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  <div style="text-align: center; color: #000000; font-weight: bold;">As filed with the Securities and Exchange Commission on April 5, 2023</div>
  <div style="text-align: right; color: #000000; font-weight: bold;">Registration No. 333-</div>
  <div style="color: rgb(0, 0, 0); font-weight: 400;"> <font style="color: rgb(0, 0, 0);"><br>
    </font></div>
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      <div style="text-align: center; font-size: 14pt; font-weight: bold; color: rgb(0, 0, 0);">UNITED STATES</div>
      <div style="text-align: center; font-size: 14pt; font-weight: bold; color: rgb(0, 0, 0);">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; font-size: 12pt; font-weight: bold; color: rgb(0, 0, 0);">Washington, D.C. 20549</div>
      <div style="text-align: center; color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-align: center; font-size: 18pt; font-weight: bold; color: rgb(0, 0, 0);">FORM S-8</div>
      <div style="text-align: center; font-weight: bold; color: rgb(0, 0, 0);">REGISTRATION STATEMENT</div>
      <div style="text-align: center; font-weight: bold; color: rgb(0, 0, 0);">UNDER</div>
      <div style="text-align: center; font-weight: bold; color: rgb(0, 0, 0);">THE SECURITIES ACT OF 1933</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-align: center; font-size: 24pt; font-variant: small-caps; font-weight: bold; color: rgb(0, 0, 0);">Ocuphire Pharma, Inc.</div>
      <div style="text-align: center; color: rgb(0, 0, 0);">(Exact name of registrant as specified in its charter)</div>
      <div style="text-align: center; color: rgb(0, 0, 0);"><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z370e99abf0354d259c11cc61b8c5781a">

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            <td style="width: 49%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Delaware</div>
            </td>
            <td style="width: 2%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 49%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">11-3516358</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">(State or other jurisdiction of incorporation or organization)</div>
            </td>
            <td style="width: 2%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 49%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">(I.R.S. Employer Identification Number.)</div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z9fe66b6cb99d40789f9b84d20e3a9946">

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            <td style="width: 49%; vertical-align: bottom; color: rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">37000 Grand River Avenue, Suite 120</div>
            </td>
            <td style="width: 2%; vertical-align: bottom; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 49%; vertical-align: bottom; color: rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;"><br>
              </div>
            </td>
          </tr>
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            <td rowspan="1" style="width: 49%; vertical-align: top; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">Farmington Hills, MI</td>
            <td rowspan="1" style="width: 2%; vertical-align: top; padding-bottom: 2px; color: rgb(0, 0, 0);"><br>
            </td>
            <td rowspan="1" style="width: 49%; vertical-align: top; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">48335</td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">(Address of principal executive offices)</div>
            </td>
            <td style="width: 2%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 49%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">(Zip code)</div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Ocuphire Pharma, Inc. 2020 Equity Incentive Plan</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
        <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; color: #000000;"> </div>
      <div style="text-align: center; color: #000000;">(Full title of the plan)</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Mina Sooch</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">President and Chief Executive Officer</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Ocuphire Pharma, Inc.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">37000 Grand River Avenue, Suite 120</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Farmington Hills, MI 48335</div>
      <div style="text-align: center; color: #000000; font-weight: bold;"><font style="color: rgb(0, 0, 0);">(248) 681-9815</font>
        <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; color: #000000;"></div>
      <div style="text-align: center; color: #000000;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Copy to:</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Phillip D. Torrence, Esq.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Emily J. Johns, Esq.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Honigman LLP</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">650 Trade Centre Way, Suite 200</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Kalamazoo, Michigan 49002-0402</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(269) 337-7700</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the
        definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
      <div style="text-align: justify; color: rgb(0, 0, 0);"><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zf673b1f095d14448a8863e2ef90dc987">

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            <td style="width: 45%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Large accelerated filer &#9744;</div>
            </td>
            <td style="width: 55%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Accelerated filer &#9744;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 45%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Non-accelerated filer &#9746;</div>
            </td>
            <td style="width: 55%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Smaller reporting company &#9746;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 45%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 55%; vertical-align: top; color: rgb(0, 0, 0);">
              <div>Emerging growth company &#9744;</div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
        provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
      <div style="text-align: justify; color: rgb(0, 0, 0);"> <br>
      </div>
      <div style="text-align: justify;">
        <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><font style="color: rgb(0, 0, 0);"> </font></div>
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      <div style="text-align: center; color: #000000; font-weight: bold;">EXPLANATORY NOTE</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-indent: 36pt; color: #000000;">This Registration Statement on Form S-8 is being filed by Ocuphire Pharma, Inc. (the &#8220;<font style="font-weight: bold; font-style: italic;">Company</font>&#8221; or &#8220;<font style="font-weight: bold; font-style: italic;">Registrant</font>&#8221; for the purpose of registering an additional 1,043,066 shares of Common Stock issuable pursuant to the Ocuphire Pharma, Inc. 2020 Equity Incentive Plan (the &#8220;<font style="font-weight: bold; font-style: italic;">Equity
          Incentive Plan</font>&#8221;).</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-indent: 36pt; color: #000000;">Pursuant to General Instruction E to Form S-8, this Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a
        Registration Statement of the Company on Form S-8 relating to the Equity Incentive Plan is effective, and the Company&#8217;s Registration Statements on Form S-8 previously filed with the Securities and Exchange Commission (the &#8220;<font style="font-weight: bold; font-style: italic;">Commission</font>&#8221;) on November 9, 2020 (File No. 333-249978), March 31, 2021 (File No. 333-254923), and April 5, 2022 (File No. 333-264139) registering shares of Common Stock issuable under the Equity Incentive Plan
        are incorporated by reference in this Registration Statement.</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">PART II</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd37f1e4baa0a49b7a46c8b3778c04961">

          <tr>
            <td style="width: 72pt; vertical-align: top; color: #000000; font-weight: bold;">Item 3.</td>
            <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="font-weight: bold;">Incorporation of Documents By Reference.</div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-indent: 36pt; color: #000000;">The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z03c7371e968a472bb383f7273efc34a9">

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              <td style="width: 18pt; vertical-align: top; color: #000000;">(a)</td>
              <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
                <div>the Registrant&#8217;s Annual Report on Form 10-K fil<font style="color: rgb(0, 0, 0);">ed on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001228627/000114036123014868/brhc10050364_10k.htm">March <u>30, 2023</u></a>;</font></div>
              </td>
            </tr>

        </table>
        <div style="color: rgb(0, 0, 0);"><br>
        </div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb17920be77bf41ad98b1d431d991d38d">

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              <td style="width: 18pt; vertical-align: top; color: #000000;">(b)</td>
              <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
                <div>the Registrant&#8217;s Current Report on Form 8-K filed on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001228627/000114036123002726/brhc10046995_8k.htm">January 25, 2023</a>;</div>
              </td>
            </tr>

        </table>
        <div style="text-indent: -18pt; margin-left: 18pt; color: rgb(0, 0, 0);"><br>
        </div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z5c6fb7f199624912be904709c92e5973">

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              <td style="width: 18pt; vertical-align: top; color: #000000;">(c)</td>
              <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
                <div>the description of the Company&#8217;s Common Stock contained in the Company&#8217;s Form 8-A (File No. 001-34079), as filed with the Commission pursuant to Sections 12(b) and 12(g) of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange
                  Act&#8221;), on <a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036108013486/form8a12b.htm">May 23, 2008</a>.</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-indent: 36pt; color: #000000;">In addition, all documents the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the filing of this Registration Statement and prior to the filing of
        a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities covered hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part hereof
        from the date of filing of such documents. Notwithstanding anything herein, the Registrant is not incorporating by reference any information furnished under Item 2.02 or Item 7.01 of any Current Report on Form 8-K, unless, and to the extent,
        specified in any such Current Report on Form 8-K.</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-indent: 36pt; color: #000000;">Any statement herein or contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to
        the extent that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated by reference herein, modifies or supersedes such prior statement. Any such statement so modified or superseded shall
        not be deemed, except as so modified or superseded, to constitute part of this Registration Statement.</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
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          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
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            <td style="width: 72pt; vertical-align: top; color: #000000; font-weight: bold;">Item 8.</td>
            <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="font-weight: bold;">Exhibits.</div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">INDEX TO EXHIBITS</div>
      <div style="text-align: center; color: #000000; font-weight: bold;"> <font style="color: rgb(0, 0, 0);"><br>
        </font></div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zc50792de3c4241a89afe06ba05981803">

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            <td style="width: 7.61%; vertical-align: top; border-bottom: #000000 2px solid;">
              <div style="color: #000000; font-weight: bold;">Exhibit</div>
              <div style="color: #000000; font-weight: bold;">Number</div>
            </td>
            <td style="width: 1%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Description</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000089383805000094/corpdefm14a.txt">4.1</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Amended and Restated Certificate of Incorporation (incorporated by reference to Appendix G to the Company&#8217;s Definitive Proxy Statement on Schedule 14A filed on April 29, 2005)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036117018620/ex3_1.htm">4.2</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current Report on Form 8-K, filed on May 5, 2017)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036118037339/ex3_1.htm">4.3</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current Report on Form 8-K, filed on August 30, 2018)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036119006977/ex3_1.htm">4.4</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current Report on Form 8-K, filed on April 12, 2019).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036120024749/brhc10016678_ex3-1.htm">4.5</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current Report on Form 8-K, filed on November 6, 2020)</div>
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          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036120024749/brhc10016678_ex3-2.htm">4.6</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.2 to the Company&#8217;s Current Report on Form 8-K, filed on November 6, 2020)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036120024749/brhc10016678_ex3-3.htm">4.7</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Company&#8217;s Current Report on Form 8-K, filed on November 6, 2020)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036122022593/brhc10038658_ex3-1.htm">4.8</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>First Amendment to Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current Report on Form 8-K, filed on June 10, 2022)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036122023457/brhc10038830_ex3-1.htm">4.9</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Second Amendment to Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current Report on Form 8-K, filed on June 17, 2022)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036120021938/nt10013045x9_s4a.htm">4.10</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Ocuphire Pharma, Inc. 2020 Equity Incentive Plan (incorporated by reference to Annex D to the Company&#8217;s Registration Statement on Form S-4, filed on September 30, 2020)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="brhc10050772_ex5-1.htm">5.1</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Opinion of Honigman LLP</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="brhc10050772_ex23-1.htm">23.1</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Consent of Ernst &amp; Young LLP</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="brhc10050772_ex5-1.htm">23.2</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Consent of Honigman LLP (included in Exhibit 5.1)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="#POWEROFATTORNEY">24.1</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Power of Attorney (included after the signature of the Registrant contained on Signature Page of this Registration Statement)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 7.61%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div><a href="brhc10050772_ex107.htm">107</a></div>
            </td>
            <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 91%; vertical-align: top; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">
              <div>Filing Fee Table</div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div style="page-break-after: always;" class="BRPFPageBreak">
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      <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURES</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-indent: 36pt; color: #000000;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly
        caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Farmington Hills, State of Michigan, on April 5, 2023.</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
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          <tr>
            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0);"><br>
            </td>
            <td colspan="3" style="vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: justify; text-indent: -9.5pt; margin-left: 9.5pt;">OCUPHIRE PHARMA, INC.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0);"><br>
            </td>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);"><br>
            </td>
            <td style="width: 5%; vertical-align: top; color: rgb(0, 0, 0);"><br>
            </td>
            <td style="width: 42%; vertical-align: top; color: rgb(0, 0, 0);"><br>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; padding-bottom: 2px; color: rgb(0, 0, 0);"><br>
            </td>
            <td style="width: 3%; vertical-align: top; padding-bottom: 2px; color: rgb(0, 0, 0);">
              <div style="text-indent: -9.5pt; margin-left: 9.5pt;">By:</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: justify; text-indent: -9.5pt; margin-left: 9.5pt;">/s/ Mina Sooch</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0);"><br>
            </td>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);"><br>
            </td>
            <td style="width: 5%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-indent: -9.5pt; margin-left: 9.5pt;">Name:</div>
            </td>
            <td style="width: 42%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: justify; text-indent: -9.5pt; margin-left: 9.5pt;">Mina Sooch</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; color: rgb(0, 0, 0);"><br>
            </td>
            <td style="width: 3%; vertical-align: top; color: rgb(0, 0, 0);"><br>
            </td>
            <td style="width: 5%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-indent: -9.5pt; margin-left: 9.5pt;">Title:</div>
            </td>
            <td style="width: 42%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: justify; text-indent: -9.5pt; margin-left: 9.5pt;">President and Chief Executive Officer</div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;"><a name="POWEROFATTORNEY"></a><a name="POWEROFAT"></a>POWER OF ATTORNEY</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-indent: 36pt; color: #000000;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Mina Sooch, Bernhard Hoffmann and Amy Rabourn as his or her true and lawful
        attorneys-in-fact and agents with full power of substitution, severally, for him in any and all capacities, to sign the Registration Statement on Form S-8 of Ocuphire Pharma, Inc., and any or all amendments (including post-effective amendments
        thereto), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and
        every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or their
        substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <div style="text-indent: 36pt; color: #000000;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.</div>
      <div style="color: rgb(0, 0, 0);"><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z750d7eed51664f12af94012920abca1d">

          <tr>
            <td style="width: 24.24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">SIGNATURE</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">TITLE</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">DATE</div>
            </td>
          </tr>
          <tr>
            <td style="width: 24.24%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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          <tr>
            <td style="width: 24.24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Mina Sooch</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 24.24%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">Mina Sooch</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top;">
              <div style="text-align: center; color: #000000;">President, Chief Executive Officer &amp; Director</div>
              <div style="text-align: center; color: #000000;">(Principal Executive Officer)</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">April 5, 2023</div>
            </td>
          </tr>
          <tr>
            <td style="width: 24.24%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 24.24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Amy Rabourn</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 24.24%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">Amy Rabourn</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top;">
              <div style="text-align: center; color: #000000;">Senior Vice President of Finance</div>
              <div style="text-align: center; color: #000000;">(Principal Financial and Accounting Officer)</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">
                <div>April 5, 2023</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 24.24%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 24.24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Sean Ainsworth</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 24.24%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">Sean Ainsworth</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">Director</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; color: rgb(0, 0, 0);">
              <div style="text-align: center;">
                <div>April 5, 2023</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 24.24%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 20.87%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 24.24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ James S. Manuso</div>
            </td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 53%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
            <td style="width: 1%; vertical-align: top; color: rgb(0, 0, 0);">&#160;</td>
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[{"type": "S-8", "sequence": "1", "filename": "brhc10050772_s8.htm", "description": "S-8", "secsgml_size_bytes": 56756}]
{"company-data": {"conformed-name": "Ocuphire Pharma, Inc.", "cik": "0001228627", "assigned-sic": "2834", "irs-number": "113516358", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-271150", "film-number": "23803392"}, "business-address": {"street1": "37000 GRAND RIVER AVE.", "street2": "SUITE 120", "city": "FARMINGTON HILLS", "state": "MI", "zip": "48335", "phone": "248-681-9815"}, "mail-address": {"street1": "37000 GRAND RIVER AVE.", "street2": "SUITE 120", "city": "FARMINGTON HILLS", "state": "MI", "zip": "48335"}, "former-company": [{"former-conformed-name": "REXAHN PHARMACEUTICALS, INC.", "date-changed": "20050516"}, {"former-conformed-name": "CORPORATE ROAD SHOW DOT COM INC", "date-changed": "20030423"}]}
As filed with the Securities and Exchange Commission on April 5, 2023
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Ocuphire Pharma, Inc.
(Exact name of registrant as specified in its charter)
Delaware
11-3516358
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification Number.)
37000 Grand River Avenue, Suite 120
Farmington Hills, MI
48335
(Address of principal executive offices)
(Zip code)
Ocuphire Pharma, Inc. 2020 Equity Incentive Plan
(Full title of the plan)
Mina Sooch
President and Chief Executive Officer
Ocuphire Pharma, Inc.
37000 Grand River Avenue, Suite 120
Farmington Hills, MI 48335
(248) 681-9815
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copy to:
Phillip D. Torrence, Esq.
Emily J. Johns, Esq.
Honigman LLP
650 Trade Centre Way, Suite 200
Kalamazoo, Michigan 49002-0402
(269) 337-7700
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the
        definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☐
Accelerated filer ☐
Non-accelerated filer ☒
Smaller reporting company ☒
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
        provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY NOTE
This Registration Statement on Form S-8 is being filed by Ocuphire Pharma, Inc. (the "
Company
" or "
Registrant
" for the purpose of registering an additional 1,043,066 shares of Common Stock issuable pursuant to the Ocuphire Pharma, Inc. 2020 Equity Incentive Plan (the "
Equity
          Incentive Plan
").
Pursuant to General Instruction E to Form S-8, this Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a
        Registration Statement of the Company on Form S-8 relating to the Equity Incentive Plan is effective, and the Company's Registration Statements on Form S-8 previously filed with the Securities and Exchange Commission (the "
Commission
") on November 9, 2020 (File No. 333-249978), March 31, 2021 (File No. 333-254923), and April 5, 2022 (File No. 333-264139) registering shares of Common Stock issuable under the Equity Incentive Plan
        are incorporated by reference in this Registration Statement.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents By Reference.
The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:
(a)
the Registrant's Annual Report on Form 10-K fil
ed on
March
30, 2023
;
(b)
the Registrant's Current Report on Form 8-K filed on
January 25, 2023
;
(c)
the description of the Company's Common Stock contained in the Company's Form 8-A (File No. 001-34079), as filed with the Commission pursuant to Sections 12(b) and 12(g) of the Securities Exchange Act of 1934, as amended (the "Exchange
                  Act"), on
May 23, 2008
.
In addition, all documents the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the filing of this Registration Statement and prior to the filing of
        a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities covered hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part hereof
        from the date of filing of such documents. Notwithstanding anything herein, the Registrant is not incorporating by reference any information furnished under Item 2.02 or Item 7.01 of any Current Report on Form 8-K, unless, and to the extent,
        specified in any such Current Report on Form 8-K.
Any statement herein or contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to
        the extent that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated by reference herein, modifies or supersedes such prior statement. Any such statement so modified or superseded shall
        not be deemed, except as so modified or superseded, to constitute part of this Registration Statement.
Item 8.
Exhibits.
INDEX TO EXHIBITS
Exhibit
Number
Description
4.1
Amended and Restated Certificate of Incorporation (incorporated by reference to Appendix G to the Company's Definitive Proxy Statement on Schedule 14A filed on April 29, 2005)
4.2
Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K, filed on May 5, 2017)
4.3
Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K, filed on August 30, 2018)
4.4
Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K, filed on April 12, 2019).
4.5
Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K, filed on November 6, 2020)
4.6
Certificate of Amendment of Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.2 to the Company's Current Report on Form 8-K, filed on November 6, 2020)
4.7
Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Company's Current Report on Form 8-K, filed on November 6, 2020)
4.8
First Amendment to Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K, filed on June 10, 2022)
4.9
Second Amendment to Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K, filed on June 17, 2022)
4.10
Ocuphire Pharma, Inc. 2020 Equity Incentive Plan (incorporated by reference to Annex D to the Company's Registration Statement on Form S-4, filed on September 30, 2020)
5.1
Opinion of Honigman LLP
23.1
Consent of Ernst & Young LLP
23.2
Consent of Honigman LLP (included in Exhibit 5.1)
24.1
Power of Attorney (included after the signature of the Registrant contained on Signature Page of this Registration Statement)
107
Filing Fee Table
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly
        caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Farmington Hills, State of Michigan, on April 5, 2023.
OCUPHIRE PHARMA, INC.
By:
/s/ Mina Sooch
Name:
Mina Sooch
Title:
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Mina Sooch, Bernhard Hoffmann and Amy Rabourn as his or her true and lawful
        attorneys-in-fact and agents with full power of substitution, severally, for him in any and all capacities, to sign the Registration Statement on Form S-8 of Ocuphire Pharma, Inc., and any or all amendments (including post-effective amendments
        thereto), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and
        every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or their
        substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.
SIGNATURE
TITLE
DATE
/s/ Mina Sooch
Mina Sooch
President, Chief Executive Officer & Director
(Principal Executive Officer)
April 5, 2023
/s/ Amy Rabourn
Amy Rabourn
Senior Vice President of Finance
(Principal Financial and Accounting Officer)
April 5, 2023
/s/ Sean Ainsworth
Sean Ainsworth
Director
April 5, 2023
/s/ James S. Manuso
James S. Manuso
Director
April 5, 2023
/s/ Cam Gallagher
Cam Gallagher
Director
April 5, 2023
/s/ Jay Pepose
Jay Pepose
Director
April 5, 2023
/s/ Richard Rodgers
Richard Rodgers
Director
April 5, 2023
/s/ Susan K. Benton
Susan K. Benton
Director
April 5, 2023