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      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">As filed with the Securities and Exchange Commission on March 10, 2020</div>
      <div style="text-align: right; font-family: 'Times New Roman', Times, serif; font-weight: bold;">No. 333-______</div>
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        <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-weight: bold;"><font style="font-size: 14pt;">UNITED STATES</font><br>
          <font style="font-size: 14pt;">SECURITIES AND EXCHANGE COMMISSION</font><br>
          Washington, D.C. 20549</div>
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        <hr style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000;" align="center" noshade="noshade"><font style="font-size: 18pt;">FORM S-8</font><br>
        REGISTRATION STATEMENT<br>
        <font style="font-style: italic;">UNDER</font><br>
        <font style="font-style: italic;">THE SECURITIES ACT OF 1933</font>
        <hr style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000;" align="center" noshade="noshade"></div>
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      <div style="text-align: center; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 24pt; font-weight: bold;">Bristol-Myers Squibb Company</font><br>
        (Exact name of registrant as specified in its charter)</div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif;"> <br>
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      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z62dd88e73210415d884bee62eac5d403" border="0" cellpadding="0" cellspacing="0">

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              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Delaware</div>
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            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">22-0790350</div>
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              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">(State or other Jurisdiction of Incorporation or Organization)</div>
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            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">(I.R.S. Employer Identification No.)</div>
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      <div style="text-align: center; font-family: 'Times New Roman', Times, serif;"><font style="font-weight: bold;">430 East 29th Street, 14th Floor, New York, New York 10016</font><br>
        <font style="font-weight: bold;">(212) 546-4000</font><br>
        (Address including Zip Code of Principal Executive Offices)<br>
        <br>
        <font style="font-weight: bold;">Bristol-Myers Squibb Company 2017 Stock Incentive Plan</font><br>
        <font style="font-weight: bold;">Bristol-Myers Squibb Company 2014 Equity Incentive Plan</font><br>
        <br>
        (Full title of the plan)<br>
        <br>
        <font style="font-weight: bold;">Sandra Leung, Esq.</font><br>
        <font style="font-weight: bold;">Bristol-Myers Squibb Company</font><br>
        <font style="font-weight: bold;">430 East 29th Street, 14th Floor</font><br>
        <font style="font-weight: bold;">New York, New York 10016</font><br>
        <font style="font-weight: bold;">(212) 546-3309</font><br>
        (Name, address and telephone number, including area code, of agent for service)</div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-style: italic;"> <br>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-style: italic;">With a copy to:</div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-style: italic;"> <br>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Sophia Hudson, P.C.<br>
        Kirkland &amp; Ellis LLP<br>
        601 Lexington Avenue<br>
        New York, New York 10022<br>
        (212) 446-4800</div>
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      <div style="font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="font-family: 'Times New Roman', Times, serif;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See
        definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;small reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="zf11b7ec22a984f46a092af21e7907c5a" border="0" cellpadding="0" cellspacing="0">

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              <div style="font-family: 'Times New Roman', Times, serif;">Large accelerated filer</div>
            </td>
            <td style="width: 5%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">&#9746;</div>
            </td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Accelerated filer</div>
            </td>
            <td style="width: 5%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">&#9744;</div>
            </td>
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              <div style="font-family: 'Times New Roman', Times, serif;">Non-accelerated filer</div>
            </td>
            <td style="width: 5%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">&#9744;</div>
            </td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Smaller reporting company</div>
            </td>
            <td style="width: 5%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">&#9744;</div>
            </td>
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            <td style="width: 45%; vertical-align: top;">&#160;</td>
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              <div style="font-family: 'Times New Roman', Times, serif;"><br>
              </div>
            </td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Emerging growth company</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#9744;</td>
          </tr>

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      </div>
      <div style="font-family: 'Times New Roman', Times, serif;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
        standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.&#160; &#160;&#160; &#9744;</div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
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            <td rowspan="1" style="border-bottom: medium double; vertical-align: bottom; width: 15%;">&#160;</td>
            <td rowspan="1" style="border-bottom: medium double; vertical-align: bottom; width: 15%;">&#160;</td>
            <td rowspan="1" style="border-bottom: medium double; vertical-align: bottom; width: 15%;">&#160;</td>
            <td rowspan="1" style="border-bottom: medium double; vertical-align: bottom; width: 15px;">&#160;</td>
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              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Title of securities to be registered</div>
            </td>
            <td style="border-bottom: 1px solid; border-right: 1px solid; vertical-align: bottom; width: 15%;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Amount to be</div>
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">registered<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup> </div>
            </td>
            <td style="border-bottom: 1px solid; border-right: 1px solid; vertical-align: bottom; width: 15%;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Proposed maximum</div>
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">
                <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><font style="font-weight: bold;">offering price per unit</font><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
              </div>
            </td>
            <td style="border-bottom: 1px solid; border-right: 1px solid; vertical-align: bottom; width: 15%;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Proposed maximum</div>
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">
                <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><font style="font-weight: bold;">aggregate offering price</font><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
              </div>
            </td>
            <td style="border-bottom: 1px solid; border-right: 1px solid; vertical-align: bottom; width: 15px;">
              <div style="font-weight: bold; text-align: center;">Amount of</div>
              <div style="text-align: center;"><font style="font-weight: bold;">registration fee<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></font> </div>
            </td>
          </tr>
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            <td style="border-bottom: medium double; border-left: 1px solid; border-right: 1px solid; vertical-align: top; width: 40%;">
              <div style="font-family: 'Times New Roman', Times, serif;">Bristol-Myers Squibb Contingent Value Rights (CVRs)</div>
            </td>
            <td style="border-bottom: medium double; border-right: 1px solid; vertical-align: top; width: 15%;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">12,241,001</div>
            </td>
            <td style="border-bottom: medium double; border-right: 1px solid; vertical-align: top; width: 15%;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">$3.41</div>
            </td>
            <td style="border-bottom: medium double; border-right: 1px solid; vertical-align: top; width: 15%;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">$41,741,813.41</div>
            </td>
            <td style="border-bottom: medium double; border-right: 1px solid; vertical-align: top; width: 15px;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">$5,419</div>
            </td>
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      <div style="text-align: justify;">
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                <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(1)</td>
                <td style="width: auto; vertical-align: top; text-align: justify;">
                  <div style="font-family: 'Times New Roman', Times, serif; font-size: 8pt;">This Registration Statement on Form S-8 (&#8220;<font style="font-weight: bold;">Registration Statement</font>&#8221;) registers offers and sales of 12,241,001 Bristol-Myers
                    Squibb Contingent Value Rights (&#8220;<font style="font-weight: bold;">CVRs</font>&#8221;) that may be issuable to holders (other than former employees of Celgene Corporation (&#8220;<font style="font-weight: bold;">Celgene</font>&#8221;) at the effective
                    time of the Merger (as defined below)) of certain stock options, restricted stock units, performance stock units and restricted stock awards of the Company, in connection with the merger (&#8220;<font style="font-weight: bold;">Merger</font>&#8221;)







                    of Burgundy Merger Sub, Inc., a wholly-owned subsidiary of Bristol-Myers Squibb Company (&#8220;<font style="font-weight: bold;">Merger Sub</font>&#8221;), with and into Celgene, pursuant to the Agreement and Plan of Merger, dated as of January 2,
                    2019 (&#8220;<font style="font-weight: bold;">Merger Agreement</font>&#8221;), among Bristol-Myers Squibb Company, Merger Sub and Celgene.</div>
                </td>
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      <div style="text-align: justify;">
        <div>
          <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2c1a4e25ce7d4a48af1342796f9aabbf" cellpadding="0" cellspacing="0">

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                <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(2)</td>
                <td style="width: auto; vertical-align: top; text-align: justify;">
                  <div style="font-family: 'Times New Roman', Times, serif; font-size: 8pt;">Estimated solely for the purpose of computing the registration fee pursuant to Rule 457(h) and Rule 457(c) under the Securities Act of 1933 (&#8220;<font style="font-weight: bold;">Securities Act</font>&#8221;), as amended. The price per CVR is based on the average of the high and low prices reported for a CVR on the New York Stock Exchange on March 4, 2020.</div>
                </td>
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      </div>
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        <div style="text-align: justify;">
          <div>
            <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zeed7a396916a4188b6e1a1ed199be39d" cellpadding="0" cellspacing="0">

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                  <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(3)</td>
                  <td style="width: auto; vertical-align: top; text-align: justify;">
                    <div style="font-family: 'Times New Roman', Times, serif; font-size: 8pt;">Determined in accordance with Section 6(b) of the Securities Act at a rate equal to $129.80 per $1,000,000 of the proposed maximum aggregate offering price.</div>
                  </td>
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      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">REGISTRATION OF ADDITIONAL SECURITIES PURSUANT TO GENERAL INSTRUCTION E</div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">Pursuant to General Instruction E of Form S-8, Bristol-Myers Squibb Company (the &#8220;<font style="font-weight: bold;">Registrant</font>&#8221; or the &#8220;<font style="font-weight: bold;">Company</font>&#8221;) is filing this Registration Statement to register 12,241,001 additional CVRs that may be issuable to holders (other than former employees of Celgene at the effective time of the Merger) of certain stock
        options, restricted stock units, performance stock units and restricted stock awards of the Company, pursuant to and subject to the terms of (a) the Merger Agreement; (b) the Bristol-Myers Squibb Company 2017 Stock Incentive Plan (F/K/A Celgene
        Corporation 2017 Stock Incentive Plan) and the Bristol-Myers Squibb Company 2014 Equity Incentive Plan (F/K/A Celgene Corporation 2014 Equity Incentive Plan), each of which was formerly a Celgene equity incentive plan and was assumed by the Company
        in connection with the Merger; and (c) the Contingent Value Rights Agreement, dated November 20, 2019, between the Company and Equiniti Trust Company, as trustee, in favor of each person who from time to time holds one or more CVRs.</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">This Registration Statement hereby incorporates by reference the contents of the Registration Statement on Form S-8 (File No. 333-235254), filed with
        Securities and Exchange Commission (the &#8220;<font style="font-weight: bold;">Commission</font>&#8221;) on November 25, 2019.</div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">PART II<br>
        <br>
        INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
      <div><font style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 3.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Incorporation of Documents by Reference</font></div>
      <div><font style="font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
        </font></div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">The following documents filed with the Commission by the Company pursuant to the Securities Act and the Securities Exchange Act of 1934, as amended
        (the &#8220;<font style="font-weight: bold;">1934 Act</font>&#8221;) are incorporated herein by reference:</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">(a)&#160;The Company&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2019 (filed with the Commission on <a href="http://www.sec.gov/Archives/edgar/data/14272/000001427220000082/bmy-20191231x10xk.htm">February 24, 2020</a>).</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">(b)&#160;The Company&#8217;s Current Reports on Form 8-K filed with the Commission on <a href="http://www.sec.gov/Archives/edgar/data/14272/000114036120002397/form8ka.htm">February 5, 2020</a>, <a href="http://www.sec.gov/Archives/edgar/data/14272/000114036120003922/form8k.htm">February 24, 2020</a> and <a href="http://www.sec.gov/Archives/edgar/data/14272/000114036120005184/nc10009726x1_8k.htm">March 9, 2020</a>.</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">(c)&#160;All future reports filed pursuant to Section 13(a) and 15(d) of the 1934 Act by the Company since the end of the fiscal year covered by the annual
        report referred to in (a) above; provided, however, that the foregoing shall not include the incorporation by reference of any information furnished pursuant to Items 2.02, 7.01 or 9.01 of Form 8-K.</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">(d)&#160;The description of the CVRs, which is contained in the Company&#8217;s Registration Statement on Form 8-A12B (File No. 001-01136) (filed with the
        Commission on <a href="http://www.sec.gov/Archives/edgar/data/14272/000114036119020744/form8a12b.htm">November 18, 2019</a>), as updated by the description of the Company&#8217;s registered securities filed as Exhibit 4ggg to the Company&#8217;s Annual Report
        on Form 10-K for the fiscal year ended December 31, 2019 (filed with the Commission on <a href="http://www.sec.gov/Archives/edgar/data/14272/000001427220000082/bmy-20191231x10xk.htm">February 24, 2020</a>), including any amendments or supplements
        thereto.</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">In addition, all documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing
        of a post-effective amendment to this Registration Statement that indicates that all securities offered have been sold or that deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in the Registration
        Statement and to be a part hereof from the date of the filing of such documents (other than current reports furnished under Items 2.02, 7.01 or 9.01 of Form 8-K). Any statement contained in a document incorporated or deemed to be incorporated by
        reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein (or in any other subsequently filed document which also is incorporated or deemed to be
        incorporated by reference herein) modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</div>
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      <div><font style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Item 8.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Exhibits.</font></div>
      <div><font style="font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
        </font></div>
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              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Exhibit</div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">&#160;</td>
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          <tr>
            <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Number</div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 94%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Description</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="http://www.sec.gov/Archives/edgar/data/14272/000119312505156446/dex3a.htm">4.1</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Amended and Restated Certificate of Incorporation of Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 3a to Bristol Myers-Squibb Company&#8217;s Quarterly Report on
                Form 10-Q for the quarterly period ended June 30, 2005).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="http://www.sec.gov/Archives/edgar/data/14272/000119312511040120/dex3b.htm">4.1A</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Certificate of Correction to the Amended and Restated Certificate of Incorporation, effective as of December 24, 2009 (incorporated herein by reference to Exhibit 3b to Bristol
                Myers-Squibb Company&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2010).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="http://www.sec.gov/Archives/edgar/data/14272/000119312510114770/dex3a.htm">4.1B</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Certificate of Amendment to the Amended and Restated Certificate of Incorporation, effective as of May 7, 2010 (incorporated herein by reference to Exhibit 3a to Bristol Myers-Squibb
                Company&#8217;s Current Report on Form 8-K filed on May 10, 2010).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="http://www.sec.gov/Archives/edgar/data/14272/000119312510114770/dex3b.htm">4.1C</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Certificate of Amendment to the Amended and Restated Certificate of Incorporation, effective as of May 7, 2010 (incorporated herein by reference to Exhibit 3b to Bristol Myers-Squibb
                Company&#8217;s Current Report on Form 8-K filed on May 10, 2010).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="http://www.sec.gov/Archives/edgar/data/14272/000156761916003171/s001466x1_ex3-1.htm">4.2</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Bylaws of Bristol-Myers Squibb Company, as amended as of November 2, 2016 (incorporated herein by reference to Exhibit 3.1 to Bristol Myers-Squibb Company&#8217;s Current Report on Form 8-K
                filed on November 4, 2016).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="http://www.sec.gov/Archives/edgar/data/14272/000001427220000082/bmy-20191231exhibit4ccc.htm">4.3</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Contingent Value Rights Agreement, between Bristol Myers Squibb Company and Equiniti Trust Company, dated November 20, 2019 (incorporated by reference to Exhibit 4ccc to Bristol
                Myers-Squibb Company&#8217;s Form 10-K dated February 24, 2020 and filed on February 24, 2020).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="nt10009659x1_ex5-1.htm">5.1*</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Opinion of Kirkland &amp; Ellis LLP.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="nt10009659x1_ex23-1.htm">23.1*</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Consent of Deloitte &amp; Touche LLP Independent Registered Public Accounting Firm of Bristol-Myers Squibb Company.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="nt10009659x1_ex23-2.htm">23.2*</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Consent of KPMG LLP, independent registered public accounting firm of Celgene Corporation.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="nt10009659x1_ex5-1.htm">23.3*</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Consent of Kirkland &amp; Ellis LLP (included in Exhibit 5.1).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="#POWEROFATTORNEY">24.1</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Powers of Attorney (included in the signature pages hereof).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="http://www.sec.gov/Archives/edgar/data/14272/000114036119021379/ex99_1.htm">99.1</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Bristol-Myers Squibb Company 2017 Stock Incentive Plan (F/K/A Celgene Corporation 2017 Stock Incentive Plan) (incorporated by reference to Exhibit 99.1 to Bristol Myers-Squibb
                Company&#8217;s Form S-8 filed on November 25, 2019).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;"><a href="http://www.sec.gov/Archives/edgar/data/14272/000114036119021379/ex99_2.htm">99.2</a></div>
            </td>
            <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 94%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Bristol-Myers Squibb Company 2014 Equity Incentive Plan (F/K/A Celgene Corporation 2014 Equity Incentive Plan) (incorporated by reference to Exhibit 99.2 to Bristol Myers-Squibb
                Company&#8217;s Form S-8 filed on November 25, 2019).</div>
            </td>
          </tr>

      </table>
      <div style="font-family: 'Times New Roman', Times, serif;"><font style="font-weight: bold;"> <br>
        </font></div>
      <div style="font-family: 'Times New Roman', Times, serif;"><font style="font-weight: bold;">*</font>Filed herewith</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">2</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">SIGNATURES</div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it
        meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, on the 10th day of March, 2020.</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="zd039906ba0834dd5a8d4ce372450e0f0" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">BRISTOL-MYERS SQUIBB COMPANY</div>
            </td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
            <td rowspan="1" style="width: 5%; vertical-align: top;">&#160;</td>
            <td rowspan="1" style="width: 45%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
              <div style="font-family: 'Times New Roman', Times, serif;">By:</div>
            </td>
            <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">/s/ Sandra Leung</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Sandra Leung</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">Executive Vice President and General Counsel</div>
            </td>
          </tr>

      </table>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">3</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
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      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
      <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">Each person whose signature appears below constitutes and appoints Sandra Leung and Katherine R. Kelly as his or her true and lawful attorneys-in-fact
        and agents, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign the name of each of the undersigned in his or her capacity to any and all amendments
        (including any post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto such said
        attorney-in-fact and agent full power and authority to do and perform each and every act and thing necessary or advisable to be done, as fully to all intents and purposes as the undersigned might or could do in person, and each of the undersigned
        hereby ratifies and confirms that the said attorney-in-fact or agent shall do or cause to be done by virtue hereof.</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;">Pursuant to the requirements of the Securities Act of 1933, this registration statement on Form S-8 has been signed below by the following persons in
        the capacities and on the dates indicated.</div>
      <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z1cf0b038445341ddab512e83ae96af55" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Signature</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 40%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Title</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Date</div>
            </td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 40%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">/s/ Giovanni Caforio</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" rowspan="2" style="width: 40%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-style: italic;">Chief Executive Officer and Director (Principal Executive Officer)</div>
              &#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 30%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">March 10, 2020</div>
            </td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">Giovanni Caforio, M.D.</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 40%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">/s/ David V. Elkins</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 40%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-style: italic;">Chief Financial Officer (Principal Financial Officer)</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 30%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">March 10, 2020</div>
            </td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">David V. Elkins</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 40%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 40%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">/s/ Karen M. Santiago</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td colspan="1" rowspan="2" style="width: 40%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-style: italic;">Senior Vice President and Corporate Controller (Principal Accounting Officer)</div>
              &#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 30%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">March 10, 2020</div>
            </td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">Karen M. Santiago</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 40%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">/s/ Vicki L. Sato, Ph.D.</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 40%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-style: italic;">Lead Independent Director</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 30%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">March 10, 2020</div>
            </td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">Vicki L. Sato, Ph.D.</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
            <td style="width: 40%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 40%; vertical-align: top; text-align: center;">&#160;</td>
            <td colspan="1" style="width: 1%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 30%; vertical-align: top; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">/s/ Peter J. Arduini</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 40%; vertical-align: top; padding-bottom: 2px;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-style: italic;">Director</div>
            </td>
            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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            <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">/s/ Robert Bertolini</div>
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            <td style="width: 40%; vertical-align: top; padding-bottom: 2px;">
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            <td style="width: 40%; vertical-align: top; padding-bottom: 2px;">
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{"company-data": {"conformed-name": "BRISTOL MYERS SQUIBB CO", "cik": "0000014272", "assigned-sic": "2834", "irs-number": "220790350", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-237055", "film-number": "20701930"}, "business-address": {"street1": "430 E. 29TH STREET", "street2": "14 FLOOR", "city": "NEW YORK", "state": "NY", "zip": "10016", "phone": "2125464000"}, "mail-address": {"street1": "430 E. 29TH STREET", "street2": "14 FLOOR", "city": "NEW YORK", "state": "NY", "zip": "10016"}, "former-company": {"former-conformed-name": "BRISTOL MYERS CO", "date-changed": "19891012"}}
As filed with the Securities and Exchange Commission on March 10, 2020
No. 333-______
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Bristol-Myers Squibb Company
(Exact name of registrant as specified in its charter)
Delaware
22-0790350
(State or other Jurisdiction of Incorporation or Organization)
(I.R.S. Employer Identification No.)
430 East 29th Street, 14th Floor, New York, New York 10016
(212) 546-4000
(Address including Zip Code of Principal Executive Offices)
Bristol-Myers Squibb Company 2017 Stock Incentive Plan
Bristol-Myers Squibb Company 2014 Equity Incentive Plan
(Full title of the plan)
Sandra Leung, Esq.
Bristol-Myers Squibb Company
430 East 29th Street, 14th Floor
New York, New York 10016
(212) 546-3309
(Name, address and telephone number, including area code, of agent for service)
With a copy to:
Sophia Hudson, P.C.
Kirkland & Ellis LLP
601 Lexington Avenue
New York, New York 10022
(212) 446-4800
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See
        definitions of "large accelerated filer," "accelerated filer," "small reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☒
Accelerated filer
☐
Non-accelerated filer
☐
Smaller reporting company
☐
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
        standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.     ☐
CALCULATION OF REGISTRATION FEE
Title of securities to be registered
Amount to be
registered
(1)
Proposed maximum
offering price per unit
(2)
Proposed maximum
aggregate offering price
(2)
Amount of
registration fee
(3)
Bristol-Myers Squibb Contingent Value Rights (CVRs)
12,241,001
$3.41
$41,741,813.41
$5,419
(1)
This Registration Statement on Form S-8 ("
Registration Statement
") registers offers and sales of 12,241,001 Bristol-Myers
                    Squibb Contingent Value Rights ("
CVRs
") that may be issuable to holders (other than former employees of Celgene Corporation ("
Celgene
") at the effective
                    time of the Merger (as defined below)) of certain stock options, restricted stock units, performance stock units and restricted stock awards of the Company, in connection with the merger ("
Merger
")

                    of Burgundy Merger Sub, Inc., a wholly-owned subsidiary of Bristol-Myers Squibb Company ("
Merger Sub
"), with and into Celgene, pursuant to the Agreement and Plan of Merger, dated as of January 2,
                    2019 ("
Merger Agreement
"), among Bristol-Myers Squibb Company, Merger Sub and Celgene.
(2)
Estimated solely for the purpose of computing the registration fee pursuant to Rule 457(h) and Rule 457(c) under the Securities Act of 1933 ("
Securities Act
"), as amended. The price per CVR is based on the average of the high and low prices reported for a CVR on the New York Stock Exchange on March 4, 2020.
(3)
Determined in accordance with Section 6(b) of the Securities Act at a rate equal to $129.80 per $1,000,000 of the proposed maximum aggregate offering price.
REGISTRATION OF ADDITIONAL SECURITIES PURSUANT TO GENERAL INSTRUCTION E
Pursuant to General Instruction E of Form S-8, Bristol-Myers Squibb Company (the "
Registrant
" or the "
Company
") is filing this Registration Statement to register 12,241,001 additional CVRs that may be issuable to holders (other than former employees of Celgene at the effective time of the Merger) of certain stock
        options, restricted stock units, performance stock units and restricted stock awards of the Company, pursuant to and subject to the terms of (a) the Merger Agreement; (b) the Bristol-Myers Squibb Company 2017 Stock Incentive Plan (F/K/A Celgene
        Corporation 2017 Stock Incentive Plan) and the Bristol-Myers Squibb Company 2014 Equity Incentive Plan (F/K/A Celgene Corporation 2014 Equity Incentive Plan), each of which was formerly a Celgene equity incentive plan and was assumed by the Company
        in connection with the Merger; and (c) the Contingent Value Rights Agreement, dated November 20, 2019, between the Company and Equiniti Trust Company, as trustee, in favor of each person who from time to time holds one or more CVRs.
This Registration Statement hereby incorporates by reference the contents of the Registration Statement on Form S-8 (File No. 333-235254), filed with
        Securities and Exchange Commission (the "
Commission
") on November 25, 2019.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference
The following documents filed with the Commission by the Company pursuant to the Securities Act and the Securities Exchange Act of 1934, as amended
        (the "
1934 Act
") are incorporated herein by reference:
(a) The Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2019 (filed with the Commission on
February 24, 2020
).
(b) The Company's Current Reports on Form 8-K filed with the Commission on
February 5, 2020
,
February 24, 2020
and
March 9, 2020
.
(c) All future reports filed pursuant to Section 13(a) and 15(d) of the 1934 Act by the Company since the end of the fiscal year covered by the annual
        report referred to in (a) above; provided, however, that the foregoing shall not include the incorporation by reference of any information furnished pursuant to Items 2.02, 7.01 or 9.01 of Form 8-K.
(d) The description of the CVRs, which is contained in the Company's Registration Statement on Form 8-A12B (File No. 001-01136) (filed with the
        Commission on
November 18, 2019
), as updated by the description of the Company's registered securities filed as Exhibit 4ggg to the Company's Annual Report
        on Form 10-K for the fiscal year ended December 31, 2019 (filed with the Commission on
February 24, 2020
), including any amendments or supplements
        thereto.
In addition, all documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing
        of a post-effective amendment to this Registration Statement that indicates that all securities offered have been sold or that deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in the Registration
        Statement and to be a part hereof from the date of the filing of such documents (other than current reports furnished under Items 2.02, 7.01 or 9.01 of Form 8-K). Any statement contained in a document incorporated or deemed to be incorporated by
        reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein (or in any other subsequently filed document which also is incorporated or deemed to be
        incorporated by reference herein) modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 8.
Exhibits.
Exhibit
Number
Description
4.1
Amended and Restated Certificate of Incorporation of Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 3a to Bristol Myers-Squibb Company's Quarterly Report on
                Form 10-Q for the quarterly period ended June 30, 2005).
4.1A
Certificate of Correction to the Amended and Restated Certificate of Incorporation, effective as of December 24, 2009 (incorporated herein by reference to Exhibit 3b to Bristol
                Myers-Squibb Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2010).
4.1B
Certificate of Amendment to the Amended and Restated Certificate of Incorporation, effective as of May 7, 2010 (incorporated herein by reference to Exhibit 3a to Bristol Myers-Squibb
                Company's Current Report on Form 8-K filed on May 10, 2010).
4.1C
Certificate of Amendment to the Amended and Restated Certificate of Incorporation, effective as of May 7, 2010 (incorporated herein by reference to Exhibit 3b to Bristol Myers-Squibb
                Company's Current Report on Form 8-K filed on May 10, 2010).
4.2
Bylaws of Bristol-Myers Squibb Company, as amended as of November 2, 2016 (incorporated herein by reference to Exhibit 3.1 to Bristol Myers-Squibb Company's Current Report on Form 8-K
                filed on November 4, 2016).
4.3
Contingent Value Rights Agreement, between Bristol Myers Squibb Company and Equiniti Trust Company, dated November 20, 2019 (incorporated by reference to Exhibit 4ccc to Bristol
                Myers-Squibb Company's Form 10-K dated February 24, 2020 and filed on February 24, 2020).
5.1*
Opinion of Kirkland & Ellis LLP.
23.1*
Consent of Deloitte & Touche LLP Independent Registered Public Accounting Firm of Bristol-Myers Squibb Company.
23.2*
Consent of KPMG LLP, independent registered public accounting firm of Celgene Corporation.
23.3*
Consent of Kirkland & Ellis LLP (included in Exhibit 5.1).
24.1
Powers of Attorney (included in the signature pages hereof).
99.1
Bristol-Myers Squibb Company 2017 Stock Incentive Plan (F/K/A Celgene Corporation 2017 Stock Incentive Plan) (incorporated by reference to Exhibit 99.1 to Bristol Myers-Squibb
                Company's Form S-8 filed on November 25, 2019).
99.2
Bristol-Myers Squibb Company 2014 Equity Incentive Plan (F/K/A Celgene Corporation 2014 Equity Incentive Plan) (incorporated by reference to Exhibit 99.2 to Bristol Myers-Squibb
                Company's Form S-8 filed on November 25, 2019).
*
Filed herewith
2
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it
        meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, on the 10th day of March, 2020.
BRISTOL-MYERS SQUIBB COMPANY
By:
/s/ Sandra Leung
Sandra Leung
Executive Vice President and General Counsel
3
POWER OF ATTORNEY
Each person whose signature appears below constitutes and appoints Sandra Leung and Katherine R. Kelly as his or her true and lawful attorneys-in-fact
        and agents, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign the name of each of the undersigned in his or her capacity to any and all amendments
        (including any post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto such said
        attorney-in-fact and agent full power and authority to do and perform each and every act and thing necessary or advisable to be done, as fully to all intents and purposes as the undersigned might or could do in person, and each of the undersigned
        hereby ratifies and confirms that the said attorney-in-fact or agent shall do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this registration statement on Form S-8 has been signed below by the following persons in
        the capacities and on the dates indicated.
Signature
Title
Date
/s/ Giovanni Caforio
Chief Executive Officer and Director (Principal Executive Officer)
March 10, 2020
Giovanni Caforio, M.D.
/s/ David V. Elkins
Chief Financial Officer (Principal Financial Officer)
March 10, 2020
David V. Elkins
/s/ Karen M. Santiago
Senior Vice President and Corporate Controller (Principal Accounting Officer)
March 10, 2020
Karen M. Santiago
/s/ Vicki L. Sato, Ph.D.
Lead Independent Director
March 10, 2020
Vicki L. Sato, Ph.D.
/s/ Peter J. Arduini
Director
March 10, 2020
Peter J. Arduini
/s/ Robert Bertolini
Director
March 10, 2020
Robert Bertolini
/s/ Michael W. Bonney
Director
March 10, 2020
Michael W. Bonney
/s/ Matthew W. Emmens
Director
March 10, 2020
Matthew W. Emmens
/s/ Michael Grobstein
Director
March 10, 2020
Michael Grobstein
/s/ Julia A. Haller
Director
March 10, 2020
Julia A. Haller, M.D.
/s/ Alan J. Lacy
Director
March 10, 2020
Alan J. Lacy
/s/ Dinesh C. Paliwal
Director
March 10, 2020
Dinesh C. Paliwal
/s/ Theodore R. Samuels
Director
March 10, 2020
Theodore R. Samuels
/s/ Gerald L. Storch
Director
March 10, 2020
Gerald L. Storch
/s/ Karen H. Vousden, Ph.D.
Director
March 10, 2020
Karen H. Vousden, Ph.D.
/s/ Phyllis R. Yale
Director
March 10, 2020
Phyllis R. Yale
4