<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Financial Solutions, Inc.
         Document created using Broadridge PROfile 23.2.1.5134
         Copyright 1995 - 2023 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">As filed with the Securities and Exchange Commission on March 9, 2023</div>
    <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">Registration No. 333-</div>
    <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;">
    <div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">UNDER</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;">Bionano Genomics, Inc.</div>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z734b07d6f6e74f82aa820d7c27bf01b7">

        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">26-1756290</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or other jurisdiction of incorporation or organization)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer Identification No.)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z37a42709f44b442e9ae0f9c80c8f04d1">

        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">92121</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Address of Principal Executive Offices)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Zip Code)</div>
          </td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc. Amended and Restated 2018 Equity Incentive Plan, as amended</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc. 2018 Employee Stock Purchase Plan</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc. 2020 Inducement Plan, as amended</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Full titles of the plans)</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">R. Erik Holmlin, Ph.D.</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">President and Chief Executive Officer</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc.</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California 92121</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(858) 888-7600</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">Copies to:</div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z261cfb3207f144e8987cf71dfb0b0a10">

        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Thomas A. Coll, Esq.</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Phillip S. McGill, Esq.</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Cooley LLP</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">10265 Science Center Drive</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California 92121</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(858) 550-6000</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">R. Erik Holmlin, Ph.D.</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">President and Chief Executive Officer</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc.</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California 92121</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(858) 888-7600</div>
          </td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div style="text-align: justify; color: rgb(0, 0, 0);">Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the
      definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zef9dc1483f82497b8c4a769976fe2ab8">

        <tr>
          <td style="width: 43.04%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Large accelerated filer</div>
          </td>
          <td style="width: 6.95%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">&#9744;</div>
          </td>
          <td style="width: 43.04%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Accelerated filer</div>
          </td>
          <td style="width: 6.95%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.04%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
          </td>
          <td style="width: 6.95%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">&#9746;</div>
          </td>
          <td style="width: 43.04%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Smaller reporting company</div>
          </td>
          <td style="width: 6.95%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">&#9746;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 43.04%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Emerging growth company</div>
          </td>
          <td style="width: 6.95%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">&#9744;</div>
          </td>
          <td style="width: 43.04%; vertical-align: top;">&#160;</td>
          <td style="width: 6.95%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div style="text-align: justify; color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
      provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
    <div style="color: rgb(0, 0, 0);"> <br>
    </div>
    <div style="color: rgb(0, 0, 0);">
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">EXPLANATORY NOTE</div>
    <div><br>
    </div>
    <div style="text-align: justify;"><font style="color: rgb(0, 0, 0);">This Registration Statement on Form S-8 is being filed by Bionano Genomics, Inc. (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: rgb(0, 0, 0);">Registrant</font><font style="color: rgb(0, 0, 0);">&#8221;) for the purpose of registering (i) an additional </font>14,850,682 <font style="color: rgb(0, 0, 0);">shares of Registrant&#8217;s Common Stock, par value $0.0001 per share (&#8220;</font><font style="font-weight: bold; font-style: italic; color: rgb(0, 0, 0);">Common Stock</font><font style="color: rgb(0, 0, 0);">&#8221;), under the Registrant&#8217;s 2018 Equity Incentive Plan, as amended (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: rgb(0, 0, 0);">2018






        Plan</font><font style="color: rgb(0, 0, 0);">&#8221;), pursuant to the provisions of the 2018 Plan providing for an automatic increase in the number of shares of Common Stock reserved and available for issuance under the 2018 Plan, (ii) </font>220,000
      additional shares of Common Stock under the Registrant&#8217;s 2018 Employee Stock Purchase Plan (the &#8220;<font style="font-weight: bold; font-style: italic;">2018 ESPP</font>&#8221;) pursuant to the provisions of the 2018 ESPP providing for an automatic increase
      in the number of shares of Common Stock reserved and available for issuance under the 2018 ESPP, and (iii) 1,000,000 additional shares of Common Stock under the Registrant&#8217;s 2020 Inducement Plan, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Inducement Plan</font>&#8221;), for an aggregate of 4,100,000 shares of Common Stock issuable under the Inducement Plan, pursuant to an amendment to the Inducement Plan approved by the Board of Directors of the Registrant on November
      21, 2022.</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">PART II</div>
    <div><br>
    </div>
    <div style="text-align: center; margin-right: 6.7pt; margin-left: 4.8pt; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div>&#160;</div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="z206f4fc418da4d649cef786e18916f79" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="text-align: left; font-weight: bold;">Item 3.</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left; font-weight: bold;">Incorporation of Documents by Reference.</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify;">
      <div><font style="color: rgb(0, 0, 0);">These additional shares of Common Stock are securities of the same class as other securities for which a Registration Statement of the Registrant on Form S-8 relating to the 2018 Plan, the 2018 ESPP, and the
          Inducement Plan are effective. The Registrant previously registered shares of its Common Stock for issuance under the 2018 Plan and 2018 ESPP under Registration Statements on Form S-8 filed with the Securities and Exchange Commission on <a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518260602/d616702ds8.htm">August 28, 2018</a> (File No. 333-227073), <a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312519091060/d626460ds8.htm">March 29, 2019</a>
          (File No. 333-230589), <a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036120005371/nt10009730x2_s8.htm">March 11, 2020</a> (File No. 333-237069), <a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036120018366/nt10014149x1_s8.htm">August 14, 2020</a> (File No. 333-245764), <a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036121009780/nt10022040x2_s8.htm">March 24,
            2021</a> (File No. 333-254654), and <a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036122007373/brhc10034627_s8.htm">March 1, 2022</a> (File No. 333-263176). The Registrant previously registered shares of its Common Stock for
          issuance under the Inducement Plan under Registration Statements on Form S-8 filed with the Securities and Exchange Commission on <a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036120019327/nt10014149x5_s8.htm">August 28, 2020</a>
          (File No. 333-248468) and <a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036121036566/brhc10030312_s8.htm">November 4, 2021</a> (File No. 333-260762). Pursuant to General Instruction E to Form S-8, this Registration Statement
          hereby incorporates by reference the contents of the Registration Statements referenced above.</font></div>
    </div>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="z1c079da721d1441d8a06078033b06517" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="text-align: left; color: rgb(0, 0, 0); font-weight: bold;">Item 8.</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left; color: rgb(0, 0, 0); font-weight: bold;">Exhibits.</div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z6072ff139e1240bba676d14b13aa78b0">

          <tr>
            <td style="width: 8.31%; vertical-align: bottom; border-bottom: #000000 2px solid;">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibit</div>
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Number</div>
            </td>
            <td style="width: 1.92%; vertical-align: top;">&#160;</td>
            <td style="width: 89.76%; vertical-align: bottom; border-bottom: #000000 2px solid;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Description</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>4.1<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(1)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 89.76%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/0001411690/000141169021000004/ex31-arcertificateofincorp.htm">Amended and Restated Certificate of Incorporation of the Registrant, as amended</a><font style="color: rgb(0, 0, 0);">.</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top;">
              <div>4.2<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(2)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top;">&#160;</td>
            <td style="width: 89.76%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518257763/d607608dex32.htm">Amended and Restated Bylaws of the Registrant</a><font style="color: rgb(0, 0, 0);">.</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>4.3<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(3)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 89.76%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518219135/d782664dex41.htm">Form of Common Stock Certificate of the Registrant</a><font style="color: rgb(0, 0, 0);">.</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top;">
              <div>4.4<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(4)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top;">&#160;</td>
            <td style="width: 89.76%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 255); font-size: 12pt;"><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312519074842/d700738dex43.htm" style="font-size: 10pt;">Registration Rights Agreement, dated March 14, 2019, by and among the
                  Company and the Innovatus Investors.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>5.1</div>
            </td>
            <td style="width: 1.92%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 89.76%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);"><a href="brhc10049419_ex5-1.htm">Opinion of Cooley LLP.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top;">
              <div>23.1</div>
            </td>
            <td style="width: 1.92%; vertical-align: top;">&#160;</td>
            <td style="width: 89.76%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);"><a href="brhc10049419_ex23-1.htm">Consent of BDO USA LLP, Independent Registered Public Accounting Firm.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>23.2</div>
            </td>
            <td style="width: 1.92%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 89.76%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);"><a href="brhc10049419_ex5-1.htm">Consent of Cooley LLP. Reference is made to Exhibit 5.1.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top;">
              <div>24.1</div>
            </td>
            <td style="width: 1.92%; vertical-align: top;">&#160;</td>
            <td style="width: 89.76%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);"><a href="#POWEROFATTORNEY">Power of Attorney. Reference is made to the signature page hereto.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>99.1<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(5)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 89.76%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036120018366/nt10014149x1_ex99-1.htm">Bionano Genomics, Inc. 2018 Equity Incentive Plan, as amended (the &#8220;2018 Plan&#8221;)</a><font style="color: rgb(0, 0, 0);">.</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top;">
              <div>99.1A<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(6)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top;">&#160;</td>
            <td style="width: 89.76%; vertical-align: bottom;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000141169023000010/exh102a-bionanoxstandardfo.htm">Forms of grant notice, stock option agreement and notice of exercise under the 2018 Plan.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>99.1B<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(6)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 89.76%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000141169023000010/exh102b-bionanoxdirectorfo.htm">Forms of director grant notice, stock option agreement and notice of exercise under the 2018 Plan.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top;">
              <div>99.1C<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(6)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top;">&#160;</td>
            <td style="width: 89.76%; vertical-align: bottom;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000141169023000010/exh102c-bionanoxdoublextri.htm">Forms of double-trigger grant notice, stock option agreement and notice of exercise under the 2018 Plan.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>99.1D<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(3)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 89.76%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 255); font-size: 12pt;"><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518219135/d782664dex105.htm" style="font-size: 10pt;">Forms of international grant notice, stock option agreement and
                  notice of exercise under the 2018 Plan.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top;">
              <div>99.1E<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(7)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top;">&#160;</td>
            <td style="width: 89.76%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 255);"><a href="https://www.sec.gov/Archives/edgar/data/1411690/000141169021000024/bngo-20210630xexx101.htm">Forms of restricted stock unit grant notice and restricted stock unit award agreement under the 2018
                  Plan.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>99.2<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(8)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 89.76%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518260602/d616702dex995.htm">Bionano Genomics, Inc. 2018 Employee Stock Purchase Plan</a><font style="color: rgb(0, 0, 0);">.</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top;">
              <div>99.3<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(9)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top;">&#160;</td>
            <td style="width: 89.76%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036122043313/brhc10044740_ex10-1.htm">Bionano Genomics, Inc. 2020 Inducement Plan, as amended</a>.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>99.3A<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><font style="font-size: 8.5pt;">(10)</font></sup></div>
            </td>
            <td style="width: 1.92%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 89.76%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036120018910/brhc10014594_ex10-2.htm">Form of Stock Option Grant Notice and Stock Option Agreement under the Bionano Genomics, Inc. 2020 Inducement Plan, as amended</a>.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.31%; vertical-align: top;">
              <div>107</div>
            </td>
            <td style="width: 1.92%; vertical-align: top;">&#160;</td>
            <td style="width: 89.76%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);"><a href="brhc10049419_ex107-1.htm">Filing Fee Table.</a></div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z1e8fdd29301b4af587e1afb407ad4f03">

        <tr>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Annual Report on Form 10-K, filed with the SEC on March 23, 2021.</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z53da4fef9d7d417ab3499f018df9b573">

        <tr>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Current Report on Form 8-K, filed with the SEC on August 24, 2018.</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2bb41b3ee0b0479dbef1555b977d0d0f">

        <tr>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Registration Statement on Form S-1 (File No. 333-225970), as amended.</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6c653464a608496a8e7bf7bc8fc2ee41">

        <tr>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(4)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Current Report on Form 8-K, filed with the SEC on March 14, 2019.</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2d80a8554f5c4ac1ad1eef4651911a9e">

        <tr>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(5)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Registration Statement on Form S-8 (File No. 333-245764).</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z9e5fea0a81da4edabfcfeda1f2d3aede">

        <tr>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(6)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Annual Report on Form 10-K, filed with the SEC on March 9, 2023.</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="za87f8488e90a496aae6a6be65f4d3dbb">

        <tr>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(7)</td>
          <td style="width: auto; vertical-align: top;">
            <div><font style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Quarterly Report on Form 10-Q, filed with the SEC on </font>August 4, <font style="color: rgb(0, 0, 0);">2021.</font></div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z8a52ede8ee0a48cc9cc5f9b3f420983c">

        <tr>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(8)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Registration Statement on Form S-8 (File No. 333-227073).</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z3a2f0cf2191b45af95287b30740ddf8d">

        <tr>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(9)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Current Report on Form 8-K, filed with the SEC on November 28, 2022</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z924f6033bea045c285dd8cf94f2933f3">

        <tr>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(10)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Current Report on Form 8-K, filed with the SEC on August 24, 2020.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">SIGNATURES</div>
    <div><br>
    </div>
    <div style="text-align: justify; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
      S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on March 9, 2023.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z9350efea19cf421d96fb627c4d7f0125">

        <tr>
          <td colspan="2" style="width: 50%; vertical-align: top;">
            <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0); font-weight: bold;">BIONANO GENOMICS, INC.</div>
          </td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4%; vertical-align: middle;">&#160;</td>
          <td style="width: 46%; vertical-align: middle;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4%; vertical-align: top;">
            <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0);">By:</div>
          </td>
          <td style="width: 46%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0);">/s/ R. Erik Holmlin, Ph.D.</div>
          </td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4%; vertical-align: top;">&#160;</td>
          <td style="width: 46%; vertical-align: bottom;">
            <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0);">R. Erik Holmlin, Ph.D.</div>
          </td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 4%; vertical-align: top;">&#160;</td>
          <td style="width: 46%; vertical-align: bottom;">
            <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0); font-style: italic;">President and Chief Executive Officer</div>
          </td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">POWER OF ATTORNEY<a name="POWEROFATTORNEY"><!--Anchor--></a></div>
    <div><br>
    </div>
    <div style="text-align: justify; color: rgb(0, 0, 0);">KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints each of R. Erik Holmlin, Ph.D. and Christopher Stewart as his or her true and lawful
      attorney-in-fact and agent, with the full power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments),
      and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and
      thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or
      substitutes, may lawfully do or cause to be done by virtue hereof.</div>
    <div><br>
    </div>
    <div style="text-align: justify; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z5b63ed519a2140d8b14bcd52d49183e1">

        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Signature</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Title</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Date</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-top: #000000 2px solid;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: bottom; border-top: #000000 2px solid;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom; border-top: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ R. Erik Holmlin, Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td rowspan="2" style="width: 39.08%; vertical-align: middle;">
            <div style="text-align: center;">President, Chief Executive Officer and Director</div>
            <div style="text-align: center; font-style: italic;">(Principal Executive Officer)</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 9, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">R. Erik Holmlin, Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Christopher Stewart</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td rowspan="2" style="width: 39.08%; vertical-align: middle;">
            <div style="text-align: center;">Chief Financial Officer</div>
            <div style="text-align: center; font-style: italic;">(Principal Financial and Accounting Officer)</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 9, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">Christopher Stewart</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ David L. Barker, Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td rowspan="2" style="width: 39.08%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 9, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">David L. Barker, Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Yvonne Linney, Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td rowspan="2" style="width: 39.08%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 9, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">Yvonne Linney, Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Albert A. Luderer, Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td rowspan="2" style="width: 39.08%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 9, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">Albert A. Luderer, Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Hannah Mamuszka</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td rowspan="2" style="width: 39.08%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 9, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">Hannah Mamuszka</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">/s/ Aleksandar Rajkovic, M.D., Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td rowspan="2" style="width: 39.08%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 9, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">Aleksandar Rajkovic, M.D., Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Christopher Twomey</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td rowspan="2" style="width: 39.08%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 9, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">Christopher Twomey</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: top;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Kristiina Vuori, M.D., Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td rowspan="2" style="width: 39.08%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 9, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">Kristiina Vuori, M.D., Ph.D.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 39.08%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Vincent Wong, J.D., M.B.A.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td rowspan="2" style="width: 39.08%; vertical-align: middle;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 9, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 39.08%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">Vincent Wong, J.D., M.B.A.</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 0.7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20.45%; vertical-align: bottom;">&#160;</td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div> <br>
    </div>
    <div>
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"> </div>
  </div>
</body>
</html>
[{"type": "S-8", "sequence": "1", "filename": "brhc10049419_s8.htm", "description": "S-8", "secsgml_size_bytes": 57701}]
{"company-data": {"conformed-name": "Bionano Genomics, Inc.", "cik": "0001411690", "assigned-sic": "3826", "irs-number": "261756290", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-270430", "film-number": "23720744"}, "business-address": {"street1": "9540 TOWNE CENTRE DRIVE", "street2": "SUITE 100", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "(858) 888-7600"}, "mail-address": {"street1": "9540 TOWNE CENTRE DRIVE", "street2": "SUITE 100", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}, "former-company": [{"former-conformed-name": "Bionano Genomics, Inc", "date-changed": "20190308"}, {"former-conformed-name": "BioNano Genomics, Inc", "date-changed": "20120703"}, {"former-conformed-name": "BioNanomatrix Inc", "date-changed": "20070906"}]}
As filed with the Securities and Exchange Commission on March 9, 2023
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Bionano Genomics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
26-1756290
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
9540 Towne Centre Drive, Suite 100
San Diego, California
92121
(Address of Principal Executive Offices)
(Zip Code)
Bionano Genomics, Inc. Amended and Restated 2018 Equity Incentive Plan, as amended
Bionano Genomics, Inc. 2018 Employee Stock Purchase Plan
Bionano Genomics, Inc. 2020 Inducement Plan, as amended
(Full titles of the plans)
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
Bionano Genomics, Inc.
9540 Towne Centre Drive, Suite 100
San Diego, California 92121
(858) 888-7600
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
Thomas A. Coll, Esq.
Phillip S. McGill, Esq.
Cooley LLP
10265 Science Center Drive
San Diego, California 92121
(858) 550-6000
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
Bionano Genomics, Inc.
9540 Towne Centre Drive, Suite 100
San Diego, California 92121
(858) 888-7600
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the
      definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
      provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY NOTE
This Registration Statement on Form S-8 is being filed by Bionano Genomics, Inc. (the "
Registrant
") for the purpose of registering (i) an additional
14,850,682
shares of Registrant's Common Stock, par value $0.0001 per share ("
Common Stock
"), under the Registrant's 2018 Equity Incentive Plan, as amended (the "
2018

        Plan
"), pursuant to the provisions of the 2018 Plan providing for an automatic increase in the number of shares of Common Stock reserved and available for issuance under the 2018 Plan, (ii)
220,000
      additional shares of Common Stock under the Registrant's 2018 Employee Stock Purchase Plan (the "
2018 ESPP
") pursuant to the provisions of the 2018 ESPP providing for an automatic increase
      in the number of shares of Common Stock reserved and available for issuance under the 2018 ESPP, and (iii) 1,000,000 additional shares of Common Stock under the Registrant's 2020 Inducement Plan, as amended (the "
Inducement Plan
"), for an aggregate of 4,100,000 shares of Common Stock issuable under the Inducement Plan, pursuant to an amendment to the Inducement Plan approved by the Board of Directors of the Registrant on November
      21, 2022.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
These additional shares of Common Stock are securities of the same class as other securities for which a Registration Statement of the Registrant on Form S-8 relating to the 2018 Plan, the 2018 ESPP, and the
          Inducement Plan are effective. The Registrant previously registered shares of its Common Stock for issuance under the 2018 Plan and 2018 ESPP under Registration Statements on Form S-8 filed with the Securities and Exchange Commission on
August 28, 2018
(File No. 333-227073),
March 29, 2019
(File No. 333-230589),
March 11, 2020
(File No. 333-237069),
August 14, 2020
(File No. 333-245764),
March 24,
            2021
(File No. 333-254654), and
March 1, 2022
(File No. 333-263176). The Registrant previously registered shares of its Common Stock for
          issuance under the Inducement Plan under Registration Statements on Form S-8 filed with the Securities and Exchange Commission on
August 28, 2020
(File No. 333-248468) and
November 4, 2021
(File No. 333-260762). Pursuant to General Instruction E to Form S-8, this Registration Statement
          hereby incorporates by reference the contents of the Registration Statements referenced above.
Item 8.
Exhibits.
Exhibit
Number
Description
4.1
(1)
Amended and Restated Certificate of Incorporation of the Registrant, as amended
.
4.2
(2)
Amended and Restated Bylaws of the Registrant
.
4.3
(3)
Form of Common Stock Certificate of the Registrant
.
4.4
(4)
Registration Rights Agreement, dated March 14, 2019, by and among the
                  Company and the Innovatus Investors.
5.1
Opinion of Cooley LLP.
23.1
Consent of BDO USA LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Cooley LLP. Reference is made to Exhibit 5.1.
24.1
Power of Attorney. Reference is made to the signature page hereto.
99.1
(5)
Bionano Genomics, Inc. 2018 Equity Incentive Plan, as amended (the "2018 Plan")
.
99.1A
(6)
Forms of grant notice, stock option agreement and notice of exercise under the 2018 Plan.
99.1B
(6)
Forms of director grant notice, stock option agreement and notice of exercise under the 2018 Plan.
99.1C
(6)
Forms of double-trigger grant notice, stock option agreement and notice of exercise under the 2018 Plan.
99.1D
(3)
Forms of international grant notice, stock option agreement and
                  notice of exercise under the 2018 Plan.
99.1E
(7)
Forms of restricted stock unit grant notice and restricted stock unit award agreement under the 2018
                  Plan.
99.2
(8)
Bionano Genomics, Inc. 2018 Employee Stock Purchase Plan
.
99.3
(9)
Bionano Genomics, Inc. 2020 Inducement Plan, as amended
.
99.3A
(10)
Form of Stock Option Grant Notice and Stock Option Agreement under the Bionano Genomics, Inc. 2020 Inducement Plan, as amended
.
107
Filing Fee Table.
(1)
Incorporated by reference to the Registrant's Annual Report on Form 10-K, filed with the SEC on March 23, 2021.
(2)
Incorporated by reference to the Registrant's Current Report on Form 8-K, filed with the SEC on August 24, 2018.
(3)
Incorporated by reference to the Registrant's Registration Statement on Form S-1 (File No. 333-225970), as amended.
(4)
Incorporated by reference to the Registrant's Current Report on Form 8-K, filed with the SEC on March 14, 2019.
(5)
Incorporated by reference to the Registrant's Registration Statement on Form S-8 (File No. 333-245764).
(6)
Incorporated by reference to the Registrant's Annual Report on Form 10-K, filed with the SEC on March 9, 2023.
(7)
Incorporated by reference to the Registrant's Quarterly Report on Form 10-Q, filed with the SEC on
August 4,
2021.
(8)
Incorporated by reference to the Registrant's Registration Statement on Form S-8 (File No. 333-227073).
(9)
Incorporated by reference to the Registrant's Current Report on Form 8-K, filed with the SEC on November 28, 2022
(10)
Incorporated by reference to the Registrant's Current Report on Form 8-K, filed with the SEC on August 24, 2020.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
      S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on March 9, 2023.
BIONANO GENOMICS, INC.
By:
/s/ R. Erik Holmlin, Ph.D.
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints each of R. Erik Holmlin, Ph.D. and Christopher Stewart as his or her true and lawful
      attorney-in-fact and agent, with the full power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments),
      and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and
      thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or
      substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ R. Erik Holmlin, Ph.D.
President, Chief Executive Officer and Director
(Principal Executive Officer)
March 9, 2023
R. Erik Holmlin, Ph.D.
/s/ Christopher Stewart
Chief Financial Officer
(Principal Financial and Accounting Officer)
March 9, 2023
Christopher Stewart
/s/ David L. Barker, Ph.D.
Director
March 9, 2023
David L. Barker, Ph.D.
/s/ Yvonne Linney, Ph.D.
Director
March 9, 2023
Yvonne Linney, Ph.D.
/s/ Albert A. Luderer, Ph.D.
Director
March 9, 2023
Albert A. Luderer, Ph.D.
/s/ Hannah Mamuszka
Director
March 9, 2023
Hannah Mamuszka
/s/ Aleksandar Rajkovic, M.D., Ph.D.
Director
March 9, 2023
Aleksandar Rajkovic, M.D., Ph.D.
/s/ Christopher Twomey
Director
March 9, 2023
Christopher Twomey
/s/ Kristiina Vuori, M.D., Ph.D.
Director
March 9, 2023
Kristiina Vuori, M.D., Ph.D.
/s/ Vincent Wong, J.D., M.B.A.
Director
March 9, 2023
Vincent Wong, J.D., M.B.A.