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  <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on May 17, 2022</div>
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    <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
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  <div style="text-align: center; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
  <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
  <div style="text-align: center; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
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  <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-8</div>
  <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
  <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
  <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
  <div style="text-align: center; font-style: italic; font-weight: bold;"> <br>
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  <div style="text-align: center; font-weight: bold;"> <br>
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  <div style="text-align: center; font-weight: bold; font-size: 24pt;">Immunocore Holdings plc</div>
  <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)<br>
    <br>
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          <div style="text-align: center; font-weight: bold;">England and Wales</div>
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        <td style="width: 1.68%; vertical-align: bottom;">&#160;</td>
        <td style="width: 49.16%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">Not applicable</div>
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        <td style="width: 49.17%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">(State or other jurisdiction of Incorporation or organization)</div>
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        <td style="width: 1.68%; vertical-align: bottom;">&#160;</td>
        <td style="width: 49.16%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">(I.R.S. Employer Identification No.)</div>
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  <div>&#160;</div>
  <div style="text-align: center; font-weight: bold;">92 Park Drive</div>
  <div style="text-align: center; font-weight: bold;">Milton Park</div>
  <div style="text-align: center; font-weight: bold;">Abingdon, Oxfordshire OX14 4RY</div>
  <div style="text-align: center; font-weight: bold;">United Kingdom</div>
  <div style="text-align: center; font-weight: bold;">(Address of principal executive offices) (Zip code)</div>
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  <div style="text-align: center; font-weight: bold;">Immunocore Holdings plc 2021 Equity Incentive Plan, with Non-Employee Sub-Plan</div>
  <div style="text-align: center; font-weight: bold;">(Full title of the plan)</div>
  <div style="text-align: center; font-weight: bold;"> <br>
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  <div style="text-align: center; font-size: 24pt; font-weight: bold;">Immunocore, LLC</div>
  <div style="text-align: center;">Six Tower Bridge, Suite 200</div>
  <div style="text-align: center;">181 Washington Street</div>
  <div style="text-align: center;">Conshohocken, Pennsylvania 19428</div>
  <div style="text-align: center;">United States</div>
  <div style="text-align: center;">Tel: +1 484 534 5261</div>
  <div style="text-align: center; font-weight: bold;">(Name and address of agent for service) (Telephone number, including area code, of agent for service)</div>
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  <div style="text-align: center; font-style: italic; font-weight: bold;"> <br>
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  <div style="text-align: center; font-style: italic; font-weight: bold;">Copies to:</div>
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          <div style="text-align: center; font-weight: bold;">Divakar Gupta</div>
          <div style="text-align: center; font-weight: bold;">Courtney T. Thorne</div>
          <div style="text-align: center; font-weight: bold;">Eric W. Blanchard</div>
          <div style="text-align: center; font-weight: bold;">Cooley LLP</div>
          <div style="text-align: center; font-weight: bold;">55 Hudson Yards</div>
          <div style="text-align: center; font-weight: bold;">New York, New York 10001</div>
          <div style="text-align: center; font-weight: bold;">+1 212 479 6000</div>
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        <td style="width: 34%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">Lily Hepworth</div>
          <div style="text-align: center; font-weight: bold;">General Counsel</div>
          <div style="text-align: center; font-weight: bold;">Immunocore Holdings plc</div>
          <div style="text-align: center; font-weight: bold;">92 Park Drive</div>
          <div style="text-align: center; font-weight: bold;">Milton Park</div>
          <div style="text-align: center; font-weight: bold;">Abingdon, Oxfordshire OX14 4RY</div>
          <div style="text-align: center; font-weight: bold;">United Kingdom</div>
          <div style="text-align: center; font-weight: bold;">Tel: +44 12 3543 8600</div>
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        <td style="width: 33%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">Claire Keast-Butler</div>
          <div style="text-align: center; font-weight: bold;">Cooley (UK) LLP</div>
          <div style="text-align: center; font-weight: bold;">22 Bishopsgate</div>
          <div style="text-align: center; font-weight: bold;">London EC2N 4BQ</div>
          <div style="text-align: center; font-weight: bold;">United Kingdom</div>
          <div style="text-align: center; font-weight: bold;">+44 20 7583 4055</div>
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  <div>&#160;</div>
  <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
    filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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          <div>Large accelerated filer</div>
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        <td style="width: 1.75%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45.01%; vertical-align: bottom;">
          <div>&#9744;</div>
        </td>
        <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
        <td style="width: 26.28%; vertical-align: bottom;">
          <div>Accelerated filer</div>
        </td>
        <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
        <td style="width: 3.04%; vertical-align: bottom;">
          <div>&#9744;</div>
        </td>
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        <td style="width: 20.38%; vertical-align: bottom;">
          <div>Non-accelerated filer</div>
        </td>
        <td style="width: 1.75%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45.01%; vertical-align: bottom;">
          <div>&#9746;</div>
        </td>
        <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
        <td style="width: 26.28%; vertical-align: bottom;">
          <div>Smaller reporting company</div>
        </td>
        <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
        <td style="width: 3.04%; vertical-align: bottom;">
          <div>&#9744;</div>
        </td>
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        <td style="width: 20.38%; vertical-align: top;">&#160;</td>
        <td style="width: 1.75%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45.01%; vertical-align: bottom;">&#160;</td>
        <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
        <td style="width: 26.28%; vertical-align: top;">
          <div>Emerging growth company</div>
        </td>
        <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
        <td style="width: 3.04%; vertical-align: top;">
          <div>&#9746;</div>
        </td>
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  <div>&#160;</div>
  <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
    Securities Act. &#9746;</div>
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  <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;"><font style="color: #000000;">The Registrant is filing this Registration Statement on Form S-8</font> for the purpose of registering an additional 2,193,143 ordinary shares, nominal value &#163;0.002 per
    share (&#8220;Ordinary Shares&#8221;) issuable under the Registrant's 2021 Equity Incentive Plan (the &#8220;2021 Plan&#8221;), resulting from an automatic annual increase as of January 1, 2022 pursuant to the &#8220;evergreen&#8221; provision of the 2021 Plan. This Registration
    Statement<font style="color: #000000;"> is being filed for the purpose of registering additional securities of the same class as other securities for which a Registration Statement on Form S-8 has previously been filed and is effective. Accordingly,
      this Registration Statement incorporates by reference the contents of the Registration Statement on Form S-8, File No. 333-255182, filed with the Securities and Exchange Commission on April 12, 2021, by the Registrant relating to the </font>2021
    Plan<font style="color: #000000;">, except for Item 8, Exhibits, with respect to which the Exhibit Index below is incorporated herein by reference.</font></div>
  <div>&#160;</div>
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            <div style="text-align: justify;"><font style="font-weight: bold;">Item 8.</font></div>
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          <td style="align: left; vertical-align: top; width: auto;">
            <div style="text-align: justify;"><font style="font-weight: bold;">Exhibits.</font></div>
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    <div> <br>
    </div>
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          <td style="width: 7.75%; vertical-align: bottom;">&#160;</td>
          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 41%; vertical-align: bottom; text-indent: -9pt; margin-left: 9pt;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="7">
            <div>
              <div style="text-align: center; font-weight: bold;">Incorporated by Reference</div>
            </div>
          </td>
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          <td style="width: 7.75%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div>
              <div style="text-align: center; font-weight: bold;">Number</div>
            </div>
          </td>
          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 41%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div>
              <div style="font-weight: bold; text-indent: -9pt; margin-left: 9pt;">Description</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Schedule</div>
            <div>
              <div style="text-align: center; font-weight: bold;">Form</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; border-bottom: 2px solid #000000;">
            <div>
              <div style="text-align: center; font-weight: bold;">File Number</div>
            </div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; border-bottom: 2px solid #000000;">
            <div>
              <div style="text-align: center; font-weight: bold;">Exhibit</div>
            </div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 15.06%; vertical-align: bottom; border-bottom: 2px solid #000000;">
            <div>
              <div style="text-align: center; font-weight: bold;">Filing Date</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 7.75%; vertical-align: top; background-color: #CCEEFF;">
            <div>4.1</div>
          </td>
          <td style="width: 2.56%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 41%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 238); text-indent: -9pt; margin-left: 9pt;"><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex1-1.htm">Articles of Association of Immunocore Holdings plc.</a></div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">20-F</div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: center;">001-39992</div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: center;">1.1</div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15.06%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: center;">3/25/21</div>
          </td>
        </tr>
        <tr>
          <td style="width: 7.75%; vertical-align: top;">
            <div>4.2</div>
          </td>
          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 41%; vertical-align: top;">
            <div style="color: rgb(0, 0, 238); text-indent: -9pt; margin-left: 9pt;"><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex2-2.htm">Deposit Agreement.</a></div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">
            <div style="text-align: center;">20-F</div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom;">
            <div style="text-align: center;">001-39992</div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom;">
            <div style="text-align: center;">2.2</div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 15.06%; vertical-align: bottom;">
            <div style="text-align: center;">3/25/21</div>
          </td>
        </tr>
        <tr>
          <td style="width: 7.75%; vertical-align: top; background-color: #CCEEFF;">
            <div>4.3</div>
          </td>
          <td style="width: 2.56%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 41%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 238); text-indent: -9pt; margin-left: 9pt;"><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex2-2.htm">Form of American Depositary Receipt (included in Exhibit 4.2).</a></div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">20-F</div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: center;">001-39992</div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: center;">2.3</div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15.06%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: center;">3/25/21</div>
          </td>
        </tr>
        <tr>
          <td style="width: 7.75%; vertical-align: top;">
            <div style="color: rgb(0, 0, 238);"><a href="brhc10037368_ex5-1.htm">5.1*</a></div>
          </td>
          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 41%; vertical-align: top;">
            <div style="text-indent: -9pt; margin-left: 9pt;">Opinion of Cooley (UK) LLP.</div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 15.06%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7.75%; vertical-align: top; background-color: #CCEEFF;">
            <div><a href="brhc10037368_ex23-1.htm">23.1*</a></div>
          </td>
          <td style="width: 2.56%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 41%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt;">Consent of KPMG LLP, the Registrant&#8217;s independent registered public accounting firm</div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15.06%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7.75%; vertical-align: top;">
            <div><a href="brhc10037368_ex5-1.htm">23.2*</a></div>
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          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 15.06%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 7.75%; vertical-align: top; background-color: #CCEEFF;">
            <div style="color: rgb(0, 0, 0);"><a href="#POWEROFATTORNEY">24.1*</a></div>
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          <td style="width: 2.56%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 41%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt;">Power of Attorney (included on the signature page of this Registration Statement)</div>
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          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15.06%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
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          <td style="width: 7.75%; vertical-align: top;">
            <div>99.1</div>
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          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 41%; vertical-align: top;">
            <div style="color: rgb(0, 0, 238); text-indent: -9pt; margin-left: 9pt;"><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex4-20.htm">Immunocore Holdings plc 2021 Equity Incentive Plan, including
                Non-Employee Sub-Plan to the Immunocore Holdings plc 2021 Equity Incentive Plan.</a></div>
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          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">
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            <div style="text-align: center;">001-39992</div>
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          <td style="width: 6.88%; vertical-align: bottom;">
            <div style="text-align: center;">4.20</div>
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          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
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            <div style="text-align: center;">3/25/21</div>
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        <tr>
          <td style="width: 7.75%; vertical-align: top; background-color: #CCEEFF;">
            <div><a href="brhc10037368_ex107.htm">107</a></div>
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          <td style="width: 2.56%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 41%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt;">Filing Fee Table</div>
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          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 15.06%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
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  <div>
    <div><br>
    </div>
    <div>
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        <td style="width: 18pt; vertical-align: top;">*</td>
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          <div>Filed herewith.</div>
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  <div>&#160;</div>
  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
    <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">1</font></div>
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  <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
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  <div>&#160;</div>
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          <div style="font-weight: bold;">IMMUNOCORE HOLDINGS PLC</div>
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      <tr>
        <td style="width: 49.9%; vertical-align: top;">&#160;</td>
        <td style="width: 3.19%; vertical-align: middle;">&#160;</td>
        <td style="width: 46.9%; vertical-align: middle;">&#160;</td>
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          <div>By:</div>
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          <div style="margin-left: 9pt;">/s/ Bahija Jallal, Ph.D.</div>
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      <tr>
        <td style="width: 49.9%; vertical-align: top;">&#160;</td>
        <td style="width: 3.19%; vertical-align: top;">&#160;</td>
        <td style="width: 46.9%; vertical-align: bottom;">
          <div style="margin-left: 9pt;">Bahija Jallal, Ph.D.</div>
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      <tr>
        <td style="width: 49.9%; vertical-align: top;">&#160;</td>
        <td style="width: 3.19%; vertical-align: top;">&#160;</td>
        <td style="width: 46.9%; vertical-align: bottom;">
          <div style="margin-left: 9pt;">Chief Executive Officer</div>
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      </tr>

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  <div>&#160;</div>
  <div style="text-align: center; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Bahija Jallal and Brian Di Donato, and each or any one of them, his or her true and lawful
    attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration
    Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and
    perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents,
    or any of them, or their or his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof.</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</div>
  <div>&#160;</div>
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        <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Title</div>
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        <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Date</div>
        </td>
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      <tr>
        <td style="width: 32.01%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top; padding-bottom: 2px;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top; padding-bottom: 2px;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top; padding-bottom: 2px;" rowspan="1">&#160;</td>
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        <td style="width: 32.01%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">/s/ Bahija Jallal, Ph.D.</div>
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        <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div>Chief Executive Officer and Director</div>
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        <td style="width: 2%; vertical-align: top;" rowspan="2">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div style="text-align: center;">May 17, 2022</div>
        </td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top;">
          <div style="text-align: center;">Bahija Jallal, Ph.D.</div>
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        <td style="width: 2%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
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      <tr>
        <td style="width: 32.01%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">/s/ Brian Di Donato</div>
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        <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div>Chief Financial Officer</div>
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        </td>
        <td style="width: 2%; vertical-align: top;" rowspan="2">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div style="text-align: center;">
            <div>May 17, 2022</div>
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      <tr>
        <td style="width: 32.01%; vertical-align: top;">
          <div style="text-align: center;">Brian Di Donato</div>
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        <td style="width: 2%; vertical-align: top;">&#160;</td>
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      <tr>
        <td style="width: 32.01%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
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        <td style="width: 32.01%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">/s/ Professor Sir John Bell</div>
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        <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div>Chairman of the Board of Directors</div>
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        <td style="width: 2%; vertical-align: top;" rowspan="2">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div style="text-align: center;">
            <div>May 17, 2022</div>
          </div>
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      <tr>
        <td style="width: 32.01%; vertical-align: top;">
          <div style="text-align: center;">Professor Sir John Bell</div>
        </td>
        <td style="width: 2%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">/s/ Travis Coy</div>
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        <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div>Director</div>
        </td>
        <td style="width: 2%; vertical-align: top;" rowspan="2">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div style="text-align: center;">
            <div>May 17, 2022</div>
          </div>
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      <tr>
        <td style="width: 32.01%; vertical-align: top;">
          <div style="text-align: center;">Travis Coy</div>
        </td>
        <td style="width: 2%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">/s/ Roy Herbst, M.D., Ph.D.</div>
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        <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div>Director</div>
        </td>
        <td style="width: 2%; vertical-align: top;" rowspan="2">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div style="text-align: center;">
            <div>May 17, 2022</div>
          </div>
        </td>
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      <tr>
        <td style="width: 32.01%; vertical-align: top;">
          <div style="text-align: center;">Roy Herbst, M.D., Ph.D.</div>
        </td>
        <td style="width: 2%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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        <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div>Director</div>
        </td>
        <td style="width: 2%; vertical-align: top;" rowspan="2">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div style="text-align: center;">
            <div>May 17, 2022</div>
          </div>
        </td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top;">
          <div style="text-align: center;">Robert Perez</div>
        </td>
        <td style="width: 2%; vertical-align: top;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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        <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div>Director</div>
        </td>
        <td style="width: 2%; vertical-align: top;" rowspan="2">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div style="text-align: center;">
            <div>May 17, 2022</div>
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      <tr>
        <td style="width: 32.01%; vertical-align: top;">
          <div style="text-align: center;">Kristine Peterson</div>
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        <td style="width: 2%; vertical-align: top;">&#160;</td>
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      <tr>
        <td style="width: 32.01%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.01%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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        <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div>Director</div>
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        <td style="width: 2%; vertical-align: top;" rowspan="2">&#160;</td>
        <td style="width: 32%; vertical-align: top;" rowspan="2">
          <div style="text-align: center;">
            <div>May 17, 2022</div>
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      <tr>
        <td style="width: 32.01%; vertical-align: top;">
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        <td style="width: 2%; vertical-align: top;">&#160;</td>
      </tr>

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  <div>&#160;</div>
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      <tr>
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          <div style="text-indent: -7.2pt; margin-left: 7.2pt; font-weight: bold;">Immunocore, LLC</div>
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        <td style="width: 47%; vertical-align: top;">&#160;</td>
        <td style="width: 14.93%; vertical-align: top;">
          <div style="text-indent: -7.2pt; margin-left: 7.2pt; text-align: center;">May 17, 2022</div>
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        <td style="vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
        <td style="width: 47%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 14.93%; vertical-align: top;" rowspan="1">&#160;</td>
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      <tr>
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          <div style="text-indent: -7.2pt; margin-left: 7.2pt;">By:</div>
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        <td style="width: 35%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="margin-left: 9pt">/s/ Bahija Jallal, Ph.D. </div>
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          <div style="margin-left: 9pt;">Authorized Representative in the United States</div>
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        <td style="vertical-align: top;" rowspan="1" colspan="2">
          <div style="text-indent: -7.2pt; margin-left: 16.2pt;">Name: Bahija Jallal, Ph.D.</div>
        </td>
        <td style="width: 14.93%; vertical-align: top;">&#160;</td>
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        <td style="vertical-align: top;" rowspan="1" colspan="2">
          <div style="text-indent: -7.2pt; margin-left: 16.2pt;">Title: Authorized Signatory</div>
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{"company-data": {"conformed-name": "Immunocore Holdings plc", "cik": "0001671927", "assigned-sic": "2836", "irs-number": "000000000", "state-of-incorporation": "X0", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-265000", "film-number": "22932212"}, "business-address": {"street1": "90 PARK DRIVE", "street2": "MILTON PARK, ABINGDON", "city": "OXFORDSHIRE", "state": "X0", "zip": "OX14 4RY", "phone": "01235 5430281"}, "mail-address": {"street1": "90 PARK DRIVE", "street2": "MILTON PARK, ABINGDON", "city": "OXFORDSHIRE", "state": "X0", "zip": "OX14 4RY"}, "former-company": {"former-conformed-name": "Immunocore Ltd", "date-changed": "20160412"}}
As filed with the Securities and Exchange Commission on May 17, 2022
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Immunocore Holdings plc
(Exact name of registrant as specified in its charter)
England and Wales
Not applicable
(State or other jurisdiction of Incorporation or organization)
(I.R.S. Employer Identification No.)
92 Park Drive
Milton Park
Abingdon, Oxfordshire OX14 4RY
United Kingdom
(Address of principal executive offices) (Zip code)
Immunocore Holdings plc 2021 Equity Incentive Plan, with Non-Employee Sub-Plan
(Full title of the plan)
Immunocore, LLC
Six Tower Bridge, Suite 200
181 Washington Street
Conshohocken, Pennsylvania 19428
United States
Tel: +1 484 534 5261
(Name and address of agent for service) (Telephone number, including area code, of agent for service)
Copies to:
Divakar Gupta
Courtney T. Thorne
Eric W. Blanchard
Cooley LLP
55 Hudson Yards
New York, New York 10001
+1 212 479 6000
Lily Hepworth
General Counsel
Immunocore Holdings plc
92 Park Drive
Milton Park
Abingdon, Oxfordshire OX14 4RY
United Kingdom
Tel: +44 12 3543 8600
Claire Keast-Butler
Cooley (UK) LLP
22 Bishopsgate
London EC2N 4BQ
United Kingdom
+44 20 7583 4055
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
    filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☐
Emerging growth company
☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
    Securities Act. ☒
EXPLANATORY NOTE
The Registrant is filing this Registration Statement on Form S-8
for the purpose of registering an additional 2,193,143 ordinary shares, nominal value £0.002 per
    share ("Ordinary Shares") issuable under the Registrant's 2021 Equity Incentive Plan (the "2021 Plan"), resulting from an automatic annual increase as of January 1, 2022 pursuant to the "evergreen" provision of the 2021 Plan. This Registration
    Statement
is being filed for the purpose of registering additional securities of the same class as other securities for which a Registration Statement on Form S-8 has previously been filed and is effective. Accordingly,
      this Registration Statement incorporates by reference the contents of the Registration Statement on Form S-8, File No. 333-255182, filed with the Securities and Exchange Commission on April 12, 2021, by the Registrant relating to the
2021
    Plan
, except for Item 8, Exhibits, with respect to which the Exhibit Index below is incorporated herein by reference.
Item 8.
Exhibits.
Incorporated by Reference
Exhibit
Number
Description
Schedule
Form
File Number
Exhibit
Filing Date
4.1
Articles of Association of Immunocore Holdings plc.
20-F
001-39992
1.1
3/25/21
4.2
Deposit Agreement.
20-F
001-39992
2.2
3/25/21
4.3
Form of American Depositary Receipt (included in Exhibit 4.2).
20-F
001-39992
2.3
3/25/21
5.1*
Opinion of Cooley (UK) LLP.
23.1*
Consent of KPMG LLP, the Registrant's independent registered public accounting firm
23.2*
Consent of Cooley (UK) LLP (included in Exhibit 5.1).
24.1*
Power of Attorney (included on the signature page of this Registration Statement)
99.1
Immunocore Holdings plc 2021 Equity Incentive Plan, including
                Non-Employee Sub-Plan to the Immunocore Holdings plc 2021 Equity Incentive Plan.
20-F
001-39992
4.20
3/25/21
107
Filing Fee Table
*
Filed herewith.
1
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
    and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Oxford, United Kingdom, on the 17th day of May, 2022.
IMMUNOCORE HOLDINGS PLC
By:
/s/ Bahija Jallal, Ph.D.
Bahija Jallal, Ph.D.
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Bahija Jallal and Brian Di Donato, and each or any one of them, his or her true and lawful
    attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration
    Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and
    perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents,
    or any of them, or their or his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Bahija Jallal, Ph.D.
Chief Executive Officer and Director
(
Principal Executive Officer
)
May 17, 2022
Bahija Jallal, Ph.D.
/s/ Brian Di Donato
Chief Financial Officer
(
Principal Financial Officer and Principal Accounting Officer)
May 17, 2022
Brian Di Donato
/s/ Professor Sir John Bell
Chairman of the Board of Directors
May 17, 2022
Professor Sir John Bell
/s/ Travis Coy
Director
May 17, 2022
Travis Coy
/s/ Roy Herbst, M.D., Ph.D.
Director
May 17, 2022
Roy Herbst, M.D., Ph.D.
/s/ Robert Perez
Director
May 17, 2022
Robert Perez
/s/ Kristine Peterson
Director
May 17, 2022
Kristine Peterson
/s/ Professor Sir Peter Ratcliffe
Director
May 17, 2022
Professor Sir Peter Ratcliffe
2
Immunocore, LLC
May 17, 2022
By:
/s/ Bahija Jallal, Ph.D.
Authorized Representative in the United States
Name: Bahija Jallal, Ph.D.
Title: Authorized Signatory
3