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    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">As filed with the Securities and Exchange Commission on June 11, 2021</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 18pt; font-weight: bold;">
      <div style="text-align: right;"> <font style="font-weight: bold; font-size: 10pt;">Registration No. 333-</font>
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    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 18pt; font-weight: bold;"> <font style="font-size: 10pt;"> <font style="font-size: 14pt;">UNITED STATES</font></font></div>
    <font style="font-size: 14pt;"></font><font style="font-size: 14pt;"></font>
    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold;"> <font style="font-size: 10pt;"><br>
      </font> </div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 14pt; font-weight: bold;">
      <hr style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000;" align="center" noshade="noshade"><font style="font-size: 10pt;">&#160;</font></div>
    <div style="font-family: 'Times New Roman'; font-weight: bold; text-align: center;"> <font style="font-size: 18pt;">FORM S-8</font><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-style: italic; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-size: 14pt; font-style: italic; font-weight: bold;">
      <hr style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000;" align="center" noshade="noshade"> </div>
    <div style="text-align: center; margin-top: 3pt; font-family: 'Times New Roman'; font-size: 24pt; font-weight: bold;">&#160;Infinity Pharmaceuticals, Inc.</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">(Exact Name of Registrant as Specified in Its Charter)</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">
      <hr style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000;" align="center" noshade="noshade"> </div>
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            <div style="text-align: center; font-weight: bold;">Delaware</div>
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          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 49%; vertical-align: top; font-family: 'Times New Roman';">
            <div style="text-align: center; font-weight: bold;">33-0655706</div>
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            <div style="text-align: center; font-weight: bold;">(State or Other Jurisdiction of</div>
            <div style="text-align: center; font-weight: bold;"> Incorporation or Organization)</div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 49%; vertical-align: top; font-family: 'Times New Roman';">
            <div style="text-align: center; font-weight: bold;">(I.R.S. Employer</div>
            <div style="text-align: center; font-weight: bold;"> Identification No.)</div>
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      </font> </div>
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            <div style="text-align: center; font-weight: bold;">1100 Massachusetts Avenue, Floor 4</div>
            <div style="text-align: center; font-weight: bold;"> Cambridge, Massachusetts</div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
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            <div style="font-weight: bold;">02138</div>
          </td>
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            <div style="text-align: center; font-weight: bold;">(Address of Principal Executive Offices)</div>
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          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
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            <div style="text-align: center; font-weight: bold;">(Zip Code)</div>
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    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Infinity Pharmaceuticals, Inc. 2013 Employee Stock Purchase Plan, as amended</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">(Full Title of the Plan)</div>
    <div style="font-family: 'Times New Roman';"><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Seth A. Tasker, Esq.</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Senior Vice President, Chief Business Officer</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Infinity Pharmaceuticals, Inc.</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">1100 Massachusetts Avenue, Floor 4</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Cambridge, Massachusetts 02138</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">(Name and Address of Agent For Service)</div>
    <div style="text-align: center; margin-top: 3pt; font-family: 'Times New Roman'; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; margin-top: 3pt; font-family: 'Times New Roman'; font-weight: bold;">(617) 453-1000</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">(Telephone Number, Including Area Code, of Agent For Service)</div>
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    </div>
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      <hr style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000;" align="center" noshade="noshade"> </div>
    <div style="text-align: center; margin-top: 3pt; font-family: 'Times New Roman'; font-style: italic; font-weight: bold;"> With copies to:</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Cynthia T. Mazareas, Esq.</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Wilmer Cutler Pickering Hale and Dorr LLP</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">60 State Street</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Boston, MA 02109</div>
    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">Telephone: (617) 526-6000</div>
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    </div>
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    <div style="font-family: 'Times New Roman';">&#160; </div>
    <div style="font-family: 'Times New Roman';">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of
      &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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          <td style="width: 25%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Large accelerated filer</div>
          </td>
          <td style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">
            <div>&#9744;</div>
          </td>
          <td style="width: 46%; vertical-align: top; font-family: 'Times New Roman';" colspan="1">&#160;</td>
          <td style="width: 25%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Accelerated filer</div>
          </td>
          <td style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">
            <div>&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Non-accelerated filer</div>
          </td>
          <td style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">
            <div>&#9746;</div>
          </td>
          <td style="width: 46%; vertical-align: top; font-family: 'Times New Roman';" colspan="1">&#160;</td>
          <td style="width: 25%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Smaller reporting company</div>
          </td>
          <td style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">
            <div>&#9746;</div>
          </td>
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          <td style="width: 25%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 46%; vertical-align: top; font-family: 'Times New Roman';" colspan="1">&#160;</td>
          <td style="width: 25%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Emerging growth company</div>
          </td>
          <td style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">
            <div>&#9744;</div>
          </td>
        </tr>

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    <div style="margin-top: 3pt; font-family: 'Times New Roman';"> <br>
    </div>
    <div style="font-family: 'Times New Roman';">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided
      pursuant to Section 7(a)(2)(B) of the Securities Act.&#160; &#9744;</div>
    <div style="font-family: 'Times New Roman';"> <br>
    </div>
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  <div style="text-align: center;"> <font style="font-weight: bold; font-family: 'Times New Roman';">CALCULATION OF REGISTRATION FEE </font></div>
  <font style="font-family: 'Times New Roman';">&#160;</font>
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            <div style="font-weight: bold;">Title of Securities</div>
            <div style="font-weight: bold;"> to be Registered</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; font-family: 'Times New Roman'; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="vertical-align: bottom; font-family: 'Times New Roman'; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); width: 12%; border-top: 2px solid rgb(0, 0, 0);" nowrap="nowrap">
            <div style="font-weight: bold;">Amount</div>
            <div style="font-weight: bold;"> to be</div>
            <div style="font-weight: bold;"> Registered(1)</div>
          </td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td style="vertical-align: top; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); width: 12%;" nowrap="nowrap" valign="bottom">
            <div style="text-align: center; font-weight: bold;">Proposed </div>
            <div style="text-align: center; font-weight: bold;">Maximum</div>
            <div style="text-align: center; font-weight: bold;"> Offering Price</div>
            <div style="text-align: center; font-weight: bold;"> Per Share</div>
          </td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; border-top: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td style="vertical-align: top; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); width: 12%;" nowrap="nowrap" valign="bottom">
            <div style="text-align: center; font-weight: bold;">Proposed </div>
            <div style="text-align: center; font-weight: bold;">Maximum </div>
            <div style="text-align: center; font-weight: bold;">Aggregate</div>
            <div style="text-align: center; font-weight: bold;"> Offering Price</div>
          </td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; border-top: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td style="vertical-align: bottom; font-family: 'Times New Roman'; text-align: center; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); width: 12%;" nowrap="nowrap">
            <div style="font-weight: bold;">Amount of</div>
            <div style="font-weight: bold;"> Registration Fee</div>
          </td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 1%; border-top: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
        </tr>
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          <td style="vertical-align: top; font-family: 'Times New Roman'; width: 45%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">
            <div style="text-align: center;">Common Stock, $0.001 par value per share</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; font-family: 'Times New Roman'; width: 1%; background-color: rgb(204, 238, 255); text-align: center; border-left: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
          <td style="vertical-align: bottom; font-family: 'Times New Roman'; width: 12%; background-color: rgb(204, 238, 255); text-align: center; border-bottom: 4px double rgb(0, 0, 0);">
            <div>550,000 shares(2)</div>
          </td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-left: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td rowspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; width: 12%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">
            <div style="text-align: center;">$3.42(3)</div>
          </td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
            <div><br>
            </div>
          </td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-left: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td rowspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; width: 12%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">
            <div style="text-align: center;">$1,881,000(3)</div>
          </td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
            <div><br>
            </div>
          </td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-left: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td rowspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; width: 12%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">
            <div style="text-align: center;">$205.22</div>
          </td>
          <td colspan="1" style="font-family: 'Times New Roman'; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
        </tr>

    </table>
    <div style="font-family: 'Times New Roman';">&#160;</div>
    <div>
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              <div style="font-family: 'Times New Roman';">(1)</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="font-family: 'Times New Roman';">In accordance with Rule 416 under the Securities Act of 1933, as amended, this registration statement shall be deemed to cover any additional securities that may from time to time be offered or
                issued to prevent dilution resulting from stock splits, stock dividends or similar transactions.</div>
            </td>
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              <div style="font-family: 'Times New Roman';">(2)</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="font-family: 'Times New Roman';">Consists of 550,000 shares issuable under the Infinity Pharmaceuticals, Inc. 2013 Employee Stock Purchase Plan, as amended.</div>
            </td>
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              <div style="font-family: 'Times New Roman';">(3)</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="font-family: 'Times New Roman';">Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act of 1933, as amended, and based upon the average of the high and low
                prices of the Registrant&#8217;s common stock, $0.001 par value per share (&#8220;Common Stock&#8221;) as reported on the Nasdaq Global Market on June 8, 2021.</div>
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    <div style="text-align: center; font-family: 'Times New Roman';"><font style="font-weight: bold;">STATEMENT OF INCORPORATION BY REFERENCE</font></div>
    <div>
      <div style="text-align: center; margin-bottom: 2pt; font-family: 'Times New Roman';"><font style="font-weight: bold;"> <br>
        </font></div>
      <div style="margin-bottom: 2pt; font-family: 'Times New Roman';">This registration statement on Form S-8 is being filed to register an additional 550,000 shares of Common Stock of Infinity Pharmaceuticals, Inc. (the &#8220;Registrant&#8221;) issuable under the
        2013 Employee Stock Purchase Plan, as amended (the &#8220;ESPP&#8221;). Pursuant to General Instruction E to Form S-8, except for Item 5 &#8220;Interests of Named Experts and Counsel&#8221; and Item 8 &#8220;Exhibits,&#8221; this registration statement incorporates by reference (i)
        the contents of the registration statement on Form S-8, File No. 333-189342, filed by the Registrant on June 14, 2013 relating to the ESPP, (ii) the contents of the registration statement on Form S-8, File No. 333-205585, filed by the Registrant on
        July 9, 2015 relating to the ESPP and (iii) the contents of the registration statement on Form S-8, File No. 333-232110, filed by the Registrant on June 14, 2019 relating to the ESPP.</div>
      <div style="margin-bottom: 2pt; font-family: 'Times New Roman';"> <br>
      </div>
      <div style="text-align: center; margin-bottom: 2pt; font-family: 'Times New Roman'; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
      <div style="text-align: center; margin-bottom: 2pt; font-family: 'Times New Roman'; font-weight: bold;"> <br>
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                <div style="margin-bottom: 2pt; font-family: 'Times New Roman'; font-weight: bold;">Interests of Named Experts and Counsel.</div>
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      <div style="margin-bottom: 2pt; font-family: 'Times New Roman'; font-weight: bold;"> <br>
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      <div style="margin-bottom: 2pt; font-family: 'Times New Roman';">Wilmer Cutler Pickering Hale and Dorr LLP has opined as to the legality of the securities being offered by this registration statement.</div>
      <div style="margin-bottom: 2pt; font-family: 'Times New Roman';"> <br>
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                <div style="margin-bottom: 2pt; font-family: 'Times New Roman'; font-weight: bold;">Item 8.</div>
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                <div style="margin-bottom: 2pt; font-family: 'Times New Roman'; font-weight: bold;">&#160;Exhibits.</div>
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      <div style="margin-bottom: 2pt; font-family: 'Times New Roman'; font-weight: bold;"> <br>
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      <div style="margin-bottom: 2pt; font-family: 'Times New Roman';">The Index to Exhibits immediately preceding the exhibits is incorporated herein by reference.<br>
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      <div style="text-align: center;"> <font style="font-weight: bold; font-family: 'Times New Roman';">SIGNATURES</font> </div>
      <div> <font style="font-family: 'Times New Roman';"><br>
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        <div style="margin-bottom: 2pt; font-family: 'Times New Roman';">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
          S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Cambridge, Commonwealth of Massachusetts, on this 11th day of June, 2021.</div>
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          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="vertical-align: top; font-family: 'Times New Roman';" colspan="2">
            <div style="font-weight: bold;">INFINITY PHARMACEUTICALS, INC.</div>
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          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 3%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 47%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
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          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
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            <div>By:</div>
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            <div>/s/ Lawrence E. Bloch</div>
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          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 3%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
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            <div>Lawrence E. Bloch, M.D., J.D.</div>
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          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 3%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
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            <div>President</div>
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  <font style="font-family: 'Times New Roman';">&#160;</font>
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    <div style="text-align: center; font-family: 'Times New Roman';"><!--Anchor--><font style="font-weight: bold;"><!--Anchor--><a name="POWEROFATTORNEYANDSIGNATURES"><!--Anchor--></a>POWER OF ATTORNEY AND SIGNATURES </font></div>
    <div style="margin-top: 12pt; font-family: 'Times New Roman';">We, the undersigned officers and directors of Infinity Pharmaceuticals, Inc., hereby severally constitute and appoint Adelene Q. Perkins, Lawrence E. Bloch, M.D., J.D., and Seth A. Tasker,
      and each of them singly, our true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the registration statement on Form S-8 filed herewith and any and all
      subsequent amendments to said registration statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Infinity Pharmaceuticals, Inc. to comply with the provisions of the
      Securities Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and
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    <div style="margin-top: 12pt; font-family: 'Times New Roman';">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.</div>
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            <div style="text-indent: -9pt; margin-left: 9pt; text-align: center;">Signature</div>
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            <div style="text-align: center;">Date</div>
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          <td rowspan="1" style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td rowspan="1" colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman';" rowspan="1">&#160;</td>
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          <td rowspan="1" style="width: 15%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
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            <div>/s/ Adelene Q. Perkins</div>
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          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman';">
            <div style="text-align: center;">Chief Executive Officer and Chair of the Board of</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';" rowspan="2">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">June 11, 2021</div>
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        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Adelene Q. Perkins</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
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          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
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          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
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          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Lawrence E. Bloch</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman';">
            <div style="text-align: center;">President (Principal Financial Officer and Principal </div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';" rowspan="2">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">June 11, 2021</div>
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          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Lawrence E. Bloch, M.D., J.D.</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">Accounting Officer)</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
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          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
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          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Samuel Agresta</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">June 11, 2021</div>
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        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Samuel Agresta, M.D., M.P.H.</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ David Beier</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">June 11, 2021</div>
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        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">
            <div>David Beier, J.D.</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Anthony B. Evnin</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">June 11, 2021</div>
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          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Anthony B. Evnin, Ph.D.</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
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        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Richard Gaynor</div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">June 11, 2021</div>
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          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Richard Gaynor, M.D.</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
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        <tr>
          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman'; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Norman C. Selby</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; padding-bottom: 2px;">
            <div style="text-align: center;">June 11, 2021</div>
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          <td style="width: 35%; vertical-align: top; font-family: 'Times New Roman';">
            <div>Norman C. Selby</div>
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          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 48%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 1%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 15%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
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    <div><font style="font-family: 'Times New Roman';"><br>
      </font> </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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    <div style="text-align: center; font-family: 'Times New Roman'; font-weight: bold;">INDEX TO EXHIBITS</div>
    <div style="font-family: 'Times New Roman';"><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

        <tr>
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            <div style="text-align: center;">Number</div>
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            <div style="text-align: center;">Description</div>
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            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1113148/000111314820000028/restatedcertificateofi.htm">4.1</a></div>
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            <div>Restated Certificate of Incorporation of the Registrant (previously filed as Exhibit 3.1 to the Registrant&#8217;s Quarterly Report on Form 10-Q for the quarter ended July 30, 2020 (File No. 000-31141) and incorporated herein by reference).</div>
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          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
        </tr>
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          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1113148/000119312509056675/dex31.htm">4.2</a></div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div>Amended and Restated Bylaws of the Registrant. (Previously filed as Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on March 17, 2009 (File No. 000-31141) and incorporated herein by reference).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="nt10025602x1_ex5-1.htm">5.1</a></div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div>Opinion of Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Registrant. Filed herewith.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="nt10025602x1_ex5-1.htm">23.1</a></div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div>Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.1). Filed Herewith.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="nt10025602x1_ex23-2.htm">23.2</a></div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div>Consent of Ernst &amp; Young LLP, independent registered public accounting firm to the Registrant. Filed Herewith.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="#POWEROFATTORNEYANDSIGNATURES">24.1</a></div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div>Power of attorney (included on the signature pages of this registration statement).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1113148/000119312515224821/d943512dex991.htm">99.1</a></div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div>2013 Employee Stock Purchase Plan, as amended by Amendment No. 1 and Amendment&#160; No. 2 thereto. (Previously filed as Exhibit 99.1 to the Registrant&#8217;s Current Report on Form 8-K filed on June 16, 2015 (File No. 000-31141) and incorporated
              herein by reference).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; text-align: center;">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1113148/000119312519115859/d688751ddef14a.htm">99.2</a></div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div>Amendment No. 3 to 2013 Employee Stock Purchase Plan. (Previously filed as Exhibit B to the Registrant&#8217;s Definitive Proxy Statement filed on April 24, 2019 (File No. 000-31141) and incorporated herein by reference).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman';">&#160;</td>
        </tr>
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          <td style="width: 10%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;"><a href="https://www.sec.gov/Archives/edgar/data/1113148/000114036121014200/nc10021449x1_def14a.htm">99.3</a></div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; font-family: 'Times New Roman'; background-color: rgb(204, 238, 255);">
            <div>Amendment No. 4 to 2013 Employee Stock Purchase Plan. (Previously filed as Appendix A to the Registrant&#8217;s Definitive Proxy Statement filed on April 26, 2021 (File No. 000-31141) and incorporated herein by reference).</div>
          </td>
        </tr>

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[{"type": "S-8", "sequence": "1", "filename": "nt10025602x1_s-8.htm", "description": "S-8", "secsgml_size_bytes": 60032}]
{"company-data": {"conformed-name": "INFINITY PHARMACEUTICALS, INC.", "cik": "0001113148", "assigned-sic": "2834", "irs-number": "330655706", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-257029", "film-number": "211011493"}, "business-address": {"street1": "1100 MASSACHUSETTS AVENUE", "street2": "FLOOR 4", "city": "CAMBRIDGE", "state": "MA", "zip": "02138", "phone": "6174531000"}, "mail-address": {"street1": "1100 MASSACHUSETTS AVENUE", "street2": "FLOOR 4", "city": "CAMBRIDGE", "state": "MA", "zip": "02138"}, "former-company": [{"former-conformed-name": "INFINITY PHARMACEUTICALS, INC./NEW/", "date-changed": "20060913"}, {"former-conformed-name": "DISCOVERY PARTNERS INTERNATIONAL INC", "date-changed": "20000428"}]}
As filed with the Securities and Exchange Commission on June 11, 2021
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Infinity Pharmaceuticals, Inc.
(Exact Name of Registrant as Specified in Its Charter)
Delaware
33-0655706
(State or Other Jurisdiction of
Incorporation or Organization)
(I.R.S. Employer
Identification No.)
1100 Massachusetts Avenue, Floor 4
Cambridge, Massachusetts
02138
(Address of Principal Executive Offices)
(Zip Code)
Infinity Pharmaceuticals, Inc. 2013 Employee Stock Purchase Plan, as amended
(Full Title of the Plan)
Seth A. Tasker, Esq.
Senior Vice President, Chief Business Officer
Infinity Pharmaceuticals, Inc.
1100 Massachusetts Avenue, Floor 4
Cambridge, Massachusetts 02138
(Name and Address of Agent For Service)
(617) 453-1000
(Telephone Number, Including Area Code, of Agent For Service)
With copies to:
Cynthia T. Mazareas, Esq.
Wilmer Cutler Pickering Hale and Dorr LLP
60 State Street
Boston, MA 02109
Telephone: (617) 526-6000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of
      "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided
      pursuant to Section 7(a)(2)(B) of the Securities Act.  ☐
CALCULATION OF REGISTRATION FEE
Title of Securities
to be Registered
Amount
to be
Registered(1)
Proposed
Maximum
Offering Price
Per Share
Proposed
Maximum
Aggregate
Offering Price
Amount of
Registration Fee
Common Stock, $0.001 par value per share
550,000 shares(2)
$3.42(3)
$1,881,000(3)
$205.22
(1)
In accordance with Rule 416 under the Securities Act of 1933, as amended, this registration statement shall be deemed to cover any additional securities that may from time to time be offered or
                issued to prevent dilution resulting from stock splits, stock dividends or similar transactions.
(2)
Consists of 550,000 shares issuable under the Infinity Pharmaceuticals, Inc. 2013 Employee Stock Purchase Plan, as amended.
(3)
Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act of 1933, as amended, and based upon the average of the high and low
                prices of the Registrant's common stock, $0.001 par value per share ("Common Stock") as reported on the Nasdaq Global Market on June 8, 2021.
STATEMENT OF INCORPORATION BY REFERENCE
This registration statement on Form S-8 is being filed to register an additional 550,000 shares of Common Stock of Infinity Pharmaceuticals, Inc. (the "Registrant") issuable under the
        2013 Employee Stock Purchase Plan, as amended (the "ESPP"). Pursuant to General Instruction E to Form S-8, except for Item 5 "Interests of Named Experts and Counsel" and Item 8 "Exhibits," this registration statement incorporates by reference (i)
        the contents of the registration statement on Form S-8, File No. 333-189342, filed by the Registrant on June 14, 2013 relating to the ESPP, (ii) the contents of the registration statement on Form S-8, File No. 333-205585, filed by the Registrant on
        July 9, 2015 relating to the ESPP and (iii) the contents of the registration statement on Form S-8, File No. 333-232110, filed by the Registrant on June 14, 2019 relating to the ESPP.
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 5.
Interests of Named Experts and Counsel.
Wilmer Cutler Pickering Hale and Dorr LLP has opined as to the legality of the securities being offered by this registration statement.
Item 8.
Exhibits.
The Index to Exhibits immediately preceding the exhibits is incorporated herein by reference.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
          S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Cambridge, Commonwealth of Massachusetts, on this 11th day of June, 2021.
INFINITY PHARMACEUTICALS, INC.
By:
/s/ Lawrence E. Bloch
Lawrence E. Bloch, M.D., J.D.
President
POWER OF ATTORNEY AND SIGNATURES
We, the undersigned officers and directors of Infinity Pharmaceuticals, Inc., hereby severally constitute and appoint Adelene Q. Perkins, Lawrence E. Bloch, M.D., J.D., and Seth A. Tasker,
      and each of them singly, our true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the registration statement on Form S-8 filed herewith and any and all
      subsequent amendments to said registration statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Infinity Pharmaceuticals, Inc. to comply with the provisions of the
      Securities Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and
      all amendments thereto.
Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Adelene Q. Perkins
Chief Executive Officer and Chair of the Board of
June 11, 2021
Adelene Q. Perkins
Directors (Principal Executive Officer)
/s/ Lawrence E. Bloch
President (Principal Financial Officer and Principal
June 11, 2021
Lawrence E. Bloch, M.D., J.D.
Accounting Officer)
/s/ Samuel Agresta
Director
June 11, 2021
Samuel Agresta, M.D., M.P.H.
/s/ David Beier
Director
June 11, 2021
David Beier, J.D.
/s/ Anthony B. Evnin
Director
June 11, 2021
Anthony B. Evnin, Ph.D.
/s/ Richard Gaynor
Director
June 11, 2021
Richard Gaynor, M.D.
/s/ Norman C. Selby
Director
June 11, 2021
Norman C. Selby
INDEX TO EXHIBITS
Number
Description
4.1
Restated Certificate of Incorporation of the Registrant (previously filed as Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q for the quarter ended July 30, 2020 (File No. 000-31141) and incorporated herein by reference).
4.2
Amended and Restated Bylaws of the Registrant. (Previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on March 17, 2009 (File No. 000-31141) and incorporated herein by reference).
5.1
Opinion of Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Registrant. Filed herewith.
23.1
Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.1). Filed Herewith.
23.2
Consent of Ernst & Young LLP, independent registered public accounting firm to the Registrant. Filed Herewith.
24.1
Power of attorney (included on the signature pages of this registration statement).
99.1
2013 Employee Stock Purchase Plan, as amended by Amendment No. 1 and Amendment  No. 2 thereto. (Previously filed as Exhibit 99.1 to the Registrant's Current Report on Form 8-K filed on June 16, 2015 (File No. 000-31141) and incorporated
              herein by reference).
99.2
Amendment No. 3 to 2013 Employee Stock Purchase Plan. (Previously filed as Exhibit B to the Registrant's Definitive Proxy Statement filed on April 24, 2019 (File No. 000-31141) and incorporated herein by reference).
99.3
Amendment No. 4 to 2013 Employee Stock Purchase Plan. (Previously filed as Appendix A to the Registrant's Definitive Proxy Statement filed on April 26, 2021 (File No. 000-31141) and incorporated herein by reference).