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    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">As filed with the Securities and Exchange Commission on March 20, 2025</div>
    <div style="text-align: right; margin-right: 36pt; color: rgb(0, 0, 0); font-weight: bold;">Registration No. 333-</div>
    <div style="text-align: center; color: #000000; font-size: 14pt; font-weight: bold;">
      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;"></div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">WASHINGTON, D.C.&#160; 20549</div>
    <div>
      <div>&#160;
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    <div>&#160;</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
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      <div style="text-align: center; margin-right: 216pt; margin-left: 216pt;"><font style="color: rgb(0, 0, 0);"> </font><br>
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    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;">Gyre Therapeutics, Inc.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
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            <div style="text-align: center; color: #000000; font-weight: bold;">Delaware</div>
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          <td colspan="1" rowspan="1" style="width: 2%; vertical-align: top;"><br>
          </td>
          <td rowspan="1" style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-weight: bold;">56-2020050</div>
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          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or Other Jurisdiction of</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Incorporation or Organization)</div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top;"><br>
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            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Identification No.)</div>
          </td>
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    <div style="text-align: center; color: #000000; font-weight: bold;">Gyre Therapeutics, Inc.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">12770 High Bluff Drive, Suite 150</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">San Diego, California 92130</div>
    <div style="text-align: center; color: rgb(0, 0, 0);">(Address, including zip code, of registrant&#8217;s principal executive offices)</div>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan</div>
    <div style="text-align: center; color: rgb(0, 0, 0);">(Full title of the plan)</div>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Han Ying, Ph.D.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Chief Executive Officer</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Gyre Therapeutics, Inc.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">12770 High Bluff Drive, Suite 150</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">San Diego, California 92130</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(858) 567-7770</div>
    <div style="text-align: center; color: rgb(0, 0, 0);">&#160;(Name, address and telephone number (including area code) of agent for service)</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0);">Copy to:</div>
    <div>&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Sean Feller</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Gibson, Dunn &amp; Crutcher LLP</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">2029 Century Park East, Suite 4000</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Los Angeles, CA 90067-3026</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(310) 552-8500</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
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      <div style="text-align: center; margin-right: 216pt; margin-left: 216pt;"><font style="color: rgb(0, 0, 0);"> </font>
        <hr noshade="noshade" align="" style="border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none;"></div>
    </div>
    <div style="color: #000000;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated
      filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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          <td style="width: 25%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Large accelerated filer</div>
          </td>
          <td style="width: 25%; vertical-align: bottom;">&#9744;</td>
          <td style="width: 25%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Accelerated filer</div>
          </td>
          <td style="width: 25%; vertical-align: bottom;">&#9746;</td>
        </tr>
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          <td style="width: 25%; vertical-align: middle;">&#160;</td>
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            <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
          </td>
          <td style="width: 25%; vertical-align: bottom;">&#9744;</td>
          <td style="width: 25%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Smaller reporting company</div>
          </td>
          <td style="width: 25%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">&#9746;</div>
          </td>
        </tr>
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          </td>
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          <td style="width: 25%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Emerging growth company</div>
          </td>
          <td style="width: 25%; vertical-align: bottom;">&#9744;</td>
        </tr>
        <tr>
          <td colspan="4" style="vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided
              pursuant to Section 7(a)(2)(B) of the Securities Act.&#160; &#9744;</div>
          </td>
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      <div><font style="color: rgb(0, 0, 0);"> </font><br>
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    <div style="text-align: center; color: #000000; font-weight: bold;">EXPLANATORY NOTE</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;"><font style="color: #000000;">This Registration Statement on Form S-8 (this &#8220;Registration Statement&#8221;) is being filed pursuant to General Instruction E to Form S-8 for the purpose of registering an additional 4,315,377
        shares of common stock, par value $0.001 per share, of Gyre Therapeutics, Inc., a Delaware corporation (the "Registrant&#8221;) under the Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan (the &#8220;Plan&#8221;), pursuant to the provisions of the Plan providing
        for an automatic increase in the number of shares reserved and available for issuance under the Plan on January 1, 2025. In accordance with General Instruction E to Form S-8, this Registration Statement hereby incorporates by reference the contents
        of the Registrant&#8217;s Registration Statements on Form S-8 filed by the Company with respect to the Plan on October 31, 2023 (</font><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050314/ny20009756x9_s8.htm">SEC File No.
        333-275222</a><font style="color: rgb(0, 0, 0);">) and March 28, 2024 (</font><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036124015774/ef20025363_s8.htm">SEC File No. 333-278291</a><font style="color: rgb(0, 0, 0);">), together
        with all exhibits filed therewith or incorporated therein by reference.</font></div>
    <div>&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">PART II</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div>&#160;</div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="z10ab8e3d025c4d79960bd32b9417be56" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;">

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            <td nowrap="nowrap" style="text-align: right; vertical-align: top; width: 36pt;">
              <div style="text-align: left; color: #000000; font-weight: bold;">Item 8. <br>
              </div>
            </td>
            <td style="text-align: left; vertical-align: top; width: auto;">
              <div style="color: #000000; font-weight: bold;">Exhibits.</div>
            </td>
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      </table>
    </div>
    <div><br>
    </div>
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        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);"><u>Exhibit No.</u></div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);"><u>Exhibit Description</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">4.1</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="color: rgb(0, 0, 255);"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000095017024126306/gyre-ex3_1.htm">Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the
                Registrant&#8217;s Quarterly Report on Form 10-Q filed on November 13, 2024).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">4.2</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="color: rgb(0, 0, 238);"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036122046943/brhc10045912_ex3-1.htm">Certificate of Designation of Preferences, Rights and Limitations of Series X Convertible Preferred Stock
                (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on December 27, 2022).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">4.3</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="color: rgb(0, 0, 238);"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex3-2.htm">Amendment to Certificate of Designation of Preferences, Rights and Limitations of Series X Convertible
                Preferred Stock (incorporated by reference to Exhibit 3.2 to the Registrant&#8217;s Current Report on Form 8-K filed on October 30, 2023).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">4.4</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="color: rgb(0, 0, 238);"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123030517/brhc20054638_ex3-1.htm">Certificate of Designation of Preferences, Rights and Limitations of Series Y Preferred Stock (incorporated
                by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on June 20, 2023).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">4.5</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="color: rgb(0, 0, 238);"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123042067/brhc20058284_ex3-1.htm">Certificate of Elimination of Series Y Preferred Stock (incorporated by reference to Exhibit 3.1 to the
                Registrant&#8217;s Current Report on Form 8-K filed on August 31, 2023).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">4.6</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="color: rgb(0, 0, 238);"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312517121994/d375894dex31.htm">Certificate of Designation of Preferences, Rights and Limitations of Series A Convertible Preferred Stock
                (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on April 13, 2017).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">4.7</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="color: rgb(0, 0, 238);"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000095017024037242/gyre-ex3_6b.htm">Certificate of Elimination of Series A Preferred Stock (incorporated by reference to Exhibit 3.6(b) to the
                Registrant&#8217;s Annual Report on Form 10-K filed on March 27, 2024).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">4.8</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="color: rgb(0, 0, 238);"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex3-3.htm">Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Registrant&#8217;s
                Current Report on Form 8-K filed on October 30, 2023).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">5.1*</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div><a href="ef20045895_ex5-1.htm">Opinion of Gibson, Dunn &amp; Crutcher LLP.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">23.1*</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div><a href="ef20045895_ex23-1.htm">Consent of Grant Thornton Zhitong Certified Public Accountants LLP.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">23.2*</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div><a href="ef20045895_ex5-1.htm">Consent of Gibson, Dunn &amp; Crutcher LLP (included in Exhibit 5.1).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">24.1*</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="text-align: justify;"><a href="#Signature">Power of Attorney (included on the signature page hereto).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">99.1</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="text-align: justify; color: rgb(0, 0, 238);"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex10-2.htm">Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan (incorporated by reference to
                Exhibit 10.2 to the Registrant&#8217;s Current Report on Form 8-K filed on October 30, 2023).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">107.1*</div>
          </td>
          <td style="width: 92%; vertical-align: top;">
            <div style="text-align: justify;"><a href="ef20045895_ex107-1.htm">Filing Fee Table.</a></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify; color: #000000;">
      <hr noshade="noshade" align="left" style="height: 2px; width: 10%; color: #000000; background-color: #000000; text-align: left; margin-left: 0px; margin-right: auto; border: none;"></div>
    <div style="color: #000000;">*Filed herewith.</div>
    <div style="color: #000000;"> <br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
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    <div style="text-align: center; color: #000000; font-weight: bold;">SIGNA<a name="Signature"></a>TURES</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt; color: #000000;">Pursuant to the requirements of the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
      filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on March 20, 2025.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zeb0004f186184d1cac028889f6fa10ab">

        <tr>
          <td colspan="1" style="width: 50%; vertical-align: top;"><br>
          </td>
          <td colspan="2" style="vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Gyre Therapeutics, Inc.</div>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 50%; vertical-align: top;"><br>
          </td>
          <td style="width: 5%; vertical-align: top;"><br>
          </td>
          <td style="width: 45%; vertical-align: top;"><br>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 50%; vertical-align: top;"><br>
          </td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">By:</div>
          </td>
          <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0);">/s/ Han Ying, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 50%; vertical-align: top;"><br>
          </td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Name:</div>
          </td>
          <td style="width: 45%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Han Ying, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 50%; vertical-align: top;"><br>
          </td>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Title:</div>
          </td>
          <td style="width: 45%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Chief Executive Officer</div>
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    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">POWER OF ATTORNEY</div>
    <div>
      <div><br>
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      <div style="text-indent: 36pt; color: #000000;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Han Ying and Ruoyu Chen, or either of them, severally, the individual&#8217;s true and lawful
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        Statement, and any registration statement relating to the offering covered by this Registration Statement and filed pursuant to Rule 462(b) under the Securities Act, and to file the same, with exhibits thereto and other documents in connection
        therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all
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      <div><br>
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      <div style="text-indent: 36pt; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities indicated on March 20, 2025.</div>
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    <div>&#160;<br>
      <div>
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              <td style="width: 27%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="color: #000000;">/s/ Thomas Eastling</div>
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              <td style="width: 19.43%; vertical-align: top; padding-bottom: 2px;"><br>
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              <td colspan="1" style="width: 1.24%; vertical-align: middle; padding-bottom: 2px;"><br>
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              <td colspan="1" style="width: 1.24%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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                <div style="color: #000000;">/s/ David M. Epstein, Ph.D.</div>
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              <td style="width: 19.43%; vertical-align: top; padding-bottom: 2px;"><br>
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              <td colspan="1" style="width: 1.24%; vertical-align: middle; padding-bottom: 2px;"><br>
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              <td colspan="1" style="width: 1.24%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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              <td colspan="1" style="width: 1.24%; vertical-align: middle;"><br>
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                  <div style="color: #000000;">/s/ Rodney L. Nussbaum</div>
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              </td>
              <td style="width: 19.43%; vertical-align: top; padding-bottom: 2px;"><br>
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              <td rowspan="1" style="width: 27%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Renate Parry, Ph.D. </td>
              <td rowspan="1" style="width: 19.43%; vertical-align: top; padding-bottom: 2px;"><br>
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{"company-data": {"conformed-name": "GYRE THERAPEUTICS, INC.", "cik": "0001124105", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "irs-number": "562020050", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-285954", "film-number": "25756371"}, "business-address": {"street1": "12770 HIGH BLUFF DRIVE, SUITE 150", "city": "SAN DIEGO", "state": "CA", "zip": "92130", "phone": "(619) 949-3681"}, "mail-address": {"street1": "12770 HIGH BLUFF DRIVE, SUITE 150", "city": "SAN DIEGO", "state": "CA", "zip": "92130"}, "former-company": [{"former-conformed-name": "CATALYST BIOSCIENCES, INC.", "date-changed": "20150820"}, {"former-conformed-name": "TARGACEPT INC", "date-changed": "20000919"}]}
As filed with the Securities and Exchange Commission on March 20, 2025
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C.  20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Gyre Therapeutics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
56-2020050
(State or Other Jurisdiction of
Incorporation or Organization)
(I.R.S. Employer
Identification No.)
Gyre Therapeutics, Inc.
12770 High Bluff Drive, Suite 150
San Diego, California 92130
(Address, including zip code, of registrant's principal executive offices)
Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan
(Full title of the plan)
Han Ying, Ph.D.
Chief Executive Officer
Gyre Therapeutics, Inc.
12770 High Bluff Drive, Suite 150
San Diego, California 92130
(858) 567-7770
(Name, address and telephone number (including area code) of agent for service)
Copy to:
Sean Feller
Gibson, Dunn & Crutcher LLP
2029 Century Park East, Suite 4000
Los Angeles, CA 90067-3026
(310) 552-8500
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated
      filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☒
Non-accelerated filer
☐
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided
              pursuant to Section 7(a)(2)(B) of the Securities Act.  ☐
EXPLANATORY NOTE
This Registration Statement on Form S-8 (this "Registration Statement") is being filed pursuant to General Instruction E to Form S-8 for the purpose of registering an additional 4,315,377
        shares of common stock, par value $0.001 per share, of Gyre Therapeutics, Inc., a Delaware corporation (the "Registrant") under the Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan (the "Plan"), pursuant to the provisions of the Plan providing
        for an automatic increase in the number of shares reserved and available for issuance under the Plan on January 1, 2025. In accordance with General Instruction E to Form S-8, this Registration Statement hereby incorporates by reference the contents
        of the Registrant's Registration Statements on Form S-8 filed by the Company with respect to the Plan on October 31, 2023 (
SEC File No.
        333-275222
) and March 28, 2024 (
SEC File No. 333-278291
), together
        with all exhibits filed therewith or incorporated therein by reference.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 8.
Exhibits.
Exhibit No.
Exhibit Description
4.1
Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the
                Registrant's Quarterly Report on Form 10-Q filed on November 13, 2024).
4.2
Certificate of Designation of Preferences, Rights and Limitations of Series X Convertible Preferred Stock
                (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on December 27, 2022).
4.3
Amendment to Certificate of Designation of Preferences, Rights and Limitations of Series X Convertible
                Preferred Stock (incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K filed on October 30, 2023).
4.4
Certificate of Designation of Preferences, Rights and Limitations of Series Y Preferred Stock (incorporated
                by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on June 20, 2023).
4.5
Certificate of Elimination of Series Y Preferred Stock (incorporated by reference to Exhibit 3.1 to the
                Registrant's Current Report on Form 8-K filed on August 31, 2023).
4.6
Certificate of Designation of Preferences, Rights and Limitations of Series A Convertible Preferred Stock
                (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on April 13, 2017).
4.7
Certificate of Elimination of Series A Preferred Stock (incorporated by reference to Exhibit 3.6(b) to the
                Registrant's Annual Report on Form 10-K filed on March 27, 2024).
4.8
Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Registrant's
                Current Report on Form 8-K filed on October 30, 2023).
5.1*
Opinion of Gibson, Dunn & Crutcher LLP.
23.1*
Consent of Grant Thornton Zhitong Certified Public Accountants LLP.
23.2*
Consent of Gibson, Dunn & Crutcher LLP (included in Exhibit 5.1).
24.1*
Power of Attorney (included on the signature page hereto).
99.1
Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan (incorporated by reference to
                Exhibit 10.2 to the Registrant's Current Report on Form 8-K filed on October 30, 2023).
107.1*
Filing Fee Table.
*Filed herewith.
SIGNA
TURES
Pursuant to the requirements of the Securities Act of 1933, as amended (the "Securities Act"), the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
      filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on March 20, 2025.
Gyre Therapeutics, Inc.
By:
/s/ Han Ying, Ph.D.
Name:
Han Ying, Ph.D.
Title:
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Han Ying and Ruoyu Chen, or either of them, severally, the individual's true and lawful
        attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Registration
        Statement, and any registration statement relating to the offering covered by this Registration Statement and filed pursuant to Rule 462(b) under the Securities Act, and to file the same, with exhibits thereto and other documents in connection
        therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all
        intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents or their substitute or substitutes may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities indicated on March 20, 2025.
Signature
Title
/s/ Han Ying, Ph.D.
Chief Executive Officer and Director
(
Principal Executive Officer
)
Han Ying, Ph.D.
/s/ Ruoyu Chen
Chief Financial Officer
(
Principal Financial and Accounting Officer
)
Ruoyu Chen
/s/ Songjiang Ma
President and Director
Songjiang Ma
/s/ Gordon G. Carmichael, Ph.D.
Director
Gordon G. Carmichael, Ph.D.
/s/ Thomas Eastling
Director
Thomas Eastling
/s/ David M. Epstein, Ph.D.
Director
David M. Epstein, Ph.D.
/s/ Rodney L. Nussbaum
Director
Rodney L. Nussbaum
/s/ Renate Parry, Ph.D.
Director
Renate Parry, Ph.D.
/s/ Ping Zhang
Director
Ping Zhang