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      <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;" align="center">As filed with the Securities and Exchange Commission
      on May 19, 2023</div>
    <div style="text-align: right; color: #000000; font-weight: bold;">Registration No. 333-</div>
    <div>
      <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
    </div>
    <div style="text-align: center; color: #000000; font-size: 8pt; font-weight: bold;">&#160;</div>
    <div style="text-align: center; color: #000000; font-size: 18pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="color: #000000; font-size: 8pt;">&#160;</div>
    <div style="text-align: center; color: #000000; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="color: #000000; font-size: 8pt;">&#160;</div>
    <div style="text-align: center; color: #000000; font-size: 12pt; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; color: #000000; font-size: 12pt; font-weight: bold;">UNDER</div>
    <div style="text-align: center; color: #000000; font-size: 12pt; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div style="color: #000000; font-size: 8pt; font-weight: bold;">&#160;</div>
    <div style="text-align: center; color: #000000; font-size: 18pt; font-weight: bold;">INSMED INCORPORATED</div>
    <div style="text-align: center;">(Exact name of registrant as specified in its charter)</div>
    <div style="color: #000000; font-size: 8pt;">&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z72941105ce0e451284c103e6b3340ca9" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-weight: bold;">Virginia</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-weight: bold;">54-1972729</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center;">(State or other jurisdiction of incorporation or<br>
              organization)</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center;">(I.R.S. Employer Identification No.)</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>

    </table>
    <div style="color: #000000; font-size: 8pt;">&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">700 US Highway 202/206<br>
      Bridgewater, New Jersey 08807</div>
    <div style="text-align: center;">(Address of Principal Executive Offices including zip code)</div>
    <div style="color: #000000; font-size: 8pt;">&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Insmed Incorporated Amended and Restated 2019 Incentive Plan</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Insmed Incorporated Non-Qualified Stock Option Inducement Awards</div>
    <div style="text-align: center;">(Full title of the plans)</div>
    <div style="color: #000000; font-size: 8pt;">&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Michael A. Smith, Esq.</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Insmed Incorporated<br>
      General Counsel, Senior Vice President</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">700 US Highway 202/206</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Bridgewater, New Jersey 08807</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">(908) 977-9900</div>
    <div style="text-align: center;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
    <div style="color: #000000; font-size: 8pt;">&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Copies of all communications, including all communications sent to the agent for service, should be sent to:</div>
    <div style="color: #000000; font-size: 8pt;">&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">Michael J. Riella, Esq.</div>
    <div style="text-align: center;">Covington &amp; Burling LLP</div>
    <div style="text-align: center;">One CityCenter<br>
      850 Tenth St. NW<br>
      Washington, DC 20001<br>
      (202) 662-6000</div>
    <div style="color: #000000; font-size: 8pt;">&#160;</div>
    <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
      filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act:</div>
    <div style="color: #000000; font-size: 8pt;">&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z8f1d20225fc145ba960a207406a491ec" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 17.97%; vertical-align: top;">
            <div>Large accelerated filer &#9746;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2.53%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 23.98%; vertical-align: top;">
            <div>Accelerated filer &#9744;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2.53%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 23.98%; vertical-align: top;">
            <div>Non-accelerated filer &#9744;</div>
          </td>
          <td style="width: 2.53%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 23.95%; vertical-align: top;">
            <div>Smaller reporting company &#9744;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2.53%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 17.97%; vertical-align: top;">&#160;</td>
          <td style="width: 2.53%; vertical-align: top;">&#160;</td>
          <td style="width: 23.98%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2.53%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 23.98%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2.53%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 23.95%; vertical-align: top;">
            <div>Emerging Growth Company &#9744;</div>
          </td>
          <td style="width: 2.53%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. &#9744;
      <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">&#160;PART I</div>
    <div>&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>
    <div>&#160;</div>
    <div>
      <table class="DSPFListTable" id="zae970234b10d40e393d13d5b1e352813" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="text-align: left;"><font style="font-weight: bold; color: #000000;">Item 1.<br>
                </font></div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;"><font style="color: #000000;"><font style="font-weight: bold;">Plan Information.</font></font></div>
              <div style="text-align: left;"><font style="color: #000000;"><font style="font-weight: bold;"> <br>
                  </font></font></div>
              <div style="text-align: left;">
                <div style="text-indent: 0px;">Not required to be filed as part of this Registration Statement pursuant to the Note to Part I of Form S-8.</div>
                <font style="color: #000000;"><font style="font-weight: bold;"> </font></font></div>
            </td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div>
      <table class="DSPFListTable" id="z6a25a8ac16ff4330abcdb4b87cb968d7" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="text-align: left;"><font style="font-weight: bold; color: #000000;">Item 2.<br>
                </font></div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;"><font style="color: #000000; font-weight: bold;">Registrant Information and Employee Plan Annual Information.</font></div>
              <div style="text-align: left;"><font style="color: #000000; font-weight: bold;"> <br>
                </font></div>
              <div style="text-align: left;">
                <div style="text-indent: 0px;">Not required to be filed as part of this Registration Statement pursuant to the Note to Part I of Form S-8.</div>
                <font style="color: #000000; font-weight: bold;"> </font></div>
            </td>
          </tr>

      </table>
    </div>
    <div>&#160;<br>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">&#160;PART II</div>
    <div>&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div>&#160;</div>
    <div>
      <table class="DSPFListTable" id="z546a5d8b59444262a0647431d31f729a" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="text-align: left;"><font style="font-weight: bold; color: #000000;">Item 3.<br>
                </font></div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;"><font style="color: #000000; font-weight: bold;">Incorporation of Documents by Reference.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">The following documents, which have previously been filed by the Registrant with the Securities and Exchange Commission (the &#8220;Commission&#8221;), are incorporated by reference herein and shall be deemed to be a part hereof:</div>
    <div>&#160;</div>
    <div>
      <div>
        <div style="text-indent: 18pt;"><font style="text-indent: 18pt;">(1) </font>The Registrant<font style="color: #000000;">&#8217;</font>s <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001104506/000110450623000009/insm-20221231.htm">Annual
            Report on Form 10-K for the year ended December 31, 2022</a>, filed with the Commission on February 23, 2023;</div>
      </div>
    </div>
    <div><br>
    </div>
    <div>
      <div>
        <div style="text-indent: 18pt;"><font style="text-indent: 18pt;">(2) </font>The Registrant&#8217;s <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001104506/000110450623000012/insm-20230331.htm">Quarterly Report on Form 10-Q for the quarter
            ended March 31, 2023</a>, filed with the Commission on May 4, 2023;</div>
      </div>
    </div>
    <div><br>
    </div>
    <div>
      <div>
        <div style="text-indent: 18pt;"><font style="text-indent: 18pt;">(3) </font>The Registrant&#8217;s Current Report on Form 8-K, filed with the Commission on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001104506/000114036123024132/brhc20052827_8k.htm">May 11, 2023</a>; and</div>
      </div>
    </div>
    <div><br>
    </div>
    <div>
      <div>
        <div style="text-indent: 18pt;"><font style="text-indent: 18pt;">(4) </font><a href="https://www.sec.gov/Archives/edgar/data/1104506/000091664100000789/0000916641-00-000789-0001.txt">Description of the Registrant&#8217;s common stock contained in its
            registration statement on Form 8-A, dated June 1, 2000</a>, as updated by the Description of Securities Registered Under Section 12 of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), filed as <a href="https://www.sec.gov/Archives/edgar/data/1104506/000110450621000005/insm20201231ex45.htm">Exhibit 4.5 to the Registrant&#8217;s Annual Report on Form 10-K for the year ended December 31, 2020</a>, and including any amendment or report
          subsequently filed for the purpose of updating such description.</div>
      </div>
    </div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">In addition, subsequent to the date of this Registration Statement and prior to the filing of a post-effective amendment hereto that indicates all securities offered hereunder have been sold or deregisters all securities
      then remaining unsold, all reports and other documents filed by the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act shall be deemed to be incorporated by reference herein and to be a part hereof from the date of filing of
      such documents; <font style="font-style: italic;">provided, however</font>, that no information furnished (but not filed) under Item 2.02 or Item 7.01 of any Current Report on Form 8-K shall be incorporated by reference except to the extent
      specified in such Current Report on Form 8-K.</div>
    <div>&#160;</div>
    <div style="text-indent: 38.25pt;">For purposes of this Registration Statement, any statement contained in a document incorporated or deemed to be incorporated herein by reference shall be deemed to be modified or superseded to the extent that a
      statement contained herein or in any subsequently filed document that also is incorporated or is deemed to be incorporated herein by reference modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except
      as so modified or superseded, to constitute a part of this Registration Statement.</div>
    <div>&#160;</div>
    <div>
      <table class="DSPFListTable" id="z1b7d70abf0c2444b9f32d2c81239ca53" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="text-align: left;"><font style="font-weight: bold; color: #000000;">Item 4.<br>
                </font></div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;"><font style="color: #000000; font-weight: bold;">Description of Securities.</font></div>
              <div style="text-align: left;"><font style="color: #000000; font-weight: bold;"> <br>
                </font></div>
              <div style="text-align: left;">
                <div style="text-indent: 0px;">Not applicable.</div>
                <font style="color: #000000; font-weight: bold;"> </font></div>
            </td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div>
      <table class="DSPFListTable" id="z0d5e46792d804cad96c18233857736dc" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="text-align: left;"><font style="font-weight: bold; color: #000000;">Item 5.<br>
                </font></div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;"><font style="color: #000000; font-weight: bold;">Interests of Named Experts and Counsel.</font></div>
              <div style="text-align: left;"><font style="color: #000000; font-weight: bold;"> <br>
                </font></div>
              <div style="text-align: left;">
                <div style="text-indent: 0px;">Not applicable.</div>
                <font style="color: #000000; font-weight: bold;"> </font></div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-indent: 36pt;">&#160;<br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
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    <div>
      <table class="DSPFListTable" id="za5d4dc68ffd544e6b3c9c249864c4102" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="text-align: left;"><font style="font-weight: bold; color: #000000;">Item 6.<br>
                </font></div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;"><font style="color: #000000; font-weight: bold;">Indemnification of Directors and Officers.</font></div>
            </td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">The Virginia Stock Corporation Act (the &#8220;VSCA&#8221;) permits, and the Registrant&#8217;s Articles of Incorporation require, indemnification of the Registrant&#8217;s directors and officers in a variety of circumstances, which may include
      indemnification for liabilities under the Securities Act. Under the VSCA, a Virginia corporation is generally authorized to indemnify its directors and officers in civil or criminal actions if they acted in good faith and believed their conduct to be
      in the best interests of the corporation and, in the case of criminal actions, had no reasonable cause to believe that the conduct was unlawful, or if they engaged in conduct for which broader indemnification has been made permissible or obligatory
      by the Registrant. The VSCA requires such indemnification, unless limited by a corporation&#8217;s articles of incorporation, when a director or officer entirely prevails in the defense of any proceeding to which he or she was a party because he or she is
      or was a director or officer of the corporation. The VSCA provides that a corporation may make any other or further indemnity (including indemnity with respect to a proceeding by or in the right of the corporation), and may make additional provision
      for advances and reimbursement of expenses, if authorized by its articles of incorporation or shareholder-adopted bylaw or resolution, except an indemnity against willful misconduct or a knowing violation of the criminal law. The Registrant&#8217;s
      Articles of Incorporation require indemnification of directors and officers with respect to certain liabilities, expenses and other amounts imposed upon them because of having been a director or officer, except in the case of willful misconduct or a
      knowing violation of criminal law.</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">The VSCA establishes a statutory limit on liability of directors and officers of a corporation for damages assessed against them in a suit brought by or in the right of the corporation or brought by or on behalf of the
      corporation&#8217;s shareholders and authorizes a corporation to specify a lower monetary limit on liability (including the elimination of liability for monetary damages) in the corporation&#8217;s articles of incorporation or shareholder-approved bylaws;
      however, the liability of a director or officer shall not be limited if such director or officer engaged in willful misconduct or a knowing violation of the criminal law or of any federal or state securities law, including, without limitation, any
      unlawful insider trading or manipulation of the market for any security. As permitted by the VSCA, the Registrant&#8217;s Articles of Incorporation provide that no director or officer of the Registrant shall be liable to the Registrant or the Registrant&#8217;s
      shareholders for monetary damages with respect to any transaction, occurrence or course of conduct, except for liability resulting from such person&#8217;s having engaged in willful misconduct or a knowing violation of the criminal law or any federal or
      state securities law.</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">Certain directors and officers have been granted contractual indemnification rights under separate indemnification agreements with the Registrant, pursuant to which they will be entitled to indemnification from the
      Registrant under certain circumstances. Additionally, the employment agreements the Registrant has entered into with its executive officers provide for indemnification to the fullest extent permitted by law from and against any and all claims,
      damages, expenses (including attorneys&#8217; fees), judgments, penalties, fines, settlements, and all other liabilities incurred or paid by the executive officer in connection with the investigation, defense, prosecution, settlement or appeal of any
      threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative in nature, and to which the executive officer was or is a party or is threatened to be made a party by reason of the fact that he or
      she is or was an officer, employee or agent of the Registrant, or by reason of anything done or not done by him or her in any such capacity or capacities, provided that such executive officer acted in good faith, in a manner that was not grossly
      negligent or that constituted willful misconduct and in a manner he or she reasonably believed to be in or not opposed to the Registrant&#8217;s best interests, and, with respect to any criminal action or proceeding, had no reasonable cause to believe his
      or her conduct was unlawful. The Registrant also carries insurance on behalf of directors, officers, employees or agents that may cover liabilities under the Securities Act.</div>
    <div>&#160;</div>
    <div>
      <table class="DSPFListTable" id="z9a43fd105076432e8f976ad448f48126" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="text-align: left; text-indent: 2.25pt;"><font style="font-weight: bold; color: #000000;">Item 7.<br>
                </font></div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left; text-indent: 0px;"><font style="color: #000000;"><font style="font-family: 'Times New Roman', serif; font-size: 3pt;">&#160;</font><font style="font-weight: bold;">Exemption From Registration Claimed.</font></font></div>
              <div style="text-align: left; text-indent: 0px;"><font style="color: #000000;"><font style="font-weight: bold;"> <br>
                  </font></font></div>
              <div style="text-align: left; text-indent: 0px;">Not applicable.<font style="color: #000000;"><font style="font-weight: bold;"> </font></font></div>
            </td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div>
      <table class="DSPFListTable" id="zc78164bd0fe843e685e0c157f2d09af9" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="text-align: left;"><font style="font-weight: bold; color: #000000;">Item 8.<br>
                </font></div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left;"><font style="color: #000000;"><font style="font-family: 'Times New Roman', serif; font-size: 3pt;">&#160;</font><font style="font-weight: bold;">Exhibits.</font></font></div>
              <div style="text-align: left;"><font style="color: #000000;"><font style="font-weight: bold;"> <br>
                  </font></font></div>
              <div style="text-align: left;">A list of exhibits included in this Registration Statement is set forth on the Exhibit Index and is incorporated herein by reference.<font style="color: #000000;"><font style="font-weight: bold;"> </font></font></div>
            </td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
    </div>
    <div>
      <table class="DSPFListTable" id="ze6c92cbddcf84868a9e149ca722c9503" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 36pt;">
              <div style="margin: 0px 0px 0px 0px; color: #000000; text-align: left; text-indent: 0px;"><font style="font-weight: bold;">Item 9.</font> <br>
              </div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;"><font style="font-weight: bold;">Undertakings.</font></td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div>(a)<font style="color: #000000;">&#160;</font>The undersigned Registrant hereby undertakes:</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">(1)<font style="color: #000000;">&#160;</font>To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</div>
    <div>&#160;</div>
    <div style="text-indent: 72pt;">(i)<font style="color: #000000;">&#160;</font>To include any prospectus required by Section 10(a)(3) of the Securities Act;</div>
    <div>&#160;</div>
    <div style="text-indent: 72pt;">(ii)<font style="color: #000000;">&#160;</font>To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which,
      individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
      securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
      aggregate, the changes in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the <font style="color: #000000;">&#8220;</font>Calculation of Registration Fee<font style="color: #000000;">&#8221;</font>
      table in the effective registration statement; and</div>
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    <div style="text-indent: 72pt;">(iii)<font style="color: #000000;">&#160;</font>To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in
      the Registration Statement;&#160;</div>
    <div><font style="font-style: italic; color: #000000;"> </font><br>
    </div>
    <div><font style="font-style: italic; color: #000000;">provided, however</font><font style="color: #000000;">,</font> that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by
      those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement;</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">(2)<font style="color: #000000;">&#160;</font>That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the
      securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic; color: #000000;">bona fide</font> offering thereof; and</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">(3)<font style="color: #000000;">&#160;</font>To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
    <div>&#160;</div>
    <div>(b)<font style="color: #000000;">&#160;</font>The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant<font style="color: #000000;">&#8217;</font>s annual report
      pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan<font style="color: #000000;">&#8217;</font>s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by
      reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic; color: #000000;">bona fide</font> offering thereof.</div>
    <div>&#160;</div>
    <div>(c)<font style="color: #000000;">&#160;</font>Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or
      otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against
      such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer
      or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
      whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">EXHIBIT INDEX</div>
    <div>&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z605651c186ba4655b706cbe1ccf20568" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: #000000; font-size: 8pt; font-weight: bold;">Exhibit No.</div>
            <div style="color: #000000; font-size: 8pt; font-weight: bold;"> <br>
            </div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt; font-weight: bold;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 90%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: #000000; font-size: 8pt; font-weight: bold;">Exhibit Description</div>
            <div style="text-align: center; color: #000000; font-size: 8pt; font-weight: bold;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;"><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001104506/000114036123015322/ny20006571x1_def14a.htm#a021">4.1</a></div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div>Insmed Incorporated Amended and Restated 2019 Incentive Plan (incorporated by reference from Appendix A to Insmed Incorporated&#8217;s Proxy Statement on Schedule 14A, filed on March 31, 2023).<font style="color: #000000;">&#160;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;"><a href="https://www.sec.gov/Archives/edgar/data/1104506/000110450623000012/insm-20230331ex101.htm">4.2</a></div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div>Form of Insmed Incorporated Non-Qualified Stock Option Inducement Award Agreement (incorporated by reference from Exhibit 10.1 to Insmed Incorporated&#8217;s Quarterly Report on Form 10-Q, filed on May 4, 2023).</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td rowspan="1" style="width: 90%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;"><a href="https://www.sec.gov/Archives/edgar/data/1104506/000110450623000012/insm-20230321ex102.htm">4.3</a></div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">Form of Insmed Incorporated Non-Qualified Stock Option Inducement Award Agreement for non-U.S. employees (incorporated by reference from Exhibit 10.2 to Insmed Incorporated&#8217;s Quarterly Report on Form
            10-Q, filed on May 4, 2023).</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div><a href="ny20009120x2_ex5-1.htm">5.1*</a></div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div>Opinion of Hunton Andrews Kurth LLP.</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div><a href="ny20009120x2_ex5-1.htm">23.1*</a></div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div>Consent of Hunton Andrews Kurth LLP (included in Exhibit 5.1).</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div><a href="ny20009120x2_ex23-2.htm">23.2</a>*</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div>Consent of Ernst &amp; Young LLP, Independent Registered Public Accounting Firm.</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div><a href="#POWEROFATTORNEY">24.1</a></div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div>Power of Attorney (included on signature page hereto).</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top;">
            <div><a href="ny20009120x2_ex107.htm">107</a>*</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">
            <div>Filing Fee Table.</div>
          </td>
        </tr>

    </table>
    <div>&#160; <br>
      <hr style="background-color: #000000; border: 0px; height: 1px; width: 2in; margin-left: 0pt; margin-right: auto; color: #000000;" align="left" noshade="noshade"></div>
    <div>* Filed herewith.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURES</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration
      Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Bridgewater, State of New Jersey, on May 19, 2023.</div>
    <div style="text-align: center;">&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z9b2ce656204944218abf21c3e8e692c2" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 49.94%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td colspan="2" style="width: 50.06%; vertical-align: top;">
            <div style="color: #000000; font-weight: bold;">INSMED INCORPORATED</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.94%; vertical-align: top;">
            <div>&#160;</div>
          </td>
          <td style="width: 5.03%; vertical-align: top;"><br>
          </td>
          <td style="width: 45.03%; vertical-align: top;"><br>
          </td>
        </tr>
        <tr>
          <td style="width: 49.94%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 5.03%; vertical-align: top;">
            <div>By:</div>
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          <td style="width: 45.03%; vertical-align: top; border-bottom: #000000 2px solid;">/s/ William H. Lewis <br>
          </td>
        </tr>
        <tr>
          <td style="width: 49.94%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 5.03%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 45.03%; vertical-align: top;">
            <div>William H. Lewis</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.94%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 5.03%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 45.03%; vertical-align: top;">
            <div>Chairman, President and Chief Executive Officer</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: center; color: #000000; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Michael A. Smith his or her true and lawful attorney with power of substitution and resubstitution to sign in
      his or her name, place and stead in any and all such capacities the Registration Statement and any and all amendments and supplements thereto (including post-effective amendments) and documents in connection therewith, and to file the same with the
      Commission, said attorney to have full power and authority to do and perform, in the name of and on behalf of each of said officers and directors of the Registrant who shall have executed such a power of attorney, every act whatsoever which such
      attorney may deem necessary or desirable to be done in connection therewith, as fully and to all intents and purposes as such officer or director of the Registrant might or could do in person.</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</div>
    <div>&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zef478f2e87514072a175ae7d10aef6b6" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 28%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000; font-size: 8pt; font-weight: bold;">Signature</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt; font-weight: bold;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 50%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000; font-size: 8pt; font-weight: bold;">Title</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt; font-weight: bold;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 18%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000; font-size: 8pt; font-weight: bold;">Date</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 28%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 18%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 28%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 18%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 28%; vertical-align: top; border-bottom: #000000 2px solid;">/s/ William H. Lewis <br>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div>President and Chief Executive Officer; Chairman of the Board of Directors</div>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">&#160;May 19, 2023<font style="color: #000000;">&#160;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 28%; vertical-align: top;">
            <div>William H. Lewis</div>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div>(<font style="font-style: italic; color: #000000;">Principal Executive Officer</font>)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 28%; vertical-align: top;"> <br>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div>&#160;</div>
          </td>
          <td style="width: 50%; vertical-align: top;"> <br>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
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          <td style="width: 28%; vertical-align: top; border-bottom: #000000 2px solid;">/s/ Sara Bonstein <br>
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            <div style="text-align: center;">May 19, 2023</div>
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          <td style="width: 18%; vertical-align: top;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">May 19, 2023</div>
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        <tr>
          <td style="width: 28%; vertical-align: top;">
            <div>Alfred F. Altomari</div>
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            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
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          <td style="width: 28%; vertical-align: top;">
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          <td style="width: 2%; vertical-align: top;">
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          <td style="width: 50%; vertical-align: top;">
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            <div style="color: #000000;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
            <div>&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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        <tr>
          <td style="width: 28%; vertical-align: top; border-bottom: #000000 2px solid;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">May 19, 2023</div>
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          <td style="width: 28%; vertical-align: top;">
            <div>Elizabeth McKee Anderson</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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        <tr>
          <td style="width: 28%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
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            <div style="color: #000000;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
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            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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        <tr>
          <td style="width: 28%; vertical-align: top; border-bottom: #000000 2px solid;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
            <div>Director<font style="color: #000000;">&#160;</font></div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">May 19, 2023</div>
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        </tr>
        <tr>
          <td style="width: 28%; vertical-align: top;">
            <div>David R. Brennan</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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        <tr>
          <td style="width: 28%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 18%; vertical-align: top;">&#160;</td>
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          <td rowspan="1" style="width: 28%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 18%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 28%; vertical-align: top; border-bottom: #000000 2px solid;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
            <div>Director<font style="color: #000000;">&#160;</font></div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">May 19, 2023</div>
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        <tr>
          <td style="width: 28%; vertical-align: top;">
            <div>Clarissa Desjardins, Ph.D.</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 18%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
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        <tr>
          <td style="width: 28%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 28%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000; font-variant: small-caps;">*</div>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
            <div>Director<font style="color: #000000;">&#160;</font></div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">May 19, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 28%; vertical-align: top;">
            <div>Leo Lee</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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        <tr>
          <td rowspan="1" style="width: 28%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 18%; vertical-align: top;">&#160;</td>
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          <td rowspan="1" style="width: 28%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 18%; vertical-align: top;">&#160;</td>
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          <td style="width: 28%; vertical-align: top; border-bottom: #000000 2px solid;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">May 19, 2023</div>
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        <tr>
          <td style="width: 28%; vertical-align: top;">
            <div>David W.J. McGirr</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
          </td>
          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center; color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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        <tr>
          <td style="width: 28%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 18%; vertical-align: top;">&#160;</td>
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        <tr>
          <td rowspan="1" style="width: 28%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 18%; vertical-align: top;">&#160;</td>
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          <td style="width: 28%; vertical-align: top; border-bottom: #000000 2px solid;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">&#160;May 19, 2023</div>
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          <td style="width: 28%; vertical-align: top;">
            <div>Carol A. Schafer</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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        <tr>
          <td style="width: 28%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
            <div>&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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        <tr>
          <td style="width: 28%; vertical-align: top; border-bottom: #000000 2px solid;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="text-align: center;">&#160;May 19, 2023</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
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          <td style="width: 2%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
            <div style="color: #000000;">&#160;</div>
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          <td style="width: 18%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
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          <td rowspan="1" style="width: 24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Michael A. Smith<br>
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{"company-data": {"conformed-name": "INSMED Inc", "cik": "0001104506", "assigned-sic": "2834", "irs-number": "541972729", "state-of-incorporation": "VA", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-272091", "film-number": "23940427"}, "business-address": {"street1": "700 US HIGHWAY 202/206", "city": "BRIDGEWATER", "state": "NJ", "zip": "08807", "phone": "908-977-9900"}, "mail-address": {"street1": "700 US HIGHWAY 202/206", "city": "BRIDGEWATER", "state": "NJ", "zip": "08807"}, "former-company": {"former-conformed-name": "INSMED INC", "date-changed": "20000128"}}
As filed with the Securities and Exchange Commission
      on May 19, 2023
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
INSMED INCORPORATED
(Exact name of registrant as specified in its charter)
Virginia
54-1972729
(State or other jurisdiction of incorporation or
organization)
(I.R.S. Employer Identification No.)
700 US Highway 202/206
Bridgewater, New Jersey 08807
(Address of Principal Executive Offices including zip code)
Insmed Incorporated Amended and Restated 2019 Incentive Plan
Insmed Incorporated Non-Qualified Stock Option Inducement Awards
(Full title of the plans)
Michael A. Smith, Esq.
Insmed Incorporated
General Counsel, Senior Vice President
700 US Highway 202/206
Bridgewater, New Jersey 08807
(908) 977-9900
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies of all communications, including all communications sent to the agent for service, should be sent to:
Michael J. Riella, Esq.
Covington & Burling LLP
One CityCenter
850 Tenth St. NW
Washington, DC 20001
(202) 662-6000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See definitions of "large accelerated filer," "accelerated
      filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act:
Large accelerated filer ☒
Accelerated filer ☐
Non-accelerated filer ☐
Smaller reporting company ☐
Emerging Growth Company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. ☐
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Item 1.
Plan Information.
Not required to be filed as part of this Registration Statement pursuant to the Note to Part I of Form S-8.
Item 2.
Registrant Information and Employee Plan Annual Information.
Not required to be filed as part of this Registration Statement pursuant to the Note to Part I of Form S-8.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The following documents, which have previously been filed by the Registrant with the Securities and Exchange Commission (the "Commission"), are incorporated by reference herein and shall be deemed to be a part hereof:
(1)
The Registrant
'
s
Annual
            Report on Form 10-K for the year ended December 31, 2022
, filed with the Commission on February 23, 2023;
(2)
The Registrant's
Quarterly Report on Form 10-Q for the quarter
            ended March 31, 2023
, filed with the Commission on May 4, 2023;
(3)
The Registrant's Current Report on Form 8-K, filed with the Commission on
May 11, 2023
; and
(4)
Description of the Registrant's common stock contained in its
            registration statement on Form 8-A, dated June 1, 2000
, as updated by the Description of Securities Registered Under Section 12 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), filed as
Exhibit 4.5 to the Registrant's Annual Report on Form 10-K for the year ended December 31, 2020
, and including any amendment or report
          subsequently filed for the purpose of updating such description.
In addition, subsequent to the date of this Registration Statement and prior to the filing of a post-effective amendment hereto that indicates all securities offered hereunder have been sold or deregisters all securities
      then remaining unsold, all reports and other documents filed by the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act shall be deemed to be incorporated by reference herein and to be a part hereof from the date of filing of
      such documents;
provided, however
, that no information furnished (but not filed) under Item 2.02 or Item 7.01 of any Current Report on Form 8-K shall be incorporated by reference except to the extent
      specified in such Current Report on Form 8-K.
For purposes of this Registration Statement, any statement contained in a document incorporated or deemed to be incorporated herein by reference shall be deemed to be modified or superseded to the extent that a
      statement contained herein or in any subsequently filed document that also is incorporated or is deemed to be incorporated herein by reference modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except
      as so modified or superseded, to constitute a part of this Registration Statement.
Item 4.
Description of Securities.
Not applicable.
Item 5.
Interests of Named Experts and Counsel.
Not applicable.
Item 6.
Indemnification of Directors and Officers.
The Virginia Stock Corporation Act (the "VSCA") permits, and the Registrant's Articles of Incorporation require, indemnification of the Registrant's directors and officers in a variety of circumstances, which may include
      indemnification for liabilities under the Securities Act. Under the VSCA, a Virginia corporation is generally authorized to indemnify its directors and officers in civil or criminal actions if they acted in good faith and believed their conduct to be
      in the best interests of the corporation and, in the case of criminal actions, had no reasonable cause to believe that the conduct was unlawful, or if they engaged in conduct for which broader indemnification has been made permissible or obligatory
      by the Registrant. The VSCA requires such indemnification, unless limited by a corporation's articles of incorporation, when a director or officer entirely prevails in the defense of any proceeding to which he or she was a party because he or she is
      or was a director or officer of the corporation. The VSCA provides that a corporation may make any other or further indemnity (including indemnity with respect to a proceeding by or in the right of the corporation), and may make additional provision
      for advances and reimbursement of expenses, if authorized by its articles of incorporation or shareholder-adopted bylaw or resolution, except an indemnity against willful misconduct or a knowing violation of the criminal law. The Registrant's
      Articles of Incorporation require indemnification of directors and officers with respect to certain liabilities, expenses and other amounts imposed upon them because of having been a director or officer, except in the case of willful misconduct or a
      knowing violation of criminal law.
The VSCA establishes a statutory limit on liability of directors and officers of a corporation for damages assessed against them in a suit brought by or in the right of the corporation or brought by or on behalf of the
      corporation's shareholders and authorizes a corporation to specify a lower monetary limit on liability (including the elimination of liability for monetary damages) in the corporation's articles of incorporation or shareholder-approved bylaws;
      however, the liability of a director or officer shall not be limited if such director or officer engaged in willful misconduct or a knowing violation of the criminal law or of any federal or state securities law, including, without limitation, any
      unlawful insider trading or manipulation of the market for any security. As permitted by the VSCA, the Registrant's Articles of Incorporation provide that no director or officer of the Registrant shall be liable to the Registrant or the Registrant's
      shareholders for monetary damages with respect to any transaction, occurrence or course of conduct, except for liability resulting from such person's having engaged in willful misconduct or a knowing violation of the criminal law or any federal or
      state securities law.
Certain directors and officers have been granted contractual indemnification rights under separate indemnification agreements with the Registrant, pursuant to which they will be entitled to indemnification from the
      Registrant under certain circumstances. Additionally, the employment agreements the Registrant has entered into with its executive officers provide for indemnification to the fullest extent permitted by law from and against any and all claims,
      damages, expenses (including attorneys' fees), judgments, penalties, fines, settlements, and all other liabilities incurred or paid by the executive officer in connection with the investigation, defense, prosecution, settlement or appeal of any
      threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative in nature, and to which the executive officer was or is a party or is threatened to be made a party by reason of the fact that he or
      she is or was an officer, employee or agent of the Registrant, or by reason of anything done or not done by him or her in any such capacity or capacities, provided that such executive officer acted in good faith, in a manner that was not grossly
      negligent or that constituted willful misconduct and in a manner he or she reasonably believed to be in or not opposed to the Registrant's best interests, and, with respect to any criminal action or proceeding, had no reasonable cause to believe his
      or her conduct was unlawful. The Registrant also carries insurance on behalf of directors, officers, employees or agents that may cover liabilities under the Securities Act.
Item 7.
Exemption From Registration Claimed.
Not applicable.
Item 8.
Exhibits.
A list of exhibits included in this Registration Statement is set forth on the Exhibit Index and is incorporated herein by reference.
Item 9.
Undertakings.
(a)
The undersigned Registrant hereby undertakes:
(1)
To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)
To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which,
      individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
      securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the
      aggregate, the changes in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the
"
Calculation of Registration Fee
"
table in the effective registration statement; and
(iii)
To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in
      the Registration Statement;
provided, however
,
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by
      those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement;
(2)
That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the
      securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof; and
(3)
To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)
The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant
'
s annual report
      pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan
'
s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by
      reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(c)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or
      otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against
      such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer
      or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
      whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
EXHIBIT INDEX
Exhibit No.
Exhibit Description
4.1
Insmed Incorporated Amended and Restated 2019 Incentive Plan (incorporated by reference from Appendix A to Insmed Incorporated's Proxy Statement on Schedule 14A, filed on March 31, 2023).
4.2
Form of Insmed Incorporated Non-Qualified Stock Option Inducement Award Agreement (incorporated by reference from Exhibit 10.1 to Insmed Incorporated's Quarterly Report on Form 10-Q, filed on May 4, 2023).
4.3
Form of Insmed Incorporated Non-Qualified Stock Option Inducement Award Agreement for non-U.S. employees (incorporated by reference from Exhibit 10.2 to Insmed Incorporated's Quarterly Report on Form
            10-Q, filed on May 4, 2023).
5.1*
Opinion of Hunton Andrews Kurth LLP.
23.1*
Consent of Hunton Andrews Kurth LLP (included in Exhibit 5.1).
23.2
*
Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm.
24.1
Power of Attorney (included on signature page hereto).
107
*
Filing Fee Table.
* Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration
      Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Bridgewater, State of New Jersey, on May 19, 2023.
INSMED INCORPORATED
By:
/s/ William H. Lewis
William H. Lewis
Chairman, President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Michael A. Smith his or her true and lawful attorney with power of substitution and resubstitution to sign in
      his or her name, place and stead in any and all such capacities the Registration Statement and any and all amendments and supplements thereto (including post-effective amendments) and documents in connection therewith, and to file the same with the
      Commission, said attorney to have full power and authority to do and perform, in the name of and on behalf of each of said officers and directors of the Registrant who shall have executed such a power of attorney, every act whatsoever which such
      attorney may deem necessary or desirable to be done in connection therewith, as fully and to all intents and purposes as such officer or director of the Registrant might or could do in person.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ William H. Lewis
President and Chief Executive Officer; Chairman of the Board of Directors
May 19, 2023
William H. Lewis
(
Principal Executive Officer
)
/s/ Sara Bonstein
Chief Financial Officer
May 19, 2023
Sara Bonstein
(
Principal Financial Officer, Principal Accounting Officer
)
*
Director
May 19, 2023
Alfred F. Altomari
*
Director
May 19, 2023
Elizabeth McKee Anderson
*
Director
May 19, 2023
David R. Brennan
*
Director
May 19, 2023
Clarissa Desjardins, Ph.D.
*
Director
May 19, 2023
Leo Lee
*
Director
May 19, 2023
David W.J. McGirr
*
Director
May 19, 2023
Carol A. Schafer
*
Director
May 19, 2023
Melvin Sharoky, M.D.
* By:
/s/ Michael A. Smith
Michael A. Smith
Attorney-in-Fact