<html>
<head>
<title> Form S-8 </title>
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<p><table width=600><tr>
    <td  align=center><font size=2>As filed with the Securities and Exchange Commission
      on March 21, 2003</font></td>
  </tr></table>

<table width=600><tr><td align=right><font size=2>Registration No. 333-</font></td></tr></table>

<p><table width=600><tr><td  align=center><font size=2><B>SECURITIES AND EXCHANGE
COMMISSION  <BR>Washington, D.C. 20549</B></font></td></tr></table>


<p><table width=600><tr><td  align=center><FONT SIZE="5"><B>Form S-8</B></FONT></td></tr></table>

<p><table width=600><tr><td  align=center><font size=2><B>REGISTRATION STATEMENT<BR>  UNDER<BR>
THE SECURITIES ACT OF 1933</B></font></td></tr></table>


<p><table width=600><tr>
    <td  align=center><font size=4><B><font size="5">The Immune Response Corporation</font><br>
      </B></font><font size="1">(Exact name of registrant as specified in its
      charter)</font></td>
  </tr></table>

<p>
<table width=600>
  <tr>
    <td align=center valign="top" width="278"><font size="2"><b>Delaware</b></font>
      <hr noshade size="1">
      <font size="1">(State or other jurisdiction of<br>
      incorporation or organization) </font></td>
    <td align=center valign="top" width="45">&nbsp;</td>
    <td align=center valign="top" width="261"><font size="2"><b>33-0225679</b></font>
      <hr noshade size="1">
      <font size="1">(I.R.S. Employer Identification No.)</font></td>
  </tr>
</table>
<br>
<table width=600>
  <tr>
    <td align=center width="269"><font size="2"><b>5931 Darwin Court <br>
      Carlsbad, California</b></font>
      <hr noshade size="1">
      <font size="1">(Address of Principal Executive
      Offices)</font> </td>
    <td align=center width="54">&nbsp;</td>
    <td align=center width="261"><font size="2"><b>92008</b></font>
      <hr noshade size="1">
      <font size="1">(Zip
      Code)</font></td>
  </tr>
</table>
<p><table width=600><tr><td  align=center><FONT SIZE="2"><B><U>THE IMMUNE RESPONSE CORPORATION
2003 STOCK PLAN<BR> STOCK OPTION GRANT OUTSIDE OF A PLAN </U><BR> <FONT SIZE="1"></FONT></B><FONT SIZE="1">(Full title of the plans)</FONT></FONT></td></tr></table>


<br>
<table width=600>
  <tr valign="top">
    <td align=center width="269" valign="baseline" height="23">&nbsp;</td>
    <td align=center width="54" height="23">&nbsp;</td>
    <td align=center width="261" height="23"><font size="2">Copy to:</font></td>
  </tr>
  <tr valign="top">
    <td align=center width="269" valign="baseline"><font size="2">MICHAEL L. JEUB<br>
      Chief Financial Officer<br>
      5931 Darwin Court<br>
      Carlsbad, CA 92008<br>
      <u>(760) 431-7080</u><br>
      <font size="1">(Name, address and telephone number, <br>
      including area code, of agent for service)</font></font></td>
    <td align=center width="54">&nbsp;</td>
    <td align=center width="261"><font size="2">P. JOSEPH CAMPISI, JR.<br>
      Pillsbury Winthrop LLP <br>
      50 Fremont Street <br>
      San Francisco, CA 94120-7880<br>
      <u>(415) 983-1000</u></font></td>
  </tr>
</table>
<br>
<table width="600" border="0" cellpadding="0">
  <tr align="center">
    <td colspan="5"><font size="2"><b>CALCULATION OF REGISTRATION FEE</b></font>
      <hr size="1" noshade>
    </td>
  </tr>
  <tr align="center" valign="top">
    <td width="138"><font size="2"><b>Title of Securities to<br>
      be Registered</b></font></td>
    <td width="104"><font size="2"><b>Amount to be<br>
      Registered (2)</b></font></td>
    <td width="131"><font size="2"><b>Proposed <br>
      Maximum<br>
      Offering Price per<br>
      Share </b></font></td>
    <td width="127"><font size="2"><b>Proposed Maximum<br>
      Aggregate Offering <br>
      Price</b></font></td>
    <td width="88"><font size="2"><b>Amount of<br>
      Registration<br>
      Fee</b></font></td>
  </tr>
  <tr>
    <td colspan="5" align="center">
      <hr size="1" noshade>
    </td>
  </tr>
  <tr>
    <td width="138" align="center"><font size="2">Common Stock, par <br>
      value $0.0025 (3)</font></td>
    <td width="104" align="center" valign="top"><font size="2">3,250,000 shares</font></td>
    <td width="131" align="center" valign="top"><font size="2">$1.22(1)</font></td>
    <td width="127" align="center" valign="top"><font size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;$3,965,000(1)</font></td>
    <td width="88" align="center" valign="top"><font size="2"> $320.77</font></td>
  </tr>
  <tr>
    <td colspan="5" align="center">
      <hr size="1" noshade>
    </td>
  </tr>
  <tr>
    <td width="138" align="center"><font size="2">Common Stock, par <br>
      value $0.0025</font></td>
    <td width="104" align="center"><font size="2">750,000 shares</font></td>
    <td width="131" align="center"><font size="2">$1.20&nbsp;&nbsp;&nbsp;&nbsp;</font></td>
    <td width="127" align="center"><font size="2">$&nbsp;&nbsp;&nbsp;900,000</font></td>
    <td width="88" align="center"><font size="2">$&nbsp;&nbsp;72.81</font></td>
  </tr>
  <tr>
    <td colspan="5" align="center">
      <hr size="1" noshade>
    </td>
  </tr>
  <tr>
    <td width="138" align="center"><font size="2">Total</font></td>
    <td width="104" align="center"><font size="2">4,000,000 shares</font></td>
    <td width="131" align="center"><font size="2">&#151;</font></td>
    <td width="127" align="center"><font size="2">$4,865,000</font></td>
    <td width="88" align="center"><font size="2">$393.58</font></td>
  </tr>
  <tr>
    <td colspan="5" align="center">
      <hr size="1" noshade>
    </td>
  </tr>
</table>
<p><table width=600><tr>
    <td><font size=2>(1) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Estimated solely for the
      purpose of calculating the registration fee pursuant to Rule 457, based
      upon the average of the high and low prices as reported on the Nasdaq Stock
      Market on March 19, 2003.</font></td>
  </tr></table>

<table width=600><tr>
    <td><font size=2>(2)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In addition, pursuant to
      Rule 416(c) under the Securities Act of 1933, this registration statement
      also covers an indeterminate amount of interests to be offered or sold pursuant
      to the employee benefit plan described herein.</font></td>
  </tr></table>

<table width=600><tr>
    <td><font size=2>(3) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The shares as issuable
      pursuant to the respective plans as follows: Stock Option Grant Outside
      of a Plan, 750,000 shares and 2003 Stock Option Plan, 3,250,000 shares.</font></td>
  </tr></table>

<table width=600><tr><td><hr size=1 noshade align=left  width=75></td></tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
Registration Statement shall become effective upon filing in accordance with Rule 462
under the Securities  Act of 1933.</font></td></tr></table>

<p>&nbsp;<hr size=5 noshade width=600 align=LEFT><p>&nbsp;




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<p><table width=600><tr><td><FONT SIZE="2"><U>PART I</U></FONT> </td></tr></table>

<p><table width=600><tr><td><FONT SIZE="2"><U>INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS</U></FONT></td></tr></table><p></p>

<p><table width=600><tr>
    <td><FONT SIZE="2"><u>Item 1.</u>&nbsp;&nbsp;&nbsp;<u>Plan Information.</u>*</FONT></td>
  </tr></table>

<p><table width=600><tr>
    <td><FONT SIZE="2"><u>Item 2.</u>&nbsp;&nbsp;&nbsp;<u>Registrant Information
      and Employee Plan Annual Information.</u>*</FONT></td>
  </tr></table>

<p><table width=600><tr><td width=30>&nbsp;</td><td width=570><font size=2>* Information
required by Part I to be contained in the Section 10(a) prospectus is omitted from  this
Registration Statement in accordance with Rule 428 under the Securities act of 1933 and
the Note  to Part I of Form S-8.</font></td></tr></table>

<p><table width=600><tr><td><FONT SIZE="2"><U>PART II</U></FONT> </td></tr></table>

<p><table width=600><tr><td><FONT SIZE="2"><U>INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT</U></FONT></td></tr></table>

<p><table width=600><tr><td><FONT SIZE="2"><U>Item 3.</U> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Incorporation of Certain Documents by
Reference.</U></FONT></td></tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
following documents filed by Registrant with the Securities and Exchange Commission are
incorporated by  reference in this registration statement:</font></td></tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Registrant&#146;s Annual Report on Form 10-K, as restated (File No. 0-18006) for the
fiscal year ended  December&nbsp;31, 2001, which contains, among other things, the
consolidated financial statements of Registrant and certain  supplementary data for the
fiscal year ended December 31, 2001 together with the report therein of BDO Seidman, LLP,
the  Registrant&#146;s independent public accountants;</font></td></tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Registrant&#146;s Quarterly Report on Form 10-Q (File No. 0-18006) for the quarter ended
June 30, 2002;</font></td></tr></table>

<p><table width=600><tr>
    <td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)
      &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Registrant&#146;s Quarterly Report on Form
      10-Q (File No. 0-18006) for the quarter ended September 30, 2002, which
      contains, among other things, the condensed consolidated financial statements
      of the Registrant and certain supplementary data for the quarterly period
      ended September 30, 2002;</font></td>
  </tr></table>

<p><table width=600><tr>
    <td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4)
      &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The description of Registrant&#146;s Common
      Stock contained in Registrant&#146;s registration statement on Form&nbsp;8-A,
      filed March 30, 1990.</font></td>
  </tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In
addition, all documents subsequently filed by Registrant pursuant to Sections&nbsp;13(a),
13(c), 14 and 15(d) of  the Securities Exchange Act of 1934, prior to the filing of a
post-effective amendment which indicates that all  securities offered have been sold or
which deregisters all securities then remaining unsold, shall be deemed to be
incorporated by reference in this registration statement and to be a part hereof from the
date of filing of such  documents.</font></td></tr></table>

<p><table width=600><tr><td><FONT SIZE="2"><U>Item 4.</U> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Description of Securities.</U></FONT></td></tr></table>

<p><table width=600><tr>
    <td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not
      applicable.</font></td>
  </tr></table>

<p>&nbsp;<hr size=5 noshade width=600 align=LEFT><p>&nbsp;




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<p><table width=600><tr><td><FONT SIZE="2"><U>Item 5.</U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <U>Interests of Named Experts and Counsel.</U></FONT></td></tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Certain
legal matters with respect to the validity of  securities  offered  hereby has been
passed upon for us by  Pillsbury  Winthrop  LLP. A partner of  Pillsbury  Winthrop  LLP
owns 1,106 shares of common stock and an option to acquire  5,000 shares of our common
stock.</font></td></tr></table>


<p><table width=600><tr><td><FONT SIZE="2"><U>Item 6.</U> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<U>Indemnification of Directors and
Officers.</U></FONT></td></tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section
145 of the Delaware General Corporation Law, the &#147;Delaware GCL&#148;, permits our
board of directors to  indemnify any person against expenses (including attorneys&#146; fees),
judgments, fines and amounts paid in settlement  actually and reasonably incurred by him
in connection with any threatened, pending or completed action, suit or  proceeding in
which such person is made a party by reason of his being or having been a director,
officer, employee or  agent of ours, in terms sufficiently broad to permit such
indemnification under certain circumstances for liabilities  (including reimbursement for
expenses incurred) arising under the Securities Act of 1933, as amended. The Delaware GCL
provides that indemnification pursuant to its provisions is not exclusive of other rights
of indemnification to which a  person may be entitled under any by-law, agreement, vote
of stockholders or disinterested directors, or otherwise.</font></td></tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Article
VII of our Restated Certificate of Incorporation, as amended, and Article V of our
Bylaws, provide for  indemnification of our directors, officers, employees and other
agents to the maximum extent permitted by law. In  addition, we have entered into
separate indemnification agreements with our directors and officers that will require us,
among other things, to indemnify them against certain liabilities that may arise by
reason of their status or service as  directors or officers to the fullest extent not
prohibited by law.</font></td></tr></table>

<p><table width=600><tr><td><FONT SIZE="2"><U>Item 7.</U> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <U>Exemption from Registration Claimed.</U></FONT></td></tr></table>

<p><table width=600><tr>
    <td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not
      applicable.</font></td>
  </tr></table>

<p><table width=600><tr><td><FONT SIZE="2"><U>Item 8.</U> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <U>Exhibits.</U></FONT></td></tr></table>

<p><table width=600><tr>
    <td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;See
      Index to Exhibits.*</font></td>
  </tr></table>

<p><table width=600><tr><td><FONT SIZE="2"><U>Item 9.</U> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <U>Undertakings.</U></FONT></td></tr></table>

<P>
<table width=600>
  <TR>
    <TD width=9% valign=top>&nbsp;</TD>
    <TD width=6% valign=top><font size=2>(a) </FONT></TD>
    <TD width=85% valign=top><font size=2> The undersigned Registrant hereby undertakes:</font></TD>
  </TR>
</TABLE>

<p><table width=600>
<tr>
    <td width=50>&nbsp;</td>
    <td width=538><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)
      &nbsp;&nbsp;&nbsp;&nbsp;To file, during any period in which offers or sales
      are being made, a post-effective amendment to this registration statement:</font></td>
  </tr></table>

<p><table width=600>
<tr><td width=90>&nbsp;</td>
    <td width=510><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) &nbsp;&nbsp;&nbsp;&nbsp;To
      include any prospectus required by section&nbsp;10(a)(3) of the Securities
      Act of 1933;</font></td>
  </tr></table>

<p><table width=600>
<tr><td width=90>&nbsp;</td>
    <td width=510><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) &nbsp;&nbsp;&nbsp;&nbsp;To
      reflect in the prospectus any facts or events arising after the effective
      date of the registration statement (or the most recent post-effective amendment
      thereof) which, individually or in the aggregate, represent a fundamental
      change in the information set forth in the registration statement;</font></td>
  </tr></table>

<p>&nbsp;<hr size=5 noshade width=600 align=LEFT><p>&nbsp;


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<P>
<table width=600>
  <TR>
    <TD width=15% valign=top>&nbsp;</TD>
    <TD width=85% valign=top><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
      </FONT><font size=2> To include any material information with respect to
      the plan of distribution not previously disclosed in the registration statement
      or any material change to such information in the registration statement;</font></TD>
  </TR>
</TABLE>


<p><table width=600><tr><td width=60>&nbsp;</td><td width=540><font size=2>provided,
however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the registration
statement is on  Form&nbsp;S-3 or Form S-8, and the information required to be included
in a post-effective amendment by those  paragraphs is contained in periodic reports filed
by the Registrant pursuant to section&nbsp;13 or section&nbsp;15(d) of  the Securities
Exchange Act of 1934 that are incorporated by reference in the registration statement.</font></td></tr></table><p></P>

<p><table width=600>
<tr><td width=60>&nbsp;</td>
<td width=540><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)
That, for the purpose of determining any liability under the Securities Act of 1933, each
such post-effective  amendment shall be deemed to be a new registration statement
relating to the securities offered therein, and the  offering of such securities at that
time shall be deemed to be the initial bona fide offering thereof.</font></td></tr></table><p></P>

<p><table width=600>
<tr><td width=60>&nbsp;</td>
<td width=540><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)
To remove from registration by means of a post-effective amendment any of the securities
being registered which  remain unsold at the termination of the offering.</font></td></tr></table><p></P>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)
The undersigned Registrant hereby further undertakes that, for purposes of determining
any liability under the  Securities Act of 1933, each filing of the Registrant&#146;s
annual report pursuant to section&nbsp;13(a) or section 15(d) of the  Securities Exchange
Act of 1934 that is incorporated by reference in the registration statement shall be
deemed to be a  new registration statement relating to the securities offered therein,
and the offering of such securities at that time  shall be deemed to be the initial bona
fide offering thereof.</font></td></tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)
Insofar as indemnification for liabilities arising under the Securities Act of 1933 may
be permitted to  directors, officers and controlling persons of the Registrant pursuant
to the foregoing provisions, or otherwise, the  Registrant has been advised that in the
opinion of the Securities and Exchange Commission such indemnification is against  public
policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable.  In
the event that a claim for  indemnification against such liabilities (other than the
payment by the Registrant of expenses incurred or paid by a  director, officer or
controlling person of the Registrant in the successful defense of any action, suit or
proceeding) is  asserted by such director, officer or controlling person in connection
with the securities being registered, the  Registrant will, unless in the opinion of its
counsel the matter has been settled by controlling precedent, submit to a  court of
appropriate jurisdiction the question whether such indemnification by it is against
public policy as expressed  in the Securities Act of 1933 and will be governed by the
final adjudication of such issue.</font></td></tr></table>

<p>&nbsp;<hr size=5 noshade width=600 align=LEFT><p>&nbsp;





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<p><table width=600><tr><td><FONT SIZE="2"><U>SIGNATURES</U></FONT></td></tr></table>

<p><table width=600><tr>
    <td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
      to the requirements of the Securities Act of 1933, the Registrant certifies
      that it has reasonable grounds to believe that it meets all of the requirements
      for filing on Form&nbsp;S-8, and has duly caused this registration statement
      to be signed on its behalf by the undersigned, thereunto duly authorized,
      in the City of Carlsbad, State of California, on March 20, 2003.</font></td>
  </tr></table>

<p>
<table width=600>
  <tr>
    <td align=right width="247">&nbsp;</td>
    <td align=left width="341"><font size=2>THE IMMUNE RESPONSE CORPORATION <BR>
      <BR>
      <BR>
      By /s/ Michael L. Jeub </font>
      <hr size="1" noshade align="right" width="96%">
      <font size=2>Michael L. Jeub<BR>
      Chief Financial Officer and Vice President of Finance</font></td>
  </tr>
</table>

<BR>



<p><table width=600><tr><td><FONT SIZE="2"><U>POWER OF ATTORNEY</U></FONT></td></tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW
ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and
appoints Michael  L. Jeub and Dr. John N. Bonfiglio, and each of them his true and lawful
attorneys-in-fact and agents, each with full  power of substitution and resubstitution,
for him and in his name, place and stead, in any and all capacities, to sign  any and all
amendments, including post-effective amendments, to this registration statement, and to
file the same, with  exhibits thereto and other documents in connection therewith, with
the Securities and Exchange Commission, granting unto  said attorneys-in-fact and agents,
full power and authority to do and perform each and every act and thing requisite and
necessary to be done, as fully to all intents and purposes as he might or could do in
person, hereby ratifying and  confirming all that said attorneys-in-fact and agents, or
his substitute or substitutes, may do or cause to be done by  virtue hereof.</font></td></tr></table>

<p><table width=600><tr><td><font size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
to the requirements of the Securities Act of 1933, this registration statement has been
signed by the  following persons in the capacities and on the date indicated:</font></td></tr></table>


<p>
<table width="600" border="0" cellpadding="0">
  <tr>
    <td width="233"><font size="2"><u>Name</u></font></td>
    <td width="235"><font size="2"><u>Title</u></font></td>
    <td width="124"><font size="2"><u>Date</u></font></td>
  </tr>
  <tr>
    <td width="233">&nbsp;</td>
    <td width="235">&nbsp;</td>
    <td width="124">&nbsp;</td>
  </tr>
  <tr>
    <td width="233"><font size="2">/s/ John N. Bonfiglio </font>
      <hr noshade size="1" width="75%" align="left">
      <font size="2">John N. Bonfiglio</font></td>
    <td width="235" valign="top"><font size="2">Chief Executive Officer and Director
      </font></td>
    <td width="124" valign="middle"><font size="2">March 20, 2003</font></td>
  </tr>
  <tr>
    <td width="233">&nbsp;</td>
    <td width="235" valign="top">&nbsp;</td>
    <td width="124" valign="middle">&nbsp;</td>
  </tr>
  <tr valign="top">
    <td width="233"><font size="2">/s/ Michael L. Jeub</font>
      <hr noshade size="1" width="75%" align="left">
      <font size="2">Michael L. Jeub</font></td>
    <td width="235" valign="top"><font size="2">Chief Financial Officer and Vice
      <br>
      President of Finance</font></td>
    <td width="124" valign="middle"><font size="2">March 20, 2003 </font></td>
  </tr>
  <tr>
    <td width="233">&nbsp;</td>
    <td width="235">&nbsp;</td>
    <td width="124">&nbsp;</td>
  </tr>
</table>
<p>&nbsp;
<table width=600><tr><td width=60 align=left><font size=1>&nbsp;</font></td><td width=480 align=center><font size="2">
</font></td><td width=60 align=right><font size="1">&nbsp;</font></td></tr></table><p>&nbsp;<hr size=5 noshade width=600 align=LEFT>
<p>&nbsp;
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<p>
<table width="600" border="0" cellpadding="0">
  <tr>
    <td width="233"><font size="2"><u>Name</u></font></td>
    <td width="235"><font size="2"><u>Title</u></font></td>
    <td width="124"><font size="2"><u>Date</u></font></td>
  </tr>
  <tr>
    <td width="233">&nbsp;</td>
    <td width="235">&nbsp;</td>
    <td width="124">&nbsp;</td>
  </tr>
  <tr valign="top">
    <td width="233"><font size="2">/s/ James B. Glavin </font>
      <hr noshade size="1" width="75%" align="left">
      <font size="2">James B. Glavin</font></td>
    <td width="235"><font size="2">Chairman of the Board</font></td>
    <td width="124" valign="middle"><font size="2">March 20, 2003</font></td>
  </tr>
  <tr>
    <td width="233">&nbsp;</td>
    <td width="235">&nbsp;</td>
    <td width="124">&nbsp;</td>
  </tr>
  <tr valign="top">
    <td width="233"><font size="2">/s/ Kevin B. Kimberlin </font>
      <hr noshade size="1" width="75%" align="left">
      <font size="2">Kevin B. Kimberlin</font></td>
    <td width="235"><font size="2">Director</font></td>
    <td width="124" valign="middle"><font size="2">March 20, 2003 </font></td>
  </tr>
  <tr>
    <td width="233">&nbsp;</td>
    <td width="235">&nbsp;</td>
    <td width="124" valign="middle">&nbsp;</td>
  </tr>
  <tr>
    <td width="233"><font size="2">/s/ Jed B. Trosper </font>
      <hr noshade size="1" width="75%" align="left">
      <font size="2">Jed B. Trosper</font></td>
    <td width="235" valign="top"><font size="2">Director</font></td>
    <td width="124" valign="middle"><font size="2">March 20, 2003 </font></td>
  </tr>
  <tr>
    <td width="233">&nbsp;</td>
    <td width="235">&nbsp;</td>
    <td width="124" valign="middle">&nbsp;</td>
  </tr>
  <tr>
    <td width="233"><font size="2">/s/ Dennis J. Carlo</font>
      <hr noshade size="1" width="75%" align="left">
      <font size="2"> Dennis J. Carlo</font></td>
    <td width="235" valign="top"><font size="2">Director</font></td>
    <td width="124" valign="middle"><font size="2">March 20, 2003 </font></td>
  </tr>
  <tr>
    <td width="233">&nbsp;</td>
    <td width="235">&nbsp;</td>
    <td width="124" valign="middle">&nbsp;</td>
  </tr>
  <tr>
    <td width="233"><font size="2">/s/ William M. Sullivan</font>
      <hr noshade size="1" width="75%" align="left">
      <font size="2"> William M. Sullivan </font></td>
    <td width="235" valign="top"><font size="2">Director</font></td>
    <td width="124" valign="middle"><font size="2">March 20, 2003 </font></td>
  </tr>
  <tr>
    <td width="233">&nbsp;</td>
    <td width="235">&nbsp;</td>
    <td width="124">&nbsp;</td>
  </tr>
  <tr>
    <td width="233"><font size="2">/s/ Alan S. Rosenthal</font>
      <hr noshade size="1" width="75%" align="left">
      <font size="2"> Alan S. Rosenthal</font></td>
    <td width="235" valign="top"><font size="2">Director</font></td>
    <td width="124" valign="middle"><font size="2">March 20, 2003 </font></td>
  </tr>
</table>
<p>&nbsp;
<hr size=5 noshade width=600 align=LEFT><p>&nbsp;





<!-- *************************************************************************** -->
<!-- MARKER PAGE="sheet: 7; page: 7" -->



<p><table width=600><tr><td><FONT SIZE="2"><U>INDEX TO EXHIBITS</U></FONT></td></tr></table>


<br>
<table width=600>
  <tr>
    <td width="131" align="center"><font size="2">Number</font>
      <hr size="1" noshade align="center" width="30%">
    </td>
    <td width="457" align="center"><font size="2">Exhibit</font>
      <hr size="1" noshade align="left" width="100%">
    </td>
  </tr>
  <tr>
    <td width="131" align="center">&nbsp;</td>
    <td width="457" align="left">&nbsp;</td>
  </tr>
  <tr>
    <td width="131" align="center"><font size="2">5.1</font></td>
    <td width="457" align="left"><font size="2">Opinion of Pillsbury Winthrop
      LLP</font></td>
  </tr>
  <tr>
    <td width="131" align="center" valign="top"><font size="2">10.1</font></td>
    <td width="457" align="left"><font size="2">Stock Option Agreement, dated
      January 13, 2003, by and between The Immune Response Corporation and John
      N. Bonfiglio, Ph.D.</font></td>
  </tr>
  <tr>
    <td width="131" align="center"><font size="2">10.2</font></td>
    <td width="457" align="left"><font size="2">The Immune Response Corporation
      2003 Stock Plan</font></td>
  </tr>
  <tr>
    <td width="131" align="center"><font size="2">23.1</font></td>
    <td width="457" align="left"><font size="2">Consent of BDO Seidman, LLP, Independent
      Public Accountants</font></td>
  </tr>
  <tr>
    <td width="131" align="center"><font size="2">23.3</font></td>
    <td width="457" align="left"><font size="2">Consent of Pillsbury Winthrop
      LLP (included in Exhibit 5.1).</font></td>
  </tr>
  <tr>
    <td width="131" align="center"><font size="2">24.1</font></td>
    <td width="457" align="left"><font size="2">Power of Attorney (see page 6).
      </font></td>
  </tr>
</table>
</body>
</html>
[{"type": "S-8", "sequence": "1", "filename": "k30266_s-8.htm", "description": "FORM S-8", "secsgml_size_bytes": 29453}]
{"company-data": {"conformed-name": "IMMUNE RESPONSE CORP", "cik": "0000817785", "assigned-sic": "2836", "irs-number": "330255679", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-103957", "film-number": "03612113"}, "business-address": {"street1": "5935 DARWIN COURT", "city": "CARLSBAD", "state": "CA", "zip": "92008", "phone": "6194317080"}, "mail-address": {"street1": "5935 DARWIN COURT", "city": "CARLSBAD", "state": "CA", "zip": "92008"}}
Form S-8
As filed with the Securities and Exchange Commission
      on March 21, 2003
Registration No. 333-
SECURITIES AND EXCHANGE
COMMISSION
Washington, D.C. 20549
Form S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
The Immune Response Corporation
(Exact name of registrant as specified in its
      charter)
Delaware
(State or other jurisdiction of
incorporation or organization)
33-0225679
(I.R.S. Employer Identification No.)
5931 Darwin Court
Carlsbad, California
(Address of Principal Executive
      Offices)
92008
(Zip
      Code)
THE IMMUNE RESPONSE CORPORATION
2003 STOCK PLAN
STOCK OPTION GRANT OUTSIDE OF A PLAN
(Full title of the plans)
Copy to:
MICHAEL L. JEUB
Chief Financial Officer
5931 Darwin Court
Carlsbad, CA 92008
(760) 431-7080
(Name, address and telephone number,
including area code, of agent for service)
P. JOSEPH CAMPISI, JR.
Pillsbury Winthrop LLP
50 Fremont Street
San Francisco, CA 94120-7880
(415) 983-1000
CALCULATION OF REGISTRATION FEE
Title of Securities to
be Registered
Amount to be
Registered (2)
Proposed
Maximum
Offering Price per
Share
Proposed Maximum
Aggregate Offering
Price
Amount of
Registration
Fee
Common Stock, par
value $0.0025 (3)
3,250,000 shares
$1.22(1)
$3,965,000(1)
$320.77
Common Stock, par
value $0.0025
750,000 shares
$1.20
$   900,000
$  72.81
Total
4,000,000 shares
—
$4,865,000
$393.58
(1)      Estimated solely for the
      purpose of calculating the registration fee pursuant to Rule 457, based
      upon the average of the high and low prices as reported on the Nasdaq Stock
      Market on March 19, 2003.
(2)      In addition, pursuant to
      Rule 416(c) under the Securities Act of 1933, this registration statement
      also covers an indeterminate amount of interests to be offered or sold pursuant
      to the employee benefit plan described herein.
(3)      The shares as issuable
      pursuant to the respective plans as follows: Stock Option Grant Outside
      of a Plan, 750,000 shares and 2003 Stock Option Plan, 3,250,000 shares.
The
Registration Statement shall become effective upon filing in accordance with Rule 462
under the Securities  Act of 1933.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a)
PROSPECTUS
Item 1.
Plan Information.
*
Item 2.
Registrant Information
      and Employee Plan Annual Information.
*
* Information
required by Part I to be contained in the Section 10(a) prospectus is omitted from  this
Registration Statement in accordance with Rule 428 under the Securities act of 1933 and
the Note  to Part I of Form S-8.
PART II
INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT
Item 3.
Incorporation of Certain Documents by
Reference.
The
following documents filed by Registrant with the Securities and Exchange Commission are
incorporated by  reference in this registration statement:
(1)
     Registrant's Annual Report on Form 10-K, as restated (File No. 0-18006) for the
fiscal year ended  December 31, 2001, which contains, among other things, the
consolidated financial statements of Registrant and certain  supplementary data for the
fiscal year ended December 31, 2001 together with the report therein of BDO Seidman, LLP,
the  Registrant's independent public accountants;
(2)
     Registrant's Quarterly Report on Form 10-Q (File No. 0-18006) for the quarter ended
June 30, 2002;
(3)
           Registrant's Quarterly Report on Form
      10-Q (File No. 0-18006) for the quarter ended September 30, 2002, which
      contains, among other things, the condensed consolidated financial statements
      of the Registrant and certain supplementary data for the quarterly period
      ended September 30, 2002;
(4)
           The description of Registrant's Common
      Stock contained in Registrant's registration statement on Form 8-A,
      filed March 30, 1990.
In
addition, all documents subsequently filed by Registrant pursuant to Sections 13(a),
13(c), 14 and 15(d) of  the Securities Exchange Act of 1934, prior to the filing of a
post-effective amendment which indicates that all  securities offered have been sold or
which deregisters all securities then remaining unsold, shall be deemed to be
incorporated by reference in this registration statement and to be a part hereof from the
date of filing of such  documents.
Item 4.
Description of Securities.
Not
      applicable.
Item 5.
Interests of Named Experts and Counsel.
Certain
legal matters with respect to the validity of  securities  offered  hereby has been
passed upon for us by  Pillsbury  Winthrop  LLP. A partner of  Pillsbury  Winthrop  LLP
owns 1,106 shares of common stock and an option to acquire  5,000 shares of our common
stock.
Item 6.
Indemnification of Directors and
Officers.
Section
145 of the Delaware General Corporation Law, the "Delaware GCL", permits our
board of directors to  indemnify any person against expenses (including attorneys' fees),
judgments, fines and amounts paid in settlement  actually and reasonably incurred by him
in connection with any threatened, pending or completed action, suit or  proceeding in
which such person is made a party by reason of his being or having been a director,
officer, employee or  agent of ours, in terms sufficiently broad to permit such
indemnification under certain circumstances for liabilities  (including reimbursement for
expenses incurred) arising under the Securities Act of 1933, as amended. The Delaware GCL
provides that indemnification pursuant to its provisions is not exclusive of other rights
of indemnification to which a  person may be entitled under any by-law, agreement, vote
of stockholders or disinterested directors, or otherwise.
Article
VII of our Restated Certificate of Incorporation, as amended, and Article V of our
Bylaws, provide for  indemnification of our directors, officers, employees and other
agents to the maximum extent permitted by law. In  addition, we have entered into
separate indemnification agreements with our directors and officers that will require us,
among other things, to indemnify them against certain liabilities that may arise by
reason of their status or service as  directors or officers to the fullest extent not
prohibited by law.
Item 7.
Exemption from Registration Claimed.
Not
      applicable.
Item 8.
Exhibits.
See
      Index to Exhibits.*
Item 9.
Undertakings.
(a)
The undersigned Registrant hereby undertakes:
(1)
          To file, during any period in which offers or sales
      are being made, a post-effective amendment to this registration statement:
(i)     To
      include any prospectus required by section 10(a)(3) of the Securities
      Act of 1933;
(ii)     To
      reflect in the prospectus any facts or events arising after the effective
      date of the registration statement (or the most recent post-effective amendment
      thereof) which, individually or in the aggregate, represent a fundamental
      change in the information set forth in the registration statement;
(iii)
To include any material information with respect to
      the plan of distribution not previously disclosed in the registration statement
      or any material change to such information in the registration statement;
provided,
however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the registration
statement is on  Form S-3 or Form S-8, and the information required to be included
in a post-effective amendment by those  paragraphs is contained in periodic reports filed
by the Registrant pursuant to section 13 or section 15(d) of  the Securities
Exchange Act of 1934 that are incorporated by reference in the registration statement.
(2)
That, for the purpose of determining any liability under the Securities Act of 1933, each
such post-effective  amendment shall be deemed to be a new registration statement
relating to the securities offered therein, and the  offering of such securities at that
time shall be deemed to be the initial bona fide offering thereof.
(3)
To remove from registration by means of a post-effective amendment any of the securities
being registered which  remain unsold at the termination of the offering.
(b)
The undersigned Registrant hereby further undertakes that, for purposes of determining
any liability under the  Securities Act of 1933, each filing of the Registrant's
annual report pursuant to section 13(a) or section 15(d) of the  Securities Exchange
Act of 1934 that is incorporated by reference in the registration statement shall be
deemed to be a  new registration statement relating to the securities offered therein,
and the offering of such securities at that time  shall be deemed to be the initial bona
fide offering thereof.
(c)
Insofar as indemnification for liabilities arising under the Securities Act of 1933 may
be permitted to  directors, officers and controlling persons of the Registrant pursuant
to the foregoing provisions, or otherwise, the  Registrant has been advised that in the
opinion of the Securities and Exchange Commission such indemnification is against  public
policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable.  In
the event that a claim for  indemnification against such liabilities (other than the
payment by the Registrant of expenses incurred or paid by a  director, officer or
controlling person of the Registrant in the successful defense of any action, suit or
proceeding) is  asserted by such director, officer or controlling person in connection
with the securities being registered, the  Registrant will, unless in the opinion of its
counsel the matter has been settled by controlling precedent, submit to a  court of
appropriate jurisdiction the question whether such indemnification by it is against
public policy as expressed  in the Securities Act of 1933 and will be governed by the
final adjudication of such issue.
SIGNATURES
Pursuant
      to the requirements of the Securities Act of 1933, the Registrant certifies
      that it has reasonable grounds to believe that it meets all of the requirements
      for filing on Form S-8, and has duly caused this registration statement
      to be signed on its behalf by the undersigned, thereunto duly authorized,
      in the City of Carlsbad, State of California, on March 20, 2003.
THE IMMUNE RESPONSE CORPORATION
By /s/ Michael L. Jeub
Michael L. Jeub
Chief Financial Officer and Vice President of Finance
POWER OF ATTORNEY
KNOW
ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and
appoints Michael  L. Jeub and Dr. John N. Bonfiglio, and each of them his true and lawful
attorneys-in-fact and agents, each with full  power of substitution and resubstitution,
for him and in his name, place and stead, in any and all capacities, to sign  any and all
amendments, including post-effective amendments, to this registration statement, and to
file the same, with  exhibits thereto and other documents in connection therewith, with
the Securities and Exchange Commission, granting unto  said attorneys-in-fact and agents,
full power and authority to do and perform each and every act and thing requisite and
necessary to be done, as fully to all intents and purposes as he might or could do in
person, hereby ratifying and  confirming all that said attorneys-in-fact and agents, or
his substitute or substitutes, may do or cause to be done by  virtue hereof.
Pursuant
to the requirements of the Securities Act of 1933, this registration statement has been
signed by the  following persons in the capacities and on the date indicated:
Name
Title
Date
/s/ John N. Bonfiglio
John N. Bonfiglio
Chief Executive Officer and Director
March 20, 2003
/s/ Michael L. Jeub
Michael L. Jeub
Chief Financial Officer and Vice
President of Finance
March 20, 2003
Name
Title
Date
/s/ James B. Glavin
James B. Glavin
Chairman of the Board
March 20, 2003
/s/ Kevin B. Kimberlin
Kevin B. Kimberlin
Director
March 20, 2003
/s/ Jed B. Trosper
Jed B. Trosper
Director
March 20, 2003
/s/ Dennis J. Carlo
Dennis J. Carlo
Director
March 20, 2003
/s/ William M. Sullivan
William M. Sullivan
Director
March 20, 2003
/s/ Alan S. Rosenthal
Alan S. Rosenthal
Director
March 20, 2003
INDEX TO EXHIBITS
Number
Exhibit
5.1
Opinion of Pillsbury Winthrop
      LLP
10.1
Stock Option Agreement, dated
      January 13, 2003, by and between The Immune Response Corporation and John
      N. Bonfiglio, Ph.D.
10.2
The Immune Response Corporation
      2003 Stock Plan
23.1
Consent of BDO Seidman, LLP, Independent
      Public Accountants
23.3
Consent of Pillsbury Winthrop
      LLP (included in Exhibit 5.1).
24.1
Power of Attorney (see page 6).