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    <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on April 6, 2023</div>
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      <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
      <div style="text-align: right; font-weight: bold;"> <br>
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    <div style="text-align: center; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
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    <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
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      <div><br>
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    <div style="text-align: center; font-size: 24pt; font-weight: bold;">Immunocore Holdings plc</div>
    <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;">
      <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 20%; color: #000000;"> </div>
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          <td style="width: 49.17%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">England and Wales</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom;">&#160;</td>
          <td style="width: 49.16%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Not applicable</div>
          </td>
        </tr>
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          <td style="width: 49.17%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">(State or other jurisdiction of Incorporation or organization)</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom;">&#160;</td>
          <td style="width: 49.16%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">(I.R.S. Employer Identification No.)</div>
          </td>
        </tr>

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    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">92 Park Drive</div>
    <div style="text-align: center; font-weight: bold;">Milton Park</div>
    <div style="text-align: center; font-weight: bold;">Abingdon, Oxfordshire OX14 4RY</div>
    <div style="text-align: center; font-weight: bold;">United Kingdom</div>
    <div style="text-align: center; font-weight: bold;">(Address of principal executive offices) (Zip code)</div>
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      <div><br>
      </div>
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        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
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    <div style="text-align: center; font-weight: bold;">Immunocore Holdings plc 2021 Equity Incentive Plan, with Non-Employee Sub-Plan</div>
    <div style="text-align: center; font-weight: bold;">(Full title of the plan)</div>
    <div>
      <div><br>
      </div>
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    <div style="text-align: center; font-weight: bold;">Immunocore, LLC</div>
    <div style="text-align: center;">Six Tower Bridge, Suite 200</div>
    <div style="text-align: center;">181 Washington Street</div>
    <div style="text-align: center;">Conshohocken, Pennsylvania 19428</div>
    <div style="text-align: center;">United States</div>
    <div style="text-align: center;">Tel: +1 484 534 5261</div>
    <div style="text-align: center; font-weight: bold;">(Name and address of agent for service) (Telephone number, including area code, of agent for service)</div>
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      <div><br>
      </div>
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    <div style="text-align: center; font-style: italic; font-weight: bold;">Copies to:</div>
    <div>&#160;</div>
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      <table cellspacing="0" cellpadding="0" border="0" id="zdff23a995dbd4a6483b61b666b0982d2" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 33.31%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Divakar Gupta</div>
            </td>
            <td style="width: 34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Lily Hepworth</div>
            </td>
            <td style="width: 33.34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Claire Keast-Butler</div>
            </td>
          </tr>
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            <td style="width: 33.31%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Courtney T. Thorne</div>
            </td>
            <td style="width: 34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">General Counsel</div>
            </td>
            <td style="width: 33.34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Cooley (UK) LLP</div>
            </td>
          </tr>
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            <td style="width: 33.31%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Cooley LLP</div>
            </td>
            <td style="width: 34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Immunocore Holdings plc</div>
            </td>
            <td style="width: 33.34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">22 Bishopsgate</div>
            </td>
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            <td style="width: 33.31%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">55 Hudson Yards</div>
            </td>
            <td style="width: 34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">92 Park Drive</div>
            </td>
            <td style="width: 33.34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">London EC2N 4BQ</div>
            </td>
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            <td style="width: 33.31%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">New York, New York 10001</div>
            </td>
            <td style="width: 34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Milton Park</div>
            </td>
            <td style="width: 33.34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">United Kingdom</div>
            </td>
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            <td style="width: 33.31%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">+1 212 479 6000</div>
            </td>
            <td style="width: 34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Abingdon, Oxfordshire OX14 4RY</div>
            </td>
            <td style="width: 33.34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">+44 20 7583 4055</div>
            </td>
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            <td style="width: 33.31%; vertical-align: top;">&#160;</td>
            <td style="width: 34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">United Kingdom</div>
            </td>
            <td style="width: 33.34%; vertical-align: top;">&#160;</td>
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            <td style="width: 33.31%; vertical-align: top;">&#160;</td>
            <td style="width: 34%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Tel: +44 12 3543 8600</div>
            </td>
            <td style="width: 33.34%; vertical-align: top;">&#160;</td>
          </tr>

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    </div>
    <div>&#160;</div>
    <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
      filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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          <td style="width: 20.38%; vertical-align: bottom;">
            <div>Large accelerated filer</div>
          </td>
          <td style="width: 1.75%; vertical-align: bottom;">&#160;</td>
          <td style="width: 45.01%; vertical-align: bottom;">
            <div>&#9746;</div>
          </td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 26.28%; vertical-align: bottom;">
            <div>Accelerated filer</div>
          </td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 3.04%; vertical-align: bottom;">
            <div>&#9744;</div>
          </td>
        </tr>
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          <td style="width: 20.38%; vertical-align: bottom;">
            <div>Non-accelerated filer</div>
          </td>
          <td style="width: 1.75%; vertical-align: bottom;">&#160;</td>
          <td style="width: 45.01%; vertical-align: bottom;">
            <div>&#9744;</div>
          </td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 26.28%; vertical-align: bottom;">
            <div>Smaller reporting company</div>
          </td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 3.04%; vertical-align: bottom;">
            <div>&#9744;</div>
          </td>
        </tr>
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          <td style="width: 20.38%; vertical-align: top;">&#160;</td>
          <td style="width: 1.75%; vertical-align: bottom;">&#160;</td>
          <td style="width: 45.01%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 26.28%; vertical-align: top;">
            <div>Emerging growth company</div>
          </td>
          <td style="width: 1.76%; vertical-align: bottom;">&#160;</td>
          <td style="width: 3.04%; vertical-align: top;">
            <div>&#9744;</div>
          </td>
        </tr>

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    <div>&#160;</div>
    <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. &#9744;</div>
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      <div><br>
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      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E</div>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: justify; text-indent: 24.5pt; font-size: 12pt;"><font style="font-size: 10pt; color: #000000;">Pursuant to General Instruction E to Form S-8, Immunocore Holdings plc (the &#8220;</font><font style="font-size: 10pt; font-weight: bold; font-style: italic; color: #000000;">Registrant</font><font style="font-size: 10pt; color: #000000;">&#8221;) is filing this Registration Statement on Form S-8 (the &#8220;</font><font style="font-size: 10pt; font-weight: bold; font-style: italic; color: #000000;">S-8 Registration Statement</font><font style="font-size: 10pt; color: #000000;">&#8221;) with the Securities and Exchange Commission (the &#8220;</font><font style="font-size: 10pt; font-weight: bold; font-style: italic; color: #000000;">Commission</font><font style="font-size: 10pt; color: #000000;">&#8221;) to register 2,404,418 additional ordinary shares, nominal value &#163;0.002 per share (the &#8220;</font><font style="font-size: 10pt; font-weight: bold; font-style: italic; color: #000000;">Ordinary Shares</font><font style="font-size: 10pt; color: #000000;">&#8221;), of the Registrant under the Immunocore Holdings plc 2021 Equity Incentive Plan, including Non-Employee Sub Plan to the Immunocore Holdings plc 2021 Equity Incentive Plan (the &#8220;</font><font style="font-size: 10pt; font-weight: bold; font-style: italic; color: #000000;">2021 Plan</font><font style="font-size: 10pt; color: #000000;">&#8221;), pursuant to the provisions of the 2021 Plan providing for an automatic increase in the number of
          Ordinary Shares reserved and available for issuance under the 2021 Plan on January 1, 2023. In accordance with the instructional note to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of the Form S-8 has
          been omitted from this Registration Statement.</font></div>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">INCORPORATION BY REFERENCE OF CONTENTS OF</div>
    </div>
    <div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENTS ON FORM S-8</div>
    </div>
    <div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 24.5pt; color: #000000;">This S-8 Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a Registration Statement of
        the Registrant on Form S-8 relating to the same benefit plan is effective.</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 24.5pt; color: #000000;">The Registrant previously registered Ordinary Shares for issuance under the 2021 Plan under Registration Statements on Form S-8 filed with the Commission on April 12, 2021 (File
        No. 333-255182) and May 17, 2022 (File No. 333-265000).</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 24.5pt; color: #000000;">Pursuant to General Instruction E to Form S-8, this S-8 Registration Statement hereby incorporates by reference the contents of the Registration Statements referenced above.</div>
    </div>
    <div><br>
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          <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 8.</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-weight: bold;">Exhibits.</div>
          </td>
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    <div>&#160;</div>
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          <td style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td style="width: 1%; vertical-align: bottom;"><br>
          </td>
          <td style="width: 53%; vertical-align: bottom;"><br>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" colspan="7">
            <div>
              <div style="text-align: center; font-weight: bold;">Incorporated by Reference</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Exhibit</div>
            <div>
              <div style="text-align: center; font-weight: bold;">Number</div>
            </div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 53%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: center; font-weight: bold;">Description</div>
            </div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Schedule</div>
            <div>
              <div style="text-align: center; font-weight: bold;">Form</div>
            </div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: center; font-weight: bold;">File Number</div>
            </div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: center; font-weight: bold;">Exhibit</div>
            </div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 12%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="text-align: center; font-weight: bold;">Filing Date</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">4.1</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
          <td style="width: 53%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt; color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex1-1.htm">Articles of Association of Immunocore Holdings plc.</a></div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">20-F</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-39992</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">1.1</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 12%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3/25/21</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
          <td style="width: 53%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 12%; vertical-align: bottom;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">4.2</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 53%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt; color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex2-2.htm">Deposit Agreement.</a></div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">20-F</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-39992</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">2.2</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 12%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3/25/21</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
          <td style="width: 53%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 12%; vertical-align: bottom;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">4.3</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
          <td style="width: 53%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt; color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex2-2.htm">Form of American Depositary Receipt (included in Exhibit 4.1).</a></div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">20-F</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-39992</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">2.3</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 12%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3/25/21</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
          <td style="width: 53%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 12%; vertical-align: bottom;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10050696_ex5-1.htm">5.1*</a></div>
          </td>
          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 53%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt; color: rgb(0, 0, 0);">Opinion of Cooley (UK) LLP.</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 12%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
          <td style="width: 53%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 12%; vertical-align: bottom;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10050696_ex23-1.htm">23.1*</a></div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
          <td style="width: 53%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt; color: rgb(0, 0, 0);">Consent of KPMG LLP, independent registered public accounting firm</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 12%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
          <td style="width: 53%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 12%; vertical-align: bottom;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10050696_ex5-1.htm">23.2*</a></div>
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          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 53%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt; color: rgb(0, 0, 0);">Consent of Cooley (UK) LLP (included in Exhibit 5.1).</div>
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          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 12%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
          <td style="width: 53%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 12%; vertical-align: bottom;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#POWEROFATTORNEY">24.1*</a></div>
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          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255); color: rgb(0, 0, 0);">&#160;</td>
          <td style="width: 53%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt; color: rgb(0, 0, 0);">Power of Attorney (included on the signature page of this Registration Statement)</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 12%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
          <td style="width: 53%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 12%; vertical-align: bottom;" rowspan="1">&#160;</td>
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        <tr>
          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);">99.1</div>
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          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 53%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt; color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/1671927/000114036121009904/brhc10022122_ex4-20.htm">Immunocore Holdings plc 2021 Equity Incentive Plan, including
                Non-Employee Sub-Plan to the Immunocore Holdings plc 2021 Equity Incentive Plan.</a></div>
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          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">20-F</div>
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          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">001-39992</div>
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          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">4.20</div>
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          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 12%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center;">3/25/21</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top;" rowspan="1"><br>
          </td>
          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0);" rowspan="1">&#160;</td>
          <td style="width: 53%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 12%; vertical-align: bottom;" rowspan="1">&#160;</td>
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          <td style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10050696_ex107.htm">107</a></div>
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          <td style="width: 1%; vertical-align: bottom; color: rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 53%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 9pt; color: rgb(0, 0, 0);">Filing Fee Table</div>
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          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 12%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
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      <div><br>
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            <div>Filed herewith.</div>
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    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 18pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
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            <div style="font-weight: bold;">IMMUNOCORE HOLDINGS PLC</div>
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          <td style="width: 49.9%; vertical-align: top;">&#160;</td>
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          <td style="width: 46.9%; vertical-align: middle;">&#160;</td>
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        <tr>
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            <div>By:</div>
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            <div style="color: rgb(0, 0, 0);">/s/ Bahija Jallal, Ph.D.</div>
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          <td style="width: 49.9%; vertical-align: top;">&#160;</td>
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          <td style="width: 49.9%; vertical-align: top;">&#160;</td>
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            <div style="margin-left: 9pt;">Chief Executive Officer</div>
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    <div>&#160;</div>
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    <div style="text-align: justify; text-indent: 18pt;">KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Bahija Jallal, Brian Di Donato and Lily Hepworth, and each or any one of them, his or her
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      this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and
      authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said
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    <div>&#160;</div>
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As filed with the Securities and Exchange Commission on April 6, 2023
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Immunocore Holdings plc
(Exact name of registrant as specified in its charter)
England and Wales
Not applicable
(State or other jurisdiction of Incorporation or organization)
(I.R.S. Employer Identification No.)
92 Park Drive
Milton Park
Abingdon, Oxfordshire OX14 4RY
United Kingdom
(Address of principal executive offices) (Zip code)
Immunocore Holdings plc 2021 Equity Incentive Plan, with Non-Employee Sub-Plan
(Full title of the plan)
Immunocore, LLC
Six Tower Bridge, Suite 200
181 Washington Street
Conshohocken, Pennsylvania 19428
United States
Tel: +1 484 534 5261
(Name and address of agent for service) (Telephone number, including area code, of agent for service)
Copies to:
Divakar Gupta
Lily Hepworth
Claire Keast-Butler
Courtney T. Thorne
General Counsel
Cooley (UK) LLP
Cooley LLP
Immunocore Holdings plc
22 Bishopsgate
55 Hudson Yards
92 Park Drive
London EC2N 4BQ
New York, New York 10001
Milton Park
United Kingdom
+1 212 479 6000
Abingdon, Oxfordshire OX14 4RY
+44 20 7583 4055
United Kingdom
Tel: +44 12 3543 8600
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
      filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☒
Accelerated filer
☐
Non-accelerated filer
☐
Smaller reporting company
☐
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. ☐
REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E
Pursuant to General Instruction E to Form S-8, Immunocore Holdings plc (the "
Registrant
") is filing this Registration Statement on Form S-8 (the "
S-8 Registration Statement
") with the Securities and Exchange Commission (the "
Commission
") to register 2,404,418 additional ordinary shares, nominal value £0.002 per share (the "
Ordinary Shares
"), of the Registrant under the Immunocore Holdings plc 2021 Equity Incentive Plan, including Non-Employee Sub Plan to the Immunocore Holdings plc 2021 Equity Incentive Plan (the "
2021 Plan
"), pursuant to the provisions of the 2021 Plan providing for an automatic increase in the number of
          Ordinary Shares reserved and available for issuance under the 2021 Plan on January 1, 2023. In accordance with the instructional note to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of the Form S-8 has
          been omitted from this Registration Statement.
INCORPORATION BY REFERENCE OF CONTENTS OF
REGISTRATION STATEMENTS ON FORM S-8
This S-8 Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a Registration Statement of
        the Registrant on Form S-8 relating to the same benefit plan is effective.
The Registrant previously registered Ordinary Shares for issuance under the 2021 Plan under Registration Statements on Form S-8 filed with the Commission on April 12, 2021 (File
        No. 333-255182) and May 17, 2022 (File No. 333-265000).
Pursuant to General Instruction E to Form S-8, this S-8 Registration Statement hereby incorporates by reference the contents of the Registration Statements referenced above.
Item 8.
Exhibits.
Incorporated by Reference
Exhibit
Number
Description
Schedule
Form
File Number
Exhibit
Filing Date
4.1
Articles of Association of Immunocore Holdings plc.
20-F
001-39992
1.1
3/25/21
4.2
Deposit Agreement.
20-F
001-39992
2.2
3/25/21
4.3
Form of American Depositary Receipt (included in Exhibit 4.1).
20-F
001-39992
2.3
3/25/21
5.1*
Opinion of Cooley (UK) LLP.
23.1*
Consent of KPMG LLP, independent registered public accounting firm
23.2*
Consent of Cooley (UK) LLP (included in Exhibit 5.1).
24.1*
Power of Attorney (included on the signature page of this Registration Statement)
99.1
Immunocore Holdings plc 2021 Equity Incentive Plan, including
                Non-Employee Sub-Plan to the Immunocore Holdings plc 2021 Equity Incentive Plan.
20-F
001-39992
4.20
3/25/21
107
Filing Fee Table
*
Filed herewith.
1
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8
      and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Oxford, United Kingdom, on the sixth day of April, 2023.
IMMUNOCORE HOLDINGS PLC
By:
/s/ Bahija Jallal, Ph.D.
Bahija Jallal, Ph.D.
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Bahija Jallal, Brian Di Donato and Lily Hepworth, and each or any one of them, his or her
      true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to
      this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and
      authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said
      attorneys-in-fact and agents, or any of them, or their or his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
SIGNATURE
TITLE
DATE
/s/ Bahija Jallal, Ph.D.
Chief Executive Officer and Director
April 6, 2023
Bahija Jallal, Ph.D.
(Principal Executive Officer)
/s/ Brian Di Donato
Chief Financial Officer
April 6, 2023
Brian Di Donato
(Principal Financial Officer and Principal Accounting Officer)
/s/
Professor Sir John Bell
Professor Sir John Bell
Chairman of the Board of Directors
April 6, 2023
/s/ Travis Coy
Travis Coy
Director
April 6, 2023
/s/
Roy S. Herbst, M.D., Ph.D.
Roy S. Herbst, M.D., Ph.D.
Director
April 6, 2023
/s/ Robert Perez
Robert Perez
Director
April 6, 2023
2
/s/ Kristine Peterson
Kristine Peterson
Director
April 6, 2023
/s/
Professor Sir Peter Ratcliffe
Professor Sir Peter Ratcliffe
Director
April 6, 2023
/s/
Siddharth Kaul
Siddharth Kaul
Director
April 6, 2023
Immunocore, LLC
April 6
, 2023
By:
/s/ Bahija Jallal, Ph.D.
Authorized Representative in the United States
Name: Bahija Jallal, Ph.D.
Title: Authorized Signatory
3