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  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">As filed with the Securities and Exchange Commission on March 15, 2023</div>
  <div>&#160;</div>
  <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">Registration No. 333-</div>
  <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;">
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold; font-size: 14pt;">UNITED STATES</div>
  <font style="font-size: 14pt;"> </font>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold; font-size: 14pt;">SECURITIES AND EXCHANGE COMMISSION</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold; font-size: 12pt;">Washington, D.C. 20549</div>
  <div>&#160;
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  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><br>
    <font style="font-size: 18pt;">FORM S-8</font></div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENT</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">UNDER</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;"> <br>
  </div>
  <div>
    <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000; text-align: center;"> </div>
  <div><br>
  </div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold; font-size: 24pt;">Kronos Bio, Inc.</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"> <br>
  </div>
  <table cellspacing="0" cellpadding="0" border="0" id="zeae6ca69529e4eeaae60b18587560f3b" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

      <tr>
        <td style="width: 49%; vertical-align: top;">
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
        </td>
        <td style="width: 2%; vertical-align: top;" colspan="1">&#160;</td>
        <td style="width: 49%; vertical-align: top;">
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">82-1895605</div>
        </td>
      </tr>
      <tr>
        <td style="width: 49%; vertical-align: top;">
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or other jurisdiction of incorporation or organization)</div>
        </td>
        <td style="width: 2%; vertical-align: top;" colspan="1">&#160;</td>
        <td style="width: 49%; vertical-align: top;">
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer Identification No.)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 49%; vertical-align: middle;">&#160;</td>
        <td style="width: 2%; vertical-align: middle;" colspan="1">&#160;</td>
        <td style="width: 49%; vertical-align: middle;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 49%; vertical-align: top;">
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">1300 So. El Camino Real, Suite 400</div>
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Mateo, California</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;" colspan="1">&#160;</td>
        <td style="width: 49%; vertical-align: bottom;">
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">94402</div>
        </td>
      </tr>
      <tr>
        <td style="width: 49%; vertical-align: top;">
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Address of Principal Executive Offices)</div>
        </td>
        <td style="width: 2%; vertical-align: top;" colspan="1">&#160;</td>
        <td style="width: 49%; vertical-align: top;">
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Zip Code)</div>
        </td>
      </tr>

  </table>
  <div> <br>
  </div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">
    <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000;"><br>
  </div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">2020 Equity Incentive Plan</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">2020 Employee Stock Purchase Plan</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Full titles of the plans)</div>
  <div>&#160;
    <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000; text-align: center;"></div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><br>
    Norbert Bischofberger, Ph.D.</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">President and Chief Executive Officer</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Kronos Bio, Inc.</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">1300 So. El Camino Real, Suite 400</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Mateo, California 94402</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(650) 781-5200</div>
  <div style="text-align: center; color: rgb(0, 0, 0);">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
  <div>&#160;
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  <div> <br>
  </div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">Copies to:</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Charles J. Bair, Esq.</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Asa M. Henin, Esq.</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Cooley LLP</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">10265 Science Center Drive</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California 92121</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(858) 550-6000</div>
  <br>
  <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000; text-align: center;">
  <div style="color: rgb(0, 0, 0);"> <br>
  </div>
  <div style="color: rgb(0, 0, 0);">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large
    accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
  <div>&#160;</div>
  <table cellspacing="0" cellpadding="0" border="0" id="zf23d88b64ea342268e9c3afd8cac307d" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

      <tr>
        <td style="width: 26.63%; vertical-align: top;">
          <div style="color: rgb(0, 0, 0);">Large accelerated filer</div>
        </td>
        <td style="width: 43.29%; vertical-align: top;">
          <div style="color: rgb(0, 0, 0);">&#9744;</div>
        </td>
        <td style="width: 26.64%; vertical-align: top;">
          <div style="color: rgb(0, 0, 0);">Smaller reporting company</div>
        </td>
        <td style="width: 3.43%; vertical-align: top;">
          <div style="text-align: center; color: rgb(0, 0, 0);">&#9746;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 26.63%; vertical-align: top;">
          <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
        </td>
        <td style="width: 43.29%; vertical-align: middle;">
          <div style="color: rgb(0, 0, 0);">&#9746;</div>
        </td>
        <td style="width: 26.64%; vertical-align: top;">
          <div style="color: rgb(0, 0, 0);">Accelerated filer</div>
        </td>
        <td style="width: 3.43%; vertical-align: top;">
          <div style="text-align: center; color: rgb(0, 0, 0);">&#9744;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 26.63%; vertical-align: middle;">&#160;</td>
        <td style="width: 43.29%; vertical-align: middle;">&#160;</td>
        <td style="width: 26.64%; vertical-align: top;">
          <div style="color: rgb(0, 0, 0);">Emerging growth company</div>
        </td>
        <td style="width: 3.43%; vertical-align: middle;">
          <div style="text-align: center; color: rgb(0, 0, 0);">&#9744;</div>
        </td>
      </tr>

  </table>
  <div>&#160;</div>
  <div style="color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
    Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
  <div>&#160;</div>
  <div><font style="color: rgb(0, 0, 0);"> </font>
    <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
  <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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      <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
  </div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">
    <div style="color: #000000; font-weight: bold;">REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E</div>
  </div>
  <div>&#160;</div>
  <div style="color: rgb(0, 0, 0);">This Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which Registration Statements of the Registrant on Form S-8 relating to the same
    employee benefit plans are effective.</div>
  <div>&#160;</div>
  <div>
    <div style="color: #000000;">The Registrant previously registered shares of its Common Stock for issuance under the Kronos Bio, Inc. 2020 Equity Incentive Plan and the Kronos Bio, Inc. Employee Stock Purchase Plan<font style="color: #000000;"> under
        Registration Statements on Form S-8 filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on </font><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014428/kronoss-8.htm">October 9, 2020</a><font style="color: #000000;">
        (File No. 333-249424),&#160; </font><a href="https://www.sec.gov/Archives/edgar/data/0001741830/000174183021000019/kronos-forms8x20210323.htm">March 23, 2021</a><font style="color: #000000;"> (File No. 333-254620), and </font><a href="https://www.sec.gov/Archives/edgar/data/1741830/000114036122006621/ny20002924x3_s8.htm">February 24, 2022</a><font style="color: #000000;"> (File No. 333-262993). Pursuant to General Instruction E to Form S-8, this Registration Statement
        hereby incorporates by reference the contents of the Registration Statements referenced above.</font></div>
  </div>
  <div><br>
  </div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">PART II</div>
  <div><br>
  </div>
  <div>
    <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="z7607e9344f0046f0baddb651d4aa3fab" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;">

        <tr style="vertical-align: top;">
          <td style="vertical-align: top; width: 45pt;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">ITEM 3.</div>
          </td>
          <td style="align: left; vertical-align: top; width: auto;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">INCORPORATION OF DOCUMENTS BY REFERENCE.</div>
          </td>
        </tr>

    </table>
  </div>
  <div><br>
  </div>
  <div style="color: rgb(0, 0, 0);">The following documents filed by the registrant with the SEC are incorporated by reference into this registration statement:</div>
  <div><br>
  </div>
  <table cellspacing="0" cellpadding="0" id="zf3b9bb962aba43b4a43985b71bd095c9" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

      <tr>
        <td style="width: 24.45pt;"><br>
        </td>
        <td style="width: 24.5pt; vertical-align: top; color: #000000;">&#8226;</td>
        <td style="width: auto; vertical-align: top;">
          <div style="color: rgb(0, 0, 0);">the registrant's Annual Report on Form 10-K for the year ended December 31, 2022, filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1741830/000174183023000011/kron-20221231.htm">March
              15, 2023</a>;</div>
        </td>
      </tr>

  </table>
  <div>&#160;</div>
  <table cellspacing="0" cellpadding="0" id="zb7b771dc2828484aaccbda0ac56d547c" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

      <tr>
        <td style="width: 24.45pt;"><br>
        </td>
        <td style="width: 24.5pt; vertical-align: top; color: #000000;">&#8226;</td>
        <td style="width: auto; vertical-align: top;">
          <div>
            <div><font style="color: #000000;">the registrant's Current Reports on Form 8-K, filed with the SEC on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001741830/000174183023000003/kron-20230106.htm">January 9, 2023</a> and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001741830/000174183023000005/kron-20230121.htm">January 26, 2023</a>;</div>
          </div>
        </td>
      </tr>

  </table>
  <div>&#160;</div>
  <table cellspacing="0" cellpadding="0" id="z9b69d74953f141128596041820383425" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

      <tr>
        <td style="width: 24.45pt;"><br>
        </td>
        <td style="width: 24.5pt; vertical-align: top; color: #000000;">&#8226;</td>
        <td style="width: auto; vertical-align: top;">
          <div>
            <div><font style="color: #000000;">the description of the registrant's common stock contained in the registrant's registration statement on </font><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014261/kronos-8xax102020.htm">Form 8-A</a><font style="color: #000000;">, filed with the SEC on October 5, 2020, including any amendments or reports filed for the purpose of
                updating such description.</font></div>
          </div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <div style="color: rgb(0, 0, 0);">All reports and other documents filed by the registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, other than Current Reports furnished under Item 2.02 or Item 7.01
    of Form 8-K and exhibits furnished on such form that relate to such items and other portions of documents that are furnished but not filed or are otherwise not incorporated into registration statements pursuant to the applicable rules promulgated by
    the SEC, after the date of this registration statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to
    be incorporated by reference herein and to be a part of this registration statement from the date of filing such reports and documents. Any statement contained in a document incorporated or deemed to be incorporated herein by reference shall be deemed
    to be modified or superseded for purposes of this registration statement to the extent that a statement herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes that
    statement. Any such statement so modified or superseded shall not constitute a part of this registration statement, except as so modified or superseded. </div>
  <div style="color: rgb(0, 0, 0);"> <br>
  </div>
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      <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
  </div>
  <div>
    <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="z99f5a7dfcac346aa96f1db482ee8cc01" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;">

        <tr style="vertical-align: top;">
          <td style="vertical-align: top; width: 45pt;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">ITEM 8.</div>
          </td>
          <td style="align: left; vertical-align: top; width: auto;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">EXHIBITS.</div>
          </td>
        </tr>

    </table>
  </div>
  <br>
  <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zaae1709d0c0a449e99a821faae953fe4">

      <tr>
        <td style="width: 8%; vertical-align: bottom;">
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Exhibit</div>
          <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Number</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">
          <div style="color: rgb(0, 0, 0);">&#160;&#160;</div>
        </td>
        <td style="width: 90%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; color: rgb(0, 0, 0); font-size: 8pt; font-weight: bold;">Description</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td colspan="2" style="vertical-align: middle;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: center; color: rgb(0, 0, 0);">4.1</div>
        </td>
        <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);">&#160;&#160;</div>
        </td>
        <td style="width: 90%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 255); font-size: 12pt;"><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014473/exhibit31-closing8xkam.htm" style="font-size: 10pt;">Amended and Restated Certificate of Incorporation of the
              Registrant (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K (File no. 001-39592), filed with the SEC on October 14, 2020).</a></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: middle;">&#160;</td>
        <td colspan="2" style="vertical-align: middle;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: center; color: rgb(0, 0, 0);">4.2</div>
        </td>
        <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);">&#160;&#160;</div>
        </td>
        <td style="width: 90%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 255); font-size: 12pt;"><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014473/exhibit32-8xkxamendeda.htm" style="font-size: 10pt;">Amended and Restated Bylaws of the Registrant (incorporated by
              reference to Exhibit 3.2 to the Registrant&#8217;s Current Report on Form 8-K (File no. 001-39592), filed with the SEC on October 14, 2020).</a></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: middle;">&#160;</td>
        <td colspan="2" style="vertical-align: middle;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: center; color: rgb(0, 0, 0);">4.3</div>
        </td>
        <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);">&#160;&#160;</div>
        </td>
        <td style="width: 90%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 255); font-size: 12pt;"><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014248/exhibit41-sx1a1xformof.htm" style="font-size: 10pt;">Form of Common Stock Certificate of the Registrant (incorporated
              by reference to Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form&#160;S-1&#160;(File No.&#160;333-248925), filed with the SEC on September 18, 2020).</a></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: middle;">&#160;</td>
        <td colspan="2" style="vertical-align: middle;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: center; color: rgb(0, 0, 0);">5.1</div>
        </td>
        <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);">&#160;&#160;</div>
        </td>
        <td style="width: 90%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);"><a href="brhc10049729_ex5-1.htm">Opinion of Cooley LLP.</a></div>
        </td>
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      <tr>
        <td style="width: 8%; vertical-align: middle;">&#160;</td>
        <td colspan="2" style="vertical-align: middle;">&#160;</td>
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        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
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        <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);">&#160;&#160;</div>
        </td>
        <td style="width: 90%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);"><a href="brhc10049729_ex23-1.htm">Consent of Independent Registered Public Accounting Firm.</a></div>
        </td>
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        <td style="width: 8%; vertical-align: middle;">&#160;</td>
        <td colspan="2" style="vertical-align: middle;">&#160;</td>
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        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: center; color: rgb(0, 0, 0);">23.2</div>
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        <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);">&#160;&#160;</div>
        </td>
        <td style="width: 90%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);"><a href="brhc10049729_ex5-1.htm">Consent of Cooley LLP. Reference is made to&#160;Exhibit 5.1.</a></div>
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        <td style="width: 8%; vertical-align: middle;">&#160;</td>
        <td colspan="2" style="vertical-align: middle;">&#160;</td>
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        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: center; color: rgb(0, 0, 0);">24.1</div>
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        <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);">&#160;&#160;</div>
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        <td style="width: 90%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);"><a href="#POWEROFATTORNEY">Power of Attorney. Reference is made to the signature page hereto.</a></div>
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        <td style="width: 8%; vertical-align: middle;">&#160;</td>
        <td colspan="2" style="vertical-align: middle;">&#160;</td>
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        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: center; color: rgb(0, 0, 0);">99.1</div>
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        <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);">&#160;&#160;</div>
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        <td style="width: 90%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 255); font-size: 12pt;"><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014428/exhibit992-sx8xkronosbioin.htm" style="font-size: 10pt;">Kronos Bio, Inc. 2020 Equity Incentive Plan, and Forms of
              Option Grant Notice, Option Agreement, Notice of Exercise, Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement thereunder (incorporated by reference to Exhibit 99.2 to the Registrant&#8217;s Registration Statement on Form S-8
              (File No. 333-249424), filed with the SEC on October 9, 2020).</a></div>
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        <td style="width: 8%; vertical-align: middle;">&#160;</td>
        <td colspan="2" style="vertical-align: middle;">&#160;</td>
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        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: center; color: rgb(0, 0, 0);">99.2</div>
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        <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
          <div style="color: rgb(0, 0, 0);">&#160;&#160;</div>
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        <td style="width: 90%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="font-size: 12pt;"><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014428/exhibit993-sx8xkronosbioin.htm" style="font-size: 10pt;">Kronos Bio, Inc. 2020 Employee Stock Purchase Plan (incorporated by reference to
              Exhibit 99.3 to the Registrant&#8217;s Registration Statement on Form S-8 (File No. 333-249424), filed with the SEC on October 9, 2020).</a></div>
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        <td style="width: 8%; vertical-align: top;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 90%; vertical-align: top;">&#160;</td>
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        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: center; color: rgb(0, 0, 0);">107</div>
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        <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
        <td style="width: 90%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div><a href="brhc10049729_ex107.htm">Filing fee table.</a></div>
        </td>
      </tr>

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  <div> <br>
  </div>
  <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">SIGNATURES</div>
  <div>&#160;</div>
  <div style="text-indent: 24.5pt; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
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        <td style="width: 3%; vertical-align: middle;">&#160;</td>
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          <div style="color: rgb(0, 0, 0); margin-left: 9pt;">/s/ Norbert Bischofberger</div>
        </td>
        <td style="width: 67%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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        <td style="width: 3%; vertical-align: middle;">&#160;</td>
        <td style="vertical-align: bottom;" colspan="2">
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        </td>
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  </table>
  <div>&#160;</div>
  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">POWER OF ATTORNEY<a name="POWEROFATTORNEY"><!--Anchor--></a></div>
  <div>&#160;</div>
  <div style="color: rgb(0, 0, 0);">KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Norbert Bischofberger, Ph.D., and Barbara Kosacz, and each of them, as his or her true and lawful attorneys-in-fact and
    agents, each with the full power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this registration statement (including post-effective amendments), and to file the
    same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and
    thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitute or
    substitutes, may lawfully do or cause to be done by virtue hereof.</div>
  <div>&#160;</div>
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  <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
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        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
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        </td>
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        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
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        <td style="width: 32.49%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="text-align: center;">/s/ Norbert Bischofberger</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
          <div style="text-align: center;">President, Chief Executive Officer and Director</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">
          <div style="text-align: center;">March 15, 2023</div>
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      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">
          <div style="text-align: center;">Norbert Bischofberger, Ph.D.</div>
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        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
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        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="text-align: center;">/s/ Yasir Al-Wakeel</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
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        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">
          <div style="text-align: center;">March 15, 2023</div>
        </td>
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      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">
          <div style="text-align: center;">Yasir Al-Wakeel, BM BCh</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
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        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="text-align: center;">/s/ Arie Belldegrun</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
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        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">
          <div style="text-align: center;">March 15, 2023</div>
        </td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">
          <div style="text-align: center;">Arie Belldegrun, M.D. FACS</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="text-align: center;">/s/ Marianne De Backer</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
          <div style="text-align: center;">Director</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">
          <div style="text-align: center;">March 15, 2023</div>
        </td>
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      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">
          <div style="text-align: center;">Marianne De Backer, Ph.D.</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="text-align: center;">/s/ Roshawn Blunt</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
          <div style="text-align: center;">Director</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">
          <div style="text-align: center;">March 15, 2023</div>
        </td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">
          <div style="text-align: center;">Roshawn Blunt</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-bottom: #000000 2px solid;">
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        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
          <div style="text-align: center;">Director</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">
          <div style="text-align: center;">March 15, 2023</div>
        </td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">
          <div style="text-align: center;">Joshua Kazam</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-bottom: #000000 2px solid;">
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        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
          <div style="text-align: center;">Director</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">
          <div style="text-align: center;">March 15, 2023</div>
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      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">
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        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
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        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
          <div style="text-align: center;">Director</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">
          <div style="text-align: center;">March 15, 2023</div>
        </td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">
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        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
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        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
          <div style="text-align: center;">Director</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">
          <div style="text-align: center;">March 15, 2023</div>
        </td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">
          <div style="text-align: center;">David Tanen</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
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        <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>
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          <div style="text-align: center;">/s/ Taiyin Yang</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">
          <div style="text-align: center;">Director</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">
          <div style="text-align: center;">March 15, 2023</div>
        </td>
      </tr>
      <tr>
        <td style="width: 32.49%; vertical-align: bottom; border-top: #000000 2px solid;">
          <div style="text-align: center;">Taiyin Yang, Ph.D.</div>
        </td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 45%; vertical-align: bottom;">&#160;</td>
        <td style="width: 2%; vertical-align: bottom;">&#160;</td>
        <td style="width: 19%; vertical-align: bottom;">&#160;</td>
      </tr>

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{"company-data": {"conformed-name": "Kronos Bio, Inc.", "cik": "0001741830", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-270564", "film-number": "23735502"}, "business-address": {"street1": "1300 S. EL CAMINO REAL", "street2": "SUITE 400", "city": "SAN MATEO", "state": "CA", "zip": "94402", "phone": "(650) 781-5200"}, "mail-address": {"street1": "1300 S. EL CAMINO REAL", "street2": "SUITE 400", "city": "SAN MATEO", "state": "CA", "zip": "94402"}}
As filed with the Securities and Exchange Commission on March 15, 2023
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Kronos Bio, Inc.
(Exact name of registrant as specified in its charter)
Delaware
82-1895605
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
1300 So. El Camino Real, Suite 400
San Mateo, California
94402
(Address of Principal Executive Offices)
(Zip Code)
2020 Equity Incentive Plan
2020 Employee Stock Purchase Plan
(Full titles of the plans)
Norbert Bischofberger, Ph.D.
President and Chief Executive Officer
Kronos Bio, Inc.
1300 So. El Camino Real, Suite 400
San Mateo, California 94402
(650) 781-5200
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
Charles J. Bair, Esq.
Asa M. Henin, Esq.
Cooley LLP
10265 Science Center Drive
San Diego, California 92121
(858) 550-6000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large
    accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Smaller reporting company
☒
Non-accelerated filer
☒
Accelerated filer
☐
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
    Section 7(a)(2)(B) of the Securities Act. ☐
REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E
This Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which Registration Statements of the Registrant on Form S-8 relating to the same
    employee benefit plans are effective.
The Registrant previously registered shares of its Common Stock for issuance under the Kronos Bio, Inc. 2020 Equity Incentive Plan and the Kronos Bio, Inc. Employee Stock Purchase Plan
under
        Registration Statements on Form S-8 filed with the Securities and Exchange Commission (the "SEC") on
October 9, 2020
(File No. 333-249424),
March 23, 2021
(File No. 333-254620), and
February 24, 2022
(File No. 333-262993). Pursuant to General Instruction E to Form S-8, this Registration Statement
        hereby incorporates by reference the contents of the Registration Statements referenced above.
PART II
ITEM 3.
INCORPORATION OF DOCUMENTS BY REFERENCE.
The following documents filed by the registrant with the SEC are incorporated by reference into this registration statement:
•
the registrant's Annual Report on Form 10-K for the year ended December 31, 2022, filed with the SEC on
March
              15, 2023
;
•
the registrant's Current Reports on Form 8-K, filed with the SEC on
January 9, 2023
and
January 26, 2023
;
•
the description of the registrant's common stock contained in the registrant's registration statement on
Form 8-A
, filed with the SEC on October 5, 2020, including any amendments or reports filed for the purpose of
                updating such description.
All reports and other documents filed by the registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, other than Current Reports furnished under Item 2.02 or Item 7.01
    of Form 8-K and exhibits furnished on such form that relate to such items and other portions of documents that are furnished but not filed or are otherwise not incorporated into registration statements pursuant to the applicable rules promulgated by
    the SEC, after the date of this registration statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to
    be incorporated by reference herein and to be a part of this registration statement from the date of filing such reports and documents. Any statement contained in a document incorporated or deemed to be incorporated herein by reference shall be deemed
    to be modified or superseded for purposes of this registration statement to the extent that a statement herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes that
    statement. Any such statement so modified or superseded shall not constitute a part of this registration statement, except as so modified or superseded.
ITEM 8.
EXHIBITS.
Exhibit
Number
Description
4.1
Amended and Restated Certificate of Incorporation of the
              Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File no. 001-39592), filed with the SEC on October 14, 2020).
4.2
Amended and Restated Bylaws of the Registrant (incorporated by
              reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K (File no. 001-39592), filed with the SEC on October 14, 2020).
4.3
Form of Common Stock Certificate of the Registrant (incorporated
              by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form S-1 (File No. 333-248925), filed with the SEC on September 18, 2020).
5.1
Opinion of Cooley LLP.
23.1
Consent of Independent Registered Public Accounting Firm.
23.2
Consent of Cooley LLP. Reference is made to Exhibit 5.1.
24.1
Power of Attorney. Reference is made to the signature page hereto.
99.1
Kronos Bio, Inc. 2020 Equity Incentive Plan, and Forms of
              Option Grant Notice, Option Agreement, Notice of Exercise, Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement thereunder (incorporated by reference to Exhibit 99.2 to the Registrant's Registration Statement on Form S-8
              (File No. 333-249424), filed with the SEC on October 9, 2020).
99.2
Kronos Bio, Inc. 2020 Employee Stock Purchase Plan (incorporated by reference to
              Exhibit 99.3 to the Registrant's Registration Statement on Form S-8 (File No. 333-249424), filed with the SEC on October 9, 2020).
107
Filing fee table.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
    and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Mateo, State of California, on March 15, 2023.
KRONOS BIO, INC.
By:
/s/ Norbert Bischofberger
Norbert Bischofberger, Ph.D.
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Norbert Bischofberger, Ph.D., and Barbara Kosacz, and each of them, as his or her true and lawful attorneys-in-fact and
    agents, each with the full power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this registration statement (including post-effective amendments), and to file the
    same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and
    thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitute or
    substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Norbert Bischofberger
President, Chief Executive Officer and Director
March 15, 2023
Norbert Bischofberger, Ph.D.
(Principal Executive Officer)
/s/ Yasir Al-Wakeel
Chief Financial Officer and Head of Corporate Development
March 15, 2023
Yasir Al-Wakeel, BM BCh
(Principal Financial and Accounting Officer)
/s/ Arie Belldegrun
Chair of the Board of Directors
March 15, 2023
Arie Belldegrun, M.D. FACS
/s/ Marianne De Backer
Director
March 15, 2023
Marianne De Backer, Ph.D.
/s/ Roshawn Blunt
Director
March 15, 2023
Roshawn Blunt
/s/ Joshua Kazam
Director
March 15, 2023
Joshua Kazam
/s/ Elena Ridloff
Director
March 15, 2023
Elena Ridloff, CFA
/s/ Otello Stampacchia
Director
March 15, 2023
Otello Stampacchia, Ph.D.
/s/ David Tanen
Director
March 15, 2023
David Tanen
/s/ Taiyin Yang
Director
March 15, 2023
Taiyin Yang, Ph.D.