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    <div style="text-align: center;">As filed with the Securities and Exchange Commission on November 15, 2021 </div>
    <div>
      <div style="text-align: right; color: rgb(0, 0, 0);">Registration No. 333-_________</div>
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        <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <font style="font-size: 14pt;"> </font>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">UNDER</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;">PDS Biotechnology Corporation</div>
      <div style="text-align: center; color: rgb(0, 0, 0);">(Exact name of registrant as specified in its charter)</div>
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              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
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            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">26-4231384</div>
            </td>
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            <td style="width: 49.01%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0);">(State or other jurisdiction of incorporation or organization)</div>
            </td>
            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0);">(I.R.S. Employer Identification No.)</div>
            </td>
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              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Hlk60999753"></a>25B Vreeland Road, Suite 300</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Florham Park, NJ</div>
            </td>
            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">07932</div>
            </td>
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            <td style="width: 49.01%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0);">(Address of Principal Executive Offices)</div>
            </td>
            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0);">(Zip Code)</div>
            </td>
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      </table>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">PDS Biotechnology Corporation 2019 Inducement Plan, as amended</div>
      <div style="text-align: center; color: rgb(0, 0, 0);">&#160;(Full title of the plans)</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Frank Bedu-Addo</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">President and Chief Executive Officer</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">PDS Biotechnology Corporation</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">25B Vreeland Road, Suite 300</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Florham Park, NJ 07932</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(800) 208-3343</div>
      <div style="text-align: center; color: rgb(0, 0, 0);">(Name, address and telephone number, including area code, of agent for service)</div>
      <div><br>
      </div>
      <div style="color: rgb(0, 0, 0);">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &#8220;large accelerated filer,&#8221;
        &#8220;accelerated filer&#8221; and &#8220;smaller reporting company&#8221; in Rule 12b-2 of the Exchange Act.</div>
      <div style="color: rgb(0, 0, 0);"> <br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z23eecb58a6c04012b536406242ff05b3">

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            <td style="width: 15%; vertical-align: middle;">&#160;</td>
            <td style="width: 35%; vertical-align: middle;">
              <div style="color: rgb(0, 0, 0);">Large Accelerated filer &#9744;</div>
            </td>
            <td style="width: 50%; vertical-align: middle;">
              <div style="color: rgb(0, 0, 0);">Accelerated filer &#9744;</div>
            </td>
          </tr>
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            <td style="width: 15%; vertical-align: top;">&#160;</td>
            <td style="width: 35%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Non-accelerated filer &#9746;</div>
            </td>
            <td style="width: 50%; vertical-align: middle;">
              <div style="color: rgb(0, 0, 0);">Smaller reporting company &#9746;</div>
            </td>
          </tr>
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            <td style="width: 15%; vertical-align: top;">&#160;</td>
            <td style="width: 35%; vertical-align: top;">&#160;</td>
            <td style="width: 50%; vertical-align: middle;">
              <div style="color: rgb(0, 0, 0);">Emerging growth company &#9744;</div>
            </td>
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      </table>
      <div> <br>
      </div>
      <div style="color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
        Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
      <div style="color: rgb(0, 0, 0);"> <br>
      </div>
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      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000; width: 100%;" id="z2e67fefc854f4c549f5f563849ea274d" class="cfttable">

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              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif;"><font style="font-weight: bold; font-family: 'Times New Roman';">Title of securities to be registered</font><font style="font-family: 'Times New Roman';"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></font></div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: middle;" colspan="2">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Amount to be</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif;"><font style="font-weight: bold; font-family: 'Times New Roman';">registered</font><font style="font-family: 'Times New Roman';"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></font></div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: middle;" colspan="2">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Proposed</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">maximum</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">offering price per</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif;"><font style="font-weight: bold; font-family: 'Times New Roman';">share</font><font style="font-family: 'Times New Roman';"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></font></div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: middle;" colspan="2">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Proposed</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">maximum</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">aggregate offering</div>
              <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif;"><font style="font-weight: bold; font-family: 'Times New Roman';">price</font><font style="font-family: 'Times New Roman';"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></font></div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: middle;" colspan="2">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Amount of</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">registration</div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">fee</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
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            <td valign="bottom" style="vertical-align: middle; width: 52%; background-color: #CCEEFF;">
              <div style="color: rgb(0, 0, 0);">Common Stock, par value $0.00033 per share</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div style="color: rgb(0, 0, 0);">300,000</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">
              <div style="color: rgb(0, 0, 0);"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup>&#160;</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div style="color: rgb(0, 0, 0);">$</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div style="color: rgb(0, 0, 0);">11.07</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div style="color: rgb(0, 0, 0);">$</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div style="color: rgb(0, 0, 0);">3,321,000.00</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftguttercell">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftcurrcell">
              <div style="color: rgb(0, 0, 0);">$</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1" class="cftnumcell">
              <div style="color: rgb(0, 0, 0);">307.86</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1" class="cftfncell">&#160;</td>
          </tr>

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      <div> <br>
      </div>
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            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">The shares registered by PDS Biotechnology Corporation (the &#8220;<font style="font-weight: bold; font-style: italic;">Registrant</font>&#8221;) on this Form S-8 Registration represent shares of common stock, par value
                $0.00033 per share (&#8220;<font style="font-weight: bold; font-style: italic;">Common Stock</font>&#8221;), which are issuable under the PDS Biotechnology Corporation 2019 Inducement Plan, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Inducement Plan</font>&#8221;).</div>
            </td>
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      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zc4897dcc9d504212856c4943906632fc">

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            </td>
            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Securities Act</font>&#8221;), this Registration Statement shall also cover any
                additional shares of Common Stock which become issuable under the Inducement Plan by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the Registrant&#8217;s receipt of consideration that
                increases the number of the outstanding shares of the Registrant&#8217;s Common Stock.</div>
            </td>
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      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z26104b8505e745fc881937f1899892a2">

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            </td>
            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Calculated solely for purposes of this offering under Rule 457(c) and Rule 457(h) of the Securities Act, on the basis of the average of the high and low prices per share of the Registrant&#8217;s Common Stock on
                November 9, 2021 as reported by the Nasdaq Capital Market.</div>
            </td>
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            </td>
            <td style="width: 18pt; vertical-align: top; color: rgb(0, 0, 0);">(4)</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Represents an increase in the number of shares of Common Stock reserved for issuance under the Inducement Plan, pursuant to an amendment to the Inducement Plan effective as of December 8, 2020.</div>
            </td>
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      <div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Part II</div>
      </div>
      <div>
        <div><br>
        </div>
      </div>
      <div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Information Required In The Registration Statement</div>
      </div>
      <div>
        <div><br>
        </div>
      </div>
      <div>
        <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"><font style="color: rgb(0, 0, 0); font-family: 'Times New Roman';">This Registration Statement relates to the registration of an additional 300,000
            shares (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Shares</font><font style="color: rgb(0, 0, 0); font-family: 'Times New Roman';">&#8221;) of the Registrant&#8217;s Common Stock.
            The Shares are securities of the same class and relate to the same employee benefit plan, the PDS Biotechnology Corporation 2019 Inducement Plan, which was amended effective as of December 8, 2020 (in the form attached hereto as Exhibit 99.1)
            (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: rgb(0, 0, 0); font-family: 'Times New Roman';">Inducement Plan</font><font style="color: rgb(0, 0, 0); font-family: 'Times New Roman';">&#8221;), as those registered pursuant to
            the Registrant&#8217;s registration statement on Form S-8, previously filed with the Securities and Exchange Commission on </font><font style="font-family: 'Times New Roman';"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036119020567/0001140361-19-020567-index.htm">November 14, 2019 (Registration No. 333-234693).</a> In accordance with General Instruction E of Form S-8, the contents of the
            Registrant&#8217;s registration statement on Form S-8 filed with the Securities and Exchange Commission on <a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036119020567/0001140361-19-020567-index.htm">November 14, 2019 (Registration
              No. 333-234693)</a><font style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036119020567/0001140361-19-020567-index.htm"> </a>is incorporated herein by reference (solely to the extent the contents of such
              registration statement relate to the Inducement Plan) and the information required by Part II is omitted, except as supplemented by the information set forth below.</font></font></div>
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            <td style="width: 54pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 8.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibits.</div>
            </td>
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              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Exhibit No.</div>
            </td>
            <td style="width: 90%; vertical-align: middle;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Description</div>
            </td>
          </tr>
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            <td style="width: 10%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000156761915001328/s000911x12_ex3-1.htm">4.1</a></div>
            </td>
            <td style="width: 90%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission on October 6, 2015).</div>
            </td>
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            <td style="width: 10%; vertical-align: middle;">
              <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036119005071/ex3_1.htm">4.2</a></div>
            </td>
            <td style="width: 90%; vertical-align: middle;">
              <div style="color: rgb(0, 0, 0);">Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission
                on March 18, 2019).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036119005071/ex3_2.htm">4.3</a></div>
            </td>
            <td style="width: 90%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed with the Commission
                on March 18, 2019).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: middle;">
              <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000156761915001328/s000911x12_ex3-2.htm">4.4</a></div>
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              <div style="color: rgb(0, 0, 0);">Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed with the Commission on October 6, 2015).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000156761915001209/s000911x5_ex4-1.htm">4.5</a></div>
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            <td style="width: 90%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Form of Certificate of Common Stock (incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Pre-Effective Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333- 206416) filed with the
                Commission on September 21, 2015).</div>
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            <td style="width: 10%; vertical-align: middle;">
              <div style="text-align: center;"><a href="brhc10030771_ex5-1.htm">5.1*</a></div>
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              <div style="color: rgb(0, 0, 0);">Opinion of DLA Piper LLP (US).</div>
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          <tr>
            <td style="width: 10%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;"><a href="brhc10030771_ex23-1.htm">23.1*</a></div>
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            <td style="width: 90%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Consent of KPMG LLP.</div>
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          </tr>
          <tr>
            <td style="width: 10%; vertical-align: middle;">
              <div style="text-align: center;"><a href="brhc10030771_ex5-1.htm">23.2*</a></div>
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              <div style="color: rgb(0, 0, 0);">Consent of DLA Piper LLP (US) (included in Exhibit 5.1).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;"><a href="#POA">24</a></div>
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              <div style="color: rgb(0, 0, 0);">Power of Attorney (contained on the signature page hereto).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: middle;">
              <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1472091/000114036120027857/brhc10017772_ex10-2.htm">99.1</a></div>
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            <td style="width: 90%; vertical-align: middle;">
              <div style="color: rgb(0, 0, 0);">PDS Biotechnology Corporation 2019 Inducement Plan, as amended (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed with the Commission on December 9, 2020).</div>
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          <tr>
            <td style="width: 10%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">*</div>
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            <td style="width: 90%; vertical-align: middle; background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Filed herewith</div>
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      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing
        on Form S-8 and has duly caused this Registration Statement with respect to the PDS Biotechnology Corporation 2019 Inducement Plan, as amended, to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Florham Park,
        State of New Jersey, on November 15, 2021.</div>
      <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);"> <br>
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          <tr>
            <td style="width: 49.59%; vertical-align: middle;">&#160;</td>
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              <div style="color: rgb(0, 0, 0); font-weight: bold;">PDS Biotechnology Corporation</div>
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            <td style="width: 49.59%; vertical-align: middle;">&#160;</td>
            <td style="width: 5%; vertical-align: middle;">&#160;</td>
            <td style="width: 44.59%; vertical-align: middle;">&#160;</td>
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            <td style="width: 49.59%; vertical-align: middle;">&#160;</td>
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              <div style="color: rgb(0, 0, 0);">By:</div>
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            <td style="width: 44.59%; vertical-align: middle; border-bottom: #000000 2px solid;">
              <div style="color: rgb(0, 0, 0);">/s/ Frank Bedu-Addo</div>
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            <td style="width: 49.59%; vertical-align: middle;">&#160;</td>
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              <div style="color: rgb(0, 0, 0);">Frank Bedu-Addo</div>
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            <td style="width: 49.59%; vertical-align: middle;">&#160;</td>
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      <div style="text-align: center;"><a name="POWEROFATTORNEY"></a>
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        <div style="color: rgb(0, 0, 0); font-weight: bold;"><a name="POA"><!--Anchor--></a>POWER OF ATTORNEY</div>
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        <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">The officers and directors of PDS Biotechnology Corporation whose signatures appear below hereby constitute and appoint Frank Bedu-Addo and Matthew Hill, and each of them,
          their true and lawful attorneys and agents, with full power of substitution, each with power to act alone, to sign and execute on behalf of the undersigned this Registration Statement on Form S-8 with respect to the PDS Biotechnology Corporation
          2019 Inducement Plan, as amended, and any amendment or amendments thereto, and each of the undersigned does hereby ratify and confirm all that each attorney and agent, or his or her substitutes, shall do or cause to be done by virtue hereof.</div>
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        <div style="text-align: justify; text-indent: 36pt; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.</div>
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              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
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              <td style="width: 28%; vertical-align: middle;">&#160;</td>
              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">&#160;</td>
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              <td style="width: 28%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Frank Bedu-Addo</td>
              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">
                <div style="text-align: center; color: rgb(0, 0, 0);">President, Chief Executive Officer and Director</div>
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              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
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                <div style="text-align: center; color: rgb(0, 0, 0);">November 15, 2021</div>
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            <tr>
              <td style="width: 28%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);">Frank Bedu-Addo</div>
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              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">&#160;</td>
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              <td style="width: 28%; vertical-align: middle;">&#160;</td>
              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">&#160;</td>
              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">&#160;</td>
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              <td style="width: 28%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Matthew Hill</td>
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              <td style="width: 27.64%; vertical-align: middle;">
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              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">&#160;</td>
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              <td style="width: 28%; vertical-align: middle;">&#160;</td>
              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">&#160;</td>
              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">&#160;</td>
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              <td style="width: 28%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Stephen Glover</td>
              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
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              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">
                <div style="text-align: center; color: rgb(0, 0, 0);">November 15, 2021</div>
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            <tr>
              <td style="width: 28%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);">Stephen Glover</div>
              </td>
              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">&#160;</td>
              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">&#160;</td>
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              <td style="width: 28%; vertical-align: middle;">&#160;</td>
              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">&#160;</td>
              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">&#160;</td>
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              <td style="width: 28%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Kamil Ali-Jackson</td>
              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
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              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">
                <div style="text-align: center; color: rgb(0, 0, 0);">November 15, 2021</div>
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              <td style="width: 28%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);">Kamil Ali-Jackson</div>
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              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">&#160;</td>
              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">&#160;</td>
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              <td style="width: 28%; vertical-align: middle;">&#160;</td>
              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">&#160;</td>
              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">&#160;</td>
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              <td style="width: 40%; vertical-align: middle;">
                <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
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              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">
                <div style="text-align: center; color: rgb(0, 0, 0);">November 15, 2021</div>
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              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">&#160;</td>
              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: middle;">&#160;</td>
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              <td style="width: 28%; vertical-align: middle;">&#160;</td>
              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: bottom;">&#160;</td>
              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: bottom;">&#160;</td>
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              <td style="width: 2%; vertical-align: middle;">&#160;</td>
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              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: bottom;">
                <div style="text-align: center; color: rgb(0, 0, 0);">November 15, 2021</div>
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              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: middle;">&#160;</td>
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              <td style="width: 2%; vertical-align: middle;">&#160;</td>
              <td style="width: 40%; vertical-align: bottom;">
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              <td style="width: 2.36%; vertical-align: middle;">&#160;</td>
              <td style="width: 27.64%; vertical-align: bottom;">
                <div style="text-align: center; color: rgb(0, 0, 0);">November 15, 2021</div>
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{"company-data": {"conformed-name": "PDS Biotechnology Corp", "cik": "0001472091", "assigned-sic": "2834", "irs-number": "264231384", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-261072", "film-number": "211410378"}, "business-address": {"street1": "25B VREELAND ROAD", "street2": "SUITE 300", "city": "FLORHAM PARK", "state": "NJ", "zip": "07932", "phone": "800-208-3343"}, "mail-address": {"street1": "25B VREELAND ROAD", "street2": "SUITE 300", "city": "FLORHAM PARK", "state": "NJ", "zip": "07932"}, "former-company": {"former-conformed-name": "Edge Therapeutics, Inc.", "date-changed": "20090911"}}
As filed with the Securities and Exchange Commission on November 15, 2021
Registration No. 333-_________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
PDS Biotechnology Corporation
(Exact name of registrant as specified in its charter)
Delaware
26-4231384
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
25B Vreeland Road, Suite 300
Florham Park, NJ
07932
(Address of Principal Executive Offices)
(Zip Code)
PDS Biotechnology Corporation 2019 Inducement Plan, as amended
(Full title of the plans)
Frank Bedu-Addo
President and Chief Executive Officer
PDS Biotechnology Corporation
25B Vreeland Road, Suite 300
Florham Park, NJ 07932
(800) 208-3343
(Name, address and telephone number, including area code, of agent for service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer,"
        "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act.
Large Accelerated filer ☐
Accelerated filer ☐
Non-accelerated filer ☒
Smaller reporting company ☒
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
        Section 7(a)(2)(B) of the Securities Act. ☐
CALCULATION OF REGISTRATION FEE
Title of securities to be registered
(1)
Amount to be
registered
(2)
Proposed
maximum
offering price per
share
(3)
Proposed
maximum
aggregate offering
price
(3)
Amount of
registration
fee
Common Stock, par value $0.00033 per share
300,000
(4)
$
11.07
$
3,321,000.00
$
307.86
(1)
The shares registered by PDS Biotechnology Corporation (the "
Registrant
") on this Form S-8 Registration represent shares of common stock, par value
                $0.00033 per share ("
Common Stock
"), which are issuable under the PDS Biotechnology Corporation 2019 Inducement Plan, as amended (the "
Inducement Plan
").
(2)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "
Securities Act
"), this Registration Statement shall also cover any
                additional shares of Common Stock which become issuable under the Inducement Plan by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the Registrant's receipt of consideration that
                increases the number of the outstanding shares of the Registrant's Common Stock.
(3)
Calculated solely for purposes of this offering under Rule 457(c) and Rule 457(h) of the Securities Act, on the basis of the average of the high and low prices per share of the Registrant's Common Stock on
                November 9, 2021 as reported by the Nasdaq Capital Market.
(4)
Represents an increase in the number of shares of Common Stock reserved for issuance under the Inducement Plan, pursuant to an amendment to the Inducement Plan effective as of December 8, 2020.
Part II
Information Required In The Registration Statement
This Registration Statement relates to the registration of an additional 300,000
            shares (the "
Shares
") of the Registrant's Common Stock.
            The Shares are securities of the same class and relate to the same employee benefit plan, the PDS Biotechnology Corporation 2019 Inducement Plan, which was amended effective as of December 8, 2020 (in the form attached hereto as Exhibit 99.1)
            (the "
Inducement Plan
"), as those registered pursuant to
            the Registrant's registration statement on Form S-8, previously filed with the Securities and Exchange Commission on
November 14, 2019 (Registration No. 333-234693).
In accordance with General Instruction E of Form S-8, the contents of the
            Registrant's registration statement on Form S-8 filed with the Securities and Exchange Commission on
November 14, 2019 (Registration
              No. 333-234693)
is incorporated herein by reference (solely to the extent the contents of such
              registration statement relate to the Inducement Plan) and the information required by Part II is omitted, except as supplemented by the information set forth below.
Item 8.
Exhibits.
Exhibit No.
Description
4.1
Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission on October 6, 2015).
4.2
Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed with the Commission
                on March 18, 2019).
4.3
Certificate of Amendment of the Eighth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed with the Commission
                on March 18, 2019).
4.4
Second Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Current Report on Form 8-K filed with the Commission on October 6, 2015).
4.5
Form of Certificate of Common Stock (incorporated by reference to Exhibit 4.1 to the Registrant's Pre-Effective Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333- 206416) filed with the
                Commission on September 21, 2015).
5.1*
Opinion of DLA Piper LLP (US).
23.1*
Consent of KPMG LLP.
23.2*
Consent of DLA Piper LLP (US) (included in Exhibit 5.1).
24
Power of Attorney (contained on the signature page hereto).
99.1
PDS Biotechnology Corporation 2019 Inducement Plan, as amended (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed with the Commission on December 9, 2020).
*
Filed herewith
SIGNATURE
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing
        on Form S-8 and has duly caused this Registration Statement with respect to the PDS Biotechnology Corporation 2019 Inducement Plan, as amended, to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Florham Park,
        State of New Jersey, on November 15, 2021.
PDS Biotechnology Corporation
By:
/s/ Frank Bedu-Addo
Name:
Frank Bedu-Addo
Title:
President and Chief Executive Officer
POWER OF ATTORNEY
The officers and directors of PDS Biotechnology Corporation whose signatures appear below hereby constitute and appoint Frank Bedu-Addo and Matthew Hill, and each of them,
          their true and lawful attorneys and agents, with full power of substitution, each with power to act alone, to sign and execute on behalf of the undersigned this Registration Statement on Form S-8 with respect to the PDS Biotechnology Corporation
          2019 Inducement Plan, as amended, and any amendment or amendments thereto, and each of the undersigned does hereby ratify and confirm all that each attorney and agent, or his or her substitutes, shall do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.
Signature
Title
Date
/s/ Frank Bedu-Addo
President, Chief Executive Officer and Director
November 15, 2021
Frank Bedu-Addo
(Principal Executive Officer)
/s/ Matthew Hill
Chief Financial Officer
November 15, 2021
Matthew Hill
(Principal Financial and Accounting Officer)
/s/ Stephen Glover
Director
November 15, 2021
Stephen Glover
/s/ Kamil Ali-Jackson
Director
November 15, 2021
Kamil Ali-Jackson
/s/ Otis W. Brawley
Director
November 15, 2021
Otis W. Brawley
/s/ Gregory Freitag
Director
November 15, 2021
Gregory Freitag
/s/ Ilian Iliev
Director
November 15, 2021
Ilian Iliev
/s/ Sir Richard Sykes
Director
November 15, 2021
Sir Richard Sykes