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      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">As filed with the Securities and Exchange Commission on November 4, 2021</div>
      <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">Registration No. 333-</div>
    </div>
    <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;">
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      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">UNDER</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;">Bionano Genomics, Inc.</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="ze623e28dcfa141448aaf5a1a7d5d1fcc" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
            </td>
            <td style="width: 2%; vertical-align: top;" colspan="1">&#160;</td>
            <td style="width: 48.88%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">26-1756290</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or other jurisdiction of incorporation or organization)</div>
            </td>
            <td style="width: 2%; vertical-align: top;" colspan="1">&#160;</td>
            <td style="width: 48.88%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer Identification No.)</div>
            </td>
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      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="zcafeec33194e4aca99b74284c0442427" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;" colspan="1">&#160;</td>
            <td style="width: 48.88%; vertical-align: bottom;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">92121</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Address of Principal Executive Offices)</div>
            </td>
            <td style="width: 2%; vertical-align: top;" colspan="1">&#160;</td>
            <td style="width: 48.88%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Zip Code)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc. 2020 Inducement Plan</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Full titles of the plan)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">R. Erik Holmlin, Ph.D.</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">President and Chief Executive Officer</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc.</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California 92121</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(858) 888-7600</div>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">Copies to:</div>
      <table cellspacing="0" cellpadding="0" border="0" id="z2842b588f71e47f8bc7d6eddd7def99f" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Thomas A. Coll, Esq.</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Cooley LLP</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">4401 Eastgate Mall</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California 92121</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(858) 550-6000</div>
            </td>
            <td style="width: 2%; vertical-align: top;" colspan="1">&#160;</td>
            <td style="width: 48.88%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">R. Erik Holmlin, Ph.D.</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">President and Chief Executive Officer</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc.</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California 92121</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(858) 888-7600</div>
            </td>
          </tr>

      </table>
      <div style="color: rgb(0, 0, 0);"> <br>
      </div>
      <div style="color: rgb(0, 0, 0);">Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large
        accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
      <table cellspacing="0" cellpadding="0" border="0" id="zf57a2b8128cc48d3b1d0445f9783a48b" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 43.04%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Large accelerated filer</div>
            </td>
            <td style="width: 6.96%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">&#9744;</div>
            </td>
            <td style="width: 43.04%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Accelerated filer</div>
            </td>
            <td style="width: 6.96%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">&#9744;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 43.04%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
            </td>
            <td style="width: 6.96%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">&#9746;</div>
            </td>
            <td style="width: 43.04%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Smaller reporting company</div>
            </td>
            <td style="width: 6.96%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">&#9746;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 43.04%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Emerging growth company</div>
            </td>
            <td style="width: 6.96%; vertical-align: top;">&#9746;
              <div>&#160;</div>
            </td>
            <td style="width: 43.04%; vertical-align: top;">&#160;</td>
            <td style="width: 6.96%; vertical-align: top;">&#160;</td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
        Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
      <div><br>
      </div>
      <div>
        <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after:always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
      <table cellspacing="0" cellpadding="0" border="0" id="z71a9a6f427354632b2f466530c06f37b" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 46.22%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Title of Securities</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">to be Registered</div>
            </td>
            <td style="width: 13.44%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Amount</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">to be</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Registered<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
            </td>
            <td style="width: 13.44%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Proposed</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Maximum</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Offering Price</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Per Share<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
            </td>
            <td style="width: 13.44%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Proposed</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Maximum</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Aggregate</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Offering Price<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
            </td>
            <td style="width: 13.46%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Amount of</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Registration</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"> Fee</div>
            </td>
          </tr>
          <tr>
            <td style="width: 46.22%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">Common Stock, par value $0.0001 per share</div>
            </td>
            <td style="width: 13.44%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0);">1,000,000<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
            </td>
            <td style="width: 13.44%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0);">$5.25</div>
            </td>
            <td style="width: 13.44%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0);">$5,250,000</div>
            </td>
            <td style="width: 13.46%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0);">$486.68</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" id="z08fc5ee0aa1247fbb20b3635e9a3af57" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 3.5%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">(1)</div>
            </td>
            <td style="width: 96.5%; vertical-align: top;" colspan="3">
              <div style="color: rgb(0, 0, 0);">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Securities Act</font>&#8221;), this Registration Statement shall also cover any
                additional shares of Common Stock, par value $0.0001 per share (&#8220;<font style="font-weight: bold; font-style: italic;">Common Stock</font>&#8221;), of Bionano Genomics, Inc. (the &#8220;<font style="font-weight: bold; font-style: italic;">Registrant</font>&#8221;)




                that become issuable under the Registrant&#8217;s 2020 Inducement Plan, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Inducement Plan</font>&#8221;), by reason of any stock dividend, stock split, recapitalization or other
                similar transaction effected without receipt of consideration which results in an increase in the number of outstanding shares of Common Stock.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3.64%; vertical-align: top;" colspan="3">
              <div style="color: rgb(0, 0, 0);">(2)</div>
            </td>
            <td style="width: 96.36%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">This estimate is made pursuant to Rule 457(h)(1) and Rule 457(c) of the Securities Act solely for purposes of calculating the registration fee. The proposed maximum offering price per share and proposed
                maximum aggregate offering price are based upon the average of the high and low sale prices of the Common Stock on November 1, 2021, as reported on the Nasdaq Capital Market.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3.56%; vertical-align: top;" colspan="2">
              <div style="color: rgb(0, 0, 0);">(3)</div>
            </td>
            <td style="width: 96.44%; vertical-align: top;" colspan="2">
              <div style="color: rgb(0, 0, 0);">Represents an increase in the number of shares of Common Stock reserved for issuance under the Inducement Plan pursuant to an amendment to the Inducement Plan approved by the Board of Directors of the
                Registrant on October 6, 2021.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after:always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">INCORPORATION OF DOCUMENTS BY REFERENCE</div>
      <div><br>
      </div>
      <div style="color: rgb(0, 0, 0);">This Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a Registration Statement of the Registrant on Form S-8 relating to the
        same employee benefit plan is effective.</div>
      <div><br>
      </div>
      <div><font style="color: rgb(0, 0, 0);">The Registrant previously registered shares of its Common Stock for issuance under the Inducement Plan under Registration Statements on Form S-8 filed with the Securities and Exchange Commission (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: rgb(0, 0, 0);">Commission</font><font style="color: rgb(0, 0, 0);">&#8221;) on </font><a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036120019327/nt10014149x5_s8.htm"><font style="color: rgb(5, 99, 193);"><u>August 28, 2020 (File No. </u></font><font style="color: rgb(5, 99, 193);"><u>333-248468)</u></font></a><font style="color: rgb(0, 0, 0);">. Pursuant to General Instruction E to Form S-8, this Registration
          Statement hereby incorporates by reference the contents of the Registration Statement referenced above.</font></div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" id="zecfe0788a7174aabaf1f92eb236653bd" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">ITEM 8.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">EXHIBITS.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="za15caea62bb347ad938cbd118f699909" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 8%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibit</div>
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Number</div>
            </td>
            <td style="width: 92%; vertical-align: bottom;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Description</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(5, 99, 193);"><a href="https://www.sec.gov/Archives/edgar/data/1411690/000141169021000004/ex31-arcertificateofincorp.htm"><u>4.1</u><u>(1)</u></a></div>
            </td>
            <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Amended and Restated Certificate of Incorporation of the Registrant, as amended.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(5, 99, 193);"><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518257763/d607608dex32.htm"><u>4.2</u><u>(2)</u></a></div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Amended and Restated Bylaws of the Registrant.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(5, 99, 193);"><a href="https://www.sec.gov/Archives/edgar/data/0001411690/000119312518219135/d782664dex41.htm"><u>4.3</u><u>(3)</u></a></div>
            </td>
            <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Form of Common Stock Certificate of the Registrant.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 238);"><a href="brhc10030312_ex5-1.htm">5.1</a></div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Opinion of Cooley LLP.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 238);"><a href="brhc10030312_ex23-1.htm">23.1</a></div>
            </td>
            <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Consent of BDO USA LLP, Independent Registered Public Accounting Firm.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 238);"><a href="brhc10030312_ex23-2.htm">23.2</a></div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Consent of Deloitte &amp; Touche LLP, Independent Registered Public Accounting Firm.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 238);"><a href="brhc10030312_ex5-1.htm">23.3</a></div>
            </td>
            <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Consent of Cooley LLP. Reference is made to Exhibit 5.1.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 238);"><a href="#POWEROFATTORNEY">24.1</a></div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Power of Attorney. Reference is made to the signature page hereto.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(5, 99, 193);"><a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036121034291/brhc10029776_ex10-1.htm"><u>99.1</u><u>(4)</u></a></div>
            </td>
            <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Bionano Genomics, Inc. 2020 Inducement Plan, as amended.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(5, 99, 193);"><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518219135/d782664dex105.htm"><u>99.2</u><u>(5)</u></a></div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Form of Stock Option Grant Notice and Stock Option Agreement under the Bionano Genomics, Inc. 2020 Inducement Plan.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" id="z79291522f70243e6917c9f2f4cfa848c" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 3.54%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">(1)</div>
            </td>
            <td style="width: 96.46%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Annual Report on Form 10-K, filed with the SEC on March 23, 2021.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3.54%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">(2)</div>
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            <td style="width: 96.46%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Current Report on Form 8-K, filed with the SEC on August 24, 2018.</div>
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          </tr>
          <tr>
            <td style="width: 3.54%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">(3)</div>
            </td>
            <td style="width: 96.46%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Registration Statement on Form S-1 (File No. 333-225970), as amended.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3.54%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">(4)</div>
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            <td style="width: 96.46%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Current Report on Form 8-K, filed with the SEC on October 12, 2021.</div>
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          </tr>
          <tr>
            <td style="width: 3.54%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">(5)</div>
            </td>
            <td style="width: 96.46%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Current Report on Form 8-K, filed with the SEC on August 24, 2020.</div>
            </td>
          </tr>

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      <div>&#160;</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">SIGNATURES</div>
      <div><br>
      </div>
      <div><font style="color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
          duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on November </font>4<font style="color: rgb(0, 0, 0);">, 2021.</font></div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="zc671dd593a7349a5bd3ee2bc484e0935" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 4%; vertical-align: middle;">&#160;</td>
            <td style="width: 35%; vertical-align: bottom;">&#160;</td>
            <td style="width: 61%; vertical-align: top;">&#160;</td>
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          <tr>
            <td style="vertical-align: top;" colspan="2">
              <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0); font-weight: bold;">BIONANO GENOMICS, INC.</div>
            </td>
            <td style="width: 61%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
            <td style="width: 61%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 4%; vertical-align: top;">
              <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0);">By:</div>
            </td>
            <td style="width: 35%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0);">/s/ R. Erik Holmlin, Ph.D.</div>
            </td>
            <td style="width: 61%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 4%; vertical-align: top;">&#160;</td>
            <td style="width: 35%; vertical-align: bottom;">
              <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0);">R. Erik Holmlin, Ph.D.</div>
            </td>
            <td style="width: 61%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 4%; vertical-align: top;">&#160;</td>
            <td style="width: 35%; vertical-align: bottom;">
              <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0); font-style: italic;">President and Chief Executive Officer</div>
            </td>
            <td style="width: 61%; vertical-align: top;">&#160;</td>
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      </table>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
      <div><br>
      </div>
      <div style="color: rgb(0, 0, 0);">KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints R. Erik Holmlin, Ph.D. as his or her true and lawful attorney-in-fact and agent, with the full power of
        substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with exhibits thereto and
        other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and
        about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by
        virtue hereof.</div>
      <div><br>
      </div>
      <div style="color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</div>
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            <td style="width: 20.14%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Signature</div>
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            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;">
              <div>&#8203;</div>
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            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;">
              <div>&#8203;</div>
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            <td style="width: 60.32%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Title</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Date</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ R. Erik Holmlin,Ph.D.</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;" rowspan="2">
              <div>&#8203;</div>
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            <td style="width: 60.32%; vertical-align: top; padding-bottom: 2px;" rowspan="2">
              <div style="text-align: center;">President, Chief Executive Officer and Director</div>
              <div style="text-align: center; font-style: italic;">(Principal Executive Officer)</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center;">November 4, 2021</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">
              <div style="text-align: center;">R. Erik Holmlin, Ph.D.</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.01%; vertical-align: middle;">&#160;</td>
            <td style="width: 1.01%; vertical-align: middle;" colspan="1">&#160;</td>
            <td style="vertical-align: middle; width: 16%;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">&#160;</td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 60.32%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: middle; width: 1.01%;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Christopher Stewart</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;" rowspan="2">
              <div>&#8203;</div>
            </td>
            <td style="width: 60.32%; vertical-align: top; padding-bottom: 2px;" rowspan="2">
              <div style="text-align: center;">Chief Financial Officer</div>
              <div style="text-align: center; font-style: italic;">(Principal Financial and Accounting Officer)</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center;">November 4, 2021</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">
              <div style="text-align: center;">Christopher Stewart</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.01%; vertical-align: middle;">&#160;</td>
            <td style="width: 1.01%; vertical-align: middle;" colspan="1">&#160;</td>
            <td style="vertical-align: middle; width: 16%;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">&#160;</td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 60.32%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: middle; width: 1.01%;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ David L. Barker, Ph.D.</div>
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            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;" rowspan="2">
              <div>&#8203;</div>
            </td>
            <td style="width: 60.32%; vertical-align: top; padding-bottom: 2px;" rowspan="2">
              <div style="text-align: center;">Director</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center;">November 4, 2021</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">
              <div style="text-align: center;">David L. Barker, Ph.D.</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.01%; vertical-align: middle;">&#160;</td>
            <td style="width: 1.01%; vertical-align: middle;" colspan="1">&#160;</td>
            <td style="vertical-align: middle; width: 16%;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">&#160;</td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 60.32%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: middle; width: 1.01%;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Yvonne Linney, Ph.D.</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;" rowspan="2">
              <div>&#8203;</div>
            </td>
            <td style="width: 60.32%; vertical-align: top; padding-bottom: 2px;" rowspan="2">
              <div style="text-align: center;">Director</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center;">November 4, 2021</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">
              <div style="text-align: center;">Yvonne Linney, Ph.D.</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.01%; vertical-align: middle;">&#160;</td>
            <td style="width: 1.01%; vertical-align: middle;" colspan="1">&#160;</td>
            <td style="vertical-align: middle; width: 16%;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">&#160;</td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 60.32%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: middle; width: 1.01%;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Albert A. Luderer, Ph.D.</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;" rowspan="2">
              <div>&#8203;</div>
            </td>
            <td style="width: 60.32%; vertical-align: top; padding-bottom: 2px;" rowspan="2">
              <div style="text-align: center;">Director</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center;">November 4, 2021</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">
              <div style="text-align: center;">Albert A. Luderer, Ph.D.</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.01%; vertical-align: middle;">&#160;</td>
            <td style="width: 1.01%; vertical-align: middle;" colspan="1">&#160;</td>
            <td style="vertical-align: middle; width: 16%;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">&#160;</td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 60.32%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: middle; width: 1.01%;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Hannah Mamuszka</div>
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            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;" rowspan="2">
              <div>&#8203;</div>
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            <td style="width: 60.32%; vertical-align: top; padding-bottom: 2px;" rowspan="2">
              <div style="text-align: center;">Director</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center;">November 4, 2021</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">
              <div style="text-align: center;">Hannah Mamuszka</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.01%; vertical-align: middle;">&#160;</td>
            <td style="width: 1.01%; vertical-align: middle;" colspan="1">&#160;</td>
            <td style="vertical-align: middle; width: 16%;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top;">&#160;</td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle;">
              <div>&#8203;</div>
            </td>
            <td style="width: 60.32%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: middle; width: 1.01%;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20.14%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Christopher Twomey</div>
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            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="width: 1.21%; vertical-align: middle; padding-bottom: 2px;" rowspan="2">
              <div>&#8203;</div>
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            <td style="width: 60.32%; vertical-align: top; padding-bottom: 2px;" rowspan="2">
              <div style="text-align: center;">Director</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;">
              <div>&#8203;</div>
            </td>
            <td style="vertical-align: middle; width: 1.01%; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td style="width: 16%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center;">November 4, 2021</div>
            </td>
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          <tr>
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[{"type": "S-8", "sequence": "1", "filename": "brhc10030312_s8.htm", "description": "S-8", "secsgml_size_bytes": 52906}]
{"company-data": {"conformed-name": "Bionano Genomics, Inc.", "cik": "0001411690", "assigned-sic": "3826", "irs-number": "261756290", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-260762", "film-number": "211380165"}, "business-address": {"street1": "9540 TOWNE CENTRE DRIVE", "street2": "SUITE 100", "city": "SAN DIEGO", "state": "CA", "zip": "92121", "phone": "(858) 888-7600"}, "mail-address": {"street1": "9540 TOWNE CENTRE DRIVE", "street2": "SUITE 100", "city": "SAN DIEGO", "state": "CA", "zip": "92121"}, "former-company": [{"former-conformed-name": "Bionano Genomics, Inc", "date-changed": "20190308"}, {"former-conformed-name": "BioNano Genomics, Inc", "date-changed": "20120703"}, {"former-conformed-name": "BioNanomatrix Inc", "date-changed": "20070906"}]}
As filed with the Securities and Exchange Commission on November 4, 2021
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Bionano Genomics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
26-1756290
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
9540 Towne Centre Drive, Suite 100
San Diego, California
92121
(Address of Principal Executive Offices)
(Zip Code)
Bionano Genomics, Inc. 2020 Inducement Plan
(Full titles of the plan)
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
Bionano Genomics, Inc.
9540 Towne Centre Drive, Suite 100
San Diego, California 92121
(858) 888-7600
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
Thomas A. Coll, Esq.
Cooley LLP
4401 Eastgate Mall
San Diego, California 92121
(858) 550-6000
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
Bionano Genomics, Inc.
9540 Towne Centre Drive, Suite 100
San Diego, California 92121
(858) 888-7600
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large
        accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☒
If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
        Section 7(a)(2)(B) of the Securities Act. ☐
CALCULATION OF REGISTRATION FEE
Title of Securities
to be Registered
Amount
to be
Registered
(1)
Proposed
Maximum
Offering Price
Per Share
(2)
Proposed
Maximum
Aggregate
Offering Price
(2)
Amount of
Registration
Fee
Common Stock, par value $0.0001 per share
1,000,000
(3)
$5.25
$5,250,000
$486.68
(1)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "
Securities Act
"), this Registration Statement shall also cover any
                additional shares of Common Stock, par value $0.0001 per share ("
Common Stock
"), of Bionano Genomics, Inc. (the "
Registrant
")

                that become issuable under the Registrant's 2020 Inducement Plan, as amended (the "
Inducement Plan
"), by reason of any stock dividend, stock split, recapitalization or other
                similar transaction effected without receipt of consideration which results in an increase in the number of outstanding shares of Common Stock.
(2)
This estimate is made pursuant to Rule 457(h)(1) and Rule 457(c) of the Securities Act solely for purposes of calculating the registration fee. The proposed maximum offering price per share and proposed
                maximum aggregate offering price are based upon the average of the high and low sale prices of the Common Stock on November 1, 2021, as reported on the Nasdaq Capital Market.
(3)
Represents an increase in the number of shares of Common Stock reserved for issuance under the Inducement Plan pursuant to an amendment to the Inducement Plan approved by the Board of Directors of the
                Registrant on October 6, 2021.
INCORPORATION OF DOCUMENTS BY REFERENCE
This Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a Registration Statement of the Registrant on Form S-8 relating to the
        same employee benefit plan is effective.
The Registrant previously registered shares of its Common Stock for issuance under the Inducement Plan under Registration Statements on Form S-8 filed with the Securities and Exchange Commission (the "
Commission
") on
August 28, 2020 (File No.
333-248468)
. Pursuant to General Instruction E to Form S-8, this Registration
          Statement hereby incorporates by reference the contents of the Registration Statement referenced above.
ITEM 8.
EXHIBITS.
Exhibit
Number
Description
4.1
(1)
Amended and Restated Certificate of Incorporation of the Registrant, as amended.
4.2
(2)
Amended and Restated Bylaws of the Registrant.
4.3
(3)
Form of Common Stock Certificate of the Registrant.
5.1
Opinion of Cooley LLP.
23.1
Consent of BDO USA LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Deloitte & Touche LLP, Independent Registered Public Accounting Firm.
23.3
Consent of Cooley LLP. Reference is made to Exhibit 5.1.
24.1
Power of Attorney. Reference is made to the signature page hereto.
99.1
(4)
Bionano Genomics, Inc. 2020 Inducement Plan, as amended.
99.2
(5)
Form of Stock Option Grant Notice and Stock Option Agreement under the Bionano Genomics, Inc. 2020 Inducement Plan.
(1)
Incorporated by reference to the Registrant's Annual Report on Form 10-K, filed with the SEC on March 23, 2021.
(2)
Incorporated by reference to the Registrant's Current Report on Form 8-K, filed with the SEC on August 24, 2018.
(3)
Incorporated by reference to the Registrant's Registration Statement on Form S-1 (File No. 333-225970), as amended.
(4)
Incorporated by reference to the Registrant's Current Report on Form 8-K, filed with the SEC on October 12, 2021.
(5)
Incorporated by reference to the Registrant's Current Report on Form 8-K, filed with the SEC on August 24, 2020.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
          duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on November
4
, 2021.
BIONANO GENOMICS, INC.
By:
/s/ R. Erik Holmlin, Ph.D.
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints R. Erik Holmlin, Ph.D. as his or her true and lawful attorney-in-fact and agent, with the full power of
        substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with exhibits thereto and
        other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and
        about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by
        virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
​
​
Title
​
Date
/s/ R. Erik Holmlin,Ph.D.
​
​
President, Chief Executive Officer and Director
(Principal Executive Officer)
​
November 4, 2021
R. Erik Holmlin, Ph.D.
​
​
​
​
/s/ Christopher Stewart
​
​
Chief Financial Officer
(Principal Financial and Accounting Officer)
​
November 4, 2021
Christopher Stewart
​
​
​
​
/s/ David L. Barker, Ph.D.
​
​
Director
​
November 4, 2021
David L. Barker, Ph.D.
​
​
​
​
/s/ Yvonne Linney, Ph.D.
​
​
Director
​
November 4, 2021
Yvonne Linney, Ph.D.
​
​
​
​
/s/ Albert A. Luderer, Ph.D.
​
​
Director
​
November 4, 2021
Albert A. Luderer, Ph.D.
​
​
​
​
/s/ Hannah Mamuszka
​
​
Director
​
November 4, 2021
Hannah Mamuszka
​
​
​
​
/s/ Christopher Twomey
​
​
Director
​
November 4, 2021
Christopher Twomey
​
​
​
​
/s/ Kristiina Vuori, M.D., Ph.D.
​
​
Director
​
November 4, 2021
Kristiina Vuori, M.D., Ph.D.
​