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  <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">As filed with the Securities and Exchange Commission on March 27, 2024</div>
  <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">Registration No. 333-</div>
  <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">
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    <div style="text-align: center; font-size: 14pt;">UNITED STATES</div>
    <div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">WASHINGTON, D.C.&#160; 20549</div>
      <div style="text-align: left;">&#160;</div>
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        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"> </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">UNDER</div>
      <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">
        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"> </div>
      <div>&#160;</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;">Gyre Therapeutics, Inc.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"> </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z1981325175a74d7eb688ac9fd0efbaa1">

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              <div style="text-align: center; color: #000000; font-weight: bold;">Delaware</div>
            </td>
            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">56-2020050</div>
            </td>
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          <tr>
            <td rowspan="1" style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or Other Jurisdiction of</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Incorporation or Organization)</div>
            </td>
            <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
            <td rowspan="1" style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Identification No.)</div>
            </td>
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      <div><br>
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      <div style="text-align: center; color: #000000; font-weight: bold;">Gyre Therapeutics, Inc.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">12770 High Bluff Drive, Suite 150</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">San Diego, California 92130</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: normal;">(Address, including zip code, of registrant&#8217;s principal executive offices)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: normal;">(Full title of the plan)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Han Ying, Ph.D.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Chief Executive Officer</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Gyre Therapeutics, Inc.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">12770 High Bluff Drive, Suite 150</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">San Diego, California 92130</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(619) 949-3681</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: normal;">&#160;(Name, address and telephone number (including area code) of agent for service)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0);">Copy to:</div>
      <div>&#160;</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Sean Feller</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Gibson, Dunn &amp; Crutcher LLP</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">2029 Century Park East, Suite 4000</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Los Angeles, CA 90067-3026</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(310) 552-8500</div>
      <div>
        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;">&#160;</div>
      <div style="text-align: left; color: rgb(0, 0, 0); font-weight: normal;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth
        company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer&#8221;, &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
      <div style="text-align: left;"><font style="color: rgb(0, 0, 0);"> </font><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z8c8a62372dce435a9c0a015a2ab6254a">

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            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">Large accelerated filer</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9744;</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">Accelerated filer</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9744;</div>
            </td>
          </tr>
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            <td style="width: 25%; vertical-align: middle;">&#160;</td>
            <td style="width: 25%; vertical-align: middle;">&#160;</td>
            <td style="width: 25%; vertical-align: middle;">&#160;</td>
            <td style="width: 25%; vertical-align: middle;">&#160;</td>
          </tr>
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            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9746;</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">Smaller reporting company</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9746;</div>
            </td>
          </tr>
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            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
            <td style="width: 25%; vertical-align: bottom;">&#160;</td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">Emerging growth company</div>
            </td>
            <td style="width: 25%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9744;</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <font style="color: rgb(0, 0, 0);"></font>
      <div>
        <div style="text-align: left;"><font style="font-weight: normal;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
            accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.&#160; &#9744;</font></div>
        <div style="text-align: left;"><font style="font-weight: normal;"> <br>
          </font></div>
        <div style="text-align: left;">
          <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><font style="font-weight: normal;"> </font></div>
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      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">EXPLANATORY NOTE</div>
      <div style="font-weight: normal;">&#160;</div>
      <div style="text-align: left; text-indent: 36pt;"><font style="color: rgb(0, 0, 0); font-weight: normal;">This Registration Statement on Form S-8 (this &#8220;Registration Statement&#8221;) is being filed pursuant to General Instruction E to Form S-8 for the
          purpose of registering an additional 3,829,780 shares of common stock, par value $0.001 per share (&#8220;Common Stock&#8221;), of Gyre Therapeutics, Inc., a Delaware corporation (&#8220;Registrant&#8221;) under the Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan
          (the &#8220;Plan&#8221;), pursuant to the provisions of the Plan providing for an automatic increase in the number of shares reserved and available for issuance under the Plan on January 1, 2024. In accordance with General Instruction E to Form S-8, this
          Registration Statement hereby incorporates by reference the contents of the Registrant&#8217;s Registration Statement on Form S-8 filed by the Company with respect to the Plan on October 31, 2023 (</font><font style="font-weight: normal;">SEC File No.
          333-275222<font style="color: rgb(0, 0, 0);">), together with all exhibits filed therewith or incorporated therein by reference.</font></font></div>
      <div>&#160;</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">PART II</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
      <div>&#160;</div>
      <div>
        <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="z4d2953a353494fd58a9a2b9515b70119" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;">

            <tr style="vertical-align: top;">
              <td style="text-align: right; vertical-align: top; width: 36pt;">
                <div style="text-align: left; color: #000000; font-weight: bold;">Item 8.</div>
              </td>
              <td style="text-align: left; vertical-align: top; width: auto;">
                <div style="color: #000000; font-weight: bold;">Exhibits.</div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z77d8c06b1676417bae981c64caedd8c1">

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            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);"><u>Exhibit No.</u></div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);"><u>Exhibit Description</u></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.1</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312506103288/dex41.htm">Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Registration
                  Statement on Form S-3/A filed on October 24, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.2</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312515297752/d24322dex31.htm">Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit
                  3.2 to the Registrant&#8217;s Registration Statement on Form S-3/A filed on October 24, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.3</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312517037156/d326649dex31.htm">Second Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to
                  Exhibit 3.3 to the Registrant&#8217;s Registration Statement on Form S-3/A filed on October 24, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.4</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex3-1.htm">Third Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by
                  reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on October 30, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.5</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036122046943/brhc10045912_ex3-1.htm">Certificate of Designation of Series X Convertible Preferred Stock (incorporated by reference to Exhibit 3.4 to the Registrant&#8217;s
                  Registration Statement on Form S-3/A filed on October 24, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.6</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex3-2.htm">Amendment to Certificate of Designation of Preferences, Rights and Limitations of Series X Convertible Preferred Stock (incorporated by
                  reference to Exhibit 3.2 to the Registrant&#8217;s Current Report on Form 8-K filed on October 30, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.7</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123030517/brhc20054638_ex3-1.htm">Certificate of Designation of Preferences, Rights and Limitations of Series Y Preferred Stock (incorporated by reference to Exhibit 3.1
                  to the Registrant&#8217;s Current Report on Form 8-K filed on June 20, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.8</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123042067/brhc20058284_ex3-1.htm">Certificate of Elimination of Series Y Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on
                  Form 8-K filed on August 31, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.9</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312517121994/d375894dex31.htm">Certificate of Designation of Preferences, Rights and Limitations of Series A Convertible Preferred Stock (incorporated by reference to Exhibit
                  3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on April 13, 2017).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.10</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000095017024037242/gyre-ex3_6b.htm">Certificate of Elimination of Series A Preferred Stock (incorporated by reference to Exhibit 3.6(b) to the Registrant&#8217;s Annual Report on Form
                  10-K filed on March 27, 2024).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">4.11</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex3-3.htm">Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Registrant&#8217;s Current Report on Form 8-K
                  filed on October 30, 2023).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">5.1*</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="ef20025363_ex5-1.htm">Opinion of Gibson, Dunn &amp; Crutcher LLP.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">23.1*</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="ef20025363_ex23-1.htm">Consent of Grant Thornton Zhitong Certified Public Accountants LLP.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">23.2*</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div><a href="ef20025363_ex5-1.htm">Consent of Gibson, Dunn &amp; Crutcher LLP (included in Exhibit 5.1).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">24.1*</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="text-align: justify;"><a href="#POWEROFATTORNEY">Power of Attorney (included on the signature page hereto).</a><a name="PowerofAttorneyincludedon"><!--Anchor--></a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">99.1</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="text-align: justify;"><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036123050292/ny20009756x10_ex10-2.htm">Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan (incorporated by reference to Exhibit 10.15 to the
                  Registrant&#8217;s Annual Report on Form 10-K filed on March 27, 2024).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">107*</div>
            </td>
            <td style="width: 92%; vertical-align: top;">
              <div style="text-align: justify;"><a href="ef20025363_ex107-1.htm">Filing Fee Table.</a></div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
      <div style="text-align: justify; color: #000000;">
        <hr noshade="noshade" align="left" style="height: 2px; width: 10%; color: #000000; background-color: #000000; text-align: left; margin-left: 0px; margin-right: auto; border: none;"></div>
      <div style="text-align: left; color: #000000;">*Filed herewith.</div>
      <div style="text-align: left; color: #000000;"> <br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div style="page-break-after: always;" class="BRPFPageBreak">
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      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;"> SIGNATURES</div>
      <div>&#160;</div>
      <div style="text-align: left; text-indent: 36pt; color: rgb(0, 0, 0); font-weight: normal;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all
        of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on March 27, 2024.</div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z20e5893f168d468097f90a1b291a1a2c">

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            <td style="width: 60%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Gyre Therapeutics, Inc.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 35%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 60%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
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            <td style="width: 35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">/s/ Han Ying </div>
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              <div style="color: rgb(0, 0, 0);">Name:</div>
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      <div style="text-align: center; color: #000000; font-weight: bold;">POWER OF ATTORNEY<a name="POWEROFATTORNEY"><!--Anchor--></a></div>
      <div>
        <div style="font-weight: normal;"><br>
        </div>
        <div style="text-align: left; text-indent: 36pt; color: rgb(0, 0, 0); font-weight: normal;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Han Ying and Ruoyu Chen, or either of them,
          severally, the individual&#8217;s true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments, including
          post-effective amendments, to this Registration Statement, and any registration statement relating to the offering covered by this Registration Statement and filed pursuant to Rule 462(b) under the Securities Act of 1933, and to file the same,
          with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and
          thing requisite and necessary to be done, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents or their substitute or substitutes may
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        <div><br>
        </div>
      </div>
      <div style="font-weight: normal;">
        <div style="text-align: left; text-indent: 36pt; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated on March 27, 2024.</div>
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                <div style="color: #000000; font-weight: bold;">Signature</div>
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              <div style="color: #000000;">/s/ Gordon G. Carmichael </div>
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            <td colspan="1" style="width: 1%; vertical-align: middle; padding-bottom: 2px;">&#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: middle; padding-bottom: 2px;">&#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: middle; padding-bottom: 2px;">&#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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            <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
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{"company-data": {"conformed-name": "GYRE THERAPEUTICS, INC.", "cik": "0001124105", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "irs-number": "562020050", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-278291", "film-number": "24793097"}, "business-address": {"street1": "12770 HIGH BLUFF DRIVE, SUITE 150", "city": "SAN DIEGO", "state": "CA", "zip": "92130", "phone": "(619) 949-3681"}, "mail-address": {"street1": "12770 HIGH BLUFF DRIVE, SUITE 150", "city": "SAN DIEGO", "state": "CA", "zip": "92130"}, "former-company": [{"former-conformed-name": "CATALYST BIOSCIENCES, INC.", "date-changed": "20150820"}, {"former-conformed-name": "TARGACEPT INC", "date-changed": "20000919"}]}
As filed with the Securities and Exchange Commission on March 27, 2024
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C.  20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Gyre Therapeutics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
56-2020050
(State or Other Jurisdiction of
Incorporation or Organization)
(I.R.S. Employer
Identification No.)
Gyre Therapeutics, Inc.
12770 High Bluff Drive, Suite 150
San Diego, California 92130
(Address, including zip code, of registrant's principal executive offices)
Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan
(Full title of the plan)
Han Ying, Ph.D.
Chief Executive Officer
Gyre Therapeutics, Inc.
12770 High Bluff Drive, Suite 150
San Diego, California 92130
(619) 949-3681
(Name, address and telephone number (including area code) of agent for service)
Copy to:
Sean Feller
Gibson, Dunn & Crutcher LLP
2029 Century Park East, Suite 4000
Los Angeles, CA 90067-3026
(310) 552-8500
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth
        company. See the definitions of "large accelerated filer," "accelerated filer", "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
            accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.  ☐
EXPLANATORY NOTE
This Registration Statement on Form S-8 (this "Registration Statement") is being filed pursuant to General Instruction E to Form S-8 for the
          purpose of registering an additional 3,829,780 shares of common stock, par value $0.001 per share ("Common Stock"), of Gyre Therapeutics, Inc., a Delaware corporation ("Registrant") under the Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan
          (the "Plan"), pursuant to the provisions of the Plan providing for an automatic increase in the number of shares reserved and available for issuance under the Plan on January 1, 2024. In accordance with General Instruction E to Form S-8, this
          Registration Statement hereby incorporates by reference the contents of the Registrant's Registration Statement on Form S-8 filed by the Company with respect to the Plan on October 31, 2023 (
SEC File No.
          333-275222
), together with all exhibits filed therewith or incorporated therein by reference.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 8.
Exhibits.
Exhibit No.
Exhibit Description
4.1
Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Registration
                  Statement on Form S-3/A filed on October 24, 2023).
4.2
Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit
                  3.2 to the Registrant's Registration Statement on Form S-3/A filed on October 24, 2023).
4.3
Second Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to
                  Exhibit 3.3 to the Registrant's Registration Statement on Form S-3/A filed on October 24, 2023).
4.4
Third Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by
                  reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on October 30, 2023).
4.5
Certificate of Designation of Series X Convertible Preferred Stock (incorporated by reference to Exhibit 3.4 to the Registrant's
                  Registration Statement on Form S-3/A filed on October 24, 2023).
4.6
Amendment to Certificate of Designation of Preferences, Rights and Limitations of Series X Convertible Preferred Stock (incorporated by
                  reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K filed on October 30, 2023).
4.7
Certificate of Designation of Preferences, Rights and Limitations of Series Y Preferred Stock (incorporated by reference to Exhibit 3.1
                  to the Registrant's Current Report on Form 8-K filed on June 20, 2023).
4.8
Certificate of Elimination of Series Y Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on
                  Form 8-K filed on August 31, 2023).
4.9
Certificate of Designation of Preferences, Rights and Limitations of Series A Convertible Preferred Stock (incorporated by reference to Exhibit
                  3.1 to the Registrant's Current Report on Form 8-K filed on April 13, 2017).
4.10
Certificate of Elimination of Series A Preferred Stock (incorporated by reference to Exhibit 3.6(b) to the Registrant's Annual Report on Form
                  10-K filed on March 27, 2024).
4.11
Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Registrant's Current Report on Form 8-K
                  filed on October 30, 2023).
5.1*
Opinion of Gibson, Dunn & Crutcher LLP.
23.1*
Consent of Grant Thornton Zhitong Certified Public Accountants LLP.
23.2*
Consent of Gibson, Dunn & Crutcher LLP (included in Exhibit 5.1).
24.1*
Power of Attorney (included on the signature page hereto).
99.1
Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan (incorporated by reference to Exhibit 10.15 to the
                  Registrant's Annual Report on Form 10-K filed on March 27, 2024).
107*
Filing Fee Table.
*Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all
        of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on March 27, 2024.
Gyre Therapeutics, Inc.
By:
/s/ Han Ying
Name:
Han Ying, Ph.D.
Title:
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Han Ying and Ruoyu Chen, or either of them,
          severally, the individual's true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments, including
          post-effective amendments, to this Registration Statement, and any registration statement relating to the offering covered by this Registration Statement and filed pursuant to Rule 462(b) under the Securities Act of 1933, and to file the same,
          with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and
          thing requisite and necessary to be done, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents or their substitute or substitutes may
          lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated on March 27, 2024.
Signature
Title
Date
/s/ Han Ying
Chief Executive Officer and Director (
Principal Executive Officer
)
March 27, 2024
Han Ying, Ph.D.
/s/ Ruoyu Chen
Chief Financial Officer (
Principal Financial and Accounting Officer
)
March 27, 2024
Ruoyu Chen
Chairman of the Board of Directors
Ying Luo, Ph.D.
/s/ Gordon G. Carmichael
Director
March 27, 2024
Gordon G. Carmichael, Ph.D.
/s/ Renate Parry
Director
March 27, 2024
Renate Parry, Ph.D.
/s/ Thomas Eastling
Director
March 27, 2024
Thomas Eastling
/s/ Nassim Usman
Director
March 27, 2024
Nassim Usman, Ph.D.
Director
Songjiang Ma
/s/ Rodney L. Nussbaum
Director
March 27, 2024
Rodney L. Nussbaum