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      <div style="text-align: center; color: #000000; font-weight: bold;">As filed with the Securities and Exchange Commission on July 29, 2019</div>
      <div style="text-align: right; color: #000000; font-weight: bold;">Registration No. 333-&#160; &#160; &#160; &#160; &#160; </div>
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    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="text-align: center; color: #000000; font-weight: bold;"> <br>
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      <div>&#160;</div>
      <div style="color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="color: #000000; font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="color: #000000; font-style: italic; font-weight: bold;">UNDER</div>
      <div style="color: #000000; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div style="color: #000000; font-style: italic; font-weight: bold;"> <br>
      </div>
      <div style="color: #000000; font-style: italic; font-weight: bold;">
        <hr style="height: 2px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
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        <div><br>
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        <div style="color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold; font-style: normal;">Castle Biosciences, Inc.</div>
        <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">(Exact name of registrant as specified in its charter)</div>
        <div style="color: #000000; font-weight: bold;"> <br>
        </div>
        <div style="color: #000000; font-weight: bold;">
          <hr style="height: 2px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"> </div>
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          <div> <br>
          </div>
          <table id="z2909d64b7c904b6c98ee74a38772bf6a" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

              <tr>
                <td style="width: 49%; vertical-align: top;">
                  <div style="text-align: center; color: #000000; font-weight: bold;">Delaware</div>
                </td>
                <td style="width: 2%; vertical-align: bottom;">&#160;</td>
                <td style="width: 49%; vertical-align: top;">
                  <div style="text-align: center; color: #000000; font-weight: bold;">77-0701774</div>
                </td>
              </tr>
              <tr>
                <td style="width: 49%; vertical-align: top;">
                  <div style="text-align: center; color: #000000; font-weight: bold;">(State or other jurisdiction of incorporation or organization)</div>
                </td>
                <td style="width: 2%; vertical-align: bottom;">&#160;</td>
                <td style="width: 49%; vertical-align: top;">
                  <div style="text-align: center; color: #000000; font-weight: bold;">(I.R.S. Employer Identification No.)</div>
                </td>
              </tr>
              <tr>
                <td style="width: 49%; vertical-align: middle;">&#160;</td>
                <td style="vertical-align: middle;" colspan="2">&#160;</td>
              </tr>
              <tr>
                <td style="width: 49%; vertical-align: top;">
                  <div style="text-align: center; color: #000000; font-weight: bold;">820 S. Friendswood Drive, Suite 201</div>
                  <div style="text-align: center; color: #000000; font-weight: bold;">Friendswood, Texas</div>
                </td>
                <td style="width: 2%; vertical-align: bottom;">&#160;</td>
                <td style="width: 49%; vertical-align: bottom;">
                  <div style="text-align: center; color: #000000; font-weight: bold;">77546</div>
                </td>
              </tr>
              <tr>
                <td style="width: 49%; vertical-align: top;">
                  <div style="text-align: center; color: #000000; font-weight: bold;">(Address of Principal Executive Offices)</div>
                </td>
                <td style="width: 2%; vertical-align: bottom;">&#160;</td>
                <td style="width: 49%; vertical-align: top;">
                  <div style="text-align: center; color: #000000; font-weight: bold;">(Zip Code)</div>
                </td>
              </tr>

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            <div style="font-weight: bold; font-style: normal;">2008 Stock Plan</div>
            <font style="font-style: normal;"> </font>
            <div style="font-weight: bold; font-style: normal;">2018 Equity Incentive Plan</div>
            <font style="font-style: normal;"> </font>
            <div style="font-weight: bold; font-style: normal;">2019 Equity Incentive Plan</div>
            <font style="font-style: normal;"> </font>
            <div style="font-weight: bold; font-style: normal;">2019 Employee Stock Purchase Plan</div>
            <font style="font-style: normal;"> </font>
            <div><font style="font-style: normal;"><br>
              </font> </div>
            <font style="font-style: normal;"> </font>
            <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">(Full titles of the plans)</div>
            <div style="color: #000000; font-weight: bold;"> <br>
            </div>
            <div style="color: #000000; font-weight: bold;">
              <div>
                <hr style="height: 2px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
              <div style="font-style: normal;">&#160;</div>
              <font style="font-style: normal;"> </font>
              <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">Derek Maetzold</div>
              <font style="font-style: normal;"> </font>
              <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">President and Chief Executive Officer</div>
              <font style="font-style: normal;"> </font>
              <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">Castle Biosciences, Inc.</div>
              <font style="font-style: normal;"> </font>
              <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">820 S. Friendswood Drive, Suite 201</div>
              <font style="font-style: normal;"> </font>
              <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">Friendswood, Texas 77546</div>
              <font style="font-style: normal;"> </font>
              <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">(866) 788-9007</div>
              <font style="font-style: normal;"> </font>
              <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
              <div style="color: #000000; font-weight: bold;"> <br>
              </div>
              <div style="color: #000000; font-weight: bold;">
                <div>
                  <hr style="height: 2px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
                <div>&#160;</div>
                <div style="color: rgb(0, 0, 0); font-style: normal; font-weight: bold;">Copies to:</div>
                <font style="font-style: normal;"> </font>
                <div style="color: #000000; font-style: italic; font-weight: bold;"> <font style="font-style: normal;"><br>
                  </font> </div>
                <font style="font-style: normal;"> </font>
                <div style="color: #000000; font-style: italic; font-weight: bold;"><font style="font-style: normal;"> </font>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">Thomas A. Coll, Esq.</div>
                  <font style="font-style: normal;"> </font>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">Karen E. Anderson, Esq.</div>
                  <font style="font-style: normal;"> </font>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">Cooley LLP</div>
                  <font style="font-style: normal;"> </font>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">4401 Eastgate Mall</div>
                  <font style="font-style: normal;"> </font>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">San Diego, California 92121</div>
                  <font style="font-style: normal;"> </font>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">(858) 550-6000</div>
                  <font style="font-style: normal;"> </font>
                  <div style="color: #000000; font-weight: bold;"><font style="font-style: normal;"> </font><br>
                  </div>
                  <div style="color: #000000; font-weight: bold;">
                    <hr style="height: 2px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
                  <div>&#160;</div>
                </div>
                <div style="color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">
                  <div style="text-align: justify;">I<font style="font-weight: normal; font-style: normal;">ndicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company,
                      or an emerging growth company. See the definitions of <font style="color: rgb(0, 0, 0);">&#8220;</font>large accelerated filer,<font style="color: rgb(0, 0, 0);">&#8221;</font>&#160;<font style="color: rgb(0, 0, 0);">&#8220;</font>accelerated filer,<font style="color: rgb(0, 0, 0);">&#8221;</font>&#160;<font style="color: rgb(0, 0, 0);">&#8220;</font>smaller reporting company,<font style="color: rgb(0, 0, 0);">&#8221;</font> and <font style="color: rgb(0, 0, 0);">&#8220;</font>emerging growth company<font style="color: rgb(0, 0, 0);">&#8221;</font> in Rule 12b-2 of the Exchange Act.</font></div>
                  <div style="text-align: justify;"><font style="font-weight: normal; font-style: normal;"> <br>
                    </font></div>
                  <table id="z01cdd2a6d17942e6881c36c4c74dd99d" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                      <tr>
                        <td style="width: 16.67%; vertical-align: bottom; font-weight: normal; font-style: normal;">
                          <div style="text-align: justify;">Large Accelerated filer</div>
                        </td>
                        <td style="width: 1.37%; vertical-align: bottom; font-weight: normal; font-style: normal;">&#160;</td>
                        <td style="width: 56.78%; vertical-align: bottom; font-weight: normal; font-style: normal;">&#9744;</td>
                        <td style="width: 1.37%; vertical-align: bottom; font-weight: normal; font-style: normal;">&#160;</td>
                        <td style="width: 19.54%; vertical-align: bottom; font-weight: normal; font-style: normal;">
                          <div style="text-align: justify;">Accelerated filer</div>
                        </td>
                        <td style="width: 1.37%; vertical-align: bottom; font-weight: normal; font-style: normal;">&#160;</td>
                        <td style="width: 2.89%; vertical-align: bottom; font-weight: normal; font-style: normal;">&#9744;</td>
                      </tr>
                      <tr>
                        <td style="width: 16.67%; vertical-align: middle; font-weight: normal; font-style: normal;">&#160;</td>
                        <td style="width: 58.16%; vertical-align: middle; font-weight: normal; font-style: normal;" colspan="2">&#160;</td>
                        <td style="width: 20.91%; vertical-align: middle; font-weight: normal; font-style: normal;" colspan="2">&#160;</td>
                        <td style="width: 4.27%; vertical-align: middle; font-weight: normal; font-style: normal;" colspan="2">&#160;</td>
                      </tr>
                      <tr>
                        <td style="width: 16.67%; vertical-align: bottom; font-weight: normal; font-style: normal;">
                          <div style="text-align: justify;">Non-accelerated filer</div>
                        </td>
                        <td style="width: 1.37%; vertical-align: bottom; font-weight: normal; font-style: normal;">&#160;</td>
                        <td style="width: 56.78%; vertical-align: bottom; font-weight: normal; font-style: normal;">&#9746;</td>
                        <td style="width: 1.37%; vertical-align: bottom; font-weight: normal; font-style: normal;">&#160;</td>
                        <td style="width: 19.54%; vertical-align: bottom; font-weight: normal; font-style: normal;">
                          <div style="text-align: justify;">Smaller reporting company</div>
                        </td>
                        <td style="width: 1.37%; vertical-align: bottom; font-weight: normal; font-style: normal;">&#160;</td>
                        <td style="width: 2.89%; vertical-align: bottom; font-weight: normal; font-style: normal;">&#9746;</td>
                      </tr>

                  </table>
                  <div style="font-weight: normal; font-style: normal;">&#160;</div>
                  <div style="text-align: justify; font-weight: normal; font-style: normal;">Emerging growth company &#9746;</div>
                  <div style="font-weight: normal; font-style: normal;">&#160;</div>
                  <div style="text-align: justify; font-weight: normal; font-style: normal;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised
                    financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
                  <div style="text-align: justify; font-weight: normal; font-style: normal;"><font style="font-family: 'Segoe UI Symbol',sans-serif; color: rgb(0, 0, 0);"> <br>
                    </font></div>
                  <div style="text-align: justify; font-weight: normal; font-style: normal;">
                    <hr style="border-width: 1px medium 4px; border-style: solid none; border-color: black -moz-use-text-color; -moz-border-top-colors: none; -moz-border-right-colors: none; -moz-border-bottom-colors: none; -moz-border-left-colors: none; border-image: none; height: 10px; color: rgb(255, 255, 255); background-color: rgb(255, 255, 255); text-align: center;" align="center"><font style="font-family: 'Segoe UI Symbol',sans-serif; color: rgb(0, 0, 0);"> </font></div>
                  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                    <div id="DSPFPageBreak" style="page-break-after: always;">
                      <hr style="margin-top: 4px; margin-bottom: 4px; width: 100%; border-width: 0px; height: 2px; color: rgb(0, 0, 0); background-color: rgb(0, 0, 0); clear: both;" noshade="noshade"></div>
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                  <div style="color: rgb(0, 0, 0); font-weight: normal;">CALCULATION OF REGISTRATION FEE</div>
                  <div style="text-align: left;"><font style="color: rgb(0, 0, 0);"> </font><br>
                  </div>
                  <table id="z4d1033dd739c4a3c97051327d98e1798" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: rgb(0, 0, 0); width: 100%;" border="0" cellpadding="0" cellspacing="0">

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                        <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 44%;" valign="bottom">
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Title of securities</div>
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">to be registered</div>
                        </td>
                        <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 20%;" valign="bottom">
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Amount</div>
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">to be</div>
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">registered (1)</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%;" valign="bottom">&#160;</td>
                        <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Proposed</div>
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">maximum</div>
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">offering price</div>
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">per share</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%;" nowrap="nowrap" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%;" valign="bottom">&#160;</td>
                        <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Proposed</div>
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">maximum</div>
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">aggregate</div>
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">offering price</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%;" nowrap="nowrap" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%;" valign="bottom">&#160;</td>
                        <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Amount of</div>
                          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">registration fee</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" nowrap="nowrap" valign="bottom">&#160;</td>
                      </tr>
                      <tr>
                        <td style="vertical-align: top; width: 44%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="text-indent: -9pt; margin-left: 9pt;"><font style="font-weight: bold;">2008 Stock Plan</font> Common Stock, $0.001 par value per share</div>
                        </td>
                        <td style="vertical-align: bottom; width: 20%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="text-align: center;">853,202 shares<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
                          <div>$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
                          <div>2.17</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
                          <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup>&#160;</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
                          <div>$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
                          <div>1,851,448.34</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
                          <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup>&#160;</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
                          <div>$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
                          <div>224.40</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" nowrap="nowrap" valign="bottom">&#160;</td>
                      </tr>
                      <tr>
                        <td style="vertical-align: top; width: 44%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="text-indent: -9pt; margin-left: 9pt;"><font style="font-weight: bold; color: rgb(0, 0, 0);">2018 Equity Incentive Plan </font>Common Stock, $0.001 par value per share</div>
                        </td>
                        <td style="vertical-align: bottom; width: 20%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="text-align: center;">646,526 shares<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>3.23</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
                          <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(5)</sup>&#160;</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>2,088,278.98</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
                          <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(5)</sup>&#160;</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>253.10</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(255, 255, 255);" nowrap="nowrap" valign="bottom">&#160;</td>
                      </tr>
                      <tr>
                        <td style="vertical-align: top; width: 44%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="text-indent: -9pt; margin-left: 9pt;"><font style="font-weight: bold; color: rgb(0, 0, 0);">2019 Equity Incentive Plan </font>Common Stock, $0.001 par value per share</div>
                        </td>
                        <td style="vertical-align: bottom; width: 20%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="text-align: center;">3,534,654 shares<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(6)</sup></div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">$</td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">19.55</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(7)</sup>&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
                          <div>$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
                          <div>69,102,485.70</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
                          <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(7)</sup>&#160;</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
                          <div>$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
                          <div>8,375.23</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" nowrap="nowrap" valign="bottom">&#160;</td>
                      </tr>
                      <tr>
                        <td style="vertical-align: top; width: 44%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="color: rgb(0, 0, 0); font-weight: bold;">
                            <div style="text-indent: -9pt; margin-left: 9pt;">2019 Employee Stock Purchase Plan <font style="font-weight: normal;">Common Stock, $0.001 par value per share</font></div>
                          </div>
                        </td>
                        <td style="vertical-align: bottom; width: 20%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="text-align: center;">411,935 shares<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(8)</sup></div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom"><br>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">$</td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>19.55</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
                          <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(7)</sup>&#160;</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom"><br>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>8,053,329.25</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
                          <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(7)</sup>&#160;</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom"><br>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" valign="bottom">
                          <div>976.07</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(255, 255, 255);" nowrap="nowrap" valign="bottom"><br>
                        </td>
                      </tr>
                      <tr>
                        <td style="vertical-align: top; width: 44%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold; text-indent: -9pt; margin-left: 9pt;">Total:</div>
                        </td>
                        <td style="vertical-align: bottom; width: 20%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="text-align: center; font-weight: bold;">5,446,317 shares</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom"><br>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="font-weight: bold;">N/A</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="font-weight: bold;">$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="font-weight: bold;">81,095,542.27</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="font-weight: bold;">$</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
                          <div style="font-weight: bold;">9,828.80</div>
                        </td>
                        <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" nowrap="nowrap" valign="bottom">&#160;</td>
                      </tr>

                  </table>
                  <div>
                    <div style="text-align: left; color: rgb(0, 0, 0); font-weight: bold;"> <br>
                    </div>
                    <div style="text-align: left; color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">Total:</div>
                  </div>
                  <br>
                  <div style="text-align: left;">
                    <div>
                      <table id="zb35b4079aa724e1d81bd9f562538c0a1" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 17.7pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
                            <td style="width: auto; vertical-align: top;">
                              <div>Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), this Registration Statement shall also cover any additional shares of Common Stock (&#8220;Common Stock&#8221;) of Castle Biosciences, Inc.
                                (the &#8220;Registrant&#8221;) that become issuable under the Registrant&#8217;s 2008 Stock Plan (the &#8220;2008 Plan&#8221;), the Registrant&#8217;s 2018 Equity Incentive Plan, as amended (the &#8220;2018 Plan&#8221;), the Registrant&#8217;s 2019 Equity Incentive Plan (the
                                &#8220;2019 Plan&#8221;), or the Registrant&#8217;s 2019 Employee Stock Purchase Plan (the &#8220;2019 ESPP&#8221;) by reason of any stock dividend, stock split, recapitalization or other similar transaction.</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                  <div style="text-align: left;">
                    <div>
                      <table id="z1d3439fcad0e40f89af1db88487f80e2" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 18pt; vertical-align: top;">(2)</td>
                            <td style="width: auto; vertical-align: top;">
                              <div>Represents shares of Common Stock reserved for issuance upon the exercise of outstanding stock options granted under the 2008 Plan. No additional stock awards will be granted under the 2008 Plan, and any shares underlying
                                then-outstanding stock awards granted under the 2008 Plan that, on or after July 24, 2019 expire or terminate for any reason prior to exercise or settlement, or are forfeited because of the failure to meet a contingency or
                                condition required to vest such shares, or otherwise return to the Registrant or are reacquired, withheld or not issued to satisfy a tax withholding obligation in connection with an award or to satisfy the purchase price or
                                exercise price of a stock award (such shares, the <font style="color: rgb(0, 0, 0);">&#8220;</font>2008 Plan Returning Shares<font style="color: rgb(0, 0, 0);">&#8221;</font>), will become available for the grant of stock awards under
                                the 2019 Plan.</div>
                            </td>
                          </tr>

                      </table>
                      <div> <br>
                      </div>
                    </div>
                  </div>
                  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                    <div id="DSPFPageBreak" style="page-break-after: always;">
                      <hr style="margin-top: 4px; margin-bottom: 4px; width: 100%; border-width: 0px; height: 2px; color: rgb(0, 0, 0); background-color: rgb(0, 0, 0); clear: both;" noshade="noshade"></div>
                  </div>
                  <div style="text-align: left;">
                    <div>
                      <table id="z8fd00d3e92314f53861cc05006dec40c" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 18pt; vertical-align: top;">(3)</td>
                            <td style="width: auto; vertical-align: top;">
                              <div>Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h)(1) of the Securities Act. The proposed maximum aggregate offering price per share and proposed maximum aggregate
                                offering price for the 853,202 shares of Common Stock reserved for issuance upon the exercise of outstanding stock options granted under the 2008 Plan are calculated using a weighted average exercise price of $2.17 per
                                share.</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                  <div style="text-align: left;">
                    <div>
                      <table id="zb43845d298af46ed980121b8a97d405f" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 18pt; vertical-align: top;">(4)</td>
                            <td style="width: auto; vertical-align: top;">
                              <div>Represents shares of Common Stock reserved for issuance upon the exercise of outstanding stock options granted under the 2018 Plan. No additional stock awards will be granted under the 2018 Plan and the shares remaining
                                available for the grant of future stock awards under the 2018 Plan (the &#8220;2018 Plan Pool&#8221;), plus any shares underlying then-outstanding stock awards granted under the 2018 Plan, that on or after July 24, 2019 expire or
                                terminate for any reason prior to exercise or settlement, or are forfeited because of the failure to meet a contingency or condition required to vest such shares, or otherwise return to the Registrant or are reacquired,
                                withheld or not issued to satisfy a tax withholding obligation in connection with an award or to satisfy the purchase price or exercise price of a stock award (such shares, the <font style="color: rgb(0, 0, 0);">&#8220;</font>2018

















                                Plan Returning Shares,<font style="color: rgb(0, 0, 0);">&#8221; and together with the 2008 Plan Returning Shares, the &#8220;Returning Shares&#8221;</font>), will become available for the grant of stock awards under the 2019 Plan.</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                  <div style="text-align: left;">
                    <div>
                      <table id="z46da38ada29d49398c3ab360daebfb1f" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 17.7pt; vertical-align: top;">(5)</td>
                            <td style="width: auto; vertical-align: top;">
                              <div>Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h)(1) of the Securities Act. The proposed maximum aggregate offering price per share and proposed maximum aggregate
                                offering price for the 646,526 shares of Common Stock reserved for issuance upon the exercise of outstanding stock options granted under the 2018 Plan are calculated using a weighted average exercise price of $3.23 per
                                share.</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                  <div style="text-align: left;">
                    <div>
                      <table id="z03c74843e82944a183962baa2611e7ae" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 17.7pt; vertical-align: top;">(6)</td>
                            <td style="width: auto; vertical-align: top;">
                              <div>Represents the sum of 1,931,020 new shares, plus 103,906 shares in the 2018 Plan Pool and the Returning Shares. The 2019 Plan provides that an additional number of shares will automatically be added to the shares
                                authorized for issuance under the 2019 Plan on January 1<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st</sup> of each calendar year, from January 1, 2020 through January 1, 2029. The number of
                                shares added each year will be equal to the lesser of: (a) 5% of the total number of shares of capital stock of the Registrant outstanding on December 31 of the preceding calendar year; or (b) such lesser number of shares of
                                Common Stock as the Registrant<font style="color: rgb(0, 0, 0);">&#8217;</font>s board of directors (the <font style="color: rgb(0, 0, 0);">&#8220;</font>Board<font style="color: rgb(0, 0, 0);">&#8221;</font>) may designate prior to the
                                applicable January 1<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st</sup>.</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                  <div style="text-align: left;">
                    <div>
                      <table id="zc68f95eea9464667abf60efcb8e8c49c" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 17.7pt; vertical-align: top;">(7)</td>
                            <td style="width: auto; vertical-align: top;">
                              <div>This estimate is made pursuant to Rule 457(h)(1) and Rule 457 (c) of the Securities Act solely for purposes of calculating the registration fee, and is based on the average of the high and low prices of the Common Stock
                                as reported on the Nasdaq Global Market for July 25, 2019.</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                  <div style="text-align: left;">
                    <div>
                      <table id="z37b1e8fdd9d24128918eba1870af6d2a" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 18pt; vertical-align: top;">(8)</td>
                            <td style="width: auto; vertical-align: top;">
                              <div>Represents 411,935 shares of Common Stock reserved for future grant under the 2019 ESPP. The 2019 ESPP provides that an additional number of shares will automatically be added to the shares authorized for issuance under
                                the 2019 ESPP on January 1<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st</sup> of each calendar year, from January 1, 2020 through January 1, 2029. The number of shares of Common Stock added
                                each year will be equal to the lesser of: (a) 1% of the total number of shares of capital stock outstanding on December 31 of the preceding calendar year; (b) 411,935 shares; or (c) such lesser number of shares of Common
                                Stock as the Board may designate prior to the applicable January 1<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">st</sup>.</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                  <div style="text-align: left;"> <br>
                  </div>
                  <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
                    <div style="page-break-after: always;" id="DSPFPageBreak">
                      <hr style="border-width: 0px; clear: both; margin-top: 4px; margin-bottom: 4px; width: 100%; height: 2px; color: rgb(0, 0, 0); background-color: rgb(0, 0, 0);" noshade="noshade"></div>
                  </div>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">PART I</div>
                  <div>&#160;</div>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>
                  <div style="text-align: left;"><font style="color: rgb(0, 0, 0);"> </font><br>
                  </div>
                  <div style="text-align: left;">
                    <div>
                      <div>
                        <div>
                          <table style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="zd3b90c2107ba463c8c48423edee6c092" class="DSPFListTable" cellpadding="0" cellspacing="0">

                              <tr style="vertical-align: top;">
                                <td style="vertical-align: top; width: 54pt;">
                                  <div style="color: rgb(0, 0, 0); font-weight: bold;">ITEM 1.</div>
                                </td>
                                <td style="vertical-align: top; width: auto;">
                                  <div style="color: rgb(0, 0, 0); font-weight: bold;">PLAN INFORMATION.</div>
                                </td>
                              </tr>

                          </table>
                        </div>
                      </div>
                    </div>
                  </div>
                  <div>&#160;</div>
                  <div style="text-align: justify; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;">Not required to be filed with this Registration Statement.</div>
                  <div style="text-align: left;"><font style="color: rgb(0, 0, 0);"> </font><br>
                  </div>
                  <div style="text-align: left;">
                    <div>
                      <div>
                        <div>
                          <table style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="zd717c004011a473891053a79071f61bb" class="DSPFListTable" cellpadding="0" cellspacing="0">

                              <tr style="vertical-align: top;">
                                <td style="vertical-align: top; width: 54pt;">
                                  <div style="color: rgb(0, 0, 0); font-weight: bold;">ITEM 2.</div>
                                </td>
                                <td style="vertical-align: top; width: auto;">
                                  <div style="color: rgb(0, 0, 0); font-weight: bold;">REGISTRANT INFORMATION AND EMPLOYEE PLAN ANNUAL INFORMATION.</div>
                                </td>
                              </tr>

                          </table>
                        </div>
                      </div>
                    </div>
                  </div>
                  <div>&#160;</div>
                  <div style="text-align: justify; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;">Not required to be filed with this Registration Statement.</div>
                  <div style="text-align: justify; color: rgb(0, 0, 0);"> <br>
                  </div>
                  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                    <div id="DSPFPageBreak" style="page-break-after: always;">
                      <hr style="margin-top: 4px; margin-bottom: 4px; width: 100%; border-width: 0px; height: 2px; color: rgb(0, 0, 0); background-color: rgb(0, 0, 0); clear: both;" noshade="noshade"></div>
                  </div>
                  <font style="font-style: normal;"> </font>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">PART II</div>
                  <font style="font-style: normal;"> </font>
                  <div style="font-style: normal;">&#160;</div>
                  <font style="font-style: normal;"> </font>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: left;"><font style="color: rgb(0, 0, 0); font-style: normal;"> </font><br>
                  </div>
                  <div style="text-align: left;">
                    <div>
                      <div>
                        <div>
                          <table style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z24ec473fe4624f14868298907f46b1e9" class="DSPFListTable" cellpadding="0" cellspacing="0">

                              <tr style="vertical-align: top;">
                                <td style="vertical-align: top; width: 54pt;">
                                  <div style="color: rgb(0, 0, 0); font-weight: bold;">ITEM 3.</div>
                                </td>
                                <td style="vertical-align: top; width: auto;">
                                  <div style="color: rgb(0, 0, 0); font-weight: bold;">INCORPORATION OF DOCUMENTS BY REFERENCE.</div>
                                </td>
                              </tr>

                          </table>
                        </div>
                      </div>
                    </div>
                  </div>
                  <div><br>
                  </div>
                  <div style="font-style: normal;">&#160;</div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed by the Registrant with the Securities and
                    Exchange Commission (&#8220;SEC&#8221;):</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="font-style: normal; font-weight: normal;">&#160;</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="text-align: justify;"><font style="font-weight: bold; color: rgb(0, 0, 0); font-style: normal;">(a)</font><font style="font-style: normal; font-weight: normal;"> The Registrant<font style="color: rgb(0, 0, 0);">&#8217;</font>s <a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119013449/nt10000802x12_424b4.htm">prospectus</a> dated July 24, 2019 and filed on July 26, 2019 pursuant to Rule 424(b) under the Securities Act, which contains audited
                      financial statements for the Registrant<font style="color: rgb(0, 0, 0);">&#8217;</font>s latest fiscal year for which such statements have been filed, relating to the registration statement on <a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119013220/nt10000802x9_s1a.htm">Form S-1</a> originally filed on June 26, 2019, as amended (File No. 333-232369), and the registration statement on <a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119013393/nt10000802x11_s1mef.htm">Form S-1</a> filed pursuant to Rule 462(b) of the Securities Act filed on July 24, 2019 (File No. 333-232796).</font></div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="font-style: normal; font-weight: normal;">&#160;</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="text-align: justify; color: rgb(0, 0, 0);"><font style="font-weight: normal; font-style: normal;"><font style="font-weight: bold;">(b)</font> </font><font style="font-style: normal; font-weight: normal;">The Registrant&#8217;s
                      Current Report on <a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119013617/nc10003561x1_8k.htm">Form 8-K</a>, filed with the SEC on July 29, 2019.</font></div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="font-style: normal; font-weight: normal;">&#160;</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="text-align: justify;"><font style="font-weight: bold; color: rgb(0, 0, 0); font-style: normal;">(c)</font><font style="font-style: normal; font-weight: normal;"> The description of the Registrant<font style="color: rgb(0, 0, 0);">&#8217;</font>s Common Stock contained in the Registrant<font style="color: rgb(0, 0, 0);">&#8217;</font>s registration statement on <a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119012956/nc10003252x1_8a12b.htm">Form
                        8-A</a> filed on July 15, 2019 (File No. 001-38984) under the Securities Exchange Act of 1934, as amended (the <font style="color: rgb(0, 0, 0);">&#8220;</font>Exchange Act<font style="color: rgb(0, 0, 0);">&#8221;</font>), including any
                      amendment or report filed for the purpose of updating such description.</font></div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="font-style: normal; font-weight: normal;">&#160;</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">All documents, reports and definitive proxy or information statements filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of
                    this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be
                    incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents; provided, however, that documents, reports and definitive proxy or information statements, or portions
                    thereof, which are furnished and not filed in accordance with the rules of the SEC shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be
                    incorporated herein by reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement herein or in any other subsequently filed document which also is or is deemed to be
                    incorporated by reference herein modifies or supersedes that statement. Any such statement so modified or superseded shall not constitute a part of this Registration Statement, except as so modified or superseded.</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="text-align: left;"><font style="color: rgb(0, 0, 0); font-style: normal; font-weight: normal;"> </font><font style="font-style: normal;"><br>
                    </font> </div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: left;">
                    <div>
                      <table id="zb99eea77ae2849b7adc4fc537cbd28b1" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 54pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">ITEM 4.</td>
                            <td style="width: auto; vertical-align: top;">
                              <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">DESCRIPTION OF SECURITIES.</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                  <font style="font-style: normal;"> </font>
                  <div style="font-style: normal;">&#160;</div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">Not applicable.</div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: left;"><font style="color: rgb(0, 0, 0); font-style: normal;"> </font><font style="font-style: normal;"><br>
                    </font> </div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: left;">
                    <div>
                      <table id="z779f30084d7947098c291381b96b0f34" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 54pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">ITEM 5.</td>
                            <td style="width: auto; vertical-align: top;">
                              <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">INTERESTS OF NAMED EXPERTS AND COUNSEL.</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                  <font style="font-style: normal;"> </font>
                  <div style="font-style: normal;">&#160;</div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">Not applicable.</div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: left;"><font style="color: rgb(0, 0, 0); font-style: normal;"> </font><font style="font-style: normal;"><br>
                    </font> </div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: left;">
                    <div>
                      <table id="ze514e7b7fc2b4efcbeff468fd0b8ba71" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 54pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">ITEM 6.</td>
                            <td style="width: auto; vertical-align: top;">
                              <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">INDEMNIFICATION OF DIRECTORS AND OFFICERS.</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                  <font style="font-style: normal;"> </font>
                  <div style="font-style: normal;">&#160;</div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">The Registrant is incorporated under the laws of the State of Delaware. Section 145 of the Delaware General Corporation Law provides that a Delaware corporation
                    may indemnify any persons who were, are, or are threatened to be made, parties to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in
                    the right of such corporation), by reason of the fact that such person is or was an officer, director, employee or agent of such corporation, or is or was serving at the request of such corporation as an officer, director, employee or
                    agent of another corporation or enterprise. The indemnity may include expenses (including attorneys<font style="color: rgb(0, 0, 0);">&#8217;</font> fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by
                    such person in connection with such action, suit or proceeding, provided that such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation<font style="color: rgb(0, 0, 0);">&#8217;</font>s
                    best interests and, with respect to any criminal action or proceeding, had no reasonable cause to believe that his or her conduct was illegal. A Delaware corporation may indemnify any persons who were, are, or are threatened to be made,
                    a party to any threatened, pending or completed action or suit by or in the right of the corporation by reason of the fact that such person is or was a director, officer, employee or agent of such corporation, or is or was serving at
                    the request of such corporation as a director, officer, employee or agent of another corporation or enterprise. The indemnity may include expenses (including attorneys<font style="color: rgb(0, 0, 0);">&#8217;</font> fees) actually and
                    reasonably incurred by such person in connection with the defense or settlement of such action or suit; provided such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation<font style="color: rgb(0, 0, 0);">&#8217;</font>s best interests, except that no indemnification is permitted without judicial approval if the officer or director is adjudged to be liable to the corporation. Where an officer or director is
                    successful on the merits or otherwise in the defense of any action referred to above, the corporation must indemnify him or her against the expenses (including attorneys<font style="color: rgb(0, 0, 0);">&#8217;</font> fees) actually and
                    reasonably incurred.</div>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;"> <br>
                  </div>
                  <font style="font-style: normal;"> </font>
                  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                    <div id="DSPFPageBreak" style="page-break-after: always;">
                      <hr style="margin-top: 4px; margin-bottom: 4px; width: 100%; border-width: 0px; height: 2px; color: rgb(0, 0, 0); background-color: rgb(0, 0, 0); clear: both;" noshade="noshade"></div>
                  </div>
                  <font style="font-style: normal;"> </font>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">The Registrant<font style="color: rgb(0, 0, 0);">&#8217;</font>s amended and restated certificate of incorporation and amended and restated bylaws provide for the
                    indemnification of its directors and officers to the fullest extent permitted under the Delaware General Corporation Law.</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="font-style: normal; font-weight: normal;">&#160;</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">Section 102(b)(7) of the Delaware General Corporation Law permits a corporation to provide in its certificate of incorporation that a director of the corporation
                    shall not be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duties as a director, except for liability for any:</div>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;"> <br>
                  </div>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">
                    <div style="text-align: left;">
                      <div>
                        <table id="z75214c1835934d90a7478bd1dfa7d439" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                            <tr>
                              <td style="width: 22.5pt;"><br>
                              </td>
                              <td style="width: 22.5pt; vertical-align: top; align: right;"><font style="color: #000000;">&#8226;</font>&#160;</td>
                              <td style="width: auto; vertical-align: top;">
                                <div>transaction from which the director derives an improper personal benefit;</div>
                              </td>
                            </tr>

                        </table>
                      </div>
                    </div>
                  </div>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;"><br>
                  </div>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">
                    <div style="text-align: left;">
                      <div>
                        <table id="z14ab6a33b2434a26a6881b263b63ab3a" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                            <tr>
                              <td style="width: 22.5pt;"><br>
                              </td>
                              <td style="width: 22.5pt; vertical-align: top; align: right;"><font style="color: #000000;">&#8226;</font></td>
                              <td style="width: auto; vertical-align: top;">
                                <div>act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;</div>
                              </td>
                            </tr>

                        </table>
                      </div>
                    </div>
                    <div style="text-align: left; text-indent: -22.5pt; margin-left: 45pt; color: #000000; font-size: 8pt;">&#160;</div>
                    <div style="text-align: left;">
                      <div>
                        <table id="z53df1432cfdf47da926fe009b4f63e21" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                            <tr>
                              <td style="width: 22.5pt;"><br>
                              </td>
                              <td style="width: 22.5pt; vertical-align: top; align: right;"><font style="color: #000000;">&#8226;</font></td>
                              <td style="width: auto; vertical-align: top;">
                                <div>unlawful payment of dividends or redemption of shares; or</div>
                              </td>
                            </tr>

                        </table>
                      </div>
                    </div>
                    <div style="text-align: left; text-indent: -22.5pt; margin-left: 45pt; color: #000000; font-size: 8pt;">&#160;</div>
                    <div style="text-align: left;">
                      <div>
                        <table id="z070a7953dc964346819b1b450d5b28c5" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                            <tr>
                              <td style="width: 22.5pt;"><br>
                              </td>
                              <td style="width: 22.5pt; vertical-align: top; align: right;"><font style="color: #000000;">&#8226;</font></td>
                              <td style="width: auto; vertical-align: top;">
                                <div>breach of a director<font style="color: #000000;">&#8217;</font>s duty of loyalty to the corporation or its stockholders.</div>
                              </td>
                            </tr>

                        </table>
                      </div>
                    </div>
                  </div>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;"><br>
                  </div>
                  <div style="color: rgb(0, 0, 0); font-style: italic; font-weight: bold; text-align: left;"><font style="color: rgb(0, 0, 0); font-style: normal;"> </font><font style="font-style: normal;"></font>
                    <div>
                      <div>
                        <div style="font-weight: normal;">
                          <div> </div>
                        </div>
                      </div>
                    </div>
                    <div>
                      <div> </div>
                    </div>
                    <font style="font-style: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">The Registrant<font style="color: rgb(0, 0, 0);">&#8217;</font>s amended and restated certificate of incorporation includes such a provision. Expenses incurred by any officer or director
                      in defending any such action, suit or proceeding in advance of its final disposition shall be paid by the Registrant upon delivery to it of an undertaking, by or on behalf of such director or officer, to repay all amounts so advanced
                      if it shall ultimately be determined that such director or officer is not entitled to be indemnified by the Registrant.</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">&#160;</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">Section 174 of the Delaware General Corporation Law provides, among other things, that a director who willfully or negligently approves of an unlawful payment of dividends or an
                      unlawful stock purchase or redemption may be held liable for such actions. A director who was either absent when the unlawful actions were approved, or dissented at the time, may avoid liability by causing his or her dissent to such
                      actions to be entered in the books containing minutes of the meetings of the board of directors at the time such action occurred or immediately after such absent director receives notice of the unlawful acts.</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">&#160;</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">As permitted by the Delaware General Corporation Law, the Registrant has entered into indemnity agreements with each of its directors and executive officers, that require the
                      Registrant to indemnify such persons against any and all costs and expenses (including attorneys&#8217;, witness or other professional fees) actually and reasonably incurred by such persons in connection with any action, suit or proceeding
                      (including derivative actions), whether actual or threatened, to which any such person may be made a party by reason of the fact that such person is or was a director or officer or is or was acting or serving as an officer, director,
                      employee or agent of the Registrant or any of its affiliated enterprises. Under these agreements, the Registrant is not required to provide indemnification for certain matters, including:</div>
                    <div style="font-style: normal; font-weight: normal;"> <br>
                    </div>
                    <div style="font-style: normal; font-weight: normal;">
                      <div>
                        <div>
                          <table id="z51cb1b98421c481d8d30aa4b2bf106b4" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                              <tr>
                                <td style="width: 22.5pt;"><br>
                                </td>
                                <td style="width: 22.5pt; vertical-align: top; align: right;">&#8226;</td>
                                <td style="width: auto; vertical-align: top;">
                                  <div>indemnification beyond that permitted by the Delaware General Corporation Law;</div>
                                </td>
                              </tr>

                          </table>
                        </div>
                      </div>
                      <div style="background-color: #FFFFFF;">
                        <div style="text-indent: -22.5pt; margin-left: 45pt;">&#160;</div>
                      </div>
                      <div>
                        <div>
                          <table id="z51a1272599dc4fccbdea0ac3ad09c296" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                              <tr>
                                <td style="width: 22.5pt;"><br>
                                </td>
                                <td style="width: 22.5pt; vertical-align: top; align: right;">&#8226;</td>
                                <td style="width: auto; vertical-align: top;">
                                  <div>indemnification for any proceeding with respect to the unlawful payment of remuneration to the director or officer;</div>
                                </td>
                              </tr>

                          </table>
                        </div>
                      </div>
                      <div style="background-color: #FFFFFF;">
                        <div style="text-indent: -22.5pt; margin-left: 45pt;">&#160;</div>
                      </div>
                      <div>
                        <div>
                          <table id="zc8e252bfd1864bbbb8cc4789e8e5915a" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                              <tr>
                                <td style="width: 22.5pt;"><br>
                                </td>
                                <td style="width: 22.5pt; vertical-align: top; align: right;">&#8226;</td>
                                <td style="width: auto; vertical-align: top;">
                                  <div>indemnification for certain proceedings involving a final judgment that the director or officer is required to disgorge profits from the purchase or sale of the Registrant&#8217;s stock;</div>
                                </td>
                              </tr>

                          </table>
                        </div>
                      </div>
                      <div style="background-color: #FFFFFF;">
                        <div style="text-indent: -22.5pt; margin-left: 45pt;">&#160;</div>
                      </div>
                      <div>
                        <div>
                          <table id="z360443f2f3c64f5299727a9269207f0c" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                              <tr>
                                <td style="width: 22.5pt;"><br>
                                </td>
                                <td style="width: 22.5pt; vertical-align: top; align: right;">&#8226;</td>
                                <td style="width: auto; vertical-align: top;">
                                  <div>indemnification for proceedings involving a final judgment that the director&#8217;s or officer&#8217;s conduct was in bad faith, knowingly fraudulent or deliberately dishonest or constituted willful misconduct or a breach of his
                                    or her duty of loyalty, but only to the extent of such specific determination;</div>
                                </td>
                              </tr>

                          </table>
                        </div>
                      </div>
                      <div style="background-color: #FFFFFF;">
                        <div style="text-indent: -22.5pt; margin-left: 45pt;">&#160;</div>
                      </div>
                      <div>
                        <div>
                          <table id="z53a5e5e42c764e1b8b1513b2561498e3" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                              <tr>
                                <td style="width: 22.5pt;"><br>
                                </td>
                                <td style="width: 22.5pt; vertical-align: top; align: right;">&#8226;</td>
                                <td style="width: auto; vertical-align: top;">
                                  <div>indemnification for proceedings or claims brought by an officer or director against the Registrant or any of the Registrant&#8217;s directors, officers, employees or agents, except for claims to establish a right of
                                    indemnification or proceedings or claims approved by the Registrant&#8217;s board of directors or required by law;</div>
                                </td>
                              </tr>

                          </table>
                        </div>
                      </div>
                      <div style="background-color: #FFFFFF;">
                        <div style="text-indent: -22.5pt; margin-left: 45pt;">&#160;</div>
                      </div>
                      <div>
                        <div>
                          <table id="zac74ad6cde2142c8ac075aeee0a50e49" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                              <tr>
                                <td style="width: 22.5pt;"><br>
                                </td>
                                <td style="width: 22.5pt; vertical-align: top; align: right;">&#8226;</td>
                                <td style="width: auto; vertical-align: top;">
                                  <div>indemnification for settlements the director or officer enters into without the Registrant&#8217;s consent; or</div>
                                </td>
                              </tr>

                          </table>
                          <div> <br>
                          </div>
                          <div>
                            <div>
                              <div>
                                <table id="z9ba4c71142f348fe8c6eb973c5106539" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                                    <tr>
                                      <td style="width: 22.5pt;"><br>
                                      </td>
                                      <td style="width: 22.5pt; vertical-align: top; align: right;">&#8226;</td>
                                      <td style="width: auto; vertical-align: top;">
                                        <div>indemnification in violation of any undertaking required by the Securities Act, or in any registration statement filed by the Registrant.</div>
                                      </td>
                                    </tr>

                                </table>
                              </div>
                            </div>
                          </div>
                        </div>
                      </div>
                    </div>
                    <br>
                    <div>
                      <div>
                        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                          <div id="DSPFPageBreak" style="page-break-after: always;">
                            <hr style="margin: 4px 0px; width: 100%; border-width: 0px; height: 2px; color: rgb(0, 0, 0); background-color: rgb(0, 0, 0); clear: both;" noshade="noshade"></div>
                        </div>
                      </div>
                    </div>
                    <div style="font-style: normal; font-weight: normal;">The indemnification agreements also set forth certain procedures that will apply in the event of a claim for indemnification thereunder, including the Company&#8217;s agreement to advance
                      certain expenses.</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">&#160;</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">At present, there is no pending litigation or proceeding involving any of the Registrant<font style="color: rgb(0, 0, 0);">&#8217;</font>s directors or executive officers as to which
                      indemnification is required or permitted, and the Registrant is not aware of any threatened litigation or proceeding that may result in a claim for indemnification.</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">&#160;</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">The Registrant has an insurance policy in place that covers its officers and directors with respect to certain liabilities, including liabilities arising under the Securities Act, or
                      otherwise.</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div><font style="color: rgb(0, 0, 0); font-style: normal; font-weight: normal;"> </font><font style="font-style: normal;"><br>
                      </font> </div>
                    <font style="font-style: normal;"> </font>
                    <div>
                      <div>
                        <table id="z31afa16e1f2a41bab1b38c32317d0fde" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                            <tr>
                              <td style="width: 54pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">ITEM 7.</td>
                              <td style="width: auto; vertical-align: top;">
                                <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">EXEMPTION FROM REGISTRATION CLAIMED.</div>
                              </td>
                            </tr>

                        </table>
                      </div>
                    </div>
                    <font style="font-style: normal;"> </font>
                    <div style="font-style: normal;">&#160;</div>
                    <font style="font-style: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">Not applicable.</div>
                    <div style="font-style: normal; font-weight: normal;"> <br>
                    </div>
                    <font style="font-style: normal;"> </font>
                    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                      <div id="DSPFPageBreak" style="page-break-after: always;">
                        <hr style="margin-top: 4px; margin-bottom: 4px; width: 100%; border-width: 0px; height: 2px; color: rgb(0, 0, 0); background-color: rgb(0, 0, 0); clear: both;" noshade="noshade"></div>
                    </div>
                    <div>
                      <div>
                        <table id="z453c1e2b8a6448c6ab7dd729c0a5418e" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                            <tr>
                              <td style="width: 54pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">ITEM 8.</td>
                              <td style="width: auto; vertical-align: top;">
                                <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">EXHIBITS.</div>
                              </td>
                            </tr>

                        </table>
                      </div>
                    </div>
                    <font style="font-style: normal;"> </font>
                    <div><font style="color: rgb(0, 0, 0); font-style: normal;"> </font><font style="font-style: normal;"><br>
                      </font> </div>
                    <font style="font-style: normal;"> </font>
                    <table id="z16ead1c7ce284737986d1259885a8c34" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; color: rgb(0, 0, 0);" border="0" cellpadding="0" cellspacing="0">

                        <tr>
                          <td style="width: 10%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
                            <div style="font-weight: bold; text-align: center;">Exhibit</div>
                            <font style="font-weight: bold;"> </font>
                            <div><font style="font-weight: bold;"> </font>
                              <div style="font-weight: bold; text-align: center;">Number</div>
                            </div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; padding-bottom: 2px;">&#160;</td>
                          <td style="width: 89%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
                            <div>
                              <div style="font-weight: bold; text-align: center;">Description</div>
                            </div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119013617/nc10003561x1_ex3-1.htm">4.1</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(204, 238, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;">Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K (File No. 001-38984), filed with the
                              SEC on July 29, 2019).</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">
                            <div style="font-style: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119013617/nc10003561x1_ex3-2.htm">4.2</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(255, 255, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(255, 255, 255);">
                            <div style="font-style: normal;">Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant&#8217;s Current Report on Form 8-K (File No. 001-38984), filed with the SEC on July 29).</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119012901/nt10000802x4_ex4-1.htm">4.3</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(204, 238, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;">Form of Common Stock Certificate of the Registrant (incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form S-1 (File No. 333-232369), originally filed with
                              the SEC on June 26, 2019, as amended).</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">
                            <div style="font-style: normal;"><a href="nt10003552x1_ex5-1.htm">5.1</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(255, 255, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(255, 255, 255);">
                            <div style="font-style: normal;">Opinion of Cooley LLP.</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;"><a href="nt10003552x1_ex23-1.htm">23.1</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(204, 238, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;">Consent of Independent Registered Public Accounting Firm.</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">
                            <div style="font-style: normal;"><a href="nt10003552x1_ex5-1.htm">23.2</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(255, 255, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(255, 255, 255);">
                            <div style="font-style: normal;">Consent of Cooley LLP. Reference is made to Exhibit 5.1.</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;"><a href="#POA">24.1</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(204, 238, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;">Power of Attorney. Reference is made to the signature page hereto.</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">
                            <div style="font-style: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119011686/nt10000802x2_ex10-2.htm">99.1</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(255, 255, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(255, 255, 255);">
                            <div style="font-style: normal;">Castle Biosciences, Inc. 2008 Stock Plan&#160; (incorporated by reference to Exhibit 10.2 to the Registrant&#8217;s Registration Statement on Form S-1 (File No. 333-232369), originally filed with the SEC on
                              June 26, 2019, as amended).</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119011686/nt10000802x2_ex10-4.htm">99.2</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(204, 238, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;">Castle Biosciences, Inc. 2018 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 10.4 to the Registrant&#8217;s Registration Statement on Form S-1 (File No. 333-232369), originally
                              filed with the SEC on June 26, 2019, as amended).</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(255, 255, 255);">
                            <div style="font-style: normal;"><a href="nt10003552x1_ex99-3.htm">99.3</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(255, 255, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(255, 255, 255);">
                            <div style="font-style: normal;">Castle Biosciences, Inc. 2019 Equity Incentive Plan.</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;"><a href="http://www.sec.gov/Archives/edgar/data/1447362/000114036119012901/nt10000802x4_ex10-8.htm">99.4</a></div>
                          </td>
                          <td style="width: 1%; vertical-align: bottom; font-style: normal; background-color: rgb(204, 238, 255);">&#160;</td>
                          <td style="width: 89%; vertical-align: top; background-color: rgb(204, 238, 255);">
                            <div style="font-style: normal;">Castle Biosciences, Inc. 2019 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.8 to the Registrant&#8217;s Registration Statement on Form S-1 (File No. 333-232369), originally
                              filed with the SEC on June 26, 2019, as amended).</div>
                          </td>
                        </tr>

                    </table>
                    <font style="font-style: normal;"> </font>
                    <div><font style="font-style: normal;"><br>
                      </font> </div>
                    <font style="font-style: normal;"> </font>
                    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                      <div id="DSPFPageBreak" style="page-break-after: always;">
                        <hr style="margin-top: 4px; margin-bottom: 4px; width: 100%; border-width: 0px; height: 2px; color: rgb(0, 0, 0); background-color: rgb(0, 0, 0); clear: both;" noshade="noshade"></div>
                    </div>
                    <font style="font-style: normal;"> </font>
                    <div>
                      <div>
                        <table style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z37713684217c4463927000c8be364147" class="DSPFListTable" cellpadding="0" cellspacing="0">

                            <tr style="vertical-align: top;">
                              <td style="vertical-align: top; width: 54pt;">
                                <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">ITEM 9.</div>
                              </td>
                              <td style="align: left; vertical-align: top; width: auto;">
                                <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;">UNDERTAKINGS.</div>
                              </td>
                            </tr>

                        </table>
                      </div>
                    </div>
                    <br>
                    <div>
                      <div> </div>
                    </div>
                    <font style="font-style: normal;"> </font><font style="font-style: normal;"> </font>
                    <div>
                      <div>
                        <div>
                          <div>
                            <div>
                              <table id="z2ac6b815936e4e8694a8e82b3ee43380" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                                  <tr>
                                    <td style="width: 18pt; vertical-align: top;">(a)</td>
                                    <td style="vertical-align: top;">
                                      <div>The undersigned Registrant hereby undertakes:</div>
                                    </td>
                                  </tr>

                              </table>
                            </div>
                          </div>
                          <div>
                            <div>
                              <div> <br>
                              </div>
                              <div>
                                <div>
                                  <div>
                                    <table id="ze627ece356a64ef0b923646d43184c62" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                                        <tr>
                                          <td style="width: 18pt;"><br>
                                          </td>
                                          <td style="width: 18pt; vertical-align: top; align: right;">(1)</td>
                                          <td style="width: auto; vertical-align: top;">
                                            <div>To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</div>
                                          </td>
                                        </tr>

                                    </table>
                                  </div>
                                </div>
                                <div style="color: #000000; font-size: 8pt;">&#160;</div>
                                <div>
                                  <div>
                                    <table id="z89237f98c147483996fcb4fc5d1cc217" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                                        <tr>
                                          <td style="width: 36pt;"><br>
                                          </td>
                                          <td style="width: 27pt; vertical-align: top;">(i)</td>
                                          <td style="width: auto; vertical-align: top;">
                                            <div>To include any prospectus required by Section 10(a)(3) of the Securities Act;</div>
                                          </td>
                                        </tr>

                                    </table>
                                  </div>
                                </div>
                                <div style="color: #000000; font-size: 8pt;">&#160;</div>
                                <div>
                                  <div>
                                    <table id="z51bbb81b5c1b4d689d8e0c1e2be82800" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                                        <tr>
                                          <td style="width: 36pt;"><br>
                                          </td>
                                          <td style="width: 27pt; vertical-align: top;">(ii)</td>
                                          <td style="width: auto; vertical-align: top;">
                                            <div>To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate,
                                              represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
                                              securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the SEC
                                              pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the <font style="color: #000000;">&#8220;</font>Calculation







                                              of Registration Fee<font style="color: #000000;">&#8221;</font> table in the effective Registration Statement;</div>
                                          </td>
                                        </tr>

                                    </table>
                                  </div>
                                </div>
                              </div>
                              <div> <br>
                              </div>
                              <div>
                                <div>
                                  <div>
                                    <table id="z4a2a68e5e03949ea8c0de13620e4202f" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                                        <tr>
                                          <td style="width: 36pt;"><br>
                                          </td>
                                          <td style="width: 27pt; vertical-align: top;">(iii)</td>
                                          <td style="width: auto; vertical-align: top;">
                                            <div>To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement;</div>
                                          </td>
                                        </tr>

                                    </table>
                                  </div>
                                </div>
                              </div>
                              <div> <br>
                              </div>
                            </div>
                          </div>
                          <div>
                            <div> </div>
                          </div>
                          <div>
                            <div> </div>
                          </div>
                          <div>
                            <div> </div>
                          </div>
                          <div style="font-weight: normal; font-style: normal;">Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the Registration Statement is on Form S-8, and the information required to be included in a
                            post-effective amendment by those paragraphs is contained in reports filed with or furnished to the SEC by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the
                            Registration Statement; and</div>
                          <div style="font-weight: normal; font-style: normal;"> <br>
                          </div>
                          <div style="font-weight: normal; font-style: normal;">
                            <div>
                              <div>
                                <table id="zfaeb535bb24846e4aea4c64301484c0e" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                                    <tr>
                                      <td style="width: 18pt;"><br>
                                      </td>
                                      <td style="width: 18pt; vertical-align: top; align: right; color: #000000;">(2)</td>
                                      <td style="width: auto; vertical-align: top;">
                                        <div style="color: #000000;">That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the
                                          securities offered herein, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof.</div>
                                      </td>
                                    </tr>

                                </table>
                              </div>
                            </div>
                            <div style="text-indent: -18pt; margin-left: 36pt; color: #000000; font-size: 8pt;">&#160;</div>
                            <div>
                              <div>
                                <table id="z2f1c5aeb18af40dc9744c6e7da65b99c" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" cellpadding="0" cellspacing="0">

                                    <tr>
                                      <td style="width: 18pt;"><br>
                                      </td>
                                      <td style="width: 18pt; vertical-align: top; align: right; color: #000000;">(3)</td>
                                      <td style="width: auto; vertical-align: top;">
                                        <div style="color: #000000;">To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
                                      </td>
                                    </tr>

                                </table>
                              </div>
                            </div>
                          </div>
                          <div style="font-weight: normal; font-style: normal;"> <br>
                          </div>
                          <div>
                            <div> </div>
                          </div>
                          <div>
                            <div> </div>
                          </div>
                          <div>
                            <div>
                              <table id="z383727780d3740be842565be1518942e" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                                  <tr>
                                    <td style="vertical-align: top; width: 18pt;">(b)</td>
                                    <td style="width: auto; vertical-align: top;">
                                      <div>The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&#8217;s annual report pursuant to Section 13(a) or Section 15(d) of
                                        the Exchange Act (and, where applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be
                                        deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
                                    </td>
                                  </tr>

                              </table>
                            </div>
                          </div>
                          <div>&#160;</div>
                          <div>
                            <div>
                              <table id="z195c30b0ae514d7b9638bd934bc30207" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; color: rgb(0, 0, 0);" cellpadding="0" cellspacing="0">

                                  <tr>
                                    <td style="vertical-align: top; width: 18pt;">(c)</td>
                                    <td style="width: auto; vertical-align: top;">
                                      <div>Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the
                                        Registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for
                                        indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action,
                                        suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been
                                        settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the
                                        final adjudication of such issue.</div>
                                    </td>
                                  </tr>

                              </table>
                            </div>
                          </div>
                          <div>&#160;</div>
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                        </div>
                        <div> </div>
                      </div>
                    </div>
                    <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal; text-align: center;">SIGNATURES</div>
                    <font style="font-style: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">&#160;</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div style="font-style: normal; font-weight: normal;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
                      filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Friendswood, State of Texas, on July 29, 2019.</div>
                    <font style="font-style: normal; font-weight: normal;"> </font>
                    <div><font style="color: rgb(0, 0, 0); font-style: normal; font-weight: normal;"> </font><br>
                      <table id="z6b7f82669bd14b81a44ff54077782448" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; color: rgb(0, 0, 0);" border="0" cellpadding="0" cellspacing="0">

                          <tr>
                            <td style="width: 50%; vertical-align: top;">&#160;</td>
                            <td style="vertical-align: top;" colspan="2">
                              <div style="color: rgb(0, 0, 0); font-weight: bold;">CASTLE BIOSCIENCES, INC.</div>
                            </td>
                          </tr>
                          <tr>
                            <td style="width: 50%; vertical-align: top;">&#160;</td>
                            <td style="width: 5%; vertical-align: middle;">&#160;</td>
                            <td style="vertical-align: middle; width: 45%;">&#160;</td>
                          </tr>
                          <tr>
                            <td style="width: 50%; vertical-align: top;">&#160;</td>
                            <td style="width: 5%; vertical-align: top;">
                              <div>By:</div>
                            </td>
                            <td style="width: 45%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Derek J. Maetzold <br>
                            </td>
                          </tr>
                          <tr>
                            <td style="width: 50%; vertical-align: top;">&#160;</td>
                            <td style="width: 5%; vertical-align: top;">&#160;</td>
                            <td style="width: 45%; vertical-align: bottom;">
                              <div style="font-weight: bold;">Derek J. Maetzold</div>
                            </td>
                          </tr>
                          <tr>
                            <td style="width: 50%; vertical-align: top;">&#160;</td>
                            <td style="width: 5%; vertical-align: top;">&#160;</td>
                            <td style="width: 45%; vertical-align: bottom;">
                              <div style="font-style: italic; font-weight: bold;">President and Chief Executive Officer</div>
                            </td>
                          </tr>

                      </table>
                    </div>
                  </div>
                </div>
                <div style="color: rgb(0, 0, 0); font-style: italic; font-weight: bold;"><font style="font-style: normal; font-weight: normal;"><br>
                  </font><font style="font-style: normal; font-weight: normal;"> </font><font style="font-style: normal; font-weight: normal;"> </font> <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="color: rgb(0, 0, 0); font-weight: bold; font-style: normal;"><a name="POA"><!--Anchor--></a>POWER OF ATTORNEY</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="font-style: normal; font-weight: normal;">&#160;</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Derek J. Maetzold and Frank Stokes, and each of them, as his or
                    her true and lawful attorneys-in-fact and agents, each with the full power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement
                    (including post-effective amendments), and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of
                    them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying
                    and confirming all that said attorneys-in-fact and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="font-style: normal; font-weight: normal;">&#160;</div>
                  <font style="font-style: normal; font-weight: normal;"> </font>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and
                    on the dates indicated.</div>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;"> <br>
                  </div>
                  <div style="text-align: justify; font-style: normal; font-weight: normal;"> </div>
                  <font style="font-style: normal;"> </font><font style="font-style: normal;"> </font>
                  <div style="font-style: normal; text-align: left;">
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                        <tr>
                          <td style="width: 39%; border-bottom: 2px solid rgb(0, 0, 0);">
                            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Signature</div>
                          </td>
                          <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
                          <td style="width: 39%; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">Title</td>
                          <td colspan="1" style="width: 1%; font-weight: bold; text-align: center; padding-bottom: 2px;">&#160;</td>
                          <td style="width: 20%; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">Date</td>
                        </tr>
                        <tr>
                          <td style="width: 39%;" rowspan="1">&#160;</td>
                          <td colspan="1" style="width: 1%;" rowspan="1">&#160;</td>
                          <td style="width: 39%;"><br>
                          </td>
                          <td colspan="1" rowspan="2" style="width: 1%; padding-bottom: 2px;">&#160;</td>
                          <td rowspan="2" style="width: 20%; text-align: right; vertical-align: top; padding-bottom: 2px;"><br>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Derek J. Maetzold<br>
                          </td>
                          <td colspan="1" style="width: 1%; text-align: center; padding-bottom: 2px;">&#160;</td>
                          <td style="width: 39%; text-align: center;">President, Chief Executive Officer and</td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; vertical-align: middle;" rowspan="1">Derek J. Maetzold</td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="2">&#160;</td>
                          <td rowspan="2" style="width: 39%;">
                            <div style="text-align: center;">Member of the Board of Directors</div>
                            <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic;">(Principal Executive Officer)</div>
                          </td>
                          <td colspan="1" rowspan="2" style="width: 1%;">&#160;</td>
                          <td rowspan="2" style="width: 20%; text-align: right; vertical-align: top;">
                            <div>July 29, 2019</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; vertical-align: middle;">&#160;</td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; vertical-align: middle;" rowspan="1">&#160;</td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="1">&#160;</td>
                          <td rowspan="1" style="width: 39%;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%;">&#160;</td>
                          <td rowspan="1" style="width: 20%; text-align: right; vertical-align: top;">&#160;</td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="1">/s/&#160; Frank Stokes <br>
                          </td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="1">&#160;</td>
                          <td rowspan="2" style="width: 39%;">
                            <div style="text-align: center;">Chief Financial Officer</div>
                            <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic;">(Principal Financial and Accounting Officer)</div>
                          </td>
                          <td colspan="1" rowspan="2" style="width: 1%;">&#160;</td>
                          <td rowspan="2" style="width: 20%; text-align: right; vertical-align: top;">
                            <div>July 29, 2019</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center;">&#160;Frank Stokes</td>
                          <td colspan="1" style="width: 1%; text-align: center;">&#160;</td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center;" rowspan="1">&#160;</td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="1">&#160;</td>
                          <td rowspan="1" style="width: 39%;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%;">&#160;</td>
                          <td rowspan="1" style="width: 20%;">&#160;</td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center;" rowspan="1">/s/&#160; Daniel M. Bradbury <br>
                          </td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="1">&#160;</td>
                          <td style="width: 39%; text-align: center; vertical-align: top;" rowspan="2">Chairman of the Board of Directors</td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="2">&#160;</td>
                          <td style="width: 20%; text-align: right; vertical-align: top;" rowspan="2">
                            <div>July 29, 2019</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; border-top: 2px solid rgb(0, 0, 0);">&#160;Daniel M. Bradbury</td>
                          <td colspan="1" style="width: 1%; text-align: center;">&#160;</td>
                        </tr>
                        <tr>
                          <td rowspan="1" style="width: 39%; text-align: center;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%; text-align: center;">&#160;</td>
                          <td style="width: 39%; text-align: center;" rowspan="1">&#160;</td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="1">&#160;</td>
                          <td style="width: 20%;" rowspan="1">&#160;</td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="1">/s/ Bonnie H. Anderson <br>
                          </td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="1">&#160;</td>
                          <td rowspan="2" style="width: 39%; text-align: center; vertical-align: top;">Member of the Board of Directors</td>
                          <td colspan="1" rowspan="2" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="2" style="width: 20%; text-align: right; vertical-align: top;">
                            <div>July 29, 2019</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center;">&#160;Bonnie H. Anderson</td>
                          <td colspan="1" style="width: 1%; text-align: center;">&#160;</td>
                        </tr>
                        <tr>
                          <td rowspan="1" style="width: 39%; text-align: center;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="1" style="width: 39%; text-align: center;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="1" style="width: 20%;">&#160;</td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="1">/s/&#160; Mara Aspinall <br>
                          </td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="1">&#160;</td>
                          <td rowspan="2" style="width: 39%; text-align: center; vertical-align: top;">Member of the Board of Directors</td>
                          <td colspan="1" rowspan="2" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="2" style="width: 20%; text-align: right; vertical-align: top;">
                            <div>July 29, 2019</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center;">&#160;Mara Aspinall</td>
                          <td colspan="1" style="width: 1%; text-align: center;">&#160;</td>
                        </tr>
                        <tr>
                          <td rowspan="1" style="width: 39%; text-align: center;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="1" style="width: 39%; text-align: center;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="1" style="width: 20%;">&#160;</td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="1">/s/&#160; G. Bradley Cole <br>
                          </td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="1">&#160;</td>
                          <td rowspan="2" style="width: 39%; text-align: center; vertical-align: top;">Member of the Board of Directors</td>
                          <td colspan="1" rowspan="2" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="2" style="width: 20%; text-align: right; vertical-align: top;">
                            <div>July 29, 2019</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center;">&#160;G. Bradley Cole</td>
                          <td colspan="1" style="width: 1%; text-align: center;">&#160;</td>
                        </tr>
                        <tr>
                          <td rowspan="1" style="width: 39%; text-align: center;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="1" style="width: 39%; text-align: center;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="1" style="width: 20%;">&#160;</td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="1">&#160;/s/&#160; Joseph C. Cook III<br>
                          </td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="1">&#160;</td>
                          <td rowspan="2" style="width: 39%; text-align: center; vertical-align: top;">Member of the Board of Directors</td>
                          <td colspan="1" rowspan="2" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="2" style="width: 20%; text-align: right; vertical-align: top;">
                            <div>July 29, 2019</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center;">&#160;Joseph C. Cook III</td>
                          <td colspan="1" style="width: 1%; text-align: center;">&#160;</td>
                        </tr>
                        <tr>
                          <td rowspan="1" style="width: 39%; text-align: center;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="1" style="width: 39%; text-align: center;">&#160;</td>
                          <td colspan="1" rowspan="1" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="1" style="width: 20%;">&#160;</td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="1">/s/&#160; David Kabakoff, Ph.D. <br>
                          </td>
                          <td colspan="1" style="width: 1%; text-align: center;" rowspan="1">&#160;</td>
                          <td rowspan="2" style="width: 39%; text-align: center; vertical-align: top;">Member of the Board of Directors</td>
                          <td colspan="1" rowspan="2" style="width: 1%; text-align: center;">&#160;</td>
                          <td rowspan="2" style="width: 20%; text-align: right; vertical-align: top;">
                            <div>July 29, 2019</div>
                          </td>
                        </tr>
                        <tr>
                          <td style="width: 39%; text-align: center;">&#160;David Kabakoff, Ph.D.</td>
                          <td colspan="1" style="width: 1%; text-align: center;">&#160;</td>
                        </tr>

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{"company-data": {"conformed-name": "CASTLE BIOSCIENCES INC", "cik": "0001447362", "assigned-sic": "8071", "irs-number": "770701744", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-232884", "film-number": "19982542"}, "business-address": {"street1": "820 S FRIENDSWOOD DRIVE", "street2": "SUITE 201", "city": "FRIENDSWOOD", "state": "TX", "zip": "77546", "phone": "866-788-9007"}, "mail-address": {"street1": "820 S FRIENDSWOOD DRIVE", "street2": "SUITE 201", "city": "FRIENDSWOOD", "state": "TX", "zip": "77546"}}
As filed with the Securities and Exchange Commission on July 29, 2019
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Castle Biosciences, Inc.
(Exact name of registrant as specified in its charter)
Delaware
77-0701774
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
820 S. Friendswood Drive, Suite 201
Friendswood, Texas
77546
(Address of Principal Executive Offices)
(Zip Code)
2008 Stock Plan
2018 Equity Incentive Plan
2019 Equity Incentive Plan
2019 Employee Stock Purchase Plan
(Full titles of the plans)
Derek Maetzold
President and Chief Executive Officer
Castle Biosciences, Inc.
820 S. Friendswood Drive, Suite 201
Friendswood, Texas 77546
(866) 788-9007
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
Thomas A. Coll, Esq.
Karen E. Anderson, Esq.
Cooley LLP
4401 Eastgate Mall
San Diego, California 92121
(858) 550-6000
I
ndicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company,
                      or an emerging growth company. See the definitions of
"
large accelerated filer,
"
"
accelerated filer,
"
"
smaller reporting company,
"
and
"
emerging growth company
"
in Rule 12b-2 of the Exchange Act.
Large Accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company ☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised
                    financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
CALCULATION OF REGISTRATION FEE
Title of securities
to be registered
Amount
to be
registered (1)
Proposed
maximum
offering price
per share
Proposed
maximum
aggregate
offering price
Amount of
registration fee
2008 Stock Plan
Common Stock, $0.001 par value per share
853,202 shares
(2)
$
2.17
(3)
$
1,851,448.34
(3)
$
224.40
2018 Equity Incentive Plan
Common Stock, $0.001 par value per share
646,526 shares
(4)
$
3.23
(5)
$
2,088,278.98
(5)
$
253.10
2019 Equity Incentive Plan
Common Stock, $0.001 par value per share
3,534,654 shares
(6)
$
19.55
(7)
$
69,102,485.70
(7)
$
8,375.23
2019 Employee Stock Purchase Plan
Common Stock, $0.001 par value per share
411,935 shares
(8)
$
19.55
(7)
$
8,053,329.25
(7)
$
976.07
Total:
5,446,317 shares
N/A
$
81,095,542.27
$
9,828.80
Total:
(1)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of Common Stock ("Common Stock") of Castle Biosciences, Inc.
                                (the "Registrant") that become issuable under the Registrant's 2008 Stock Plan (the "2008 Plan"), the Registrant's 2018 Equity Incentive Plan, as amended (the "2018 Plan"), the Registrant's 2019 Equity Incentive Plan (the
                                "2019 Plan"), or the Registrant's 2019 Employee Stock Purchase Plan (the "2019 ESPP") by reason of any stock dividend, stock split, recapitalization or other similar transaction.
(2)
Represents shares of Common Stock reserved for issuance upon the exercise of outstanding stock options granted under the 2008 Plan. No additional stock awards will be granted under the 2008 Plan, and any shares underlying
                                then-outstanding stock awards granted under the 2008 Plan that, on or after July 24, 2019 expire or terminate for any reason prior to exercise or settlement, or are forfeited because of the failure to meet a contingency or
                                condition required to vest such shares, or otherwise return to the Registrant or are reacquired, withheld or not issued to satisfy a tax withholding obligation in connection with an award or to satisfy the purchase price or
                                exercise price of a stock award (such shares, the
"
2008 Plan Returning Shares
"
), will become available for the grant of stock awards under
                                the 2019 Plan.
(3)
Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h)(1) of the Securities Act. The proposed maximum aggregate offering price per share and proposed maximum aggregate
                                offering price for the 853,202 shares of Common Stock reserved for issuance upon the exercise of outstanding stock options granted under the 2008 Plan are calculated using a weighted average exercise price of $2.17 per
                                share.
(4)
Represents shares of Common Stock reserved for issuance upon the exercise of outstanding stock options granted under the 2018 Plan. No additional stock awards will be granted under the 2018 Plan and the shares remaining
                                available for the grant of future stock awards under the 2018 Plan (the "2018 Plan Pool"), plus any shares underlying then-outstanding stock awards granted under the 2018 Plan, that on or after July 24, 2019 expire or
                                terminate for any reason prior to exercise or settlement, or are forfeited because of the failure to meet a contingency or condition required to vest such shares, or otherwise return to the Registrant or are reacquired,
                                withheld or not issued to satisfy a tax withholding obligation in connection with an award or to satisfy the purchase price or exercise price of a stock award (such shares, the
"
2018

                                Plan Returning Shares,
" and together with the 2008 Plan Returning Shares, the "Returning Shares"
), will become available for the grant of stock awards under the 2019 Plan.
(5)
Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h)(1) of the Securities Act. The proposed maximum aggregate offering price per share and proposed maximum aggregate
                                offering price for the 646,526 shares of Common Stock reserved for issuance upon the exercise of outstanding stock options granted under the 2018 Plan are calculated using a weighted average exercise price of $3.23 per
                                share.
(6)
Represents the sum of 1,931,020 new shares, plus 103,906 shares in the 2018 Plan Pool and the Returning Shares. The 2019 Plan provides that an additional number of shares will automatically be added to the shares
                                authorized for issuance under the 2019 Plan on January 1
st
of each calendar year, from January 1, 2020 through January 1, 2029. The number of
                                shares added each year will be equal to the lesser of: (a) 5% of the total number of shares of capital stock of the Registrant outstanding on December 31 of the preceding calendar year; or (b) such lesser number of shares of
                                Common Stock as the Registrant
'
s board of directors (the
"
Board
"
) may designate prior to the
                                applicable January 1
st
.
(7)
This estimate is made pursuant to Rule 457(h)(1) and Rule 457 (c) of the Securities Act solely for purposes of calculating the registration fee, and is based on the average of the high and low prices of the Common Stock
                                as reported on the Nasdaq Global Market for July 25, 2019.
(8)
Represents 411,935 shares of Common Stock reserved for future grant under the 2019 ESPP. The 2019 ESPP provides that an additional number of shares will automatically be added to the shares authorized for issuance under
                                the 2019 ESPP on January 1
st
of each calendar year, from January 1, 2020 through January 1, 2029. The number of shares of Common Stock added
                                each year will be equal to the lesser of: (a) 1% of the total number of shares of capital stock outstanding on December 31 of the preceding calendar year; (b) 411,935 shares; or (c) such lesser number of shares of Common
                                Stock as the Board may designate prior to the applicable January 1
st
.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
ITEM 1.
PLAN INFORMATION.
Not required to be filed with this Registration Statement.
ITEM 2.
REGISTRANT INFORMATION AND EMPLOYEE PLAN ANNUAL INFORMATION.
Not required to be filed with this Registration Statement.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
ITEM 3.
INCORPORATION OF DOCUMENTS BY REFERENCE.
The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed by the Registrant with the Securities and
                    Exchange Commission ("SEC"):
(a)
The Registrant
'
s
prospectus
dated July 24, 2019 and filed on July 26, 2019 pursuant to Rule 424(b) under the Securities Act, which contains audited
                      financial statements for the Registrant
'
s latest fiscal year for which such statements have been filed, relating to the registration statement on
Form S-1
originally filed on June 26, 2019, as amended (File No. 333-232369), and the registration statement on
Form S-1
filed pursuant to Rule 462(b) of the Securities Act filed on July 24, 2019 (File No. 333-232796).
(b)
The Registrant's
                      Current Report on
Form 8-K
, filed with the SEC on July 29, 2019.
(c)
The description of the Registrant
'
s Common Stock contained in the Registrant
'
s registration statement on
Form
                        8-A
filed on July 15, 2019 (File No. 001-38984) under the Securities Exchange Act of 1934, as amended (the
"
Exchange Act
"
), including any
                      amendment or report filed for the purpose of updating such description.
All documents, reports and definitive proxy or information statements filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of
                    this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be
                    incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents; provided, however, that documents, reports and definitive proxy or information statements, or portions
                    thereof, which are furnished and not filed in accordance with the rules of the SEC shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be
                    incorporated herein by reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement herein or in any other subsequently filed document which also is or is deemed to be
                    incorporated by reference herein modifies or supersedes that statement. Any such statement so modified or superseded shall not constitute a part of this Registration Statement, except as so modified or superseded.
ITEM 4.
DESCRIPTION OF SECURITIES.
Not applicable.
ITEM 5.
INTERESTS OF NAMED EXPERTS AND COUNSEL.
Not applicable.
ITEM 6.
INDEMNIFICATION OF DIRECTORS AND OFFICERS.
The Registrant is incorporated under the laws of the State of Delaware. Section 145 of the Delaware General Corporation Law provides that a Delaware corporation
                    may indemnify any persons who were, are, or are threatened to be made, parties to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in
                    the right of such corporation), by reason of the fact that such person is or was an officer, director, employee or agent of such corporation, or is or was serving at the request of such corporation as an officer, director, employee or
                    agent of another corporation or enterprise. The indemnity may include expenses (including attorneys
'
fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by
                    such person in connection with such action, suit or proceeding, provided that such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation
'
s
                    best interests and, with respect to any criminal action or proceeding, had no reasonable cause to believe that his or her conduct was illegal. A Delaware corporation may indemnify any persons who were, are, or are threatened to be made,
                    a party to any threatened, pending or completed action or suit by or in the right of the corporation by reason of the fact that such person is or was a director, officer, employee or agent of such corporation, or is or was serving at
                    the request of such corporation as a director, officer, employee or agent of another corporation or enterprise. The indemnity may include expenses (including attorneys
'
fees) actually and
                    reasonably incurred by such person in connection with the defense or settlement of such action or suit; provided such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation
'
s best interests, except that no indemnification is permitted without judicial approval if the officer or director is adjudged to be liable to the corporation. Where an officer or director is
                    successful on the merits or otherwise in the defense of any action referred to above, the corporation must indemnify him or her against the expenses (including attorneys
'
fees) actually and
                    reasonably incurred.
The Registrant
'
s amended and restated certificate of incorporation and amended and restated bylaws provide for the
                    indemnification of its directors and officers to the fullest extent permitted under the Delaware General Corporation Law.
Section 102(b)(7) of the Delaware General Corporation Law permits a corporation to provide in its certificate of incorporation that a director of the corporation
                    shall not be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duties as a director, except for liability for any:
•
transaction from which the director derives an improper personal benefit;
•
act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;
•
unlawful payment of dividends or redemption of shares; or
•
breach of a director
'
s duty of loyalty to the corporation or its stockholders.
The Registrant
'
s amended and restated certificate of incorporation includes such a provision. Expenses incurred by any officer or director
                      in defending any such action, suit or proceeding in advance of its final disposition shall be paid by the Registrant upon delivery to it of an undertaking, by or on behalf of such director or officer, to repay all amounts so advanced
                      if it shall ultimately be determined that such director or officer is not entitled to be indemnified by the Registrant.
Section 174 of the Delaware General Corporation Law provides, among other things, that a director who willfully or negligently approves of an unlawful payment of dividends or an
                      unlawful stock purchase or redemption may be held liable for such actions. A director who was either absent when the unlawful actions were approved, or dissented at the time, may avoid liability by causing his or her dissent to such
                      actions to be entered in the books containing minutes of the meetings of the board of directors at the time such action occurred or immediately after such absent director receives notice of the unlawful acts.
As permitted by the Delaware General Corporation Law, the Registrant has entered into indemnity agreements with each of its directors and executive officers, that require the
                      Registrant to indemnify such persons against any and all costs and expenses (including attorneys', witness or other professional fees) actually and reasonably incurred by such persons in connection with any action, suit or proceeding
                      (including derivative actions), whether actual or threatened, to which any such person may be made a party by reason of the fact that such person is or was a director or officer or is or was acting or serving as an officer, director,
                      employee or agent of the Registrant or any of its affiliated enterprises. Under these agreements, the Registrant is not required to provide indemnification for certain matters, including:
•
indemnification beyond that permitted by the Delaware General Corporation Law;
•
indemnification for any proceeding with respect to the unlawful payment of remuneration to the director or officer;
•
indemnification for certain proceedings involving a final judgment that the director or officer is required to disgorge profits from the purchase or sale of the Registrant's stock;
•
indemnification for proceedings involving a final judgment that the director's or officer's conduct was in bad faith, knowingly fraudulent or deliberately dishonest or constituted willful misconduct or a breach of his
                                    or her duty of loyalty, but only to the extent of such specific determination;
•
indemnification for proceedings or claims brought by an officer or director against the Registrant or any of the Registrant's directors, officers, employees or agents, except for claims to establish a right of
                                    indemnification or proceedings or claims approved by the Registrant's board of directors or required by law;
•
indemnification for settlements the director or officer enters into without the Registrant's consent; or
•
indemnification in violation of any undertaking required by the Securities Act, or in any registration statement filed by the Registrant.
The indemnification agreements also set forth certain procedures that will apply in the event of a claim for indemnification thereunder, including the Company's agreement to advance
                      certain expenses.
At present, there is no pending litigation or proceeding involving any of the Registrant
'
s directors or executive officers as to which
                      indemnification is required or permitted, and the Registrant is not aware of any threatened litigation or proceeding that may result in a claim for indemnification.
The Registrant has an insurance policy in place that covers its officers and directors with respect to certain liabilities, including liabilities arising under the Securities Act, or
                      otherwise.
ITEM 7.
EXEMPTION FROM REGISTRATION CLAIMED.
Not applicable.
ITEM 8.
EXHIBITS.
Exhibit
Number
Description
4.1
Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-38984), filed with the
                              SEC on July 29, 2019).
4.2
Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K (File No. 001-38984), filed with the SEC on July 29).
4.3
Form of Common Stock Certificate of the Registrant (incorporated by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form S-1 (File No. 333-232369), originally filed with
                              the SEC on June 26, 2019, as amended).
5.1
Opinion of Cooley LLP.
23.1
Consent of Independent Registered Public Accounting Firm.
23.2
Consent of Cooley LLP. Reference is made to Exhibit 5.1.
24.1
Power of Attorney. Reference is made to the signature page hereto.
99.1
Castle Biosciences, Inc. 2008 Stock Plan  (incorporated by reference to Exhibit 10.2 to the Registrant's Registration Statement on Form S-1 (File No. 333-232369), originally filed with the SEC on
                              June 26, 2019, as amended).
99.2
Castle Biosciences, Inc. 2018 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 10.4 to the Registrant's Registration Statement on Form S-1 (File No. 333-232369), originally
                              filed with the SEC on June 26, 2019, as amended).
99.3
Castle Biosciences, Inc. 2019 Equity Incentive Plan.
99.4
Castle Biosciences, Inc. 2019 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.8 to the Registrant's Registration Statement on Form S-1 (File No. 333-232369), originally
                              filed with the SEC on June 26, 2019, as amended).
ITEM 9.
UNDERTAKINGS.
(a)
The undersigned Registrant hereby undertakes:
(1)
To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)
To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate,
                                              represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
                                              securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the SEC
                                              pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the
"
Calculation

                                              of Registration Fee
"
table in the effective Registration Statement;
(iii)
To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement;
Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the Registration Statement is on Form S-8, and the information required to be included in a
                            post-effective amendment by those paragraphs is contained in reports filed with or furnished to the SEC by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the
                            Registration Statement; and
(2)
That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the
                                          securities offered herein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(3)
To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)
The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of
                                        the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be
                                        deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the
                                        Registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for
                                        indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action,
                                        suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been
                                        settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the
                                        final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
                      filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Friendswood, State of Texas, on July 29, 2019.
CASTLE BIOSCIENCES, INC.
By:
/s/ Derek J. Maetzold
Derek J. Maetzold
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Derek J. Maetzold and Frank Stokes, and each of them, as his or
                    her true and lawful attorneys-in-fact and agents, each with the full power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement
                    (including post-effective amendments), and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of
                    them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying
                    and confirming all that said attorneys-in-fact and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and
                    on the dates indicated.
Signature
Title
Date
/s/ Derek J. Maetzold
President, Chief Executive Officer and
Derek J. Maetzold
Member of the Board of Directors
(Principal Executive Officer)
July 29, 2019
/s/  Frank Stokes
Chief Financial Officer
(Principal Financial and Accounting Officer)
July 29, 2019
Frank Stokes
/s/  Daniel M. Bradbury
Chairman of the Board of Directors
July 29, 2019
Daniel M. Bradbury
/s/ Bonnie H. Anderson
Member of the Board of Directors
July 29, 2019
Bonnie H. Anderson
/s/  Mara Aspinall
Member of the Board of Directors
July 29, 2019
Mara Aspinall
/s/  G. Bradley Cole
Member of the Board of Directors
July 29, 2019
G. Bradley Cole
/s/  Joseph C. Cook III
Member of the Board of Directors
July 29, 2019
Joseph C. Cook III
/s/  David Kabakoff, Ph.D.
Member of the Board of Directors
July 29, 2019
David Kabakoff, Ph.D.