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    <div style="text-align: center; color: #000000; font-weight: bold;">As filed with the Securities and Exchange Commission on March 28, 2023</div>
    <div style="text-align: right; color: #000000; font-weight: bold;">Registration No. 333-</div>
    <div style="text-align: right; color: #000000; font-weight: bold;">
      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"> <br>
    </div>
    <div>
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;"> <br>
    </div>
    <div>
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;">Infinity Pharmaceuticals, Inc.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(Exact Name of Registrant as Specified in Its Charter)</div>
    <div>
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;">
      <div><br>
      </div>
    </div>
    <table cellspacing="0" cellpadding="0" id="z64dd8d2b56a54f9e9fcb79eadc0dd6ad" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 49%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
          </td>
          <td style="width: 2.04%; vertical-align: top;">&#160;</td>
          <td style="width: 48.96%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">33-0655706</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-weight: bold;">(State or Other Jurisdiction of</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Incorporation or Organization)</div>
          </td>
          <td style="width: 2.04%; vertical-align: top;">&#160;</td>
          <td style="width: 48.96%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-weight: bold;">(I.R.S. Employer</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Identification No.)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="za5fcb4aa75924c97ae0f189d20ec2b1a" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-weight: bold;">1100 Massachusetts Avenue, Floor 4</div>
            <div style="text-align: center; color: #000000; font-weight: bold;">Cambridge, Massachusetts</div>
          </td>
          <td style="width: 2.04%; vertical-align: top;">&#160;</td>
          <td style="width: 48.96%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">02138</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Address of Principal Executive Offices)</div>
          </td>
          <td style="width: 2.04%; vertical-align: top;">&#160;</td>
          <td style="width: 48.96%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Zip Code)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Inducement Stock Option Award</div>
    <div style="text-align: center; color: #000000;">(Full Title of the Plan)</div>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Seth A. Tasker, Esq.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Senior Vice President, Chief Business Officer</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Infinity Pharmaceuticals, Inc.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">1100 Massachusetts Avenue, Floor 4</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Cambridge, Massachusetts 02138</div>
    <div style="text-align: center; color: #000000;">(Name and Address of Agent For Service)</div>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(617) 453-1000</div>
    <div style="text-align: center; color: #000000;">(Telephone Number, Including Area Code, of Agent For Service)</div>
    <div style="text-align: center; color: #000000;"> <br>
    </div>
    <div>
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">With copies to:</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Cynthia T. Mazareas, Esq.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Wilmer Cutler Pickering Hale and Dorr LLP</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">60 State Street</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Boston, MA 02109</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Telephone: (617) 526-6000</div>
    <div style="text-align: center; color: #000000; font-weight: bold;"> <br>
    </div>
    <div>
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="color: #000000;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large
      accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <table cellspacing="0" cellpadding="0" id="z54a8db3fccc24c94bf375d68d5f9cbf9" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td nowrap="nowrap" style="width: 19.42%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Large accelerated filer</div>
          </td>
          <td style="width: 54.99%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">&#9744;</div>
          </td>
          <td style="width: 23.57%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Accelerated filer</div>
          </td>
          <td style="width: 1.91%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">&#9744;</div>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 19.42%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 54.99%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 23.57%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1.91%; vertical-align: bottom;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 19.42%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
          </td>
          <td style="width: 54.99%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">&#9746;</div>
          </td>
          <td nowrap="nowrap" style="width: 23.57%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Smaller reporting company</div>
          </td>
          <td style="width: 1.91%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">&#9746;</div>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 19.42%; vertical-align: bottom;" rowspan="1"><br>
          </td>
          <td style="width: 54.99%; vertical-align: bottom;" rowspan="1"><br>
          </td>
          <td nowrap="nowrap" style="width: 23.57%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 1.91%; vertical-align: bottom;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 19.42%; vertical-align: bottom;"><br>
          </td>
          <td style="width: 54.99%; vertical-align: bottom;"><br>
          </td>
          <td style="width: 23.57%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Emerging growth company</div>
          </td>
          <td style="width: 1.91%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">&#9744;</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="color: #000000;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section
      7(a)(2)(B) of the Securities Act. &#9744;</div>
    <div style="color: #000000;"> <br>
    </div>
    <div>
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">PART I</div>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zfddbaca15e4e4c25be75f842bc4a2038" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 1.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Plan Information.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="color: #000000;">The information required by Item 1 is included in documents sent or given to the participant in the Inducement Award covered by this registration statement pursuant to Rule 428(b)(1) of the Securities Act of 1933, as
      amended (the &#8220;Securities Act&#8221;).</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z4d2e68f190724d11a50660429444f6e9" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 2.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Registrant Information and Employee Plan Annual Information.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="margin-right: 0.75pt; margin-left: 0.75pt; color: #000000;">The written statement required by Item&#160;2 is included in documents sent or given to the participant in the Inducement Award covered by this registration statement pursuant to
      Rule&#160;428(b)(1)&#160;of the Securities Act.</div>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">PART II</div>
    <div><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z5770fd1801044839b9c9d60d454244af" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 3.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Incorporation of Documents by Reference.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="color: #000000;">The registrant is subject to the informational and reporting requirements of Sections 13(a), 14, and 15(d) of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), and in accordance therewith files reports,
      proxy statements and other information with the Securities and Exchange Commission (the &#8220;Commission&#8221;).&#160;&#160; The following documents, which are on file with the Commission, are incorporated in this registration statement by reference:</div>
    <div><br>
    </div>
    <div style="color: #000000;">(a) The Registrant&#8217;s annual Report on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001113148/000111314823000003/infi-20221231.htm">Form 10-K</a> for the year ended December 31, 2022, filed with the Commission
      on March 28, 2023;</div>
    <div><br>
    </div>
    <div style="color: #000000;">(b) All other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the document referred to in (a) above.</div>
    <div><br>
    </div>
    <div style="color: #000000;">(c) The description of the securities contained in the Registrant&#8217;s registration statements on Form 8-A filed under the Exchange Act, including any amendment or report filed for the purpose of updating such description.</div>
    <div><br>
    </div>
    <div style="color: #000000;">All documents subsequently filed by the registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that all securities offered hereby
      have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be part hereof from the date of the filing of such documents.&#160; Any statement contained in
      a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for the purposes of this registration statement to the extent that a statement contained herein or in any other subsequently filed
      document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement.&#160; Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this
      registration statement.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z35acf30aad424d249b928fdc222f0de9" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 4.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Description of Securities.</div>
          </td>
        </tr>

    </table>
    <div style="color: #000000;">Not applicable.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z78dbbd6d5d5e499abf41f6cacb3504c1" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 5.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Interests of Named Experts and Counsel.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="color: #000000;">Wilmer Cutler Pickering Hale &amp; Dorr LLP has opined as to the legality of the securities being offered by this Registration Statement.</div>
    <div style="color: #000000;"> <br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <table cellspacing="0" cellpadding="0" id="ze7703b58daa64da1b4c32ce59f0d4047" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 6.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Indemnification of Directors and Officers.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="color: #000000;">Section 145 of the DGCL provides, generally, that a corporation shall have the power to indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or
      proceeding (except actions by or in the right of the corporation) by reason of the fact that such person is or was a director, officer, employee or agent of the corporation against all expenses, judgments, fines and amounts paid in settlement
      actually and reasonably incurred by such person in connection with such action, suit or proceeding if such person acted in good faith and in a manner such person reasonably believed to be in or not opposed to the best interests of the corporation
      and, with respect to any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful. A corporation may similarly indemnify such person for expenses actually and reasonably incurred by such person in connection
      with the defense or settlement of any action or suit by or in the right of the corporation, <font style="font-style: italic;">provided</font> that such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed
      to the best interests of the corporation, and, in the case of claims, issues and matters as to which such person shall have been adjudged liable to the corporation, <font style="font-style: italic;">provided</font> that a court shall have
      determined, upon application, that, despite the adjudication of liability but in view of all of the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which such court shall deem proper.</div>
    <div><br>
    </div>
    <div style="color: #000000;">Section 102(b)(7) of the DGCL provides, generally, that our certificate of incorporation may contain a provision eliminating or limiting the personal liability of a director to the corporation or its shareholders for
      monetary damages for breach of fiduciary duty as a director, <font style="font-style: italic;">provided</font> that such provision may not eliminate or limit the liability of a director (i) for any breach of the director&#8217;s duty of loyalty to the
      corporation or its shareholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (iii) under section 174 of the DGCL, or (iv) for any transaction from which the director derived an
      improper personal benefit. No such provision may eliminate or limit the liability of a director for any act or omission occurring prior to the date when such provision became effective.</div>
    <div><br>
    </div>
    <div style="color: #000000;">The Registrant&#8217;s certificate of incorporation provides that a member of its board of directors will not be personally liable to the Registrant or its stockholders for monetary damages for breaches of their fiduciary duties
      to the Registrant or its stockholders as a director, except for liability:</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zc7bf8376f2374af0b615a7f11c4eb5af" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 18pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top; color: #000000;">&#8226;</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">for any breach of the director&#8217;s duty of loyalty to the Registrant or its stockholders;</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z76f15b3990a2453ba3e4bb183d305a81" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 18pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top; color: #000000;">&#8226;</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">for acts or omissions by the director not in good faith or which involve intentional misconduct or a knowing violation of law;</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="ze2f0c6bdf1b24fb29b0b920c31fc0a28" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 18pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top; color: #000000;">&#8226;</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">for declaring dividends or authorizing the purchase or redemption of shares in violation of Delaware law; or</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z7b176c7500c6408294d6b04105c07c18" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 18pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top; color: #000000;">&#8226;</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">for transactions where the director derived any improper personal benefit.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="color: #000000;">The Registrant&#8217;s certificate of incorporation also allows it to indemnify directors and officers to the fullest extent authorized by Delaware law.</div>
    <div><br>
    </div>
    <div style="color: #000000;">The Registrant&#8217;s bylaws provide that it shall, to the fullest extent authorized by the DGCL, indemnify its directors and executive officers; provided, however, that it may limit the extent of such indemnification by
      individual contracts with its directors and executive officers; and, provided, further, that the Registrant shall not be required to indemnify any director or executive officer in connection with any proceeding (or part thereof) initiated by such
      person or any proceeding by such person against the Registrant or its directors, officers, employees or other agents unless (i) such indemnification is expressly required to be made by law, (ii) the proceeding was authorized by the Registrant&#8217;s board
      of directors, or (iii) such indemnification is provided by the Registrant, in its board&#8217;s sole discretion, pursuant to its powers under the DGCL.</div>
    <div><br>
    </div>
    <div style="color: #000000;">The Registrant&#8217;s bylaws also permit it to maintain insurance to protect it and any director, officer, employee or agent against any liability with respect to which the Registrant would have the power to indemnify such
      persons under the DGCL. The Registrant maintains an insurance policy insuring its directors and officers against certain liabilities.</div>
    <div><br>
    </div>
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        <tr>
          <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 7.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Exemption from Registration Claimed.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="color: #000000;">Not applicable.</div>
    <div><br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <table cellspacing="0" cellpadding="0" id="z1c872e2b96c54401bd761ad08a952c00" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 8.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibits.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z0216d46d525f4b46bed00e2256d3747c" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">Number</div>
          </td>
          <td style="width: 6%; vertical-align: bottom;">&#160;</td>
          <td nowrap="nowrap" style="width: 86%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center;">Description</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle;">&#160;</td>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td style="width: 86%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1113148/000111314820000028/restatedcertificateofi.htm">4.1</a></div>
          </td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 86%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Restated Certificate of Incorporation of the Registrant, as amended (previously filed as Exhibit 3.1 to the Registrant&#8217;s Quarterly Report on Form 10-Q for the quarter ended July 30, 2020 (File No. 000-31141) and incorporated herein by
              reference).</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle;">&#160;</td>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td style="width: 86%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1113148/000111314823000003/exhibit32amendedbylaws.htm">4.2</a></div>
          </td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 86%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Amended and Restated Bylaws of the Registrant (previously filed as Exhibit 3.2 to the Registrant&#8217;s Annual Report on Form 10-K filed on March 28, 2023 (File No. 000-31141) and incorporated herein by reference).</div>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 6%; vertical-align: bottom;" rowspan="1">&#160;</td>
          <td style="width: 86%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10050177_ex5-1.htm">5.1</a></div>
          </td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 86%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Opinion of Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Registrant. Filed Herewith.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle;">&#160;</td>
          <td style="vertical-align: middle;">&#160;</td>
          <td style="vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10050177_ex5-1.htm">23.1</a></div>
          </td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 86%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.1). Filed Herewith.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle;">&#160;</td>
          <td style="vertical-align: middle;">&#160;</td>
          <td style="vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10050177_ex23-2.htm">23.2</a></div>
          </td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 86%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Consent of Ernst &amp; Young LLP, independent registered public accounting firm to the Registrant. Filed Herewith.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: middle;">&#160;</td>
          <td style="vertical-align: middle;">&#160;</td>
          <td style="vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="#POWEROFATTORNEYANDSIGNATU">24.1</a></div>
          </td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 86%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Power of attorney (included on the signature pages of this Registration Statement).</div>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 86%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1113148/000114036121026429/nt10024341x4_ex99-1.htm">99.1</a></div>
          </td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 86%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Form of Nonstatutory Stock Option Award Agreement for Inducement Grant Pursuant to Nasdaq Stock Market Rule 5635 (c)(4) (previously filed as Exhibit 99.1 to the Registrant&#8217;s Form S-8 Registration Statement filed on August 2, 2021 (File No.
              333-258360) and incorporated herein by reference).</div>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 86%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10050177_ex107.htm">107.1</a></div>
          </td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 86%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div>Filing Fee Table</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z8519da926c2a4a10aee9b1b30102089a" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 9.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Undertakings.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="color: #000000;">1. <font style="font-style: italic;"><u>Item 512(a) of Regulation S-K</u></font>. The undersigned Registrant hereby undertakes:</div>
    <div><br>
    </div>
    <div style="text-indent: 18pt; color: #000000;">(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; color: #000000;">(i) To include any prospectus required by Section 10(a)(3) of the Securities Act;</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; color: #000000;">(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the
      aggregate, represent a fundamental change in the information set forth in the registration statement; and</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; color: #000000;">(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration
      statement;</div>
    <div><br>
    </div>
    <div style="color: #000000;"><font style="font-style: italic;">provided, however,</font> that paragraphs (1)(i) and (ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports
      filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the registration statement.</div>
    <div><br>
    </div>
    <div style="text-indent: 18pt; color: #000000;">(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered
      therein, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof.</div>
    <div><br>
    </div>
    <div style="text-indent: 18pt; color: #000000;">(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
    <div><br>
    </div>
    <div style="color: #000000;">2. <font style="font-style: italic;"><u>Item 512(b) of Regulation S-K</u></font>. The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the
      Registrant&#8217;s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein,
      and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof.</div>
    <div><br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="color: #000000;">3. <font style="font-style: italic;"><u>Item 512(h) of Regulation S-K</u></font>. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons
      of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and
      is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the
      successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been
      settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</div>
    <div><br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURES</div>
    <div><br>
    </div>
    <div style="color: #000000;">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
      Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Cambridge, Commonwealth of Massachusetts, on this 28th day of March, 2023.</div>
    <div><br>
    </div>
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        <tr>
          <td style="width: 49.9%; vertical-align: top;">&#160;</td>
          <td style="width: 50.1%; vertical-align: top;" colspan="2">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">INFINITY PHARMACEUTICALS, INC.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.9%; vertical-align: top;">&#160;</td>
          <td style="width: 3.19%; vertical-align: middle;">&#160;</td>
          <td style="width: 46.9%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 49.9%; vertical-align: top;">&#160;</td>
          <td style="width: 3.19%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">By:</div>
          </td>
          <td style="width: 46.9%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0);">/s/ Lawrence E. Bloch</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.9%; vertical-align: top;">&#160;</td>
          <td style="width: 3.19%; vertical-align: top;">&#160;</td>
          <td style="width: 46.9%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">Lawrence E. Bloch, M.D., J.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.9%; vertical-align: top;">&#160;</td>
          <td style="width: 3.19%; vertical-align: top;">&#160;</td>
          <td style="width: 46.9%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0);">President</div>
          </td>
        </tr>

    </table>
    <div style="text-align: center;"><br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">POWER OF ATTORNEY AND SIGNATURES<a name="POWEROFATTORNEYANDSIGNATU"><!--Anchor--></a></div>
    <div><br>
    </div>
    <div style="color: #000000;">We, the undersigned officers and directors of Infinity Pharmaceuticals, Inc., hereby severally constitute and appoint Adelene Q. Perkins, Lawrence E. Bloch, M.D., J.D., and Seth A. Tasker, and each of them singly, our true
      and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the Registration Statement on Form S-8 filed herewith and any and all subsequent amendments to said Registration
      Statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Infinity Pharmaceuticals, Inc. to comply with the provisions of the Securities Act of 1933, as amended, and all
      requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said Registration Statement and any and all amendments thereto.</div>
    <div><br>
    </div>
    <div style="color: #000000;">Pursuant to the requirements of the Securities Act of 1933 Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</div>
    <div><br>
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          <td nowrap="nowrap" style="width: 35.33%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">Signature</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td nowrap="nowrap" style="width: 41%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">Title</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td nowrap="nowrap" style="width: 22%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">Date</div>
          </td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 41%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 22%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0);">/s/ Adelene Q. Perkins</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="2">&#160;</td>
          <td style="width: 41%; vertical-align: top;" rowspan="2">
            <div style="text-align: center; color: rgb(0, 0, 0);">Chief Executive Officer and Chair of the Board of Directors (Principal Executive Officer)</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="2">&#160;</td>
          <td nowrap="nowrap" style="width: 22%; vertical-align: top;" rowspan="2">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 28, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Adelene Q. Perkins</div>
          </td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 41%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 22%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0);">/s/ Lawrence E. Bloch</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="2">&#160;</td>
          <td style="width: 41%; vertical-align: top;" rowspan="2">
            <div style="text-align: center; color: rgb(0, 0, 0);">President (Principal Financial Officer and Principal Accounting Officer)</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="2">&#160;</td>
          <td nowrap="nowrap" style="width: 22%; vertical-align: top;" rowspan="2">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 28, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Lawrence E. Bloch, M.D., J.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 41%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 22%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0);">/s/ Samuel Agresta</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="2">&#160;</td>
          <td style="width: 41%; vertical-align: top;" rowspan="2">
            <div style="text-align: center; color: rgb(0, 0, 0);">Director</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;" rowspan="2">&#160;</td>
          <td nowrap="nowrap" style="width: 22%; vertical-align: top;" rowspan="2">
            <div style="text-align: center; color: rgb(0, 0, 0);">March 28, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Samuel Agresta, M.D., M.P.H.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 41%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 22%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35.33%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0);">/s/ David Beier</div>
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{"company-data": {"conformed-name": "INFINITY PHARMACEUTICALS, INC.", "cik": "0001113148", "assigned-sic": "2834", "irs-number": "330655706", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-270904", "film-number": "23769939"}, "business-address": {"street1": "1100 MASSACHUSETTS AVENUE", "street2": "FLOOR 4", "city": "CAMBRIDGE", "state": "MA", "zip": "02138", "phone": "6174531000"}, "mail-address": {"street1": "1100 MASSACHUSETTS AVENUE", "street2": "FLOOR 4", "city": "CAMBRIDGE", "state": "MA", "zip": "02138"}, "former-company": [{"former-conformed-name": "INFINITY PHARMACEUTICALS, INC./NEW/", "date-changed": "20060913"}, {"former-conformed-name": "DISCOVERY PARTNERS INTERNATIONAL INC", "date-changed": "20000428"}]}
As filed with the Securities and Exchange Commission on March 28, 2023
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Infinity Pharmaceuticals, Inc.
(Exact Name of Registrant as Specified in Its Charter)
Delaware
33-0655706
(State or Other Jurisdiction of
Incorporation or Organization)
(I.R.S. Employer
Identification No.)
1100 Massachusetts Avenue, Floor 4
Cambridge, Massachusetts
02138
(Address of Principal Executive Offices)
(Zip Code)
Inducement Stock Option Award
(Full Title of the Plan)
Seth A. Tasker, Esq.
Senior Vice President, Chief Business Officer
Infinity Pharmaceuticals, Inc.
1100 Massachusetts Avenue, Floor 4
Cambridge, Massachusetts 02138
(Name and Address of Agent For Service)
(617) 453-1000
(Telephone Number, Including Area Code, of Agent For Service)
With copies to:
Cynthia T. Mazareas, Esq.
Wilmer Cutler Pickering Hale and Dorr LLP
60 State Street
Boston, MA 02109
Telephone: (617) 526-6000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large
      accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section
      7(a)(2)(B) of the Securities Act. ☐
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Item 1.
Plan Information.
The information required by Item 1 is included in documents sent or given to the participant in the Inducement Award covered by this registration statement pursuant to Rule 428(b)(1) of the Securities Act of 1933, as
      amended (the "Securities Act").
Item 2.
Registrant Information and Employee Plan Annual Information.
The written statement required by Item 2 is included in documents sent or given to the participant in the Inducement Award covered by this registration statement pursuant to
      Rule 428(b)(1) of the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The registrant is subject to the informational and reporting requirements of Sections 13(a), 14, and 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and in accordance therewith files reports,
      proxy statements and other information with the Securities and Exchange Commission (the "Commission").   The following documents, which are on file with the Commission, are incorporated in this registration statement by reference:
(a) The Registrant's annual Report on
Form 10-K
for the year ended December 31, 2022, filed with the Commission
      on March 28, 2023;
(b) All other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the document referred to in (a) above.
(c) The description of the securities contained in the Registrant's registration statements on Form 8-A filed under the Exchange Act, including any amendment or report filed for the purpose of updating such description.
All documents subsequently filed by the registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that all securities offered hereby
      have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be part hereof from the date of the filing of such documents.  Any statement contained in
      a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for the purposes of this registration statement to the extent that a statement contained herein or in any other subsequently filed
      document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement.  Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this
      registration statement.
Item 4.
Description of Securities.
Not applicable.
Item 5.
Interests of Named Experts and Counsel.
Wilmer Cutler Pickering Hale & Dorr LLP has opined as to the legality of the securities being offered by this Registration Statement.
Item 6.
Indemnification of Directors and Officers.
Section 145 of the DGCL provides, generally, that a corporation shall have the power to indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or
      proceeding (except actions by or in the right of the corporation) by reason of the fact that such person is or was a director, officer, employee or agent of the corporation against all expenses, judgments, fines and amounts paid in settlement
      actually and reasonably incurred by such person in connection with such action, suit or proceeding if such person acted in good faith and in a manner such person reasonably believed to be in or not opposed to the best interests of the corporation
      and, with respect to any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful. A corporation may similarly indemnify such person for expenses actually and reasonably incurred by such person in connection
      with the defense or settlement of any action or suit by or in the right of the corporation,
provided
that such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed
      to the best interests of the corporation, and, in the case of claims, issues and matters as to which such person shall have been adjudged liable to the corporation,
provided
that a court shall have
      determined, upon application, that, despite the adjudication of liability but in view of all of the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which such court shall deem proper.
Section 102(b)(7) of the DGCL provides, generally, that our certificate of incorporation may contain a provision eliminating or limiting the personal liability of a director to the corporation or its shareholders for
      monetary damages for breach of fiduciary duty as a director,
provided
that such provision may not eliminate or limit the liability of a director (i) for any breach of the director's duty of loyalty to the
      corporation or its shareholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (iii) under section 174 of the DGCL, or (iv) for any transaction from which the director derived an
      improper personal benefit. No such provision may eliminate or limit the liability of a director for any act or omission occurring prior to the date when such provision became effective.
The Registrant's certificate of incorporation provides that a member of its board of directors will not be personally liable to the Registrant or its stockholders for monetary damages for breaches of their fiduciary duties
      to the Registrant or its stockholders as a director, except for liability:
•
for any breach of the director's duty of loyalty to the Registrant or its stockholders;
•
for acts or omissions by the director not in good faith or which involve intentional misconduct or a knowing violation of law;
•
for declaring dividends or authorizing the purchase or redemption of shares in violation of Delaware law; or
•
for transactions where the director derived any improper personal benefit.
The Registrant's certificate of incorporation also allows it to indemnify directors and officers to the fullest extent authorized by Delaware law.
The Registrant's bylaws provide that it shall, to the fullest extent authorized by the DGCL, indemnify its directors and executive officers; provided, however, that it may limit the extent of such indemnification by
      individual contracts with its directors and executive officers; and, provided, further, that the Registrant shall not be required to indemnify any director or executive officer in connection with any proceeding (or part thereof) initiated by such
      person or any proceeding by such person against the Registrant or its directors, officers, employees or other agents unless (i) such indemnification is expressly required to be made by law, (ii) the proceeding was authorized by the Registrant's board
      of directors, or (iii) such indemnification is provided by the Registrant, in its board's sole discretion, pursuant to its powers under the DGCL.
The Registrant's bylaws also permit it to maintain insurance to protect it and any director, officer, employee or agent against any liability with respect to which the Registrant would have the power to indemnify such
      persons under the DGCL. The Registrant maintains an insurance policy insuring its directors and officers against certain liabilities.
Item 7.
Exemption from Registration Claimed.
Not applicable.
Item 8.
Exhibits.
Number
Description
4.1
Restated Certificate of Incorporation of the Registrant, as amended (previously filed as Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q for the quarter ended July 30, 2020 (File No. 000-31141) and incorporated herein by
              reference).
4.2
Amended and Restated Bylaws of the Registrant (previously filed as Exhibit 3.2 to the Registrant's Annual Report on Form 10-K filed on March 28, 2023 (File No. 000-31141) and incorporated herein by reference).
5.1
Opinion of Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Registrant. Filed Herewith.
23.1
Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.1). Filed Herewith.
23.2
Consent of Ernst & Young LLP, independent registered public accounting firm to the Registrant. Filed Herewith.
24.1
Power of attorney (included on the signature pages of this Registration Statement).
99.1
Form of Nonstatutory Stock Option Award Agreement for Inducement Grant Pursuant to Nasdaq Stock Market Rule 5635 (c)(4) (previously filed as Exhibit 99.1 to the Registrant's Form S-8 Registration Statement filed on August 2, 2021 (File No.
              333-258360) and incorporated herein by reference).
107.1
Filing Fee Table
Item 9.
Undertakings.
1.
Item 512(a) of Regulation S-K
. The undersigned Registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
(i) To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the
      aggregate, represent a fundamental change in the information set forth in the registration statement; and
(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration
      statement;
provided, however,
that paragraphs (1)(i) and (ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports
      filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the registration statement.
(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered
      therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
2.
Item 512(b) of Regulation S-K
. The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the
      Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein,
      and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
3.
Item 512(h) of Regulation S-K
. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons
      of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and
      is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the
      successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been
      settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
      Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Cambridge, Commonwealth of Massachusetts, on this 28th day of March, 2023.
INFINITY PHARMACEUTICALS, INC.
By:
/s/ Lawrence E. Bloch
Lawrence E. Bloch, M.D., J.D.
President
POWER OF ATTORNEY AND SIGNATURES
We, the undersigned officers and directors of Infinity Pharmaceuticals, Inc., hereby severally constitute and appoint Adelene Q. Perkins, Lawrence E. Bloch, M.D., J.D., and Seth A. Tasker, and each of them singly, our true
      and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the Registration Statement on Form S-8 filed herewith and any and all subsequent amendments to said Registration
      Statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Infinity Pharmaceuticals, Inc. to comply with the provisions of the Securities Act of 1933, as amended, and all
      requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said Registration Statement and any and all amendments thereto.
Pursuant to the requirements of the Securities Act of 1933 Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Adelene Q. Perkins
Chief Executive Officer and Chair of the Board of Directors (Principal Executive Officer)
March 28, 2023
Adelene Q. Perkins
/s/ Lawrence E. Bloch
President (Principal Financial Officer and Principal Accounting Officer)
March 28, 2023
Lawrence E. Bloch, M.D., J.D.
/s/ Samuel Agresta
Director
March 28, 2023
Samuel Agresta, M.D., M.P.H.
/s/ David Beier
Director
March 28, 2023
David Beier, J.D.
/s/ Anthony B. Evnin
Director
March 28, 2023
Anthony B. Evnin, Ph.D.
/s/ Richard Gaynor
Director
March 28, 2023
Richard Gaynor, M.D.
/s/ Sujay R. Kango
Director
March 28, 2023
Sujay R. Kango
/s/ Brian Schwartz
Director
March 28, 2023
Brian Schwartz, M.D.
/s/ Norman C. Selby
Director
March 28, 2023
Norman C. Selby