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    <div style="text-align: center; color: #000000; font-weight: bold;">As filed with the Securities and Exchange Commission on November 4, 2024</div>
    <div style="text-align: right; color: #000000; font-weight: bold;">Registration No. 333-</div>
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    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">UNDER</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-variant: small-caps; font-weight: bold;">Opus Genetics, Inc.</div>
    <div style="text-align: center; color: #000000;">(Exact name of registrant as specified in its charter)</div>
    <div><br>
    </div>
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          <td style="width: 49%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
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          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">11-3516358</div>
          </td>
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          <td nowrap="nowrap" style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(State or other jurisdiction of</div>
            <div style="text-align: center; color: rgb(0, 0, 0);">incorporation or organization)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: #000000;">(I.R.S. Employer</div>
            <div style="text-align: center; color: #000000;">Identification Number.)</div>
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          <td style="width: 49%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: #000000; font-weight: bold;">37000 Grand River Avenue, Suite 120</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Farmington Hills, MI</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 49%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">48335</div>
          </td>
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          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(Address of principal executive offices)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(Zip code)</div>
          </td>
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    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z4bc94e7e5d4440b3b04b5f96ff77e3ec">

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          <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Ocuphire Pharma, Inc. 2021 Inducement Plan</div>
          </td>
        </tr>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(Full title of the plan)</div>
          </td>
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          <td style="width: 100%; vertical-align: middle; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000; font-weight: bold;">Dr. George Magrath</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Chief Executive Officer</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Opus Genetics, Inc.</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">37000 Grand River Avenue, Suite 120</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Farmington Hills, MI 48335</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">(248) 957-9024</div>
          </td>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">(Name, address, and telephone number, including area code, of agent for service)</div>
          </td>
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    <div><br>
    </div>
    <div style="text-align: justify; color: #000000;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
      of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div><br>
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          <td style="width: 45%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Large accelerated filer &#9744;</div>
          </td>
          <td style="width: 55%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Accelerated filer &#9744;</div>
          </td>
        </tr>
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          <td style="width: 45%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Non-accelerated filer &#9746;</div>
          </td>
          <td style="width: 55%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Smaller reporting company &#9746;</div>
          </td>
        </tr>
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          <td style="width: 45%; vertical-align: top;">&#160;</td>
          <td style="width: 55%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Emerging growth company &#9744;</div>
          </td>
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    <div><br>
    </div>
    <div style="text-align: justify; color: #000000;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
      provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
    <div><br>
    </div>
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    <div style="text-align: center; color: #000000; font-weight: bold;">EXPLANATORY NOTE</div>
    <div><font style="color: #000000;"> </font><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED PURSUANT TO GENERAL INSTRUCTION E TO FORM S-8</div>
    <div><font style="color: #000000;"> </font><br>
    </div>
    <div style="text-indent: 36pt; color: #000000;">This Registration Statement on Form S-8 (this &#8220;Registration Statement&#8221;) is being filed by Opus Genetics, Inc. (the &#8220;Registrant&#8221;), relating to 300,000 shares of its common stock, par value $0.0001 per
      share (the &#8220;Common Stock&#8221;), to be issued pursuant to the Ocuphire Pharma, Inc. 2021 Inducement Plan, as amended (the &#8220;Plan&#8221;). This Registration Statement on Form S-8 hereby incorporates by reference the contents of the Registrant's prior Registration
      Statements on Form S-8 filed with the Securities and Exchange Commission (the &#8220;Commission&#8221;) on <a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036121011064/nt10022400x1_s8.htm">March 31, 2021</a> (Registration No. 333-254923) and <a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036123054063/ef20014941_s8.htm">November 21, 2023</a> (Registration No. 333-275673) relating to shares of Common Stock issuable under the Plan (the &#8220;Prior Registration Statements&#8221;). The
      Prior Registration Statements are currently effective. This Registration Statement relates to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with General Instruction E of Form
      S-8 regarding Registration of Additional Securities. Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements are incorporated herein by reference and made part of this Registration Statement, except as amended
      hereby.</div>
    <div><font style="color: #000000;"> </font><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">PART I</div>
    <div><font style="color: #000000;"> </font><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; color: #000000;">All information required by Part I to be contained in the prospectus is omitted from this Registration Statement in accordance with the explanatory note to Part I of Form S-8 and Rule 428 under the
      Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;). Documents containing the information required by Part I of the Registration Statement will be sent or given to Plan participants as specified by Rule 428(b)(1) under the Securities Act.</div>
    <div><font style="color: #000000;"> </font><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">PART II</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div><font style="color: #000000;"> </font><br>
    </div>
    <div>
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            <td style="text-align: right; vertical-align: top; width: 36pt;">
              <div style="text-align: left;"><font style="font-weight: bold; color: #000000;">Item 3.</font></div>
            </td>
            <td style="text-align: left; vertical-align: top; width: auto;">
              <div><font style="font-weight: bold; color: rgb(0, 0, 0);">Incorporation of Documents By Reference.</font></div>
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    </div>
    <div><font style="color: #000000;"> </font><br>
    </div>
    <div style="text-indent: 36pt; color: #000000;">The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"></sup>:</div>
    <div><font style="color: #000000;"> </font><br>
    </div>
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              <div style="text-align: left;">(a)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div>the Registrant&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed with the Commission on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1228627/000114036124012399/ef20015277_10k.htm">March 8, 2024</a>;</div>
            </td>
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    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z91f51772eb4f4aa5a29afcf541e3dc10">

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            <td style="width: 18pt; vertical-align: top; text-align: right;">
              <div style="text-align: left;">(b)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div>the Registrant&#8217;s Quarterly Reports on Form 10-Q, filed with the Commission on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1228627/000114036124025481/ef20026287_10q.htm">May 10, 2024</a> and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1228627/000114036124037068/ef20030049_10q.htm">August 13, 2024</a>;</div>
            </td>
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    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zcae1d41b441f4e9fb7c723ec8c967ae1">

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            <td style="width: 18pt; vertical-align: top; text-align: right;">
              <div style="text-align: left;">(c)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div>the Registrant&#8217;s Current Reports on Form 8-K, filed with the Commission on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1228627/000114036124008352/ef20021883_8k.htm">February 16, 2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1228627/000114036124020320/ef20027138_8k.htm">April 17, 2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1228627/000114036124030012/ef20031101_8k.htm">June 13, 2024</a>,
                and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1228627/000114036124043915/ef20037500_8k.htm">October 22, 2024</a>; and</div>
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    <div><br>
    </div>
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            <td style="width: 18pt; vertical-align: top; text-align: right;">
              <div style="text-align: left;">(d)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div>the description of the Registrant&#8217;s Common Stock contained in the Registrant&#8217;s Form 8-A (File No. 001-34079), as filed with the Commission pursuant to Sections 12(b) and 12(g) of the Securities Exchange Act of 1934, as amended (the
                &#8220;Exchange Act&#8221;), on <a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036119010684/form8a12b.htm">June 7, 2019</a>, including any amendments or reports filed for the purpose of updating such description, including <a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036121008099/brhc10021462_ex4-11.htm">Exhibit 4.11</a> to the Registrant&#8217;s Annual Report on Form 10-K, filed with the Commission on March 11, 2021.</div>
            </td>
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    </div>
    <div><font style="color: #000000;"> </font><br>
    </div>
    <div style="text-indent: 36pt; color: #000000;">All documents subsequently filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, after the date of this Registration Statement and prior to the
      filing of a post-effective amendment to this Registration Statement which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein
      and to be a part hereof from the respective dates of filing of such documents (such documents, and the documents enumerated above, being hereinafter referred to as &#8220;Incorporated Documents&#8221;).</div>
    <br>
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    </div>
    <div style="text-indent: 36pt; color: #000000;">Any statement contained in an Incorporated Document shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other
      subsequently filed Incorporated Document modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; color: #000000;">Notwithstanding the foregoing, unless specifically stated to the contrary, none of the information disclosed by the Registrant under Items 2.02 or 7.01 of any current report on Form 8-K, including the
      related exhibits under Item 9.01, that the Registrant may from time to time furnish to the Commission will be incorporated by reference into, or otherwise included in, this Registration Statement.</div>
    <div><br>
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          <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 8.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibits.</div>
          </td>
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    <div><font style="color: #000000;"> </font><br>
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          <td style="width: 7%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: #000000; font-weight: bold;">Exhibit</div>
            <div style="color: #000000; font-weight: bold;">Number</div>
          </td>
          <td style="width: 1%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td style="width: 92%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Description</div>
          </td>
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          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036124037068/ef20030049_ex3-1.htm">4.1</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Quarterly Report on Form 10-Q, filed with the Commission on August 13, 2024).</div>
          </td>
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        <tr>
          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 92%; vertical-align: top;">&#160;</td>
        </tr>
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          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036124043915/ef20037500_ex3-2.htm">4.2</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant&#8217;s Current Report on Form 8-K, filed with the Commission on
              October 22, 2024).</div>
          </td>
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        <tr>
          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 92%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036124043915/ef20037500_ex3-3.htm">4.3</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Registrant&#8217;s Current Report on Form 8-K, filed with the Commission on October 22, 2024).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 92%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036121008099/brhc10021462_ex10-41.htm">4.4</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Ocuphire Pharma, Inc. 2021 Inducement Plan (incorporated by reference to Exhibit 10.41 to the Registrant&#8217;s Annual Report on Form 10-K, filed with the Commission on March 11, 2021).</div>
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          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 92%; vertical-align: top;">&#160;</td>
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          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1228627/000114036123050844/ef20013742_ex10-3.htm">4.5</a></div>
          </td>
          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">First Amendment to Ocuphire Pharma, Inc. 2021 Inducement Plan (incorporated by reference to Exhibit 10.3 to the Registrant&#8217;s Current Report on Form 8-K, filed with the Commission on November 1, 2023).</div>
          </td>
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          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 92%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="ef20037930_ex4-6.htm">4.6*</a></div>
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          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Second Amendment to Ocuphire Pharma, Inc. 2021 Inducement Plan.</div>
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          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 92%; vertical-align: top;">&#160;</td>
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          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="ef20037930_ex5-1.htm">5.1*</a></div>
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          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Opinion of Sidley Austin LLP.</div>
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          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 92%; vertical-align: top;">&#160;</td>
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          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="ef20037930_ex23-1.htm">23.1*</a></div>
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          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Consent of Ernst &amp; Young LLP.</div>
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          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 92%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="ef20037930_ex5-1.htm">23.2*</a></div>
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          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Consent of Sidley Austin LLP (included in Exhibit 5.1).</div>
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          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 92%; vertical-align: top;">&#160;</td>
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          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="#POWEROFATTORNEY">24.1*</a></div>
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          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Power of Attorney (included after the signature of the Registrant contained on Signature Page of this Registration Statement).</div>
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          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 92%; vertical-align: top;">&#160;</td>
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          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="ef20037930_ex107.htm">107*</a></div>
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          <td style="width: 1%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 92%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">Filing Fee Table.</div>
          </td>
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    <div><br>
    </div>
    <div style="color: #000000;">* Filed herewith.</div>
    <div style="color: #000000;"> <br>
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    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
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    <div><font style="color: #000000;"> </font><br>
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    <div style="text-indent: 36pt; color: #000000;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly
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            <div style="color: rgb(0, 0, 0); font-weight: bold;">OPUS GENETICS, INC.</div>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
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          <td rowspan="1" colspan="2" style="vertical-align: top;">&#160;</td>
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            <div style="color: #000000;">By:</div>
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            <div style="color: rgb(0, 0, 0);">/s/ Dr. George Magrath</div>
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          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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            <div style="color: rgb(0, 0, 0);">Name:</div>
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          <td style="width: 45.09%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Dr. George Magrath</div>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
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            <div style="color: rgb(0, 0, 0);">Title:</div>
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            <div style="color: rgb(0, 0, 0);">Chief Executive Officer</div>
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          <td style="width: 50%; vertical-align: top;">&#160;</td>
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    <div style="text-align: center; color: #000000; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
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    <div style="text-indent: 36pt; color: #000000;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Dr. George Magrath,<font style="font-weight: bold;">&#160;</font>Nirav Jhaveri and Amy Rabourn
      as his or her true and lawful attorneys-in-fact and agents with full power of substitution, severally, for him in any and all capacities, to sign the Registration Statement on Form S-8 of Opus Genetics, Inc., and any or all amendments (including
      post-effective amendments thereto), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to
      do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and
      agents, or his or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</div>
    <div><font style="color: #000000;"> </font><br>
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    <div style="text-indent: 36pt; color: #000000;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.</div>
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          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">&#160;<font style="font-weight: bold;">SIGNATURE</font></div>
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          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">TITLE</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">DATE</div>
          </td>
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          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
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          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Dr. George Magrath</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Dr. George Magrath</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">
            <div style="text-align: center; color: #000000;">Chief Executive Officer &amp; Director</div>
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          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">November 4, 2024</div>
          </td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Nirav Jhaveri</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Nirav Jhaveri</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">
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            <div style="text-align: center; color: #000000;">(Principal Financial Officer)</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">November 4, 2024</div>
          </td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Amy Rabourn</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">
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          </td>
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          <td style="width: 48%; vertical-align: top;">
            <div style="text-align: center; color: #000000;">Senior Vice President of Finance</div>
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          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">November 4, 2024</div>
          </td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Cam Gallagher</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Cam Gallagher</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Chair of the Board</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">November 4, 2024</div>
          </td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Sean Ainsworth</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Sean Ainsworth</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">November 4, 2024</div>
          </td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Dr. Jean Bennett</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">
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          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">November 4, 2024</div>
          </td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Susan K. Benton</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">
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          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">November 4, 2024</div>
          </td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 48%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 25%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>

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        <tr>
          <td style="width: 25%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ Dr. Adrienne Graves</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Dr. Adrienne Graves</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0);">November 4, 2024</div>
          </td>
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[{"type": "S-8", "sequence": "1", "filename": "ef20037930_s8.htm", "description": "S-8", "secsgml_size_bytes": 53531}]
{"company-data": {"conformed-name": "Opus Genetics, Inc.", "cik": "0001228627", "assigned-sic": "2834", "organization-name": "03 Life Sciences", "irs-number": "113516358", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-282988", "film-number": "241424601"}, "business-address": {"street1": "37000 GRAND RIVER AVE.", "street2": "SUITE 120", "city": "FARMINGTON HILLS", "state": "MI", "zip": "48335", "phone": "248-681-9815"}, "mail-address": {"street1": "37000 GRAND RIVER AVE.", "street2": "SUITE 120", "city": "FARMINGTON HILLS", "state": "MI", "zip": "48335"}, "former-company": [{"former-conformed-name": "Ocuphire Pharma, Inc.", "date-changed": "20201109"}, {"former-conformed-name": "REXAHN PHARMACEUTICALS, INC.", "date-changed": "20050516"}, {"former-conformed-name": "CORPORATE ROAD SHOW DOT COM INC", "date-changed": "20030423"}]}
As filed with the Securities and Exchange Commission on November 4, 2024
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Opus Genetics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
11-3516358
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification Number.)
37000 Grand River Avenue, Suite 120
Farmington Hills, MI
48335
(Address of principal executive offices)
(Zip code)
Ocuphire Pharma, Inc. 2021 Inducement Plan
(Full title of the plan)
Dr. George Magrath
Chief Executive Officer
Opus Genetics, Inc.
37000 Grand River Avenue, Suite 120
Farmington Hills, MI 48335
(248) 957-9024
(Name, address, and telephone number, including area code, of agent for service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
      of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☐
Accelerated filer ☐
Non-accelerated filer ☒
Smaller reporting company ☒
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
      provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY NOTE
INFORMATION REQUIRED PURSUANT TO GENERAL INSTRUCTION E TO FORM S-8
This Registration Statement on Form S-8 (this "Registration Statement") is being filed by Opus Genetics, Inc. (the "Registrant"), relating to 300,000 shares of its common stock, par value $0.0001 per
      share (the "Common Stock"), to be issued pursuant to the Ocuphire Pharma, Inc. 2021 Inducement Plan, as amended (the "Plan"). This Registration Statement on Form S-8 hereby incorporates by reference the contents of the Registrant's prior Registration
      Statements on Form S-8 filed with the Securities and Exchange Commission (the "Commission") on
March 31, 2021
(Registration No. 333-254923) and
November 21, 2023
(Registration No. 333-275673) relating to shares of Common Stock issuable under the Plan (the "Prior Registration Statements"). The
      Prior Registration Statements are currently effective. This Registration Statement relates to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with General Instruction E of Form
      S-8 regarding Registration of Additional Securities. Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements are incorporated herein by reference and made part of this Registration Statement, except as amended
      hereby.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
All information required by Part I to be contained in the prospectus is omitted from this Registration Statement in accordance with the explanatory note to Part I of Form S-8 and Rule 428 under the
      Securities Act of 1933, as amended (the "Securities Act"). Documents containing the information required by Part I of the Registration Statement will be sent or given to Plan participants as specified by Rule 428(b)(1) under the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents By Reference.
The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement
:
(a)
the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed with the Commission on
March 8, 2024
;
(b)
the Registrant's Quarterly Reports on Form 10-Q, filed with the Commission on
May 10, 2024
and
August 13, 2024
;
(c)
the Registrant's Current Reports on Form 8-K, filed with the Commission on
February 16, 2024
,
April 17, 2024
,
June 13, 2024
,
                and
October 22, 2024
; and
(d)
the description of the Registrant's Common Stock contained in the Registrant's Form 8-A (File No. 001-34079), as filed with the Commission pursuant to Sections 12(b) and 12(g) of the Securities Exchange Act of 1934, as amended (the
                "Exchange Act"), on
June 7, 2019
, including any amendments or reports filed for the purpose of updating such description, including
Exhibit 4.11
to the Registrant's Annual Report on Form 10-K, filed with the Commission on March 11, 2021.
All documents subsequently filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, after the date of this Registration Statement and prior to the
      filing of a post-effective amendment to this Registration Statement which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein
      and to be a part hereof from the respective dates of filing of such documents (such documents, and the documents enumerated above, being hereinafter referred to as "Incorporated Documents").
Any statement contained in an Incorporated Document shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other
      subsequently filed Incorporated Document modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Notwithstanding the foregoing, unless specifically stated to the contrary, none of the information disclosed by the Registrant under Items 2.02 or 7.01 of any current report on Form 8-K, including the
      related exhibits under Item 9.01, that the Registrant may from time to time furnish to the Commission will be incorporated by reference into, or otherwise included in, this Registration Statement.
Item 8.
Exhibits.
Exhibit
Number
Description
4.1
Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q, filed with the Commission on August 13, 2024).
4.2
Certificate of Amendment to the Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K, filed with the Commission on
              October 22, 2024).
4.3
Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.3 to the Registrant's Current Report on Form 8-K, filed with the Commission on October 22, 2024).
4.4
Ocuphire Pharma, Inc. 2021 Inducement Plan (incorporated by reference to Exhibit 10.41 to the Registrant's Annual Report on Form 10-K, filed with the Commission on March 11, 2021).
4.5
First Amendment to Ocuphire Pharma, Inc. 2021 Inducement Plan (incorporated by reference to Exhibit 10.3 to the Registrant's Current Report on Form 8-K, filed with the Commission on November 1, 2023).
4.6*
Second Amendment to Ocuphire Pharma, Inc. 2021 Inducement Plan.
5.1*
Opinion of Sidley Austin LLP.
23.1*
Consent of Ernst & Young LLP.
23.2*
Consent of Sidley Austin LLP (included in Exhibit 5.1).
24.1*
Power of Attorney (included after the signature of the Registrant contained on Signature Page of this Registration Statement).
107*
Filing Fee Table.
* Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly
      caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Farmington Hills, State of Michigan, on November 4, 2024.
OPUS GENETICS, INC.
By:
/s/ Dr. George Magrath
Name:
Dr. George Magrath
Title:
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Dr. George Magrath,
Nirav Jhaveri and Amy Rabourn
      as his or her true and lawful attorneys-in-fact and agents with full power of substitution, severally, for him in any and all capacities, to sign the Registration Statement on Form S-8 of Opus Genetics, Inc., and any or all amendments (including
      post-effective amendments thereto), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to
      do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and
      agents, or his or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.
SIGNATURE
TITLE
DATE
/s/ Dr. George Magrath
Dr. George Magrath
Chief Executive Officer & Director
(Principal Executive Officer)
November 4, 2024
/s/ Nirav Jhaveri
Nirav Jhaveri
Chief Financial Officer
(Principal Financial Officer)
November 4, 2024
/s/ Amy Rabourn
Amy Rabourn
Senior Vice President of Finance
(Principal Accounting Officer)
November 4, 2024
/s/ Cam Gallagher
Cam Gallagher
Chair of the Board
November 4, 2024
/s/ Sean Ainsworth
Sean Ainsworth
Director
November 4, 2024
/s/ Dr. Jean Bennett
Dr. Jean Bennett
Director
November 4, 2024
/s/ Susan K. Benton
Susan K. Benton
Director
November 4, 2024
/s/ Dr. Adrienne Graves
Dr. Adrienne Graves
Director
November 4, 2024
/s/ James S. Manuso
James S. Manuso
Director
November 4, 2024
/s/ Richard J. Rodgers
Richard J. Rodgers
Director
November 4, 2024
/s/ Dr. Benjamin R. Yerxa
Dr. Benjamin R. Yerxa
President and Director
November 4, 2024