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    <div style="text-align: center;">As filed with the Securities and Exchange Commission on November 14, 2019</div>
    <div><br>
    </div>
    <div style="text-align: right;">Registration No. 333-_________</div>
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      <div style="text-align: center; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    </div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
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    <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div><br>
    </div>
    <div style="text-align: center; font-size: 24pt; font-weight: bold;">PDS Biotechnology Corporation</div>
    <div style="text-align: center;">(Exact name of registrant as specified in its charter)</div>
    <div><br>
    </div>
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            <div style="text-align: center; font-weight: bold;">Delaware</div>
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          <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">26-4231384</div>
          </td>
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          <td rowspan="1" style="width: 49%; vertical-align: top;">
            <div style="text-align: center;">(State or other jurisdiction of incorporation or organization)</div>
          </td>
          <td rowspan="1" colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 49%; vertical-align: top;">
            <div style="text-align: center;">(I.R.S. Employer Identification No.)</div>
          </td>
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          <td rowspan="1" style="width: 49%; vertical-align: top;">&#160;</td>
          <td rowspan="1" colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 49%; vertical-align: top;">&#160;</td>
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          <td rowspan="1" style="width: 49%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">303A College Road East</div>
            <div style="text-align: center; font-weight: bold;">Princeton, NJ</div>
          </td>
          <td rowspan="1" colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 49%; vertical-align: bottom; font-weight: bold; text-align: center;">&#160;08540</td>
        </tr>
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          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center;">(Address of Principal Executive Offices)</div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center;">(Zip Code)</div>
          </td>
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    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">PDS Biotechnology Corporation 2019 Inducement Plan</div>
    <div style="text-align: center;">(Full title of the plans)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Frank Bedu-Addo</div>
    <div style="text-align: center; font-weight: bold;">President and Chief Executive Officer</div>
    <div style="text-align: center; font-weight: bold;">PDS Biotechnology Corporation</div>
    <div style="text-align: center; font-weight: bold;">303A College Road East</div>
    <div style="text-align: center; font-weight: bold;">Princeton, NJ 08540</div>
    <div style="text-align: center; font-weight: bold;">(800) 208-3343</div>
    <div style="text-align: center; font-size: 8pt;"><font style="font-size: 10pt; font-weight: bold;">&#160;</font><font style="font-size: 10pt;">(Name, address and telephone number, including area code, of agent for service)</font></div>
    <div style="text-align: center; font-size: 8pt;"><font style="font-size: 10pt;"> <br>
      </font></div>
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    <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer&#8221; and &#8220;smaller reporting
      company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div><br>
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          <td style="width: 40%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div>Large Accelerated filer&#160; &#9744;</div>
          </td>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div>Accelerated filer&#160; &#9744;</div>
          </td>
        </tr>
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          <td style="width: 40%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div>Non-accelerated filer&#160; &#9746;</div>
          </td>
          <td style="width: 40%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div>Smaller reporting company&#160; &#9746;</div>
          </td>
        </tr>
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          <td style="width: 40%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 40%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div>Emerging growth company&#160; <font style="font-family: 'Segoe UI Symbol',sans-serif;">&#9746;</font></div>
          </td>
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    <div> <br>
    </div>
    <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act.&#160; &#9746;</div>
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    <div style="text-align: center; font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
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            <div style="text-align: center; font-weight: bold; text-indent: -9pt; margin-left: 9pt;">Title of securities to be registered<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="2" style="vertical-align: middle;">
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;">Amount to be </div>
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;">registered<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="2" style="vertical-align: middle;">
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;">Proposed </div>
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;">maximum </div>
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;">offering price per </div>
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;">share<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="2" style="vertical-align: middle;">
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;">Proposed</div>
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;"> maximum</div>
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;"> aggregate offering</div>
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;"> price<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="2" style="vertical-align: middle;">
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;">Amount of </div>
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;">registration </div>
            <div style="text-align: center; font-family: &#38;quot; font-weight: bold;">fee</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
        </tr>
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          <td valign="bottom" style="vertical-align: middle;">
            <div style="text-indent: -9pt; margin-left: 9pt;">Common Stock, Par Value $0.00033</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="2" style="vertical-align: middle;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="2" style="vertical-align: middle;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="2" style="vertical-align: middle;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="2" style="vertical-align: middle;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
        </tr>
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          <td valign="bottom" style="vertical-align: middle; width: 52%; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">PDS Biotechnology Corporation 2019 Inducement Plan</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
            <div style="font-family: &#38;quot;">200,000</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
            <div style="font-family: &#38;quot;">$</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
            <div style="font-family: &#38;quot;">2.91</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
            <div><font style="font-family: &#38;quot;">$</font></div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
            <div>582,000.00</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">
            <div><font style="font-family: &#38;quot;">$</font></div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;">
            <div>75.55</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;">&#160;</td>
        </tr>

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              <td style="width: 18pt; vertical-align: top; align: right;">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div>The shares to be registered by PDS Biotechnology Corporation (the &#8220;<font style="font-weight: bold; font-style: italic;">Registrant</font>&#8221;) on this Form S-8 Registration Statement represent shares of common stock, par value $0.00033
                  per share (&#8220;<font style="font-weight: bold; font-style: italic;">Common Stock</font>&#8221;), which are issuable under the PDS Biotechnology Corporation 2019 Inducement Plan, effective as of June 17, 2019 (the &#8220;<font style="font-weight: bold; font-style: italic;">Inducement Plan</font>&#8221;).</div>
              </td>
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              <td style="width: 18pt; vertical-align: top; align: right;">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div><font style="color: #000000;">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: #000000;">Securities Act</font><font style="color: #000000;">&#8221;),
                    this Registration Statement shall also cover any additional shares of Common Stock that become issuable under the Inducement Plan by reason of any stock dividend, stock split, recapitalization or other similar transaction effected
                    without the Registrant&#8217;s receipt of consideration that increases the number of the outstanding shares of the Registrant&#8217;s Common Stock</font>.</div>
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              </td>
              <td style="width: 18pt; vertical-align: top; align: right;">(3)</td>
              <td style="width: auto; vertical-align: top;">
                <div>Computed in accordance with Rules 457(c) and (h) under the Securities Act, solely for the purpose of calculating the registration fee, based on the average of the high and low prices of the Registrant&#8217;s Common Stock as reported on the
                  Nasdaq Capital Market on November 8, 2019.</div>
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    </div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Proposed sales to take place as soon after the effective date of the Registration Statement</div>
    <div style="text-align: center; font-weight: bold;">as awards under the above-named plan are granted, exercised and/or distributed.</div>
    <div><br>
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    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">PART I</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Information Required in the Section 10(a) Prospectus</div>
    <div><br>
    </div>
    <div>
      <div>
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              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 1.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;">Plan Information.</div>
              </td>
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    <div><br>
    </div>
    <div style="color: rgb(0, 0, 0); text-indent: 36pt;">The documents containing the information specified in Part I will be delivered in accordance with Form S-8 and Rule 428(b)(1) of the Securities Act. Such documents are not required to be, and are
      not, filed with the Securities and Exchange Commission (the &#8220;<font style="font-weight: bold; font-style: italic;">Commission</font>&#8221;), either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424
      under the Securities Act. These documents, and the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Part II of this Form S-8, taken together, constitute a prospectus that meets the requirements of Section 10(a)
      of the Securities Act.</div>
    <div><br>
    </div>
    <div>
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              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 2.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: #000000;"><font style="font-weight: bold;">Registrant Information and Employee Plan Annual Information</font>.</div>
              </td>
            </tr>

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    </div>
    <div><br>
    </div>
    <div style="color: rgb(0, 0, 0); text-indent: 36pt;">The written statement required by Item 2 is included in documents sent or given to participants in the Inducement Plan covered by this Registration Statement pursuant to Rule 428(b)(1) of the
      Securities Act.</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">PART II</div>
    <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div><br>
    </div>
    <div>
      <div>
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              <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 3.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;">Incorporation of Documents by Reference.</div>
              </td>
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      </div>
    </div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">The Registrant hereby incorporates by reference in this Registration Statement the following documents:</div>
    <div>&#160;</div>
    <div style="text-align: justify;">
      <div>
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              </td>
              <td style="width: 18pt; vertical-align: top; align: right;">(a)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div><a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036119003636/form10k.htm"><font style="background-color: rgb(255, 255, 255);">The Registrant&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed
                      with the Commission on February 21, 2019 pursuant to Section 13(a) of the Securities Exchange Act of 1934, as amended (the &#8220;</font><font style="background-color: rgb(255, 255, 255); font-weight: bold; font-style: italic;">Exchange Act</font><font style="background-color: rgb(255, 255, 255);">&#8221;), which contains the Registrant&#8217;s audited financial statements for the latest fiscal year for which such statements have been filed</font><font style="background-color: rgb(255, 255, 255);">;</font></a></div>
              </td>
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              <td style="width: 54pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; align: right;">(b)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div style="color: rgb(0, 0, 0);">All other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Registrant&#8217;s Annual Report on Form 10-K referred to in (a) above; and</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: justify;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2b625db8a32b4f9b86b5de18ddefa6bc">

            <tr>
              <td style="width: 54pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; align: right;">(c)</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001256/s000911x7_8a12b.htm"><font style="background-color: rgb(255, 255, 255);">The description of the Registrant&#8217;s Common Stock, contained in its registration
                      statement on Form 8-A, which was filed with the Commission on September 25, 2015</font><font style="background-color: rgb(255, 255, 255);">.</font></a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; color: #000000;">All reports and definitive proxy or information statements filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this Registration Statement and prior to the filing of
      a post-effective amendment which indicates that all securities offered hereby have been sold or which de-registers all securities then remaining unsold shall be deemed to be incorporated by reference into this Registration Statement and to be a part
      hereof from the date of filing of such documents.&#160; Unless expressly incorporated into this Registration Statement, a report furnished but not filed on Form 8-K under the Exchange Act shall not be incorporated by reference into this Registration
      Statement.&#160; Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein
      or in any subsequently filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement.&#160; Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to
      constitute a part of this Registration Statement.</div>
    <div><br>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zad2ad738f0d44a358bde0c1dbc0e2e7b">

            <tr>
              <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 4.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;">Description of Securities.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">Not applicable.</div>
    <div><br>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z30640ab0385c43b99a329e32b4841cf5">

            <tr>
              <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 5.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;">Interests of Named Experts and Counsel.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">Not applicable.</div>
    <div><br>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z125f08f8de7f40688541687df69700b2">

            <tr>
              <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 6.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;">Indemnification of Directors and Officers.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>&#160;</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">The Registrant is incorporated under the laws of the State of Delaware. Section 145 of the Delaware General Corporation Law provides that a Delaware corporation may indemnify any persons who are, or
      are threatened to be made, parties to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of such corporation), by reason of the fact that
      such person was an officer, director, employee or agent of such corporation, or is or was serving at the request of such person as an officer, director, employee or agent of another corporation or enterprise. The indemnity may include expenses
      (including attorneys&#8217; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with such action, suit or proceeding, provided that such person acted in good faith and in a manner he or she
      reasonably believed to be in or not opposed to the corporation&#8217;s best interests and, with respect to any criminal action or proceeding, had no reasonable cause to believe that his or her conduct was illegal. A Delaware corporation may indemnify any
      persons who are, or are threatened to be made, a party to any threatened, pending or completed action or suit by or in the right of the corporation by reason of the fact that such person was a director, officer, employee or agent of such corporation,
      or is or was serving at the request of such corporation as a director, officer, employee or agent of another corporation or enterprise. The indemnity may include expenses (including attorneys&#8217; fees) actually and reasonably incurred by such person in
      connection with the defense or settlement of such action or suit, provided that such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation&#8217;s best interests except that no indemnification
      is permitted without judicial approval if the officer or director is adjudged to be liable to the corporation. Where an officer or director is successful on the merits or otherwise in the defense of any action referred to above, the corporation must
      indemnify him or her against the expenses which such officer or director has actually and reasonably incurred. The Registrant&#8217;s certificate of incorporation and bylaws provide for the indemnification of its directors and officers to the fullest
      extent permitted under the Delaware General Corporation Law.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">Section 102(b)(7) of the Delaware General Corporation Law permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable to the
      corporation or its stockholders for monetary damages for breach of fiduciary duties as a director, except for liability for any:</div>
    <div><br>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zdc59d1909a6d49788ffe2baaefa6a455">

            <tr>
              <td style="width: 18pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
              <td style="width: auto; vertical-align: top;">
                <div>transaction from which the director derives an improper personal benefit;</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z346351f78f574801b4e1fd440b8299e7">

            <tr>
              <td style="width: 18pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
              <td style="width: auto; vertical-align: top;">
                <div>act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z696f620fac2d497494ec124b1c00d9b8">

            <tr>
              <td style="width: 18pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
              <td style="width: auto; vertical-align: top;">
                <div>unlawful payment of dividends or redemption of shares; or</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2b1d67be9d4f41f293d6d3526ffa7342">

            <tr>
              <td style="width: 18pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
              <td style="width: auto; vertical-align: top;">
                <div>breach of a director&#8217;s duty of loyalty to the corporation or its stockholders.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">The Registrant&#8217;s certificate of incorporation includes such a provision. Expenses incurred by any officer or director in defending any such action, suit or proceeding in advance of its final
      disposition shall be paid by the Registrant upon delivery to the Registrant of an undertaking, by or on behalf of such director or officer, to repay all amounts so advanced if it shall ultimately be determined that such director or officer is not
      entitled to be indemnified by the Registrant.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">As permitted by the Delaware General Corporation Law, the Registrant has entered into and intends to enter into indemnification agreements with each of its directors and executive officers. These
      agreements, among other things, require the Registrant to indemnify each director and officer to the fullest extent permitted by law and advance expenses to each indemnitee in connection with any proceeding in which indemnification is available.</div>
    <div><br>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z40f9efc6c4cc40e6835ecfcf2178299b">

            <tr>
              <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 7.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;">Exemption from Registration Claimed.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Not applicable.</div>
    <div style="text-align: justify; text-indent: 36pt;"> <br>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zc488fec69777401e9d9f9967fe016ea5">

            <tr>
              <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 8.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;">Exhibits.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z5aa2137dc28845a89cf29d6a977af852">

        <tr>
          <td style="width: 13.39%; vertical-align: middle;">
            <div style="text-align: center; font-weight: bold;">Exhibit No.</div>
          </td>
          <td style="width: 86.61%; vertical-align: middle;">
            <div style="text-align: center; font-weight: bold;">Description</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001328/s000911x12_ex3-1.htm">4.1</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div>Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission on October 6, 2015).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036119005071/ex3_1.htm">4.2</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div>Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission on March 18, 2019).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036119005071/ex3_2.htm">4.3</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div>Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed with the Commission on March 18, 2019).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001328/s000911x12_ex3-2.htm">4.4</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div>Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed with the Commission on October 6, 2015).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000156761915001209/s000911x5_ex4-1.htm">4.5</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div>Form of Certificate of Common Stock (incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Pre-Effective Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333- 206416) filed with the Commission on September 21,
              2015).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><a href="ex5_1.htm">5.1</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div>Opinion of DLA Piper LLP (US).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="ex23_1.htm">23.1</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div>Consent of KPMG LLP.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><a href="ex5_1.htm">23.2</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div>Consent of DLA Piper LLP (US) (included in Exhibit 5.1).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="#POWEROFATTORNEY">24</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div>Power of Attorney (contained on the signature page hereto).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div style="text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036119011300/ex10_1.htm">99.1</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(255, 255, 255);">
            <div>PDS Biotechnology Corporation 2019 Inducement Plan (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed with the Commission on June 20, 2019).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 13.39%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="http://www.sec.gov/Archives/edgar/data/1472091/000114036119011300/ex10_2.htm">99.2</a></div>
          </td>
          <td style="width: 86.61%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div>Form of PDS Biotechnology Corporation Stock Option Grant Notice and Stock Option Agreement under the 2019 Inducement Plan (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed with the Commission on June 20,
              2019).</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z565b1ef4d70c415282f595ca03d1ea8a">

            <tr>
              <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 9.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;">Undertakings.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The undersigned Registrant hereby undertakes:</div>
    <div>&#160;</div>
    <div style="text-align: justify; margin-left: 36pt;">(1)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</div>
    <div>&#160;</div>
    <div style="text-align: justify; margin-left: 54pt;">(i)&#160;&#160; To include any prospectus required by Section 10(a)(3) of the Securities Act;</div>
    <div>&#160;</div>
    <div style="text-align: justify; margin-left: 54pt;">(ii)&#160; To reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in
      the aggregate, represent a fundamental change in the information set forth in this Registration Statement; and</div>
    <div>&#160;</div>
    <div style="text-align: justify; margin-left: 54pt;">(iii) To include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any material change to such information in this
      Registration Statement;</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt;"><u>provided</u>, <u>however,</u>&#160; that paragraphs (1)(i) and (1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is
      contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.</div>
    <div>&#160;</div>
    <div style="text-align: justify; margin-left: 36pt;">(2)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the
      securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
    <div>&#160;</div>
    <div style="text-align: justify; margin-left: 36pt;">(3)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
    <div style="text-align: justify; margin-left: 36pt;"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&#8217;s annual report pursuant to Section 13(a) or
      Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a
      new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
    <div style="text-align: justify; text-indent: 36pt;"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or
      otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for
      indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by
      such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
      jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</div>
    <div style="text-align: justify; text-indent: 36pt;"> <br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; font-weight: bold;">SIGNATURE</div>
    <div style="text-indent: 36pt;"><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
      duly caused this Registration Statement with respect to the PDS Biotechnology Corporation 2019 Inducement Plan, to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Berkeley Heights, State of New Jersey, on
      November 14, 2019.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z7545b3e6f3704283a82da980ad7ac22a">

        <tr>
          <td style="width: 50%; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">
            <div style="font-weight: bold;">PDS Biotechnology Corporation</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: middle;">&#160;</td>
          <td style="width: 45%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: middle;">
            <div>By:</div>
          </td>
          <td style="width: 45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Frank Bedu-Addo, Ph.D.</div>
          </td>
        </tr>
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          <td style="width: 50%; vertical-align: middle;">&#160;</td>
          <td style="width: 5%; vertical-align: middle;">
            <div>Name:</div>
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          <td style="width: 45%; vertical-align: middle;">
            <div>Frank Bedu-Addo, Ph.D.</div>
          </td>
        </tr>
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          <td style="width: 50%; vertical-align: middle;">&#160;</td>
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            <div>Title:</div>
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            <div>President and Chief Executive Officer</div>
          </td>
        </tr>

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    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">POWER OF ATTORNEY<a name="POWEROFATTORNEY"><!--Anchor--></a></div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The officers and directors of PDS Biotechnology Corporation whose signatures appear below hereby constitute and appoint Frank Bedu-Addo and Andrew Saik, and each of them, their true and lawful
      attorneys and agents, with full power of substitution, each with power to act alone, to sign and execute on behalf of the undersigned this Registration Statement on Form S-8 with respect to the PDS Biotechnology Corporation 2019 Inducement Plan, and
      any amendment or amendments thereto, and each of the undersigned does hereby ratify and confirm all that each attorney and agent, or his or her substitutes, shall do or cause to be done by virtue hereof.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities on November 14, 2019.</div>
    <div><br>
    </div>
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            <div style="text-align: center; font-weight: bold;">Title</div>
          </td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle;">&#160;</td>
          <td style="width: 55%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Frank Bedu-Addo</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">
            <div style="text-align: center;">President, Chief Executive Officer and Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0);">
            <div>Frank Bedu-Addo</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">
            <div style="text-align: center;">(Principal Executive Officer)</div>
          </td>
        </tr>
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          <td style="width: 45%; vertical-align: middle;">&#160;</td>
          <td style="width: 55%; vertical-align: middle;">&#160;</td>
        </tr>
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          <td style="width: 45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Andrew Saik</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">
            <div style="text-align: center;">Chief Financial Officer and Director</div>
          </td>
        </tr>
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          <td style="width: 45%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0);">
            <div>Andrew Saik</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">
            <div style="text-align: center;">(Principal Financial and Accounting Officer)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle;">&#160;</td>
          <td style="width: 55%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Sir Richard Sykes</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">
            <div style="text-align: center;">Director</div>
          </td>
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          <td style="width: 45%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0);">
            <div>Sir Richard Sykes</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle;">&#160;</td>
          <td style="width: 55%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ De Lyle W. Bloomquist</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">
            <div style="text-align: center;">Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0);">
            <div>De Lyle W. Bloomquist</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle;">&#160;</td>
          <td style="width: 55%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Gregory Freitag</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">
            <div style="text-align: center;">Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0);">
            <div>Gregory Freitag</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle;">&#160;</td>
          <td style="width: 55%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Stephen Glover</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">
            <div style="text-align: center;">Director</div>
          </td>
        </tr>
        <tr>
          <td style="width: 45%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0);">
            <div>Stephen Glover</div>
          </td>
          <td style="width: 55%; vertical-align: middle;">&#160;</td>
        </tr>

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As filed with the Securities and Exchange Commission on November 14, 2019
Registration No. 333-_________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
PDS Biotechnology Corporation
(Exact name of registrant as specified in its charter)
Delaware
26-4231384
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
303A College Road East
Princeton, NJ
08540
(Address of Principal Executive Offices)
(Zip Code)
PDS Biotechnology Corporation 2019 Inducement Plan
(Full title of the plans)
Frank Bedu-Addo
President and Chief Executive Officer
PDS Biotechnology Corporation
303A College Road East
Princeton, NJ 08540
(800) 208-3343
(Name, address and telephone number, including area code, of agent for service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting
      company" in Rule 12b-2 of the Exchange Act.
Large Accelerated filer  ☐
Accelerated filer  ☐
Non-accelerated filer  ☒
Smaller reporting company  ☒
Emerging growth company
☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act.  ☒
CALCULATION OF REGISTRATION FEE
Title of securities to be registered
(1)
Amount to be
registered
(2)
Proposed
maximum
offering price per
share
(3)
Proposed
maximum
aggregate offering
price
(3)
Amount of
registration
fee
Common Stock, Par Value $0.00033
PDS Biotechnology Corporation 2019 Inducement Plan
200,000
$
2.91
$
582,000.00
$
75.55
(1)
The shares to be registered by PDS Biotechnology Corporation (the "
Registrant
") on this Form S-8 Registration Statement represent shares of common stock, par value $0.00033
                  per share ("
Common Stock
"), which are issuable under the PDS Biotechnology Corporation 2019 Inducement Plan, effective as of June 17, 2019 (the "
Inducement Plan
").
(2)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "
Securities Act
"),
                    this Registration Statement shall also cover any additional shares of Common Stock that become issuable under the Inducement Plan by reason of any stock dividend, stock split, recapitalization or other similar transaction effected
                    without the Registrant's receipt of consideration that increases the number of the outstanding shares of the Registrant's Common Stock
.
(3)
Computed in accordance with Rules 457(c) and (h) under the Securities Act, solely for the purpose of calculating the registration fee, based on the average of the high and low prices of the Registrant's Common Stock as reported on the
                  Nasdaq Capital Market on November 8, 2019.
Proposed sales to take place as soon after the effective date of the Registration Statement
as awards under the above-named plan are granted, exercised and/or distributed.
PART I
Information Required in the Section 10(a) Prospectus
Item 1.
Plan Information.
The documents containing the information specified in Part I will be delivered in accordance with Form S-8 and Rule 428(b)(1) of the Securities Act. Such documents are not required to be, and are
      not, filed with the Securities and Exchange Commission (the "
Commission
"), either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424
      under the Securities Act. These documents, and the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Part II of this Form S-8, taken together, constitute a prospectus that meets the requirements of Section 10(a)
      of the Securities Act.
Item 2.
Registrant Information and Employee Plan Annual Information
.
The written statement required by Item 2 is included in documents sent or given to participants in the Inducement Plan covered by this Registration Statement pursuant to Rule 428(b)(1) of the
      Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The Registrant hereby incorporates by reference in this Registration Statement the following documents:
(a)
The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed
                      with the Commission on February 21, 2019 pursuant to Section 13(a) of the Securities Exchange Act of 1934, as amended (the "
Exchange Act
"), which contains the Registrant's audited financial statements for the latest fiscal year for which such statements have been filed
;
(b)
All other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Registrant's Annual Report on Form 10-K referred to in (a) above; and
(c)
The description of the Registrant's Common Stock, contained in its registration
                      statement on Form 8-A, which was filed with the Commission on September 25, 2015
.
All reports and definitive proxy or information statements filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this Registration Statement and prior to the filing of
      a post-effective amendment which indicates that all securities offered hereby have been sold or which de-registers all securities then remaining unsold shall be deemed to be incorporated by reference into this Registration Statement and to be a part
      hereof from the date of filing of such documents.  Unless expressly incorporated into this Registration Statement, a report furnished but not filed on Form 8-K under the Exchange Act shall not be incorporated by reference into this Registration
      Statement.  Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein
      or in any subsequently filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement.  Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to
      constitute a part of this Registration Statement.
Item 4.
Description of Securities.
Not applicable.
Item 5.
Interests of Named Experts and Counsel.
Not applicable.
Item 6.
Indemnification of Directors and Officers.
The Registrant is incorporated under the laws of the State of Delaware. Section 145 of the Delaware General Corporation Law provides that a Delaware corporation may indemnify any persons who are, or
      are threatened to be made, parties to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of such corporation), by reason of the fact that
      such person was an officer, director, employee or agent of such corporation, or is or was serving at the request of such person as an officer, director, employee or agent of another corporation or enterprise. The indemnity may include expenses
      (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with such action, suit or proceeding, provided that such person acted in good faith and in a manner he or she
      reasonably believed to be in or not opposed to the corporation's best interests and, with respect to any criminal action or proceeding, had no reasonable cause to believe that his or her conduct was illegal. A Delaware corporation may indemnify any
      persons who are, or are threatened to be made, a party to any threatened, pending or completed action or suit by or in the right of the corporation by reason of the fact that such person was a director, officer, employee or agent of such corporation,
      or is or was serving at the request of such corporation as a director, officer, employee or agent of another corporation or enterprise. The indemnity may include expenses (including attorneys' fees) actually and reasonably incurred by such person in
      connection with the defense or settlement of such action or suit, provided that such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation's best interests except that no indemnification
      is permitted without judicial approval if the officer or director is adjudged to be liable to the corporation. Where an officer or director is successful on the merits or otherwise in the defense of any action referred to above, the corporation must
      indemnify him or her against the expenses which such officer or director has actually and reasonably incurred. The Registrant's certificate of incorporation and bylaws provide for the indemnification of its directors and officers to the fullest
      extent permitted under the Delaware General Corporation Law.
Section 102(b)(7) of the Delaware General Corporation Law permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable to the
      corporation or its stockholders for monetary damages for breach of fiduciary duties as a director, except for liability for any:
•
transaction from which the director derives an improper personal benefit;
•
act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;
•
unlawful payment of dividends or redemption of shares; or
•
breach of a director's duty of loyalty to the corporation or its stockholders.
The Registrant's certificate of incorporation includes such a provision. Expenses incurred by any officer or director in defending any such action, suit or proceeding in advance of its final
      disposition shall be paid by the Registrant upon delivery to the Registrant of an undertaking, by or on behalf of such director or officer, to repay all amounts so advanced if it shall ultimately be determined that such director or officer is not
      entitled to be indemnified by the Registrant.
As permitted by the Delaware General Corporation Law, the Registrant has entered into and intends to enter into indemnification agreements with each of its directors and executive officers. These
      agreements, among other things, require the Registrant to indemnify each director and officer to the fullest extent permitted by law and advance expenses to each indemnitee in connection with any proceeding in which indemnification is available.
Item 7.
Exemption from Registration Claimed.
Not applicable.
Item 8.
Exhibits.
Exhibit No.
Description
4.1
Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission on October 6, 2015).
4.2
Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission on March 18, 2019).
4.3
Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed with the Commission on March 18, 2019).
4.4
Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed with the Commission on October 6, 2015).
4.5
Form of Certificate of Common Stock (incorporated by reference to Exhibit 4.1 to the Registrant's Pre-Effective Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333- 206416) filed with the Commission on September 21,
              2015).
5.1
Opinion of DLA Piper LLP (US).
23.1
Consent of KPMG LLP.
23.2
Consent of DLA Piper LLP (US) (included in Exhibit 5.1).
24
Power of Attorney (contained on the signature page hereto).
99.1
PDS Biotechnology Corporation 2019 Inducement Plan (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed with the Commission on June 20, 2019).
99.2
Form of PDS Biotechnology Corporation Stock Option Grant Notice and Stock Option Agreement under the 2019 Inducement Plan (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed with the Commission on June 20,
              2019).
Item 9.
Undertakings.
The undersigned Registrant hereby undertakes:
(1)         To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)   To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)  To reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in
      the aggregate, represent a fundamental change in the information set forth in this Registration Statement; and
(iii) To include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any material change to such information in this
      Registration Statement;
provided
,
however,
that paragraphs (1)(i) and (1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is
      contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
(2)         That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the
      securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(3)         To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or
      Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a
      new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or
      otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for
      indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by
      such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate
      jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURE
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has
      duly caused this Registration Statement with respect to the PDS Biotechnology Corporation 2019 Inducement Plan, to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Berkeley Heights, State of New Jersey, on
      November 14, 2019.
PDS Biotechnology Corporation
By:
/s/ Frank Bedu-Addo, Ph.D.
Name:
Frank Bedu-Addo, Ph.D.
Title:
President and Chief Executive Officer
POWER OF ATTORNEY
The officers and directors of PDS Biotechnology Corporation whose signatures appear below hereby constitute and appoint Frank Bedu-Addo and Andrew Saik, and each of them, their true and lawful
      attorneys and agents, with full power of substitution, each with power to act alone, to sign and execute on behalf of the undersigned this Registration Statement on Form S-8 with respect to the PDS Biotechnology Corporation 2019 Inducement Plan, and
      any amendment or amendments thereto, and each of the undersigned does hereby ratify and confirm all that each attorney and agent, or his or her substitutes, shall do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities on November 14, 2019.
Signature
Title
/s/ Frank Bedu-Addo
President, Chief Executive Officer and Director
Frank Bedu-Addo
(Principal Executive Officer)
/s/ Andrew Saik
Chief Financial Officer and Director
Andrew Saik
(Principal Financial and Accounting Officer)
/s/ Sir Richard Sykes
Director
Sir Richard Sykes
/s/ De Lyle W. Bloomquist
Director
De Lyle W. Bloomquist
/s/ Gregory Freitag
Director
Gregory Freitag
/s/ Stephen Glover
Director
Stephen Glover