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      <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;" align="center">As filed with the Securities and Exchange Commission
      on August 13, 2020</div>
    <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 24pt; font-weight: bold;">Bionano Genomics, Inc.</div>
    <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z0b51cf0f2fe6490da4fb0f1f0529d403" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Delaware</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">26-1756290</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">(State or other jurisdiction of</div>
            <div style="text-align: center; font-weight: bold;">incorporation or organization)</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">(I.R.S. Employer</div>
            <div style="text-align: center; font-weight: bold;">Identification No.)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: middle;">&#160;</td>
          <td style="width: 50%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
            <div style="text-align: center; font-weight: bold;">San Diego, California</div>
          </td>
          <td style="width: 50%; vertical-align: bottom;">
            <div style="text-align: center; font-weight: bold;">92121</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">(Address of Principal Executive Offices)</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">(Zip Code)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Bionano Genomics, Inc. Amended and Restated 2018 Equity Incentive Plan</div>
    <div style="text-align: center; font-weight: bold;">(Full titles of the plans)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">R. Erik Holmlin, Ph.D.</div>
    <div style="text-align: center; font-weight: bold;">President and Chief Executive Officer</div>
    <div style="text-align: center; font-weight: bold;">Bionano Genomics, Inc.</div>
    <div style="text-align: center; font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
    <div style="text-align: center; font-weight: bold;">San Diego, California 92121</div>
    <div style="text-align: center; font-weight: bold;">(858) 888-7600</div>
    <div style="text-align: center; font-weight: bold;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">Copies to:</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z421f7f29458c48bb9322a0c5f72f3979" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Thomas A. Coll, Esq.</div>
            <div style="text-align: center; font-weight: bold;">James C. Pennington, Esq.</div>
            <div style="text-align: center; font-weight: bold;">Cooley LLP</div>
            <div style="text-align: center; font-weight: bold;">4401 Eastgate Mall</div>
            <div style="text-align: center; font-weight: bold;">San Diego, California 92121</div>
            <div style="text-align: center; font-weight: bold;">(858) 550-6000</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">R. Erik Holmlin, Ph.D.</div>
            <div style="text-align: center; font-weight: bold;">President and Chief Executive Officer</div>
            <div style="text-align: center; font-weight: bold;">Bionano Genomics, Inc.</div>
            <div style="text-align: center; font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
            <div style="text-align: center; font-weight: bold;">San Diego, California 92121</div>
            <div style="text-align: center; font-weight: bold;">(858) 888-7600</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221;&#160;&#8220;accelerated
      filer,&#8221;&#160;&#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z9faff5ecc02848b1b32b3a06e9766959" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td colspan="1" style="width: 5%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom;">
            <div>Large accelerated filer</div>
          </td>
          <td style="width: 30%; vertical-align: bottom;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
          </td>
          <td style="width: 20%; vertical-align: bottom;">
            <div>Accelerated filer</div>
          </td>
          <td style="width: 25%; vertical-align: bottom;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 5%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom;">&#160;</td>
          <td style="width: 30%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom;">&#160;</td>
          <td style="width: 25%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="width: 5%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom;">
            <div>Non-accelerated filer</div>
          </td>
          <td style="width: 30%; vertical-align: bottom;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</div>
          </td>
          <td style="width: 20%; vertical-align: bottom;">
            <div>Smaller reporting company</div>
          </td>
          <td style="width: 25%; vertical-align: bottom;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</div>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 5%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom;">&#160;</td>
          <td style="width: 30%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom;">&#160;</td>
          <td style="width: 25%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td colspan="1" style="width: 5%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom;">
            <div>Emerging growth company</div>
          </td>
          <td style="width: 30%; vertical-align: bottom;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</div>
          </td>
          <td style="width: 20%; vertical-align: bottom;">&#160;</td>
          <td style="width: 25%; vertical-align: bottom;">&#160;</td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div>If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. &#9744;</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zb72a33b14ba9484a8c1e691f0c2b5d05" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 44%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Title of Securities</div>
            <div style="text-align: center; font-weight: bold;">to be Registered</div>
          </td>
          <td style="width: 13.97%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Amount</div>
            <div style="text-align: center; font-weight: bold;">to be</div>
            <div style="text-align: center; font-weight: bold;">Registered<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
          <td style="width: 14%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Proposed</div>
            <div style="text-align: center; font-weight: bold;">Maximum</div>
            <div style="text-align: center; font-weight: bold;">Offering Price</div>
            <div style="text-align: center; font-weight: bold;">Per Share<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
          <td style="width: 14%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Proposed</div>
            <div style="text-align: center; font-weight: bold;">Maximum</div>
            <div style="text-align: center; font-weight: bold;">Aggregate</div>
            <div>&#160;</div>
            <div style="text-align: center; font-weight: bold;">Offering Price<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
          <td style="width: 14%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Amount of</div>
            <div style="text-align: center; font-weight: bold;">Registration Fee</div>
          </td>
        </tr>

    </table>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-indent: -10pt; margin-left: 10pt; font-weight: bold;">2018 Equity Incentive Plan</div>
            <div>Common Stock, $0.0001 par value per share</div>
          </td>
          <td style="width: 14%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">4,658,803<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
          </td>
          <td style="width: 14%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"> $0.78 </div>
          </td>
          <td style="width: 14%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"> $3,633,867 </div>
          </td>
          <td style="width: 14%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;"> $472 </div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z7f3aea00ebfa40cf8300790514c90d74" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 3.48%; vertical-align: top;">
            <div>(1)</div>
          </td>
          <td colspan="3" style="width: 96.52%; vertical-align: top;">
            <div>Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Securities Act</font>&#8221;), this Registration Statement shall also cover any additional shares of Common Stock (&#8220;<font style="font-weight: bold; font-style: italic;">Common Stock</font>&#8221;) of Bionano Genomics, Inc. (the &#8220;<font style="font-weight: bold; font-style: italic;">Registrant</font>&#8221;) that become issuable under the Registrant&#8217;s 2018 Equity Incentive
              Plan (the &#8220;<font style="font-weight: bold; font-style: italic;">2018 Plan</font>&#8221;) by reason of any stock dividend, stock split, recapitalization or other similar transaction.</div>
          </td>
        </tr>
        <tr>
          <td colspan="3" style="width: 3.61%; vertical-align: top;">
            <div>(2)</div>
          </td>
          <td style="width: 96.39%; vertical-align: top;">
            <div>This estimate is made pursuant to Rule 457(h)(1) and Rule 457(c) of the Securities Act solely for purposes of calculating the registration fee. The price per share and aggregate offering price are based upon the average of the high and low
              prices of the Common Stock on August 12, 2020, as reported on the Nasdaq Capital Market.</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="width: 3.54%; vertical-align: top;">
            <div>(3)</div>
          </td>
          <td colspan="2" style="width: 96.46%; vertical-align: top;">
            <div>Represents an increase in the number of shares of Common Stock reserved for issuance under the 2018 Plan pursuant to an amendment to the 2018 Plan approved by the Registrant&#8217;s stockholders at the Registrant&#8217;s Annual Meeting of Stockholders
              held on June 30, 2020.</div>
          </td>
        </tr>

    </table>
    <div>
      <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
    </div>
    <div style="text-align: center; font-weight: bold;">INCORPORATION OF DOCUMENTS BY REFERENCE</div>
    <div><br>
    </div>
    <div>This Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which Registration Statements of the Registrant on Form S-8 relating to the 2018 Plan are effective.</div>
    <div><br>
    </div>
    <div>The Registrant previously registered shares of its Common Stock for issuance under the 2018 Plan under Registration Statements on Form S-8 filed with the Securities and Exchange Commission on <a href="http://www.sec.gov/Archives/edgar/data/1411690/000119312518260602/d616702ds8.htm">August 28, 2018</a> (File No. 333-227073), <a href="http://www.sec.gov/Archives/edgar/data/1411690/000119312519091060/d626460ds8.htm">March 29, 2019</a> (File
      No. 333-230589) and <a href="http://www.sec.gov/Archives/edgar/data/1411690/000114036120005371/nt10009730x2_s8.htm">March 11, 2020</a> (File No. 333-237069). Pursuant to General Instruction E to Form S-8, this Registration Statement hereby
      incorporates by reference the contents of the Registration Statements referenced above.</div>
    <div><br>
    </div>
    <div style="font-weight: bold;">ITEM 8. EXHIBITS.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z61203f2e4a3343478663317c342faf9d" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 10.38%; vertical-align: bottom;">
            <div style="font-weight: bold;">Exhibit Number</div>
          </td>
          <td style="width: 89.56%; vertical-align: bottom;">
            <div style="text-align: center; font-weight: bold;">Description</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.38%; vertical-align: top;">
            <div><a href="http://www.sec.gov/Archives/edgar/data/1411690/000119312518257763/d607608dex31.htm">4.1</a><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
          <td style="width: 89.56%; vertical-align: top;">
            <div>Amended and Restated Certificate of Incorporation of the Registrant.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.38%; vertical-align: top;">
            <div><a href="http://www.sec.gov/Archives/edgar/data/1411690/000119312518257763/d607608dex32.htm">4.2</a><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
          <td style="width: 89.56%; vertical-align: top;">
            <div>Amended and Restated Bylaws of the Registrant.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.38%; vertical-align: top;">
            <div><a href="http://www.sec.gov/Archives/edgar/data/0001411690/000119312518219135/d782664dex41.htm">4.3</a><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
          <td style="width: 89.56%; vertical-align: top;">
            <div>Form of Common Stock Certificate of the Registrant.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.38%; vertical-align: top;">
            <div><a href="nt10014149x1_ex5-1.htm">5.1</a></div>
          </td>
          <td style="width: 89.56%; vertical-align: top;">
            <div>Opinion of Cooley LLP.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.38%; vertical-align: top;">
            <div><a href="nt10014149x1_ex23-1.htm">23.1</a></div>
          </td>
          <td style="width: 89.56%; vertical-align: top;">
            <div>Consent of Independent Registered Public Accounting Firm.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.38%; vertical-align: top;">
            <div><a href="nt10014149x1_ex5-1.htm">23.2</a></div>
          </td>
          <td style="width: 89.56%; vertical-align: top;">
            <div>Consent of Cooley LLP. Reference is made to Exhibit 5.1.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.38%; vertical-align: top;">
            <div><a href="#POWEROFATTORNEY">24.1</a></div>
          </td>
          <td style="width: 89.56%; vertical-align: top;">
            <div>Power of Attorney. Reference is made to the signature page hereto.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.38%; vertical-align: top;">
            <div><a href="nt10014149x1_ex99-1.htm">99.1</a><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">*</sup></div>
          </td>
          <td style="width: 89.56%; vertical-align: top;">Bionano Genomics, Inc. 2018 Equity Incentive Plan, as amended.</td>
        </tr>
        <tr>
          <td style="width: 10.38%; vertical-align: top;">
            <div><a href="http://www.sec.gov/Archives/edgar/data/1411690/000119312518219135/d782664dex105.htm">99.2</a><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
          <td style="width: 89.56%; vertical-align: top;">
            <div>Forms of Stock Option Grant Notice, Option Agreement and Notice of Exercise under the 2018 Plan.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 3.48%; vertical-align: top;">
            <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
          <td style="width: 94.96%; vertical-align: top;">
            <div>Incorporated by reference to the Registrant&#8217;s Current Report on Form 8-K, filed with the SEC on August 24, 2018.</div>
          </td>
          <td style="width: 1.56%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 3.48%; vertical-align: top;">
            <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
          <td style="width: 94.96%; vertical-align: top;">
            <div>Incorporated by reference to the Registrant&#8217;s Registration Statement on Form S-1 (File No. 333-225970), as amended.</div>
          </td>
          <td style="width: 1.56%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 3.48%; vertical-align: top;">
            <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">*</sup></div>
          </td>
          <td style="width: 94.96%; vertical-align: top;">
            <div>Filed herewith.</div>
          </td>
          <td style="width: 1.56%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div>
      <div><br>
      </div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
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    <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
    <div><br>
    </div>
    <div>Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement
      to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on August 13, 2020.</div>
    <div><br>
    </div>
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        <tr>
          <td colspan="2" style="vertical-align: top;">
            <div style="text-indent: -10pt; margin-left: 10pt; font-weight: bold;">BIONANO GENOMICS, INC.</div>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 5%; vertical-align: middle;">&#160;</td>
          <td style="width: 45%; vertical-align: middle;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
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        <tr>
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            <div style="text-indent: -10pt; margin-left: 10pt;">By:</div>
          </td>
          <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-indent: -10pt; margin-left: 10pt;">/s/ R. Erik Holmlin, Ph.D.</div>
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          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 45%; vertical-align: bottom;">
            <div style="text-indent: -10pt; margin-left: 10pt;">R. Erik Holmlin, Ph.D.</div>
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    <div><br>
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    <div style="text-align: center; font-weight: bold;">POWER OF ATTORNEY<a name="POWEROFATTORNEY"><!--Anchor--></a></div>
    <div><br>
    </div>
    <div>KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints R. Erik Holmlin, Ph.D. as his or her true and lawful attorney-in-fact and agent, with the full power of substitution, for him or her and in his or
      her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with exhibits thereto and other documents in connection therewith, with
      the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and
      purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</div>
    <div><br>
    </div>
    <div>Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</div>
    <div><br>
    </div>
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            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
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            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
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        <tr>
          <td style="width: 31.58%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: bottom;">&#160;</td>
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        <tr>
          <td style="width: 31.58%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">/s/ R. Erik Holmlin, Ph.D.</div>
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            <div style="text-align: center;">August 13, 2020</div>
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        <tr>
          <td style="width: 31.58%; vertical-align: top;">
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            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 31.58%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 31.58%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">/s/ Mark Adamchak</div>
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          <td rowspan="2" style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td rowspan="2" style="width: 42.11%; vertical-align: top;">
            <div style="text-align: center;">Controller</div>
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          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: top;">
            <div style="text-align: center;">August 13, 2020</div>
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        <tr>
          <td style="width: 31.58%; vertical-align: top;">
            <div style="text-align: center;">Mark Adamchak</div>
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            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
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          <td style="width: 31.58%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
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          <td style="width: 31.58%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">/s/ David L. Barker, Ph.D.</div>
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            <div>&#8203;</div>
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          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">
            <div style="text-align: center;">August 13, 2020</div>
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          <td style="width: 31.58%; vertical-align: top;">
            <div style="text-align: center;">David L. Barker, Ph.D.</div>
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            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 31.58%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
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          <td style="width: 31.58%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">/s/ Yvonne Linney, Ph.D.</div>
          </td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: top;">
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          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">
            <div style="text-align: center;">August 13, 2020</div>
          </td>
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        <tr>
          <td style="width: 31.58%; vertical-align: top;">
            <div style="text-align: center;">Yvonne Linney, Ph.D.</div>
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          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 31.58%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 31.58%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">/s/ Albert A. Luderer, Ph.D.</div>
          </td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 42.11%; vertical-align: top;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">
            <div style="text-align: center;">August 13, 2020</div>
          </td>
        </tr>
        <tr>
          <td style="width: 31.58%; vertical-align: top;">
            <div style="text-align: center;">Albert A. Luderer, Ph.D.</div>
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          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 31.58%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 31.58%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">/s/ Hannah Mamuszka</div>
          </td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 42.11%; vertical-align: top;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">
            <div style="text-align: center;">August 13, 2020</div>
          </td>
        </tr>
        <tr>
          <td style="width: 31.58%; vertical-align: top;">
            <div style="text-align: center;">Hannah Mamuszka</div>
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          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
          </td>
          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 31.58%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
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          <td style="width: 31.58%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">/s/ Christopher Twomey</div>
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          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: top;">
            <div style="text-align: center;">Director</div>
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          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: top;">
            <div style="text-align: center;">August 13, 2020</div>
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        </tr>
        <tr>
          <td style="width: 31.58%; vertical-align: top;">
            <div style="text-align: center;">Christopher Twomey</div>
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            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
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          <td style="width: 31.58%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: top;">&#160;</td>
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          <td style="width: 31.58%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">/s/ Kristiina Vuori, M.D., Ph.D.</div>
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            <div>&#8203;</div>
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          <td style="width: 1.32%; vertical-align: middle;">
            <div>&#8203;</div>
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          <td style="width: 23.68%; vertical-align: top;">
            <div style="text-align: center;">August 13, 2020</div>
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            <div style="text-align: center;">Kristiina Vuori, M.D., Ph.D.</div>
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            <div>&#8203;</div>
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          <td style="width: 42.11%; vertical-align: top;">&#160;</td>
          <td style="width: 1.32%; vertical-align: middle;">
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{"company-data": {"conformed-name": "Bionano Genomics, Inc", "cik": "0001411690", "assigned-sic": "3826", "irs-number": "261756290", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-245764", "film-number": "201100824"}, "business-address": {"street1": "9540 TOWNE CENTRE DRIVE", "street2": "SUITE 100", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "(858) 888-7600"}, "mail-address": {"street1": "9540 TOWNE CENTRE DRIVE", "street2": "SUITE 100", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}, "former-company": [{"former-conformed-name": "BioNano Genomics, Inc", "date-changed": "20120703"}, {"former-conformed-name": "BioNanomatrix Inc", "date-changed": "20070906"}]}
As filed with the Securities and Exchange Commission
      on August 13, 2020
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Bionano Genomics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
26-1756290
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
9540 Towne Centre Drive, Suite 100
San Diego, California
92121
(Address of Principal Executive Offices)
(Zip Code)
Bionano Genomics, Inc. Amended and Restated 2018 Equity Incentive Plan
(Full titles of the plans)
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
Bionano Genomics, Inc.
9540 Towne Centre Drive, Suite 100
San Diego, California 92121
(858) 888-7600
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
Thomas A. Coll, Esq.
James C. Pennington, Esq.
Cooley LLP
4401 Eastgate Mall
San Diego, California 92121
(858) 550-6000
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
Bionano Genomics, Inc.
9540 Towne Centre Drive, Suite 100
San Diego, California 92121
(858) 888-7600
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
      filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☒
If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. ☐
CALCULATION OF REGISTRATION FEE
Title of Securities
to be Registered
Amount
to be
Registered
(1)
Proposed
Maximum
Offering Price
Per Share
(2)
Proposed
Maximum
Aggregate
Offering Price
(2)
Amount of
Registration Fee
2018 Equity Incentive Plan
Common Stock, $0.0001 par value per share
4,658,803
(3)
$0.78
$3,633,867
$472
(1)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "
Securities Act
"), this Registration Statement shall also cover any additional shares of Common Stock ("
Common Stock
") of Bionano Genomics, Inc. (the "
Registrant
") that become issuable under the Registrant's 2018 Equity Incentive
              Plan (the "
2018 Plan
") by reason of any stock dividend, stock split, recapitalization or other similar transaction.
(2)
This estimate is made pursuant to Rule 457(h)(1) and Rule 457(c) of the Securities Act solely for purposes of calculating the registration fee. The price per share and aggregate offering price are based upon the average of the high and low
              prices of the Common Stock on August 12, 2020, as reported on the Nasdaq Capital Market.
(3)
Represents an increase in the number of shares of Common Stock reserved for issuance under the 2018 Plan pursuant to an amendment to the 2018 Plan approved by the Registrant's stockholders at the Registrant's Annual Meeting of Stockholders
              held on June 30, 2020.
INCORPORATION OF DOCUMENTS BY REFERENCE
This Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which Registration Statements of the Registrant on Form S-8 relating to the 2018 Plan are effective.
The Registrant previously registered shares of its Common Stock for issuance under the 2018 Plan under Registration Statements on Form S-8 filed with the Securities and Exchange Commission on
August 28, 2018
(File No. 333-227073),
March 29, 2019
(File
      No. 333-230589) and
March 11, 2020
(File No. 333-237069). Pursuant to General Instruction E to Form S-8, this Registration Statement hereby
      incorporates by reference the contents of the Registration Statements referenced above.
ITEM 8. EXHIBITS.
Exhibit Number
Description
4.1
(1)
Amended and Restated Certificate of Incorporation of the Registrant.
4.2
(1)
Amended and Restated Bylaws of the Registrant.
4.3
(2)
Form of Common Stock Certificate of the Registrant.
5.1
Opinion of Cooley LLP.
23.1
Consent of Independent Registered Public Accounting Firm.
23.2
Consent of Cooley LLP. Reference is made to Exhibit 5.1.
24.1
Power of Attorney. Reference is made to the signature page hereto.
99.1
*
Bionano Genomics, Inc. 2018 Equity Incentive Plan, as amended.
99.2
(2)
Forms of Stock Option Grant Notice, Option Agreement and Notice of Exercise under the 2018 Plan.
(1)
Incorporated by reference to the Registrant's Current Report on Form 8-K, filed with the SEC on August 24, 2018.
(2)
Incorporated by reference to the Registrant's Registration Statement on Form S-1 (File No. 333-225970), as amended.
*
Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement
      to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on August 13, 2020.
BIONANO GENOMICS, INC.
By:
/s/ R. Erik Holmlin, Ph.D.
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints R. Erik Holmlin, Ph.D. as his or her true and lawful attorney-in-fact and agent, with the full power of substitution, for him or her and in his or
      her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with exhibits thereto and other documents in connection therewith, with
      the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and
      purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
​
Title
​
Date
​
​
/s/ R. Erik Holmlin, Ph.D.
​
Chief Executive Officer and Director
(Principal Executive and Financial Officer)
​
August 13, 2020
R. Erik Holmlin, Ph.D.
​
​
​
/s/ Mark Adamchak
​
Controller
(Principal Accounting Officer)
​
August 13, 2020
Mark Adamchak
​
​
​
/s/ David L. Barker, Ph.D.
​
Director
​
August 13, 2020
David L. Barker, Ph.D.
​
​
​
​
/s/ Yvonne Linney, Ph.D.
​
Director
​
August 13, 2020
Yvonne Linney, Ph.D.
​
​
​
​
/s/ Albert A. Luderer, Ph.D.
​
Director
​
August 13, 2020
Albert A. Luderer, Ph.D.
​
​
​
​
/s/ Hannah Mamuszka
​
Director
​
August 13, 2020
Hannah Mamuszka
​
​
​
​
/s/ Christopher Twomey
​
Director
​
August 13, 2020
Christopher Twomey
​
​
​
​
/s/ Kristiina Vuori, M.D., Ph.D.
​
Director
​
August 13, 2020
Kristiina Vuori, M.D., Ph.D.
​
​