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    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">As filed with the Securities and Exchange Commission on April 5, 2022</div>
    <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">Registration No. 333-</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">UNDER</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-variant: small-caps; font-weight: bold;">Ocuphire Pharma, Inc.</div>
    <div style="text-align: center; margin-left: 1.8pt; color: rgb(0, 0, 0);">(Exact name of registrant as specified in its charter)</div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z44cda592c92047e4bfff1dfe0565a938">

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          <td style="width: 22%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">&#160;</td>
          <td style="width: 22%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">11-3516358</div>
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          <td style="width: 22%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(State or other jurisdiction of</div>
            <div style="text-align: center; color: rgb(0, 0, 0);">incorporation or organization)</div>
          </td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
          <td style="width: 22%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(I.R.S. Employer Identification No.)</div>
          </td>
          <td style="width: 23%; vertical-align: top;">&#160;</td>
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          <td style="width: 23%; vertical-align: top;">&#160;</td>
          <td style="width: 22%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">37000 Grand River </div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Avenue, Suite 120</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Farmington Hills, MI</div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">&#160;</td>
          <td style="width: 22%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">48335</div>
          </td>
          <td style="width: 23%; vertical-align: top;">&#160;</td>
        </tr>
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          <td style="width: 23%; vertical-align: top;">&#160;</td>
          <td style="width: 22%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(Address of principal executive offices)</div>
          </td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
          <td style="width: 22%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(Zip code)</div>
          </td>
          <td style="width: 23%; vertical-align: top;">&#160;</td>
        </tr>

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    <div><br>
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    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Ocuphire Pharma, Inc. 2020 Equity Incentive Plan</div>
          </td>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(Full title of the plan)</div>
          </td>
        </tr>
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          <td style="width: 100%; vertical-align: middle; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Mina Sooch</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">President and Chief Executive Officer</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Ocuphire Pharma, Inc.</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">37000 Grand River Avenue, Suite 120</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Farmington Hills, MI 48335</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(248) 681-9815</div>
          </td>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(Name, address, and telephone number, including area code, of agent for service)</div>
          </td>
        </tr>

    </table>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Copy to:</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Phillip D. Torrence, Esq.</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Emily J. Johns, Esq.</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Honigman LLP</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">650 Trade Center Way, Suite 200</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Kalamazoo, Michigan 49002-0402</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(269) 337-7700</div>
    <div style="color: rgb(0, 0, 0);">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large
      accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div style="text-align: center; color: rgb(0, 0, 0);">Large accelerated filer &#9744; Accelerated filer &#9744;</div>
    <div style="text-align: center; color: rgb(0, 0, 0);">Non-accelerated filer &#9746; Smaller reporting company &#9746;</div>
    <div style="text-align: center; color: rgb(0, 0, 0);">Emerging growth company &#9744;</div>
    <div style="color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
      Section 7(a)(2)(B) of the Securities Act. &#9746;</div>
    <div><br>
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    <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">This Registration Statement on Form S-8 is being filed by Ocuphire Pharma, Inc. (the &#8220;<font style="font-weight: bold; font-style: italic;">Company</font>&#8221; or &#8220;Registrant&#8221; for the purpose of
      registering an additional 942,291 shares of Common Stock issuable pursuant to the Ocuphire Pharma, Inc. 2020 Equity Incentive Plan (the &#8220;<font style="font-weight: bold; font-style: italic;">Equity Incentive Plan</font>&#8221;).</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Pursuant to General Instruction E to Form S-8, this Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a
      Registration Statement of the Company on Form S-8 relating to the Equity Incentive Plan is effective, and the Company&#8217;s Registration Statements on Form S-8 previously filed with the Securities and Exchange Commission (the &#8220;<font style="font-weight: bold; font-style: italic;">Commission</font>&#8221;) on November 9, 2020 (File No. 333-249978) and March 31, 2021 (File No. 333-254923) registering shares of Common Stock issuable under the Equity Incentive Plan are incorporated by reference in this
      Registration Statement.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">PART II</div>
    <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div>&#160;</div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="z83819a7e79644bb6b3d05dafdf3cfab1" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;">

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            <td style="vertical-align: top; width: 36pt;"> <font style="font-weight: bold;">Item 3.</font> </td>
            <td style="align: left; vertical-align: top; width: auto;"> <font style="font-weight: bold;">Incorporation of Documents By Reference.</font> </td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:</div>
    <div>&#160;</div>
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          <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(a)</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-family: 'Times New Roman', Times, serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">the Registrant&#8217;s Annual Report on Form 10-K filed on </font><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036122011015/brhc10035368_10k.htm"><font style="font-family: 'Times New Roman';">March 24, 2022</font></a><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">;</font></div>
          </td>
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    </table>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="za10d73ecda7e430689a103598fa412db">

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          </td>
          <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(b)</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-family: 'Times New Roman', Times, serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">the Registrant&#8217;s Current Reports on Form 8-K filed on </font><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036122003200/brhc10033300_8k.htm"><font style="font-family: 'Times New Roman';">January 31, 2022</font></a> and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001228627/000114036122011507/brhc10035817_8k.htm">March 29, 2022</a><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">; and</font></div>
          </td>
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    </table>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z892bf647bd514f43bd13a2ae8e8867b9">

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          </td>
          <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(c)</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-family: 'Times New Roman', Times, serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">the description of the Company&#8217;s Common Stock contained in the Company&#8217;s Form 8-A (File No. 001-34079), as filed with
                the Commission pursuant to Sections 12(b) and 12(g) of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), on </font><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036108013486/form8a12b.htm"><font style="font-family: 'Times New Roman';">May 23, 2008</font></a><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">.</font></div>
          </td>
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    </table>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">In addition, all documents the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the filing of this Registration Statement and prior to the filing
      of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities covered hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part
      hereof from the date of filing of such documents. Notwithstanding anything herein, the Registrant is not incorporating by reference any information furnished under Item 2.02 or Item 7.01 of any Current Report on Form 8-K, unless, and to the extent,
      specified in any such Current Report on Form 8-K.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Any statement herein or contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement
      to the extent that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated by reference herein, modifies or supersedes such prior statement. Any such statement so modified or superseded shall
      not be deemed, except as so modified or superseded, to constitute part of this Registration Statement.</div>
    <div>&#160;</div>
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            <td style="vertical-align: top; width: 36pt;"> <font style="font-weight: bold;">Item 8.</font> </td>
            <td style="align: left; vertical-align: top; width: auto;"> <font style="font-weight: bold;">Exhibits.</font> </td>
          </tr>

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    </div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">INDEX TO EXHIBITS</div>
    <div>&#160;
      <table cellspacing="0" cellpadding="0" id="z869ade2ee88f48ce9aaaa5107ab8be2a" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 9%; vertical-align: top; border-bottom: #000000 2px solid;">
              <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Exhibit</div>
              <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Number</div>
            </td>
            <td style="width: 1%; vertical-align: top; border-bottom: #000000 2px solid;">&#160;</td>
            <td style="width: 90%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
              <div style="color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-weight: bold;">Description</div>
            </td>
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            <td style="width: 9%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: center; color: #0000EE; font-family: 'Times New Roman', Times, serif;"><a href="https://www.sec.gov/Archives/edgar/data/1228627/000089383805000094/corpdefm14a.txt">4.1</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Amended and Restated Certificate of Incorporation (incorporated by reference to Appendix G to the Company&#8217;s Definitive Proxy Statement on Schedule
                14A filed on April 29, 2005)</div>
            </td>
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          <tr>
            <td style="width: 9%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 90%; vertical-align: top;">&#160;</td>
          </tr>
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            <td style="width: 9%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: center; color: #0000EE; font-family: 'Times New Roman', Times, serif;"><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036117018620/ex3_1.htm">4.2</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current
                Report on Form 8-K, filed on May 5, 2017)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 90%; vertical-align: top;">&#160;</td>
          </tr>
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            <td style="width: 9%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: center; color: #0000EE; font-family: 'Times New Roman', Times, serif;"><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036118037339/ex3_1.htm">4.3</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current
                Report on Form 8-K, filed on August 30, 2018)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 90%; vertical-align: top;">&#160;</td>
          </tr>
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            <td style="width: 9%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: center; color: #0000EE; font-family: 'Times New Roman', Times, serif;"><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036119006977/ex3_1.htm">4.4</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current
                Report on Form 8-K, filed on April 12, 2019).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 90%; vertical-align: top;">&#160;</td>
          </tr>
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            <td style="width: 9%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: center; color: #0000EE; font-family: 'Times New Roman', Times, serif;"><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036120024749/brhc10016678_ex3-1.htm">4.5</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current
                Report on Form 8-K, filed on November 6, 2020)</div>
            </td>
          </tr>
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            <td style="width: 9%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 90%; vertical-align: top;">&#160;</td>
          </tr>
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            <td style="width: 9%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: center; color: #0000EE; font-family: 'Times New Roman', Times, serif;"><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036120024749/brhc10016678_ex3-2.htm">4.6</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.2 to the Company&#8217;s Current
                Report on Form 8-K, filed on November 6, 2020)</div>
            </td>
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            <td style="width: 9%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 90%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 9%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: center; color: #0000EE; font-family: 'Times New Roman', Times, serif;"><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036120024749/brhc10016678_ex3-3.htm">4.7</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Company&#8217;s Current Report on Form 8-K, filed
                on November 6, 2020)</div>
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          <tr>
            <td style="width: 9%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 90%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 9%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: center; color: #0000EE; font-family: 'Times New Roman', Times, serif;"><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036120021938/nt10013045x9_s4a.htm">4.8</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Ocuphire Pharma, Inc. 2020 Equity Incentive Plan (incorporated by reference to Annex D to the Company&#8217;s Registration Statement on Form S-4, filed
                on September 30, 2020)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 90%; vertical-align: top;">&#160;</td>
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          <tr>
            <td style="width: 9%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: center; color: #0000EE; font-family: 'Times New Roman', Times, serif;"><a href="brhc10035805_ex5-1.htm">5.1</a></div>
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            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Opinion of Honigman LLP</div>
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            <td style="width: 9%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 90%; vertical-align: top;">&#160;</td>
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          <tr>
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              <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;"><a href="brhc10035805_ex23-1.htm">23.1</a></div>
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            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Consent of Ernst &amp; Young LLP</div>
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            <td style="width: 9%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 90%; vertical-align: top;">&#160;</td>
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          <tr>
            <td rowspan="1" style="width: 9%; vertical-align: top; text-align: center; background-color: rgb(204, 238, 255);"><a href="brhc10035805_ex5-1.htm">23.2</a><br>
            </td>
            <td rowspan="1" style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
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              <div style="font-family: 'Times New Roman', Times, serif;">Consent of Honigman LLP (included in Exhibit 5.1)</div>
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            <td rowspan="1" style="width: 9%; vertical-align: top;">&#160;</td>
            <td rowspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
            <td rowspan="1" style="width: 90%; vertical-align: top;">&#160;</td>
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          <tr>
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              <div style="text-align: center; color: #0000EE; font-family: 'Times New Roman', Times, serif;"><a href="#POWEROFAT">24.1</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Power of Attorney (included after the signature of the Registrant contained on Signature Page of this Registration Statement)</div>
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          <tr>
            <td style="width: 9%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 90%; vertical-align: top;" rowspan="1">&#160;</td>
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          <tr>
            <td style="width: 9%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;"><a href="brhc10035805_ex107.htm">107</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
            <td style="width: 90%; vertical-align: top; background-color: #CCEEFF;">
              <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;">Filing Fee Table</div>
            </td>
          </tr>

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    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
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    <div>&#160;</div>
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        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
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            <div style="color: rgb(0, 0, 0);">OCUPHIRE PHARMA, INC.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 3%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 42%; vertical-align: top;">&#160;</td>
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          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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            <div style="color: rgb(0, 0, 0);">By:</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0); margin-left: 9pt;">/s/ Mina Sooch</div>
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        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 3%; vertical-align: top;">&#160;</td>
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            <div style="color: rgb(0, 0, 0);">Name:</div>
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          <td style="width: 42%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Mina Sooch</div>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 3%; vertical-align: top;">&#160;</td>
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            <div style="color: rgb(0, 0, 0);">Title:</div>
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          <td style="width: 42%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">President and Chief Executive Officer</div>
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        <div style="text-align: center; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a><a name="POWEROFAT"><!--Anchor--></a>POWER OF ATTORNEY</div>
        <div>&#160;</div>
        <div style="text-align: justify; text-indent: 36pt;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Mina Sooch, Bernhard Hoffmann and Amy Rabourn as his or her true and lawful
          attorneys-in-fact and agents with full power of substitution, severally, for him in any and all capacities, to sign the Registration Statement on Form S-8 of Ocuphire Pharma, Inc., and any or all amendments (including post-effective amendments
          thereto), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each
          and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or
          their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</div>
        <div>&#160;</div>
        <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.</div>
        <div>&#160;</div>
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

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              <td style="width: 39.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">SIGNATURE</div>
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              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">DATE</div>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;"><br>
              </td>
              <td style="width: 2%; vertical-align: top;"><br>
              </td>
              <td style="width: 39%; vertical-align: top;"><br>
              </td>
              <td style="width: 2%; vertical-align: top;"><br>
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              <td style="width: 18.44%; vertical-align: top;"><br>
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              <td style="width: 39.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Mina Sooch</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;"><br>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Mina Sooch</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">President, Chief Executive Officer &amp; Director</div>
                <div style="text-align: center; color: rgb(0, 0, 0);">(Principal Executive Officer)</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">April 5, 2022</div>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">&#160;</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">&#160;</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">&#160;/s/ Amy Rabourn</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;"><br>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;"><br>
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            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Amy Rabourn</div>
                <div>&#160;</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Vice President of Finance</div>
                <div style="text-align: center; color: rgb(0, 0, 0);">(Principal Financial and Accounting Officer)</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">April 5, 2022</div>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;"><br>
              </td>
              <td style="width: 2%; vertical-align: top;"><br>
              </td>
              <td style="width: 39%; vertical-align: top;"><br>
              </td>
              <td style="width: 2%; vertical-align: top;"><br>
              </td>
              <td style="width: 18.44%; vertical-align: top;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">/s/ Sean Ainsworth</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);"><br>
                </div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);"><br>
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              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Sean Ainsworth</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top; text-align: center;">Director</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">April 5, 2022</div>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">&#160;</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">&#160;</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">/s/ James S. Manuso</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;"><br>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">James S. Manuso</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">April 5, 2022</div>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">&#160;</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">&#160;</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Cam Gallagher</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">
                <div>&#160;</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">
                <div>&#160;</div>
              </td>
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            <tr>
              <td style="width: 39.37%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Cam Gallagher</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">April 5, 2022</div>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">&#160;</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">&#160;</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Jay Pepose</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;"><br>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;"><br>
              </td>
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            <tr>
              <td style="width: 39.37%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Jay Pepose</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">April 5, 2022</div>
              </td>
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        </table>
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        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 39.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Richard J. Rodgers</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">
                <div>&#160;</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);"><br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Richard J. Rodgers</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top; text-align: center;">April 5, 2022</td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">&#160;</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">&#160;</td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Susan K. Benton</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;"><br>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 18.44%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);"><br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 39.37%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Susan K. Benton</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
              <td style="width: 39%; vertical-align: top;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
              </td>
              <td style="width: 2%; vertical-align: top;">&#160;</td>
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                <div style="text-align: center; color: rgb(0, 0, 0);">April 5, 2022</div>
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[{"type": "S-8", "sequence": "1", "filename": "brhc10035805_s8.htm", "description": "S-8", "secsgml_size_bytes": 51216}]
{"company-data": {"conformed-name": "Ocuphire Pharma, Inc.", "cik": "0001228627", "assigned-sic": "2834", "irs-number": "113516358", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-264139", "film-number": "22807048"}, "business-address": {"street1": "37000 GRAND RIVER AVE.", "street2": "SUITE 120", "city": "FARMINGTON HILLS", "state": "MI", "zip": "48335", "phone": "248-681-9815"}, "mail-address": {"street1": "37000 GRAND RIVER AVE.", "street2": "SUITE 120", "city": "FARMINGTON HILLS", "state": "MI", "zip": "48335"}, "former-company": [{"former-conformed-name": "REXAHN PHARMACEUTICALS, INC.", "date-changed": "20050516"}, {"former-conformed-name": "CORPORATE ROAD SHOW DOT COM INC", "date-changed": "20030423"}]}
As filed with the Securities and Exchange Commission on April 5, 2022
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Ocuphire Pharma, Inc.
(Exact name of registrant as specified in its charter)
Delaware
11-3516358
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer Identification No.)
37000 Grand River
Avenue, Suite 120
Farmington Hills, MI
48335
(Address of principal executive offices)
(Zip code)
Ocuphire Pharma, Inc. 2020 Equity Incentive Plan
(Full title of the plan)
Mina Sooch
President and Chief Executive Officer
Ocuphire Pharma, Inc.
37000 Grand River Avenue, Suite 120
Farmington Hills, MI 48335
(248) 681-9815
(Name, address, and telephone number, including area code, of agent for service)
Copy to:
Phillip D. Torrence, Esq.
Emily J. Johns, Esq.
Honigman LLP
650 Trade Center Way, Suite 200
Kalamazoo, Michigan 49002-0402
(269) 337-7700
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large
      accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☐ Accelerated filer ☐
Non-accelerated filer ☒ Smaller reporting company ☒
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
      Section 7(a)(2)(B) of the Securities Act. ☒
EXPLANATORY NOTE
This Registration Statement on Form S-8 is being filed by Ocuphire Pharma, Inc. (the "
Company
" or "Registrant" for the purpose of
      registering an additional 942,291 shares of Common Stock issuable pursuant to the Ocuphire Pharma, Inc. 2020 Equity Incentive Plan (the "
Equity Incentive Plan
").
Pursuant to General Instruction E to Form S-8, this Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a
      Registration Statement of the Company on Form S-8 relating to the Equity Incentive Plan is effective, and the Company's Registration Statements on Form S-8 previously filed with the Securities and Exchange Commission (the "
Commission
") on November 9, 2020 (File No. 333-249978) and March 31, 2021 (File No. 333-254923) registering shares of Common Stock issuable under the Equity Incentive Plan are incorporated by reference in this
      Registration Statement.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents By Reference.
The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:
(a)
the Registrant's Annual Report on Form 10-K filed on
March 24, 2022
;
(b)
the Registrant's Current Reports on Form 8-K filed on
January 31, 2022
and
March 29, 2022
; and
(c)
the description of the Company's Common Stock contained in the Company's Form 8-A (File No. 001-34079), as filed with
                the Commission pursuant to Sections 12(b) and 12(g) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), on
May 23, 2008
.
In addition, all documents the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the filing of this Registration Statement and prior to the filing
      of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities covered hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part
      hereof from the date of filing of such documents. Notwithstanding anything herein, the Registrant is not incorporating by reference any information furnished under Item 2.02 or Item 7.01 of any Current Report on Form 8-K, unless, and to the extent,
      specified in any such Current Report on Form 8-K.
Any statement herein or contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement
      to the extent that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated by reference herein, modifies or supersedes such prior statement. Any such statement so modified or superseded shall
      not be deemed, except as so modified or superseded, to constitute part of this Registration Statement.
Item 8.
Exhibits.
INDEX TO EXHIBITS
Exhibit
Number
Description
4.1
Amended and Restated Certificate of Incorporation (incorporated by reference to Appendix G to the Company's Definitive Proxy Statement on Schedule
                14A filed on April 29, 2005)
4.2
Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current
                Report on Form 8-K, filed on May 5, 2017)
4.3
Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current
                Report on Form 8-K, filed on August 30, 2018)
4.4
Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current
                Report on Form 8-K, filed on April 12, 2019).
4.5
Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current
                Report on Form 8-K, filed on November 6, 2020)
4.6
Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.2 to the Company's Current
                Report on Form 8-K, filed on November 6, 2020)
4.7
Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Company's Current Report on Form 8-K, filed
                on November 6, 2020)
4.8
Ocuphire Pharma, Inc. 2020 Equity Incentive Plan (incorporated by reference to Annex D to the Company's Registration Statement on Form S-4, filed
                on September 30, 2020)
5.1
Opinion of Honigman LLP
23.1
Consent of Ernst & Young LLP
23.2
Consent of Honigman LLP (included in Exhibit 5.1)
24.1
Power of Attorney (included after the signature of the Registrant contained on Signature Page of this Registration Statement)
107
Filing Fee Table
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
      duly caused this Registration Statement to be signed on its behalf by the undersigned, hereunto duly authorized, in City of Farmington Hills, State of Michigan, on April 5, 2022.
OCUPHIRE PHARMA, INC.
By:
/s/ Mina Sooch
Name:
Mina Sooch
Title:
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Mina Sooch, Bernhard Hoffmann and Amy Rabourn as his or her true and lawful
          attorneys-in-fact and agents with full power of substitution, severally, for him in any and all capacities, to sign the Registration Statement on Form S-8 of Ocuphire Pharma, Inc., and any or all amendments (including post-effective amendments
          thereto), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each
          and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or
          their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.
SIGNATURE
TITLE
DATE
/s/ Mina Sooch
Mina Sooch
President, Chief Executive Officer & Director
(Principal Executive Officer)
April 5, 2022
/s/ Amy Rabourn
Amy Rabourn
Vice President of Finance
(Principal Financial and Accounting Officer)
April 5, 2022
/s/ Sean Ainsworth
Sean Ainsworth
Director
April 5, 2022
/s/ James S. Manuso
James S. Manuso
Director
April 5, 2022
/s/ Cam Gallagher
Cam Gallagher
Director
April 5, 2022
/s/ Jay Pepose
Jay Pepose
Director
April 5, 2022
/s/ Richard J. Rodgers
Richard J. Rodgers
Director
April 5, 2022
/s/ Susan K. Benton
Susan K. Benton
Director
April 5, 2022