant hereby undertakes that, for the purposes of determining any liability under the Securities Act, each filing of the Registrant&#8217;s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where
                applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating
                to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zb87c686ea73e49d79f42937f9ffca2db" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top;">(c)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been
                advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other
                than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling
                person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether
                such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">5</font></div>
        <div id="DSPFPageBreak" style="page-break-after:always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
      <div>&#160;</div>
      <div style="text-align: justify;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
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      <div style="text-align: justify;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Dane C. Andreeff and Jeffrey Mathiesen as his or her true and lawful attorneys-in-fact and agents
        with full power of substitution, severally, for him in any and all capacities, to sign the Registration Statement on Form S-8 of Helius Medical Technologies, Inc., and any or all amendments (including post-effective amendments thereto), and to file
        the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every act and thing
        requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or their substitute or
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      <div style="text-align: justify;">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.</div>
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{"company-data": {"conformed-name": "HELIUS MEDICAL TECHNOLOGIES, INC.", "cik": "0001610853", "assigned-sic": "3845", "irs-number": "364787690", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-265324", "film-number": "22984346"}, "business-address": {"street1": "642 NEWTOWN YARDLEY ROAD", "city": "NEWTOWN", "state": "PA", "zip": "18940", "phone": "215-944-6104"}, "mail-address": {"street1": "642 NEWTOWN YARDLEY ROAD", "city": "NEWTOWN", "state": "PA", "zip": "18940"}, "former-company": [{"former-conformed-name": "HELIUS MEDICAL TECHNOLOGIES, INC", "date-changed": "20180517"}, {"former-conformed-name": "HELIUS MEDICAL TECHNOLOGIES, INC.", "date-changed": "20140613"}]}
As filed with the Securities and Exchange Commission on May 31, 2022
Registration No. 333
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
HELIUS MEDICAL TECHNOLOGIES, INC.
(Exact name of registrant as specified in its charter)
Delaware
36-4787690
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification Number.)
642 Newtown Yardley Road, Suite 100
Newtown, Pennsylvania
18940
(Address of principal executive offices)
(Zip code)
Helius Medical Technologies, Inc. 2022 Equity Incentive Plan
(Full title of the plan)
Dane C. Andreeff
President and Chief Executive Officer
Helius Medical Technologies, Inc.
642 Newtown Yardley Road, Suite 100
Newtown, Pennsylvania 18940
(215) 944-6100
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copy to:
Phillip D. Torrence, Esq.
Emily J. Johns, Esq.
Honigman LLP
650 Trade Center Way, Suite 200
Kalamazoo, Michigan 49002-0402
(269) 337-7700
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large
        accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
        Section 7(a)(2)(B) of the Securities Act.  ☐
PART I
INFORMATION REQUIRED IN PROSPECTUS
The information specified in Part I of Form S-8 is omitted from this Registration Statement in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the
"Securities Act"
) and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I of Form S-8 will be delivered to the participants in the plan covered by this
        Registration Statement as specified by Rule 428(b)(1) under the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference
.
The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:
(a)
the Registrant's Annual Report on Form 10-K for the year ended December  31, 2021 filed with the Securities and Exchange Commission (the "
Commission
") on
March 14, 2022
(including information specifically incorporated by reference
                therein from the Registrant's Proxy Statement filed with the Commission on
April 22, 2022
);
(b)
the Registrant's Quarterly Report on Form 10-Q for the quarter ended March 31, 2022 filed with the Commission on
May 12, 2022
;
(c)
the Registrant's Current Reports on Form 8-K filed with the Commission on
February
                    18, 2022
,
March 11, 2022
, and
April 27, 2022
; and
(d)
the description of the Registrant's Common Stock contained in the Registrant's Form 8-A (File No. 001-38445) filed with the Commission on
April 

                    4, 2018
, as amended by the description of the Common Stock contained in Exhibit 4.7 to the Registrant's Annual Report on Form 10-K for the year ended December 31, 2020, and as further amended by any subsequent amendment or
                report filed for the purpose of updating such description.
In addition, all documents the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the
"Exchange Act"
), after the filing of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities covered
        hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part hereof from the date of filing of such documents. Notwithstanding anything herein, the Registrant is not incorporating by reference any
        information furnished under Item 2.02 or Item 7.01 of any Current Report on Form 8-K, unless, and to the extent, specified in any such Current Report on Form 8-K.
Any statement herein or contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent
        that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated by reference herein, modifies or supersedes such prior statement. Any such statement so modified or superseded shall not be
        deemed, except as so modified or superseded, to constitute part of this Registration Statement.
Item 4.
Description of Securities
.
Not applicable.
2
Item 5.
I
nterests of Named Experts and Counsel.
Not applicable.
Item 6.
Indemnification of Directors and Officers
.
We are incorporated under the laws of the State of Delaware. Section 102 of the Delaware General Corporation Law permits a corporation to eliminate the personal liability of directors of a corporation to the
        corporation or its stockholders for monetary damages for a breach of fiduciary duty as a director, except where the director breached his or her duty of loyalty, failed to act in good faith, engaged in intentional misconduct or knowingly violated a
        law, authorized the payment of a dividend or approved a stock repurchase in violation of Delaware corporate law or obtained an improper personal benefit.
Section 145 of the Delaware General Corporation Law provides that a corporation has the power to indemnify a director, officer, employee or agent of the corporation and certain other persons serving at the request of
        the corporation in related capacities against expenses (including attorneys' fees), judgments, fines and amounts paid in settlements actually and reasonably incurred by the person in connection with an action, suit or proceeding to which he or she
        is or is threatened to be made a party by reason of such position, if such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the corporation, and, in any criminal action or
        proceeding, had no reasonable cause to believe his or her conduct was unlawful, except that, in the case of actions brought by or in the right of the corporation, no indemnification shall be made with respect to any claim, issue or matter as to
        which such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability but in view of all of the
        circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper.
As permitted by the Delaware General Corporation Law, our amended and restated bylaws provide that: (1) we are required to indemnify our directors and executive officers to the fullest extent permitted by the
        Delaware General Corporation Law; (2) we may, in our discretion, indemnify our other officers, employees and agents as set forth in the Delaware General Corporation Law; (3) we are required, upon satisfaction of certain conditions, to advance all
        expenses incurred by our directors and executive officers in connection with certain legal proceedings; (4) the rights conferred in the bylaws are not exclusive; (5) we are authorized to enter into indemnification agreements with our directors,
        officers, employees and agents; and (6) we may secure insurance on behalf of any director, officer, employee or other agent for any liability arising out of his or her actions in that capacity regardless of whether we would otherwise be permitted
        to indemnify him or her under the provisions of Delaware law.
Indemnification Agreements
We have entered into indemnification agreements with our directors and officers. These agreements provide broader indemnity rights than those provided under the Delaware General Corporation Law and the Registrant's
        certificate of incorporation, as amended. The indemnification agreements are not intended to deny or otherwise limit third-party or derivative suits against us or our directors or officers, but to the extent a director or officer were entitled to
        indemnity or contribution under the indemnification agreement, the financial burden of a third-party suit would be borne by us, and we would not benefit from derivative recoveries against the director or officer. Such recoveries would accrue to our
        benefit but would be offset by our obligations to the director or officer under the indemnification agreement.
Insurance Policy
We maintain a directors' and officers' liability insurance policy. The policy insures directors and officers against unindemnified losses arising from certain wrongful acts in their capacities as directors and
        officers and reimburses us for those losses for which we have lawfully indemnified the directors and officers. The policy contains various exclusions.
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The foregoing summaries are not intended to be exhaustive and are qualified in their entirety by reference to the complete text of the statute, the Registrant's certificate of incorporation, as amended and the
        agreements referred to above and are qualified in their entirety by reference thereto.
Item 7.
Exemption from Registration Claimed
.
Not applicable.
Item 8.
Exhibits
.
EXHIBIT INDEX
The following exhibits are filed as part of this registration statement.
INDEX TO EXHIBITS
Exhibit
Number
Description
4.1
Certificate of Conversion filed with the Delaware Secretary of State on July  18, 2018 (
incorporated by reference to Exhibit 3.1 to the Form 10-Q filed August 9, 2018
)
4.2
Certificate of Incorporation, as corrected (
incorporated by reference
                    to Exhibit 3.1 to the Form 8-K filed October 30, 2018
)
4.3
Certificate of Amendment to Certificate of Incorporation (
incorporated
                    by reference to Exhibit 3.1 to the Form 8-K filed on December 31, 2020
)
4.4
Bylaws as amended and restated (
incorporated by reference to Exhibit
                    3.3 to the Form 10-Q filed August  9, 2018
)
4.5†
Helius Medical Technologies, Inc. 2022 Equity Incentive Plan (
incorporated by reference to
                    Exhibit 10.1 to the Form 8-K filed on February 18, 2022
)
4.6†
Helius Medical Technologies, Inc. 2022 Equity Incentive Plan Form of Option Agreement (
incorporated

                    by reference to Exhibit 10.3 to the Form 8-K filed on February 18, 2022
)
5.1
Opinion of Honigman LLP
23.1
Consent of BDO USA, LLP
23.2
Consent of Honigman LLP (included in its opinion filed as Exhibit 5.1 to this Registration Statement)
24.1
Power of Attorney (included after the signature of the Registrant contained on Signature Page of this Registration Statement)
107
Filing Fee Table
†-Indicates management compensatory plan, contract or arrangement.
Item 9.
Undertakings.
(a)
The Registrant hereby undertakes:
(1)
To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)
To include any prospectus required by Section 10(a)(3) of the Securities Act;
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(ii)
To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change
                in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered)
                and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent
                no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective Registration Statement;
(iii)
To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement;
provided, however,
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is
        contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement; and
(2)
That, for the purpose of
determining
any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration
                  statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(3)
To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)
The Registrant hereby undertakes that, for the purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where
                applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating
                to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been
                advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other
                than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling
                person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether
                such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
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SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
        Registration Statement to be signed on its behalf by the undersigned, hereunto duly authorized, in City of Newtown, State of Pennsylvania, on May 31, 2022.
Helius Medical Technologies, Inc.
By:
/s/ Dane C. Andreeff
Name:
Dane C. Andreeff
Title:
President and Chief Executive Officer
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POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Dane C. Andreeff and Jeffrey Mathiesen as his or her true and lawful attorneys-in-fact and agents
        with full power of substitution, severally, for him in any and all capacities, to sign the Registration Statement on Form S-8 of Helius Medical Technologies, Inc., and any or all amendments (including post-effective amendments thereto), and to file
        the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every act and thing
        requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or their substitute or
        substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.
Signature
Title
Date
/s/
Dane C. Andreeff
President, Chief Executive Officer
May 31, 2022
Dane C. Andreeff
(Principal Executive Officer) and Director
/s/
Jeffrey S. Mathiesen
Chief Financial Officer
May 31, 2022
Jeffrey S. Mathiesen
(Principal Financial Officer and Principal Accounting Officer), Treasurer, Secretary and Director
/s/
Paul Buckman
Director
May 31, 2022
Paul Buckman
/s/
Blane Walter
Director
May 31, 2022
Blane Walter
/s/
Sherrie Perkins
Director
May 31, 2022
Sherrie Perkins
/s/
Edward M. Straw
Director
May 31, 2022
Edward M. Straw
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