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    <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on May 7, 2025</div>
    <div>
      <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
    </div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">
      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;"></div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
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    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;"> <br>
    </div>
    <div>
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    </div>
    <div style="text-align: center; font-size: 24pt; font-weight: bold;">Immunocore Holdings plc</div>
    <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div>
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    </div>
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          <td style="width: 49.17%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">England and Wales</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom;">&#160;</td>
          <td style="width: 49.16%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Not applicable</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.17%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">(State or other jurisdiction of Incorporation or organization)</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom;">&#160;</td>
          <td style="width: 49.16%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">(I.R.S. Employer Identification No.)</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">92 Park Drive</div>
    <div style="text-align: center; font-weight: bold;">Milton Park</div>
    <div style="text-align: center; font-weight: bold;">Abingdon, Oxfordshire OX14 4RY</div>
    <div style="text-align: center; font-weight: bold;">United Kingdom</div>
    <div style="text-align: center; font-weight: bold;">(Address of principal executive offices) (Zip code)</div>
    <div>
      <div><br>
        <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 20%; color: #000000; text-align: center;"></div>
    </div>
    <div style="text-align: center; font-weight: bold;">Immunocore Holdings plc 2021 Equity Incentive Plan, with Non-Employee Sub-Plan</div>
    <div style="text-align: center; font-weight: bold;">(Full title of the plan)</div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div>
      <div>
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    </div>
    <div style="text-align: center; font-weight: bold;">Immunocore, LLC</div>
    <div style="text-align: center; font-weight: bold;">Six Tower Bridge, Suite 200</div>
    <div style="text-align: center; font-weight: bold;">181 Washington Street</div>
    <div style="text-align: center; font-weight: bold;">Conshohocken, Pennsylvania 19428</div>
    <div style="text-align: center; font-weight: bold;">United States</div>
    <div style="text-align: center; font-weight: bold;">Tel: +1 484 534 5261</div>
    <div style="text-align: center; font-weight: bold;">(Name and address of agent for service) (Telephone number, including area code, of agent for service)</div>
    <div>
      <div><br>
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    </div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">Copies to:</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;"> <br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z97210b43ce9e432ebe751381d903934d" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 31.97%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Divakar Gupta</div>
            <div style="text-align: center; font-weight: bold;">Courtney T. Thorne</div>
            <div style="text-align: center; font-weight: bold;">Cooley LLP</div>
            <div style="text-align: center; font-weight: bold;">55 Hudson Yards</div>
            <div style="text-align: center; font-weight: bold;">New York, New York 10001</div>
            <div style="text-align: center; font-weight: bold;">+1 212 479 6000</div>
          </td>
          <td style="width: 2.02%; vertical-align: middle;">&#160;</td>
          <td style="width: 31.84%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Lily Hepworth</div>
            <div style="text-align: center; font-weight: bold;">General Counsel</div>
            <div style="text-align: center; font-weight: bold;">Immunocore Holdings plc</div>
            <div style="text-align: center; font-weight: bold;">92 Park Drive</div>
            <div style="text-align: center; font-weight: bold;">Milton Park</div>
            <div style="text-align: center; font-weight: bold;">Abingdon, Oxfordshire OX14 4RY</div>
            <div style="text-align: center; font-weight: bold;">United Kingdom</div>
            <div style="text-align: center; font-weight: bold;">Tel: +44 12 3543 8600</div>
          </td>
          <td style="width: 2.02%; vertical-align: middle;">&#160;</td>
          <td style="width: 32.16%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Claire Keast-Butler</div>
            <div style="text-align: center; font-weight: bold;">Cooley (UK) LLP</div>
            <div style="text-align: center; font-weight: bold;">22 Bishopsgate</div>
            <div style="text-align: center; font-weight: bold;">London EC2N 4BQ</div>
            <div style="text-align: center; font-weight: bold;">United Kingdom</div>
            <div style="text-align: center; font-weight: bold;">+44 20 7583 4055</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
      filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div><br>
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        <tr>
          <td style="width: 20.38%; vertical-align: bottom;">
            <div>Large accelerated filer</div>
          </td>
          <td style="width: 1.75%; vertical-align: bottom;">&#160;</td>
          <td style="width: 45.01%; vertical-align: bottom;">
            <div>&#9746;</div>
          </td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 26.28%; vertical-align: bottom;">
            <div>Accelerated filer</div>
          </td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 3.04%; vertical-align: bottom;">
            <div>&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.38%; vertical-align: bottom;">
            <div>Non-accelerated filer</div>
          </td>
          <td style="width: 1.75%; vertical-align: bottom;">&#160;</td>
          <td style="width: 45.01%; vertical-align: bottom;">
            <div>&#9744;</div>
          </td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 26.28%; vertical-align: bottom;">
            <div>Smaller reporting company</div>
          </td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 3.04%; vertical-align: bottom;">
            <div>&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.38%; vertical-align: top;">&#160;</td>
          <td style="width: 1.75%; vertical-align: bottom;">&#160;</td>
          <td style="width: 45.01%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 26.28%; vertical-align: top;">
            <div>Emerging growth company</div>
          </td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 3.04%; vertical-align: top;">
            <div>&#9744;</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. &#9744;</div>
    <div> <br>
    </div>
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    <div style="text-align: center; font-weight: bold;">REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E</div>
    <div>&#160;</div>
    <div style="text-align: justify;"><font style="color: #000000;">Pursuant to General Instruction E to Form S-8, Immunocore Holdings plc (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: #000000;">Registrant</font><font style="color: #000000;">&#8221;) is filing this Registration Statement on Form S-8 with the Securities and Exchange Commission (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: #000000;">Commission</font><font style="color: #000000;">&#8221;) to register 2,466,523</font>&#160;<font style="color: rgb(0, 0, 0);">additional ordinary shares, nominal value &#163;0.002 per share (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: rgb(0, 0, 0);">Ordinary Shares</font><font style="color: rgb(0, 0, 0);">&#8221;), of the Registrant under the Immunocore Holdings plc 2021 Equity Incentive Plan, with Non-Employee Sub Plan (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: rgb(0, 0, 0);">2021 Plan</font><font style="color: rgb(0, 0, 0);">&#8221;), pursuant to the provisions of the 2021 Plan providing for an automatic increase in the number of Ordinary Shares reserved and available for issuance under the 2021 Plan on January 1, 2025. In accordance with the
        instructional note to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of the Form S-8 has been omitted from this Registration Statement.</font></div>
    <div>&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">PART II</div>
    <div>&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div>&#160;</div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" id="z0c9b19f823d44c478b92489a94f96ade" class="DSPFListTable">

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              <div style="text-align: left; color: #000000; font-weight: bold;">ITEM 3.</div>
            </td>
            <td style="text-align: left; vertical-align: top; width: auto;">
              <div style="color: #000000; font-weight: bold;">INCORPORATION OF DOCUMENTS BY REFERENCE</div>
            </td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div style="text-align: justify; color: #000000;">The following documents filed by the Registrant with the Commission are incorporated by reference into this Registration Statement:</div>
    <div>&#160;</div>
    <div style="text-align: justify; color: #000000;">(a) The Registrant&#8217;s Registration Statements on Form S-8, filed with the Commission on <a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121012418/brhc10022952_s8.htm">April 12, 2021</a>
      (File No. 333-255182), <a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036122019491/brhc10037368_s8.htm">May 17, 2022</a> (File No. 333-265000), <a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036123017037/brhc10050696_s8.htm">April 6, 2023</a> (File No. 333-271164), and <a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036124014429/ny20024346x2_s8.htm">March 21,
        2024</a> (File No. 333-278121);</div>
    <div>&#160;</div>
    <div style="text-align: justify; color: #000000;">(b) The Registrant&#8217;s Annual Report on Form <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1671927/000167192725000006/imcr-20241231.htm">10-K</a> for the fiscal year ended December 31, 2024,
      filed with the Commission on February 26, 2025;</div>
    <div>&#160;</div>
    <div style="text-align: justify; color: #000000;">(c) The Registrant&#8217;s Quarterly Report on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1671927/000167192725000009/imcr-20250331.htm">Form 10-Q</a> for the quarterly period ended March 31,
      2025, filed with the Commission on May 7, 2025;</div>
    <div>&#160;</div>
    <div style="text-align: justify; color: #000000;">(d) The Registrant&#8217;s Definitive Proxy Statement on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1671927/000114036125012123/ny20046009x2_def14a.htm">Schedule 14A</a>, filed with the
      Commission on April 4, 2025;</div>
    <div>&#160;</div>
    <div style="text-align: justify; color: #000000;">(e) The Registrant&#8217;s Current Reports on Form 8-K filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1671927/000114036125000008/ef20040795_8k.htm">January 2, 2025</a>
      (excluding Item 7.01 therein), <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1671927/000114036125000837/ef20041400_8k.htm">January 10, 2025</a> (excluding Items 2.02 and 7.01 therein), <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1671927/000114036125005988/ef20044296_8k.htm">February 26, 2025</a> (excluding Item 2.02 therein) and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1671927/000114036125008918/ny20045585x2_8k.htm">March 17, 2025</a>; and</div>
    <div>&#160;</div>
    <div style="text-align: justify; color: #000000;">(f) The description of the Registrant&#8217;s Ordinary Shares and American Depositary Shares contained in the Registrant&#8217;s Registration Statement on Form 8-A, filed with the Commission on <a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121003072/nt10016217x9_8a12b.htm">February 2, 2021</a> (File No. 001-39992) under the Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), including any amendment or report filed for
      the purpose of updating such description, including Exhibit 2.4 to the Registrant&#8217;s Annual Report on Form 20-F for the fiscal year ended December 31, 2020, filed with the Commission on <a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex2-4.htm">March 25, 2021</a>.</div>
    <div>&#160;</div>
    <div style="text-align: justify; color: #000000;">(g) All other reports and documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item
      7.01 of Form 8-K and exhibits furnished on such form that relate to such items) on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all
      securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of the filing of such reports and
      documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained or
      incorporated by reference herein or in any subsequently filed document that also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so
      modified or superseded, to constitute a part of this Registration Statement.</div>
    <div>&#160;</div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; color: #000000; font-weight: normal; font-style: normal;" class="BRPFPageNumber">1</font></div>
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      <div>
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                  <div style="text-align: justify; font-weight: bold;"><font style="font-weight: bold;">ITEM 8.</font></div>
                </td>
                <td style="text-align: left; vertical-align: top; width: auto;">
                  <div style="text-align: justify; font-weight: bold;">EXHIBITS.</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
    </div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" border="0" id="zfa69b4daa27b48beb93c447baa73ac17" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 7.75%; vertical-align: bottom;">&#160;</td>
          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 43.38%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="7">
            <div>
              <div style="text-align: center; font-weight: bold;">Incorporated by Reference</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 7.75%; vertical-align: bottom; border-bottom: 2px solid #000000;">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div>
              <div style="text-align: center; font-weight: bold;">Number</div>
            </div>
          </td>
          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 43.38%; vertical-align: bottom; border-bottom: 2px solid #000000;">
            <div>
              <div style="text-align: center; font-weight: bold;">Description</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Schedule</div>
            <div>
              <div style="text-align: center; font-weight: bold;">Form</div>
            </div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; border-bottom: 2px solid #000000;">
            <div>
              <div style="text-align: center; font-weight: bold;">File Number</div>
            </div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; border-bottom: 2px solid #000000;">
            <div>
              <div style="text-align: center; font-weight: bold;">Exhibit</div>
            </div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 13%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: center; font-weight: bold;">Filing Date</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 7.75%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1671927/000167192724000005/immunocore-amendedarticl.htm">4.1</a></div>
          </td>
          <td style="width: 2.56%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 43.38%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Articles of Association of Immunocore Holdings plc.</div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
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          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-39992</div>
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          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
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          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 13%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
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          <td style="width: 7.75%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex2-2.htm">4.2</a></div>
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          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 43.38%; vertical-align: top;">
            <div>Deposit Agreement.</div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">
            <div style="text-align: center;">20-F</div>
          </td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom;">
            <div style="text-align: center;">001-39992</div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom;">
            <div style="text-align: center;">2.2</div>
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          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 13%; vertical-align: bottom;">
            <div style="text-align: center;">3/25/21</div>
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        </tr>
        <tr>
          <td style="width: 7.75%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex2-2.htm">4.3</a></div>
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          <td style="width: 2.56%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 43.38%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Form of American Depositary Receipt (included in Exhibit 4.2).</div>
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          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">20-F</div>
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          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-39992</div>
          </td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">2.3</div>
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          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 13%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3/25/21</div>
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          <td style="width: 7.75%; vertical-align: top;">
            <div><a href="ef20048500_ex5-1.htm">5.1*</a></div>
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          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 43.38%; vertical-align: top;">
            <div>Opinion of Cooley (UK) LLP.</div>
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          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 13%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7.75%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="ef20048500_ex23-1.htm">23.1*</a></div>
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          <td style="width: 2.56%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 43.38%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Consent of KPMG LLP, the Registrant&#8217;s former independent registered public accounting firm</div>
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          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 13%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
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          <td style="width: 7.75%; vertical-align: top;">
            <div><a href="ef20048500_ex23-2.htm">23.2*</a></div>
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          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 43.38%; vertical-align: top;">
            <div>Consent of Deloitte LLP, the Registrant&#8217;s independent registered public accounting firm</div>
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          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 13%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 7.75%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="ef20048500_ex5-1.htm">23.3*</a></div>
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          <td style="width: 2.56%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 43.38%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Consent of Cooley (UK) LLP (included in Exhibit 5.1).</div>
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          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 13%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
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          <td style="width: 7.75%; vertical-align: top;">
            <div><a href="#POWEROFATTORNEY">24.1*</a></div>
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          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 43.38%; vertical-align: top;">
            <div>Power of Attorney (included on the signature page of this Registration Statement)</div>
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          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 13%; vertical-align: bottom;">&#160;</td>
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        <tr>
          <td style="width: 7.75%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex4-20.htm">99.1</a></div>
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          <td style="width: 2.56%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 43.38%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Immunocore Holdings plc 2021 Equity Incentive Plan, with Non-Employee Sub-Plan.</div>
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          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">20-F</div>
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          <td style="width: 1.52%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-39992</div>
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          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.20</div>
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          <td style="width: 1.54%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 13%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3/25/21</div>
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        <tr>
          <td style="width: 7.75%; vertical-align: top;">
            <div><a href="ef20048500_ex107.htm">107*</a></div>
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          <td style="width: 2.56%; vertical-align: bottom;">&#160;</td>
          <td style="width: 43.38%; vertical-align: top;">
            <div>Filing Fee Table</div>
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          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 9.96%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.54%; vertical-align: bottom;">&#160;</td>
          <td style="width: 13%; vertical-align: bottom;">&#160;</td>
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            <div>Filed herewith.</div>
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            <div style="font-weight: bold;">IMMUNOCORE HOLDINGS PLC</div>
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          <td style="width: 49.9%; vertical-align: top;">&#160;</td>
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          <td style="width: 46.9%; vertical-align: middle;">&#160;</td>
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            <div>/s/ Bahija Jallal, Ph.D.</div>
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            <div>Name: Bahija Jallal, Ph.D.</div>
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            <div>Title: Chief Executive Officer</div>
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    <div style="text-align: justify; text-indent: 18pt;">KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Bahija Jallal, Travis Coy and Lily Hepworth, and each or any one of them, his or her true
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          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 13%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
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          <td style="width: 26.72%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 58%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
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          <td style="width: 26.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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          <td style="width: 58%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Chief Executive Officer and Director</div>
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            <div style="text-align: right; color: rgb(0, 0, 0);">May 7, 2025</div>
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            <div>Bahija Jallal, Ph.D.</div>
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          <td style="width: 58%; vertical-align: top;">
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          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 13%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 26.72%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 58%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 13%; vertical-align: middle;">&#160;</td>
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          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 58%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Chief Financial Officer</div>
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          <td style="width: 1%; vertical-align: top;">&#160;</td>
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          <td style="width: 58%; vertical-align: top;">
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          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 13%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 26.72%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 58%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 13%; vertical-align: top;">&#160;</td>
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          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 58%; vertical-align: top;">
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          <td style="width: 1%; vertical-align: top;">&#160;</td>
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            <div style="color: rgb(0, 0, 0);">John Goll</div>
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          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 58%; vertical-align: top;">
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          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 13%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 26.72%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 58%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 13%; vertical-align: top;">&#160;</td>
        </tr>
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          <td style="width: 26.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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    <div style="text-align: center; font-weight: bold;">SIGNATURE OF AUTHORIZED U.S. REPRESENTATIVE</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 18pt;">Pursuant to the Securities Act of 1933, the undersigned, the duly authorized representative in the United States of Immunocore Holdings plc has signed this registration statement or amendment thereto
      on May 7, 2025.</div>
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            <div>By:</div>
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            <div>/s/ Bahija Jallal, Ph.D.</div>
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[{"type": "S-8", "sequence": "1", "filename": "ef20048500_s8.htm", "description": "S-8", "secsgml_size_bytes": 63999}]
{"company-data": {"conformed-name": "Immunocore Holdings plc", "cik": "0001671927", "assigned-sic": "2836", "organization-name": "03 Life Sciences", "ein": "000000000", "state-of-incorporation": "X0", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-287041", "film-number": "25922092"}, "business-address": {"street1": "90 PARK DRIVE", "street2": "MILTON PARK, ABINGDON", "city": "OXFORDSHIRE", "state": "X0", "zip": "OX14 4RY", "phone": "01235 5430281"}, "mail-address": {"street1": "90 PARK DRIVE", "street2": "MILTON PARK, ABINGDON", "city": "OXFORDSHIRE", "state": "X0", "zip": "OX14 4RY"}, "former-company": {"former-conformed-name": "Immunocore Ltd", "date-changed": "20160412"}}
As filed with the Securities and Exchange Commission on May 7, 2025
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Immunocore Holdings plc
(Exact name of registrant as specified in its charter)
England and Wales
Not applicable
(State or other jurisdiction of Incorporation or organization)
(I.R.S. Employer Identification No.)
92 Park Drive
Milton Park
Abingdon, Oxfordshire OX14 4RY
United Kingdom
(Address of principal executive offices) (Zip code)
Immunocore Holdings plc 2021 Equity Incentive Plan, with Non-Employee Sub-Plan
(Full title of the plan)
Immunocore, LLC
Six Tower Bridge, Suite 200
181 Washington Street
Conshohocken, Pennsylvania 19428
United States
Tel: +1 484 534 5261
(Name and address of agent for service) (Telephone number, including area code, of agent for service)
Copies to:
Divakar Gupta
Courtney T. Thorne
Cooley LLP
55 Hudson Yards
New York, New York 10001
+1 212 479 6000
Lily Hepworth
General Counsel
Immunocore Holdings plc
92 Park Drive
Milton Park
Abingdon, Oxfordshire OX14 4RY
United Kingdom
Tel: +44 12 3543 8600
Claire Keast-Butler
Cooley (UK) LLP
22 Bishopsgate
London EC2N 4BQ
United Kingdom
+44 20 7583 4055
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
      filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☒
Accelerated filer
☐
Non-accelerated filer
☐
Smaller reporting company
☐
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. ☐
REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E
Pursuant to General Instruction E to Form S-8, Immunocore Holdings plc (the "
Registrant
") is filing this Registration Statement on Form S-8 with the Securities and Exchange Commission (the "
Commission
") to register 2,466,523
additional ordinary shares, nominal value £0.002 per share (the "
Ordinary Shares
"), of the Registrant under the Immunocore Holdings plc 2021 Equity Incentive Plan, with Non-Employee Sub Plan (the "
2021 Plan
"), pursuant to the provisions of the 2021 Plan providing for an automatic increase in the number of Ordinary Shares reserved and available for issuance under the 2021 Plan on January 1, 2025. In accordance with the
        instructional note to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of the Form S-8 has been omitted from this Registration Statement.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
ITEM 3.
INCORPORATION OF DOCUMENTS BY REFERENCE
The following documents filed by the Registrant with the Commission are incorporated by reference into this Registration Statement:
(a) The Registrant's Registration Statements on Form S-8, filed with the Commission on
April 12, 2021
(File No. 333-255182),
May 17, 2022
(File No. 333-265000),
April 6, 2023
(File No. 333-271164), and
March 21,
        2024
(File No. 333-278121);
(b) The Registrant's Annual Report on Form
10-K
for the fiscal year ended December 31, 2024,
      filed with the Commission on February 26, 2025;
(c) The Registrant's Quarterly Report on
Form 10-Q
for the quarterly period ended March 31,
      2025, filed with the Commission on May 7, 2025;
(d) The Registrant's Definitive Proxy Statement on
Schedule 14A
, filed with the
      Commission on April 4, 2025;
(e) The Registrant's Current Reports on Form 8-K filed with the SEC on
January 2, 2025
(excluding Item 7.01 therein),
January 10, 2025
(excluding Items 2.02 and 7.01 therein),
February 26, 2025
(excluding Item 2.02 therein) and
March 17, 2025
; and
(f) The description of the Registrant's Ordinary Shares and American Depositary Shares contained in the Registrant's Registration Statement on Form 8-A, filed with the Commission on
February 2, 2021
(File No. 001-39992) under the Exchange Act of 1934, as amended (the "Exchange Act"), including any amendment or report filed for
      the purpose of updating such description, including Exhibit 2.4 to the Registrant's Annual Report on Form 20-F for the fiscal year ended December 31, 2020, filed with the Commission on
March 25, 2021
.
(g) All other reports and documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item
      7.01 of Form 8-K and exhibits furnished on such form that relate to such items) on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all
      securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of the filing of such reports and
      documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained or
      incorporated by reference herein or in any subsequently filed document that also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so
      modified or superseded, to constitute a part of this Registration Statement.
1
ITEM 8.
EXHIBITS.
Incorporated by Reference
Exhibit
Number
Description
Schedule
Form
File Number
Exhibit
Filing Date
4.1
Articles of Association of Immunocore Holdings plc.
10-Q
001-39992
3.1
8/8/24
4.2
Deposit Agreement.
20-F
001-39992
2.2
3/25/21
4.3
Form of American Depositary Receipt (included in Exhibit 4.2).
20-F
001-39992
2.3
3/25/21
5.1*
Opinion of Cooley (UK) LLP.
23.1*
Consent of KPMG LLP, the Registrant's former independent registered public accounting firm
23.2*
Consent of Deloitte LLP, the Registrant's independent registered public accounting firm
23.3*
Consent of Cooley (UK) LLP (included in Exhibit 5.1).
24.1*
Power of Attorney (included on the signature page of this Registration Statement)
99.1
Immunocore Holdings plc 2021 Equity Incentive Plan, with Non-Employee Sub-Plan.
20-F
001-39992
4.20
3/25/21
107*
Filing Fee Table
*
Filed herewith.
2
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
      and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Oxford, United Kingdom, on the seventh day of May, 2025.
IMMUNOCORE HOLDINGS PLC
By:
/s/ Bahija Jallal, Ph.D.
Name: Bahija Jallal, Ph.D.
Title: Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Bahija Jallal, Travis Coy and Lily Hepworth, and each or any one of them, his or her true
      and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this
      Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and
      authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said
      attorneys-in-fact and agents, or any of them, or their or his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
1
SIGNATURE
TITLE
DATE
/s/ Bahija Jallal, Ph.D.
Chief Executive Officer and Director
May 7, 2025
Bahija Jallal, Ph.D.
(Principal Executive Officer)
/s/ Travis Coy
Chief Financial Officer
May 7, 2025
Travis Coy
(Principal Financial Officer)
/s/ John Goll
SVP, Finance & Chief Accounting Officer
May 7, 2025
John Goll
(Principal Accounting Officer)
/s/ Professor Sir John Bell
Chairman of the Board of Directors
May 7, 2025
Professor Sir John Bell
/s/ Roy S. Herbst, M.D., Ph.D.
Director
May 7, 2025
Roy S. Herbst, M.D., Ph.D.
/s/ Siddharth Kaul
Director
May 7, 2025
Siddharth Kaul
/s/ Mr. Ranjeev Krishana
Director
May 7, 2025
Mr. Ranjeev Krishana
/s/ Dr. William Pao, M.D., Ph.D.
Director
May 7, 2025
Dr. William Pao, M.D., Ph.D.
/s/ Robert Perez
Director
May 7, 2025
Robert Perez
/s/ Kristine Peterson
Director
May 7, 2025
Kristine Peterson
/s/ Professor Sir Peter Ratcliffe
Director
May 7, 2025
Professor Sir Peter Ratcliffe
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SIGNATURE OF AUTHORIZED U.S. REPRESENTATIVE
Pursuant to the Securities Act of 1933, the undersigned, the duly authorized representative in the United States of Immunocore Holdings plc has signed this registration statement or amendment thereto
      on May 7, 2025.
IMMUNOCORE, LLC
By:
/s/ Bahija Jallal, Ph.D.
Name: Bahija Jallal, Ph.D.
Title: Authorized Signatory
3