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    <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on May 31, 2022</div>
    <div>
      <div>&#160;</div>
      <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
      <div>
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      <div style="text-align: center; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; font-size: 12pt; font-weight: bold;">WASHINGTON, D.C. 20549</div>
      <div>&#160;</div>
      <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S&#8209;8</div>
      <div>&#160;</div>
      <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</div>
      <div>&#160;</div>
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            <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 24pt;">
              <div style="text-align: center; font-weight: bold;">AXOGEN, INC.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="text-align: center;">(Exact name of registrant as specified in its charter)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
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            <td style="width: 50%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Minnesota</div>
            </td>
            <td style="width: 50%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">41&#8209;1301878</div>
            </td>
          </tr>
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            <td style="width: 50%; vertical-align: bottom;">
              <div style="text-align: center;">(State or other jurisdiction of incorporation or organization)</div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center;">(I.R.S. Employer Identification No.)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: bottom;">&#160;</td>
            <td style="width: 50%; vertical-align: bottom;">&#160;</td>
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            <td style="width: 50%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">13631 Progress Boulevard, Suite 400</div>
              <div style="text-align: center; font-weight: bold;">Alachua, Florida</div>
            </td>
            <td style="width: 50%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">32615</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: bottom;">
              <div style="text-align: center;">(Address of Principal Executive Offices)</div>
            </td>
            <td style="width: 50%; vertical-align: bottom;">
              <div style="text-align: center;">(Zip Code)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" id="z89b60b8ef5d0480aa3f8b722e4cbfcb5" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
              <div style="text-align: center; font-weight: bold;">AXOGEN, INC. SECOND AMENDED AND RESTATED</div>
              <div style="text-align: center; font-weight: bold;">2019 LONG-TERM INCENTIVE PLAN</div>
            </td>
          </tr>
          <tr>
            <td style="width: 100%; vertical-align: top;">
              <div style="text-align: center;">(Full title of the plan)</div>
            </td>
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      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="z5e2935d50a5940a0abc381e6e3028192" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 50%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Brad Ottinger</div>
              <div style="text-align: center; font-weight: bold;">General Counsel</div>
              <div style="text-align: center; font-weight: bold;">Axogen, Inc.</div>
              <div style="text-align: center; font-weight: bold;">13631 Progress Boulevard, Suite 400</div>
              <div style="text-align: center; font-weight: bold;">Alachua, Florida&#8194;32615</div>
              <div style="text-align: center; font-weight: bold;">(386) 462&#8209;6800</div>
            </td>
            <td style="width: 50%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Fahd M.T. Riaz, Esq.</div>
              <div style="text-align: center; font-weight: bold;">DLA Piper LLP (US)</div>
              <div style="text-align: center; font-weight: bold;">1650 Market Street, Suite 4900</div>
              <div style="text-align: center; font-weight: bold;">Philadelphia, Pennsylvania 19103</div>
              <div style="text-align: center; font-weight: bold;">(215) 656 3300</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: bottom;">
              <div style="text-align: center;">(Name, address, telephone number, including</div>
              <div style="text-align: center;">area code, of agent for service)</div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center;">(Copy to)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large
        accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b&#8209;2 of the Exchange Act.</div>
      <div>&#160;</div>
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            <td style="width: 70%; vertical-align: top;">
              <div style="text-align: justify;">Large accelerated filer &#9744;</div>
            </td>
            <td style="width: 30%; vertical-align: top;">
              <div style="text-align: justify;">Accelerated filer &#9745;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 70%; vertical-align: top;">
              <div style="text-align: justify;">Non-accelerated filer &#9744;</div>
            </td>
            <td style="width: 30%; vertical-align: top;">
              <div style="text-align: justify;">Smaller reporting company &#9744;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 70%; vertical-align: top;">&#160;</td>
            <td style="width: 30%; vertical-align: top;">
              <div style="text-align: justify;">Emerging growth company &#9744;</div>
            </td>
          </tr>

      </table>
      <div style="text-align: justify;"> <br>
      </div>
      <div style="text-align: justify;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
        Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
      <div>&#160;</div>
      <div>
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      <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
      <div>&#160; <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt;">This Registration Statement <font style="color: rgb(0, 0, 0);">relates solely to the registration of </font>an additional 2,500,000 shares of Axogen, Inc. (the &#8220;Registrant&#8221;) common stock that
        became available for issuance pursuant to the Axogen, Inc. Second Amended and Restated 2019 Long-Term Incentive Plan and for which a Registration Statement of the Registrant on Form S-8 relating to the same employee benefit plan is effective.<font style="color: rgb(0, 0, 0);"> </font></div>
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      <div style="text-align: center;"><font style="font-weight: bold;">INCORPORATION BY REFERENCE OF CONTENTS OF REGISTRATION STATEMENTS ON FORM S-8</font><br>
      </div>
      <div style="text-align: center;"><br>
        <div style="text-align: left;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Pursuant to General Instruction E of Form S-8, this Registration Statement hereby incorporates by reference the contents of (i) the registration statement on Form S-8 filed by the Registrant with the
          Securities and Exchange Commission (the &#8220;Commission&#8221;) on <a href="https://www.sec.gov/Archives/edgar/data/805928/000155837019008297/s-8.htm">August 22, 2019</a> (Registration No. 333-233416) and (ii) the registration statement on Form S-8 filed
          by the Registrant with the Commission on <a href="https://www.sec.gov/Archives/edgar/data/805928/000119312521157043/d195760ds8.htm">May 11, 2021</a> (Registration No. 333-255992).</div>
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            <td style="width: 36pt; vertical-align: top;">Item 8.</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div><u>Exhibits</u></div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" border="0" id="z70f7565cd47f4b57820d4c7bd6f8741f" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 10%; vertical-align: bottom;">
              <div><u>EXHIBIT</u></div>
              <div><u> NUMBER</u></div>
            </td>
            <td style="width: 90%; vertical-align: bottom;">
              <div><u>DESCRIPTION</u></div>
            </td>
          </tr>
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            <td style="width: 10%; vertical-align: bottom;" rowspan="1">&#160;</td>
            <td style="width: 90%; vertical-align: bottom;" rowspan="1">&#160;</td>
          </tr>
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            <td style="width: 10%; vertical-align: top;">
              <div style="text-align: justify;"><a href="https://www.sec.gov/Archives/edgar/data/805928/000155837018001268/axgn-20171231ex429a90a9a.htm">4.1</a></div>
            </td>
            <td style="width: 90%; vertical-align: top;">
              <div style="text-align: justify;">Registration Rights Agreement, dated as of August 26, 2015, between the Company and EW Healthcare Partners L.P., formerly named Essex Woodlands Fund IX, L.P. (incorporated by reference to Exhibit 4.2 to the
                annual report on Form 10-K filed on February 28, 2018).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 90%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top;">
              <div style="text-align: justify;"><a href="brhc10038163_ex5-1.htm">5.1</a></div>
            </td>
            <td style="width: 90%; vertical-align: top;">
              <div style="text-align: justify;">Opinion of DLA Piper LLP &#8224;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 90%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top;">
              <div style="text-align: justify;"><a href="brhc10038163_ex5-1.htm">23.1</a></div>
            </td>
            <td style="width: 90%; vertical-align: top;">
              <div style="text-align: justify;">Consent of DLA Piper LLP (contained in Exhibit 5.1). &#8224;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 90%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
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            <td style="width: 10%; vertical-align: top;">
              <div style="text-align: justify;"><a href="brhc10038163_ex23-2.htm">23.2</a></div>
            </td>
            <td style="width: 90%; vertical-align: top;">
              <div style="text-align: justify;">Consent of Deloitte &amp; Touche LLP, the Registrant&#8217;s Independent Registered Public Accounting Firm (filed herewith). &#8224;</div>
            </td>
          </tr>
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            <td style="width: 10%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 90%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
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            <td style="width: 10%; vertical-align: top;">
              <div style="text-align: justify;"><a href="#POWEROFATTORNEY">24.1</a></div>
            </td>
            <td style="width: 90%; vertical-align: top;">
              <div style="text-align: justify;">Power of Attorney (included on signature page to this Registration Statement).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 90%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top;">
              <div style="text-align: justify;"><a href="https://www.sec.gov/Archives/edgar/data/805928/000080592822000051/axgn_proxyx20211.htm">99.1</a></div>
            </td>
            <td style="width: 90%; vertical-align: top;">
              <div style="text-align: justify;">Axogen, Inc. Second Amended and Restated 2019 Long-Term Incentive Plan (incorporated by reference from Appendix A of the Registrant&#8217;s Proxy Statement on DEF14A dated April 14, 2022 (No. 001-36046)).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 90%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top;">
              <div style="text-align: justify;"><a href="brhc10038163_ex107.htm">107</a></div>
            </td>
            <td style="width: 90%; vertical-align: top;">
              <div style="text-align: justify;">Filing Fee Table. &#8224;</div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
      <div>&#8224;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Filed herewith.</div>
      <div> <br>
      </div>
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      <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S&#8209;8 and has
        duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Alachua, State of Florida, on May 31, 2022.</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" border="0" id="z0f9d2f720a364558bcb3cdb3156f954f" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="vertical-align: top;" colspan="2">
              <div style="font-weight: bold;">Axogen, Inc.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top;">
              <div>By:</div>
            </td>
            <td style="width: 47%; vertical-align: top; border-bottom: 2px solid black;">
              <div>/s/ Karen Zaderej</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 47%; vertical-align: top;">
              <div>Name: Karen Zaderej</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 47%; vertical-align: top;">
              <div>Title: Chief Executive Officer</div>
            </td>
          </tr>

      </table>
      <div style="text-align: center; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints each of Karen Zaderej, Peter J. Mariani and Brad Ottinger his or her true and lawful
        attorney-in-fact, with full power of substitution and resubstitution for him or her and in his or her name, place and stead, in any and all capacities to sign any and all amendments including post-effective amendments to this Registration Statement
        on Form S&#8209;8 (including, without limitation, any additional registration statement filed pursuant to Rule 462 under the Securities Act of 1933), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the
        Securities and Exchange Commission, hereby ratifying and confirming all that said attorney-in-fact or his substitute, each acting alone, may lawfully do or cause to be done by virtue thereof.</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement on Form S&#8209;8 has been signed by the following persons in the capacities and on the dates
        indicated.</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" border="0" id="z6940e4b98f2246c19d179340eabc8e16" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 35.14%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;"><u>Signature</u></div>
            </td>
            <td style="width: 45.1%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;"><u>Title</u></div>
            </td>
            <td style="width: 19.76%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;"><u>Date</u></div>
            </td>
          </tr>
          <tr>
            <td style="width: 35.14%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 45.1%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 19.76%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 35.14%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Karen Zaderej</div>
            </td>
            <td colspan="1" rowspan="2" style="width: 45.1%; vertical-align: top;">
              <div style="text-align: center;">Chief Executive Officer, President and Chairman of the Board</div>
              <div style="text-align: center;">(Principal Executive Officer)</div>
            </td>
            <td colspan="1" rowspan="2" style="width: 19.76%; vertical-align: top;">&#160;
              <div style="text-align: center;">May 31, 2022</div>
            </td>
          </tr>
          <tr>
            <td style="width: 35.14%; vertical-align: top;">
              <div style="text-align: center;">Karen Zaderej</div>
            </td>
          </tr>
          <tr>
            <td style="width: 35.14%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 45.1%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 19.76%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 35.14%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Peter J. Mariani</div>
            </td>
            <td colspan="1" rowspan="2" style="width: 45.1%; vertical-align: top;">
              <div style="text-align: center;">Executive Vice President and Chief Financial Officer (Principal</div>
              <div style="text-align: center;">Financial Officer and Principal Accounting Officer)</div>
            </td>
            <td colspan="1" rowspan="2" style="width: 19.76%; vertical-align: top;">&#160;
              <div style="text-align: center;">May 31, 2022</div>
            </td>
          </tr>
          <tr>
            <td style="width: 35.14%; vertical-align: top;">
              <div style="text-align: center;">Peter J. Mariani</div>
            </td>
          </tr>
          <tr>
            <td style="width: 35.14%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 45.1%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 19.76%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 35.14%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">/s/ Gregory G. Freitag</div>
            </td>
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            </td>
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      </table>
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[{"type": "S-8", "sequence": "1", "filename": "brhc10038163_s8.htm", "description": "S-8", "secsgml_size_bytes": 33354}]
{"company-data": {"conformed-name": "Axogen, Inc.", "cik": "0000805928", "assigned-sic": "3845", "irs-number": "411301878", "state-of-incorporation": "MN", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-265321", "film-number": "22983914"}, "business-address": {"street1": "13631 PROGRESS BLVD.", "street2": "SUITE 400", "city": "ALACHUA", "state": "FL", "zip": "32615", "phone": "(386) 462-6817"}, "mail-address": {"street1": "13631 PROGRESS BLVD.", "street2": "SUITE 400", "city": "ALACHUA", "state": "FL", "zip": "32615"}, "former-company": [{"former-conformed-name": "AxoGen, Inc.", "date-changed": "20111004"}, {"former-conformed-name": "LECTEC CORP /MN/", "date-changed": "19920703"}]}
As filed with the Securities and Exchange Commission on May 31, 2022
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S‑8
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
AXOGEN, INC.
(Exact name of registrant as specified in its charter)
Minnesota
41‑1301878
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
13631 Progress Boulevard, Suite 400
Alachua, Florida
32615
(Address of Principal Executive Offices)
(Zip Code)
AXOGEN, INC. SECOND AMENDED AND RESTATED
2019 LONG-TERM INCENTIVE PLAN
(Full title of the plan)
Brad Ottinger
General Counsel
Axogen, Inc.
13631 Progress Boulevard, Suite 400
Alachua, Florida 32615
(386) 462‑6800
Fahd M.T. Riaz, Esq.
DLA Piper LLP (US)
1650 Market Street, Suite 4900
Philadelphia, Pennsylvania 19103
(215) 656 3300
(Name, address, telephone number, including
area code, of agent for service)
(Copy to)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large
        accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b‑2 of the Exchange Act.
Large accelerated filer ☐
Accelerated filer ☑
Non-accelerated filer ☐
Smaller reporting company ☐
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
        Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY NOTE
This Registration Statement
relates solely to the registration of
an additional 2,500,000 shares of Axogen, Inc. (the "Registrant") common stock that
        became available for issuance pursuant to the Axogen, Inc. Second Amended and Restated 2019 Long-Term Incentive Plan and for which a Registration Statement of the Registrant on Form S-8 relating to the same employee benefit plan is effective.
INCORPORATION BY REFERENCE OF CONTENTS OF REGISTRATION STATEMENTS ON FORM S-8
Pursuant to General Instruction E of Form S-8, this Registration Statement hereby incorporates by reference the contents of (i) the registration statement on Form S-8 filed by the Registrant with the
          Securities and Exchange Commission (the "Commission") on
August 22, 2019
(Registration No. 333-233416) and (ii) the registration statement on Form S-8 filed
          by the Registrant with the Commission on
May 11, 2021
(Registration No. 333-255992).
Item 8.
Exhibits
EXHIBIT
NUMBER
DESCRIPTION
4.1
Registration Rights Agreement, dated as of August 26, 2015, between the Company and EW Healthcare Partners L.P., formerly named Essex Woodlands Fund IX, L.P. (incorporated by reference to Exhibit 4.2 to the
                annual report on Form 10-K filed on February 28, 2018).
5.1
Opinion of DLA Piper LLP †
23.1
Consent of DLA Piper LLP (contained in Exhibit 5.1). †
23.2
Consent of Deloitte & Touche LLP, the Registrant's Independent Registered Public Accounting Firm (filed herewith). †
24.1
Power of Attorney (included on signature page to this Registration Statement).
99.1
Axogen, Inc. Second Amended and Restated 2019 Long-Term Incentive Plan (incorporated by reference from Appendix A of the Registrant's Proxy Statement on DEF14A dated April 14, 2022 (No. 001-36046)).
107
Filing Fee Table. †
†          Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S‑8 and has
        duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Alachua, State of Florida, on May 31, 2022.
Axogen, Inc.
By:
/s/ Karen Zaderej
Name: Karen Zaderej
Title: Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints each of Karen Zaderej, Peter J. Mariani and Brad Ottinger his or her true and lawful
        attorney-in-fact, with full power of substitution and resubstitution for him or her and in his or her name, place and stead, in any and all capacities to sign any and all amendments including post-effective amendments to this Registration Statement
        on Form S‑8 (including, without limitation, any additional registration statement filed pursuant to Rule 462 under the Securities Act of 1933), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the
        Securities and Exchange Commission, hereby ratifying and confirming all that said attorney-in-fact or his substitute, each acting alone, may lawfully do or cause to be done by virtue thereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement on Form S‑8 has been signed by the following persons in the capacities and on the dates
        indicated.
Signature
Title
Date
/s/ Karen Zaderej
Chief Executive Officer, President and Chairman of the Board
(Principal Executive Officer)
May 31, 2022
Karen Zaderej
/s/ Peter J. Mariani
Executive Vice President and Chief Financial Officer (Principal
Financial Officer and Principal Accounting Officer)
May 31, 2022
Peter J. Mariani
/s/ Gregory G. Freitag
Director
Gregory G. Freitag
May 31, 2022
/s/ Dr. Mark Gold
Director
Dr. Mark Gold
May 31, 2022
/s/ John H. Johnson
Director
John H. Johnson
May 31, 2022
/s/
Alan M. Levine
Director
Alan M. Levine
May 31, 2022
/s/ Guido J. Neels
Director
Guido J. Neels
May 31, 2022
/s/ Paul G. Thomas
Director
Paul G. Thomas
May 31, 2022
/s/
Amy Wendell
Director
Amy Wendell
May 31, 2022