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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-align: center">As filed with the Securities and Exchange
Commission on December 1, 2011</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: right; border-bottom: Black 3.75pt double">Registration
No. 333-</P>

<P STYLE="font: bold 15pt Times New Roman, Times, Serif; margin: 0; text-transform: uppercase; text-align: center">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-transform: uppercase; text-align: center">WASHINGTON,
D.C. 20549</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-transform: uppercase; text-align: center">___________________</P>

<P STYLE="font: bold 15pt Times New Roman, Times, Serif; margin: 0; text-transform: uppercase; text-align: center">FORM S-8</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-transform: uppercase; text-align: center">REGISTRATION
STATEMENT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-transform: uppercase; text-align: center">UNDER THE SECURITIES
ACT OF 1933</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-transform: uppercase; text-align: center">___________________</P>

<P STYLE="font: bold 15pt Times New Roman, Times, Serif; margin: 0; text-transform: uppercase; text-align: center">GUIDED THERAPEUTICS,
INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center">(Exact name of registrant as specified
in its charter)</P>

<TABLE ALIGN="CENTER" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-left: 53.4pt; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 36%; padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; font-weight: bold; text-align: center">DELAWARE</TD>
    <TD STYLE="width: 26%; padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; font-weight: bold; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 38%; padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; font-weight: bold; text-align: center">58-2029543</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-indent: 0in; text-align: center">(State or other jurisdiction of incorporation or organization)</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in; text-align: center">(I.R.S. Employer Identification No.)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>5835 Peachtree Corners East, Suite D</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Norcross, Georgia 30092</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Address of Principal Executive Offices) (Zip
Code)</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-transform: uppercase; text-align: center">___________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>1995 STOCK PLAN</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Full title of the plan)</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-transform: uppercase; text-align: center">___________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Mark L. Faupel</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>President and Chief Executive Officer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Guided Therapeutics, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>5835 Peachtree Corners East, Suite D</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Norcross, Georgia 30092</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(770) 242-8723</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; text-indent: 0.5in">(Telephone number, including
area code, of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center"><B><I>WITH A COPY TO:</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Heith D. Rodman, Esq. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Jones Day</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>1420 Peachtree Street, N.E.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Suite 800</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Atlanta, Georgia 30309-3053</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(404) 521-3939</B></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="line-height: 101%">Indicate by check mark whether the
registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the
definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo;
in Rule 12b-2 of the Exchange Act.</FONT></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="line-height: 101%">&nbsp;</FONT></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="line-height: 101%"></FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%">
<TR STYLE="vertical-align: bottom; text-align: center">
    <TH>&nbsp;</TH>
    <TH>&nbsp;</TH>
    <TH>&nbsp;</TH>
    <TH>&nbsp;</TH></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 11%">&nbsp;</TD>
    <TD STYLE="width: 33%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;Large accelerated filer [ ]</FONT></TD>
    <TD STYLE="width: 9%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="width: 47%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;Accelerated filer [ ]</FONT></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;Non-accelerated filer [ ]</FONT></TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;Smaller reporting company [X]</FONT></TD></TR>
</TABLE>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="line-height: 101%">&nbsp;</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 12pt 0 6pt; text-transform: uppercase; text-align: center">CALCULATION
OF REGISTRATION FEE</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 8pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 29%; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; padding-top: 2pt; padding-bottom: 2pt; text-align: center">Title of securities<BR> to be registered</TD>
    <TD STYLE="width: 20%; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; padding-top: 2pt; padding-bottom: 2pt; text-align: center">Amount to<BR> be registered</TD>
    <TD STYLE="width: 19%; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; padding-top: 2pt; padding-bottom: 2pt; text-align: center">Proposed maximum<BR> offering price<BR> per share</TD>
    <TD STYLE="width: 18%; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; padding-top: 2pt; padding-bottom: 2pt; text-align: center">Proposed maximum<BR> aggregate<BR> offering price</TD>
    <TD STYLE="width: 14%; border-top: windowtext 1pt solid; border-bottom: windowtext 1pt solid; padding-top: 2pt; padding-bottom: 2pt; text-align: center">Amount of<BR> registration fee</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: windowtext 1pt solid; padding-top: 2pt; padding-bottom: 2pt; text-indent: 0in; font-weight: bold">Common Stock, $.01 par value</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; padding-top: 2pt; padding-bottom: 2pt; text-indent: 0in; font-weight: bold; text-align: center">5,800,000 shares(1)</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; padding-top: 2pt; padding-bottom: 2pt; text-indent: 0in; font-weight: bold; text-align: center">$0.95(2)</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; padding-top: 2pt; padding-bottom: 2pt; text-indent: 0in; font-weight: bold; text-align: center">$5,510,000(2)</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; padding-top: 2pt; padding-bottom: 2pt; text-indent: 0in; font-weight: bold; text-align: center">$631.45(2)</TD></TR>
</TABLE>
<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 6pt 0 6pt 23.75pt; text-indent: -23.75pt">(1)&#9;In addition to the
shares set forth in the table, pursuant to Rule 416 of the Securities Act of 1933, the amount to be registered includes an indeterminate
number of shares issuable upon adjustment due to stock splits, stock dividends, and anti-dilution provisions and other adjustment
provisions, as provided in the 1995 Stock Plan.</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0 0 0 23.75pt; text-indent: -23.75pt; border-bottom: Black 4.5pt double">(2)&#9;Estimated
solely for the purpose of calculating the registration fee pursuant to Rule 457(c) under the Securities Act of 1933. Based on the
average of the bid and ask price of the common stock on the OTCQB quotation system on November 28, 2011.</P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-transform: uppercase; text-align: center">STATEMENT
UNDER GENERAL INSTRUCTION E TO FORM S-8</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.25in">This registration statement registers
5,800,000 additional shares of the registrant&rsquo;s common stock, par value $.001 per share, to be issued to participants under
the registrant&rsquo;s 1995 Stock Plan. The contents of the previous registration statement on Form S-8 filed by the registrant
with the Securities and Exchange Commission (the &ldquo;Commission&rdquo;) on June 25, 2001 (Registration No. 333-63758) are incorporated
by reference into this registration statement pursuant to General Instruction E to Form S-8 regarding registration of additional
securities.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-transform: uppercase; text-align: center">PART
II</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-transform: uppercase; text-align: center">INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">Item 8. Exhibits.</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 12%; border-bottom: windowtext 1pt solid; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-indent: 0in; font-size: 9pt; font-weight: bold; text-align: center">Exhibit No.</TD>
    <TD STYLE="width: 2%; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-indent: 0in; font-size: 9pt; font-weight: bold; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 86%; border-bottom: windowtext 1pt solid; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-indent: 0in; font-size: 9pt; font-weight: bold; text-align: center">Description</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.3in; text-indent: 0in; text-align: right">*5.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">Opinion of Jones Day regarding validity.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.3in; text-indent: 0in; text-align: right">10.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">1995 Stock Plan and form of Stock Option Agreement thereunder (incorporated by reference to Exhibit 10.2 to the Registration Statement on Form S-1 (No. 333-22429) filed February 27, 1997).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.3in; text-indent: 0in; text-align: right">10.2</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">2005 Amendment No. 2 to the 1995 Stock Plan, as amended (incorporated by reference to Appendix 1 to the proxy statement on Schedule 14A, filed May 10, 2005).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.3in; text-indent: 0in; text-align: right">*10.3</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">2010 Amendment to the 1995 Stock Plan.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.3in; text-indent: 0in; text-align: right">23.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">Consent of Jones Day (included in Exhibit 5.1).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.3in; text-indent: 0in; text-align: right">*23.2</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">Consent of UHY LLP.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.3in; text-indent: 0in; text-align: right">24.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">Powers of Attorney (included as part of signature page).</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 12pt; text-indent: 0in">_________________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 12pt; text-indent: 0.25in">*filed herewith</P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-transform: uppercase; text-align: center">SIGNATURES</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.25in">Pursuant to the requirements of the
Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Atlanta, State of Georgia, on<BR>
December 1, 2011.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 3.25in">GUIDED THERAPEUTICS, INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 3.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 3.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 3.25in">By: <U>/s/ Mark L. Faupel&#9;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt 3.25in">Name: Mark L. Faupel<BR>
Title: President, Chief Executive Officer and<BR>
Acting Chief Financial Officer</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.25in">KNOW ALL MEN BY THESE PRESENTS, that
each person whose signature appears below constitutes and appoints Mark L. Faupel, with full power of substitution and resubstitution,
as attorney-in-fact of the undersigned, for him and in his name, place and stead, to execute and file with the Securities and Exchange
Commission (the &ldquo;Commission&rdquo;) under the Securities Act of 1933 any and all amendments, supplements and exhibits to
this Registration Statement (including pre-effective and post-effective amendments and supplements), to execute and file any and
all other applications or other documents to be filed with the Commission, such attorney to have full power to act with or without
the others, and to have full power and authority to do and perform, in the name and on behalf of the undersigned, every act whatsoever
necessary, advisable or appropriate to be done in the premises as fully and to all intents and purposes as the undersigned might
or could do in person, hereby ratifying and approving the act of said attorney and any such substitute.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-indent: 0.25in">Pursuant to the requirements of the
Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates
indicated:</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 26%">&nbsp;DATE: December 1, 2011</TD>
    <TD STYLE="width: 10%">&nbsp;</TD>
    <TD STYLE="width: 21%">&nbsp;SIGNATURE</TD>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 41%">&nbsp;TITLE</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; vertical-align: bottom; text-align: left">/s/ Mark L. Faupel</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">President, Chief Executive Officer, Acting Chief Financial Officer and Director (Principal&nbsp;&nbsp; Executive Officer and Principal Financial and Accounting Officer)</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;Mark L. Faupel</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: left; vertical-align: bottom">/s/ Ronald W. Hart</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;Vice Chairman and Director</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;Ronald W. Hart</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: left; vertical-align: bottom">/s/ John E. Imhoff</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;Director</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;John E. Imhoff</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: left; vertical-align: bottom">/s/ Michale C. James</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;Director</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;Michael C. James</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: left; vertical-align: bottom">/s/ Ronald W. Allen</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;Chairman and Director</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;Ronald W. Allen</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: left; vertical-align: bottom">/s/ Ronald W.Allen</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1.5pt">&nbsp;Director</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;Jonathan M. Niloff</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-transform: uppercase; text-align: center">EXHIBIT
INDEX</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 12%; border-bottom: windowtext 1pt solid; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-indent: 0in; font-size: 9pt; font-weight: bold; text-align: center">Exhibit No.</TD>
    <TD STYLE="width: 2%; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-indent: 0in; font-size: 9pt; font-weight: bold; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 86%; border-bottom: windowtext 1pt solid; padding-right: 5.4pt; padding-bottom: 6pt; padding-left: 5.4pt; text-indent: 0in; font-size: 9pt; font-weight: bold; text-align: center">Description</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.3in; text-indent: 0in; text-align: right">5.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">Opinion of Jones Day regarding validity.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.3in; text-indent: 0in; text-align: right">10.3</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">2010 Amendment to the 1995 Stock Plan.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.3in; text-indent: 0in; text-align: right">23.2</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-indent: 0in">Consent of UHY LLP.</TD></TR>
</TABLE>
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[{"type": "S-8", "sequence": "1", "filename": "gthps112111.htm", "description": "GUIDED THERAPEUTICS, INC.", "secsgml_size_bytes": 25799}]
{"company-data": {"conformed-name": "GUIDED THERAPEUTICS INC", "cik": "0000924515", "assigned-sic": "3845", "irs-number": "582029543", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-178261", "film-number": "111237487"}, "business-address": {"street1": "4955 AVALON RIDGE PKWY", "street2": "SUITE 300", "city": "NORCROSS", "state": "GA", "zip": "30071", "phone": "7702428723"}, "mail-address": {"street1": "4955 AVALON RIDGE PKWY", "street2": "SUITE 300", "city": "NORCROSS", "state": "GA", "zip": "30071"}, "former-company": {"former-conformed-name": "SPECTRX INC", "date-changed": "19970226"}}
As filed with the Securities and Exchange
Commission on December 1, 2011
Registration
No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON,
D.C. 20549
___________________
FORM S-8
REGISTRATION
STATEMENT
UNDER THE SECURITIES
ACT OF 1933
___________________
GUIDED THERAPEUTICS,
INC.
(Exact name of registrant as specified
in its charter)
DELAWARE
58-2029543
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
5835 Peachtree Corners East, Suite D
Norcross, Georgia 30092
(Address of Principal Executive Offices) (Zip
Code)
___________________
1995 STOCK PLAN
(Full title of the plan)
___________________
Mark L. Faupel
President and Chief Executive Officer
Guided Therapeutics, Inc.
5835 Peachtree Corners East, Suite D
Norcross, Georgia 30092
(770) 242-8723
(Telephone number, including
area code, of agent for service)
WITH A COPY TO:
Heith D. Rodman, Esq.
Jones Day
1420 Peachtree Street, N.E.
Suite 800
Atlanta, Georgia 30309-3053
(404) 521-3939
Indicate by check mark whether the
registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the
definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company"
in Rule 12b-2 of the Exchange Act.
Large accelerated filer [ ]
Accelerated filer [ ]
Non-accelerated filer [ ]
Smaller reporting company [X]
CALCULATION
OF REGISTRATION FEE
Title of securities
to be registered
Amount to
be registered
Proposed maximum
offering price
per share
Proposed maximum
aggregate
offering price
Amount of
registration fee
Common Stock, $.01 par value
5,800,000 shares(1)
$0.95(2)
$5,510,000(2)
$631.45(2)
(1)	In addition to the
shares set forth in the table, pursuant to Rule 416 of the Securities Act of 1933, the amount to be registered includes an indeterminate
number of shares issuable upon adjustment due to stock splits, stock dividends, and anti-dilution provisions and other adjustment
provisions, as provided in the 1995 Stock Plan.
(2)	Estimated
solely for the purpose of calculating the registration fee pursuant to Rule 457(c) under the Securities Act of 1933. Based on the
average of the bid and ask price of the common stock on the OTCQB quotation system on November 28, 2011.
STATEMENT
UNDER GENERAL INSTRUCTION E TO FORM S-8
This registration statement registers
5,800,000 additional shares of the registrant's common stock, par value $.001 per share, to be issued to participants under
the registrant's 1995 Stock Plan. The contents of the previous registration statement on Form S-8 filed by the registrant
with the Securities and Exchange Commission (the "Commission") on June 25, 2001 (Registration No. 333-63758) are incorporated
by reference into this registration statement pursuant to General Instruction E to Form S-8 regarding registration of additional
securities.
PART
II
INFORMATION
REQUIRED IN THE REGISTRATION STATEMENT
Item 8. Exhibits.
Exhibit No.
Description
*5.1
Opinion of Jones Day regarding validity.
10.1
1995 Stock Plan and form of Stock Option Agreement thereunder (incorporated by reference to Exhibit 10.2 to the Registration Statement on Form S-1 (No. 333-22429) filed February 27, 1997).
10.2
2005 Amendment No. 2 to the 1995 Stock Plan, as amended (incorporated by reference to Appendix 1 to the proxy statement on Schedule 14A, filed May 10, 2005).
*10.3
2010 Amendment to the 1995 Stock Plan.
23.1
Consent of Jones Day (included in Exhibit 5.1).
*23.2
Consent of UHY LLP.
24.1
Powers of Attorney (included as part of signature page).
_________________________
*filed herewith
2
SIGNATURES
Pursuant to the requirements of the
Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Atlanta, State of Georgia, on
December 1, 2011.
GUIDED THERAPEUTICS, INC.
By:
/s/ Mark L. Faupel
Name: Mark L. Faupel
Title: President, Chief Executive Officer and
Acting Chief Financial Officer
KNOW ALL MEN BY THESE PRESENTS, that
each person whose signature appears below constitutes and appoints Mark L. Faupel, with full power of substitution and resubstitution,
as attorney-in-fact of the undersigned, for him and in his name, place and stead, to execute and file with the Securities and Exchange
Commission (the "Commission") under the Securities Act of 1933 any and all amendments, supplements and exhibits to
this Registration Statement (including pre-effective and post-effective amendments and supplements), to execute and file any and
all other applications or other documents to be filed with the Commission, such attorney to have full power to act with or without
the others, and to have full power and authority to do and perform, in the name and on behalf of the undersigned, every act whatsoever
necessary, advisable or appropriate to be done in the premises as fully and to all intents and purposes as the undersigned might
or could do in person, hereby ratifying and approving the act of said attorney and any such substitute.
Pursuant to the requirements of the
Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates
indicated:
DATE: December 1, 2011
SIGNATURE
TITLE
/s/ Mark L. Faupel
President, Chief Executive Officer, Acting Chief Financial Officer and Director (Principal   Executive Officer and Principal Financial and Accounting Officer)
Mark L. Faupel
/s/ Ronald W. Hart
Vice Chairman and Director
Ronald W. Hart
/s/ John E. Imhoff
Director
John E. Imhoff
/s/ Michale C. James
Director
Michael C. James
/s/ Ronald W. Allen
Chairman and Director
Ronald W. Allen
/s/ Ronald W.Allen
Director
Jonathan M. Niloff
3
EXHIBIT
INDEX
Exhibit No.
Description
5.1
Opinion of Jones Day regarding validity.
10.3
2010 Amendment to the 1995 Stock Plan.
23.2
Consent of UHY LLP.
4