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    <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on [&#8226;], 2022</div>
    <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
    <div>&#160;</div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div>&#160;</div>
    <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div>&#160;</div>
    <div style="text-align: center; font-size: 24pt; font-weight: bold;">Lisata Therapeutics, Inc.</div>
    <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="ze59724448d0a49a6b229d0fe34bdabae">

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          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">22-2343568</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or other jurisdiction of<br>
              incorporation or organization)</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer<br>
              Identification Number)</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">110 Allen Road, Second Floor</div>
    <div style="text-align: center; font-weight: bold;">Basking Ridge, NJ 07920</div>
    <div style="text-align: center; font-weight: bold;">(908) 842-0100</div>
    <div style="text-align: center; font-weight: bold;">(Address, including zip code, and telephone number, including area code, of registrant&#8217;s principal executive offices)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Cend 2016 Equity Incentive Plan</div>
    <div style="text-align: center; font-weight: bold;">Lisata Therapeutics, Inc. 2018 Equity Incentive Compensation Plan</div>
    <div style="text-align: center; font-weight: bold;">(Full Title of the Plan)</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">David J. Mazzo, Ph.D.</div>
    <div style="text-align: center; font-weight: bold;">Chief Executive Officer</div>
    <div style="text-align: center; font-weight: bold;">Lisata Therapeutics, Inc.</div>
    <div style="text-align: center; font-weight: bold;">110 Allen Road, Second Floor</div>
    <div style="text-align: center; font-weight: bold;">Basking Ridge, NJ 07920</div>
    <div style="text-align: center; font-weight: bold;">(908) 842-0100</div>
    <div style="text-align: center; font-weight: bold;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
    <div>&#160;</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">Copies to:</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Jeffrey P. Schultz, Esq.</div>
    <div style="text-align: center; font-weight: bold;">Mintz Levin Cohn Ferris Glovsky &amp;</div>
    <div style="text-align: center; font-weight: bold;">Popeo, P.C.</div>
    <div style="text-align: center; font-weight: bold;">Chrysler Center</div>
    <div style="text-align: center; font-weight: bold;">666 Third Avenue</div>
    <div style="text-align: center; font-weight: bold;">New York, New York 10017</div>
    <div style="text-align: center; font-weight: bold;">(212) 935-3000</div>
    <div>&#160;</div>
    <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
      filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div> <br>
    </div>
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          <td style="width: 15%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Large accelerated filer</div>
          </td>
          <td style="width: 57%; vertical-align: bottom;">&#9744;</td>
          <td style="width: 20%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Accelerated filer</div>
          </td>
          <td style="width: 8%; vertical-align: bottom;">&#9744;</td>
        </tr>
        <tr>
          <td style="width: 15%; vertical-align: middle;">&#160;</td>
          <td style="width: 57%; vertical-align: middle;">&#160;</td>
          <td style="width: 20%; vertical-align: middle;">&#160;</td>
          <td style="width: 8%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 15%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
          </td>
          <td style="width: 57%; vertical-align: bottom;">&#9744;</td>
          <td style="width: 20%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Smaller reporting company</div>
          </td>
          <td style="width: 8%; vertical-align: bottom;">&#9746;</td>
        </tr>
        <tr>
          <td style="width: 15%; vertical-align: middle;">&#160;</td>
          <td style="width: 57%; vertical-align: middle;">&#160;</td>
          <td style="width: 20%; vertical-align: middle;">&#160;</td>
          <td style="width: 8%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 15%; vertical-align: bottom;">&#160;</td>
          <td style="width: 57%; vertical-align: bottom;">&#160;</td>
          <td style="width: 20%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Emerging growth company</div>
          </td>
          <td style="width: 8%; vertical-align: bottom;">&#9744;</td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. &#9744;</div>
    <div><br>
    </div>
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    <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
    <div>&#160;</div>
    <div>On September 15, 2022, Lisata Therapeutics, Inc., formerly known as Caladrius Biosciences, Inc. (the &#8220;Registrant,&#8221; &#8220;we,&#8221; &#8220;us&#8221; or &#8220;our&#8221;), completed its business combination with Cend Therapeutics, Inc. (&#8220;Cend&#8221;) in accordance with the terms of the
      Agreement and Plan of Merger and Reorganization, dated as of April 26, 2022, by and among the Registrant, CS Cedar Merger Sub, Inc. (&#8220;Merger Sub&#8221;) and Cend (the &#8220;Merger Agreement&#8221;), pursuant to which Merger Sub merged with and into Cend, with Cend
      surviving as a wholly owned subsidiary of the Registrant (the &#8220;Merger&#8221;). Pursuant to the Merger Agreement, each option to purchase shares of Cend common stock that was outstanding and unexercised immediately prior to the effective time of the Merger
      under the Cend 2016 Equity Incentive Plan (the &#8220;2016 Plan&#8221;), whether or not vested, was converted into and became an option to purchase shares of Registrant&#8217;s common stock, and the Registrant assumed the Plan.</div>
    <div>&#160;</div>
    <div>The Registrant is also filing this Registration Statement on Form S-8 for the purpose of registering an additional 333,333 shares of the Registrant&#8217;s common stock issuable under the Lisata Therapeutics, Inc. (formerly Caladrius Biosciences, Inc.)
      2018 Equity Incentive Compensation Plan (the &#8220;2018 Plan&#8221; and, together with the 2016 Plan, the &#8220;Plans&#8221;), which shares were added in connection with the Merger and approved by the Registrant&#8217;s stockholders at its annual meeting of stockholders held on
      September 13, 2022.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">PART I</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>
    <div>&#160;</div>
    <div>In accordance with the instructional Note to Part I of Form S-8 as promulgated by the Securities and Exchange Commission (the &#8220;Commission&#8221;), the information specified by Part I of Form S-8 has been omitted from this Registration Statement on Form
      S-8 for offers of the Registrant&#8217;s common stock pursuant to the Plans. The documents containing the information specified in Part I will be delivered to the participants in the Plans covered by this Registration Statement as required by Rule
      428(b)(1) under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;).</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">PART II</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div>&#160;</div>
    <div style="font-style: italic;">In this registration statement, Lisata Therapeutics, Inc. is sometimes referred to as &#8220;Registrant,&#8221; &#8220;we,&#8221; &#8220;us&#8221; or &#8220;our.&#8221;</div>
    <div>&#160;</div>
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          <td style="width: 35.5pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 3.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Incorporation of Documents by Reference.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>The following documents filed by the Registrant with the SEC are incorporated herein by reference:</div>
    <div><br>
    </div>
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          <td style="width: 36pt;">&#160;</td>
          <td style="width: 27pt; vertical-align: top; color: rgb(0, 0, 0);">(a)</td>
          <td style="vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">The Registrant&#8217;s Annual Report on Form 10-K for the year ended December 31, 2021 filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/320017/000032001722000016/clbs-20211231.htm">March














                22, 2022</a>, as amended on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/320017/000032001722000025/clbs-20211231.htm">April 21, 2022;</a></div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4191af30a64b48fd9874da218d1d991c">

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          <td style="width: 36pt;">&#160;</td>
          <td style="width: 27pt; vertical-align: top; color: rgb(0, 0, 0);">(b)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">The Registrant&#8217;s Quarterly Report on Form 10-Q for the quarter ended March 31, 2022 filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/320017/000032001722000042/clbs-20220331.htm">May














                5, 2022</a> and the Registrant&#8217;s Quarterly Report on Form 10-Q for the quarter ended June 30, 2022 filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/320017/000032001722000057/clbs-20220630.htm">August 4, 2022</a>;</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z136d181d71904d4e875e2f5e44a99990">

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          <td style="width: 36pt;">&#160;</td>
          <td style="width: 27pt; vertical-align: top; color: rgb(0, 0, 0);">(c)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">The Registrant&#8217;s Current Reports on Form 8-K as filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/320017/000032001722000005/clbs-20220218.htm">February 18, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/320017/000032001722000008/clbs-20220224.htm">February 25, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/320017/000032001722000031/clbs-20220426.htm">April 27, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/320017/000032001722000071/clbs-20220818.htm">August 19, 2022,</a> <a href="https://www.sec.gov/Archives/edgar/data/320017/000032001722000079/clbs-20220913.htm">September 14, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/320017/000114036122033411/brhc10041800_8k.htm">September 15, 2022</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/320017/000032001722000085/clbs-20220922.htm">September 22, 2022</a>
              (except Item 7.01), <a href="https://www.sec.gov/Archives/edgar/data/320017/000032001722000094/clbs-20220929.htm">September 29, 2022</a>, Form 8-K/A on <a href="https://www.sec.gov/Archives/edgar/data/320017/000114036122036093/brhc10042374_8ka.htm">October 4, 2022</a> and Form 8-K/A (No. 2) on <a href="https://www.sec.gov/Archives/edgar/data/320017/000114036122037226/brhc10042873_8ka.htm">October
                14, 2022</a>;<br>
            </div>
          </td>
        </tr>

    </table>
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          <td style="width: 36pt;">&#160;</td>
          <td style="width: 27pt; vertical-align: top; color: rgb(0, 0, 0);">(d)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">The description of the Registrant&#8217;s common stock contained in the Registrant&#8217;s registration statement on Form 8-A (File No. 001-33650), filed by the Registrant with the SEC under Section 12(b) of the Securities
              Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), on <a href="https://www.sec.gov/Archives/edgar/data/320017/000032001713000063/a8-a1.htm">August 2, 2013</a>, including any amendments or reports filed for the purpose of updating such
              description.</div>
          </td>
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    </table>
    <div> <br>
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    <div>All reports and other documents filed by the Registrant after the date hereof pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished
      on such form that relate to such items), prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated
      by reference herein and to be part hereof from the date of filing of such reports and documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for the
      purposes of this registration statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement
      so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement.</div>
    <div>&#160;</div>
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          <td style="width: 35.5pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 4.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Description of Securities.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>Not applicable.</div>
    <div>&#160;</div>
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          <td style="width: 35.5pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 5.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Interests of Named Experts and Counsel.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>The validity of the issuance of the shares of common stock registered under this Registration Statement has been passed upon the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. A member of that firm owns 66 shares of common stock
      of the Registrant.</div>
    <div>&#160;</div>
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          <td style="width: 35.5pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 6.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Indemnification of Directors and Officers.</div>
          </td>
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    </table>
    <div>&#160;</div>
    <div>Subsection (a) of Section 145 of the General Corporation Law of the State of Delaware (&#8220;DGCL&#8221;) empowers a corporation to indemnify any person who was or is a party or who is threatened to be made a party to any threatened, pending or completed
      action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the corporation) by reason of the fact that the person is or was a director, officer, employee or agent of the
      corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys&#8217; fees), judgments,
      fines and amounts paid in settlement actually and reasonably incurred by the person in connection with such action, suit or proceeding if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the
      best interests of the corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe the person&#8217;s conduct was unlawful.</div>
    <div>&#160;</div>
    <div>Subsection (b) of Section 145 empowers a corporation to indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right of the corporation to procure a
      judgment in its favor by reason of the fact that the person acted in any of the capacities set forth above, against expenses (including attorneys&#8217; fees) actually and reasonably incurred by the person in connection with the defense or settlement of
      such action or suit if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the best interests of the corporation, except that no indemnification shall be made in respect of any claim, issue or
      matter as to which such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery or the court in which such action or suit was brought shall determine upon application that, despite the
      adjudication of liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper.</div>
    <div>&#160;</div>
    <div>Section 145 further provides that to the extent a director or officer of a corporation has been successful on the merits or otherwise in the defense of any action, suit or proceeding referred to in subsections (a) and (b) of Section 145, or in
      defense of any claim, issue or matter therein, such person shall be indemnified against expenses (including attorneys&#8217; fees) actually and reasonably incurred by such person in connection therewith; that indemnification provided for by Section 145
      shall not be deemed exclusive of any other rights to which the indemnified party may be entitled; and the indemnification provided for by Section 145 shall, unless otherwise provided when authorized or ratified, continue as to a person who has ceased
      to be a director, officer, employee or agent and shall inure to the benefit of such person&#8217;s heirs, executors and administrators. Section 145 also empowers the corporation to purchase and maintain insurance on behalf of any person who is or was a
      director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise against any
      liability asserted against such person and incurred by such person in any such capacity, or arising out of his status as such, whether or not the corporation would have the power to indemnify such person against such liabilities under Section 145.</div>
    <div>&#160;</div>
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    <div>Section 102(b)(7) of the DGCL provides that a corporation&#8217;s certificate of incorporation may contain a provision eliminating or limiting the personal liability of a director to the corporation or its stockholders for monetary damages for breach of
      fiduciary duty as a director, provided that such provision shall not eliminate or limit the liability of a director (i) for any breach of the director&#8217;s duty of loyalty to the corporation or its stockholders, (ii) for acts or omissions not in good
      faith or which involve intentional misconduct or a knowing violation of law, (iii) under Section 174 of the DGCL or (iv) for any transaction from which the director derived an improper personal benefit.</div>
    <div>&#160;</div>
    <div>The Registrant&#8217;s amended and restated certificate of incorporation provides that the Registrant, to the fullest extent permitted by law, shall indemnify and advance expenses to any person made or threatened to be made a party to an action, suit or
      proceeding, whether criminal, civil, administrative or investigative, by reason of the fact that he or she, or his or her testator or intestate, is or was a director or officer of the Registrant or any predecessor of the Registrant, or serves or
      served at any other enterprise as a director or officer at the request of the Registrant or any predecessor to the Registrant. The Registrant&#8217;s amended and restated bylaws provide that the Registrant shall indemnify and hold harmless, to the fullest
      extent permitted by the DGCL as it presently exists or may hereafter be amended, any director or officer of the Registrant who was or is made or is threatened to be made a party or is otherwise involved in any action, suit or proceeding, whether
      civil, criminal administrative or investigative, by reason of the fact that he or she, or a person for whom he or she is the legal representative, is or was a director or officer of the corporation or is or was serving at the request of the
      Registrant as a director, officer, employee or agent of another corporation or of a partnership, joint venture, trust, enterprise or nonprofit entity, including service with respect to employee benefit plans, against all liability and loss suffered
      and expenses (including attorneys&#8217; fees) reasonably incurred by such person.</div>
    <div>&#160;</div>
    <div>The Registrant entered into indemnification agreements with each of its directors and executive officers, in addition to the indemnification provided for in its amended and restated certificate of incorporation and by-laws and intends to enter
      into indemnification agreements with any new directors and executive officers in the future.</div>
    <div>&#160;</div>
    <div>The Registrant has purchased and intends to maintain insurance on behalf of any person who is or was a director or officer of the Registrant against any loss arising from any claim asserted against him or her and incurred by him or her in any such
      capacity, subject to certain inclusions.</div>
    <div>&#160;</div>
    <div>Pursuant to the terms of the Merger Agreement, from the effective time of the Merger (the &#8220;Effective Time&#8221;) through the sixth anniversary of the date on which the Effective Time occured, the Registrant must indemnify and hold harmless each person
      was at the Effective Time, or had been at any time prior to the date thereof, or who became prior to the Effective Time, a director or officer of the Registrant or Cend, respectively, against all claims, losses, liabilities, damages, judgments, fines
      and reasonable fees, costs and expenses, including attorneys&#8217; fees and disbursements, incurred in connection with any claim, action, suit, proceeding or investigation to the fullest extent permitted under the DGCL. Each such person is also entitled
      to advancement of expenses incurred in the defense of any such claim, action, suit, proceeding or investigation, provided that such person provides an undertaking required by the DGCL, to repay such advances if it is ultimately determined that such
      person is not entitled to indemnification. From and after the Effective Time, the Registrant is required to maintain directors&#8217; and officers&#8217; liability insurance policies, with an effective date as of the closing date of the Merger, on commercially
      available terms and conditions and with coverage limits customary for U.S. public companies similarly situated to the Registrant. In addition, the Registrant was required to purchase, prior to the Effective Time, a six-year prepaid &#8220;tail policy&#8221; for
      the non-cancellable extension of the directors&#8217; and officers&#8217; liability coverage of the Registrant&#8217;s then-existing directors&#8217; and officers&#8217; insurance policies with terms, conditions, retentions and limits of liability that are no less favorable than
      the current directors&#8217; and officers&#8217; liability insurance policies maintained by the Registrant.</div>
    <div>&#160;</div>
    <div>Further, pursuant to the terms of the Merger Agreement, the provisions of the amended and restated certificate of incorporation and by-laws of the Registrant with respect to indemnification, advancement of expenses and exculpation of present and
      former directors and officers of the Registrant shall not be amended, modified or repealed for a period of six years from the Effective Time in a manner that would adversely affect the rights thereunder of individuals who, at or prior to the
      Effective Time, were officers and directors of the Registrant, unless such modification is required by applicable law.</div>
    <div>&#160;</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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        <tr>
          <td style="width: 35.5pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 7.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Exemption from Registration Claimed.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>Not applicable.</div>
    <div>&#160;</div>
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        <tr>
          <td style="width: 35.5pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 8.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibits.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>Reference is made under this Item 8 to the exhibit list below, included in this Registration Statement.</div>
    <br>
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        <tr>
          <td style="width: 8.4%; vertical-align: top;"><br>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td colspan="5" style="vertical-align: bottom; text-align: center; font-weight: bold;">Incorporated by</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibit</div>
          </td>
          <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td colspan="5" rowspan="1" style="vertical-align: bottom; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#160;&#160;&#160;&#160;Reference</td>
          <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; padding-bottom: 2px;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Filed</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); font-weight: bold;">Number</td>
          <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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            <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibit Description</div>
          </td>
          <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Form</div>
          </td>
          <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Date</div>
          </td>
          <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Number</div>
          </td>
          <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Herewith</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8.42%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>4.1</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/320017/000032001716000143/exhibit31arcertofincorpeff.htm">Amended and Restated Certificate of Incorporation, as amended</a></div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>10-Q</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>8/9/2016</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>3.1</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>4.2</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/320017/000032001722000079/a31caladrius-certificate.htm">Certificate of Amendment to Amended and Restated Certificate of Incorporation</a></div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>8-K</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>9/14/2022</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>3.1</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>4.3</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/320017/000114036122033411/brhc10041800_ex3-2.htm">Certificate of Amendment to Amended and Restated Certificate of Incorporation</a></div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>8-K</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>9/15/2022</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>3.2</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>4.4</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/320017/000032001716000143/exhibit32arbylawseff072720.htm">Amended and Restated By-Laws, as amended</a></div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>10-Q</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>8/9/2016</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>3.2</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>4.5</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/320017/000032001717000082/exhibit31092017.htm">Amendments to Amended and Restated By-Laws</a></div>
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          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>8-K</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>9/21/2017</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>3.1</div>
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          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>5.1</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10042829_ex5-1.htm">Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C</a></div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>23.1</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10042829_ex23-1.htm">Consent of Grant Thornton LLP, independent registered public accounting firm</a></div>
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          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>X</div>
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        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">23.2<br>
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          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1"><a href="brhc10042829_ex23-2.htm">Consent of Withum Smith+Brown,
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          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">X <br>
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        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
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          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10042829_ex5-1.htm">Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in Exhibit 5.1)</a></div>
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          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>24.1</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="#PowerofAttorney">Power of Attorney. Reference is made to the signature page to the Registration Statement</a></div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>99.1#</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10042829_ex99-1.htm">Cend 2016 Equity Incentive Plan, including all amendments thereto</a></div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>99.2#</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/320017/000032001721000056/def14a-2021.htm">Caladrius Biosciences, Inc. 2018 Equity Incentive Compensation Plan, as amended, effective June 16, 2021</a></div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>S-8</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>6/30/2021</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">
            <div>4.1</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.4%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">107<br>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 50%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1"><a href="brhc10042829_ex107.htm">Calculation of Filing Fee Table
            </a><br>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 8.42%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; text-align: center; background-color: rgb(204, 238, 255);" rowspan="1">X <br>
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        </tr>

    </table>
    <div> <br>
    </div>
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        <tr>
          <td style="width: 17.5pt; vertical-align: top; color: rgb(0, 0, 0);">#</td>
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            <div style="color: rgb(0, 0, 0);">Indicates management contract or compensatory plan.</div>
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        </tr>

    </table>
    <div><br>
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        <tr>
          <td style="width: 35.5pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 9.</td>
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          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>1. The Registrant hereby undertakes:</div>
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        <tr>
          <td style="width: 18pt;"><br>
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          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(a)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:</div>
          </td>
        </tr>

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        <tr>
          <td style="width: 36pt;"><br>
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          <td style="width: 27pt; vertical-align: top; color: rgb(0, 0, 0);">(i)</td>
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            <div style="color: rgb(0, 0, 0);">To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;</div>
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        <tr>
          <td style="width: 36pt;"><br>
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            <div style="color: rgb(0, 0, 0);">To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate,
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              exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in
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        </tr>

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    <br>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
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        <tr>
          <td style="width: 36pt;"><br>
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          <td style="width: 27pt; vertical-align: top; color: rgb(0, 0, 0);">(iii)</td>
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            <div style="color: rgb(0, 0, 0);">To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;</div>
          </td>
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    </table>
    <div>&#160;</div>
    <div><font style="font-style: italic;">Provided, however</font>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the registration statement is on Form S-8 and the information required to be included in a post-effective amendment by those
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        <tr>
          <td style="width: 18pt;"><br>
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          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(b)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered
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          </td>
        </tr>

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        <tr>
          <td style="width: 18pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(c)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>2. The Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the Registrant&#8217;s annual report pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934 that is
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    <div>3. Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been
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    <div>Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant has duly caused this Registration Statement on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Basking Ridge
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    <div>KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints David J. Mazzo, Ph.D. as his or her true and lawful attorneys-in-fact and agents, each with full power of substitution, for him or
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As filed with the Securities and Exchange Commission on [•], 2022
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Lisata Therapeutics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
22-2343568
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification Number)
110 Allen Road, Second Floor
Basking Ridge, NJ 07920
(908) 842-0100
(Address, including zip code, and telephone number, including area code, of registrant's principal executive offices)
Cend 2016 Equity Incentive Plan
Lisata Therapeutics, Inc. 2018 Equity Incentive Compensation Plan
(Full Title of the Plan)
David J. Mazzo, Ph.D.
Chief Executive Officer
Lisata Therapeutics, Inc.
110 Allen Road, Second Floor
Basking Ridge, NJ 07920
(908) 842-0100
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
Jeffrey P. Schultz, Esq.
Mintz Levin Cohn Ferris Glovsky &
Popeo, P.C.
Chrysler Center
666 Third Avenue
New York, New York 10017
(212) 935-3000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
      filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☐
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. ☐
EXPLANATORY NOTE
On September 15, 2022, Lisata Therapeutics, Inc., formerly known as Caladrius Biosciences, Inc. (the "Registrant," "we," "us" or "our"), completed its business combination with Cend Therapeutics, Inc. ("Cend") in accordance with the terms of the
      Agreement and Plan of Merger and Reorganization, dated as of April 26, 2022, by and among the Registrant, CS Cedar Merger Sub, Inc. ("Merger Sub") and Cend (the "Merger Agreement"), pursuant to which Merger Sub merged with and into Cend, with Cend
      surviving as a wholly owned subsidiary of the Registrant (the "Merger"). Pursuant to the Merger Agreement, each option to purchase shares of Cend common stock that was outstanding and unexercised immediately prior to the effective time of the Merger
      under the Cend 2016 Equity Incentive Plan (the "2016 Plan"), whether or not vested, was converted into and became an option to purchase shares of Registrant's common stock, and the Registrant assumed the Plan.
The Registrant is also filing this Registration Statement on Form S-8 for the purpose of registering an additional 333,333 shares of the Registrant's common stock issuable under the Lisata Therapeutics, Inc. (formerly Caladrius Biosciences, Inc.)
      2018 Equity Incentive Compensation Plan (the "2018 Plan" and, together with the 2016 Plan, the "Plans"), which shares were added in connection with the Merger and approved by the Registrant's stockholders at its annual meeting of stockholders held on
      September 13, 2022.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
In accordance with the instructional Note to Part I of Form S-8 as promulgated by the Securities and Exchange Commission (the "Commission"), the information specified by Part I of Form S-8 has been omitted from this Registration Statement on Form
      S-8 for offers of the Registrant's common stock pursuant to the Plans. The documents containing the information specified in Part I will be delivered to the participants in the Plans covered by this Registration Statement as required by Rule
      428(b)(1) under the Securities Act of 1933, as amended (the "Securities Act").
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
In this registration statement, Lisata Therapeutics, Inc. is sometimes referred to as "Registrant," "we," "us" or "our."
Item 3.
Incorporation of Documents by Reference.
The following documents filed by the Registrant with the SEC are incorporated herein by reference:
(a)
The Registrant's Annual Report on Form 10-K for the year ended December 31, 2021 filed with the SEC on
March

                22, 2022
, as amended on
April 21, 2022;
(b)
The Registrant's Quarterly Report on Form 10-Q for the quarter ended March 31, 2022 filed with the SEC on
May

                5, 2022
and the Registrant's Quarterly Report on Form 10-Q for the quarter ended June 30, 2022 filed with the SEC on
August 4, 2022
;
(c)
The Registrant's Current Reports on Form 8-K as filed with the SEC on
February 18, 2022
,
February 25, 2022
,
April 27, 2022
,
August 19, 2022,
September 14, 2022
,
September 15, 2022
,
September 22, 2022
(except Item 7.01),
September 29, 2022
, Form 8-K/A on
October 4, 2022
and Form 8-K/A (No. 2) on
October
                14, 2022
;
(d)
The description of the Registrant's common stock contained in the Registrant's registration statement on Form 8-A (File No. 001-33650), filed by the Registrant with the SEC under Section 12(b) of the Securities
              Exchange Act of 1934, as amended (the "Exchange Act"), on
August 2, 2013
, including any amendments or reports filed for the purpose of updating such
              description.
All reports and other documents filed by the Registrant after the date hereof pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished
      on such form that relate to such items), prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated
      by reference herein and to be part hereof from the date of filing of such reports and documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for the
      purposes of this registration statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement
      so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement.
Item 4.
Description of Securities.
Not applicable.
Item 5.
Interests of Named Experts and Counsel.
The validity of the issuance of the shares of common stock registered under this Registration Statement has been passed upon the Registrant by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. A member of that firm owns 66 shares of common stock
      of the Registrant.
Item 6.
Indemnification of Directors and Officers.
Subsection (a) of Section 145 of the General Corporation Law of the State of Delaware ("DGCL") empowers a corporation to indemnify any person who was or is a party or who is threatened to be made a party to any threatened, pending or completed
      action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the corporation) by reason of the fact that the person is or was a director, officer, employee or agent of the
      corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys' fees), judgments,
      fines and amounts paid in settlement actually and reasonably incurred by the person in connection with such action, suit or proceeding if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the
      best interests of the corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe the person's conduct was unlawful.
Subsection (b) of Section 145 empowers a corporation to indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right of the corporation to procure a
      judgment in its favor by reason of the fact that the person acted in any of the capacities set forth above, against expenses (including attorneys' fees) actually and reasonably incurred by the person in connection with the defense or settlement of
      such action or suit if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the best interests of the corporation, except that no indemnification shall be made in respect of any claim, issue or
      matter as to which such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery or the court in which such action or suit was brought shall determine upon application that, despite the
      adjudication of liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper.
Section 145 further provides that to the extent a director or officer of a corporation has been successful on the merits or otherwise in the defense of any action, suit or proceeding referred to in subsections (a) and (b) of Section 145, or in
      defense of any claim, issue or matter therein, such person shall be indemnified against expenses (including attorneys' fees) actually and reasonably incurred by such person in connection therewith; that indemnification provided for by Section 145
      shall not be deemed exclusive of any other rights to which the indemnified party may be entitled; and the indemnification provided for by Section 145 shall, unless otherwise provided when authorized or ratified, continue as to a person who has ceased
      to be a director, officer, employee or agent and shall inure to the benefit of such person's heirs, executors and administrators. Section 145 also empowers the corporation to purchase and maintain insurance on behalf of any person who is or was a
      director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise against any
      liability asserted against such person and incurred by such person in any such capacity, or arising out of his status as such, whether or not the corporation would have the power to indemnify such person against such liabilities under Section 145.
Section 102(b)(7) of the DGCL provides that a corporation's certificate of incorporation may contain a provision eliminating or limiting the personal liability of a director to the corporation or its stockholders for monetary damages for breach of
      fiduciary duty as a director, provided that such provision shall not eliminate or limit the liability of a director (i) for any breach of the director's duty of loyalty to the corporation or its stockholders, (ii) for acts or omissions not in good
      faith or which involve intentional misconduct or a knowing violation of law, (iii) under Section 174 of the DGCL or (iv) for any transaction from which the director derived an improper personal benefit.
The Registrant's amended and restated certificate of incorporation provides that the Registrant, to the fullest extent permitted by law, shall indemnify and advance expenses to any person made or threatened to be made a party to an action, suit or
      proceeding, whether criminal, civil, administrative or investigative, by reason of the fact that he or she, or his or her testator or intestate, is or was a director or officer of the Registrant or any predecessor of the Registrant, or serves or
      served at any other enterprise as a director or officer at the request of the Registrant or any predecessor to the Registrant. The Registrant's amended and restated bylaws provide that the Registrant shall indemnify and hold harmless, to the fullest
      extent permitted by the DGCL as it presently exists or may hereafter be amended, any director or officer of the Registrant who was or is made or is threatened to be made a party or is otherwise involved in any action, suit or proceeding, whether
      civil, criminal administrative or investigative, by reason of the fact that he or she, or a person for whom he or she is the legal representative, is or was a director or officer of the corporation or is or was serving at the request of the
      Registrant as a director, officer, employee or agent of another corporation or of a partnership, joint venture, trust, enterprise or nonprofit entity, including service with respect to employee benefit plans, against all liability and loss suffered
      and expenses (including attorneys' fees) reasonably incurred by such person.
The Registrant entered into indemnification agreements with each of its directors and executive officers, in addition to the indemnification provided for in its amended and restated certificate of incorporation and by-laws and intends to enter
      into indemnification agreements with any new directors and executive officers in the future.
The Registrant has purchased and intends to maintain insurance on behalf of any person who is or was a director or officer of the Registrant against any loss arising from any claim asserted against him or her and incurred by him or her in any such
      capacity, subject to certain inclusions.
Pursuant to the terms of the Merger Agreement, from the effective time of the Merger (the "Effective Time") through the sixth anniversary of the date on which the Effective Time occured, the Registrant must indemnify and hold harmless each person
      was at the Effective Time, or had been at any time prior to the date thereof, or who became prior to the Effective Time, a director or officer of the Registrant or Cend, respectively, against all claims, losses, liabilities, damages, judgments, fines
      and reasonable fees, costs and expenses, including attorneys' fees and disbursements, incurred in connection with any claim, action, suit, proceeding or investigation to the fullest extent permitted under the DGCL. Each such person is also entitled
      to advancement of expenses incurred in the defense of any such claim, action, suit, proceeding or investigation, provided that such person provides an undertaking required by the DGCL, to repay such advances if it is ultimately determined that such
      person is not entitled to indemnification. From and after the Effective Time, the Registrant is required to maintain directors' and officers' liability insurance policies, with an effective date as of the closing date of the Merger, on commercially
      available terms and conditions and with coverage limits customary for U.S. public companies similarly situated to the Registrant. In addition, the Registrant was required to purchase, prior to the Effective Time, a six-year prepaid "tail policy" for
      the non-cancellable extension of the directors' and officers' liability coverage of the Registrant's then-existing directors' and officers' insurance policies with terms, conditions, retentions and limits of liability that are no less favorable than
      the current directors' and officers' liability insurance policies maintained by the Registrant.
Further, pursuant to the terms of the Merger Agreement, the provisions of the amended and restated certificate of incorporation and by-laws of the Registrant with respect to indemnification, advancement of expenses and exculpation of present and
      former directors and officers of the Registrant shall not be amended, modified or repealed for a period of six years from the Effective Time in a manner that would adversely affect the rights thereunder of individuals who, at or prior to the
      Effective Time, were officers and directors of the Registrant, unless such modification is required by applicable law.
Item 7.
Exemption from Registration Claimed.
Not applicable.
Item 8.
Exhibits.
Reference is made under this Item 8 to the exhibit list below, included in this Registration Statement.
Incorporated by
Exhibit
Reference
Filed
Number
Exhibit Description
Form
Date
Number
Herewith
4.1
Amended and Restated Certificate of Incorporation, as amended
10-Q
8/9/2016
3.1
4.2
Certificate of Amendment to Amended and Restated Certificate of Incorporation
8-K
9/14/2022
3.1
4.3
Certificate of Amendment to Amended and Restated Certificate of Incorporation
8-K
9/15/2022
3.2
4.4
Amended and Restated By-Laws, as amended
10-Q
8/9/2016
3.2
4.5
Amendments to Amended and Restated By-Laws
8-K
9/21/2017
3.1
5.1
Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C
X
23.1
Consent of Grant Thornton LLP, independent registered public accounting firm
X
23.2
Consent of Withum Smith+Brown,
              PC, independent registered public accounting firm
X
23.3
Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in Exhibit 5.1)
X
24.1
Power of Attorney. Reference is made to the signature page to the Registration Statement
X
99.1#
Cend 2016 Equity Incentive Plan, including all amendments thereto
X
99.2#
Caladrius Biosciences, Inc. 2018 Equity Incentive Compensation Plan, as amended, effective June 16, 2021
S-8
6/30/2021
4.1
107
Calculation of Filing Fee Table
X
#
Indicates management contract or compensatory plan.
Item 9.
Undertakings.
1. The Registrant hereby undertakes:
(a)
To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
(i)
To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;
(ii)
To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate,
              represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not
              exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in
              volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement;
(iii)
To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;
Provided, however
, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the registration statement is on Form S-8 and the information required to be included in a post-effective amendment by those
      paragraphs is contained in reports filed with or furnished to the SEC by the Registrant pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement.
(b)
That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered
              therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(c)
To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
2. The Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934 that is
      incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
3. Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been
      advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such
      liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
      controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether
      such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.
Signatures
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant has duly caused this Registration Statement on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Basking Ridge
      (Bernards Township), State of New Jersey, on the 17th day of October, 2022.
LISATA THERAPEUTICS, INC.
By:
/s/ David J. Mazzo, Ph.D.
David J. Mazzo, Ph.D.
Chief Executive Officer
Power of Attorney
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints David J. Mazzo, Ph.D. as his or her true and lawful attorneys-in-fact and agents, each with full power of substitution, for him or
      her in any and all capacities, to sign any and all amendments to this Registration Statement, including post-effective amendments or any abbreviated registration statement and any amendments thereto filed pursuant to Rule 462(b) increasing the number
      of securities for which registration is sought, and to file the same, with all exhibits thereto and other documents in connection therewith, with the SEC, granting unto said attorneys-in-fact and agents, with full power of each to act alone, full
      power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that
      said attorneys-in-fact and agents, or his, her or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ David J. Mazzo, Ph.D.
Chief Executive Officer and Director
David J. Mazzo, Ph.D.
(Principal Executive Officer, Principal Financial Officer and Principal Accounting Officer)
October 17, 2022
/s/ David Slack, M.B.A.
President, Chief Business Officer and Director
David Slack, M.B.A.
October 17, 2022
/s/ Gregory B. Brown, M.D.
Chairman of the Board of Directors
Gregory B. Brown, M.D.
October 17, 2022
/s/ Mohammad Azab, M.D., M.B.A.
Director
Mohammad Azab, M.D., M.B.A.
October 17, 2022
/s/ Cynthia L. Flowers, M.B.A.
Director
Cynthia L. Flowers, M.B.A.
October 17, 2022
/s/ Heidi Henson
Director
Heidi Henson
October 17, 2022
/s/ Steven M. Klosk, J.D.
Director
Steven M. Klosk J.D.
October 17, 2022
/s/ Erkki Ruoslahti, M.D., Ph.D.
Director
Erkki Ruoslahti, M.D., Ph.D.
October 17, 2022