<html>
  <head>
    <title></title>
    <!-- Licensed to: Summit, a Broadridge Company
         Document created using EDGARfilings PROfile 6.2.2.0
         Copyright 1995 - 2019 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <div>
      <div style="text-align: center;">As filed with the Securities and Exchange Commission on August 8, 2019</div>
      <div style="text-align: right;">Registration No. 333-</div>
    </div>
  </div>
  <div>
    <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;">
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">WASHINGTON, D.C. 20549</div>
    <div>&#160;</div>
    <div>
      <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 15%; color: #000000; text-align: center;"></div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div>&#160;</div>
    <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 15%; color: #000000; text-align: center;">
    <div><br>
    </div>
    <div style="text-align: center; font-size: 24pt; font-variant: small-caps; font-weight: bold;">CHF Solutions, Inc.</div>
    <div style="text-align: center; margin-left: 1.8pt;">(Exact name of registrant as specified in its charter)</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="zbbd35d14166d4b59bac095e57349d731" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 49%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Delaware</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">68-0533453</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">(State or other jurisdiction of incorporation or organization)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">(I.R.S. Employer Identification No.)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z79948d50f5254f9cbae194f79442f3a1" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 49%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">12988 Valley View Road</div>
            <div style="text-align: center; font-weight: bold;">Eden Prairie, Minnesota</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>&#160;</div>
            <div style="text-align: center; font-weight: bold;">55344</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">(Address of Principal Executive Offices)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">(Zip Code)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z08aa7d755d3d49e793c970e78cc34ca9" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 99.88%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">CHF Solutions, Inc. 2017 Equity Incentive Plan</div>
            <div style="text-align: center; font-weight: bold;">CHF Solutions, Inc. 2013 Non-Employee Directors&#8217; Equity Incentive Plan</div>
            <div style="text-align: center; font-weight: bold;">CHF Solutions, Inc. New-Hire Equity Incentive Plan</div>
            <div style="text-align: center; font-weight: bold;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 27.17%; vertical-align: top;" rowspan="1">
            <div style="text-align: center;">(Full title of the plan)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="zc66ddb1ee85547d7a27b77b7b2d4e708" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">John L. Erb</div>
            <div style="text-align: center; font-weight: bold;">Chief Executive Officer</div>
            <div style="text-align: center; font-weight: bold;">CHF Solutions, Inc.</div>
            <div style="text-align: center; font-weight: bold;">12988 Valley View Road</div>
            <div style="text-align: center; font-weight: bold;">Eden Prairie, MN 55344</div>
            <div style="text-align: center; font-weight: bold;">(952) 345-4200</div>
          </td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">(Name, address and telephone number, including area code, of agent for service)</div>
          </td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z0290a09f0dc8452b9a15b8d9c8d7ff56" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;" colspan="2">
            <div style="text-align: center; font-weight: bold;">Copies to:</div>
          </td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Phillip D. Torrence, Esq.</div>
            <div style="text-align: center; font-weight: bold;">Meredith Ervine, Esq.</div>
            <div style="text-align: center; font-weight: bold;">Honigman LLP</div>
            <div style="text-align: center;">650 Trade Center Way, Ste 200</div>
            <div style="text-align: center;">Kalamazoo, MI 49002</div>
            <div style="text-align: center;">(269) 337-7700</div>
          </td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Thomas P. Lynch</div>
            <div style="text-align: center; font-weight: bold;">General Counsel</div>
            <div style="text-align: center; font-weight: bold;">CHF Solutions, Inc.</div>
            <div style="text-align: center;">12988 Valley View Road</div>
            <div style="text-align: center;">Eden Prairie, MN 55344</div>
            <div style="text-align: center;">(952) 345-4200</div>
          </td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
      filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div>&#160;</div>
    <div style="text-align: center;">Large accelerated filer &#9744; &#160; &#160; Accelerated filer&#160; &#9744;</div>
    <div>&#160;</div>
    <div style="text-align: center;">Non-accelerated filer &#9746; &#160; &#160;&#160; Smaller reporting company&#160; &#9746;</div>
    <div style="text-align: center;">Emerging growth company &#9744;</div>
    <div> <br>
    </div>
    <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. &#9744;</div>
    <div> <br>
    </div>
    <div>
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;" id="z80434244d8064d90815f2c2f8cf46c6d">

        <tr>
          <td valign="bottom" style="vertical-align: bottom; border-top: 4px double rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">
            <div style="font-weight: bold;">Title of securities to be registered</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-weight: bold;">Amount to be</div>
            <div style="text-align: center; font-weight: bold;"> Registered (1)</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-weight: bold;">Proposed maximum</div>
            <div style="text-align: center; font-weight: bold;"> offering price</div>
            <div style="text-align: center; font-weight: bold;"> per share (2)</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-weight: bold;">Proposed maximum</div>
            <div style="text-align: center; font-weight: bold;"> aggregate offering</div>
            <div style="text-align: center; font-weight: bold;"> price (2)</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-weight: bold;">Amount of</div>
            <div style="text-align: center; font-weight: bold;"> registration</div>
            <div style="text-align: center; font-weight: bold;"> fee</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 4px;" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: middle; width: 52%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>Common Stock, par value $0.0001 per share</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" colspan="1">
            <div>318,141</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" colspan="1">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" colspan="1">
            <div>2.60</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" colspan="1">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" colspan="1">
            <div>827,166.60</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" colspan="1">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" colspan="1">
            <div>100.25</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: #CCEEFF;" colspan="1">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" id="z21e47baca6bd4f30be3e8c5fee4de646" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 23.95pt; vertical-align: top; align: right;">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify;">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the <font style="font-weight: bold; font-style: italic;">&#8220;Securities Act&#8221;</font>), this Registration Statement shall also cover any
                  additional shares of the Registrant&#8217;s common stock (<font style="font-weight: bold; font-style: italic;">&#8220;Common Stock&#8221;</font>) that become issuable under the Plans (as defined below) by reason of any stock dividend, stock split,
                  recapitalization or any other similar transaction without receipt of consideration that results in an increase in the number of shares of the Registrant&#8217;s outstanding Common Stock.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" id="z05c54ed20e4046ae9b023cca9347215a" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 23.95pt; vertical-align: top; align: right;">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify;">Estimated solely for the purpose of calculating the registration fee pursuant to paragraphs (c) and (h) of Rule 457 under the Securities Act. The offering price per share and aggregate offering price are
                  based upon the average of the high and low prices of the Common Stock as reported on the NASDAQ Capital Market on August 5, 2019, a date within five business days prior to the date of filing of this Registration Statement, for: (i) shares
                  reserved for grant pursuant to the Registrant&#8217;s 2017 Equity Incentive Plan (the <font style="font-weight: bold; font-style: italic;">&#8220;2017 EIP&#8221;</font>); (ii) shares reserved for grant pursuant to the Registrant&#8217;s 2013 Non-Employee
                  Directors&#8217; Equity Incentive Plan (the <font style="font-weight: bold; font-style: italic;">&#8220;Directors&#8217; EIP&#8221;</font>); and (iii) shares reserved for grant pursuant to the Registrant&#8217;s New-Hire Equity Incentive Plan (the <font style="font-weight: bold; font-style: italic;">&#8220;New-Hire Plan&#8221;</font>; and collectively, with the 2017 EIP and the Directors&#8217; EIP, the <font style="font-weight: bold; font-style: italic;">&#8220;Plans&#8221;</font>).</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" align="center" style="width: 90%; color: #000000; font-family: 'Times New Roman'; font-size: 10pt; text-align: left;" id="za9a63a0598ff4d79b6f3b97577dc99cd">

        <tr>
          <td valign="bottom" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); width: 54%;">
            <div>&#160;</div>
            <div style="margin-right: 2.15pt; font-weight: bold;">Securities</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-weight: bold;">Number of Shares</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-weight: bold;">Offering Price</div>
            <div style="text-align: center; font-weight: bold;"> Per Share</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-weight: bold;">Aggregate Offering Price</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 54%; background-color: rgb(204, 238, 255);" colspan="1">
            <div style="text-indent: -10pt; margin-right: 0.8pt; margin-left: 10pt;">Shares reserved for grant under the 2017 EIP</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1">
            <div>42,711</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">
            <div>(3)</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1">
            <div>2.60</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1">
            <div>111,048.60</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; background-color: rgb(255, 255, 255); width: 54%;" colspan="1">
            <div style="text-indent: -10pt; margin-right: 0.8pt; margin-left: 10pt;">Shares reserved for grant under the Directors&#8217; EIP</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; background-color: rgb(255, 255, 255); width: 9%;" colspan="1">
            <div>25,430</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 1%;" colspan="1">
            <div>(4)</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 1%;" colspan="1">&#160;</td>
          <td nowrap="nowrap" style="vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div>$</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">2.60</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 1%;" colspan="1">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; background-color: rgb(255, 255, 255); width: 9%;" colspan="1">
            <div>66,118.00</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 1%;" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; background-color: rgb(204, 238, 255); width: 54%;" colspan="1">
            <div style="text-indent: -10pt; margin-right: 0.8pt; margin-left: 10pt;">Shares reserved for grant under the New-Hire Plan</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; background-color: rgb(204, 238, 255); width: 9%;" colspan="1">
            <div>250,000</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 1%;" colspan="1">
            <div>(5)</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 1%;" colspan="1">&#160;</td>
          <td nowrap="nowrap" style="vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div>$</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">&#160;2.60</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 1%;" colspan="1">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; background-color: rgb(204, 238, 255); width: 9%;" colspan="1">
            <div>650,000</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 1%;" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 54%; background-color: rgb(255, 255, 255);" colspan="1">
            <div style="text-indent: -10pt; margin-right: 0.8pt; margin-left: 10pt;">Proposed Maximum Offering Price</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #FFFFFF;" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #FFFFFF;" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #FFFFFF;" colspan="1">
            <div>827,166.60</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" id="z404aea8371d74848b6207921cde32a1b" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 23.95pt; vertical-align: top;">(3)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify;">Consists of shares that were automatically added to the shares authorized for issuance under the 2017 EIP on January 1, 2019 pursuant to an &#8220;evergreen&#8221; provision contained in the 2017 EIP.&#160; Pursuant to the
                  2017 EIP, the share reserve will automatically increase on January 1st of each year, for a period of not more than ten years, commencing on January 1, 2018 and ending on (and including) January 1, 2027, to an amount equal to thirteen
                  percent (13%) of the fully diluted shares outstanding on December 31st of the preceding calendar year; provided that the Board of Directors may act prior to January 1st of a given year to provide that there will be no January 1st increase
                  in the share reserve for such year or that the increase in the share reserve for such year will be a lesser number of shares than would otherwise occur.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" id="zbb949fdc6df14d83a57b88cc52613ce8" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 23.95pt; vertical-align: top;">(4)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify;">Consists of shares that were automatically added to the shares authorized for issuance under the Directors&#8217; EIP on January 1, 2019 pursuant to an &#8220;evergreen&#8221; provision contained in the Directors&#8217; EIP.&#160;
                  Pursuant to the Directors&#8217; EIP, the share reserve will automatically increase on January 1st of each year, for a period of not more than ten years, commencing on January 1, 2014 and ending on (and including) January 1, 2023, by an amount
                  equal to two percent (2%) of the fully diluted shares outstanding on December 31st of the preceding calendar year; provided that the Board of Directors may act prior to January 1st of a given year to provide that there will be no January
                  1st increase in the share reserve for such year or that the increase in the share reserve for such year will be a lesser number of shares than would otherwise occur.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" id="ze2d6c6af32dd45b882ed8e2161064fcd" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 23.95pt; vertical-align: top;">(5)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify;">Consists of shares reserved for grant under the New-Hire Plan pursuant to a Sixth Amendment to the New-Hire Plan that was approved by the Registrant&#8217;s Board of Directors on May 23, 2019.</div>
              </td>
            </tr>

        </table>
        <div> <br>
        </div>
      </div>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <!--PROfilePageNumberReset%Num%1%%%-->
    <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 27pt;">This Registration Statement on Form S-8 (the <font style="font-weight: bold; font-style: italic;">&#8220;Registration Statement&#8221;</font>) is being filed to register (i) an additional 42,711 shares of
      common stock reserved for grant pursuant to an &#8220;evergreen provision&#8221; of the Registrant&#8217;s 2017 Equity Incentive Plan, (ii) an additional 25,430 shares of common stock reserved for grant pursuant to an &#8220;evergreen provision&#8221; of the Registrant&#8217;s 2013
      Non-Employee Directors&#8217; Equity Incentive Plan, and (iii) an additional 250,000 shares of common stock reserved for grant pursuant to the Registrant&#8217;s New-Hire Equity Incentive Plan.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">INCORPORATION BY REFERENCE OF CONTENTS OF</div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENTS ON FORM S-8</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 27pt;">The contents of the Registration Statements on Form S-8 previously filed with the Securities and Exchange Commission (the <font style="font-weight: bold; font-style: italic;">&#8220;Commission&#8221;</font>) <a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465912063566/a12-21137_1s8.htm">on September 14, 2012 (File No. 333-183925)</a>, <a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465913045567/a13-13334_1s8.htm">May 30, 2013
        (File No. 333-188935)</a>, <a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465913062056/a13-18138_1s8.htm">August 9, 2013 (File No. 333-190499)</a>, <a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465914020495/a14-8302_1s8.htm">March 18, 2014 (File No. 333-194642)</a>, <a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465915021399/a15-7344_1s8.htm">March 20, 2015 (File
        No. 333-202904)</a>, <a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465916105225/a16-6324_1s8.htm">March 15, 2016 (File No. 333-210215)</a>, <a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465917037240/a17-14441_1s8.htm">June 2, 2017 (File No. 333-218464)</a> and <a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036118014796/forms8.htm">March 23, 2018 (File No.
        333-223879)</a> are incorporated by reference herein.</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">PART I</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN PROSPECTUS</div>
    <div>&#160;</div>
    <div style="text-indent: 27pt;">The documents containing the information required in this Part I will be delivered to the participants in the Plan, as specified in Rule 428(b)(1) of the Securities Act. Such documents are not required to be filed with
      the Commission as part of this Registration Statement.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">PART II</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div>&#160;</div>
    <div>
      <table cellspacing="0" cellpadding="0" id="ze2138d87820345e1a7a47cfe76978f03" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45pt; vertical-align: top;"><font style="font-weight: bold;">Item 3.</font></td>
            <td style="vertical-align: top;">
              <div><font style="font-weight: bold;">Incorporation of Documents by Reference.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"> <br>
    </div>
    <div style="text-align: justify; text-indent: 27pt;">The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 45.8pt;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160; The Registrant&#8217;s <a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119003638/s002681x1_10k.htm">Annual Report on Form 10-K</a> for the year ended December 31, 2018, filed
      with the Commission on February 21, 2019 (including information specifically incorporated by reference therein from the Registrant&#8217;s <a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119006790/s002765x1_def14a.htm">Proxy Statement</a>
      filed with the Commission on April 9, 2019);</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 45.8pt;">(b)&#160;&#160; &#160; &#160;&#160; The Registrant&#8217;s Quarterly Reports on Form 10-Q for the quarters <a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119008866/form10q.htm">ended March 31, 2019</a> and <a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119014608/form10q.htm"> June 30, 2019</a>, filed with the Commission on May 9, 2019 and August 8, 2019, respectively;</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 45.8pt;">(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; The Registrant&#8217;s Current Reports on Form 8-K filed with the Commission on <a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119000021/s002610x2_8k.htm">January 2, 2019</a>,
      <a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119001614/s002610x4_8k.htm">January 25, 2019</a>,&#160; <a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119004855/form8k.htm">March 13, 2019</a>, and <a href="http://www.sec.gov/Archives/edgar/data/1506492/000156761919012129/form8k.htm">May 24, 2019</a>; and</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 45.8pt;">(d)&#160;&#160;&#160;&#160;&#160;&#160; The description of the Registrant&#8217;s Common Stock contained in the Registration Statement on <a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465911054367/a11-26786_11012b.htm">Form 10 (File No. 001-35312)</a> filed pursuant to Section 12(b) on September 30, 2011 and all amendments thereto.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 27pt;">In addition, all documents the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the <font style="font-weight: bold; font-style: italic;">&#8220;Exchange Act&#8221;</font>), after the filing of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities
      covered hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part hereof from the date of filing of such documents.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">1</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: justify; text-indent: 27pt;">Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the
      extent that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated by reference herein, modifies or supersedes such prior statement. Any such statement so modified or superseded shall not be
      deemed, except as so modified or superseded, to constitute part of this Registration Statement.</div>
    <div>&#160;</div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z54764391fd2c4a26a4beabd98d10a633" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 45pt;">
              <div style="text-align: left; text-indent: -36pt; margin-left: 36pt; font-weight: bold;">Item 4.</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left; text-indent: -36pt; margin-left: 36pt; font-weight: bold;">Description of Securities.</div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <div style="text-indent: 27pt;">Not applicable.</div>
    <div style="text-align: center;"> <br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z31e083c3282345c5b38c9065716ffc58" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 45pt;">
              <div style="text-align: left; text-indent: -36pt; margin-left: 36pt; font-weight: bold;">Item 5.</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left; text-indent: -36pt; margin-left: 36pt; font-weight: bold;">Interests of Named Experts and Counsel.</div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <div style="text-indent: 27pt;">Not applicable.</div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z6d76049e211e4a558f3cae4034491a41" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 45pt;">
              <div style="text-align: left; text-indent: -36pt; margin-left: 36pt; font-weight: bold;">Item 6.</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left; text-indent: -36pt; margin-left: 36pt; font-weight: bold;">Indemnification of Directors and Officers.</div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <div style="text-indent: 27pt; text-align: justify;">The Registrant&#8217;s Fourth Amended and Restated Certificate of Incorporation, as amended limits the liability of the Registrant&#8217;s directors to the fullest extent permitted by Delaware law.&#160; Delaware law
      provides that directors of a corporation will not be personally liable for monetary damages for breach of their fiduciary duties as directors, except for liability for any:</div>
    <div> </div>
    <div> <br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z24d0604d636942abbfd7db5d339146b3" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="width: 27pt;">&#160;</td>
            <td style="vertical-align: top; width: 18pt;">
              <div style="text-align: left;">
                <div>&#8226;</div>
              </div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;">
                <div>breach of their duty of loyalty to the Registrant or the Registrant&#8217;s stockholders;</div>
              </div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-indent: -18pt; margin-left: 54pt;"> <br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="zd78faa48bef94d869609955f88dd36e9" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="width: 27pt;">&#160;</td>
            <td style="vertical-align: top; width: 18pt;">
              <div style="text-align: left;">
                <div>
                  <div>&#8226;</div>
                </div>
              </div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;">act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-indent: -18pt; margin-left: 54pt;"> <br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z6d71886d2e714c11a76eceb6d5b40518" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="width: 27pt;">&#160;</td>
            <td style="vertical-align: top; width: 18pt;">
              <div style="text-align: left;">
                <div>
                  <div>&#8226;</div>
                </div>
              </div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;">
                <div>unlawful payment of dividends or redemption of shares as provided in Section 174 of the Delaware General Corporation Law; or</div>
              </div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-indent: -18pt; margin-left: 54pt;"> <br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="zd9d71479e71341cba211878f0fd6a449" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="width: 27pt;">&#160;</td>
            <td style="vertical-align: top; width: 18pt;">
              <div style="text-align: left;">
                <div>
                  <div>&#8226;</div>
                </div>
              </div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;">
                <div>transaction from which the directors derived an improper personal benefit.</div>
              </div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-indent: -18pt; margin-left: 54pt;"> <br>
    </div>
    <div style="text-indent: 27pt; text-align: justify;">These limitations of liability do not apply to liabilities arising under federal securities laws and do not affect the availability of equitable remedies such as injunctive relief or rescission.</div>
    <div style="text-indent: 36pt;"> <br>
    </div>
    <div style="text-indent: 27pt; text-align: justify;">The Registrant&#8217;s bylaws provide that it will indemnify and advance expenses to its directors and officers to the fullest extent permitted by law or, if applicable, pursuant to indemnification
      agreements. The bylaws further provide that the Registrant may choose to indemnify its other employees or agents from time to time. Subject to certain exceptions and procedures, the Registrant&#8217;s bylaws also require it to advance to any person who was
      or is a party, or is threatened to be made a party, to any proceeding by reason of the person&#8217;s service as one of the Registrant&#8217;s directors or officers all expenses incurred by the person in connection with such proceeding.</div>
    <div style="text-indent: 36pt;"> <br>
    </div>
    <div style="text-indent: 27pt; text-align: justify;">Section 145(g) of the Delaware General Corporation Law and the Registrant&#8217;s bylaws also permit it to secure insurance on behalf of any officer, director, employee or other agent for any liability
      arising out of his or her actions in connection with their services to us, regardless of whether the Registrant&#8217;s bylaws permit indemnification. The Registrant maintains a directors&#8217; and officers&#8217; liability insurance policy.</div>
    <div style="text-indent: 36pt;"> <br>
    </div>
    <div style="text-indent: 27pt; text-align: justify;">The Registrant entered into indemnification agreements with each of its directors and executive officers that provide, in general, that the Registrant will indemnify them to the fullest extent
      permitted by law in connection with their service to the Registrant or on its behalf and, subject to certain exceptions and procedures, that the Registrant will advance to them all expenses that they incur in connection with any proceeding to which
      they are, or are threatened to be, a party.</div>
    <div style="text-indent: 36pt;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">2</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-indent: 27pt;">At present, there is no pending litigation or proceeding involving any of the Registrant&#8217;s directors or officers as to which indemnification is required or permitted, and the Registrant is not aware of any threatened
      litigation or proceeding that may result in a claim for indemnification.</div>
    <div style="text-indent: 36pt;"> <br>
    </div>
    <div style="text-indent: 27pt;">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the
      registrant has been advised that in the opinion of the Securities and Exchange Commission this indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.</div>
    <div style="text-indent: 36pt;"> <br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z902b79c93f424f05ab8b4701c6b2d432" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 45pt;">
              <div style="text-align: left; text-indent: -36pt; margin-left: 36pt; font-weight: bold;">Item 7.</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left; text-indent: -36pt; margin-left: 36pt; font-weight: bold;">Exemption from Registration Claimed.</div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <div style="text-indent: 27pt;">Not applicable.</div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="z501d414c17514640a93740c3a8618fba" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45pt; vertical-align: top;"><font style="font-weight: bold;">Item 8.</font></td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="font-weight: bold;">Exhibits.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;">EXHIBIT INDEX</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="zf40df92c51fa49d0b9619732da4008be" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 10%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 30%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="text-align: center; font-weight: bold;">Incorporated By Reference</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 5.8%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.52%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-weight: bold;"> Number</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 30%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-weight: bold;"> Description</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Form</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 15%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">File</div>
            <div style="text-align: center; font-weight: bold;"> Number</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Date of First</div>
            <div style="text-align: center; font-weight: bold;"> Filing</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 5.8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-weight: bold;"> Number</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.52%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Filed</div>
            <div style="text-align: center; font-weight: bold;"> Herewith</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 15%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 20%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 5.8%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 6.52%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465912005820/a11-26786_1ex3d1.htm">4.1</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Fourth Amended and Restated Certificate of Incorporation</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">10</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">February 1, 2012</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465917002209/a17-1987_1ex3d1.htm">4.2</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">January 13, 2017</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465917034447/a17-13940_1ex3d1.htm">4.3</a></div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">May 23, 2017</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036117038508/ex3_1.htm">4.4</a></div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">October 12, 2017</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119000021/s002610x2_ex3-1.htm">4.5</a></div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">January 2, 2019</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465917034447/a17-13940_1ex3d2.htm">4.6</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Second Amended and Restated Bylaws</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">May 23, 2017</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3.2</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465913049339/a13-14837_1ex3d1.htm">4.7</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Form of Certificate of Designation of Series A Junior Participating Preferred Stock</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">June 14, 2013</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000156761917002350/s001918x7_ex3-7.htm">4.8</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Form of Certificate of Designation of Preferences, Rights and Limitations of Series F Convertible Preferred Stock</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">&#160;S-1/A</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">&#160;333-221010</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">&#160;November 17, 2017</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">&#160;3.7</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119004855/ex3_1.htm">4.9</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; color: rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
            <div>Certificate of Designation of Preferences, Rights and Limitations of Series G Convertible Preferred Stock</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">March 13, 2019</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">3.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465915011850/a15-4910_1ex4d1.htm">4.10</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Warrant to Purchase Stock, dated February 18, 2015, issued to Silicon Valley Bank</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">February 19, 2015</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">3</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z04b611c0e5794194afe8cfea6f9f43ac" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="vertical-align: bottom; width: 10%; padding-bottom: 2px;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 30%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="text-align: center; font-weight: bold;">Incorporated By Reference</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 5.8%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 6.52%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td style="vertical-align: bottom; width: 10%; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-weight: bold;"> Number</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 30%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-weight: bold;"> Description</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Form</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 15%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">File</div>
            <div style="text-align: center; font-weight: bold;"> Number</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Date of First</div>
            <div style="text-align: center; font-weight: bold;">Filing</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 5.8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-weight: bold;"> Number</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 6.52%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Filed</div>
            <div style="text-align: center; font-weight: bold;"> Herewith</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 30%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 6%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 15%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 20%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 5.8%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 6.52%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465915011850/a15-4910_1ex4d2.htm">4.11</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Warrant to Purchase Stock, dated February 18, 2015, issued to Life Science Loans, LLC</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">February 19, 2015</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.2</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465916133890/a16-15345_2ex4d2.htm">4.12</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Form of common stock Purchase Warrant issued pursuant to the Securities Purchase Agreement, dated July 20, 2016, among the Company and the purchasers signatory thereto</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">July 22, 2016</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.2</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465916133890/a16-15345_2ex4d3.htm">4.13</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Form of common stock Purchase Warrant issued to Northland Securities, Inc.</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">July 22, 2016</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.3</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465916137720/a16-16318_1ex4d1.htm">4.14</a></div>
            &#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Registration Rights Agreement between Sunshine Heart, Inc. and Gambro UF Solutions, Inc. dated August 5, 2016</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">August 8, 2016</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465916153257/a16-20755_1ex4d1.htm">4.15</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Form of common stock Purchase Warrant issued pursuant to the Securities Purchase Agreement, dated October 30, 2016, among the Company and the purchasers signatory thereto</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">October 31, 2016</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000110465917009767/a17-4580_1ex4d1.htm">4.16</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Form of common stock Purchase Warrant issued pursuant to the Letter Agreement between the Company and the purchasers signatory thereto, dated February 15, 2017</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">February 16, 2017</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000104746917002343/a2231670zex-4_8.htm">4.17</a></div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Form of common stock Purchase Warrant issued pursuant to the Underwriting Agreement between the Company and Ladenburg Thalmann &amp; Co. Inc., dated April 19, 2017</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">S-1/A</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">333-216841</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">April 4, 2017</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.8</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000156761917002350/s001918x7_ex4-9.htm">4.18</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Form of Warrant to purchase shares of common stock</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">S-1/A</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">&#160;333-221010</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">&#160;November 17, 2017</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.9</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119003726/s002610x5_ex4-10.htm">4.19</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; color: rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
            <div>Form of Series 1 and Series 2 Warrant to purchase shares of common stock</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">S-1/A</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">333-229102</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">February 25, 2019</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">4.10</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; color: rgb(0, 0, 0);"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119004855/ex4_2.htm">4.20</a></div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; color: rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
            <div>Warrant Agency Agreement, dated as of March 12, 2019, between CHF Solutions, Inc. and American Stock Transfer &amp; Trust Company, LLC</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">8-K</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">March 13, 2019</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">4.2</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119014608/ex4_1.htm">4.21</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: #000000;">Warrant, dated May 30, 2019 between CHF Solutions, Inc. and Redington, Inc.</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">10-Q</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; color: #000000;">001-35312</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">August 8, 2019</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.1</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">4</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <table cellspacing="0" cellpadding="0" id="z2db76a5aaeef4d239b1b012841cb7126" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 10%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 30%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="text-align: center; font-weight: bold;">Incorporated By Reference</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 5.8%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="vertical-align: bottom; padding-bottom: 2px;" colspan="2">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-weight: bold;"> Number</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 30%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-weight: bold;"> Description</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Form</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 15%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;"> File</div>
            <div style="text-align: center; font-weight: bold;"> Number</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Date of First</div>
            <div style="text-align: center; font-weight: bold;"> Filing</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td style="width: 5.8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-weight: bold;"> Number</div>
          </td>
          <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-weight: bold;">Filed</div>
            <div style="text-align: center; font-weight: bold;"> Herewith</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 30%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 6%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 15%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 20%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 5.8%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 6.52%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="ex5_1.htm">5.1</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Opinion of Honigman LLP</div>
            <div>&#160;</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="ex23_1.htm">23.1</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Consent of Baker Tilly Virchow Krause, LLP</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="ex5_1.htm">23.2</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Consent of Honigman LLP<font style="color: #000000;">&#160;</font>(included in its opinion filed as Exhibit 5.1 to this Registration Statement)</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; text-indent: -9pt; margin-left: 9pt;"><a href="#SIGNATURES">24</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Power of Attorney (included on signature page)</div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;" rowspan="1"><a href="http://www.sec.gov/Archives/edgar/data/1506492/000114036119014608/ex10_2.htm">99.1</a></td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 30%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">Sixth Amendment to New-Hire Equity Incentive Plan&#8224; </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;" rowspan="1">10-Q</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 15%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;" rowspan="1">001-35312<br>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 20%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;" rowspan="1">August 8, 2019<br>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 5.8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;" rowspan="1">10.2</td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 6.52%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>
      <div style="color: rgb(0, 0, 0); margin-left: 18pt;">&#8224; Indicates management compensatory plan, contract or arrangement</div>
    </div>
    <div><br>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" id="z85cf94c835fb4d0ebbf922f3bad6bcfd" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 45pt; vertical-align: top; font-weight: bold;">Item 9.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;">Undertakings.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div> <br>
    </div>
    <div style="text-indent: -36pt; margin-left: 36pt;">(a)&#160; &#160; &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; The Registrant hereby undertakes:</div>
    <div style="text-indent: -36pt; margin-left: 36pt;"> <br>
    </div>
    <div style="margin-left: 45pt;">(1)&#160; &#160; &#160; To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</div>
    <div style="text-indent: -36pt; margin-left: 72pt;"> <br>
    </div>
    <div style="text-indent: -36pt; margin-left: 108pt;">(i)&#160; &#160; &#160; &#160;&#160;&#160; To include any prospectus required by Section 10(a)(3) of the Securities Act;</div>
    <div style="text-indent: -36pt; margin-left: 108pt;"> <br>
    </div>
    <div style="text-indent: -36pt; margin-left: 108pt; text-align: justify;">(ii)&#160;&#160; &#160; &#160;&#160;&#160; To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof)
      which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement.&#160; Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
      securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
      aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective Registration Statement;</div>
    <div style="text-indent: -36pt; margin-left: 108pt;"> <br>
    </div>
    <div style="text-indent: -36pt; margin-left: 108pt; text-align: justify;">(iii)&#160; &#160; &#160; &#160; to include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such
      information in the Registration Statement;</div>
    <div style="text-indent: -36pt; margin-left: 108pt;"> <br>
    </div>
    <div style="text-indent: 72pt; text-align: justify;"><font style="font-style: italic;">provided, however, </font>that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those
      paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement; and</div>
    <div style="text-indent: 36pt;"> <br>
    </div>
    <div style="text-indent: -27pt; margin-left: 72pt; text-align: justify;">(2)&#160; &#160;&#160;&#160; That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement
      relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
    <div style="text-indent: -36pt; margin-left: 72pt;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">5</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-indent: -27pt; margin-left: 72pt;">(3)&#160; &#160;&#160;&#160; To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
    <div style="text-align: center;"> <br>
    </div>
    <div style="text-align: justify;">(b)&#160; &#160; &#160; &#160;&#160;&#160; &#160; &#160; The Registrant hereby undertakes that, for the purpose of determining any liability under the Securities Act, each filing of the Registrant&#8217;s annual report pursuant to Section 13(a) or Section 15(d) of
      the Exchange Act (and, where applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration
      statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
    <div> <br>
    </div>
    <div style="text-align: justify;">(c)&#160; &#160; &#160; &#160;&#160; &#160; &#160;&#160; Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or
      otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.&#160; In the event that a claim for indemnification against
      such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer
      or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
      whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</div>
    <div> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">6</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; font-weight: bold;"><a name="SIGNATURES"><!--Anchor--></a>SIGNATURES</div>
    <div>&#160;</div>
    <div style="text-align: justify;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
      Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Eden Prairie, State of Minnesota, on August 8, 2019.</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" border="0" id="z0c29188d80cb4a8ca090720545c4684a" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;" colspan="2">
            <div>CHF SOLUTIONS, INC.</div>
          </td>
          <td style="width: 20%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
          <td style="width: 20%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div>By:</div>
          </td>
          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid black;">
            <div>&#160;/s/ <font style="font-variant: small-caps;">John L. Erb</font></div>
          </td>
          <td style="width: 20%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div>Name:</div>
          </td>
          <td style="width: 25%; vertical-align: top;">
            <div>John L. Erb</div>
          </td>
          <td style="width: 20%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div>Title:</div>
          </td>
          <td style="width: 25%; vertical-align: top;">
            <div>Chief Executive Officer</div>
          </td>
          <td style="width: 20%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify;">We, the undersigned officers and directors of CHF Solutions, Inc., hereby constitute John L. Erb and Claudia Drayton, as the true and lawful attorneys with full power to them, and each of them singly to sign for us and
      in our names, in the capacities indicated below the Registration Statement filed herewith and any amendments to said Registration Statement, and generally to do all such things in our name and behalf in our capacities as officers and directors to
      enable CHF Solutions, Inc. to comply with the provisions of the Securities Act of 1933 and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any
      of them, to said Registration Statement and any and all amendments thereto.&#160; Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates
      indicated.</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" border="0" id="z0ce9073141b44d748810d1687904601f" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div style="text-align: center;"><u>SIGNATURE</u></div>
          </td>
          <td style="width: 45.06%; vertical-align: top;">
            <div style="text-align: center;"><u>TITLE</u></div>
          </td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center;"><u>DATE</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ J<font style="font-variant: small-caps;">ohn</font> L. E<font style="font-variant: small-caps;">rb</font></div>
          </td>
          <td style="width: 45.06%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">President, CEO and Chairman</div>
          </td>
          <td style="width: 25%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">August 8, 2019</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>John L. Erb</div>
          </td>
          <td style="width: 45.06%; vertical-align: top;">
            <div style="text-align: center;">(principal executive officer)</div>
          </td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Claudia Drayton</font></div>
          </td>
          <td style="width: 45.06%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Chief Financial Officer</div>
          </td>
          <td style="width: 25%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">August 8, 2019</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Claudia Drayton</div>
          </td>
          <td style="width: 45.06%; vertical-align: top;">
            <div style="text-align: center;">(principal financial and accounting officer)</div>
          </td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Steve Brandt</font></div>
          </td>
          <td style="width: 45.06%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 25%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">August 8, 2019</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Steve Brandt</div>
          </td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Matthew Likens</font></div>
          </td>
          <td style="width: 45.06%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 25%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">August 8, 2019</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Matthew Likens</div>
          </td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Jon W. Salveson</font></div>
          </td>
          <td style="width: 45.06%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 25%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">August 8, 2019</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Jon W. Salveson</div>
          </td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Gregory D. Waller</font></div>
          </td>
          <td style="width: 45.06%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 25%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">August 8, 2019</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Gregory D. Waller</div>
          </td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Warren S. Watson</font></div>
          </td>
          <td style="width: 45.06%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 25%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">August 8, 2019</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Warren S. Watson</div>
          </td>
          <td style="width: 45.06%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">7</font></div>
    <div>
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
  </div>
</body>
</html>
[{"type": "S-8", "sequence": "1", "filename": "forms8.htm", "description": "S-8", "secsgml_size_bytes": 171894}]
{"company-data": {"conformed-name": "CHF Solutions, Inc.", "cik": "0001506492", "assigned-sic": "3845", "irs-number": "680533453", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-233152", "film-number": "191010684"}, "business-address": {"street1": "12988 VALLEY VIEW ROAD", "city": "EDEN PRAIRIE", "state": "MN", "zip": "55344", "phone": "952-345-4200"}, "mail-address": {"street1": "12988 VALLEY VIEW ROAD", "city": "EDEN PRAIRIE", "state": "MN", "zip": "55344"}, "former-company": {"former-conformed-name": "Sunshine Heart, Inc.", "date-changed": "20101124"}}
As filed with the Securities and Exchange Commission on August 8, 2019
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
CHF Solutions, Inc.
(Exact name of registrant as specified in its charter)
Delaware
68-0533453
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
12988 Valley View Road
Eden Prairie, Minnesota
55344
(Address of Principal Executive Offices)
(Zip Code)
CHF Solutions, Inc. 2017 Equity Incentive Plan
CHF Solutions, Inc. 2013 Non-Employee Directors' Equity Incentive Plan
CHF Solutions, Inc. New-Hire Equity Incentive Plan
(Full title of the plan)
John L. Erb
Chief Executive Officer
CHF Solutions, Inc.
12988 Valley View Road
Eden Prairie, MN 55344
(952) 345-4200
(Name, address and telephone number, including area code, of agent for service)
Copies to:
Phillip D. Torrence, Esq.
Meredith Ervine, Esq.
Honigman LLP
650 Trade Center Way, Ste 200
Kalamazoo, MI 49002
(269) 337-7700
Thomas P. Lynch
General Counsel
CHF Solutions, Inc.
12988 Valley View Road
Eden Prairie, MN 55344
(952) 345-4200
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
      filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☐     Accelerated filer  ☐
Non-accelerated filer ☒      Smaller reporting company  ☒
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. ☐
CALCULATION OF REGISTRATION FEE
Title of securities to be registered
Amount to be
Registered (1)
Proposed maximum
offering price
per share (2)
Proposed maximum
aggregate offering
price (2)
Amount of
registration
fee
Common Stock, par value $0.0001 per share
318,141
$
2.60
$
827,166.60
$
100.25
(1)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the
"Securities Act"
), this Registration Statement shall also cover any
                  additional shares of the Registrant's common stock (
"Common Stock"
) that become issuable under the Plans (as defined below) by reason of any stock dividend, stock split,
                  recapitalization or any other similar transaction without receipt of consideration that results in an increase in the number of shares of the Registrant's outstanding Common Stock.
(2)
Estimated solely for the purpose of calculating the registration fee pursuant to paragraphs (c) and (h) of Rule 457 under the Securities Act. The offering price per share and aggregate offering price are
                  based upon the average of the high and low prices of the Common Stock as reported on the NASDAQ Capital Market on August 5, 2019, a date within five business days prior to the date of filing of this Registration Statement, for: (i) shares
                  reserved for grant pursuant to the Registrant's 2017 Equity Incentive Plan (the
"2017 EIP"
); (ii) shares reserved for grant pursuant to the Registrant's 2013 Non-Employee
                  Directors' Equity Incentive Plan (the
"Directors' EIP"
); and (iii) shares reserved for grant pursuant to the Registrant's New-Hire Equity Incentive Plan (the
"New-Hire Plan"
; and collectively, with the 2017 EIP and the Directors' EIP, the
"Plans"
).
Securities
Number of Shares
Offering Price
Per Share
Aggregate Offering Price
Shares reserved for grant under the 2017 EIP
42,711
(3)
$
2.60
$
111,048.60
Shares reserved for grant under the Directors' EIP
25,430
(4)
$
2.60
$
66,118.00
Shares reserved for grant under the New-Hire Plan
250,000
(5)
$
2.60
$
650,000
Proposed Maximum Offering Price
$
827,166.60
(3)
Consists of shares that were automatically added to the shares authorized for issuance under the 2017 EIP on January 1, 2019 pursuant to an "evergreen" provision contained in the 2017 EIP.  Pursuant to the
                  2017 EIP, the share reserve will automatically increase on January 1st of each year, for a period of not more than ten years, commencing on January 1, 2018 and ending on (and including) January 1, 2027, to an amount equal to thirteen
                  percent (13%) of the fully diluted shares outstanding on December 31st of the preceding calendar year; provided that the Board of Directors may act prior to January 1st of a given year to provide that there will be no January 1st increase
                  in the share reserve for such year or that the increase in the share reserve for such year will be a lesser number of shares than would otherwise occur.
(4)
Consists of shares that were automatically added to the shares authorized for issuance under the Directors' EIP on January 1, 2019 pursuant to an "evergreen" provision contained in the Directors' EIP. 
                  Pursuant to the Directors' EIP, the share reserve will automatically increase on January 1st of each year, for a period of not more than ten years, commencing on January 1, 2014 and ending on (and including) January 1, 2023, by an amount
                  equal to two percent (2%) of the fully diluted shares outstanding on December 31st of the preceding calendar year; provided that the Board of Directors may act prior to January 1st of a given year to provide that there will be no January
                  1st increase in the share reserve for such year or that the increase in the share reserve for such year will be a lesser number of shares than would otherwise occur.
(5)
Consists of shares reserved for grant under the New-Hire Plan pursuant to a Sixth Amendment to the New-Hire Plan that was approved by the Registrant's Board of Directors on May 23, 2019.
EXPLANATORY NOTE
This Registration Statement on Form S-8 (the
"Registration Statement"
) is being filed to register (i) an additional 42,711 shares of
      common stock reserved for grant pursuant to an "evergreen provision" of the Registrant's 2017 Equity Incentive Plan, (ii) an additional 25,430 shares of common stock reserved for grant pursuant to an "evergreen provision" of the Registrant's 2013
      Non-Employee Directors' Equity Incentive Plan, and (iii) an additional 250,000 shares of common stock reserved for grant pursuant to the Registrant's New-Hire Equity Incentive Plan.
INCORPORATION BY REFERENCE OF CONTENTS OF
REGISTRATION STATEMENTS ON FORM S-8
The contents of the Registration Statements on Form S-8 previously filed with the Securities and Exchange Commission (the
"Commission"
)
on September 14, 2012 (File No. 333-183925)
,
May 30, 2013
        (File No. 333-188935)
,
August 9, 2013 (File No. 333-190499)
,
March 18, 2014 (File No. 333-194642)
,
March 20, 2015 (File
        No. 333-202904)
,
March 15, 2016 (File No. 333-210215)
,
June 2, 2017 (File No. 333-218464)
and
March 23, 2018 (File No.
        333-223879)
are incorporated by reference herein.
PART I
INFORMATION REQUIRED IN PROSPECTUS
The documents containing the information required in this Part I will be delivered to the participants in the Plan, as specified in Rule 428(b)(1) of the Securities Act. Such documents are not required to be filed with
      the Commission as part of this Registration Statement.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:
(a)        The Registrant's
Annual Report on Form 10-K
for the year ended December 31, 2018, filed
      with the Commission on February 21, 2019 (including information specifically incorporated by reference therein from the Registrant's
Proxy Statement
filed with the Commission on April 9, 2019);
(b)        The Registrant's Quarterly Reports on Form 10-Q for the quarters
ended March 31, 2019
and
June 30, 2019
, filed with the Commission on May 9, 2019 and August 8, 2019, respectively;
(c)         The Registrant's Current Reports on Form 8-K filed with the Commission on
January 2, 2019
,
January 25, 2019
,
March 13, 2019
, and
May 24, 2019
; and
(d)       The description of the Registrant's Common Stock contained in the Registration Statement on
Form 10 (File No. 001-35312)
filed pursuant to Section 12(b) on September 30, 2011 and all amendments thereto.
In addition, all documents the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the
"Exchange Act"
), after the filing of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities
      covered hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part hereof from the date of filing of such documents.
1
Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the
      extent that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated by reference herein, modifies or supersedes such prior statement. Any such statement so modified or superseded shall not be
      deemed, except as so modified or superseded, to constitute part of this Registration Statement.
Item 4.
Description of Securities.
Not applicable.
Item 5.
Interests of Named Experts and Counsel.
Not applicable.
Item 6.
Indemnification of Directors and Officers.
The Registrant's Fourth Amended and Restated Certificate of Incorporation, as amended limits the liability of the Registrant's directors to the fullest extent permitted by Delaware law.  Delaware law
      provides that directors of a corporation will not be personally liable for monetary damages for breach of their fiduciary duties as directors, except for liability for any:
•
breach of their duty of loyalty to the Registrant or the Registrant's stockholders;
•
act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;
•
unlawful payment of dividends or redemption of shares as provided in Section 174 of the Delaware General Corporation Law; or
•
transaction from which the directors derived an improper personal benefit.
These limitations of liability do not apply to liabilities arising under federal securities laws and do not affect the availability of equitable remedies such as injunctive relief or rescission.
The Registrant's bylaws provide that it will indemnify and advance expenses to its directors and officers to the fullest extent permitted by law or, if applicable, pursuant to indemnification
      agreements. The bylaws further provide that the Registrant may choose to indemnify its other employees or agents from time to time. Subject to certain exceptions and procedures, the Registrant's bylaws also require it to advance to any person who was
      or is a party, or is threatened to be made a party, to any proceeding by reason of the person's service as one of the Registrant's directors or officers all expenses incurred by the person in connection with such proceeding.
Section 145(g) of the Delaware General Corporation Law and the Registrant's bylaws also permit it to secure insurance on behalf of any officer, director, employee or other agent for any liability
      arising out of his or her actions in connection with their services to us, regardless of whether the Registrant's bylaws permit indemnification. The Registrant maintains a directors' and officers' liability insurance policy.
The Registrant entered into indemnification agreements with each of its directors and executive officers that provide, in general, that the Registrant will indemnify them to the fullest extent
      permitted by law in connection with their service to the Registrant or on its behalf and, subject to certain exceptions and procedures, that the Registrant will advance to them all expenses that they incur in connection with any proceeding to which
      they are, or are threatened to be, a party.
2
At present, there is no pending litigation or proceeding involving any of the Registrant's directors or officers as to which indemnification is required or permitted, and the Registrant is not aware of any threatened
      litigation or proceeding that may result in a claim for indemnification.
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the
      registrant has been advised that in the opinion of the Securities and Exchange Commission this indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.
Item 7.
Exemption from Registration Claimed.
Not applicable.
Item 8.
Exhibits.
EXHIBIT INDEX
Incorporated By Reference
Exhibit
Number
Exhibit
Description
Form
File
Number
Date of First
Filing
Exhibit
Number
Filed
Herewith
4.1
Fourth Amended and Restated Certificate of Incorporation
10
001-35312
February 1, 2012
3.1
4.2
Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation
8-K
001-35312
January 13, 2017
3.1
4.3
Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation
8-K
001-35312
May 23, 2017
3.1
4.4
Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation
8-K
001-35312
October 12, 2017
3.1
4.5
Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation
8-K
001-35312
January 2, 2019
3.1
4.6
Second Amended and Restated Bylaws
8-K
001-35312
May 23, 2017
3.2
4.7
Form of Certificate of Designation of Series A Junior Participating Preferred Stock
8-K
001-35312
June 14, 2013
3.1
4.8
Form of Certificate of Designation of Preferences, Rights and Limitations of Series F Convertible Preferred Stock
S-1/A
333-221010
November 17, 2017
3.7
4.9
Certificate of Designation of Preferences, Rights and Limitations of Series G Convertible Preferred Stock
8-K
001-35312
March 13, 2019
3.1
4.10
Warrant to Purchase Stock, dated February 18, 2015, issued to Silicon Valley Bank
8-K
001-35312
February 19, 2015
4.1
3
Incorporated By Reference
Exhibit
Number
Exhibit
Description
Form
File
Number
Date of First
Filing
Exhibit
Number
Filed
Herewith
4.11
Warrant to Purchase Stock, dated February 18, 2015, issued to Life Science Loans, LLC
8-K
001-35312
February 19, 2015
4.2
4.12
Form of common stock Purchase Warrant issued pursuant to the Securities Purchase Agreement, dated July 20, 2016, among the Company and the purchasers signatory thereto
8-K
001-35312
July 22, 2016
4.2
4.13
Form of common stock Purchase Warrant issued to Northland Securities, Inc.
8-K
001-35312
July 22, 2016
4.3
4.14
Registration Rights Agreement between Sunshine Heart, Inc. and Gambro UF Solutions, Inc. dated August 5, 2016
8-K
001-35312
August 8, 2016
4.1
4.15
Form of common stock Purchase Warrant issued pursuant to the Securities Purchase Agreement, dated October 30, 2016, among the Company and the purchasers signatory thereto
8-K
001-35312
October 31, 2016
4.1
4.16
Form of common stock Purchase Warrant issued pursuant to the Letter Agreement between the Company and the purchasers signatory thereto, dated February 15, 2017
8-K
001-35312
February 16, 2017
4.1
4.17
Form of common stock Purchase Warrant issued pursuant to the Underwriting Agreement between the Company and Ladenburg Thalmann & Co. Inc., dated April 19, 2017
S-1/A
333-216841
April 4, 2017
4.8
4.18
Form of Warrant to purchase shares of common stock
S-1/A
333-221010
November 17, 2017
4.9
4.19
Form of Series 1 and Series 2 Warrant to purchase shares of common stock
S-1/A
333-229102
February 25, 2019
4.10
4.20
Warrant Agency Agreement, dated as of March 12, 2019, between CHF Solutions, Inc. and American Stock Transfer & Trust Company, LLC
8-K
001-35312
March 13, 2019
4.2
4.21
Warrant, dated May 30, 2019 between CHF Solutions, Inc. and Redington, Inc.
10-Q
001-35312
August 8, 2019
4.1
4
Incorporated By Reference
Exhibit
Number
Exhibit
Description
Form
File
Number
Date of First
Filing
Exhibit
Number
Filed
Herewith
5.1
Opinion of Honigman LLP
X
23.1
Consent of Baker Tilly Virchow Krause, LLP
X
23.2
Consent of Honigman LLP
(included in its opinion filed as Exhibit 5.1 to this Registration Statement)
X
24
Power of Attorney (included on signature page)
X
99.1
Sixth Amendment to New-Hire Equity Incentive Plan†
10-Q
001-35312
August 8, 2019
10.2
† Indicates management compensatory plan, contract or arrangement
Item 9.
Undertakings.
(a)              The Registrant hereby undertakes:
(1)      To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)          To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)         To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof)
      which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement.  Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
      securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
      aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective Registration Statement;
(iii)        to include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such
      information in the Registration Statement;
provided, however,
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those
      paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement; and
(2)      That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement
      relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
5
(3)      To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)              The Registrant hereby undertakes that, for the purpose of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of
      the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration
      statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c)              Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or
      otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.  In the event that a claim for indemnification against
      such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer
      or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
      whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
6
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
      Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Eden Prairie, State of Minnesota, on August 8, 2019.
CHF SOLUTIONS, INC.
By:
/s/
John L. Erb
Name:
John L. Erb
Title:
Chief Executive Officer
We, the undersigned officers and directors of CHF Solutions, Inc., hereby constitute John L. Erb and Claudia Drayton, as the true and lawful attorneys with full power to them, and each of them singly to sign for us and
      in our names, in the capacities indicated below the Registration Statement filed herewith and any amendments to said Registration Statement, and generally to do all such things in our name and behalf in our capacities as officers and directors to
      enable CHF Solutions, Inc. to comply with the provisions of the Securities Act of 1933 and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any
      of them, to said Registration Statement and any and all amendments thereto.  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates
      indicated.
SIGNATURE
TITLE
DATE
/s/ J
ohn
L. E
rb
President, CEO and Chairman
August 8, 2019
John L. Erb
(principal executive officer)
/s/
Claudia Drayton
Chief Financial Officer
August 8, 2019
Claudia Drayton
(principal financial and accounting officer)
/s/
Steve Brandt
Director
August 8, 2019
Steve Brandt
/s/
Matthew Likens
Director
August 8, 2019
Matthew Likens
/s/
Jon W. Salveson
Director
August 8, 2019
Jon W. Salveson
/s/
Gregory D. Waller
Director
August 8, 2019
Gregory D. Waller
/s/
Warren S. Watson
Director
August 8, 2019
Warren S. Watson
7