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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 10pt; font-weight: bold;">As filed with the Securities and Exchange Commission on February 22, 2019.</div>
    <div style="text-align: right;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Registration No. 333<font style="font-size: 10pt; font-family: 'Times New Roman';">&#8209;</font></font></div>
    <div style="text-align: center;">
      <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"><font style="font-size: 14pt;
        font-family: &quot;Times New Roman&quot;; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</font></div>
    <div style="text-align: center; font-size: 12pt;"><font style="font-family: &quot;Times New Roman&quot;; font-weight: bold;">Washington, DC 20549</font></div>
    <div>
      <hr style="height: 2px; width: 10%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
    <div style="text-align: center; font-size: 18pt;"><font style="font-family: &quot;Times New Roman&quot;; font-weight: bold;">FORM S-8</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">REGISTRATION STATEMENT</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">UNDER</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">THE SECURITIES ACT OF 1933</font></div>
    <div>
      <hr style="height: 2px; width: 10%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
    <div style="text-align: center; font-size: 24pt;"><font style="font-family: &quot;Times New Roman&quot;; font-weight: bold;">Edge Therapeutics, Inc.</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(Exact name of Registrant as specified in its charter)</font></div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="z2509bdcbd2224703a458dbae41d4f032" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 33.01%; vertical-align: bottom; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Delaware</font></div>
          </td>
          <td style="width: 33.98%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">300 Connell Drive, Suite 4000<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>Berkeley Heights, NJ 07922</font></div>
          </td>
          <td style="width: 33%; vertical-align: bottom; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">26-4231384</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(State of Incorporation)</font></div>
          </td>
          <td style="width: 33.98%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(Address of principal executive offices)</font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(Zip Code)</font></div>
          </td>
          <td style="width: 33%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(I.R.S. Employer Identification No.)</font></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Edge Therapeutics, Inc. 2014 Equity Incentive Plan</font></div>
    <div>
      <hr style="height: 2px; width: 10%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(Full Title of the Plan)</font></div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Brian A. Leuthner</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">President and Chief Executive Officer</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Edge Therapeutics, Inc.</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">300 Connell Drive, Suite 4000</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Berkeley Heights, NJ 07922</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(Name and address of agent for service)</font></div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">(800) 208-3343</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(Telephone number, including area code, of agent for service)</font></div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-style: italic;">Copies of all communications to:</font></div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="z96bf6e29aabe4642b62be72a8132f15d" cellpadding="0" cellspacing="0">

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          <td style="width: 50.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">W. Bradford Middlekauff, Esq.</font></div>
          </td>
          <td style="width: 49.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">David S. Rosenthal, Esq.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 50.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Senior Vice President, General Counsel and Secretary</font></div>
          </td>
          <td style="width: 49.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Dechert LLP</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 50.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Edge Therapeutics, Inc.</font></div>
          </td>
          <td style="width: 49.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">1095 Avenue of the Americas</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 50.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">300 Connell Drive, Suite 4000</font></div>
          </td>
          <td style="width: 49.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">New York, NY 10036</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 50.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Berkeley Heights, NJ 07922</font></div>
          </td>
          <td style="width: 49.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(212) 698-3500</font></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See
        the definitions of <font style="font-size: 10pt; font-family: 'Times New Roman';">&#8220;</font>large accelerated filer,<font style="font-size: 10pt; font-family: 'Times New Roman';">&#8221;</font>&#160;<font style="font-size: 10pt; font-family: 'Times New
          Roman';">&#8220;</font>accelerated filer,<font style="font-size: 10pt; font-family: 'Times New Roman';">&#8221;</font>&#160;<font style="font-size: 10pt; font-family: 'Times New Roman';">&#8220;</font>smaller reporting company<font style="font-size: 10pt; font-family:
          'Times New Roman';">&#8221;</font> and <font style="font-size: 10pt; font-family: 'Times New Roman';">&#8220;</font>emerging growth company<font style="font-size: 10pt; font-family: 'Times New Roman';">&#8221;</font> in Rule 12b-2 of the Securities Exchange Act
        of 1934, as amended. (Check one):</font></div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="z5da500739ade491ca0b9905a7a71bdd5" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 69.97%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Large accelerated filer <font style="font-size: 10pt; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></font></div>
          </td>
          <td style="width: 30.03%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Accelerated filer <font style="font-size: 10pt; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 69.97%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Non-accelerated filer <font style="font-size: 10pt; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font> (Do not check if a smaller reporting
                company)</font></div>
          </td>
          <td style="width: 30.03%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Smaller reporting company <font style="font-size: 10pt; font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</font></font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 69.97%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Emerging growth company <font style="font-size: 10pt; font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</font></font></div>
          </td>
          <td style="width: 30.03%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or
        revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act of 1933, as amended (the <font style="font-size: 10pt; font-family: 'Times New Roman';">&#8220;</font><font style="font-size: 10pt; font-family: 'Times
          New Roman';"><u>Securities Act</u></font><font style="font-size: 10pt; font-family: 'Times New Roman';">&#8221;</font>). <font style="font-size: 10pt; font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</font></font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">CALCULATION OF REGISTRATION FEE</font></div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;"> </font><br>
    </div>
    <table id="z6c23eff29bfe4f21b43c8e27ca87f0f9" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" cellpadding="0" cellspacing="0">

        <tr>
          <td style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Title of securities<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>to be registered</font></div>
          </td>
          <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" nowrap="nowrap" valign="bottom">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Amount to be<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>registered(1)</font></div>
          </td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; padding-bottom: 2px;" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" nowrap="nowrap" valign="bottom">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';"> </font> </div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Proposed<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>maximum<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>offering price per<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>share</font></div>
          </td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; padding-bottom: 2px;" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" nowrap="nowrap" valign="bottom">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';"> </font> </div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Proposed<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>maximum<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>aggregate offering<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>price</font></div>
          </td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; padding-bottom: 2px;" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px;" valign="bottom">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" nowrap="nowrap" valign="bottom">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';"> </font> </div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Amount of<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>registration<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>fee</font></div>
          </td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; padding-bottom: 2px;" nowrap="nowrap" valign="bottom">&#160;</td>
        </tr>
        <tr>
          <td style="vertical-align: top; width: 52%; background-color: #CCEEFF;" valign="bottom">
            <div style="text-align: left; text-indent: -9pt; margin-left: 9pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Common Stock of Edge Therapeutics, Inc., (the <font style="font-size: 10pt; font-family: 'Times New Roman';">&#8220;</font><font style="font-size: 10pt; font-family: 'Times New Roman';">Registrant</font><font style="font-size: 10pt; font-family: 'Times New Roman';">&#8221;</font>) par value $0.00033 per share (<font style="font-size: 10pt; font-family: 'Times New
                  Roman';">&#8220;</font><font style="font-size: 10pt; font-family: 'Times New Roman';">Common Stock</font><font style="font-size: 10pt; font-family: 'Times New Roman';">&#8221;</font>)</font></div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">&#160;</td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom">
            <div><font style="font-size: 10pt; font-family: 'Times New Roman';">1,258,000(2</font></div>
          </td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" nowrap="nowrap" valign="bottom">
            <div><font style="font-size: 10pt; font-family: 'Times New Roman';">)</font></div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">&#160;</td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">
            <div><font style="font-size: 10pt; font-family: 'Times New Roman';">$</font></div>
          </td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom">
            <div><font style="font-size: 10pt; font-family: 'Times New Roman';">0.38</font></div>
          </td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" nowrap="nowrap" valign="bottom">
            <div><font style="font-size: 10pt; font-family: 'Times New Roman';">(3)</font></div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">&#160;</td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">
            <div><font style="font-size: 10pt; font-family: 'Times New Roman';">$</font></div>
          </td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom">
            <div><font style="font-size: 10pt; font-family: 'Times New Roman';">478,040</font></div>
          </td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" nowrap="nowrap" valign="bottom">
            <div><font style="font-size: 10pt; font-family: 'Times New Roman';">(3)</font></div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">&#160;</td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" valign="bottom">$<br>
          </td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" valign="bottom">
            <div><font style="font-size: 10pt; font-family: 'Times New Roman';"></font></div>
            <div><font style="font-size: 10pt; font-family: 'Times New Roman';">57.94</font></div>
          </td>
          <td colspan="1" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" nowrap="nowrap" valign="bottom">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="zdf63e4adc26444fcbe9934550b745d58" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 7.16%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(1)</font></div>
          </td>
          <td style="width: 92.84%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Pursuant to Rules 416(a) and 416(c) of the Securities Act, this registration statement (this <font style="font-size: 10pt; font-family: 'Times New
                  Roman';">&#8220;</font><u><font style="font-size: 10pt; font-family: 'Times New Roman';">Registration Statement</font></u><font style="font-size: 10pt; font-family: 'Times New Roman';">&#8221;</font>) shall also cover any additional shares of Common
                Stock which become issuable under the 2014 Plan (as defined below) by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an increase in the
                number of the outstanding shares of the Registrant<font style="font-size: 10pt; font-family: 'Times New Roman';">&#8217;</font>s Common Stock.</font></div>
          </td>
        </tr>

    </table>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';"> </font><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="za8ac733146b14c9fab97eac4ceb002a5" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 7.16%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(2)</font></div>
          </td>
          <td style="width: 92.84%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Represents an automatic increase to the number of shares available for issuance under the Edge Therapeutics, Inc. 2014 Equity Incentive Plan (the <font style="font-size: 10pt; font-family: 'Times New Roman';">&#8220;</font><u><font style="font-size: 10pt; font-family: 'Times New Roman';">2014 Plan</font></u><font style="font-size: 10pt; font-family: 'Times New Roman';">&#8221;</font>) effective
                January 1, 2019. Shares available for issuance under the 2014 Plan were previously registered on registration statements on Form S-8 filed with the Securities and Exchange Commission (the <font style="font-size: 10pt; font-family: 'Times
                  New Roman';">&#8220;</font><u><font style="font-size: 10pt; font-family: 'Times New Roman';">Commission</font></u><font style="font-size: 10pt; font-family: 'Times New Roman';">&#8221;</font>) on October 21, 2015 (Registration No. 333-207545), March
                9, 2016 (Registration No. 333-210041), March 3, 2017 (Registration No. 333-216430) and March 3, 2018 (Registration No. 333-223389).</font></div>
          </td>
        </tr>

    </table>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';"> </font><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="ze9a5cc8f7f894da08f1914b03f49d169" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 7.16%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(3)</font></div>
          </td>
          <td style="width: 92.84%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Estimated pursuant to Rules 457(c) and 457(h) of the Securities Act, solely for the purpose of calculating the registration fee, based upon the
                average of the reported high and low sales prices for a share of the Registrant<font style="font-size: 10pt; font-family: 'Times New Roman';">&#8217;</font>s Common Stock, as reported on the NASDAQ Global Select Market on February 19, 2019.</font></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>
      <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after:always;" id="DSPFPageBreak">
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    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E</font></div>
    <div><br>
    </div>
    <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Pursuant to General Instruction E of Form S-8, the Registrant is filing this Registration Statement with the Commission to register
        1,258,000 additional shares of Common Stock under its 2014 Plan, pursuant to the provisions of the 2014 Plan providing for an automatic increase in the number of shares reserved for issuance under such plan. This Registration Statement hereby
        incorporates by reference the contents of the Registrant's registration statements on Form S-8 filed with the Commission on October 21, 2015 (Registration No. 333-207545), March 9, 2016 (Registration No. 333-210041), March 3, 2017 (Registration No.
        333-216430) and March 3, 2018 (Registration No. 333-223389). The additional shares are of the same class as other securities relating to the 2014 Plan for which the Registrant<font style="font-size: 10pt; font-family: 'Times New Roman';">&#8217;</font>s
        registration statements on October 21, 2015 (Registration No. 333-207545), March 9, 2016 (Registration No. 333-210041), March 3, 2017 (Registration No. 333-216430) and March 3, 2018 (Registration No. 333-223389) are effective.</font></div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Part II</font></div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</font></div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="zf0f1b89dd2d944b792448740c5775354" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 14.3%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Item 3.</font></div>
          </td>
          <td style="width: 85.7%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Incorporation of Documents by Reference.</font></div>
          </td>
        </tr>

    </table>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
      <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">The following documents, as originally filed with the Commission by the Registrant, are incorporated herein by reference:</font></div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(a)&#160; the Registrant&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed with the Commission on February 21,
          2019 pursuant to Section 13(a) of the Securities Exchange Act of 1934, as amended (the &#8220;<font style="font-size: 10pt; font-family: 'Times New Roman';"><u>Exchange Act</u></font>&#8221;), which contain the Registrant&#8217;s audited financial statements for
          the latest fiscal year for which such statements have been filed;</font></div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(b)&#160;&#160; the description of the Registrant&#8217;s Common Stock, contained in its registration statement on Form 8-A, which was filed with the
          Commission on September 25, 2015; and</font></div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">(c) all reports and other documents hereafter filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d)
          of the Exchange Act, but prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, will be deemed to be
          incorporated by reference in this Registration Statement (other than current reports or portions thereof furnished under Item 2.02 or Item 7.01 of Form 8-K).</font></div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Each document incorporated by reference into this Registration Statement shall be deemed to be a part of this Registration Statement from
          the date of the filing of such document with the Commission, until the information contained in such document is superseded or updated by any subsequently filed document which is incorporated by reference into this Registration Statement.</font></div>
      <div><br>
      </div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
    </div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="z1962449ea5b44adda2c68136b52e6b54" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 14.31%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Item 8.</font></div>
          </td>
          <td style="width: 85.69%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">Exhibits.</font></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">See the Exhibit Index on the page immediately preceding the exhibits for a list of exhibits filed as part of this registration statement
          on Form S-8, which Exhibit Index is incorporated herein by reference.</font></div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman';"><u>Exhibit Index</u></font></font></div>
      <div><br>
      </div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="zc13625580bf54d93aa2111c973aac848" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 8%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Exhibit<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>Number</font></div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
            <div>&#160;</div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Description</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001328/s000911x12_ex3-1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman';">4.1</font></a></div>
            </div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Eighth Amended and Restated Certificate of Incorporation of Edge Therapeutics, Inc. (filed as Exhibit 3.1 to the Registrant&#8217;s Current Report on Form
                  8-K filed with the Commission on October 6, 2015, and incorporated by reference herein).</font></div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001328/s000911x12_ex3-2.htm"><font style="font-size: 10pt; font-family: 'Times New Roman';">4.2</font></a></div>
            </div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Second Amended and Restated Bylaws of Edge Therapeutics, Inc. (filed as Exhibit 3.2 to the Registrant&#8217;s Current Report on Form 8-K filed with the
                  Commission on October 6, 2015, and incorporated by reference herein).</font></div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001209/s000911x5_ex4-1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman';">4.3</font></a></div>
            </div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Form of Certificate of Common Stock (filed as Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form S-1 filed with the Commission on
                  September 21, 2015, and incorporated by reference herein).</font></div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001209/s000911x5_ex10-4.htm"><font style="font-size: 10pt; font-family: 'Times New Roman';">4.4</font></a></div>
            </div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Edge Therapeutics, Inc. 2014 Equity Incentive Plan (filed as Exhibit 10.4 to the Registrant&#8217;s Registration Statement on Form S-1 filed with the
                  Commission on September 21, 2015, and incorporated by reference herein).</font></div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036117010287/ex10_17.htm"><font style="font-size: 10pt; font-family: 'Times New Roman';">4.5</font></a></div>
            </div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Form of Edge Therapeutics, Inc. Executive Stock Option Agreement (filed as Exhibit 10.17 to the Registrant&#8217;s Annual Report on Form 10-K filed with
                  the Commission on March 2, 2017, and incorporated by reference herein).</font></div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036117010287/ex10_18.htm"><font style="font-size: 10pt; font-family: 'Times New Roman';">4.6</font></a></div>
            </div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Form of Edge Therapeutics, Inc. Employee Stock Option Agreement (filed as Exhibit 10.18 to the Registrant&#8217;s Annual Report on Form 10-K filed with
                  the Commission on March 2, 2017, and incorporated by reference herein).</font></div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><a href="s002686x1_ex5-1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman';">5.1</font></a></div>
            </div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Opinion of Dechert LLP (counsel to the Registrant) as to the legality of the securities being registered.</font></div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><a href="s002686x1_ex23-1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman';">23.1</font></a></div>
            </div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Consent of KPMG LLP.</font></div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><a href="s002686x1_ex5-1.htm"><font style="font-size: 10pt; font-family: 'Times New Roman';">23.2</font></a></div>
            </div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Consent of Dechert LLP (included in Exhibit 5.1).</font></div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><a href="#tSIG"><font style="font-size: 10pt; font-family: 'Times New Roman';">24.1</font></a></div>
            </div>
          </td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="background-color: #CCEEFF;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Power of Attorney (contained on the signature page hereto).</font></div>
            </div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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        <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman';"><u><a name="tSIG"><!--Anchor--></a>SIGNATURES</u></font></font></div>
    <div><br>
    </div>
    <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-style: italic;">The Registrant. </font>Pursuant to the requirements of
        the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
        thereunto duly authorized, in the City of Berkeley Heights, State of New Jersey, on this 22<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup> day of February, 2019.</font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';"> </font><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="z0db7dad2955149efb4786762b984c7e4" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 49.35%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td colspan="2" style="width: 50.65%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">EDGE THERAPEUTICS, INC.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.35%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td colspan="2" style="width: 50.65%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 49.35%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 4.08%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">By:</font></div>
          </td>
          <td style="width: 46.57%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">/s/ Brian A. Leuthner</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.35%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 4.08%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 46.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Brian A. Leuthner</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.35%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 4.08%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 46.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';">President and Chief Executive Officer</font></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman'; font-weight: bold;">POWER OF ATTORNEY</font></div>
    <div><br>
    </div>
    <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">KNOW TO ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Brian A. Leuthner, Andrew
        Saik and W. Bradford Middlekauff, and each or any one of them, as such person<font style="font-size: 10pt; font-family: 'Times New Roman';">&#8217;</font>s true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution,
        for such person and in such person<font style="font-size: 10pt; font-family: 'Times New Roman';">&#8217;</font>s name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration
        Statement and to file the same, with all exhibits thereto, with the Commission, granting unto such attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary in
        connection with such matters and hereby ratifying and confirming all that each such attorney-in-fact, or his agent or substitutes, may do or cause to be done by virtue hereof.</font></div>
    <div><br>
    </div>
    <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities
        and on the date indicated.</font></div>
    <div><br>
    </div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman';"> </font><br>
    </div>
    <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="z82bbfe6152874e299b27c856f3996366" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 33%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Signature</font></div>
          </td>
          <td style="width: 34.01%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Title</font></div>
          </td>
          <td style="width: 32.98%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Date</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 34.01%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 32.98%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: bottom; background-color: rgb(255, 255, 255); text-align: center; border-bottom: 2px solid rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">/s/ Brian A. Leuthner</font></font></td>
          <td colspan="1" rowspan="2" style="width: 34.01%; vertical-align: middle; background-color: rgb(255, 255, 255); text-align: center;">
            <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">President and Chief Executive<font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><br>
                </font>Officer and Director<font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><br>
                </font>(Principal Executive Officer)</font></div>
          </td>
          <td colspan="1" rowspan="2" style="width: 32.98%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px; text-align: center;">
            <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">February 22, 2019</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Brian A. Leuthner</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 34.01%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 32.98%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: bottom; background-color: rgb(255, 255, 255); text-align: center; border-bottom: 2px solid rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">/s/ Andrew Saik</font></font></td>
          <td colspan="1" rowspan="2" style="width: 34.01%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Chief Financial Officer<font style="font-size: 10pt; font-family: 'Times New Roman';"><br>
                </font>(Principal Financial Officer)</font></div>
          </td>
          <td colspan="1" rowspan="2" style="width: 32.98%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">February 22, 2019</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Andrew Saik</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 34.01%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 32.98%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: bottom; background-color: rgb(255, 255, 255); text-align: center; border-bottom: 2px solid rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size:
                10pt; font-family: &quot;Times New Roman&quot;;">/s/ Sol Barer</font></font></td>
          <td colspan="1" rowspan="2" style="width: 34.01%; vertical-align: middle; background-color: rgb(255, 255, 255); text-align: center;">
            <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">Chairman, Board of Directors</font></div>
          </td>
          <td colspan="1" rowspan="2" style="width: 32.98%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">February 22, 2019</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Sol Barer</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 34.01%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 32.98%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: bottom; background-color: rgb(255, 255, 255); text-align: center; border-bottom: 2px solid rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">/s/ Isaac Blech</font></font></td>
          <td colspan="1" rowspan="2" style="width: 34.01%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Vice Chairman, Board of Directors</font></div>
          </td>
          <td colspan="1" rowspan="2" style="width: 32.98%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">February 22, 2019</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Isaac Blech</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 34.01%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 32.98%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: bottom; background-color: rgb(255, 255, 255); text-align: center; border-bottom: 2px solid rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">/s/ Rosemary A. Crane</font></font></td>
          <td colspan="1" rowspan="2" style="width: 34.01%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Director</font></div>
          </td>
          <td colspan="1" rowspan="2" style="width: 32.98%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">February 22, 2019</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Rosemary A. Crane</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 34.01%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 32.98%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: bottom; background-color: rgb(255, 255, 255); text-align: center; border-bottom: 2px solid rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">/s/ James Loughlin</font></font></td>
          <td colspan="1" rowspan="2" style="width: 34.01%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Director</font></div>
          </td>
          <td colspan="1" rowspan="2" style="width: 32.98%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">February 22, 2019</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">James Loughlin</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 34.01%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 32.98%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: bottom; background-color: rgb(255, 255, 255); text-align: center; border-bottom: 2px solid rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">/s/ R. Loch Macdonald</font></font></td>
          <td colspan="1" rowspan="2" style="width: 34.01%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Director</font></div>
          </td>
          <td colspan="1" rowspan="2" style="width: 32.98%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">February 22, 2019</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">R. Loch Macdonald</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 34.01%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 32.98%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: bottom; background-color: rgb(255, 255, 255); text-align: center; border-bottom: 2px solid rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">/s/ Liam Ratcliffe</font></font></td>
          <td colspan="1" rowspan="2" style="width: 34.01%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Director</font></div>
          </td>
          <td colspan="1" rowspan="2" style="width: 32.98%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">February 22, 2019</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Liam Ratcliffe</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 34.01%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 32.98%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: bottom; background-color: rgb(255, 255, 255); text-align: center; border-bottom: 2px solid rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">/s/ Robert Spiegel</font></font></td>
          <td colspan="1" rowspan="2" style="width: 34.01%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Director</font></div>
          </td>
          <td colspan="1" rowspan="2" style="width: 32.98%; vertical-align: middle; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">February 22, 2019</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman';">Robert Spiegel</font></div>
          </td>
        </tr>

    </table>
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    </div>
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[{"type": "S-8", "sequence": "1", "filename": "s002686x1_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 68338}]
{"company-data": {"conformed-name": "Edge Therapeutics, Inc.", "cik": "0001472091", "assigned-sic": "2834", "irs-number": "264231384", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-229817", "film-number": "19626746"}, "business-address": {"street1": "300 CONNELL DRIVE", "street2": "SUITE 4000", "city": "BERKELEY HEIGHTS", "state": "NJ", "zip": "07922", "phone": "800-208-3343"}, "mail-address": {"street1": "300 CONNELL DRIVE", "street2": "SUITE 4000", "city": "BERKELEY HEIGHTS", "state": "NJ", "zip": "07922"}}
As filed with the Securities and Exchange Commission on February 22, 2019.
Registration No. 333
‑
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Edge Therapeutics, Inc.
(Exact name of Registrant as specified in its charter)
Delaware
300 Connell Drive, Suite 4000
Berkeley Heights, NJ 07922
26-4231384
(State of Incorporation)
(Address of principal executive offices)
(Zip Code)
(I.R.S. Employer Identification No.)
Edge Therapeutics, Inc. 2014 Equity Incentive Plan
(Full Title of the Plan)
Brian A. Leuthner
President and Chief Executive Officer
Edge Therapeutics, Inc.
300 Connell Drive, Suite 4000
Berkeley Heights, NJ 07922
(Name and address of agent for service)
(800) 208-3343
(Telephone number, including area code, of agent for service)
Copies of all communications to:
W. Bradford Middlekauff, Esq.
David S. Rosenthal, Esq.
Senior Vice President, General Counsel and Secretary
Dechert LLP
Edge Therapeutics, Inc.
1095 Avenue of the Americas
300 Connell Drive, Suite 4000
New York, NY 10036
Berkeley Heights, NJ 07922
(212) 698-3500
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See
        the definitions of
"
large accelerated filer,
"
"
accelerated filer,
"
"
smaller reporting company
"
and
"
emerging growth company
"
in Rule 12b-2 of the Securities Exchange Act
        of 1934, as amended. (Check one):
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☐
(Do not check if a smaller reporting
                company)
Smaller reporting company
☒
Emerging growth company
☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or
        revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act of 1933, as amended (the
"
Securities Act
"
).
☒
CALCULATION OF REGISTRATION FEE
Title of securities
to be registered
Amount to be
registered(1)
Proposed
maximum
offering price per
share
Proposed
maximum
aggregate offering
price
Amount of
registration
fee
Common Stock of Edge Therapeutics, Inc., (the
"
Registrant
"
) par value $0.00033 per share (
"
Common Stock
"
)
1,258,000(2
)
$
0.38
(3)
$
478,040
(3)
$
57.94
(1)
Pursuant to Rules 416(a) and 416(c) of the Securities Act, this registration statement (this
"
Registration Statement
"
) shall also cover any additional shares of Common
                Stock which become issuable under the 2014 Plan (as defined below) by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an increase in the
                number of the outstanding shares of the Registrant
'
s Common Stock.
(2)
Represents an automatic increase to the number of shares available for issuance under the Edge Therapeutics, Inc. 2014 Equity Incentive Plan (the
"
2014 Plan
"
) effective
                January 1, 2019. Shares available for issuance under the 2014 Plan were previously registered on registration statements on Form S-8 filed with the Securities and Exchange Commission (the
"
Commission
"
) on October 21, 2015 (Registration No. 333-207545), March
                9, 2016 (Registration No. 333-210041), March 3, 2017 (Registration No. 333-216430) and March 3, 2018 (Registration No. 333-223389).
(3)
Estimated pursuant to Rules 457(c) and 457(h) of the Securities Act, solely for the purpose of calculating the registration fee, based upon the
                average of the reported high and low sales prices for a share of the Registrant
'
s Common Stock, as reported on the NASDAQ Global Select Market on February 19, 2019.
REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E
Pursuant to General Instruction E of Form S-8, the Registrant is filing this Registration Statement with the Commission to register
        1,258,000 additional shares of Common Stock under its 2014 Plan, pursuant to the provisions of the 2014 Plan providing for an automatic increase in the number of shares reserved for issuance under such plan. This Registration Statement hereby
        incorporates by reference the contents of the Registrant's registration statements on Form S-8 filed with the Commission on October 21, 2015 (Registration No. 333-207545), March 9, 2016 (Registration No. 333-210041), March 3, 2017 (Registration No.
        333-216430) and March 3, 2018 (Registration No. 333-223389). The additional shares are of the same class as other securities relating to the 2014 Plan for which the Registrant
'
s
        registration statements on October 21, 2015 (Registration No. 333-207545), March 9, 2016 (Registration No. 333-210041), March 3, 2017 (Registration No. 333-216430) and March 3, 2018 (Registration No. 333-223389) are effective.
Part II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The following documents, as originally filed with the Commission by the Registrant, are incorporated herein by reference:
(a)  the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed with the Commission on February 21,
          2019 pursuant to Section 13(a) of the Securities Exchange Act of 1934, as amended (the "
Exchange Act
"), which contain the Registrant's audited financial statements for
          the latest fiscal year for which such statements have been filed;
(b)   the description of the Registrant's Common Stock, contained in its registration statement on Form 8-A, which was filed with the
          Commission on September 25, 2015; and
(c) all reports and other documents hereafter filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d)
          of the Exchange Act, but prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, will be deemed to be
          incorporated by reference in this Registration Statement (other than current reports or portions thereof furnished under Item 2.02 or Item 7.01 of Form 8-K).
Each document incorporated by reference into this Registration Statement shall be deemed to be a part of this Registration Statement from
          the date of the filing of such document with the Commission, until the information contained in such document is superseded or updated by any subsequently filed document which is incorporated by reference into this Registration Statement.
Item 8.
Exhibits.
See the Exhibit Index on the page immediately preceding the exhibits for a list of exhibits filed as part of this registration statement
          on Form S-8, which Exhibit Index is incorporated herein by reference.
Exhibit Index
Exhibit
Number
Description
4.1
Eighth Amended and Restated Certificate of Incorporation of Edge Therapeutics, Inc. (filed as Exhibit 3.1 to the Registrant's Current Report on Form
                  8-K filed with the Commission on October 6, 2015, and incorporated by reference herein).
4.2
Second Amended and Restated Bylaws of Edge Therapeutics, Inc. (filed as Exhibit 3.2 to the Registrant's Current Report on Form 8-K filed with the
                  Commission on October 6, 2015, and incorporated by reference herein).
4.3
Form of Certificate of Common Stock (filed as Exhibit 4.1 to the Registrant's Registration Statement on Form S-1 filed with the Commission on
                  September 21, 2015, and incorporated by reference herein).
4.4
Edge Therapeutics, Inc. 2014 Equity Incentive Plan (filed as Exhibit 10.4 to the Registrant's Registration Statement on Form S-1 filed with the
                  Commission on September 21, 2015, and incorporated by reference herein).
4.5
Form of Edge Therapeutics, Inc. Executive Stock Option Agreement (filed as Exhibit 10.17 to the Registrant's Annual Report on Form 10-K filed with
                  the Commission on March 2, 2017, and incorporated by reference herein).
4.6
Form of Edge Therapeutics, Inc. Employee Stock Option Agreement (filed as Exhibit 10.18 to the Registrant's Annual Report on Form 10-K filed with
                  the Commission on March 2, 2017, and incorporated by reference herein).
5.1
Opinion of Dechert LLP (counsel to the Registrant) as to the legality of the securities being registered.
23.1
Consent of KPMG LLP.
23.2
Consent of Dechert LLP (included in Exhibit 5.1).
24.1
Power of Attorney (contained on the signature page hereto).
SIGNATURES
The Registrant.
Pursuant to the requirements of
        the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
        thereunto duly authorized, in the City of Berkeley Heights, State of New Jersey, on this 22
nd
day of February, 2019.
EDGE THERAPEUTICS, INC.
By:
/s/ Brian A. Leuthner
Brian A. Leuthner
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW TO ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Brian A. Leuthner, Andrew
        Saik and W. Bradford Middlekauff, and each or any one of them, as such person
'
s true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution,
        for such person and in such person
'
s name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration
        Statement and to file the same, with all exhibits thereto, with the Commission, granting unto such attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary in
        connection with such matters and hereby ratifying and confirming all that each such attorney-in-fact, or his agent or substitutes, may do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities
        and on the date indicated.
Signature
Title
Date
/s/ Brian A. Leuthner
President and Chief Executive
Officer and Director
(Principal Executive Officer)
February 22, 2019
Brian A. Leuthner
/s/ Andrew Saik
Chief Financial Officer
(Principal Financial Officer)
February 22, 2019
Andrew Saik
/s/ Sol Barer
Chairman, Board of Directors
February 22, 2019
Sol Barer
/s/ Isaac Blech
Vice Chairman, Board of Directors
February 22, 2019
Isaac Blech
/s/ Rosemary A. Crane
Director
February 22, 2019
Rosemary A. Crane
/s/ James Loughlin
Director
February 22, 2019
James Loughlin
/s/ R. Loch Macdonald
Director
February 22, 2019
R. Loch Macdonald
/s/ Liam Ratcliffe
Director
February 22, 2019
Liam Ratcliffe
/s/ Robert Spiegel
Director
February 22, 2019
Robert Spiegel