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    <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on February 27, 2025</div>
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      <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
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    <div style="text-align: center; font-weight: bold;"> <br>
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    <div style="text-align: center; font-weight: bold; font-size: 14pt;">UNITED STATES</div>
    <font style="font-size: 14pt;"> </font>
    <div style="text-align: center; font-weight: bold; font-size: 14pt;">SECURITIES AND EXCHANGE COMMISSION</div>
    <font style="font-size: 12pt;"> </font>
    <div style="text-align: center; font-weight: bold; font-size: 12pt;">Washington, D.C.&#160; 20549</div>
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    <div style="text-align: center; font-weight: bold; font-size: 18pt;">FORM S-8</div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-weight: bold;">UNDER THE SECURITIES ACT OF 1933</div>
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      <div><font style="font-weight: normal;">&#160;<br>
        </font> </div>
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      <div><font style="font-weight: normal;">&#160;</font><br>
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    <div style="text-align: center; font-weight: bold; font-size: 24pt;">GH Research PLC</div>
    <div style="text-align: center; font-weight: bold;">(Exact Name of Registrant as specified in its charter)</div>
    <div style="text-align: center; font-weight: bold;"> <br>
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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Ireland</div>
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          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">N/A</div>
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          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">(State or other jurisdiction of</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">incorporation or organization)</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">(I.R.S. Employer</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Identification No.)</div>
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          <td style="width: 29%; vertical-align: top;">&#160;</td>
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              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">GH Research PLC</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Joshua Dawson House</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Dawson Street</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Dublin 2</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">D02 RY95</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Ireland</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Tel: +353 1 437 8334</div>
            </div>
          </td>
          <td style="width: 31.12%; vertical-align: top;">&#160;</td>
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          <td colspan="3" style="vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">(Address, including zip code, and telephone number, including area code, of Principal Executive Offices)</div>
          </td>
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          <td colspan="3" style="vertical-align: top;">
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">GH Research PLC Share Option Plan</div>
          </td>
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          <td style="width: 29%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: middle;">
            <div style="text-align: center; margin-left: 36pt; font-family: 'Times New Roman', Times, serif;">(Full title of the plan)</div>
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          <td style="width: 31.12%; vertical-align: top;">&#160;</td>
        </tr>

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              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Cogency Global Inc.</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">122 East 42<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup> Street, 18<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">New York, NY 10168</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Tel: (800) 221-0102</div>
            </div>
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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
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          <td style="width: 29%; vertical-align: top;">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; text-align: center;"><font style="font-weight: bold;">Copies to</font>:</div>
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          <td style="width: 29%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Adam Kaminsky</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Davis Polk &amp; Wardwell LLP</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">450 Lexington Avenue</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">New York, NY 10017</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">(212) 450-4000</div>
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    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the
      definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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            <td style="width: 70.16%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Large accelerated filer<font style="font-weight: normal;"> &#9744;</font></div>
            </td>
            <td style="width: 29.84%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Accelerated filer<font style="font-weight: normal;"> &#9746;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 70.16%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Non-accelerated filer<font style="font-weight: normal;"> &#9744;</font> (Do not check if a smaller reporting company)</div>
            </td>
            <td style="width: 29.84%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Smaller reporting company<font style="font-weight: normal;"> &#9744;</font></div>
            </td>
          </tr>

      </table>
    </div>
    &#160;
    <div style="text-align: center; margin-left: 27.5pt; font-weight: bold;">Emerging Growth Company<font style="font-weight: normal;"> &#9746;</font></div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
      provided pursuant to Section 7(a)(2)(B) of the Securities Act.<font style="font-weight: normal;"> &#9744;</font></div>
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    <div style="text-align: center; text-indent: 18pt; font-weight: bold;">PART I</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION OF ADDITIONAL SECURITIES PURSUANT TO GENERAL INSTRUCTION</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">Pursuant to General Instruction E to Form S-8, GH Research PLC (the &#8220;Registrant&#8221;) is filing this Registration Statement on Form S-8 (this &#8220;Registration Statement&#8221;) with the U.S. Securities and
      Exchange Commission (the &#8220;Commission&#8221;) to register 999,970 additional ordinary shares, nominal value $0.025 per share, for issuance under the GH Research PLC Share Option Plan, as amended November 24, 2024. This Registration Statement hereby
      incorporates by reference the contents of the Registrant&#8217;s registration statement on Form S-8 filed with the Commission on March 9, 2023 (Registration No. 333-270422).</div>
    <div><br>
    </div>
    <div style="text-align: center; text-indent: 18pt; font-weight: bold;">PART II</div>
    <div><br>
    </div>
    <div style="text-align: center; text-indent: 18pt; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div><br>
    </div>
    <div style="text-align: justify; font-weight: bold;">Item 3.&#160; Incorporation of Documents by Reference.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">The following documents are incorporated herein by reference:</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">(a) The annual report on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1855129/000114036125006175/ef20039003_20f.htm">Form 20-F</a> of GH Research PLC (the &#8220;Registrant&#8221;) for the fiscal
      year ended December 31, 2024, filed with the Commission on February 27, 2025; and</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">(b) The description of the Registrant&#8217;s share capital which is contained in the Registrant&#8217;s Registration Statement on <a href="https://www.sec.gov/Archives/edgar/data/1855129/000114036121021842/nt10022430x7_8a12b.htm">Form 8-A</a> (Registration No. 001-40530), dated June 22, 2021, including any amendments or supplements thereto.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">In addition, all documents subsequently filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
      amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, including any Reports of Foreign Private Issuers on Form 6-K submitted during such period
      (or portion thereof) that is identified in such form as being incorporated by reference into this Registration Statement, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the
      filing of such documents. The Registrant is not incorporating by reference any documents or portions thereof, whether specifically listed above or filed in the future, that are not deemed &#8220;filed&#8221; with the Commission.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the
      extent that a statement contained herein, (or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement so modified or superseded
      shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</div>
    <div><br>
    </div>
    <div style="text-align: justify; font-weight: bold;">Item 8.&#160; Exhibits.</div>
    <div style="text-align: justify; font-weight: bold;"> <br>
    </div>
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            <div>
              <div style="text-align: justify;">Exhibit</div>
              <div style="text-align: justify;">Number</div>
            </div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 90%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        </tr>
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          <td style="width: 9%; vertical-align: top;">
            <div style="text-align: justify;">4</div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">
            <div>Constitution of GH Research PLC (incorporated herein by reference to <a href="https://www.sec.gov/Archives/edgar/data/1855129/000114036123010814/brhc10049341_ex1-1.htm">Exhibit 1.1</a> of the Registrant&#8217;s Annual Report on Form 20-F for
              the fiscal year ended December 31, 2022, filed with the Commission on March 9, 2023).</div>
            <div> <br>
            </div>
          </td>
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          <td style="width: 9%; vertical-align: top;">
            <div style="text-align: justify;"><a href="ny20044079x2_ex5.htm">5</a></div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">
            <div>Opinion of A&amp;L Goodbody LLP (filed herewith)</div>
            <div> <br>
            </div>
          </td>
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          <td style="width: 9%; vertical-align: top;">
            <div style="text-align: justify;"><a href="ny20044079x2_ex5.htm">23.1</a></div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">
            <div>Consent of A&amp;L Goodbody LLP (included in Exhibit 5)</div>
            <div> <br>
            </div>
          </td>
        </tr>
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          <td style="width: 9%; vertical-align: top;">
            <div style="text-align: justify;"><a href="ny20044079x2_ex23-2.htm">23.2</a></div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">
            <div>Consent of PricewaterhouseCoopers an independent registered public accounting firm (filed herewith)</div>
            <div> <br>
            </div>
          </td>
        </tr>
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          <td style="width: 9%; vertical-align: top;">
            <div style="text-align: justify;"><a href="#POWEROFATTORNEY">24</a></div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">
            <div>Powers of Attorney (included in the signature pages hereto)</div>
            <div> <br>
            </div>
          </td>
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          <td style="width: 9%; vertical-align: top;">
            <div style="text-align: justify;">99</div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">
            <div>GH Research PLC Share Option Plan, as amended November 24, 2024 (incorporated by reference to <a href="https://www.sec.gov/Archives/edgar/data/1855129/000114036125006175/ef20039003_ex4-1.htm">Exhibit 4.1</a> of the Registrant&#8217;s Annual
              Report on Form 20-F for the fiscal year ended December 31, 2024, filed with the Commission on February 27, 2025)</div>
            <div> <br>
            </div>
          </td>
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          <td style="width: 9%; vertical-align: top;">
            <div style="text-align: justify;"><a href="ny20044079x2_ex107.htm">107</a></div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">
            <div>Filing Fee Table</div>
          </td>
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    <div style="text-align: center; font-weight: bold;"><a name="SIGNATURES"><!--Anchor--></a>SIGNATURES</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 18pt;">Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this Registration Statement and
      has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Dublin, Ireland, on this 27<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> day of
      February, 2025.</div>
    <div style="text-align: justify; text-indent: 18pt;"> <br>
    </div>
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          <td colspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
          <td colspan="2" style="vertical-align: top;">
            <div style="text-align: justify;">GH Research PLC</div>
            <div style="text-align: justify;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="text-align: justify;">By:</div>
          </td>
          <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Julie Ryan <br>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="text-align: justify;">Name:</div>
          </td>
          <td style="width: 45%; vertical-align: top;">
            <div style="text-align: justify; color: #000000;">Julie Ryan</div>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">
            <div style="text-align: justify;">Title:</div>
          </td>
          <td style="width: 45%; vertical-align: top;">
            <div style="text-align: justify;">Vice President, Finance</div>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 45%; vertical-align: top;">&#160;</td>
        </tr>

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    <div style="text-align: center; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
    <div><br>
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      <div style="text-align: justify; text-indent: 42.85pt; color: #000000;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Velichka Valcheva and Julie Ryan, either of whom may act without the
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        (including post-effective amendments) to this Registration Statement and any and all additional registration statements pursuant to Rule 462(b) of the Securities Act and to file the same, with all exhibits thereto, and all other documents in
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      <div style="text-align: justify; text-indent: 42.85pt; color: #000000;">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</div>
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            <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">February 27, 2025</div>
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          <td style="width: 33%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
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            <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">February 27, 2025</div>
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          <td style="width: 33%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
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            <div>/s/ Florian Sch&#246;nharting&#160; </div>
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          <td style="width: 32%; vertical-align: bottom; padding-bottom: 2px;">
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          <td style="width: 33%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">February 27, 2025</div>
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          <td style="width: 33%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
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            <div>/s/ Michael Forer&#160; </div>
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          <td style="width: 1.74%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 32%; vertical-align: bottom; padding-bottom: 2px;">
            <div>Director</div>
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          <td style="width: 33%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">February 27, 2025</div>
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          <td style="width: 1.74%; vertical-align: top;">&#160;</td>
          <td style="width: 32%; vertical-align: bottom;">&#160;</td>
          <td style="width: 33%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 33%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>&#160;</div>
            <div>/s/ Dermot Hanley&#160; </div>
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          <td style="width: 1.74%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 32%; vertical-align: bottom; padding-bottom: 2px;">
            <div>Director</div>
          </td>
          <td style="width: 33%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">February 27, 2025</div>
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          <td style="width: 33%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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            <div>/s/ Duncan Moore&#160; </div>
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            <div>Director</div>
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            <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">February 27, 2025</div>
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        <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
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    <div style="text-align: center; font-weight: bold;"><a name="SIGNATUREOFAUTHORIZEDREPR"><!--Anchor--></a>SIGNATURE OF AUTHORIZED REPRESENTATIVE IN THE UNITED STATES</div>
    <div>
      <div><br>
      </div>
      <div style="text-align: justify; text-indent: 42.85pt; color: #000000;">Pursuant to the Securities Act of 1933, as amended, the undersigned, the duly authorized representative in the United States of America, has signed this registration statement
        thereto in New York, NY on February 27, 2025.</div>
      <div style="text-align: justify; text-indent: 42.85pt; color: #000000;"> <br>
      </div>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

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            <div>
              <div style="text-align: justify; color: #000000; font-weight: bold;">Authorized U.S. Representative--Cogency Global Inc.</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: bottom; width: 5%;">&#160;</td>
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              </div>
            </div>
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          <td style="width: 45%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Colleen A. De Vries <br>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: bottom; width: 5%;">&#160;</td>
          <td style="width: 45%; vertical-align: bottom;">
            <div>
              <div style="text-align: justify; color: #000000;">Name: Colleen A. De Vries</div>
            </div>
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        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: bottom; width: 5%;"><br>
          </td>
          <td style="width: 45%; vertical-align: bottom;">
            <div>
              <div style="text-align: justify; color: #000000;">Title: Senior Vice-President on behalf of</div>
            </div>
          </td>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: bottom; width: 5%;"><br>
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              <div style="text-align: justify; color: #000000;">Cogency Global Inc.</div>
            </div>
          </td>
        </tr>

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{"company-data": {"conformed-name": "GH Research PLC", "cik": "0001855129", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "irs-number": "000000000", "state-of-incorporation": "L2", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-285311", "film-number": "25673196"}, "business-address": {"street1": "JOSHUA DAWSON HOUSE", "street2": "DAWSON STREET", "city": "DUBLIN 2", "state": "L2", "zip": "D02 RY95", "phone": "353 1 437 8334"}, "mail-address": {"street1": "JOSHUA DAWSON HOUSE", "street2": "DAWSON STREET", "city": "DUBLIN 2", "state": "L2", "zip": "D02 RY95"}}
As filed with the Securities and Exchange Commission on February 27, 2025
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
FORM S-8
REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OF 1933
GH Research PLC
(Exact Name of Registrant as specified in its charter)
Ireland
N/A
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
GH Research PLC
Joshua Dawson House
Dawson Street
Dublin 2
D02 RY95
Ireland
Tel: +353 1 437 8334
(Address, including zip code, and telephone number, including area code, of Principal Executive Offices)
GH Research PLC Share Option Plan
(Full title of the plan)
Cogency Global Inc.
122 East 42
nd
Street, 18
th
Floor
New York, NY 10168
Tel: (800) 221-0102
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to
:
Adam Kaminsky
Davis Polk & Wardwell LLP
450 Lexington Avenue
New York, NY 10017
(212) 450-4000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the
      definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☒
Non-accelerated filer
☐
(Do not check if a smaller reporting company)
Smaller reporting company
☐
Emerging Growth Company
☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
      provided pursuant to Section 7(a)(2)(B) of the Securities Act.
☐
PART I
REGISTRATION OF ADDITIONAL SECURITIES PURSUANT TO GENERAL INSTRUCTION
Pursuant to General Instruction E to Form S-8, GH Research PLC (the "Registrant") is filing this Registration Statement on Form S-8 (this "Registration Statement") with the U.S. Securities and
      Exchange Commission (the "Commission") to register 999,970 additional ordinary shares, nominal value $0.025 per share, for issuance under the GH Research PLC Share Option Plan, as amended November 24, 2024. This Registration Statement hereby
      incorporates by reference the contents of the Registrant's registration statement on Form S-8 filed with the Commission on March 9, 2023 (Registration No. 333-270422).
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.  Incorporation of Documents by Reference.
The following documents are incorporated herein by reference:
(a) The annual report on
Form 20-F
of GH Research PLC (the "Registrant") for the fiscal
      year ended December 31, 2024, filed with the Commission on February 27, 2025; and
(b) The description of the Registrant's share capital which is contained in the Registrant's Registration Statement on
Form 8-A
(Registration No. 001-40530), dated June 22, 2021, including any amendments or supplements thereto.
In addition, all documents subsequently filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
      amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, including any Reports of Foreign Private Issuers on Form 6-K submitted during such period
      (or portion thereof) that is identified in such form as being incorporated by reference into this Registration Statement, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the
      filing of such documents. The Registrant is not incorporating by reference any documents or portions thereof, whether specifically listed above or filed in the future, that are not deemed "filed" with the Commission.
Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the
      extent that a statement contained herein, (or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement so modified or superseded
      shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 8.  Exhibits.
Exhibit
Number
4
Constitution of GH Research PLC (incorporated herein by reference to
Exhibit 1.1
of the Registrant's Annual Report on Form 20-F for
              the fiscal year ended December 31, 2022, filed with the Commission on March 9, 2023).
5
Opinion of A&L Goodbody LLP (filed herewith)
23.1
Consent of A&L Goodbody LLP (included in Exhibit 5)
23.2
Consent of PricewaterhouseCoopers an independent registered public accounting firm (filed herewith)
24
Powers of Attorney (included in the signature pages hereto)
99
GH Research PLC Share Option Plan, as amended November 24, 2024 (incorporated by reference to
Exhibit 4.1
of the Registrant's Annual
              Report on Form 20-F for the fiscal year ended December 31, 2024, filed with the Commission on February 27, 2025)
107
Filing Fee Table
SIGNATURES
Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this Registration Statement and
      has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Dublin, Ireland, on this 27
th
day of
      February, 2025.
GH Research PLC
By:
/s/ Julie Ryan
Name:
Julie Ryan
Title:
Vice President, Finance
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Velichka Valcheva and Julie Ryan, either of whom may act without the
        joinder of the other, as his or her true and lawful attorneys-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments
        (including post-effective amendments) to this Registration Statement and any and all additional registration statements pursuant to Rule 462(b) of the Securities Act and to file the same, with all exhibits thereto, and all other documents in
        connection therewith, with the Commission, granting unto said attorneys-in-fact and agent full power and authority to do and perform each and every act in person, hereby ratifying and confirming all that said attorney-in-fact and agent or his
        substitutes may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Velichka Valcheva
Chief Executive Officer
February 27, 2025
Velichka Valcheva
(Principal Executive Officer)
/s/ Julie Ryan
Vice President, Finance
February 27, 2025
Julie Ryan
(Principal Financial Officer and Principal Accounting Officer)
/s/ Florian Schönharting
Director
February 27, 2025
Florian Sch
ön
harting
/s/ Michael Forer
Director
February 27, 2025
Michael Forer
/s/ Dermot Hanley
Director
February 27, 2025
Dermot Hanley
/s/ Duncan Moore
Director
February 27, 2025
Duncan Moore
SIGNATURE OF AUTHORIZED REPRESENTATIVE IN THE UNITED STATES
Pursuant to the Securities Act of 1933, as amended, the undersigned, the duly authorized representative in the United States of America, has signed this registration statement
        thereto in New York, NY on February 27, 2025.
Authorized U.S. Representative--Cogency Global Inc.
By:
/s/ Colleen A. De Vries
Name: Colleen A. De Vries
Title: Senior Vice-President on behalf of
Cogency Global Inc.