<PAGE>



     AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON OCTOBER 1, 2004

                                                    REGISTRATION NO. 333-_______
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                ----------------

                                    FORM S-8
                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933
                                ----------------

                         PROGENICS PHARMACEUTICALS, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

<TABLE>
<S>                                 <C>                                                         <C>
            DELAWARE                            777 OLD SAW MILL RIVER ROAD                          13-3379479
(STATE OR OTHER JURISDICTION OF                  TARRYTOWN, NEW YORK 10591                        (I.R.S. EMPLOYER
 INCORPORATION OR ORGANIZATION)     (ADDRESS OF PRINCIPAL EXECUTIVE OFFICES) (ZIP CODE)         IDENTIFICATION NO.)
</TABLE>
                                ----------------

                        1998 EMPLOYEE STOCK PURCHASE PLAN
                 1998 NON-QUALIFIED EMPLOYEE STOCK PURCHASE PLAN
                            (FULL TITLE OF THE PLAN)
                                ----------------

                           PAUL J. MADDON, M.D., PH.D.
                CHAIRMAN OF THE BOARD AND CHIEF EXECUTIVE OFFICER
                         PROGENICS PHARMACEUTICALS, INC.
                             777 SAW MILL RIVER ROAD
                            TARRYTOWN, NEW YORK 10591
                     (Name and address of agent for service)

                                -----------------

          TELEPHONE NUMBER, INCLUDING AREA CODE, OF AGENT FOR SERVICE:
                                 (914) 789-2800

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
=======================================================================================================================
    TITLE OF EACH CLASS OF            AMOUNT          PROPOSED MAXIMUM      PROPOSED MAXIMUM
          SECURITIES                  TO BE            OFFERING PRICE      AGGREGATE OFFERING        AMOUNT OF
       TO BE REGISTERED          REGISTERED(1)(2)       PER SHARE(3)            PRICE(3)         REGISTRATION FEE
-----------------------------------------------------------------------------------------------------------------------
<S>                              <C>                  <C>                  <C>                   <C>

Common Stock, $0.0013 par
value per share                     1,100,000             $12.32_             $13,552,000             $1,717
=======================================================================================================================
</TABLE>
(1)  Represents 850,000 shares issuable upon exercise of options to be
     granted pursuant to the 1998 Employee Stock Purchase Plan and 250,000
     shares issuable upon exercise of options to be granted pursuant to the
     1998 Non-Qualified Employee Stock Purchase Plan.
(2)  Plus such additional shares as may be issued by reason of stock splits,
     stock dividends or similar transactions.
(3)  Pursuant to Rules 457(h) and 457(c), these prices are estimated solely
     for the purpose of calculating the registration fee and are based upon
     the average of the high and low sales prices of the Registrant's common
     stock on the Nasdaq National Market on September 27, 2004.

<PAGE>

                              EXPLANATORY STATEMENT

                  This Form S-8 Registration Statement is being filed with the
Securities and Exchange Commission (the "Commission") by Progenics
Pharmaceuticals, Inc., a Delaware corporation (the "Company"), in order to
register 1,100,000 shares of the Company's common stock, par value $0.0013 per
share (the "Common Stock"), issuable upon exercise of options granted or to be
granted under the Company's 1998 Employee Stock Purchase Plan and the 1998
Non-Qualified Employee Stock Purchase Plan (the "Plans"). On June 11, 1998, the
Company filed with the Commission a Registration Statement on Form S-8
(Registration No. 333-56571) registering up to 200,000 shares of Common Stock
issuable under the Plans (the "Initial Registration Statement"). With the
addition of 1,100,000 shares pursuant to this Registration Statement, the total
number of shares now registered for issuance pursuant to the Plans is 1,300,000.
Pursuant to General Instruction E of Form S-8, the Company hereby incorporates
by reference in this Registration Statement all contents of the Initial
Registration Statement, including the exhibits thereto.


                                     PART I


              INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS


                  The information specified in Item 1 and Item 2 of Part I of
this Registration Statement on Form S-8 (the "Registration Statement") is
omitted from this filing in accordance with the provisions of Rule 428 under the
Securities Act of 1933, as amended. The documents containing the information
specified in Part I will be delivered to the participants in the plan covered by
this Registration Statement as required by Rule 428.

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.           INCORPORATION OF DOCUMENTS BY REFERENCE.

                  The following documents filed with the Commission are hereby
incorporated by reference:

                  a)       The Registrant's Annual Report on Form 10-K for the
                           fiscal year ended December 31, 2003;

                  b)       The Registrant's Quarterly Reports on Form 10-Q for
                           the quarters ended March 31, 2004 and June 30, 2004;
                           and

                  c)       The description of the Company's Common Stock in the
                           Registrant's registration statement on Form 8-A dated
                           September 29, 1997, File No. 0-23143 pursuant to
                           Section 12 of the Securities Exchange Act of 1934, as
                           amended (the "Exchange Act") including all amendments
                           or reports filed with the Commission for the purpose
                           of updating such description.

                  All other documents subsequently filed by the Registrant
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the
filing of a post-effective amendment which indicates that all securities offered
hereunder have been sold or which deregisters all such securities then remaining
unsold shall be deemed to be incorporated by reference in this Registration
Statement and be a part hereof from the date of filing of such documents.

                  Any statement contained herein or in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified
or superseded for purposes of this Registration Statement to the extent that a
statement contained herein or in any other subsequently filed document which
also is or is deemed to be incorporated by reference herein modifies or
supersedes such earlier statement. Any statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this
Registration Statement.


<PAGE>

ITEM 4.           DESCRIPTION OF SECURITIES.

                  Not applicable.

ITEM 5.           INTERESTS OF NAMED EXPERTS AND COUNSEL.

                  Not applicable.

ITEM 6.           INDEMNIFICATION OF DIRECTORS AND OFFICERS.

                  Section 145(a) of the General Corporation Law of the State of
Delaware (the "DGCL") provides that a Delaware corporation may indemnify any
person who was or is a party or is threatened to be made a party to any
threatened, pending or completed action, suit or proceeding, whether civil,
criminal, administrative or investigative (other than an action by or in the
right of the corporation) by reason of the fact that he is or was a director,
officer, employee or agent of the corporation or is or was serving at the
request of the corporation as a director, officer, employee or agent of another
corporation or enterprise, against expenses, judgments, fines and amounts paid
in settlement actually and reasonably incurred by him in connection with such
action, suit or proceeding if he acted in good faith and in a manner he
reasonably believed to be in or not opposed to the best interests of the
corporation, and, with respect to any criminal action or proceeding, had no
cause to believe his conduct was unlawful.

                  Section 145(b) of the DGCL provides that a Delaware
corporation may indemnify any person who was or is a party or is threatened to
be made a party to any threatened, pending or completed action or suit by or in
the right of the corporation to procure a judgment in its favor by reason of the
fact that such person acted in any of the capacities set forth above, against
expenses actually and reasonably incurred by him in connection with the defense
or settlement of such action or suit if he acted under similar standards, except
that no indemnification may be made in respect of any claim, issue or matter as
to which such person shall have been adjudged to be liable to the corporation
unless and only to the extent that the court in which such action or suit was
brought shall determine that despite the adjudication of liability, such person
is fairly and reasonably entitled to be indemnified for such expenses which the
court shall deem proper.

                  Section 145 of the DGCL further provides that to the extent a
director or officer of a corporation has been successful in the defense of any
action, suit or proceeding referred to in subsections (a) and (b) or in the
defense of any claim, issue, or matter therein, he shall be indemnified against
expenses actually and reasonably incurred by him in connection therewith; that
indemnification provided for by Section 145 shall not be deemed exclusive of any
other rights to which the indemnified party may be entitled; and that the
corporation may purchase and maintain insurance on behalf of a director or
officer of the corporation against any liability asserted against him or
incurred by him in any such capacity or arising out of his status as such
whether or not the corporation would have the power to indemnify him against
such liabilities under such Section 145.

                  Section 102(b)(7) of the DGCL provides that a corporation in
its original certificate of incorporation or an amendment thereto validly
approved by stockholders may eliminate or limit personal liability of members of
its board of directors or governing body for breach of a director's fiduciary
duty. However, no such provision may eliminate or limit the liability of a
director for breaching his duty of loyalty, failing to act in good faith,
engaging in intentional misconduct or knowingly violating a law, paying a
dividend or approving a stock repurchase which was illegal, or obtaining an
improper personal benefit. A provision of this type has no effect on the
availability of equitable remedies, such as injunction or rescission, for breach
of fiduciary duty. The Registrant's Restated Certificate of Incorporation
contains such a provision.

                  The Registrant's Certificate of Incorporation and By-Laws
provide that the Registrant shall indemnify officers and directors, and to the
extent authorized by the Board of Directors, employees and agents of the
Registrant, to the full extent permitted by and in the manner permissible under
the laws of the State of Delaware. In addition, the By-Laws permit the Board of
Directors to authorize the Registrant to purchase and maintain insurance against
any liability asserted against any director, officer, employee or agent of the
Registrant arising out of his capacity as such.


                                       2
<PAGE>

                  The Registrant has entered into Indemnification Agreements
with each of its officers and directors, pursuant to which the Registrant has
agreed to indemnify and advance expenses to such officers and directors to the
fullest extent permitted by applicable law.

                  The Registrant has obtained an insurance policy providing
coverage for certain liabilities of its officers and directors.

ITEM 7.           EXEMPTION FROM REGISTRATION CLAIMED.

          Not applicable.

ITEM 8.           EXHIBITS.

                  The following documents are filed as Exhibits hereto:

<TABLE>
<CAPTION>
  EXHIBIT
  NUMBER             DESCRIPTION
  -------            -----------
<S>                  <C>                                                             <C>
  3.1                Certificate of Incorporation of the Company, as amended         Incorporated by reference
                                                                                     from Exhibit 3.1 to the
                                                                                     Company's Form S-1
                                                                                     Registration Statement No.
                                                                                     333-13627 dated November 19,
                                                                                     1997
  5.1                Opinion and Consent of Dewey Ballantine LLP with respect to     Filed herewith
                     the legality of the securities being registered
  10.1               1998 Employee Stock Purchase Plan                               Filed herewith
  10.2               1998 Non-Qualified Employee Stock Purchase Plan                 Filed herewith
  23.1               Consent of Dewey Ballantine LLP (contained in their opinion     Filed herewith
                     filed herewith as Exhibit 5.1)
  23.2               Consent of PricewaterhouseCoopers LLP                           Filed herewith
  24.1               Power of Attorney of directors and certain officers of the      Filed herewith
                     Company (included in Signature Page)
</TABLE>

ITEM 9.   UNDERTAKINGS.

a)  The undersigned registrant hereby undertakes:

    (1) To file, during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:

        (i) To include any prospectus required by section 10(a)(3) of
the Securities Act of 1933;


                                       3
<PAGE>

        (ii) To reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that
which was registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
changes in volume and price represent no more than a 20 percent change in the
maximum aggregate offering price set forth in the "Calculation of Registration
Fee" table in the effective registration statement;

        (iii) To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement;

provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
registration statement is on Form S-3, Form S-8 of Form F-3, and the information
required to be included in a post-effective amendment by those paragraphs is
contained in periodic reports filed with or furnished to the Commission by the
registrant pursuant to Section 13 or 15(d) of the Securities Exchange Act of
1934 that are incorporated by reference in the registration statement.

        (2) That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

        (3) To remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the termination of
the offering.

b) The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 that is incorporated by reference in the
Registration Statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

c) Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Act and is,
therefore, unenforceable. In the event that a claim for indemnification against
such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.


                                       4
<PAGE>

                                   SIGNATURES

        The Registrant. Pursuant to the requirements of the Securities Act of
1933, the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Tarrytown, State of New York, on September 30,
2004.

                        PROGENICS PHARMACEUTICALS, INC.

                        By:  /s/ PAUL J. MADDON, M.D., PH.D.
                             -------------------------------
                             Paul J. Maddon, M.D., Ph.D.
                             Chairman of the Board and Chief Executive Officer


                                POWER OF ATTORNEY

                  KNOW ALL PERSONS BY THESE PRESENTS, that each of the persons
whose names appear below constitute and appoint Paul J. Maddon, M.D., Ph.D.,
Ronald J. Prentki and Robert A. McKinney, and each of them, as his true and
lawful attorney-in-fact and agent, with full power of substitution and
resubstitution, for him and in his name, place and stead, in any and all
capacities, to execute any and all amendments to this Registration Statement,
and to file the same, together with all exhibits thereto, and other documents in
connection therewith, with the Securities and Exchange Commission, and such
other agencies, offices and persons as may be required by applicable law,
granting unto said attorney-in-fact and agent, full power and authority to do
and perform each and every act and thing requisite or necessary to be done in
and about the premises, as fully to all intents and purposes as he or she might
or could do in person, hereby ratifying and confirming all that each said
attorney-in-fact and agent may lawfully do or cause to be done by virtue hereof.

                  Pursuant to the requirements of the Securities Act of 1933,
this Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>

        Signature                                Capacity                                           Date
        ---------                                --------                                           ----
<S>                                              <C>                                                <C>
/s/ PAUL J. MADDON, M.D., PH.D.                  Chairman of the Board and Chief Executive          September 30, 2004
-------------------------------                  Officer (Principal Executive Officer)
Paul J. Maddon, M.D., Ph.D.

/s/ ROBERT A. MCKINNEY                           Vice President, Finance & Operations and           September 30, 2004
-----------------------                          Treasurer (Principal Financial and
Robert A. McKinney                               Accounting Officer)

/s/ CHARLES A. BAKER                             Director                                           September 30, 2004
--------------------
Charles A. Baker

/s/ KURT W. BRINER                               Director                                           September 30, 2004
------------------
Kurt W. Briner

/s/ MARK F. DALTON                               Director                                           September 30, 2004
------------------
Mark F. Dalton

/s/ STEPHEN P. GOFF, PH.D.                       Director                                           September 29, 2004
--------------------------
Stephen P. Goff, Ph.D.

/s/ PAUL F. JACOBSON                             Director                                           September 30, 2004
--------------------
Paul F. Jacobson

/s/ RONALD J. PRENTKI                            President and Director                             September 30, 2004
---------------------
Ronald J. Prentki

/s/ DAVID A. SCHEINBERG, M.D., PH.D.             Director                                           September 30, 2004
------------------------------------
David A. Scheinberg, M.D., Ph.D.
</TABLE>


                                       5
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{"company-data": {"conformed-name": "PROGENICS PHARMACEUTICALS INC", "cik": "0000835887", "assigned-sic": "2834", "irs-number": "133379479", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-119463", "film-number": "041058309"}, "business-address": {"street1": "777 OLD SAW MILL RIVER ROAD", "city": "TARRYTOWN", "state": "NY", "zip": "10591", "phone": "9147892800"}, "mail-address": {"street1": "777 OLD SAW MILL RIVER ROAD", "city": "TARRYTOWN", "state": "NY", "zip": "10591"}}
AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON OCTOBER 1, 2004

                                                    REGISTRATION NO. 333-_______
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                ----------------

                                    FORM S-8
                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933
                                ----------------

                         PROGENICS PHARMACEUTICALS, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
DELAWARE                            777 OLD SAW MILL RIVER ROAD                          13-3379479
(STATE OR OTHER JURISDICTION OF                  TARRYTOWN, NEW YORK 10591                        (I.R.S. EMPLOYER
 INCORPORATION OR ORGANIZATION)     (ADDRESS OF PRINCIPAL EXECUTIVE OFFICES) (ZIP CODE)         IDENTIFICATION NO.)
----------------

                        1998 EMPLOYEE STOCK PURCHASE PLAN
                 1998 NON-QUALIFIED EMPLOYEE STOCK PURCHASE PLAN
                            (FULL TITLE OF THE PLAN)
                                ----------------

                           PAUL J. MADDON, M.D., PH.D.
                CHAIRMAN OF THE BOARD AND CHIEF EXECUTIVE OFFICER
                         PROGENICS PHARMACEUTICALS, INC.
                             777 SAW MILL RIVER ROAD
                            TARRYTOWN, NEW YORK 10591
                     (Name and address of agent for service)

                                -----------------

          TELEPHONE NUMBER, INCLUDING AREA CODE, OF AGENT FOR SERVICE:
                                 (914) 789-2800

                         CALCULATION OF REGISTRATION FEE
=======================================================================================================================
    TITLE OF EACH CLASS OF            AMOUNT          PROPOSED MAXIMUM      PROPOSED MAXIMUM
          SECURITIES                  TO BE            OFFERING PRICE      AGGREGATE OFFERING        AMOUNT OF
       TO BE REGISTERED          REGISTERED(1)(2)       PER SHARE(3)            PRICE(3)         REGISTRATION FEE
-----------------------------------------------------------------------------------------------------------------------
Common Stock, $0.0013 par
value per share                     1,100,000             $12.32_             $13,552,000             $1,717
=======================================================================================================================
(1)  Represents 850,000 shares issuable upon exercise of options to be
     granted pursuant to the 1998 Employee Stock Purchase Plan and 250,000
     shares issuable upon exercise of options to be granted pursuant to the
     1998 Non-Qualified Employee Stock Purchase Plan.
(2)  Plus such additional shares as may be issued by reason of stock splits,
     stock dividends or similar transactions.
(3)  Pursuant to Rules 457(h) and 457(c), these prices are estimated solely
     for the purpose of calculating the registration fee and are based upon
     the average of the high and low sales prices of the Registrant's common
     stock on the Nasdaq National Market on September 27, 2004.
EXPLANATORY STATEMENT

                  This Form S-8 Registration Statement is being filed with the
Securities and Exchange Commission (the "Commission") by Progenics
Pharmaceuticals, Inc., a Delaware corporation (the "Company"), in order to
register 1,100,000 shares of the Company's common stock, par value $0.0013 per
share (the "Common Stock"), issuable upon exercise of options granted or to be
granted under the Company's 1998 Employee Stock Purchase Plan and the 1998
Non-Qualified Employee Stock Purchase Plan (the "Plans"). On June 11, 1998, the
Company filed with the Commission a Registration Statement on Form S-8
(Registration No. 333-56571) registering up to 200,000 shares of Common Stock
issuable under the Plans (the "Initial Registration Statement"). With the
addition of 1,100,000 shares pursuant to this Registration Statement, the total
number of shares now registered for issuance pursuant to the Plans is 1,300,000.
Pursuant to General Instruction E of Form S-8, the Company hereby incorporates
by reference in this Registration Statement all contents of the Initial
Registration Statement, including the exhibits thereto.

                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS

                  The information specified in Item 1 and Item 2 of Part I of
this Registration Statement on Form S-8 (the "Registration Statement") is
omitted from this filing in accordance with the provisions of Rule 428 under the
Securities Act of 1933, as amended. The documents containing the information
specified in Part I will be delivered to the participants in the plan covered by
this Registration Statement as required by Rule 428.

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.           INCORPORATION OF DOCUMENTS BY REFERENCE.

                  The following documents filed with the Commission are hereby
incorporated by reference:

                  a)       The Registrant's Annual Report on Form 10-K for the
                           fiscal year ended December 31, 2003;

                  b)       The Registrant's Quarterly Reports on Form 10-Q for
                           the quarters ended March 31, 2004 and June 30, 2004;
                           and

                  c)       The description of the Company's Common Stock in the
                           Registrant's registration statement on Form 8-A dated
                           September 29, 1997, File No. 0-23143 pursuant to
                           Section 12 of the Securities Exchange Act of 1934, as
                           amended (the "Exchange Act") including all amendments
                           or reports filed with the Commission for the purpose
                           of updating such description.

                  All other documents subsequently filed by the Registrant
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the
filing of a post-effective amendment which indicates that all securities offered
hereunder have been sold or which deregisters all such securities then remaining
unsold shall be deemed to be incorporated by reference in this Registration
Statement and be a part hereof from the date of filing of such documents.

                  Any statement contained herein or in a document incorporated
or deemed to be incorporated by reference herein shall be deemed to be modified
or superseded for purposes of this Registration Statement to the extent that a
statement contained herein or in any other subsequently filed document which
also is or is deemed to be incorporated by reference herein modifies or
supersedes such earlier statement. Any statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this
Registration Statement.
ITEM 4.           DESCRIPTION OF SECURITIES.

                  Not applicable.

ITEM 5.           INTERESTS OF NAMED EXPERTS AND COUNSEL.

                  Not applicable.

ITEM 6.           INDEMNIFICATION OF DIRECTORS AND OFFICERS.

                  Section 145(a) of the General Corporation Law of the State of
Delaware (the "DGCL") provides that a Delaware corporation may indemnify any
person who was or is a party or is threatened to be made a party to any
threatened, pending or completed action, suit or proceeding, whether civil,
criminal, administrative or investigative (other than an action by or in the
right of the corporation) by reason of the fact that he is or was a director,
officer, employee or agent of the corporation or is or was serving at the
request of the corporation as a director, officer, employee or agent of another
corporation or enterprise, against expenses, judgments, fines and amounts paid
in settlement actually and reasonably incurred by him in connection with such
action, suit or proceeding if he acted in good faith and in a manner he
reasonably believed to be in or not opposed to the best interests of the
corporation, and, with respect to any criminal action or proceeding, had no
cause to believe his conduct was unlawful.

                  Section 145(b) of the DGCL provides that a Delaware
corporation may indemnify any person who was or is a party or is threatened to
be made a party to any threatened, pending or completed action or suit by or in
the right of the corporation to procure a judgment in its favor by reason of the
fact that such person acted in any of the capacities set forth above, against
expenses actually and reasonably incurred by him in connection with the defense
or settlement of such action or suit if he acted under similar standards, except
that no indemnification may be made in respect of any claim, issue or matter as
to which such person shall have been adjudged to be liable to the corporation
unless and only to the extent that the court in which such action or suit was
brought shall determine that despite the adjudication of liability, such person
is fairly and reasonably entitled to be indemnified for such expenses which the
court shall deem proper.

                  Section 145 of the DGCL further provides that to the extent a
director or officer of a corporation has been successful in the defense of any
action, suit or proceeding referred to in subsections (a) and (b) or in the
defense of any claim, issue, or matter therein, he shall be indemnified against
expenses actually and reasonably incurred by him in connection therewith; that
indemnification provided for by Section 145 shall not be deemed exclusive of any
other rights to which the indemnified party may be entitled; and that the
corporation may purchase and maintain insurance on behalf of a director or
officer of the corporation against any liability asserted against him or
incurred by him in any such capacity or arising out of his status as such
whether or not the corporation would have the power to indemnify him against
such liabilities under such Section 145.

                  Section 102(b)(7) of the DGCL provides that a corporation in
its original certificate of incorporation or an amendment thereto validly
approved by stockholders may eliminate or limit personal liability of members of
its board of directors or governing body for breach of a director's fiduciary
duty. However, no such provision may eliminate or limit the liability of a
director for breaching his duty of loyalty, failing to act in good faith,
engaging in intentional misconduct or knowingly violating a law, paying a
dividend or approving a stock repurchase which was illegal, or obtaining an
improper personal benefit. A provision of this type has no effect on the
availability of equitable remedies, such as injunction or rescission, for breach
of fiduciary duty. The Registrant's Restated Certificate of Incorporation
contains such a provision.

                  The Registrant's Certificate of Incorporation and By-Laws
provide that the Registrant shall indemnify officers and directors, and to the
extent authorized by the Board of Directors, employees and agents of the
Registrant, to the full extent permitted by and in the manner permissible under
the laws of the State of Delaware. In addition, the By-Laws permit the Board of
Directors to authorize the Registrant to purchase and maintain insurance against
any liability asserted against any director, officer, employee or agent of the
Registrant arising out of his capacity as such.

                                       2
The Registrant has entered into Indemnification Agreements
with each of its officers and directors, pursuant to which the Registrant has
agreed to indemnify and advance expenses to such officers and directors to the
fullest extent permitted by applicable law.

                  The Registrant has obtained an insurance policy providing
coverage for certain liabilities of its officers and directors.

ITEM 7.           EXEMPTION FROM REGISTRATION CLAIMED.

          Not applicable.

ITEM 8.           EXHIBITS.

                  The following documents are filed as Exhibits hereto:
EXHIBIT
  NUMBER             DESCRIPTION
  -------            -----------
3.1                Certificate of Incorporation of the Company, as amended         Incorporated by reference
                                                                                     from Exhibit 3.1 to the
                                                                                     Company's Form S-1
                                                                                     Registration Statement No.
                                                                                     333-13627 dated November 19,
                                                                                     1997
  5.1                Opinion and Consent of Dewey Ballantine LLP with respect to     Filed herewith
                     the legality of the securities being registered
  10.1               1998 Employee Stock Purchase Plan                               Filed herewith
  10.2               1998 Non-Qualified Employee Stock Purchase Plan                 Filed herewith
  23.1               Consent of Dewey Ballantine LLP (contained in their opinion     Filed herewith
                     filed herewith as Exhibit 5.1)
  23.2               Consent of PricewaterhouseCoopers LLP                           Filed herewith
  24.1               Power of Attorney of directors and certain officers of the      Filed herewith
                     Company (included in Signature Page)
ITEM 9.   UNDERTAKINGS.

a)  The undersigned registrant hereby undertakes:

    (1) To file, during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:

        (i) To include any prospectus required by section 10(a)(3) of
the Securities Act of 1933;

                                       3
(ii) To reflect in the prospectus any facts or events arising after the
effective date of the registration statement (or the most recent post-effective
amendment thereof) which, individually or in the aggregate, represent a
fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that
which was registered) and any deviation from the low or high end of the
estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
changes in volume and price represent no more than a 20 percent change in the
maximum aggregate offering price set forth in the "Calculation of Registration
Fee" table in the effective registration statement;

        (iii) To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement;

provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
registration statement is on Form S-3, Form S-8 of Form F-3, and the information
required to be included in a post-effective amendment by those paragraphs is
contained in periodic reports filed with or furnished to the Commission by the
registrant pursuant to Section 13 or 15(d) of the Securities Exchange Act of
1934 that are incorporated by reference in the registration statement.

        (2) That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

        (3) To remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the termination of
the offering.

b) The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 that is incorporated by reference in the
Registration Statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

c) Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Act and is,
therefore, unenforceable. In the event that a claim for indemnification against
such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

                                       4
SIGNATURES

        The Registrant. Pursuant to the requirements of the Securities Act of
1933, the Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Tarrytown, State of New York, on September 30,
2004.

                        PROGENICS PHARMACEUTICALS, INC.

                        By:  /s/ PAUL J. MADDON, M.D., PH.D.
                             -------------------------------
                             Paul J. Maddon, M.D., Ph.D.
                             Chairman of the Board and Chief Executive Officer

                                POWER OF ATTORNEY

                  KNOW ALL PERSONS BY THESE PRESENTS, that each of the persons
whose names appear below constitute and appoint Paul J. Maddon, M.D., Ph.D.,
Ronald J. Prentki and Robert A. McKinney, and each of them, as his true and
lawful attorney-in-fact and agent, with full power of substitution and
resubstitution, for him and in his name, place and stead, in any and all
capacities, to execute any and all amendments to this Registration Statement,
and to file the same, together with all exhibits thereto, and other documents in
connection therewith, with the Securities and Exchange Commission, and such
other agencies, offices and persons as may be required by applicable law,
granting unto said attorney-in-fact and agent, full power and authority to do
and perform each and every act and thing requisite or necessary to be done in
and about the premises, as fully to all intents and purposes as he or she might
or could do in person, hereby ratifying and confirming all that each said
attorney-in-fact and agent may lawfully do or cause to be done by virtue hereof.

                  Pursuant to the requirements of the Securities Act of 1933,
this Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
Signature                                Capacity                                           Date
        ---------                                --------                                           ----
/s/ PAUL J. MADDON, M.D., PH.D.                  Chairman of the Board and Chief Executive          September 30, 2004
-------------------------------                  Officer (Principal Executive Officer)
Paul J. Maddon, M.D., Ph.D.

/s/ ROBERT A. MCKINNEY                           Vice President, Finance & Operations and           September 30, 2004
-----------------------                          Treasurer (Principal Financial and
Robert A. McKinney                               Accounting Officer)

/s/ CHARLES A. BAKER                             Director                                           September 30, 2004
--------------------
Charles A. Baker

/s/ KURT W. BRINER                               Director                                           September 30, 2004
------------------
Kurt W. Briner

/s/ MARK F. DALTON                               Director                                           September 30, 2004
------------------
Mark F. Dalton

/s/ STEPHEN P. GOFF, PH.D.                       Director                                           September 29, 2004
--------------------------
Stephen P. Goff, Ph.D.

/s/ PAUL F. JACOBSON                             Director                                           September 30, 2004
--------------------
Paul F. Jacobson

/s/ RONALD J. PRENTKI                            President and Director                             September 30, 2004
---------------------
Ronald J. Prentki

/s/ DAVID A. SCHEINBERG, M.D., PH.D.             Director                                           September 30, 2004
------------------------------------
David A. Scheinberg, M.D., Ph.D.
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