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    <div style="text-align: center; color: #000000;">As filed with the Securities and Exchange Commission on March 28, 2024</div>
    <div style="text-align: right; color: #000000;">Registration No. 333-_________</div>
    <div><br>
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    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;"> <font style="font-size: 10pt;"><br>
      </font></div>
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    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">UNDER</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;">PDS Biotechnology Corporation</div>
    <div style="text-align: center; color: #000000;">(Exact name of registrant as specified in its charter)</div>
    <div><br>
    </div>
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            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
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          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">26-4231384</div>
          </td>
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          <td style="width: 49.01%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(State or other jurisdiction of incorporation or organization)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(I.R.S. Employer Identification No.)</div>
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    <table cellspacing="0" cellpadding="0" border="0" id="z7f6db9752b2748548470995b884c7c4a" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 49.01%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-weight: bold;">303A College Road East</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Princeton, NJ</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">08540</div>
          </td>
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          <td style="width: 49.01%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(Address of Principal Executive Offices)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(Zip Code)</div>
          </td>
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    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">PDS Biotechnology Corporation 2019 Inducement Plan, as amended</div>
    <div style="text-align: center; color: #000000;">(Full title of the plans)</div>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Frank Bedu-Addo, Ph.D.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">President and Chief Executive Officer</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">PDS Biotechnology Corporation</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">303A College Road East</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Princeton, NJ 08540</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(800) 208-3343</div>
    <div style="text-align: center; color: #000000;">(Name, address and telephone number, including area code, of agent for service)</div>
    <div style="text-align: center; color: #000000;"> <br>
    </div>
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      <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div><br>
    </div>
    <div style="color: #000000;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
      filer&#8221; and &#8220;smaller reporting company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div><br>
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          <td style="width: 15%; vertical-align: middle;">&#160;</td>
          <td style="width: 35%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Large Accelerated filer&#8195;&#9744;</div>
          </td>
          <td style="width: 50%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Accelerated filer&#8195;&#9744;</div>
          </td>
        </tr>
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          <td style="width: 15%; vertical-align: top;">&#160;</td>
          <td style="width: 35%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Non-accelerated filer&#8195;&#9746;</div>
          </td>
          <td style="width: 50%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Smaller reporting company&#8195;&#9746;</div>
          </td>
        </tr>
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          <td style="width: 15%; vertical-align: top;">&#160;</td>
          <td style="width: 35%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Emerging growth company&#8195;&#9744;</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="color: #000000;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section
      7(a)(2)(B) of the Securities Act.&#8195;&#9744;</div>
    <div style="color: #000000;"> <br>
    </div>
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    <div style="text-align: center; color: #000000; font-weight: bold;">Part II</div>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Information Required In The Registration Statement</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="color: #000000;">This Registration Statement relates to the registration of an additional 1,000,000 shares (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: #000000;">Shares</font><font style="color: #000000;">&#8221;) of the Registrant&#8217;s Common Stock. The Shares are securities of the same class and relate to the same employee benefit plan, the PDS Biotechnology Corporation 2019 Inducement Plan, which was
        amended effective as of January 22, 2024 (in the form attached hereto as Exhibit 99.1) (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: #000000;">Inducement Plan</font><font style="color: #000000;">&#8221;), as those registered
        pursuant to the Registrant&#8217;s registration statements on Form S-8, previously filed with the Securities and Exchange Commission on </font><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036119020567/forms8.htm">November 14, 2019
        (Registration No. 333-234693)</a><font style="color: #000000;">, </font><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036121037880/brhc10030771_s8.htm">November 15, 2021 (Registration No. 333-261072)</a>, and <a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036122030733/ny20005031x3_s8.htm">August 24, 2022 (Registration No. 333-267042)</a><font style="color: #000000;">.</font></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="color: #000000;">In accordance with General Instruction E of Form S-8, the contents of the Registrant&#8217;s registration statements on Form S-8 filed with the Securities and Exchange
        Commission on </font><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036119020567/forms8.htm">November 14, 2019 (Registration No. 333-234693)</a><font style="color: #000000;">, </font><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036121037880/brhc10030771_s8.htm">November 15, 2021 (Registration No. 333-261072)</a><font style="color: #0000EE;">, </font>and <a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036122030733/ny20005031x3_s8.htm">August 24, 2022 (Registration No. 333-267042)</a><font style="color: #000000;"> are incorporated herein by reference (solely to the extent the contents of
        such registration statement relate to the Inducement Plan) and the information required by Part II is omitted, except as supplemented by the information set forth below.</font></div>
    <div style="text-align: justify;"><font style="color: rgb(0, 0, 0);"> <br>
      </font></div>
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            <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 8.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;">Exhibits.</div>
            </td>
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            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Exhibit</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">No.</div>
          </td>
          <td style="width: 92%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Description</div>
          </td>
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          <td style="width: 8%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000156761915001328/s000911x12_ex3-1.htm">4.1</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission on October 6, 2015).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle;">
            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036119005071/ex3_1.htm">4.2</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission
              on March 18, 2019).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036119005071/ex3_2.htm">4.3</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed with the Commission
              on March 18, 2019).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle;">
            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036122009505/brhc10035198_ex3-1.htm">4.4</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Third Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission on March 15, 2022).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000156761915001209/s000911x5_ex4-1.htm">4.5</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Form of Certificate of Common Stock (incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Pre-Effective Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333- 206416) filed with the
              Commission on September 21, 2015).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle;">
            <div style="text-align: center;"><a href="ef20025023_ex5-1.htm">5.1*</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Opinion of DLA Piper LLP (US).</div>
          </td>
        </tr>
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          <td style="width: 8%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="ef20025023_ex23-1.htm">23.1*</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Consent of KPMG LLP.</div>
          </td>
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        <tr>
          <td style="width: 8%; vertical-align: middle;">
            <div style="text-align: center;"><a href="ef20025023_ex5-1.htm">23.2*</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Consent of DLA Piper LLP (US) (included in Exhibit 5.1).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="#POWEROFATTORNEY">24</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Power of Attorney (contained on the signature page hereto).</div>
          </td>
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          <td style="width: 8%; vertical-align: middle;">
            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036124003165/ef20019392_ex10-1.htm">99.1</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">PDS Biotechnology Corporation 2019 Inducement Plan, as amended (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed with the Commission on January 22, 2024).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="ef20025023_ex107.htm">107*</a></div>
          </td>
          <td style="width: 92%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Filing Fee Table</div>
          </td>
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          <td style="width: 8%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0);">*</div>
          </td>
          <td style="width: 92%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Filed herewith</div>
          </td>
        </tr>

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    <div>&#160;</div>
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    <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURE</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; color: #000000;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
      S-8 and has duly caused this Registration Statement with respect to the PDS Biotechnology Corporation 2019 Inducement Plan, as amended, to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Princeton, State of New
      Jersey, on March 28, 2024.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z32546f6f97bb43e6a52cf2abe0d56f92" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 49.81%; vertical-align: middle;">&#160;</td>
          <td style="vertical-align: middle;" colspan="2">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">PDS Biotechnology Corporation</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.81%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: middle;">&#160;</td>
          <td style="width: 45%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 49.81%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">By:</div>
          </td>
          <td style="width: 45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0);">/s/ Frank Bedu-Addo</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.81%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Name:</div>
          </td>
          <td style="width: 45%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Frank Bedu-Addo</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.81%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">Title:</div>
          </td>
          <td style="width: 45%; vertical-align: middle;">
            <div style="color: rgb(0, 0, 0);">President and Chief Executive Officer</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <a name="POWEROFATTORNEY"><!--Anchor--></a>
    <div style="text-align: center; color: #000000; font-weight: bold;">POWER OF ATTORNEY</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; color: #000000;">The officers and directors of PDS Biotechnology Corporation whose signatures appear below hereby constitute and appoint Frank Bedu-Addo and Lars Boesgaard, and each of them, their
      true and lawful attorneys and agents, with full power of substitution, each with power to act alone, to sign and execute on behalf of the undersigned this Registration Statement on Form S-8 with respect to the PDS Biotechnology Corporation 2019
      Inducement Plan, as amended, and any amendment or amendments thereto, and each of the undersigned does hereby ratify and confirm all that each attorney and agent, or his or her substitutes, shall do or cause to be done by virtue hereof.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; color: #000000;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="zae5d968a5d364f8c9f9b3c2e6709f403" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 28%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Signature</div>
          </td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 40%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Title</div>
          </td>
          <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
          <td style="width: 27.64%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Date</div>
          </td>
        </tr>
        <tr>
          <td style="width: 28%; vertical-align: middle;">&#160;</td>
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[{"type": "S-8", "sequence": "1", "filename": "ef20025023_s8.htm", "description": "S-8", "secsgml_size_bytes": 37545}]
{"company-data": {"conformed-name": "PDS Biotechnology Corp", "cik": "0001472091", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "irs-number": "264231384", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-278355", "film-number": "24800602"}, "business-address": {"street1": "303A COLLEGE ROAD EAST", "city": "PRINCETON", "state": "NJ", "zip": "08540", "phone": "800-208-3343"}, "mail-address": {"street1": "303A COLLEGE ROAD EAST", "city": "PRINCETON", "state": "NJ", "zip": "08540"}, "former-company": {"former-conformed-name": "Edge Therapeutics, Inc.", "date-changed": "20090911"}}
As filed with the Securities and Exchange Commission on March 28, 2024
Registration No. 333-_________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
PDS Biotechnology Corporation
(Exact name of registrant as specified in its charter)
Delaware
26-4231384
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
303A College Road East
Princeton, NJ
08540
(Address of Principal Executive Offices)
(Zip Code)
PDS Biotechnology Corporation 2019 Inducement Plan, as amended
(Full title of the plans)
Frank Bedu-Addo, Ph.D.
President and Chief Executive Officer
PDS Biotechnology Corporation
303A College Road East
Princeton, NJ 08540
(800) 208-3343
(Name, address and telephone number, including area code, of agent for service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated
      filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act.
Large Accelerated filer ☐
Accelerated filer ☐
Non-accelerated filer ☒
Smaller reporting company ☒
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section
      7(a)(2)(B) of the Securities Act. ☐
Part II
Information Required In The Registration Statement
This Registration Statement relates to the registration of an additional 1,000,000 shares (the "
Shares
") of the Registrant's Common Stock. The Shares are securities of the same class and relate to the same employee benefit plan, the PDS Biotechnology Corporation 2019 Inducement Plan, which was
        amended effective as of January 22, 2024 (in the form attached hereto as Exhibit 99.1) (the "
Inducement Plan
"), as those registered
        pursuant to the Registrant's registration statements on Form S-8, previously filed with the Securities and Exchange Commission on
November 14, 2019
        (Registration No. 333-234693)
,
November 15, 2021 (Registration No. 333-261072)
, and
August 24, 2022 (Registration No. 333-267042)
.
In accordance with General Instruction E of Form S-8, the contents of the Registrant's registration statements on Form S-8 filed with the Securities and Exchange
        Commission on
November 14, 2019 (Registration No. 333-234693)
,
November 15, 2021 (Registration No. 333-261072)
,
and
August 24, 2022 (Registration No. 333-267042)
are incorporated herein by reference (solely to the extent the contents of
        such registration statement relate to the Inducement Plan) and the information required by Part II is omitted, except as supplemented by the information set forth below.
Item 8.
Exhibits.
Exhibit
No.
Description
4.1
Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission on October 6, 2015).
4.2
Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission
              on March 18, 2019).
4.3
Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed with the Commission
              on March 18, 2019).
4.4
Third Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission on March 15, 2022).
4.5
Form of Certificate of Common Stock (incorporated by reference to Exhibit 4.1 to the Registrant's Pre-Effective Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333- 206416) filed with the
              Commission on September 21, 2015).
5.1*
Opinion of DLA Piper LLP (US).
23.1*
Consent of KPMG LLP.
23.2*
Consent of DLA Piper LLP (US) (included in Exhibit 5.1).
24
Power of Attorney (contained on the signature page hereto).
99.1
PDS Biotechnology Corporation 2019 Inducement Plan, as amended (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed with the Commission on January 22, 2024).
107*
Filing Fee Table
*
Filed herewith
SIGNATURE
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
      S-8 and has duly caused this Registration Statement with respect to the PDS Biotechnology Corporation 2019 Inducement Plan, as amended, to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Princeton, State of New
      Jersey, on March 28, 2024.
PDS Biotechnology Corporation
By:
/s/ Frank Bedu-Addo
Name:
Frank Bedu-Addo
Title:
President and Chief Executive Officer
POWER OF ATTORNEY
The officers and directors of PDS Biotechnology Corporation whose signatures appear below hereby constitute and appoint Frank Bedu-Addo and Lars Boesgaard, and each of them, their
      true and lawful attorneys and agents, with full power of substitution, each with power to act alone, to sign and execute on behalf of the undersigned this Registration Statement on Form S-8 with respect to the PDS Biotechnology Corporation 2019
      Inducement Plan, as amended, and any amendment or amendments thereto, and each of the undersigned does hereby ratify and confirm all that each attorney and agent, or his or her substitutes, shall do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.
Signature
Title
Date
/s/ Frank Bedu-Addo
President, Chief Executive Officer and Director
March 28, 2024
Frank Bedu-Addo
(Principal Executive Officer)
/s/ Lars Boesgaard
Chief Financial Officer
March 28, 2024
Lars Boesgaard
(Principal Financial and Accounting Officer)
/s/ Stephen Glover
Director
March 28, 2024
Stephen Glover
/s/ Kamil Ali-Jackson
Director
March 28, 2024
Kamil Ali-Jackson
/s/ Otis W. Brawley
Director
March 28, 2024
Otis W. Brawley
/s/ Gregory Freitag
Director
March 28, 2024
Gregory Freitag
/s/ Ilian Iliev
Director
March 28, 2024
Ilian Iliev
/s/ Richard Sykes
Director
March 28, 2024
Sir Richard Sykes