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<B><FONT SIZE=2><P ALIGN="RIGHT">As filed with the Securities and Exchange Commission on August 4, 2010 &nbsp;&nbsp;&nbsp;&nbsp;<BR>

                  Registration No. __________</B></FONT></TD>
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<FONT SIZE=1>
</FONT><B><FONT SIZE=4><P ALIGN="CENTER">UNITED STATES<BR>
                  SECURITIES AND EXCHANGE COMMISSION<BR>
</FONT><FONT SIZE=3>                  WASHINGTON, D.C. 20549</B></FONT></TD>
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<H3 ALIGN="CENTER"></H3>
<FONT SIZE=5><H3 ALIGN="CENTER">FORM S-8</H3>
</FONT><H3 ALIGN="CENTER"></H3>
<B><P ALIGN="CENTER">REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</P>
</B><FONT SIZE=1><P ALIGN="CENTER"></FONT></TD>
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<B><FONT SIZE=6><P ALIGN="CENTER">NPS PHARMACEUTICALS, INC.</B></FONT><BR>
<FONT SIZE=1>(Exact name of Registrant as specified in its charter)</FONT></TD>
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<B><FONT SIZE=2><P ALIGN="CENTER">Delaware</B></FONT></TD>
<TD WIDTH="47%" VALIGN="MIDDLE">
<B><FONT SIZE=2><P ALIGN="CENTER">87-0439579</B></FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">(State or other jurisdiction of<BR>
incorporation or organization)</FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">(I.R.S. Employer <BR>
Identification No.)</FONT></TD>
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<B><FONT SIZE=2>
<P ALIGN="CENTER">550 Hills Drive, 3<SUP>rd</SUP> Fl. <BR>
Bedminster, New Jersey  07921<BR>
</B></FONT><FONT SIZE=1>                  (Address of Principal Executive Offices)<BR>&nbsp; </FONT></TD>
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<B><FONT SIZE=2>
<P ALIGN="CENTER">NPS Pharmaceuticals, Inc.<BR>
                  2010 Employee Stock Purchase Plan<BR>
</B></FONT><FONT SIZE=1>                  (Full title of the plan)<BR>&nbsp; </FONT></TD>
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<B><FONT SIZE=2>
<P ALIGN="CENTER">Edward Stratemeier, Senior Vice President, Legal Affairs and General Counsel<BR>
                  NPS Pharmaceuticals, Inc.<BR>
                  550 Hills Drive, 3<SUP>rd</SUP> Fl. <BR>
Bedminster, New Jersey  07921<BR>
                  Telephone: (908) 450-5300<BR>
</B></FONT>                   <FONT SIZE=1>(Name, address, including zip code, and telephone number, including
area code, of agent for service)</P>
</FONT><FONT SIZE=2><P ALIGN="CENTER"></FONT></TD>
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<I><FONT SIZE=2><P ALIGN="CENTER">With a copy to:</I><BR>&nbsp; </FONT></TD>
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<B><FONT SIZE=2>
<P ALIGN="CENTER">Lawrence Goodman, Esq.<BR>
                  Curtis, Mallet-Prevost, Colt &amp; Mosle LLP<BR>
                  101 Park Avenue<BR>
                  New York, New York 10178<BR>
                  (212) 696-6000<BR>
</B>                  (Counsel to the Registrant)</P>
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<P>
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller
reporting company.  See the definitions of &quot;large accelerated filer,&quot; &quot;accelerated filer,&quot; and &quot;smaller reporting company&quot; in Rule 12b-2 of the Exchange Act. (Check one):

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<FONT SIZE=1><P>Large accelerated filer&#12288;<FONT FACE="Wingdings">&#111;</FONT>
</FONT></TD>
<TD WIDTH="22%" VALIGN="TOP">
<FONT SIZE=1><P ALIGN="CENTER">Accelerated filer&#12288;<FONT FACE="Wingdings">&#254;</FONT>
</FONT></TD>
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<FONT SIZE=1><P ALIGN="CENTER">Non-accelerated filer&#12288;<FONT FACE="Wingdings">&#111;</FONT><BR>
(Do not check if a smaller <BR>
reporting company)</FONT></TD>
<TD WIDTH="28%" VALIGN="TOP">
<FONT SIZE=1><P ALIGN="CENTER">Smaller reporting company&#12288;<FONT FACE="Wingdings">&#111;</FONT>
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<B><P ALIGN="CENTER">CALCULATION OF REGISTRATION FEE </P></B>

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<FONT SIZE=1><P ALIGN="CENTER">Title of securities to be<BR>
registered</FONT></TD>
<TD WIDTH="19%" VALIGN="BOTTOM">
<FONT SIZE=1><P ALIGN="CENTER">Amount to be<BR>
registered (1)</FONT></TD>
<TD WIDTH="19%" VALIGN="BOTTOM">
<FONT SIZE=1><P ALIGN="CENTER">Proposed<BR>
maximum<BR>
offering price<BR>
per share (2)</FONT></TD>
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<FONT SIZE=1><P ALIGN="CENTER">Proposed<BR>
maximum<BR>
aggregate<BR>
offering price (2)</FONT></TD>
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<FONT SIZE=1><P ALIGN="CENTER">Amount of<BR>
registration fee (2)</FONT></TD>
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<FONT SIZE=1><P>Common Stock, $0.001 par value per share</FONT></TD>
<TD WIDTH="19%" VALIGN="BOTTOM">
<FONT SIZE=1><P ALIGN="CENTER">500,000</FONT></TD>
<TD WIDTH="19%" VALIGN="BOTTOM">
<FONT SIZE=1><P ALIGN="CENTER">$ 6.67</FONT></TD>
<TD WIDTH="19%" VALIGN="BOTTOM">
<FONT SIZE=1><P ALIGN="CENTER">$ 3,335,000</FONT></TD>
<TD WIDTH="19%" VALIGN="BOTTOM">
<FONT SIZE=1><P ALIGN="CENTER">$ 237.79</FONT></TD>
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<FONT SIZE=1><P>(1)
</FONT></TD>
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<FONT SIZE=1><P>
Pursuant to Rule 416 of the Securities Act of 1933, as amended (the &quot;Securities Act&quot;), this Registration Statement also includes additional securities
that may be offered or issued as part of any stock split, stock dividend or similar transaction.
</FONT></TD>
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<FONT SIZE=1><P>(2)
</FONT></TD>
<TD WIDTH="96%" VALIGN="TOP">
<FONT SIZE=1><P>
Calculated using the average of the high and low sales price of the Registrant's Common Stock on the NASDAQ Global Market on July 28, 2010
pursuant to paragraph (c) and (h) of Rule 457 under the Securities Act.
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<B><U><FONT SIZE=3><P ALIGN="CENTER">TABLE OF CONTENTS</B></U></FONT></TD>
</TR>
<TR><TD WIDTH="95%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="5%" VALIGN="TOP">&#12288;</TD>
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<U><FONT SIZE=2><P>INTRODUCTORY STATEMENT</U></FONT></TD>
<TD WIDTH="5%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">3</FONT></TD>
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<U><FONT SIZE=2><P>PART II</U></FONT></TD>
<TD WIDTH="5%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">3</FONT></TD>
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<U><FONT SIZE=2><P>ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE </U></FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">3</FONT></TD>
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<U><FONT SIZE=2><P>ITEM 4.  DESCRIPTION OF SECURITIES</U></FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">3</FONT></TD>
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<U><FONT SIZE=2><P>ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL</U></FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">3</FONT></TD>
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<U><FONT SIZE=2><P>ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS</U></FONT></TD>
<TD WIDTH="5%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">3</FONT></TD>
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<U><FONT SIZE=2><P>ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED</U></FONT></TD>
<TD WIDTH="5%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">4</FONT></TD>
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<U><FONT SIZE=2><P>ITEM 8.  EXHIBITS</U></FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">4</FONT></TD>
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<U><FONT SIZE=2><P>ITEM 9.  UNDERTAKINGS</U></FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">5</FONT></TD>
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<U><FONT SIZE=2><P>SIGNATURES</U></FONT></TD>
<TD WIDTH="5%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">6</FONT></TD>
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<U><FONT SIZE=2><P>POWER OF ATTORNEY</U></FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">6</FONT></TD>
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<U><FONT SIZE=2><P>EXHIBIT INDEX</U></FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">8</FONT></TD>
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<U><FONT SIZE=2><P>EXHIBIT 5.1</U></FONT></TD>
<TD WIDTH="5%" VALIGN="TOP">&#12288;</TD>
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<U><FONT SIZE=2><P>EXHIBIT 23.1</U></FONT></TD>
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<U><FONT SIZE=2><P>EXHIBIT 23.2</U></FONT></TD>
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<U><FONT SIZE=2><P>EXHIBIT 24.1</U></FONT></TD>
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<P ALIGN="CENTER">                            -2- </P>
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<P style="PAGE-BREAK-BEFORE: always" align=left>

<B><U><FONT FACE="Times New Roman Bold,Times New Roman" SIZE=2><FONT FACE="Times New Roman
Bold,Times New Roman" SIZE=2>
</B></U></FONT></FONT><FONT SIZE=1>
</FONT><B><FONT COLOR="#ff0000">
</FONT><U><FONT FACE="Times New Roman Bold,Times New Roman" SIZE=2 COLOR="#ff0000"><FONT
FACE="Times New Roman Bold,Times New Roman" SIZE=2 COLOR="#ff0000"><FONT FACE="Times New Roman
Bold,Times New Roman" SIZE=2 COLOR="#ff0000">
</FONT></FONT></FONT><FONT FACE="Times New Roman Bold,Times New Roman" SIZE=2><FONT FACE="Times
New Roman Bold,Times New Roman" SIZE=2><P ALIGN="CENTER">INTRODUCTORY STATEMENT</P>
</B></U></FONT></FONT><FONT SIZE=2><P>&#9;This Registration Statement on Form S-8 is being filed by NPS
Pharmaceuticals, Inc. (the &quot;<U>Company</U>&quot;) to register 500,000 shares of the Company's Common Stock to
be issued pursuant to the NPS Pharmaceuticals, Inc. 2010 Employee Stock Purchase Plan. </P>
</FONT><B><FONT FACE="Times New Roman Bold,Times New Roman" SIZE=2><FONT FACE="Times New Roman
Bold,Times New Roman" SIZE=2><P ALIGN="CENTER">PART II.</P>
<P ALIGN="CENTER">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</P>
</FONT></FONT><FONT SIZE=2><P>Item 3.&#9;&#9;Incorporation of Documents by Reference.</P>
</B><P>&#9;The Company hereby incorporates by reference the following documents filed with the Commission:</P>
<P>&#9;(a)  The Company's Annual Report on Form 10-K filed for the fiscal year ended December 31, 2009, filed on March
11, 2010; </P>
<P>&#9;(b)  The Company's Quarterly Reports on Form 10-Q filed on May 5, 2010 and August 4, 2010;</P>
<P>&#9;(c)  The Company's Current Reports on Form 8-K filed on January 22, 2010, March 2, 2010, April 16, 2010 (other
than portions of such document deemed not to be filed), April 21, 2010, May 24, 2010 and July 22, 2010; </P>
<P>(d)  The description of the Company's Common Stock contained in the Company's Registration Statement on
Form&#12288;8-A filed with the Commission on May 23, 1994, including any amendment or report filed with the Commission
for the purpose of updating such description.</P>
<P>&#9;In addition, all documents filed by the Company with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d)
of the Securities Exchange Act of 1934, as amended (the &quot;<U>Exchange Act</U>&quot;) (other than portions of such
documents deemed not to be filed) after the date of this Registration Statement and prior to the filing of a post-effective
amendment which indicates that all securities registered hereby have been sold or which deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof
from the date of the filing of such documents.  </P>
<B><P>Item 4.&#9;&#9;Description of Securities.</P>

<P>&#9;</B>Not applicable.</P>
</FONT><FONT SIZE=2 COLOR="#ff0000"><FONT SIZE=2 COLOR="#ff0000">
</FONT></FONT><B><FONT SIZE=2><P>Item 5.&#9;&#9;Interests of Named Experts and Counsel.</P>

</B><P>&#9;Not applicable.</P>
</FONT><B><FONT SIZE=2 COLOR="#ff0000"><FONT SIZE=2 COLOR="#ff0000">
</FONT></FONT><FONT SIZE=2><P>Item 6. &#9;&#9;Indemnification of Directors and Officers.</P>
</B></FONT><P>&#12288;<FONT SIZE=2>Under Section 145 of the Delaware General Corporation Law, the Company has
broad powers to indemnify its directors and officers against liabilities they may incur in such capacities, including liabilities
under the Securities Act of 1933, as amended (the &quot;<U>Securities Act</U>&quot;).  The Company's Bylaws also
provide that it will indemnify its directors and executive officers and may indemnify its other officers, employees and other
agents to the fullest extent not prohibited by Delaware law. </P>
<P>The Company's Amended Certificate of Incorporation provides for the elimination of liability for monetary damages for
breach of the directors' fiduciary duty of care to the Company and its stockholders.  These provisions do not eliminate the
directors' duty of care and, in appropriate circumstances, equitable remedies such as injunctive or other forms of non-
monetary relief will remain available under Delaware law.  In addition, each director will continue to be subject to liability for
breach of the director's duty of loyalty to the Company, for acts or omissions not in good faith or involving intentional
misconduct, for knowing violations of law, for any transaction from which the director derived an improper personal benefit
and for payment of dividends or approval of stock repurchases or redemptions that are unlawful under Delaware law.  The
provision does not affect a director's responsibilities under any other laws, such as the federal securities laws or state or
federal environmental laws. </P>

<P ALIGN="CENTER">                            -3- </P>
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<P>The Company entered into agreements with its directors and executive officers that require it to indemnify such persons
against expenses, judgments, fines, settlements and other amounts actually and reasonably incurred, including expenses of a
derivative action in connection with any proceeding, whether actual or threatened, to which any such person may be made a
party by reason of the fact that such person is or was a director or officer of the Company or a director or officer of one of its
affiliated enterprises, provided such person acted in good faith and in a manner such person reasonably believed to be in or
not opposed to the Company's best interests and, with respect to any criminal proceeding, had no reasonable cause to
believe his or her conduct was unlawful.  The indemnification agreements also set forth certain procedures that will apply in
the event of a claim for indemnification thereunder.</P>
</FONT><FONT SIZE=2 COLOR="#ff0000"><FONT SIZE=2 COLOR="#ff0000">
</FONT></FONT><B><FONT SIZE=2><P>Item 7.&#9;&#9;Exemption from Registration Claimed.</P>
</B>
<P>&#9;Not applicable.</P>
</FONT><B><FONT SIZE=2 COLOR="#ff0000"><FONT SIZE=2 COLOR="#ff0000">
</FONT></FONT><FONT SIZE=2><P>Item 8.&#9;&#9;Exhibits.</P></B>

<P ALIGN="CENTER"><CENTER><TABLE BORDER=0 CELLSPACING=1 CELLPADDING=2 WIDTH=98%>
<TR><TD WIDTH="10%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="39%" VALIGN="BOTTOM">&#12288;</TD>
<TD WIDTH="39%" VALIGN="BOTTOM" COLSPAN=4>
<B><FONT SIZE=2><P ALIGN="CENTER">Incorporated by Reference</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="11%" VALIGN="BOTTOM">&#12288;</TD>
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<B><FONT SIZE=2><P>Exhibit<BR>
   No.</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
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<B><FONT SIZE=2><P ALIGN="CENTER">Exhibit</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="7%" VALIGN="BOTTOM">
<B><FONT SIZE=2><P ALIGN="CENTER">Form</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
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<B><FONT SIZE=2><P ALIGN="CENTER">File No.</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="11%" VALIGN="BOTTOM">
<B><FONT SIZE=2><P ALIGN="CENTER">Filing Date</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="10%" VALIGN="BOTTOM">
<B><FONT SIZE=2><P ALIGN="CENTER">Exhibit<BR>No.</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="11%" VALIGN="BOTTOM">
<B><FONT SIZE=2><P ALIGN="CENTER">Filed<BR>
                  Herewith</B>
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<FONT SIZE=2><P>  4.1A</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP">
<FONT SIZE=2><P>Amended and Restated Certificate of Incorporation of the Registrant.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">10-K</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">000-23272</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">03/08/2005</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">3.1A</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P>  4.1B</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP">
<FONT SIZE=2><P>Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Registrant,
dated December 16, 1999. </FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">S-3</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">333-45274</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">09/06/2000</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">3.3</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
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<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>  4.1C</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Registrant,
dated September 30, 2003.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">10-K</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">000-23272</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">02/10/2004</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">3.1E</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10><P></P></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>  4.2A</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>Amended and Restated Bylaws of the Registrant.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">10-K</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">000-23272</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">03/08/2005</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">3.1A</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10><P></P></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>  4.2B</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>Certificate of Adoption of Amendments to the Amended and Restated Bylaws of the Registrant, dated
February 19, 2003.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">10-K</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">000-23272</P>
<P ALIGN="CENTER"></FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">03/21/2003</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">3.2B</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10><P></P></TD>
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<FONT SIZE=2><P>  4.3</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>Specimen Common Stock Certificate.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">S-1</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">333-74318</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">01/21/1994</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">4.1</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10><P></P></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>  5.1</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>Opinion of Curtis, Mallet-Prevost, Colt &amp; Mosle LLP as to the legality of the shares being registered.
</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">X</FONT></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P>  23.1</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP">
<FONT SIZE=2><P>Consent of Curtis, Mallet-Prevost, Colt &amp; Mosle LLP (included in Exhibit 5.1).</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="10%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">X</FONT></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P>  23.2</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP">
<FONT SIZE=2><P>Consent of KPMG LLP, Independent Registered Public Accounting Firm.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="10%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">X</FONT></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>  24.1</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>Power of Attorney (included on the signature page to this Registration Statement on Form S-
8).</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">X</FONT></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>99.1</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>NPS Pharmaceuticals, Inc. 2010 Employee Stock Purchase Plan </FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">8-K</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">000-23272</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">05/24/2010</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">10.1</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25><P></P></TD>
</TR>
</TABLE>
</CENTER></P>

<P ALIGN="CENTER">                            -4- </P>
<HR WIDTH="100%">
<P style="PAGE-BREAK-BEFORE: always" align=left>

<B><U><FONT SIZE=2 COLOR="#ff0000"><FONT SIZE=2 COLOR="#ff0000">
</U></FONT></FONT><FONT SIZE=2>
<P>Item 9.&#9;&#9;Undertakings.</P></B>

<P>The undersigned Company hereby undertakes:</P>

<OL TYPE="a">
<LI>
<OL>

<LI>To file, during any period in which offers or sales of the securities registered hereby are being made, a post-effective
amendment to this Registration Statement: </LI>


<DIR>

<P>(i) to include any prospectus required by Section 10(a)(3) of the Securities Act; </P>

<P>(ii) to reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the
most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the
information set forth in this Registration Statement.  Notwithstanding the foregoing, any increase or decrease in volume of
securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation
from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the
Commission pursuant to Rule 424(b), if, in the aggregate, the changes in volume and price represent no more than a 20
percent change in the maximum aggregate offering price set forth in the &quot;Calculation of Registration Fee&quot; table in
the effective Registration Statement; and </P>

<P>(iii) to include any material information with respect to the plan of distribution not previously disclosed in this Registration
Statement or any material change to such information in this Registration Statement; p<I>rovided</I>, <I>however</I>, that
paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by
those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Company pursuant to
Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.</P>

</DIR>


<P><LI>That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be
deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that
time shall be deemed to be the initial <I>bona fide</I> offering thereof.</LI>

<P><LI>To remove from registration by means of a post-effective amendment any of the securities being registered which remain
unsold at the termination of the offering.</LI>
</OL>


<P><LI>The undersigned Company hereby undertakes that, for purposes of determining any liability under the Securities Act,
each filing of the Company's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated
by reference in this Registration Statement shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be deemed to be the initial <I>bona fide</I> offering
thereof.</LI>

<P><LI>Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and
controlling persons of the Company pursuant to the foregoing provisions, or otherwise, the Company has been advised that in
the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is,
therefore unenforceable.  In the event that a claim for indemnification against such liabilities (other than the payment by the
Company of expenses incurred or paid by a director, officer or controlling person of the Company in the successful defense of
any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being
registered, the Company will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit
to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in
the Securities Act and will be governed by the final adjudication of such issue.</LI></OL>


<P ALIGN="CENTER">                            -5- </P>
<HR WIDTH="100%">
<P style="PAGE-BREAK-BEFORE: always" align=left>


<B><U>
<P ALIGN="CENTER">SIGNATURES</P>

</B></U><P>&#9;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable
grounds to believe that it meets all of the requirements for filing on Form&#12288;S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Bedminster, New Jersey, on this 4th
day of August, 2010.</P><DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>
<DIR>

<B><P>&#9;NPS Pharmaceuticals, Inc.</P>


</B><P>By:  <U>/s/ Francois Nader&#9;&#9;&#9;</U><BR>
Name:  Francois Nader<BR>
Title:  President and Chief Executive Officer</P>


</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>
</DIR>

</FONT></FONT><B><U><FONT SIZE=2><P ALIGN="CENTER">POWER OF ATTORNEY</P>
</U>
</B><P>&#9;KNOW BY ALL THESE PRESENTS, that&#12288;each person whose signature appears below constitutes and
appoints Edward Stratemeier and  Luke M. Beshar, and each of them acting individually, as his or her true and lawful
attorney-in-fact, with full power of substitution and resubstitution, for him or her and in his or her name, place, and stead, in
any and all capacities, to sign any or all amendments (including post-effective amendments) to this Registration Statement,
and to file the same, with all the exhibits thereto, and other documents in connection therewith, with the Commission, granting
unto said attorneys-in-fact, each acting alone, full power and authority to do and perform each and every act and thing
requisite or necessary to be done in and about the premises as fully, to all intents and purposes, as he or she might or could
do in person, hereby ratifying and confirming all that said attorneys-in-fact, each acting alone, or his substitute or substitutes,
may lawfully do or cause to be done by virtue hereof.  This Power of Attorney may be executed in any number of
counterparts, each of which when so executed and delivered shall be deemed an original and such counterparts shall
together constitute one and the same instrument.  Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the capacities and on the dates indicated.  </P>

<P ALIGN="CENTER"><CENTER><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=2 WIDTH=99%>
<TR><TD WIDTH="31%" VALIGN="TOP">
<B><U><FONT SIZE=2><P ALIGN="CENTER">Signature</B></U></FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">
<B><U><FONT SIZE=2><P ALIGN="CENTER">Title</P>
</B></U></FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">
<B><U><FONT SIZE=2><P ALIGN="CENTER">Date</B></U></FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<U><FONT SIZE=2><P>/s/ Francois Nader&#9;</U></FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Francois Nader</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">
<FONT SIZE=2><P>Director, President and Chief Executive Officer (principal executive officer)</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">August 4, 2010</FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<U><FONT SIZE=2><P>/s/ Luke M. Beshar&#9;</U></FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Luke M. Beshar</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">
<FONT SIZE=2><P>Senior Vice President and Chief Financial Officer (principal financial and accounting
officer)</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">August 4, 2010</FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<U><FONT SIZE=2><P>/s/ Michael W. Bonney&#9;</U></FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">Michael W. Bonney</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="43%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>Director </FONT></TD>
<TD WIDTH="2%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="21%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">August 4, 2010</FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<U><FONT SIZE=2><P>/s/ Colin Broom&#9;&#9;</U></FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Colin Broom</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">
<FONT SIZE=2><P>Director</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">August 4, 2010</FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP" HEIGHT=22><P></P></TD>
<TD WIDTH="2%" VALIGN="TOP" HEIGHT=22><P></P></TD>
<TD WIDTH="43%" VALIGN="TOP" HEIGHT=22><P></P></TD>
<TD WIDTH="2%" VALIGN="TOP" HEIGHT=22><P></P></TD>
<TD WIDTH="21%" VALIGN="TOP" HEIGHT=22><P></P></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP" HEIGHT=10>
<U><FONT SIZE=2><P>/s/ James G. Groninger    &#9;</U></FONT></TD>
<TD WIDTH="2%" VALIGN="TOP" HEIGHT=10><P></P></TD>
<TD WIDTH="43%" VALIGN="TOP" HEIGHT=10><P></P></TD>
<TD WIDTH="2%" VALIGN="TOP" HEIGHT=10><P></P></TD>
<TD WIDTH="21%" VALIGN="TOP" HEIGHT=10><P></P></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP" HEIGHT=18>
<FONT SIZE=2><P ALIGN="CENTER">James G. Groninger</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP" HEIGHT=18><P></P></TD>
<TD WIDTH="43%" VALIGN="TOP" HEIGHT=18>
<FONT SIZE=2><P>Director </FONT></TD>
<TD WIDTH="2%" VALIGN="TOP" HEIGHT=18><P></P></TD>
<TD WIDTH="21%" VALIGN="TOP" HEIGHT=18>
<FONT SIZE=2><P ALIGN="CENTER">August 4, 2010</FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP" HEIGHT=5><P></P></TD>
<TD WIDTH="2%" VALIGN="TOP" HEIGHT=5><P></P></TD>
<TD WIDTH="43%" VALIGN="TOP" HEIGHT=5><P></P></TD>
<TD WIDTH="2%" VALIGN="TOP" HEIGHT=5><P></P></TD>
<TD WIDTH="21%" VALIGN="TOP" HEIGHT=5><P></P></TD>
</TR>
</TABLE>
</CENTER></P>

<P ALIGN="CENTER">                            -6- </P>
<HR WIDTH="100%">
<P style="PAGE-BREAK-BEFORE: always" align=left>

<P ALIGN="CENTER"><CENTER><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=2 WIDTH=99%>
<TR><TD WIDTH="31%" VALIGN="TOP">
<U><FONT SIZE=2><P>/s/ Donald E. Kuhla&#9;</U></FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Donald E. Kuhla</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">
<FONT SIZE=2><P>Director </FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">August 4, 2010</FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<U><FONT SIZE=2><P>/s/ Rachel R. Selisker    &#9;</U></FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Rachel R. Selisker</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">
<FONT SIZE=2><P>Director </FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">August 4, 2010</FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<U><FONT SIZE=2><P>/s/ Peter G. Tombros&#9;</U></FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">Peter G. Tombros</FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">
<FONT SIZE=2><P>Chairman of the Board of Directors </FONT></TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">August 4, 2010</FONT></TD>
</TR>
<TR><TD WIDTH="31%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="43%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="2%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="21%" VALIGN="TOP">&#12288;</TD>
</TR>
</TABLE>
</CENTER></P>

<P ALIGN="CENTER">                            -7- </P>
<HR WIDTH="100%">
<P style="PAGE-BREAK-BEFORE: always" align=left>


<B><U><FONT SIZE=2><P ALIGN="CENTER">EXHIBIT INDEX</P>
</U></B>

<P ALIGN="CENTER"><CENTER><TABLE BORDER=0 CELLSPACING=1 CELLPADDING=2 WIDTH=98%>
<TR><TD WIDTH="10%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="39%" VALIGN="BOTTOM">&#12288;</TD>
<TD WIDTH="39%" VALIGN="BOTTOM" COLSPAN=4>
<B><FONT SIZE=2><P ALIGN="CENTER">Incorporated by Reference</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="11%" VALIGN="BOTTOM">&#12288;</TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP">
<B><FONT SIZE=2><P>Exhibit<BR>
   No.</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="39%" VALIGN="BOTTOM">
<B><FONT SIZE=2><P ALIGN="CENTER">Exhibit</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="7%" VALIGN="BOTTOM">
<B><FONT SIZE=2><P ALIGN="CENTER">Form</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="11%" VALIGN="BOTTOM">
<B><FONT SIZE=2><P ALIGN="CENTER">File No.</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="11%" VALIGN="BOTTOM">
<B><FONT SIZE=2><P ALIGN="CENTER">Filing Date</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="10%" VALIGN="BOTTOM">
<B><FONT SIZE=2><P ALIGN="CENTER">Exhibit<BR>No.</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
<TD WIDTH="11%" VALIGN="BOTTOM">
<B><FONT SIZE=2><P ALIGN="CENTER">Filed<BR>
                  Herewith</B>
<HR NOSHADE SIZE=2>
</FONT></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P>  4.1A</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP">
<FONT SIZE=2><P>Amended and Restated Certificate of Incorporation of the Registrant.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">10-K</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">000-23272</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">03/08/2005</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">3.1A</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P>  4.1B</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP">
<FONT SIZE=2><P>Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Registrant,
dated December 16, 1999. </FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">S-3</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">333-45274</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">09/06/2000</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">3.3</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>  4.1C</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Registrant,
dated September 30, 2003.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">10-K</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">000-23272</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">02/10/2004</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">3.1E</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10><P></P></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>  4.2A</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>Amended and Restated Bylaws of the Registrant.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">10-K</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">000-23272</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">03/08/2005</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">3.1A</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10><P></P></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>  4.2B</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>Certificate of Adoption of Amendments to the Amended and Restated Bylaws of the Registrant, dated
February 19, 2003.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">10-K</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">000-23272</P>
<P ALIGN="CENTER"></FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">03/21/2003</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">3.2B</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10><P></P></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>  4.3</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P>Specimen Common Stock Certificate.</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">S-1</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">333-74318</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">01/21/1994</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=10>
<FONT SIZE=2><P ALIGN="CENTER">4.1</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=10><P></P></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>  5.1</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>Opinion of Curtis, Mallet-Prevost, Colt &amp; Mosle LLP as to the legality of the shares being registered.
&nbsp;&nbsp;&nbsp;&nbsp; <A HREF="exhibit5-1.pdf"><SUP>PDF</SUP></A> </FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER"><A HREF="exh5-1.htm">X</A></FONT></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P>  23.1</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP">
<FONT SIZE=2><P>Consent of Curtis, Mallet-Prevost, Colt &amp; Mosle LLP (included in Exhibit 5.1).</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="10%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER">X</FONT></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP">
<FONT SIZE=2><P>  23.2</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP">
<FONT SIZE=2><P>Consent of KPMG LLP, Independent Registered Public Accounting Firm.
&nbsp;&nbsp;&nbsp;&nbsp; <A HREF="exhibit23-2.pdf"><SUP>PDF</SUP></A> </FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="10%" VALIGN="TOP">&#12288;</TD>
<TD WIDTH="11%" VALIGN="TOP">
<FONT SIZE=2><P ALIGN="CENTER"><A HREF="exh23-2.htm">X</A></FONT></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>  24.1</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>Power of Attorney (included on the signature page to this Registration Statement on Form S-
8).</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=25><P></P></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">X</FONT></TD>
</TR>
<TR><TD WIDTH="10%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>99.1</FONT></TD>
<TD WIDTH="39%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P>NPS Pharmaceuticals, Inc. 2010 Employee Stock Purchase Plan </FONT></TD>
<TD WIDTH="7%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">8-K</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">000-23272</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">05/24/2010</FONT></TD>
<TD WIDTH="10%" VALIGN="TOP" HEIGHT=25>
<FONT SIZE=2><P ALIGN="CENTER">10.1</FONT></TD>
<TD WIDTH="11%" VALIGN="TOP" HEIGHT=25><P></P></TD>
</TR>
</TABLE>
</CENTER></P>


<P ALIGN="CENTER">                            -8- </P>
<HR WIDTH="100%">
<P style="PAGE-BREAK-BEFORE: always" align=left>


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{"company-data": {"conformed-name": "NPS PHARMACEUTICALS INC", "cik": "0000890465", "assigned-sic": "2836", "irs-number": "870439579", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-168533", "film-number": "10991732"}, "business-address": {"street1": "550 HILLS DRIVE", "city": "BEDMINSTER", "state": "NJ", "zip": "07921", "phone": "(908) 450-5300"}, "mail-address": {"street1": "550 HILLS DRIVE", "city": "BEDMINSTER", "state": "NJ", "zip": "07921"}}
August 4, 2010 S-8 DOC
PDF
provided as courtesy
As filed with the Securities and Exchange Commission on August 4, 2010
Registration No. __________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
NPS PHARMACEUTICALS, INC.
(Exact name of Registrant as specified in its charter)
Delaware
87-0439579
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
550 Hills Drive, 3
rd
Fl.
Bedminster, New Jersey  07921
(Address of Principal Executive Offices)
NPS Pharmaceuticals, Inc.
2010 Employee Stock Purchase Plan
(Full title of the plan)
Edward Stratemeier, Senior Vice President, Legal Affairs and General Counsel
NPS Pharmaceuticals, Inc.
550 Hills Drive, 3
rd
Fl.
Bedminster, New Jersey  07921
Telephone: (908) 450-5300
(Name, address, including zip code, and telephone number, including
area code, of agent for service)
With a copy to:
Lawrence Goodman, Esq.
Curtis, Mallet-Prevost, Colt & Mosle LLP
101 Park Avenue
New York, New York 10178
(212) 696-6000
(Counsel to the Registrant)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller
reporting company.  See the definitions of "large accelerated filer," "accelerated filer," and "smaller reporting company" in Rule 12b-2 of the Exchange Act. (Check one):
Large accelerated filer
o
Accelerated filer
þ
Non-accelerated filer
o
(Do not check if a smaller
reporting company)
Smaller reporting company
o
CALCULATION OF REGISTRATION FEE
Title of securities to be
registered
Amount to be
registered (1)
Proposed
maximum
offering price
per share (2)
Proposed
maximum
aggregate
offering price (2)
Amount of
registration fee (2)
Common Stock, $0.001 par value per share
500,000
$ 6.67
$ 3,335,000
$ 237.79
(1)
Pursuant to Rule 416 of the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement also includes additional securities
that may be offered or issued as part of any stock split, stock dividend or similar transaction.
(2)
Calculated using the average of the high and low sales price of the Registrant's Common Stock on the NASDAQ Global Market on July 28, 2010
pursuant to paragraph (c) and (h) of Rule 457 under the Securities Act.
TABLE OF CONTENTS
INTRODUCTORY STATEMENT
3
PART II
3
ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE
3
ITEM 4.  DESCRIPTION OF SECURITIES
3
ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL
3
ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS
3
ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED
4
ITEM 8.  EXHIBITS
4
ITEM 9.  UNDERTAKINGS
5
SIGNATURES
6
POWER OF ATTORNEY
6
EXHIBIT INDEX
8
EXHIBIT 5.1
EXHIBIT 23.1
EXHIBIT 23.2
EXHIBIT 24.1
-2-
INTRODUCTORY STATEMENT
This Registration Statement on Form S-8 is being filed by NPS
Pharmaceuticals, Inc. (the "
Company
") to register 500,000 shares of the Company's Common Stock to
be issued pursuant to the NPS Pharmaceuticals, Inc. 2010 Employee Stock Purchase Plan.
PART II.
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.		Incorporation of Documents by Reference.
The Company hereby incorporates by reference the following documents filed with the Commission:
(a)  The Company's Annual Report on Form 10-K filed for the fiscal year ended December 31, 2009, filed on March
11, 2010;
(b)  The Company's Quarterly Reports on Form 10-Q filed on May 5, 2010 and August 4, 2010;
(c)  The Company's Current Reports on Form 8-K filed on January 22, 2010, March 2, 2010, April 16, 2010 (other
than portions of such document deemed not to be filed), April 21, 2010, May 24, 2010 and July 22, 2010;
(d)  The description of the Company's Common Stock contained in the Company's Registration Statement on
Form　8-A filed with the Commission on May 23, 1994, including any amendment or report filed with the Commission
for the purpose of updating such description.
In addition, all documents filed by the Company with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d)
of the Securities Exchange Act of 1934, as amended (the "
Exchange Act
") (other than portions of such
documents deemed not to be filed) after the date of this Registration Statement and prior to the filing of a post-effective
amendment which indicates that all securities registered hereby have been sold or which deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof
from the date of the filing of such documents.
Item 4.		Description of Securities.
Not applicable.
Item 5.		Interests of Named Experts and Counsel.
Not applicable.
Item 6. 		Indemnification of Directors and Officers.
Under Section 145 of the Delaware General Corporation Law, the Company has
broad powers to indemnify its directors and officers against liabilities they may incur in such capacities, including liabilities
under the Securities Act of 1933, as amended (the "
Securities Act
").  The Company's Bylaws also
provide that it will indemnify its directors and executive officers and may indemnify its other officers, employees and other
agents to the fullest extent not prohibited by Delaware law.
The Company's Amended Certificate of Incorporation provides for the elimination of liability for monetary damages for
breach of the directors' fiduciary duty of care to the Company and its stockholders.  These provisions do not eliminate the
directors' duty of care and, in appropriate circumstances, equitable remedies such as injunctive or other forms of non-
monetary relief will remain available under Delaware law.  In addition, each director will continue to be subject to liability for
breach of the director's duty of loyalty to the Company, for acts or omissions not in good faith or involving intentional
misconduct, for knowing violations of law, for any transaction from which the director derived an improper personal benefit
and for payment of dividends or approval of stock repurchases or redemptions that are unlawful under Delaware law.  The
provision does not affect a director's responsibilities under any other laws, such as the federal securities laws or state or
federal environmental laws.
-3-
The Company entered into agreements with its directors and executive officers that require it to indemnify such persons
against expenses, judgments, fines, settlements and other amounts actually and reasonably incurred, including expenses of a
derivative action in connection with any proceeding, whether actual or threatened, to which any such person may be made a
party by reason of the fact that such person is or was a director or officer of the Company or a director or officer of one of its
affiliated enterprises, provided such person acted in good faith and in a manner such person reasonably believed to be in or
not opposed to the Company's best interests and, with respect to any criminal proceeding, had no reasonable cause to
believe his or her conduct was unlawful.  The indemnification agreements also set forth certain procedures that will apply in
the event of a claim for indemnification thereunder.
Item 7.		Exemption from Registration Claimed.
Not applicable.
Item 8.		Exhibits.
Incorporated by Reference
Exhibit
No.
Exhibit
Form
File No.
Filing Date
Exhibit
No.
Filed
Herewith
4.1A
Amended and Restated Certificate of Incorporation of the Registrant.
10-K
000-23272
03/08/2005
3.1A
4.1B
Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Registrant,
dated December 16, 1999.
S-3
333-45274
09/06/2000
3.3
4.1C
Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Registrant,
dated September 30, 2003.
10-K
000-23272
02/10/2004
3.1E
4.2A
Amended and Restated Bylaws of the Registrant.
10-K
000-23272
03/08/2005
3.1A
4.2B
Certificate of Adoption of Amendments to the Amended and Restated Bylaws of the Registrant, dated
February 19, 2003.
10-K
000-23272
03/21/2003
3.2B
4.3
Specimen Common Stock Certificate.
S-1
333-74318
01/21/1994
4.1
5.1
Opinion of Curtis, Mallet-Prevost, Colt & Mosle LLP as to the legality of the shares being registered.
X
23.1
Consent of Curtis, Mallet-Prevost, Colt & Mosle LLP (included in Exhibit 5.1).
X
23.2
Consent of KPMG LLP, Independent Registered Public Accounting Firm.
X
24.1
Power of Attorney (included on the signature page to this Registration Statement on Form S-
8).
X
99.1
NPS Pharmaceuticals, Inc. 2010 Employee Stock Purchase Plan
8-K
000-23272
05/24/2010
10.1
-4-
Item 9.		Undertakings.
The undersigned Company hereby undertakes:
To file, during any period in which offers or sales of the securities registered hereby are being made, a post-effective
amendment to this Registration Statement:
(i) to include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii) to reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the
most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the
information set forth in this Registration Statement.  Notwithstanding the foregoing, any increase or decrease in volume of
securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation
from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the
Commission pursuant to Rule 424(b), if, in the aggregate, the changes in volume and price represent no more than a 20
percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in
the effective Registration Statement; and
(iii) to include any material information with respect to the plan of distribution not previously disclosed in this Registration
Statement or any material change to such information in this Registration Statement; p
rovided
,
however
, that
paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by
those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Company pursuant to
Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be
deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that
time shall be deemed to be the initial
bona fide
offering thereof.
To remove from registration by means of a post-effective amendment any of the securities being registered which remain
unsold at the termination of the offering.
The undersigned Company hereby undertakes that, for purposes of determining any liability under the Securities Act,
each filing of the Company's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated
by reference in this Registration Statement shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering
thereof.
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and
controlling persons of the Company pursuant to the foregoing provisions, or otherwise, the Company has been advised that in
the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is,
therefore unenforceable.  In the event that a claim for indemnification against such liabilities (other than the payment by the
Company of expenses incurred or paid by a director, officer or controlling person of the Company in the successful defense of
any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being
registered, the Company will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit
to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in
the Securities Act and will be governed by the final adjudication of such issue.
-5-
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable
grounds to believe that it meets all of the requirements for filing on Form　S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Bedminster, New Jersey, on this 4th
day of August, 2010.
NPS Pharmaceuticals, Inc.
By:
/s/ Francois Nader
Name:  Francois Nader
Title:  President and Chief Executive Officer
POWER OF ATTORNEY
KNOW BY ALL THESE PRESENTS, that　each person whose signature appears below constitutes and
appoints Edward Stratemeier and  Luke M. Beshar, and each of them acting individually, as his or her true and lawful
attorney-in-fact, with full power of substitution and resubstitution, for him or her and in his or her name, place, and stead, in
any and all capacities, to sign any or all amendments (including post-effective amendments) to this Registration Statement,
and to file the same, with all the exhibits thereto, and other documents in connection therewith, with the Commission, granting
unto said attorneys-in-fact, each acting alone, full power and authority to do and perform each and every act and thing
requisite or necessary to be done in and about the premises as fully, to all intents and purposes, as he or she might or could
do in person, hereby ratifying and confirming all that said attorneys-in-fact, each acting alone, or his substitute or substitutes,
may lawfully do or cause to be done by virtue hereof.  This Power of Attorney may be executed in any number of
counterparts, each of which when so executed and delivered shall be deemed an original and such counterparts shall
together constitute one and the same instrument.  Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Francois Nader
Francois Nader
Director, President and Chief Executive Officer (principal executive officer)
August 4, 2010
/s/ Luke M. Beshar
Luke M. Beshar
Senior Vice President and Chief Financial Officer (principal financial and accounting
officer)
August 4, 2010
/s/ Michael W. Bonney
Michael W. Bonney
Director
August 4, 2010
/s/ Colin Broom
Colin Broom
Director
August 4, 2010
/s/ James G. Groninger
James G. Groninger
Director
August 4, 2010
-6-
/s/ Donald E. Kuhla
Donald E. Kuhla
Director
August 4, 2010
/s/ Rachel R. Selisker
Rachel R. Selisker
Director
August 4, 2010
/s/ Peter G. Tombros
Peter G. Tombros
Chairman of the Board of Directors
August 4, 2010
-7-
EXHIBIT INDEX
Incorporated by Reference
Exhibit
No.
Exhibit
Form
File No.
Filing Date
Exhibit
No.
Filed
Herewith
4.1A
Amended and Restated Certificate of Incorporation of the Registrant.
10-K
000-23272
03/08/2005
3.1A
4.1B
Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Registrant,
dated December 16, 1999.
S-3
333-45274
09/06/2000
3.3
4.1C
Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Registrant,
dated September 30, 2003.
10-K
000-23272
02/10/2004
3.1E
4.2A
Amended and Restated Bylaws of the Registrant.
10-K
000-23272
03/08/2005
3.1A
4.2B
Certificate of Adoption of Amendments to the Amended and Restated Bylaws of the Registrant, dated
February 19, 2003.
10-K
000-23272
03/21/2003
3.2B
4.3
Specimen Common Stock Certificate.
S-1
333-74318
01/21/1994
4.1
5.1
Opinion of Curtis, Mallet-Prevost, Colt & Mosle LLP as to the legality of the shares being registered.
PDF
X
23.1
Consent of Curtis, Mallet-Prevost, Colt & Mosle LLP (included in Exhibit 5.1).
X
23.2
Consent of KPMG LLP, Independent Registered Public Accounting Firm.
PDF
X
24.1
Power of Attorney (included on the signature page to this Registration Statement on Form S-
8).
X
99.1
NPS Pharmaceuticals, Inc. 2010 Employee Stock Purchase Plan
8-K
000-23272
05/24/2010
10.1
-8-