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  <div style="text-align: center; color: rgb(0, 0, 0); font-family: &quot;Times New Roman&quot;; font-size: 10pt; font-weight: bold;">As filed with the Securities and Exchange Commission on June 4, 2019.</div>
  <div style="text-align: right;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Registration No. 333&#8209;</font></div>
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  <div style="text-align: center;"><font style="font-size: 14pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">SECURITIES AND EXCHANGE COMMISSION</font></div>
  <div style="text-align: center; font-size: 12pt;"><font style="font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Washington, DC 20549</font></div>
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  <div style="text-align: center;"><font style="font-size: 18pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">FORM S-8</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">REGISTRATION STATEMENT</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">UNDER</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">THE SECURITIES ACT OF 1933</font></div>
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  <div style="text-align: center;"><font style="font-family: &quot;Times New Roman&quot;; font-size: 24pt; font-weight: bold; color: rgb(0, 0, 0);">PDS Biotechnology Corporation</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(Exact name of Registrant as specified in its charter)</font></div>
  <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="z54e2217bce13429b9a6675002d9343a0">

      <tr>
        <td style="width: 33.33%; vertical-align: bottom; background-color: #FFFFFF;">
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Delaware</font></div>
        </td>
        <td style="width: 34%; vertical-align: top; background-color: rgb(255, 255, 255);">
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">300 Connell Drive, Suite 4000</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Berkeley Heights, NJ 07922</font></div>
        </td>
        <td style="width: 33.33%; vertical-align: bottom; background-color: #FFFFFF;">
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">26-4231384</font></div>
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        <td style="width: 33.33%; vertical-align: top; background-color: #FFFFFF;">
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(State of Incorporation)</font></div>
        </td>
        <td style="width: 34%; vertical-align: top; background-color: rgb(255, 255, 255);">
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(Address of principal executive offices)</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(Zip Code)</font></div>
        </td>
        <td style="width: 33.33%; vertical-align: top; background-color: #FFFFFF;">
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(I.R.S. Employer Identification No.)</font></div>
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      <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Amended and Restated PDS Biotechnology Corporation 2014 Equity Incentive Plan</font></div>
      <div style="text-align: center;">
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;
          font-weight: bold; color: rgb(0, 0, 0);"> </font></div>
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  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(Full Title of the Plan)</font></div>
  <div><br>
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  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Frank Bedu-Addo</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">President and Chief Executive Officer</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">PDS Biotechnology Corporation</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">300 Connell Drive, Suite 4000</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Berkeley Heights, NJ 07922</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(Name and address of agent for service)</font></div>
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  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">(800) 208-3343</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(Telephone number, including area code, of agent for service)</font></div>
  <div><br>
  </div>
  <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a
      smaller reporting company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Securities Exchange Act of 1934, as amended. (Check one):</font></div>
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      <tr>
        <td style="width: 13%; vertical-align: middle; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        <td style="width: 35%; vertical-align: middle; background-color: rgb(255, 255, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">Large Accelerated filer&#160; &#9744;<font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"></font></font></div>
        </td>
        <td style="width: 52%; vertical-align: middle; background-color: rgb(255, 255, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">Accelerated filer&#160; &#9744;</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        <td style="width: 35%; vertical-align: top; background-color: rgb(255, 255, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">Non-accelerated filer&#160; &#9746;</font></div>
        </td>
        <td style="width: 52%; vertical-align: middle; background-color: rgb(255, 255, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">Smaller reporting company&#160; &#9746;</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1" colspan="1">&#160;</td>
        <td style="width: 35%; vertical-align: top; background-color: rgb(255, 255, 255);" rowspan="1">&#160;</td>
        <td style="width: 52%; vertical-align: middle; background-color: rgb(255, 255, 255);" rowspan="1">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">Emerging growth company&#160; &#9746;</font></div>
        </td>
      </tr>

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  <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
      complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.&#160; &#9746;</font></div>
  <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);"> <br>
    </font></div>
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    <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><font style="font-size: 10pt;
      font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);"> </font></div>
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      <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">CALCULATION OF REGISTRATION FEE</font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);"> <br>
    </font></div>
  <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" id="zd1628541136b4893a288af1fed47d3ee">

      <tr>
        <td valign="bottom" style="vertical-align: middle; padding-bottom: 2px; width: 56%;">
          <div style="text-align: center; text-indent: -9pt; margin-left: 9pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Title of securities to be registered<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></font></div>
        </td>
        <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Amount to </font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">be</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">registered</font><font style="font-weight:
                normal;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></font></font></div>
        </td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Proposed</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">maximum</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">offering price </font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">per</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">share<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></font></div>
        </td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Proposed</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">maximum</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">aggregate </font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">offering</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">price<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></font></div>
        </td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Amount of</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">registration</font></div>
          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">fee</font></div>
        </td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
      </tr>
      <tr>
        <td valign="bottom" style="vertical-align: top; width: 56%;">
          <div style="text-align: left; text-indent: -9pt; margin-left: 9pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Common Stock, Par Value $0.00033</font></div>
        </td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="2">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="2">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="2">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="2">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
      </tr>
      <tr>
        <td valign="bottom" style="vertical-align: top; width: 56%; background-color: rgb(204, 238, 255);">
          <div style="text-align: left; text-indent: -9pt; margin-left: 9pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Amended and Restated PDS Biotechnology Corporation 2014 Equity Incentive Plan
              (available)</font></div>
        </td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 8%; background-color: rgb(204, 238, 255);" colspan="1">
          <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">826,292</font></div>
        </td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">
          <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">$</font></div>
        </td>
        <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 8%; background-color: rgb(204, 238, 255);" colspan="1">
          <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">7.36</font></div>
        </td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">
          <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">$</font></div>
        </td>
        <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 8%; background-color: rgb(204, 238, 255);" colspan="1">
          <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">6,081,509.12</font></div>
        </td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">
          <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">$</font></div>
        </td>
        <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 8%; background-color: rgb(204, 238, 255);" colspan="1">
          <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">737.08</font></div>
        </td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">&#160;</td>
      </tr>
      <tr>
        <td valign="bottom" style="vertical-align: top; width: 56%; background-color: rgb(255, 255, 255);">
          <div style="text-align: left; text-indent: -9pt; margin-left: 9pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Total</font></div>
        </td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 8%; background-color: rgb(255, 255, 255);" colspan="1">
          <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">826,292</font></div>
        </td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 8%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 8%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
        <td valign="bottom" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">
          <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">$</font></div>
        </td>
        <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 8%; background-color: rgb(255, 255, 255);" colspan="1">
          <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">737.08</font></div>
        </td>
        <td valign="bottom" nowrap="nowrap" style="text-align: left; vertical-align: bottom; width: 1%; background-color: #FFFFFF;" colspan="1">&#160;</td>
      </tr>

  </table>
  <div><br>
  </div>
  <div style="text-align: left;">
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" class="DSPFListTable" id="zb1fe08dcd9e0442589763fa981969b19">

          <tr>
            <td style="width: 40.5pt; vertical-align: top; align: right;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(1)</font></td>
            <td style="width: auto; vertical-align: top; text-align: left;">
              <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">The shares registered by PDS Biotechnology Corporation (the &#8220;<font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;
                    font-weight: bold; font-style: italic;">Registrant</font>&#8221;) on this Form S-8 Registration represent shares of common stock, par value $0.00033 per share (&#8220;<font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;
                    font-weight: bold; font-style: italic;">Common Stock</font>&#8221;), which are issuable under the Amended and Restated PDS Biotechnology Corporation 2014 Equity Incentive Plan (formerly, the Amended and Restated Edge Therapeutics, Inc. 2014
                  Equity Incentive Plan) (the &#8220;<font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; font-style: italic;">2014 Plan</font>&#8221;).</font></div>
            </td>
          </tr>

      </table>
    </div>
  </div>
  <div style="text-align: left;">
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" class="DSPFListTable" id="z5e5935beb12441818ba323b24fb148f3">

          <tr>
            <td style="width: 40.5pt; vertical-align: top; align: right;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(2)</font></td>
            <td style="width: auto; vertical-align: top; text-align: left;">
              <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;<font style="font-size: 10pt; font-family: &quot;Times New
                    Roman&quot;; font-weight: bold; font-style: italic;">Securities Act</font>&#8221;), this Registration Statement shall also cover any additional shares of Common Stock which become issuable under the 2014 Plan by reason of any stock dividend,
                  stock split, recapitalization or other similar transaction effected without the Registrant&#8217;s receipt of consideration that increases the number of the outstanding shares of the Registrant&#8217;s Common Stock.</font></div>
            </td>
          </tr>

      </table>
    </div>
  </div>
  <div style="text-align: left;">
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" class="DSPFListTable" id="zc12ab7df92314943acff85a3f1071e80">

          <tr>
            <td style="width: 40.5pt; vertical-align: top; align: right;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">(3)</font></td>
            <td style="width: auto; vertical-align: top; text-align: left;">
              <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Calculated solely for purposes of this offering under Rule 457(c) and Rule 457(h) of the Securities Act, on the basis of the average of the
                  high and low prices per share of the Registrant&#8217;s Common Stock on May 29, 2019 as reported by the Nasdaq Capital Market.</font></div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
    </div>
  </div>
  <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
    <div style="page-break-after:always;" id="DSPFPageBreak">
      <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
  </div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Part II</font></div>
  <div><br>
  </div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Information Required In The Registration Statement</font></div>
  <div><br>
  </div>
  <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">This Registration Statement relates to the registration of an additional 826,292 shares (the &#8220;<font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; font-style: italic;">Shares</font>&#8221;) of the Registrant&#8217;s Common Stock.&#160; The Shares are securities of the same class and relate to the same employee benefit plan,
      the 2014 Plan, which was amended and restated effective as of March 15, 2019 (in the form attached hereto as Exhibit 99.1), as those registered pursuant to the Registrant&#8217;s registration statements on Form S-8, previously filed with the Securities and
      Exchange Commission on October 21, 2015 (Registration No. 333-207545), March 9, 2016 (Registration No. 333-210041), March 3, 2017 (Registration No. 333-216430), March 2, 2018 (Registration No. 333-223389), and February 22, 2019 (Registration No.
      333-229817). In accordance with General Instruction E of Form S-8, the contents of the Registrant&#8217;s registration statements filed with the Securities and Exchange Commission on <a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001396/s001068x1_s8.htm">October 21, 2015 (Registration No. 333-207545)</a>, <a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761916001984/s001233x1_s8.htm">March 9,
        2016 (Registration No. 333-210041)</a>, <a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036117010512/forms8.htm">March 3, 2017 (Registration No. 333-216430)</a>, <a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036118011463/s002104x1_s8.htm">March 2, 2018 (Registration No. 333-223389)</a> and <a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036119003707/s002686x1_s8.htm">February 22,
        2019 (Registration No. 333-229817)</a> are incorporated herein by reference (solely to the extent the contents of such registration statements relate to the 2014 Plan) and the information required by Part II is omitted, except as supplemented by
      the information set forth below.</font></div>
  <div style="text-align: justify; text-indent: 36pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);"> <br>
    </font></div>
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    <div style="page-break-after:always;" id="DSPFPageBreak">
      <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
  </div>
  <div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;" id="z69c77da2b0164e26a4dcda0d287d96af" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 54pt;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Item 8.</font></div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">Exhibits.</font></div>
            </td>
          </tr>

      </table>
    </div>
  </div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><u> <br>
        </u></font></font></div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><u>Exhibit Index</u></font></font></div>
  <div><br>
  </div>
  <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="z0ccab88a731d412e9745131da363eeaa">

      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Exhibit</font></div>
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Number</font></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);"> </font>&#160;</div>
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Description</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001328/s000911x12_ex3-1.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">4.1</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Eighth Amended and Restated Certificate of Incorporation of PDS Biotechnology Corporation (filed as Exhibit 3.1 to the
              Registrant&#8217;s Current Report on Form 8-K filed with the Commission on October 6, 2015, and incorporated by reference herein).</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036119005071/ex3_1.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">4.2</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Certificate of Amendment to Restated Certificate of Incorporation (filed as Exhibit 3.1 to the Registrant&#8217;s Current
              Report on Form 8-K filed with the Commission on March 18, 2019, and incorporated by reference herein).</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036119005071/ex3_2.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">4.3</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Certificate of Amendment to Restated Certificate of Incorporation (filed as Exhibit 3.2 to the Registrant&#8217;s Current
              Report on Form 8-K filed with the Commission on March 18, 2019, and incorporated by reference herein).</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001328/s000911x12_ex3-2.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">4.4</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Second Amended and Restated Bylaws of PDS Biotechnology Corporation (filed as Exhibit 3.2 to the Registrant&#8217;s Current
              Report on Form 8-K filed with the Commission on October 6, 2015, and incorporated by reference herein).</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001209/s000911x5_ex4-1.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">4.5</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Form of Certificate of Common Stock (filed as Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form S-1 filed
              with the Commission on September 21, 2015, and incorporated by reference herein).</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;" rowspan="1">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="ex5_1.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">5.1</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Opinion and Consent of DLA Piper LLP (US).</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="ex23_1.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">23.1</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Consent of KPMG LLP.</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="ex5_1.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">23.2</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Consent of DLA Piper LLP (US) is contained in Exhibit 5.1.</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="#POWEROFATTORNEY"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">24.1</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Power of Attorney (contained on the signature page hereto).</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="ex99_1.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">99.1</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Amended and Restated PDS Biotechnology Corporation 2014 Equity Incentive Plan.</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="ex99_2.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">99.2</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Form of PDS Biotechnology Corporation Executive Stock Option Agreement.</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
        <td style="width: 92%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
      </tr>
      <tr>
        <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><a href="ex99_3.htm"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">99.3</font></a></div>
        </td>
        <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Form of PDS Biotechnology Corporation Employee Stock Option Agreement.</font></div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
    <div style="page-break-after:always;" id="DSPFPageBreak">
      <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
  </div>
  <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><u>SIGNATURES</u></font></font></div>
  <div><br>
  </div>
  <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable
      grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement with respect to the Amended and Restated PDS Biotechnology Corporation 2014 Equity Incentive Plan, to be signed on its
      behalf by the undersigned, thereunto duly authorized, in the City of Berkeley Heights, State of New Jersey, on June 4, 2019.</font></div>
  <div><br>
  </div>
  <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse;" id="z17c56b1c594540bdb70703471dbf8ddc">

      <tr>
        <td style="width: 50%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        <td colspan="2" style="vertical-align: top; background-color: rgb(255, 255, 255);">
          <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">PDS Biotechnology Corporation</font></div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
        <td colspan="2" style="vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
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  </table>
  <div><br>
  </div>
  <div style="text-align: center;"><a name="POWEROFATTORNEY"><!--Anchor--></a><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold; color: rgb(0, 0, 0);">POWER OF ATTORNEY</font></div>
  <div><br>
  </div>
  <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">The officers and directors of PDS Biotechnology Corporation whose signatures appear below hereby constitute
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  <div><br>
  </div>
  <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the
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          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">Director</font></div>
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          <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">June 4, 2019</font></div>
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[{"type": "S-8", "sequence": "1", "filename": "forms8.htm", "description": "S-8", "secsgml_size_bytes": 65795}]
{"company-data": {"conformed-name": "PDS Biotechnology Corp", "cik": "0001472091", "assigned-sic": "2834", "irs-number": "264231384", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-231943", "film-number": "19876633"}, "business-address": {"street1": "300 CONNELL DRIVE", "street2": "SUITE 4000", "city": "BERKELEY HEIGHTS", "state": "NJ", "zip": "07922", "phone": "800-208-3343"}, "mail-address": {"street1": "300 CONNELL DRIVE", "street2": "SUITE 4000", "city": "BERKELEY HEIGHTS", "state": "NJ", "zip": "07922"}, "former-company": {"former-conformed-name": "Edge Therapeutics, Inc.", "date-changed": "20090911"}}
As filed with the Securities and Exchange Commission on June 4, 2019.
Registration No. 333‑
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
PDS Biotechnology Corporation
(Exact name of Registrant as specified in its charter)
Delaware
300 Connell Drive, Suite 4000
Berkeley Heights, NJ 07922
26-4231384
(State of Incorporation)
(Address of principal executive offices)
(Zip Code)
(I.R.S. Employer Identification No.)
Amended and Restated PDS Biotechnology Corporation 2014 Equity Incentive Plan
(Full Title of the Plan)
Frank Bedu-Addo
President and Chief Executive Officer
PDS Biotechnology Corporation
300 Connell Drive, Suite 4000
Berkeley Heights, NJ 07922
(Name and address of agent for service)
(800) 208-3343
(Telephone number, including area code, of agent for service)
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a
      smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Securities Exchange Act of 1934, as amended. (Check one):
Large Accelerated filer  ☐
Accelerated filer  ☐
Non-accelerated filer  ☒
Smaller reporting company  ☒
Emerging growth company  ☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
      complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.  ☒
CALCULATION OF REGISTRATION FEE
Title of securities to be registered
(1)
Amount to
be
registered
(2)
Proposed
maximum
offering price
per
share
(3)
Proposed
maximum
aggregate
offering
price
(3)
Amount of
registration
fee
Common Stock, Par Value $0.00033
Amended and Restated PDS Biotechnology Corporation 2014 Equity Incentive Plan
              (available)
826,292
$
7.36
$
6,081,509.12
$
737.08
Total
826,292
$
737.08
(1)
The shares registered by PDS Biotechnology Corporation (the "
Registrant
") on this Form S-8 Registration represent shares of common stock, par value $0.00033 per share ("
Common Stock
"), which are issuable under the Amended and Restated PDS Biotechnology Corporation 2014 Equity Incentive Plan (formerly, the Amended and Restated Edge Therapeutics, Inc. 2014
                  Equity Incentive Plan) (the "
2014 Plan
").
(2)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "
Securities Act
"), this Registration Statement shall also cover any additional shares of Common Stock which become issuable under the 2014 Plan by reason of any stock dividend,
                  stock split, recapitalization or other similar transaction effected without the Registrant's receipt of consideration that increases the number of the outstanding shares of the Registrant's Common Stock.
(3)
Calculated solely for purposes of this offering under Rule 457(c) and Rule 457(h) of the Securities Act, on the basis of the average of the
                  high and low prices per share of the Registrant's Common Stock on May 29, 2019 as reported by the Nasdaq Capital Market.
Part II
Information Required In The Registration Statement
This Registration Statement relates to the registration of an additional 826,292 shares (the "
Shares
") of the Registrant's Common Stock.  The Shares are securities of the same class and relate to the same employee benefit plan,
      the 2014 Plan, which was amended and restated effective as of March 15, 2019 (in the form attached hereto as Exhibit 99.1), as those registered pursuant to the Registrant's registration statements on Form S-8, previously filed with the Securities and
      Exchange Commission on October 21, 2015 (Registration No. 333-207545), March 9, 2016 (Registration No. 333-210041), March 3, 2017 (Registration No. 333-216430), March 2, 2018 (Registration No. 333-223389), and February 22, 2019 (Registration No.
      333-229817). In accordance with General Instruction E of Form S-8, the contents of the Registrant's registration statements filed with the Securities and Exchange Commission on
October 21, 2015 (Registration No. 333-207545)
,
March 9,
        2016 (Registration No. 333-210041)
,
March 3, 2017 (Registration No. 333-216430)
,
March 2, 2018 (Registration No. 333-223389)
and
February 22,
        2019 (Registration No. 333-229817)
are incorporated herein by reference (solely to the extent the contents of such registration statements relate to the 2014 Plan) and the information required by Part II is omitted, except as supplemented by
      the information set forth below.
Item 8.
Exhibits.
Exhibit Index
Exhibit
Number
Description
4.1
Eighth Amended and Restated Certificate of Incorporation of PDS Biotechnology Corporation (filed as Exhibit 3.1 to the
              Registrant's Current Report on Form 8-K filed with the Commission on October 6, 2015, and incorporated by reference herein).
4.2
Certificate of Amendment to Restated Certificate of Incorporation (filed as Exhibit 3.1 to the Registrant's Current
              Report on Form 8-K filed with the Commission on March 18, 2019, and incorporated by reference herein).
4.3
Certificate of Amendment to Restated Certificate of Incorporation (filed as Exhibit 3.2 to the Registrant's Current
              Report on Form 8-K filed with the Commission on March 18, 2019, and incorporated by reference herein).
4.4
Second Amended and Restated Bylaws of PDS Biotechnology Corporation (filed as Exhibit 3.2 to the Registrant's Current
              Report on Form 8-K filed with the Commission on October 6, 2015, and incorporated by reference herein).
4.5
Form of Certificate of Common Stock (filed as Exhibit 4.1 to the Registrant's Registration Statement on Form S-1 filed
              with the Commission on September 21, 2015, and incorporated by reference herein).
5.1
Opinion and Consent of DLA Piper LLP (US).
23.1
Consent of KPMG LLP.
23.2
Consent of DLA Piper LLP (US) is contained in Exhibit 5.1.
24.1
Power of Attorney (contained on the signature page hereto).
99.1
Amended and Restated PDS Biotechnology Corporation 2014 Equity Incentive Plan.
99.2
Form of PDS Biotechnology Corporation Executive Stock Option Agreement.
99.3
Form of PDS Biotechnology Corporation Employee Stock Option Agreement.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable
      grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement with respect to the Amended and Restated PDS Biotechnology Corporation 2014 Equity Incentive Plan, to be signed on its
      behalf by the undersigned, thereunto duly authorized, in the City of Berkeley Heights, State of New Jersey, on June 4, 2019.
PDS Biotechnology Corporation
By:
/s/ Frank Bedu-Addo
Name:
Frank Bedu-Addo
Title
President and Chief Executive Officer
POWER OF ATTORNEY
The officers and directors of PDS Biotechnology Corporation whose signatures appear below hereby constitute
      and appoint Frank Bedu-Addo and Andrew Saik, and each of them, their true and lawful attorneys and agents, with full power of substitution, each with power to act alone, to sign and execute on behalf of the undersigned this Registration Statement on
      Form S-8 with respect to the Amended and Restated PDS Biotechnology 2014 Equity Incentive Plan, and any amendment or amendments thereto, and each of the undersigned does hereby ratify and confirm all that each attorney and agent, or his or her
      substitutes, shall do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the
      following persons in the capacities and on the date indicated.
Signature
Title
Date
/s/ Frank Bedu-Addo
President, Chief Executive Officer and Director
June 4, 2019
Frank Bedu-Addo
(Principal Executive Officer)
/s/ Andrew Saik
Chief Financial Officer and Director
June 4, 2019
Andrew Saik
(Principal Financial and Accounting Officer)
/s/ Sir Richard Sykes
Director
June 4, 2019
Sir Richard Sykes
/s/ De Lyle W. Bloomquist
Director
June 4, 2019
De Lyle W. Bloomquist
/s/ Gregory Freitag
Director
June 4, 2019
Gregory Freitag
/s/ James Loughlin
Director
June 4, 2019
James Loughlin
/s/ Stephen Glover
Director
June 4, 2019
Stephen Glover