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  <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on March 9, 2023</div>
  <div style="text-align: center; font-size: 14pt; font-weight: bold;">
    <div style="font-size: 10pt; font-weight: bold;">Registration No. 333-</div>
    <div>
      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;"></div>
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  <div style="text-align: center; font-weight: bold;">
    <div style="font-size: 14pt;">UNITED STATES</div>
    <font style="font-size: 14pt;"> </font></div>
  <font style="font-size: 14pt;"> </font>
  <div style="text-align: center; font-weight: bold; font-size: 14pt;">SECURITIES AND EXCHANGE COMMISSION</div>
  <div style="text-align: center; font-weight: bold; font-size: 12pt;">Washington, D.C.&#160; 20549</div>
  <div style="text-align: center; font-weight: bold;"> <br>
  </div>
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  <div style="text-align: center; font-weight: bold;"> <br>
  </div>
  <div style="text-align: center; font-weight: bold; font-size: 18pt;">FORM S-8</div>
  <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
  <div style="text-align: center; font-weight: bold;">UNDER THE SECURITIES ACT OF 1933</div>
  <div style="text-align: center; font-weight: bold;"> <br>
  </div>
  <div>
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  <div style="text-align: center; font-weight: bold;"> <br>
  </div>
  <div style="text-align: center; font-weight: bold; font-size: 24pt;">GH Research PLC</div>
  <div style="text-align: center; font-weight: bold;">(Exact Name of Registrant as specified in its charter)</div>
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      <tr>
        <td style="width: 33%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">Ireland</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 33%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">N/A</div>
        </td>
      </tr>
      <tr>
        <td style="width: 33%; vertical-align: top;">
          <div style="text-align: center;">(State or other jurisdiction of incorporation or organization)</div>
        </td>
        <td style="width: 34%; vertical-align: top;">&#160;</td>
        <td style="width: 33%; vertical-align: top;">
          <div style="text-align: center;">(I.R.S. Employer Identification No.)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 33%; vertical-align: top;">&#160;</td>
        <td style="width: 34%; vertical-align: top;">
          <div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">GH Research PLC</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Joshua Dawson House</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Dawson Street</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Dublin 2</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">D02 RY95</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Ireland</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Tel: +353 1 437 8334</div>
          </div>
        </td>
        <td style="width: 33%; vertical-align: top;">&#160;</td>
      </tr>

  </table>
  <br>
  <div>
    <div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
        <div style="font-weight: normal;">(Address, including zip code, and telephone number, including area code, of Principal Executive Offices)</div>
        <div style="font-weight: normal;"> <br>
        </div>
        <div>
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      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;"> </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">GH Research PLC Share Option Plan</div>
      <div style="text-align: center; color: #000000; font-weight: bold;"> <font style="font-weight: normal;">(Full title of the plan)</font></div>
      <div style="text-align: center; color: #000000; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
        <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 18%; color: #000000;"></div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Cogency Global Inc.</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">122 East 42<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup> Street, 18<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">New York, NY 10168</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Tel: (800) 221-0102</div>
      <div style="text-align: center; color: #000000; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;"> <font style="font-weight: normal;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</font></div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><font style="font-weight: normal;"> <br>
        </font></div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
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        <div style="margin-right: 36pt; margin-left: 36pt;"><font style="font-weight: bold;"> <br>
          </font></div>
        <div style="color: #000000; font-weight: bold;"><font style="font-weight: bold;">Copies to</font>:<br>
          <div style="font-weight: normal;">Adam Kaminsky</div>
          <font style="font-weight: normal;"> </font>
          <div style="font-weight: normal;">Davis Polk &amp; Wardwell LLP</div>
          <font style="font-weight: normal;"> </font>
          <div style="font-weight: normal;">450 Lexington Avenue</div>
          <font style="font-weight: normal;"> </font>
          <div style="font-weight: normal;">New York, NY 10017</div>
          <font style="font-weight: normal;"> </font>
          <div style="font-weight: normal;">(212) 450-4000</div>
          <div> <br>
          </div>
        </div>
      </div>
    </div>
  </div>
  <div style="text-align: center; font-weight: bold;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions
    of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
  <div><br>
  </div>
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      <tr>
        <td style="width: 60%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">Large accelerated filer &#9744;</div>
        </td>
        <td style="width: 40%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">Accelerated filer &#9746;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 60%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">Non-accelerated filer <a name="Check2"></a> &#9744; (Do not check if a smaller reporting company)</div>
        </td>
        <td style="width: 40%; vertical-align: top;">
          <div style="text-align: center; font-weight: bold;">Smaller reporting company &#9744;<a name="Check4"></a></div>
        </td>
      </tr>
      <tr>
        <td style="width: 60%; vertical-align: top; text-align: center;" rowspan="1" colspan="2"><font style="font-weight: bold;">Emerging Growth Company</font> <font style="font-weight: bold;">&#9746;</font></td>
      </tr>

  </table>
  <div style="text-align: center; margin-left: 27.5pt; font-weight: bold;"><br>
  </div>
  <div style="text-align: center; font-weight: bold;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
    provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
  <div style="text-align: center; font-weight: bold;"> <br>
  </div>
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  </div>
  <div style="text-align: center; text-indent: 18pt; font-weight: bold;">PART I</div>
  <div>&#160;</div>
  <div style="text-align: center; text-indent: 18pt; font-weight: bold;">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">The documents containing the information specified in Item 1 and Item 2 of Part I of Form S-8 will be sent or given to participants as specified by Rule 428(b)(1) under the Securities Act of 1933, as
    amended (the &#8220;Securities Act&#8221;).&#160; In accordance with the rules and regulations of the U.S. Securities and Exchange Commission (the &#8220;Commission&#8221;) and the instructions to Form S-8, such documents are not being filed with the Commission either as part of
    this Registration Statement on Form S-8 (this &#8220;Registration Statement&#8221;) or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act. </div>
  <div><br>
  </div>
  <div style="text-align: center; text-indent: 18pt; font-weight: bold;">PART II</div>
  <div>&#160;</div>
  <div style="text-align: center; text-indent: 18pt; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
  <div>&#160;</div>
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      <tr>
        <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 3.</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Incorporation of Documents by Reference.</div>
        </td>
      </tr>

  </table>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">The following documents are incorporated herein by reference:</div>
  <div style="text-indent: 18pt;">&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;"><a name="P175057497"></a>(a) The annual report on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001855129/000114036123010814/brhc10049341_20f.htm">Form 20-F</a> of GH Research PLC (the
    &#8220;Registrant&#8221;) for the fiscal year ended December 31, 2022, filed with the Commission on March 9, 2023; and</div>
  <div><br>
  </div>
  <div style="text-align: justify; text-indent: 18pt;">(b) The description of the Registrant&#8217;s share capital which is contained in the Registrant&#8217;s Registration Statement on <a href="https://www.sec.gov/Archives/edgar/data/1855129/000114036121021842/nt10022430x7_8a12b.htm">Form 8-A (Registration No. 001-40530)</a>, dated June 22, 2021, including any amendments or supplements thereto.</div>
  <div style="text-indent: 18pt;">&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">In addition, all documents subsequently filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
    amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, including any Reports of Foreign Private Issuers on Form 6-K submitted during such period (or
    portion thereof) that is identified in such form as being incorporated by reference into this Registration Statement, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing of
    such documents. The Registrant is not incorporating by reference any documents or portions thereof, whether specifically listed above or filed in the future, that are not deemed &#8220;filed&#8221; with the Commission.</div>
  <div style="text-indent: 18pt;">&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the
    extent that a statement contained herein, (or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement so modified or superseded
    shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</div>
  <div>&#160;</div>
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        <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 4.</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Description of Securities.</div>
        </td>
      </tr>

  </table>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">Not applicable.</div>
  <div>&#160;</div>
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      <tr>
        <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 5.</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Interests of Named Experts and Counsel.</div>
        </td>
      </tr>

  </table>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">Not applicable.</div>
  <div>&#160;</div>
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      <tr>
        <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 6.</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Indemnification of Directors and Officers.</div>
        </td>
      </tr>

  </table>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">To the fullest extent permitted by Irish law, the Registrant&#8217;s constitution (&#8220;Constitution&#8221;) confers an indemnity on the Registrant&#8217;s directors and officers. However, this indemnity is limited by the
    Irish Companies Act 2014 (the "Irish Companies Act"), which prescribes that an advance commitment to indemnify only permits a company to pay the costs or discharge the liability of a director or corporate secretary where judgment is given in favor of
    the director or corporate secretary in any civil or criminal action in respect of such costs or liability, or where an Irish court grants relief because the director or corporate secretary acted honestly and reasonably and ought fairly to be excused.
    Any provision whereby an Irish company seeks to commit in advance to indemnify its directors or corporate secretary over and above the limitations imposed by the Irish Companies Act will be void under Irish law, whether contained in the company&#8217;s
    constitution or any contract between the company and the director or corporate secretary. This restriction does not apply to the Registrant&#8217;s executives who are not directors or other persons who would not be considered &#8220;officers&#8221; within the meaning of
    that term under the Irish Companies Act.</div>
  <div>&#160;</div>
  <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
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  </div>
  <div style="text-align: justify; text-indent: 18pt;">The Registrant&#8217;s Constitution also contains indemnification and expense advancement provisions for persons who are not directors or our corporate secretary.</div>
  <div style="text-indent: 18pt;">&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">The Registrant maintains directors&#8217; and officers&#8217; liability insurance, as well as other types of insurance, for its directors, officers, employees and agents, which is permitted under the Constitution
    and the Irish Companies Act.</div>
  <div>&#160;</div>
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        <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 7.</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Exemption from Registration Claimed.</div>
        </td>
      </tr>

  </table>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">Not applicable.</div>
  <div>&#160;</div>
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        <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 8.</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Exhibits.</div>
        </td>
      </tr>

  </table>
  <div>&#160;</div>
  <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="za25815cc3c724e26af266ba959c540e5">

      <tr>
        <td style="width: 8%; vertical-align: top;" rowspan="1">
          <div style="text-align: justify;">Exhibit</div>
          <div style="text-align: justify;"><u>Number</u></div>
        </td>
        <td style="width: 92%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;"><a href="https://www.sec.gov/Archives/edgar/data/1855129/000114036123010814/brhc10049341_ex1-1.htm">4</a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;">Constitution of GH Research PLC (incorporated herein by reference to Exhibit 1.1 of the</div>
          <div style="text-align: justify;">Registrant&#8217;s Annual Report on Form 20-F for the fiscal year ended December 31, 2022, filed with the Commission on March 9, 2023).</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;"><a href="brhc10049439_ex5.htm">5</a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;">Opinion of A&amp;L Goodbody LLP (filed herewith)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;"><a href="brhc10049439_ex5.htm">23.1</a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;">Consent of A&amp;L Goodbody LLP (included in Exhibit 5)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;"><a href="brhc10049439_ex23-2.htm">23.2</a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;">Consent of PricewaterhouseCoopers, an independent registered public accounting firm (filed herewith)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;"><a href="brhc10049439_ex23-3.htm">23.3</a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;">Consent of PricewaterhouseCoopers SA, an independent registered public accounting firm (filed herewith)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;"><a href="#POWEROFATTORNEY">24</a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;">Powers of Attorney (included in the signature pages hereto)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;"><a href="brhc10049439_ex99.htm">99</a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;">GH Research PLC Share Option Plan (filed herewith)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;"><a href="brhc10049439_ex107.htm">107</a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: justify;">Filing Fee Table</div>
        </td>
      </tr>

  </table>
  <div> <br>
  </div>
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  </div>
  <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z9d7eab2a88c74ec5957cf6ebabe80b84">

      <tr>
        <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 9.</td>
        <td style="width: auto; vertical-align: top; text-align: justify;">
          <div style="font-weight: bold;">Undertakings.</div>
        </td>
      </tr>

  </table>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">(a)&#160;&#160; The undersigned Registrant hereby undertakes:</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt; margin-left: 18pt;">(1)&#160; To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt; margin-left: 36pt;">(i)&#160;&#160; To include any prospectus required by Section 10(a)(3) of the Securities Act;</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt; margin-left: 36pt;">(ii)&#160; To reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which,
    individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
    securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
    aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective Registration Statement;</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt; margin-left: 36pt;">(iii)&#160; To include any material information with respect to the Plan not previously disclosed in this Registration Statement or any material change to such information in this
    Registration Statement;</div>
  <div>&#160;</div>
  <div style="text-align: justify; margin-left: 18pt;"><font style="font-style: italic;">provided</font>, <font style="font-style: italic;">however</font>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in
    a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration
    Statement.</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt; margin-left: 18pt;">(2)&#160; That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to
    the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof.</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt; margin-left: 18pt;">(3)&#160; To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">(b)&#160; The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&#8217;s annual report pursuant to Section 13(a) or
    15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration Statement shall be deemed to be a new
    registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof.</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">(c)&#160;&#160; Insofar as indemnification of liabilities arising under the Securities Act may be permitted to directors or persons controlling the Registrant pursuant to the foregoing provisions, the Registrant
    has been informed that, in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.&#160; In the event that a claim for indemnification against such liabilities (other
    than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in
    connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by
    it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</div>
  <div>&#160;</div>
  <div></div>
  <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
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  </div>
  <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
  <div>&#160;</div>
  <div style="text-align: justify; text-indent: 18pt;">Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this Registration Statement and
    has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Dublin, Ireland, on this 9<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> day of March, 2023.</div>
  <div>&#160;</div>
  <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z10d9b1b64d874be19d1ee99af8c7d6a9">

      <tr>
        <td colspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
        <td colspan="2" style="vertical-align: top;">
          <div style="text-align: justify;">GH Research PLC</div>
        </td>
      </tr>
      <tr>
        <td colspan="1" style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
        <td colspan="2" style="vertical-align: top;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;" colspan="1">&#160;</td>
        <td style="width: 5%; vertical-align: top;">
          <div style="text-align: justify;">By:</div>
        </td>
        <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">/s/ Julie Ryan</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;" colspan="1">&#160;</td>
        <td style="width: 5%; vertical-align: top;">
          <div style="text-align: justify;">Name:</div>
        </td>
        <td style="width: 45%; vertical-align: top;">
          <div style="text-align: justify; color: rgb(0, 0, 0);">Julie Ryan</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;" colspan="1">&#160;</td>
        <td style="width: 5%; vertical-align: top;">
          <div style="text-align: justify;">Title:</div>
        </td>
        <td style="width: 45%; vertical-align: top;">
          <div style="text-align: justify;">Vice President, Finance</div>
        </td>
      </tr>

  </table>
  <div> <br>
  </div>
  <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
    <div style="page-break-after: always;" class="BRPFPageBreak">
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  </div>
  <div style="text-align: center; font-weight: bold;">POWER OF ATTORNEY<a name="POWEROFATTORNEY"><!--Anchor--></a></div>
  <div><br>
  </div>
  <div>
    <div style="text-align: justify; text-indent: 42.85pt; color: rgb(0, 0, 0);">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Theis Terwey and Julie Ryan, either of whom may act without the
      joinder of the other, as his or her true and lawful attorneys-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments
      (including post-effective amendments) to this Registration Statement and any and all additional registration statements pursuant to Rule 462(b) of the Securities Act and to file the same, with all exhibits thereto, and all other documents in
      connection therewith, with the Commission, granting unto said attorneys-in-fact and agent full power and authority to do and perform each and every act in person, hereby ratifying and confirming all that said attorney-in-fact and agent or his
      substitutes may lawfully do or cause to be done by virtue hereof.</div>
  </div>
  <div style="text-align: justify;"><br>
  </div>
  <div>
    <div></div>
    <div style="text-align: justify; text-indent: 42.85pt; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</div>
    <div>&#160;</div>
    <div></div>
  </div>
  <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="za085e67ac7894600b0cc36eebbe59ab4">

      <tr>
        <td style="width: 38%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0) rgb(0, 0, 0) rgb(0, 0, 0);">
          <div style="text-align: justify; font-weight: bold;"><u>Signature</u></div>
        </td>
        <td style="width: 1.74%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0) rgb(0, 0, 0) rgb(0, 0, 0);">&#160;</td>
        <td style="width: 40.35%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0) rgb(0, 0, 0) rgb(0, 0, 0);">
          <div style="text-align: justify; font-weight: bold;"><u>Title</u></div>
        </td>
        <td style="width: 20%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0) rgb(0, 0, 0) rgb(0, 0, 0);">
          <div style="text-align: justify; font-weight: bold;"><u>Date</u></div>
        </td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">/s/ Theis Terwey</div>
        </td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">Chief Executive Officer</div>
        </td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">March 9, 2023</div>
        </td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify; color: rgb(0, 0, 0);">Theis Terwey</div>
        </td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">(Principal Executive Officer)</div>
        </td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">/s/ Julie Ryan</div>
        </td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">Vice President, Finance</div>
        </td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">March 9, 2023</div>
        </td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify; color: rgb(0, 0, 0);">Julie Ryan</div>
        </td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">&#160;(Principal Financial Officer and Principal Accounting Officer)</div>
        </td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">/s/ Florian Sch&#246;nharting</div>
        </td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">Director</div>
        </td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">March 9, 2023</div>
        </td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;"><font style="color: rgb(0, 0, 0);">Florian Sch</font>&#246;n<font style="color: rgb(0, 0, 0);">harting</font></div>
        </td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">/s/ Michael Forer</div>
        </td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">Director</div>
        </td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;">March 9, 2023</div>
        </td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify; color: rgb(0, 0, 0);">Michael Forer</div>
        </td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify; color: rgb(0, 0, 0);"><br>
          </div>
        </td>
        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;"><br>
          </div>
        </td>
        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="text-align: justify;"><br>
          </div>
        </td>
      </tr>
      <tr>
        <td style="width: 38%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" rowspan="1">/s/ Dermot Hanley</td>
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        <td style="width: 40.35%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" rowspan="1">Director</td>
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        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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        <td style="width: 1.74%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;</td>
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      <tr>
        <td style="width: 38%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
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        <td style="width: 20%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
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  <div style="text-align: center; font-weight: bold;">SIGNATURE OF AUTHORIZED REPRESENTATIVE IN THE UNITED STATES</div>
  <div>&#160;</div>
  <div>Pursuant to the Securities Act of 1933, as amended, the undersigned, the duly authorized representative in the United States of America, has signed this registration statement thereto in New York, NY on March 9, 2023.</div>
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            <div>&#160;</div>
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            <div style="text-align: left; font-weight: bold;">Authorized U.S. Representative--Cogency Global Inc.</div>
          </td>
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          <td style="width: 4%; text-align: right; vertical-align: bottom;" rowspan="1">By:</td>
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          <td style="width: 30%; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;/s/ Colleen A. De Vries</td>
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          <td style="width: 30%;" rowspan="1">Name: Colleen A. De Vries</td>
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          <td style="width: 30%;" rowspan="1">Title: Senior Vice-President on behalf of Cogency Global Inc.</td>
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{"company-data": {"conformed-name": "GH Research PLC", "cik": "0001855129", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "L2", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-270422", "film-number": "23720455"}, "business-address": {"street1": "JOSHUA DAWSON HOUSE", "street2": "DAWSON STREET", "city": "DUBLIN 2", "state": "L2", "zip": "D02 RY95", "phone": "353 1 437 8334"}, "mail-address": {"street1": "JOSHUA DAWSON HOUSE", "street2": "DAWSON STREET", "city": "DUBLIN 2", "state": "L2", "zip": "D02 RY95"}}
As filed with the Securities and Exchange Commission on March 9, 2023
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
FORM S-8
REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OF 1933
GH Research PLC
(Exact Name of Registrant as specified in its charter)
Ireland
N/A
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
GH Research PLC
Joshua Dawson House
Dawson Street
Dublin 2
D02 RY95
Ireland
Tel: +353 1 437 8334
(Address, including zip code, and telephone number, including area code, of Principal Executive Offices)
GH Research PLC Share Option Plan
(Full title of the plan)
Cogency Global Inc.
122 East 42
nd
Street, 18
th
Floor
New York, NY 10168
Tel: (800) 221-0102
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to
:
Adam Kaminsky
Davis Polk & Wardwell LLP
450 Lexington Avenue
New York, NY 10017
(212) 450-4000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions
    of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☐
Accelerated filer ☒
Non-accelerated filer
☐ (Do not check if a smaller reporting company)
Smaller reporting company ☐
Emerging Growth Company
☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
    provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
The documents containing the information specified in Item 1 and Item 2 of Part I of Form S-8 will be sent or given to participants as specified by Rule 428(b)(1) under the Securities Act of 1933, as
    amended (the "Securities Act").  In accordance with the rules and regulations of the U.S. Securities and Exchange Commission (the "Commission") and the instructions to Form S-8, such documents are not being filed with the Commission either as part of
    this Registration Statement on Form S-8 (this "Registration Statement") or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The following documents are incorporated herein by reference:
(a) The annual report on
Form 20-F
of GH Research PLC (the
    "Registrant") for the fiscal year ended December 31, 2022, filed with the Commission on March 9, 2023; and
(b) The description of the Registrant's share capital which is contained in the Registrant's Registration Statement on
Form 8-A (Registration No. 001-40530)
, dated June 22, 2021, including any amendments or supplements thereto.
In addition, all documents subsequently filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective
    amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, including any Reports of Foreign Private Issuers on Form 6-K submitted during such period (or
    portion thereof) that is identified in such form as being incorporated by reference into this Registration Statement, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing of
    such documents. The Registrant is not incorporating by reference any documents or portions thereof, whether specifically listed above or filed in the future, that are not deemed "filed" with the Commission.
Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the
    extent that a statement contained herein, (or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement so modified or superseded
    shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4.
Description of Securities.
Not applicable.
Item 5.
Interests of Named Experts and Counsel.
Not applicable.
Item 6.
Indemnification of Directors and Officers.
To the fullest extent permitted by Irish law, the Registrant's constitution ("Constitution") confers an indemnity on the Registrant's directors and officers. However, this indemnity is limited by the
    Irish Companies Act 2014 (the "Irish Companies Act"), which prescribes that an advance commitment to indemnify only permits a company to pay the costs or discharge the liability of a director or corporate secretary where judgment is given in favor of
    the director or corporate secretary in any civil or criminal action in respect of such costs or liability, or where an Irish court grants relief because the director or corporate secretary acted honestly and reasonably and ought fairly to be excused.
    Any provision whereby an Irish company seeks to commit in advance to indemnify its directors or corporate secretary over and above the limitations imposed by the Irish Companies Act will be void under Irish law, whether contained in the company's
    constitution or any contract between the company and the director or corporate secretary. This restriction does not apply to the Registrant's executives who are not directors or other persons who would not be considered "officers" within the meaning of
    that term under the Irish Companies Act.
The Registrant's Constitution also contains indemnification and expense advancement provisions for persons who are not directors or our corporate secretary.
The Registrant maintains directors' and officers' liability insurance, as well as other types of insurance, for its directors, officers, employees and agents, which is permitted under the Constitution
    and the Irish Companies Act.
Item 7.
Exemption from Registration Claimed.
Not applicable.
Item 8.
Exhibits.
Exhibit
Number
4
Constitution of GH Research PLC (incorporated herein by reference to Exhibit 1.1 of the
Registrant's Annual Report on Form 20-F for the fiscal year ended December 31, 2022, filed with the Commission on March 9, 2023).
5
Opinion of A&L Goodbody LLP (filed herewith)
23.1
Consent of A&L Goodbody LLP (included in Exhibit 5)
23.2
Consent of PricewaterhouseCoopers, an independent registered public accounting firm (filed herewith)
23.3
Consent of PricewaterhouseCoopers SA, an independent registered public accounting firm (filed herewith)
24
Powers of Attorney (included in the signature pages hereto)
99
GH Research PLC Share Option Plan (filed herewith)
107
Filing Fee Table
Item 9.
Undertakings.
(a)   The undersigned Registrant hereby undertakes:
(1)  To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)   To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)  To reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which,
    individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
    securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
    aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective Registration Statement;
(iii)  To include any material information with respect to the Plan not previously disclosed in this Registration Statement or any material change to such information in this
    Registration Statement;
provided
,
however
, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in
    a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration
    Statement.
(2)  That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to
    the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(3)  To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)  The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or
    15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration Statement shall be deemed to be a new
    registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(c)   Insofar as indemnification of liabilities arising under the Securities Act may be permitted to directors or persons controlling the Registrant pursuant to the foregoing provisions, the Registrant
    has been informed that, in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.  In the event that a claim for indemnification against such liabilities (other
    than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in
    connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by
    it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this Registration Statement and
    has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Dublin, Ireland, on this 9
th
day of March, 2023.
GH Research PLC
By:
/s/ Julie Ryan
Name:
Julie Ryan
Title:
Vice President, Finance
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Theis Terwey and Julie Ryan, either of whom may act without the
      joinder of the other, as his or her true and lawful attorneys-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments
      (including post-effective amendments) to this Registration Statement and any and all additional registration statements pursuant to Rule 462(b) of the Securities Act and to file the same, with all exhibits thereto, and all other documents in
      connection therewith, with the Commission, granting unto said attorneys-in-fact and agent full power and authority to do and perform each and every act in person, hereby ratifying and confirming all that said attorney-in-fact and agent or his
      substitutes may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Theis Terwey
Chief Executive Officer
March 9, 2023
Theis Terwey
(Principal Executive Officer)
/s/ Julie Ryan
Vice President, Finance
March 9, 2023
Julie Ryan
(Principal Financial Officer and Principal Accounting Officer)
/s/ Florian Schönharting
Director
March 9, 2023
Florian Sch
ön
harting
/s/ Michael Forer
Director
March 9, 2023
Michael Forer
/s/ Dermot Hanley
Director
March 9, 2023
Dermot Hanley
/s/ Duncan Moore
Director
March 9, 2023
Duncan Moore
SIGNATURE OF AUTHORIZED REPRESENTATIVE IN THE UNITED STATES
Pursuant to the Securities Act of 1933, as amended, the undersigned, the duly authorized representative in the United States of America, has signed this registration statement thereto in New York, NY on March 9, 2023.
Authorized U.S. Representative--Cogency Global Inc.
By:
/s/ Colleen A. De Vries
Name: Colleen A. De Vries
Title: Senior Vice-President on behalf of Cogency Global Inc.