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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">As filed with the Securities and Exchange Commission
on June&nbsp;18, 2025.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Registration No.&nbsp;333-</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Washington, D.C. 20549</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Form&nbsp;S-8</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION STATEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNDER</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>THE SECURITIES ACT OF 1933</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>INCYTE CORPORATION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in its charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; width: 40%"><FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; width: 23%">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; width: 37%"><FONT STYLE="font-size: 10pt"><B>94-3136539</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or other jurisdiction of</FONT></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">incorporation or organization)</FONT></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">Identification No.)</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding-right: 5.4pt; padding-left: 5.4pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>1801 Augustine Cut-Off</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Wilmington, Delaware</B></P></TD>
    <TD STYLE="vertical-align: top; padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>19803</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">(Address of Principal Executive Offices)</FONT></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">(Zip Code)</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>1997 EMPLOYEE STOCK PURCHASE PLAN OF</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INCYTE CORPORATION</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plan)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">HERV&Eacute; HOPPENOT</FONT></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">Copy to:</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">President and Chief Executive Officer</FONT></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">STANTON D. WONG</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">Incyte Corporation</FONT></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">Pillsbury Winthrop Shaw Pittman LLP</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">1801 Augustine Cut-Off</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Wilmington, Delaware</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(302) 498-6700</P></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Four Embarcadero Center, 22nd Floor</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">San Francisco, California 94111</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(415) 983-1000</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address and telephone number,</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">including area code, of agent for service)</P></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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    <TD STYLE="width: 100%"><FONT STYLE="font-size: 10pt">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer,&rdquo; &ldquo;smaller reporting company,&rdquo; and &ldquo;emerging growth company&rdquo; in Rule&nbsp;12b-2 of the Exchange Act.</FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 45%; text-align: center"><FONT STYLE="font-size: 10pt">Large accelerated filer&nbsp;<FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT></TD>
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 49%; text-align: center"><FONT STYLE="font-size: 10pt">Accelerated&nbsp;filer&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Non-accelerated filer&nbsp;<FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 42pt">(Do not check if a smaller reporting
    company)</P></TD>
    <TD>&nbsp;</TD>
    <TD><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Smaller reporting company&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Emerging growth company
<FONT STYLE="font-family: Wingdings">&#168;</FONT></P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section&nbsp;7(a)(2)(B)&nbsp;of the Securities Act. <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART&nbsp;I</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>INFORMATION REQUIRED PURSUANT</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>TO GENERAL INSTRUCTION E TO FORM&nbsp;S-8</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>General Instruction&nbsp;E Information</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This registration statement (the &ldquo;Registration
Statement&rdquo;) is being filed for the purpose of increasing the number of securities of the same class as other securities for which
a Registration Statement of Incyte Corporation (the &ldquo;Registrant&rdquo;) on Form&nbsp;S-8 relating to the same employee benefit plan
is effective.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Registrant&rsquo;s Form&nbsp;S-8 Registration
Statements filed with the Securities and Exchange Commission on <A HREF="https://www.sec.gov/Archives/edgar/data/879169/0000950149-97-001373-index.html" STYLE="-sec-extract: exhibit">July&nbsp;16, 1997 (File No.&nbsp;333-31409)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000095000800000233/0000950008-00-000233-0001.txt" STYLE="-sec-extract: exhibit">October&nbsp;3, 2000 (File No.&nbsp;333-47180)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000101287001501655/ds8.txt" STYLE="-sec-extract: exhibit">August&nbsp;15, 2001 (File No.&nbsp;333-67596)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000101287002002879/ds8.htm" STYLE="-sec-extract: exhibit">June&nbsp;28, 2002 (File No.&nbsp;333-91540)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000119312503038569/ds8.htm" STYLE="-sec-extract: exhibit">August&nbsp;15, 2003
(File No.&nbsp;333-108013)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000110465906037592/a06-12585_1s8.htm" STYLE="-sec-extract: exhibit">May&nbsp;25, 2006 (File No.&nbsp;333-134472)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000110465908040457/a08-16807_1s8.htm" STYLE="-sec-extract: exhibit">June&nbsp;17, 2008 (File No.&nbsp;333-151715)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000110465909038377/a09-15708_2s8.htm" STYLE="-sec-extract: exhibit">June&nbsp;16, 2009 (File No.&nbsp;333-160007)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000110465910033920/a10-11914_2s8.htm" STYLE="-sec-extract: exhibit">June&nbsp;15, 2010 (File No.&nbsp;333-167528)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000110465911034854/a11-14920_2s8.htm" STYLE="-sec-extract: exhibit">June&nbsp;15, 2011 (File No.&nbsp;333-174919)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000110465916128056/a16-13524_1s8.htm" STYLE="-sec-extract: exhibit">June&nbsp;17, 2016 (File No.&nbsp;333-212102)</A>, <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000110465920073153/tm2022470-1_s8.htm" STYLE="-sec-extract: exhibit">June&nbsp;15, 2020 (File No.&nbsp;333-239162)</A>, and <A HREF="https://www.sec.gov/Archives/edgar/data/879169/000110465923077053/tm2319767d1_s8.htm" STYLE="-sec-extract: exhibit">June&nbsp;30, 2023 (333-273056)</A> are hereby incorporated by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Part&nbsp;II</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Information Required in the Registration Statement</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.5in"><B>Item 3.</B></TD><TD><B>Incorporation of Documents by Reference.</B></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following documents previously filed by Registrant
with the Securities and Exchange Commission are hereby incorporated by reference in this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(1)</TD><TD><A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/879169/000162828025004633/incy-20241231.htm" STYLE="-sec-extract: exhibit">Registrant&rsquo;s Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 2024;</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(2)</TD><TD><A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/879169/000087916925000056/incy-20250331.htm" STYLE="-sec-extract: exhibit">Registrant&rsquo;s Quarterly Report on Form&nbsp;10-Q for the quarter ended March&nbsp;31, 2025;</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(3)</TD><TD>Registrant&rsquo;s Current Reports on Form&nbsp;8-K filed on <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/879169/000087916925000011/incy-20250106.htm" STYLE="-sec-extract: exhibit">January&nbsp;10, 2025</A>, <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/879169/000087916925000059/incy-20250511.htm" STYLE="-sec-extract: exhibit">May&nbsp;14, 2025</A> and <A HREF="https://www.sec.gov/ix?doc=/Archives/edgar/data/879169/000087916925000062/incy-20250610.htm" STYLE="-sec-extract: exhibit">June&nbsp;11, 2025</A>; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">(4)</TD><TD>The description of the Common Stock contained in Registrant&rsquo;s Registration Statement on Form&nbsp;8-A filed January&nbsp;5,
1996.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition, all documents subsequently filed by
Registrant pursuant to Section&nbsp;13(a), 13(c), 14 or 15(d)&nbsp;of the Securities Exchange Act of 1934, prior to the filing of a post-effective
amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall
be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of filing of such documents.
The Registrant is not, however, incorporating, in each case, any documents or information that the Registrant is deemed to furnish and
not file in accordance with Securities and Exchange Commission rules.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Any statement contained in
this Registration Statement or in a document incorporated by reference in this Registration Statement shall be deemed to be modified or
superseded for purposes of this Registration Statement to the extent that a statement contained in this Registration Statement or in any
subsequently filed document that is deemed to be incorporated by reference in this Registration Statement modifies or supersedes such
statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.5in"><B>Item 8.</B></TD><TD><B>Exhibits</B></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 1.3in; text-align: center">Exhibit</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><U>Number</U></TD>
    <TD><U>Exhibit</U></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><A HREF="tm2517983d2_ex5-1.htm" STYLE="-sec-extract: exhibit">5.1</A></TD>
    <TD STYLE="text-align: left"><A HREF="tm2517983d2_ex5-1.htm" STYLE="-sec-extract: exhibit">Opinion of Pillsbury Winthrop Shaw Pittman LLP.</A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><A HREF="tm2517983d2_ex23-1.htm" STYLE="-sec-extract: exhibit">23.1</A></TD>
    <TD><A HREF="tm2517983d2_ex23-1.htm" STYLE="-sec-extract: exhibit">Consent of Ernst&nbsp;&amp; Young LLP,&nbsp;Independent Registered Public Accounting Firm.</A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><A HREF="tm2517983d2_ex5-1.htm" STYLE="-sec-extract: exhibit">23.2</A></TD>
    <TD><A HREF="tm2517983d2_ex5-1.htm" STYLE="-sec-extract: exhibit">Consent of Pillsbury Winthrop Shaw Pittman LLP (included in Exhibit&nbsp;5.1).</A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><A HREF="#a_001">24.1</A></TD>
    <TD><A HREF="#a_001">Power of Attorney (included on the signature page&nbsp;hereto).</A></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><A HREF="tm2517983d2_ex-filingfees.htm" STYLE="-sec-extract: exhibit">107.1</A></TD>
    <TD><A HREF="tm2517983d2_ex-filingfees.htm" STYLE="-sec-extract: exhibit">Calculation of Filing Fee Tables</A></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>SIGNATURES</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form&nbsp;S-8,
and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City
of Wilmington, State of Delaware, on June&nbsp;18, 2025.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">INCYTE CORPORATION</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 50%"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 3%"><FONT STYLE="font-size: 10pt">By</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 47%"><FONT STYLE="font-size: 10pt">/s/ Herv&eacute; Hoppenot</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">Herv&eacute; Hoppenot</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">President and Chief Executive Officer</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">(Principal Executive Officer)</FONT></TD></TR>
  </TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_001"></A><U>POWER OF ATTORNEY</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">KNOW ALL MEN BY THESE PRESENTS, that each person
whose signature appears below constitutes and appoints Herv&eacute; Hoppenot, Christiana Stamoulis, and Sheila Denton, and each of them,
his or her true and lawful attorneys-in-fact and agents, each with full power of substitution and re-substitution, for him or her and
in his or her name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to
this Registration Statement, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities
and Exchange Commission granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform
each and every act and thing requisite and necessary to be done, as fully to all intents and purposes as he or she might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or her substitute or substitutes, may do or
cause to be done by virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
<TD STYLE="border-bottom: Black 1pt solid; text-align: center; width: 30%"><B>Signature</B></TD>
<TD STYLE="text-align: center; width: 1%">&nbsp;</TD>
<TD STYLE="border-bottom: Black 1pt solid; text-align: center; width: 50%"><B>Title</B></TD>
    <TD STYLE="text-align: center; width: 1%">&nbsp;</TD>
<TD STYLE="border-bottom: Black 1pt solid; text-align: center; width: 18%"><B>Date</B></TD></TR>
<TR STYLE="vertical-align: bottom">
<TD STYLE="text-align: center">&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Herv&eacute; Hoppenot</TD>
<TD>&nbsp;</TD>
<TD>President and Chief Executive Officer </TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: center">Herv&eacute; Hoppenot <B>&nbsp;</B></TD>
<TD>&nbsp;</TD>
<TD>(Principal Executive Officer) and Chairman</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: center">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Christiana Stamoulis <B>&nbsp;</B></TD>
<TD>&nbsp;</TD>
<TD>Executive Vice President and Chief Financial Officer </TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: center">Christiana Stamoulis </TD>
<TD>&nbsp;</TD>
<TD>(Principal Financial Officer)</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: center">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Thomas R. Tray</TD>
<TD>&nbsp;</TD>
<TD>Vice President and Chief Accounting Officer </TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: center">Thomas R. Tray <B>&nbsp;</B></TD>
<TD>&nbsp;</TD>
<TD>(Principal Accounting Officer)</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: center">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Julian C. Baker</TD>
<TD>&nbsp;</TD>
<TD>Director</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR>
<TD STYLE="text-align: center">Julian C. Baker</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="text-align: center">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Jean-Jacques Bienaim&eacute;</TD>
<TD>&nbsp;</TD>
<TD>Director</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR>
<TD STYLE="text-align: center">Jean-Jacques Bienaim&eacute;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="text-align: center">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Otis W. Brawley</TD>
<TD>&nbsp;</TD>
<TD>Director</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR>
<TD STYLE="text-align: center">Otis W. Brawley</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="text-align: center">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Paul J. Clancy</TD>
<TD>&nbsp;</TD>
<TD>Director</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR>
<TD STYLE="text-align: center">Paul J. Clancy</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="text-align: center">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Jacqualyn A. Fouse</TD>
<TD>&nbsp;</TD>
<TD>Director</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR>
<TD STYLE="text-align: center">Jacqualyn A. Fouse</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="text-align: center">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Edmund P. Harrigan</TD>
<TD>&nbsp;</TD>
<TD>Director</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR>
<TD STYLE="text-align: center">Edmund P. Harrigan</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="text-align: center">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Katherine A. High</TD>
<TD>&nbsp;</TD>
<TD>Director</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR>
<TD STYLE="text-align: center">Katherine A. High</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="text-align: center">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
<TR>
<TD STYLE="border-bottom: Black 1pt solid; text-align: center">/s/ Susanne Schaffert</TD>
<TD>&nbsp;</TD>
<TD>Director</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">June&nbsp;18, 2025</TD></TR>
<TR>
<TD STYLE="text-align: center">Susanne Schaffert</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
<TD STYLE="text-align: center">&nbsp;</TD></TR>
</TABLE>

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[{"type": "S-8", "sequence": "1", "filename": "tm2517983d2_s8.htm", "description": "FORM S-8", "secsgml_size_bytes": 37695}]
{"company-data": {"conformed-name": "INCYTE CORP", "cik": "0000879169", "assigned-sic": "8731", "organization-name": "08 Industrial Applications and Services", "ein": "943136539", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-288139", "film-number": "251056795"}, "business-address": {"street1": "1801 AUGUSTINE CUT-OFF", "city": "WILMINGTON", "state": "DE", "zip": "19803", "phone": "3024986700"}, "mail-address": {"street1": "1801 AUGUSTINE CUT-OFF", "city": "WILMINGTON", "state": "DE", "zip": "19803"}, "former-company": [{"former-conformed-name": "INCYTE CORP", "date-changed": "20030318"}, {"former-conformed-name": "INCYTE GENOMICS INC", "date-changed": "20000710"}, {"former-conformed-name": "INCYTE PHARMACEUTICALS INC", "date-changed": "19930902"}]}
As filed with the Securities and Exchange Commission
on June 18, 2025.
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
INCYTE CORPORATION
(Exact name of registrant as specified in its charter)
Delaware
94-3136539
(State or other jurisdiction of
(I.R.S. Employer
incorporation or organization)
Identification No.)
1801 Augustine Cut-Off
Wilmington, Delaware
19803
(Address of Principal Executive Offices)
(Zip Code)
1997 EMPLOYEE STOCK PURCHASE PLAN OF
INCYTE CORPORATION
(Full title of the plan)
HERVÉ HOPPENOT
Copy to:
President and Chief Executive Officer
STANTON D. WONG
Incyte Corporation
Pillsbury Winthrop Shaw Pittman LLP
1801 Augustine Cut-Off
Wilmington, Delaware
(302) 498-6700
Four Embarcadero Center, 22nd Floor
San Francisco, California 94111
(415) 983-1000
(Name, address and telephone number,
including area code, of agent for service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
x
Accelerated filer
¨
Non-accelerated filer
¨
(Do not check if a smaller reporting
    company)
Smaller reporting company
¨
Emerging growth company
¨
If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 7(a)(2)(B) of the Securities Act.
¨
PART I
INFORMATION REQUIRED PURSUANT
TO GENERAL INSTRUCTION E TO FORM S-8
General Instruction E Information
This registration statement (the "Registration
Statement") is being filed for the purpose of increasing the number of securities of the same class as other securities for which
a Registration Statement of Incyte Corporation (the "Registrant") on Form S-8 relating to the same employee benefit plan
is effective.
The Registrant's Form S-8 Registration
Statements filed with the Securities and Exchange Commission on
July 16, 1997 (File No. 333-31409)
,
October 3, 2000 (File No. 333-47180)
,
August 15, 2001 (File No. 333-67596)
,
June 28, 2002 (File No. 333-91540)
,
August 15, 2003
(File No. 333-108013)
,
May 25, 2006 (File No. 333-134472)
,
June 17, 2008 (File No. 333-151715)
,
June 16, 2009 (File No. 333-160007)
,
June 15, 2010 (File No. 333-167528)
,
June 15, 2011 (File No. 333-174919)
,
June 17, 2016 (File No. 333-212102)
,
June 15, 2020 (File No. 333-239162)
, and
June 30, 2023 (333-273056)
are hereby incorporated by reference.
Part II
Information Required in the Registration Statement
Item 3.
Incorporation of Documents by Reference.
The following documents previously filed by Registrant
with the Securities and Exchange Commission are hereby incorporated by reference in this Registration Statement:
(1)
Registrant's Annual Report on Form 10-K for the year ended December 31, 2024;
(2)
Registrant's Quarterly Report on Form 10-Q for the quarter ended March 31, 2025;
(3)
Registrant's Current Reports on Form 8-K filed on
January 10, 2025
,
May 14, 2025
and
June 11, 2025
; and
(4)
The description of the Common Stock contained in Registrant's Registration Statement on Form 8-A filed January 5,
1996.
In addition, all documents subsequently filed by
Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, prior to the filing of a post-effective
amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall
be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of filing of such documents.
The Registrant is not, however, incorporating, in each case, any documents or information that the Registrant is deemed to furnish and
not file in accordance with Securities and Exchange Commission rules.
Any statement contained in
this Registration Statement or in a document incorporated by reference in this Registration Statement shall be deemed to be modified or
superseded for purposes of this Registration Statement to the extent that a statement contained in this Registration Statement or in any
subsequently filed document that is deemed to be incorporated by reference in this Registration Statement modifies or supersedes such
statement.
-
1
-
Item 8.
Exhibits
Exhibit
Number
Exhibit
5.1
Opinion of Pillsbury Winthrop Shaw Pittman LLP.
23.1
Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Pillsbury Winthrop Shaw Pittman LLP (included in Exhibit 5.1).
24.1
Power of Attorney (included on the signature page hereto).
107.1
Calculation of Filing Fee Tables
-
2
-
SIGNATURES
Pursuant to the requirements of the Securities
Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8,
and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City
of Wilmington, State of Delaware, on June 18, 2025.
INCYTE CORPORATION
By
/s/ Hervé Hoppenot
Hervé Hoppenot
President and Chief Executive Officer
(Principal Executive Officer)
POWER OF ATTORNEY
KNOW ALL MEN BY THESE PRESENTS, that each person
whose signature appears below constitutes and appoints Hervé Hoppenot, Christiana Stamoulis, and Sheila Denton, and each of them,
his or her true and lawful attorneys-in-fact and agents, each with full power of substitution and re-substitution, for him or her and
in his or her name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to
this Registration Statement, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities
and Exchange Commission granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform
each and every act and thing requisite and necessary to be done, as fully to all intents and purposes as he or she might or could do in
person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or her substitute or substitutes, may do or
cause to be done by virtue hereof.
Pursuant to the requirements of the Securities
Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated:
Signature
Title
Date
/s/ Hervé Hoppenot
President and Chief Executive Officer
June 18, 2025
Hervé Hoppenot
(Principal Executive Officer) and Chairman
/s/ Christiana Stamoulis
Executive Vice President and Chief Financial Officer
June 18, 2025
Christiana Stamoulis
(Principal Financial Officer)
/s/ Thomas R. Tray
Vice President and Chief Accounting Officer
June 18, 2025
Thomas R. Tray
(Principal Accounting Officer)
/s/ Julian C. Baker
Director
June 18, 2025
Julian C. Baker
/s/ Jean-Jacques Bienaimé
Director
June 18, 2025
Jean-Jacques Bienaimé
/s/ Otis W. Brawley
Director
June 18, 2025
Otis W. Brawley
/s/ Paul J. Clancy
Director
June 18, 2025
Paul J. Clancy
/s/ Jacqualyn A. Fouse
Director
June 18, 2025
Jacqualyn A. Fouse
/s/ Edmund P. Harrigan
Director
June 18, 2025
Edmund P. Harrigan
/s/ Katherine A. High
Director
June 18, 2025
Katherine A. High
/s/ Susanne Schaffert
Director
June 18, 2025
Susanne Schaffert
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