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    <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on March 1, 2022</div>
    <div>&#160;</div>
    <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
    <div>&#160;</div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">WASHINGTON, D.C. 20549</div>
    <div style="text-align: center; font-weight: bold;"><font style="font-size: 12pt;"> </font><br>
    </div>
    <div style="text-align: center; font-weight: bold;">
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    <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;"> <br>
    </div>
    <div>
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; font-size: 24pt; font-weight: bold;">Quantum-Si Incorporated</div>
    <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
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        <tr>
          <td style="width: 32.51%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Delaware</div>
          </td>
          <td style="width: 34%; vertical-align: top;">&#160;</td>
          <td style="width: 33%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">85-1388175</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32.51%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">(State or other jurisdiction of incorporation or organization)</div>
          </td>
          <td style="width: 34%; vertical-align: top;">&#160;</td>
          <td style="width: 33%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">(I.R.S. Employer</div>
            <div style="text-align: center; font-weight: bold;">Identification No.)</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 32.51%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 34%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 32.51%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">530 Old Whitfield Street</div>
            <div style="text-align: center; font-weight: bold;">Guilford, Connecticut 06437</div>
            <div style="text-align: center; font-weight: bold;">(Address of Principal Executive Offices)</div>
          </td>
          <td style="width: 34%; vertical-align: top;">&#160;</td>
          <td style="width: 33%; vertical-align: top;">
            <div>&#160;</div>
            <div style="text-align: center; font-weight: bold;">06437</div>
            <div style="text-align: center; font-weight: bold;">(Zip Code)</div>
          </td>
        </tr>

    </table>
    <div style="text-align: center; font-weight: bold;">2021 Equity Incentive Plan</div>
    <div style="text-align: center; font-weight: bold;">(Full title of the plan)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Jonathan M. Rothberg, Ph.D.</div>
    <div style="text-align: center; font-weight: bold;">Interim Chief Executive Officer</div>
    <div style="text-align: center; font-weight: bold;">Quantum-Si Incorporated</div>
    <div style="text-align: center; font-weight: bold;">530 Old Whitfield Street</div>
    <div style="text-align: center; font-weight: bold;">Guilford, Connecticut 06437</div>
    <div style="text-align: center; font-weight: bold;">(Name and address of agent for service)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">(203) 458-7100</div>
    <div style="text-align: center; font-weight: bold;">(Telephone number, including area code, of agent for service)</div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div>
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    <div style="text-align: justify; color: rgb(0, 0, 0); text-indent: 18pt;">
      <div><br>
      </div>
      <div>
        <div style="text-indent: 18pt; color: #000000; font-family: 'Times New Roman', Times, serif;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or
          an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
        <div>&#160;</div>
      </div>
    </div>
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        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Large accelerated filer &#9746;</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Accelerated filer &#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Non-accelerated filer&#160;&#160; &#9744;</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Smaller reporting company &#9746;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Emerging growth company &#9744;</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 18pt; color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
      accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
    <div>&#160;</div>
    <div>
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    <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
    <div>&#160;</div>
    <div style="text-align: justify;">This registration statement registers an aggregate of 5,516,659 additional shares of Class A common stock, par value $0.0001 per share, of Quantum-Si Incorporated (the &#8220;Registrant&#8221;) reserved under the Quantum-Si
      Incorporated 2021 Equity Incentive Plan (the &#8220;2021 Plan&#8221;), representing an increase of 5,516,659 shares reserved under the 2021 Plan effective January 1, 2022 by operation of the 2021 Plan&#8217;s &#8220;evergreen&#8221; provision. This registration statement
      registers additional securities of the same class as other securities for which a registration statement filed on Form S-8 (File No. 333-259271) relating to an employee benefit plan is effective. The information contained in the Registrant&#8217;s
      registration statement on Form S-8 filed with the Securities and Exchange Commission on September 2, 2021 (File No. 333-259271) is hereby incorporated by reference pursuant to General Instruction E of Form S-8.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">PART II</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div>&#160;</div>
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          <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 8.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Exhibits.</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zdd470e4b41c044359acb4c1cde8fc925">

        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-weight: bold;">Exhibit</div>
            <div style="font-weight: bold;">Number</div>
          </td>
          <td nowrap="nowrap" style="width: 49%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center; font-weight: bold;"><u>Exhibit Description</u></div>
          </td>
          <td nowrap="nowrap" style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-weight: bold;">Filed</div>
            <div style="font-weight: bold;">Herewith</div>
          </td>
          <td nowrap="nowrap" style="width: 13.1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Incorporated</div>
            <div style="text-align: center; font-weight: bold;">by Reference</div>
            <div style="text-align: center; font-weight: bold;">herein from</div>
            <div style="text-align: center; font-weight: bold;">Form or</div>
            <div style="text-align: center; font-weight: bold;">Schedule</div>
          </td>
          <td nowrap="nowrap" style="width: 10.88%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Filing Date</div>
          </td>
          <td nowrap="nowrap" style="width: 12.99%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">SEC File/</div>
            <div style="text-align: center; font-weight: bold;">Reg. Number</div>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1816431/000110465921081560/tm2118908d1_ex3-1.htm">4.1</a></div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div>Second Amended and Restated Certificate of Incorporation of the Registrant.</div>
          </td>
          <td style="width: 8%; vertical-align: top;">&#160;</td>
          <td style="width: 13.1%; vertical-align: top;">
            <div style="text-align: center;">8-K</div>
            <div style="text-align: center;">(Exhibit 3.1)</div>
          </td>
          <td style="width: 10.88%; vertical-align: top;">
            <div style="text-align: center;">6/15/2021</div>
          </td>
          <td style="width: 12.99%; vertical-align: top;">
            <div style="text-align: center;">001-39486</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td style="width: 49%; vertical-align: middle;">&#160;</td>
          <td style="width: 8%; vertical-align: top;">&#160;</td>
          <td style="width: 13.1%; vertical-align: top;">&#160;</td>
          <td style="width: 10.88%; vertical-align: top;">&#160;</td>
          <td style="width: 12.99%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1816431/000114036122007334/brhc10034564_ex3-2.htm">4.2</a></div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div>Amended and Restated Bylaws of the Registrant.</div>
          </td>
          <td style="width: 8%; vertical-align: top;">&#160;</td>
          <td style="width: 13.1%; vertical-align: top;">
            <div style="text-align: center;">10-K</div>
            <div style="text-align: center;">(Exhibit 3.2)</div>
          </td>
          <td style="width: 10.88%; vertical-align: top;">
            <div style="text-align: center;">3/1/2022</div>
          </td>
          <td style="width: 12.99%; vertical-align: top;">
            <div style="text-align: center;">001-39486</div>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1816431/000110465921064151/tm217673d12_ex4-1.htm">4.3</a></div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div>Specimen Class A Common Stock Certificate.</div>
          </td>
          <td style="width: 8%; vertical-align: top;">&#160;</td>
          <td style="width: 13.1%; vertical-align: top;">
            <div style="text-align: center;">S-4/A</div>
            <div style="text-align: center;">(Exhibit 4.1)</div>
          </td>
          <td style="width: 10.88%; vertical-align: top;">
            <div style="text-align: center;">5/11/2021</div>
          </td>
          <td style="width: 12.99%; vertical-align: top;">
            <div style="text-align: center;">333-253691</div>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" rowspan="1" style="width: 6%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 49%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 8%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 13.1%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 10.88%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 12.99%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1816431/000110465920103448/tm2030387d1_ex4-1.htm">4.4</a></div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div>Warrant Agreement, dated as of September 3, 2020, by and between Quantum-Si Incorporated (formerly HighCape Capital Acquisition Corp.) and Continental Stock Transfer &amp; Trust Company.</div>
          </td>
          <td style="width: 8%; vertical-align: top;">&#160;</td>
          <td style="width: 13.1%; vertical-align: top;">
            <div style="text-align: center;">8-K</div>
            <div style="text-align: center;">(Exhibit 4.1)</div>
          </td>
          <td style="width: 10.88%; vertical-align: top;">
            <div style="text-align: center;">9/9/2020</div>
          </td>
          <td style="width: 12.99%; vertical-align: top;">
            <div style="text-align: center;">001-39486</div>
          </td>
        </tr>
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          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td style="width: 49%; vertical-align: middle;">&#160;</td>
          <td style="width: 8%; vertical-align: middle;">&#160;</td>
          <td style="width: 13.1%; vertical-align: middle;">&#160;</td>
          <td style="width: 10.88%; vertical-align: middle;">&#160;</td>
          <td style="width: 12.99%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="brhc10034392_ex5-1.htm">5.1</a></div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div>Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.</div>
          </td>
          <td style="width: 8%; vertical-align: top;">
            <div style="text-align: center;">X</div>
          </td>
          <td style="width: 13.1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 10.88%; vertical-align: middle;">&#160;</td>
          <td style="width: 12.99%; vertical-align: middle;">&#160;</td>
        </tr>
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          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td style="width: 49%; vertical-align: middle;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13.1%; vertical-align: middle;">&#160;</td>
          <td style="width: 10.88%; vertical-align: middle;">&#160;</td>
          <td style="width: 12.99%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="brhc10034392_ex5-1.htm">23.1</a></div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div>Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of counsel filed as Exhibit 5.1).</div>
          </td>
          <td style="width: 8%; vertical-align: top;">
            <div style="text-align: center;">X</div>
          </td>
          <td style="width: 13.1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 10.88%; vertical-align: middle;">&#160;</td>
          <td style="width: 12.99%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td style="width: 49%; vertical-align: middle;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13.1%; vertical-align: middle;">&#160;</td>
          <td style="width: 10.88%; vertical-align: middle;">&#160;</td>
          <td style="width: 12.99%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="brhc10034392_ex23-2.htm">23.2</a></div>
          </td>
          <td nowrap="nowrap" style="width: 49%; vertical-align: top;">
            <div>Consent of Deloitte &amp; Touche LLP, independent registered public accounting firm.</div>
          </td>
          <td style="width: 8%; vertical-align: top;">
            <div style="text-align: center;">X</div>
          </td>
          <td style="width: 13.1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 10.88%; vertical-align: middle;">&#160;</td>
          <td style="width: 12.99%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td style="width: 49%; vertical-align: middle;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13.1%; vertical-align: middle;">&#160;</td>
          <td style="width: 10.88%; vertical-align: middle;">&#160;</td>
          <td style="width: 12.99%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="#SIGNATURES">24.1</a></div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div>Power of Attorney (included on the signature page hereof).</div>
          </td>
          <td style="width: 8%; vertical-align: top;">
            <div style="text-align: center;">X</div>
          </td>
          <td style="width: 13.1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 10.88%; vertical-align: middle;">&#160;</td>
          <td style="width: 12.99%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" rowspan="1" style="width: 6%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 49%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 8%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 13.1%; vertical-align: bottom;">&#160;</td>
          <td rowspan="1" style="width: 10.88%; vertical-align: middle;">&#160;</td>
          <td rowspan="1" style="width: 12.99%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1816431/000110465921081560/tm2118908d1_ex10-13d1.htm">99.1+</a></div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div>Quantum-Si Incorporated 2021 Equity Incentive Plan.</div>
          </td>
          <td style="width: 8%; vertical-align: bottom;">&#160;</td>
          <td style="width: 13.1%; vertical-align: bottom;">
            <div style="text-align: center;">8-K</div>
            <div style="text-align: center;">(Exhibit 10.13.1)</div>
          </td>
          <td style="width: 10.88%; vertical-align: middle;">
            <div style="text-align: center;">6/15/2021</div>
          </td>
          <td style="width: 12.99%; vertical-align: middle;">
            <div style="text-align: center;">001-39486</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td style="width: 49%; vertical-align: middle;">&#160;</td>
          <td style="width: 8%; vertical-align: middle;">&#160;</td>
          <td style="width: 13.1%; vertical-align: middle;">&#160;</td>
          <td style="width: 10.88%; vertical-align: middle;">&#160;</td>
          <td style="width: 12.99%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1816431/000110465921081560/tm2118908d1_ex10-13d2.htm">99.2+</a></div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div>Form of Stock Option Agreement under 2021 Equity Incentive Plan.</div>
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            <div style="text-align: center;">001-39486</div>
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          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
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          <td style="width: 49%; vertical-align: top;">
            <div>Form of Restricted Stock Unit Agreement under 2021 Equity Incentive Plan.</div>
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            <div style="text-align: center;">9/2/2021</div>
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          <td style="width: 12.99%; vertical-align: middle;">
            <div style="text-align: center;">333-259271</div>
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        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">
            <div><a href="brhc10034392_ex107.htm">107</a></div>
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          <td style="width: 49%; vertical-align: top;">
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          <td style="width: 8%; vertical-align: bottom;">
            <div style="text-align: center;">X</div>
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          <td style="width: 13.1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 10.88%; vertical-align: middle;">&#160;</td>
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    <div style="color: rgb(0, 0, 0);">+ Denotes management contract or compensatory plan or arrangement</div>
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    <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
      and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Guilford, State of Connecticut, on March 1, 2022.</div>
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          <td rowspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
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            <div>/s/ Jonathan M. Rothberg, Ph.D.</div>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 3%; vertical-align: top;">&#160;</td>
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            <div>Jonathan M. Rothberg, Ph.D.</div>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
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          <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Date</div>
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          <td rowspan="1" style="width: 38%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 38%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 20%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 38%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">/s/ Jonathan M. Rothberg, Ph.D.</div>
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          <td rowspan="2" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="2" style="width: 38%; vertical-align: middle;">
            <div style="text-align: center;">Interim Chief Executive Officer and Executive Chairman</div>
            <div style="text-align: center;">(Principal Executive Officer)</div>
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          <td rowspan="2" style="width: 2%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 20%; vertical-align: middle;">
            <div style="text-align: center;">
              <div>March 1, 2022</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top;">
            <div style="text-align: center;">Jonathan M. Rothberg, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 38%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 20%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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          <td rowspan="2" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="2" style="width: 38%; vertical-align: middle;">
            <div style="text-align: center;">Chief Financial Officer (Principal Financial and Accounting Officer)</div>
          </td>
          <td rowspan="2" style="width: 2%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 20%; vertical-align: middle; text-align: center;">
            <div>March 1, 2022</div>
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        <tr>
          <td style="width: 38%; vertical-align: top;">
            <div style="text-align: center;">Claudia Drayton</div>
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        <tr>
          <td style="width: 38%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 38%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 20%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">/s/ Marijn Dekkers, Ph.D.</div>
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          <td rowspan="2" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="2" style="width: 38%; vertical-align: middle;">
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          <td rowspan="2" style="width: 2%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 20%; vertical-align: middle; text-align: center;">
            <div>March 1, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top;">
            <div style="text-align: center;">Marijn Dekkers, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 38%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 20%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">/s/ Ruth Fattori</div>
          </td>
          <td rowspan="2" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="2" style="width: 38%; vertical-align: middle;">
            <div style="text-align: center;">Director</div>
          </td>
          <td rowspan="2" style="width: 2%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 20%; vertical-align: middle; text-align: center;">
            <div>March 1, 2022</div>
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        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top;">
            <div style="text-align: center;">Ruth Fattori</div>
          </td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 38%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 20%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">/s/ Brigid A. Makes</div>
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          <td rowspan="2" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="2" style="width: 38%; vertical-align: middle;">
            <div style="text-align: center;">Director</div>
          </td>
          <td rowspan="2" style="width: 2%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 20%; vertical-align: middle; text-align: center;">
            <div>March 1, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top;">
            <div style="text-align: center;">Brigid A. Makes</div>
          </td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 38%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 20%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">/s/ Michael Mina, M.D., Ph.D.</div>
          </td>
          <td rowspan="2" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="2" style="width: 38%; vertical-align: middle;">
            <div style="text-align: center;">Director</div>
          </td>
          <td rowspan="2" style="width: 2%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 20%; vertical-align: middle; text-align: center;">
            <div>March 1, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top;">
            <div style="text-align: center;">Michael Mina, M.D., Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 38%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 38%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 20%; vertical-align: middle;">&#160;</td>
        </tr>
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          <td style="width: 38%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">/s/ Kevin Rakin</div>
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          <td rowspan="2" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="2" style="width: 38%; vertical-align: middle;">
            <div style="text-align: center;">Director</div>
          </td>
          <td rowspan="2" style="width: 2%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 20%; vertical-align: middle; text-align: center;">
            <div>March 1, 2022</div>
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        <tr>
          <td style="width: 38%; vertical-align: top;">
            <div style="text-align: center;">Kevin Rakin</div>
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        <tr>
          <td style="width: 38%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 38%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
          <td style="width: 20%; vertical-align: middle;">&#160;</td>
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          <td style="width: 38%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">/s/ James Tananbaum, M.D.</div>
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          <td rowspan="2" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="2" style="width: 38%; vertical-align: middle;">
            <div style="text-align: center;">Director</div>
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          <td rowspan="2" style="width: 2%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 20%; vertical-align: middle; text-align: center;">
            <div>March 1, 2022</div>
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            <div style="text-align: center;">James Tananbaum, M.D.</div>
          </td>
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    <div><br>
    </div>
    <div><br>
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{"company-data": {"conformed-name": "Quantum-Si Inc", "cik": "0001816431", "assigned-sic": "3829", "irs-number": "851388175", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-263154", "film-number": "22698677"}, "business-address": {"street1": "530 OLD WHITFIELD STREET", "city": "GUILFORD", "state": "CT", "zip": "06437", "phone": "(203) 458-7100"}, "mail-address": {"street1": "530 OLD WHITFIELD STREET", "city": "GUILFORD", "state": "CT", "zip": "06437"}, "former-company": {"former-conformed-name": "HighCape Capital Acquisition Corp.", "date-changed": "20200629"}}
As filed with the Securities and Exchange Commission on March 1, 2022
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Quantum-Si Incorporated
(Exact name of registrant as specified in its charter)
Delaware
85-1388175
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer
Identification No.)
530 Old Whitfield Street
Guilford, Connecticut 06437
(Address of Principal Executive Offices)
06437
(Zip Code)
2021 Equity Incentive Plan
(Full title of the plan)
Jonathan M. Rothberg, Ph.D.
Interim Chief Executive Officer
Quantum-Si Incorporated
530 Old Whitfield Street
Guilford, Connecticut 06437
(Name and address of agent for service)
(203) 458-7100
(Telephone number, including area code, of agent for service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or
          an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☒
Accelerated filer ☐
Non-accelerated filer   ☐
Smaller reporting company ☒
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
      accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY NOTE
This registration statement registers an aggregate of 5,516,659 additional shares of Class A common stock, par value $0.0001 per share, of Quantum-Si Incorporated (the "Registrant") reserved under the Quantum-Si
      Incorporated 2021 Equity Incentive Plan (the "2021 Plan"), representing an increase of 5,516,659 shares reserved under the 2021 Plan effective January 1, 2022 by operation of the 2021 Plan's "evergreen" provision. This registration statement
      registers additional securities of the same class as other securities for which a registration statement filed on Form S-8 (File No. 333-259271) relating to an employee benefit plan is effective. The information contained in the Registrant's
      registration statement on Form S-8 filed with the Securities and Exchange Commission on September 2, 2021 (File No. 333-259271) is hereby incorporated by reference pursuant to General Instruction E of Form S-8.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 8.
Exhibits.
Exhibit
Number
Exhibit Description
Filed
Herewith
Incorporated
by Reference
herein from
Form or
Schedule
Filing Date
SEC File/
Reg. Number
4.1
Second Amended and Restated Certificate of Incorporation of the Registrant.
8-K
(Exhibit 3.1)
6/15/2021
001-39486
4.2
Amended and Restated Bylaws of the Registrant.
10-K
(Exhibit 3.2)
3/1/2022
001-39486
4.3
Specimen Class A Common Stock Certificate.
S-4/A
(Exhibit 4.1)
5/11/2021
333-253691
4.4
Warrant Agreement, dated as of September 3, 2020, by and between Quantum-Si Incorporated (formerly HighCape Capital Acquisition Corp.) and Continental Stock Transfer & Trust Company.
8-K
(Exhibit 4.1)
9/9/2020
001-39486
5.1
Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
X
23.1
Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in opinion of counsel filed as Exhibit 5.1).
X
23.2
Consent of Deloitte & Touche LLP, independent registered public accounting firm.
X
24.1
Power of Attorney (included on the signature page hereof).
X
99.1+
Quantum-Si Incorporated 2021 Equity Incentive Plan.
8-K
(Exhibit 10.13.1)
6/15/2021
001-39486
99.2+
Form of Stock Option Agreement under 2021 Equity Incentive Plan.
8-K
(Exhibit 10.13.2)
6/15/2021
001-39486
99.3+
Form of Restricted Stock Unit Agreement under 2021 Equity Incentive Plan.
S-8
(Exhibit 99.3)
9/2/2021
333-259271
107
Filing Fee Table
X
+ Denotes management contract or compensatory plan or arrangement
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
      and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Guilford, State of Connecticut, on March 1, 2022.
QUANTUM-SI INCORPORATED
By:
/s/ Jonathan M. Rothberg, Ph.D.
Jonathan M. Rothberg, Ph.D.
Interim Chief Executive Officer
POWER OF ATTORNEY
Each person whose signature appears below constitutes and appoints each of Jonathan M. Rothberg, Ph.D. and Claudia Drayton, acting alone or together with another attorney-in-fact, as his or her true
      and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for such person and in his or her name, place and stead, in any and all capacities, to sign any or all further amendments (including post-effective amendments)
      to this registration statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power
      and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said
      attorney-in-fact and agent, or his or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the date indicated.
Signature
Title
Date
/s/ Jonathan M. Rothberg, Ph.D.
Interim Chief Executive Officer and Executive Chairman
(Principal Executive Officer)
March 1, 2022
Jonathan M. Rothberg, Ph.D.
/s/ Claudia Drayton
Chief Financial Officer (Principal Financial and Accounting Officer)
March 1, 2022
Claudia Drayton
/s/ Marijn Dekkers, Ph.D.
Director
March 1, 2022
Marijn Dekkers, Ph.D.
/s/ Ruth Fattori
Director
March 1, 2022
Ruth Fattori
/s/ Brigid A. Makes
Director
March 1, 2022
Brigid A. Makes
/s/ Michael Mina, M.D., Ph.D.
Director
March 1, 2022
Michael Mina, M.D., Ph.D.
/s/ Kevin Rakin
Director
March 1, 2022
Kevin Rakin
/s/ James Tananbaum, M.D.
Director
March 1, 2022
James Tananbaum, M.D.