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    <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on October 30, 2023</div>
    <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
    <div>
      <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">WASHINGTON, DC&#160; 20549</div>
    <div>
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    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 24pt; font-weight: bold;">Gyre Therapeutics, Inc.</div>
    <div style="text-align: center;">(Exact name of registrant as specified in its charter)</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z6894a022fda84e1baf71c7a0b592ed64" border="0" cellpadding="0" cellspacing="0">

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          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Delaware</div>
            <div style="text-align: center;">(State or Other Jurisdiction</div>
            <div style="text-align: center;">of Incorporation or Organization)</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">56-2020050</div>
            <div style="text-align: center;">(I.R.S. Employer</div>
            <div style="text-align: center;">Identification No.)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Gyre Therapeutics, Inc.</div>
    <div style="text-align: center; font-weight: bold;">12730 High Bluff Drive, Suite 250</div>
    <div>
      <div style="text-align: center; font-weight: bold;">San Diego, California 92130</div>
      <div style="text-align: center;">(Address, including zip code, of registrant&#8217;s principal executive offices)</div>
    </div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan</div>
    <div style="text-align: center;">(Full title of the plan)</div>
    <div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Charles Wu</div>
      <div style="text-align: center; font-weight: bold;">Chief Executive Officer</div>
      <div style="text-align: center; font-weight: bold;">Gyre Therapeutics, Inc.</div>
      <div style="text-align: center; font-weight: bold;">12730 High Bluff Drive, Suite 250</div>
      <div style="text-align: center; font-weight: bold;">San Diego, California 92130</div>
      <div style="text-align: center; font-weight: bold;">(650) 226-8674</div>
    </div>
    <div style="text-align: center;">(Name, address, and telephone number, including area code, of agent for service)</div>
    <div><br>
    </div>
    <div style="text-align: center;">Copy to:</div>
    <div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Sean Feller</div>
      <div style="text-align: center; font-weight: bold;">Gibson, Dunn &amp; Crutcher LLP</div>
      <div style="text-align: center; font-weight: bold;">2029 Century Park East, Suite 4000</div>
      <div style="text-align: center; font-weight: bold;">Los Angeles, California 90067</div>
      <div style="text-align: center; font-weight: bold;">(310) 552-8500</div>
    </div>
    <div><br>
    </div>
    <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
      filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z4470ff2941fe462a8df4241ba8b64060" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 21.83%; vertical-align: bottom;">
            <div>Large accelerated filer</div>
          </td>
          <td style="width: 51.65%; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman',Times,serif;"> &#9744;</div>
          </td>
          <td style="width: 23.65%; vertical-align: bottom;">
            <div>Accelerated filer</div>
          </td>
          <td style="width: 2.87%; vertical-align: bottom;">
            <div>&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 21.83%; vertical-align: middle;">&#160;</td>
          <td style="width: 51.65%; vertical-align: middle;">&#160;</td>
          <td style="width: 23.65%; vertical-align: middle;">&#160;</td>
          <td style="width: 2.87%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 21.83%; vertical-align: bottom;">
            <div>Non-accelerated filer</div>
          </td>
          <td style="width: 51.65%; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman',Times,serif;"> &#9745;</div>
          </td>
          <td style="width: 23.65%; vertical-align: bottom;">
            <div>Smaller reporting company</div>
          </td>
          <td style="width: 2.87%; vertical-align: bottom;">
            <div>&#9745;</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>Emerging growth company &#9744;</div>
    <div> <br>
    </div>
    <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act.&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; &#9744;
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    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">This Registration Statement on Form S-8 (this &#8220;Registration Statement&#8221;) is being filed by Gyre Therapeutics, Inc., a Delaware corporation (formerly known as Catalyst Biosciences, Inc., the &#8220;Registrant&#8221;), relating to (i)
      17,845,496 shares of common stock of the Registrant, par value $0.001 per share (the &#8220;Common Stock&#8221;), that are authorized for issuance under the Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan (the &#8220;Omnibus Plan&#8221;) and (ii) pursuant to Rule 416(a)
      under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), any additional Common Shares that may become issuable under the Omnibus Plan by reason of any stock dividend, stock split or other similar transaction.</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">PART I</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">The information specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this Registration Statement in accordance with the provisions of Rule 428 under the Securities Act, and the introductory note to Part I
      of the Form S-8 instructions. The documents containing the information specified in Part I of Form S-8 will be delivered to the participants in the Omnibus Plan, as specified by Rule 428(b)(1) under the Securities Act.</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">PART II</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zabe9761fffda493d9e952048484593b7" cellpadding="0" cellspacing="0">

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          <td style="width: 72pt; vertical-align: top; font-weight: bold;">Item 3.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Incorporation of Documents by Reference.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">The following documents filed by the Registrant with the Securities and Exchange Commission (the &#8220;Commission&#8221;), are incorporated by reference herein and shall be deemed to be a part hereof:</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z150585cc85a74662bd9e8e4a377fcae7" cellpadding="0" cellspacing="0">

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          <td style="width: 36pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">1.</td>
          <td style="width: auto; vertical-align: top;">
            <div>The prospectus dated October 27, 2023, filed by the Registrant with the Commission pursuant to Rule 424(b)(3) under the Securities Act, on October 27, 2023, relating to the Registration Statement on Form S-3 (File No. 333-273395), which
              contains the Registrant&#8217;s audited financial statements for the latest fiscal year for which such statements have been filed; and</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="ze13cf9c601834923a9ef7c94eb00a11a" cellpadding="0" cellspacing="0">

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          <td style="width: 36pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">2.</td>
          <td style="width: auto; vertical-align: top;">
            <div>The description of the Common Stock contained in the Registrant&#8217;s Definitive Proxy Statement on Schedule 14A filed with the Commission, on July 20, 2023, including any amendments or reports filed for the purpose of updating such
              description.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">In addition, all documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;) after the date hereof, but prior to the filing of
      a post-effective amendment to this Registration Statement that indicates that all securities offered hereby have been sold or that deregisters all such securities then remaining unsold, shall be deemed to be incorporated by reference in this
      Registration Statement and to be a part hereof from the date of filing of such documents.&#160; Notwithstanding the foregoing, unless specifically stated to the contrary in such filing, none of the information that the Registrant discloses under Items
      2.02 or 7.01 of any Current Report on Form 8-K that it may from time to time furnish to the Commission will be incorporated by reference into, or otherwise be included in or deemed to be a part of, this Registration Statement.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">For purposes of this Registration Statement, any document or any statement contained in a document incorporated or deemed to be incorporated herein by reference shall be deemed to be modified or superseded to the extent
      that a subsequently filed document or a statement contained herein or in any other subsequently filed document that also is or is deemed to be incorporated herein by reference modifies or supersedes such document or such statement in such document.
      Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement. Subject to the foregoing, all information in this Registration Statement is so qualified in its
      entirety by the information appearing in the documents incorporated herein by reference.</div>
    <div style="text-indent: 36pt;"> <br>
    </div>
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    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zef029bcff01c455489810796491d64d2" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 72pt; vertical-align: top; font-weight: bold;">Item 4.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Description of Securities.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">Not applicable.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2bd48b4b1174448c94e8c62f7dc0c469" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 72pt; vertical-align: top; font-weight: bold;">Item 5.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Interests of Named Experts and Counsel.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">Not applicable.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd4bd20860f6341d28aafc7dcfb57f27a" cellpadding="0" cellspacing="0">

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          <td style="width: 72pt; vertical-align: top; font-weight: bold;">Item 6.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Indemnification of Directors and Officers.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">Section 145 of the Delaware General Corporation Law authorizes a court to award, or a corporation&#8217;s board of directors to grant, indemnity to directors and officers under certain circumstances and subject to certain
      limitations. The terms of Section 145 of the Delaware General Corporation Law are sufficiently broad to permit indemnification under certain circumstances for liabilities, including reimbursement of expenses incurred, arising under the Securities
      Act.</div>
    <div><br>
    </div>
    <div>
      <div style="text-align: justify; text-indent: 36pt;">As permitted by the Delaware General Corporation Law, the Registrant&#8217;s restated certificate of incorporation and amended and restated bylaws contain provisions relating to the limitation of
        liability and indemnification of directors and officers. The restated certificate of incorporation provides that the Registrant&#8217;s directors will not be personally liable to us or the Registrant&#8217;s stockholders for monetary damages for any breach of
        fiduciary duty as a director, except for liability:</div>
      <div><br>
      </div>
      <div>
        <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

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              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top;">&#8226;</td>
              <td style="width: auto; vertical-align: top;">
                <div>
                  <div>for any breach of the director&#8217;s duty of loyalty to us or the Registrant&#8217;s stockholders;</div>
                </div>
              </td>
            </tr>

        </table>
        <div> <br>
        </div>
      </div>
    </div>
    <div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

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            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>
                <div style="text-align: justify;">for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law;</div>
              </div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
    </div>
    <div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

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            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>
                <div>under Section 174 of the Delaware General Corporation Law; or</div>
              </div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
    </div>
    <div>
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            <td style="width: 36pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>
                <div>for any transaction from which the director derived an improper personal benefit.</div>
              </div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: justify; text-indent: 36pt;">The Registrant&#8217;s&#160; restated certificate of incorporation also provides that if the Delaware General Corporation Law is amended to authorize corporate action further eliminating or limiting the
        personal liability of directors, then the liability of the Registrant&#8217;s directors will be eliminated or limited to the fullest extent permitted by the Delaware General Corporation Law as so amended.</div>
      <div><br>
      </div>
      <div style="text-align: justify; text-indent: 36pt;">The Registrant&#8217;s amended and restated bylaws provide that the Registrant will indemnify its directors and officers to the fullest extent permitted by Delaware law, as it now exists or may in the
        future be amended (but, in the case of any amendment, only to the extent such amendment permits broader indemnification rights than such law permitted the Registrant prior to such amendment), against all expenses reasonably incurred in connection
        with their service for or on the Registrant&#8217;s behalf. The Registrant&#8217;s amended and restated bylaws provide that it shall advance the expenses incurred by a director or officer in advance of the final disposition of an action or proceeding;
        provided, however, that if the Delaware General Corporation Law so requires, an advancement of expenses incurred by an indemnitee in his or her capacity as a director or officer (and not in any other capacity in which service was or is rendered by
        such indemnitee, including without limitation, service to an employee benefit plan) will be made only upon delivery to the Registrant of an undertaking, by or on behalf of such indemnitee, to repay all amounts so advanced if it is ultimately
        determined that such indemnitee is not entitled to be indemnified by the Registrant under its amended and restated bylaws or otherwise. The Registrant&#8217;s amended and restated bylaws permit it to secure insurance on behalf of any director, officer,
        employee, or agent or individual serving at the request of the Registrant as a director, officer, employee or agent of another corporation, partnership, joint venture, trust, employee benefit plan or other enterprise against any liability asserted
        against such person and incurred by such person in any such capacity, or arising out of such person&#8217;s status as such, whether or not the Registrant would have the power or the obligation to indemnify such person against such liability under the
        provisions of the Registrant&#8217;s amended and restated bylaws.</div>
      <div><br>
      </div>
      <div style="text-align: justify; text-indent: 36pt;">The Registrant has entered into indemnification agreements with each of its directors and with each executive officer. Pursuant to the indemnification agreements, the Registrant has agreed to
        indemnify and hold harmless these directors and officers to the fullest extent permitted by the Delaware General Corporation Law. The agreements generally cover expenses that a director or officer incurs or amounts that a director or officer
        becomes obligated to pay because of any proceeding to which he or she is made or threatened to be made a party or participant by reason of his or her service as a current or former director, officer, employee or agent of the Registrant. The
        agreements also provide for the advancement of expenses to the directors and officers subject to specified conditions. There are certain exceptions to the Registrant&#8217;s obligation to indemnify the directors and officers, including any intentional
        malfeasance or act where the director or officer did not in good faith believe he or she was acting in the Registrant&#8217;s best interests, with respect to &#8220;short-swing&#8221; profit claims under Section 16(b) of the Exchange Act and, with certain
        exceptions, with respect to proceedings that he or she initiates.</div>
      <div style="text-align: justify; text-indent: 36pt;"> <br>
      </div>
    </div>
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    <div>
      <div><br>
      </div>
      <div style="text-align: justify; text-indent: 36pt;">The Registrant maintains insurance policies that indemnify its directors and officers against various liabilities arising under the Securities Act and the Exchange Act that might be incurred by any
        director or officer in his or her capacity as such.</div>
      <div><br>
      </div>
    </div>
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          <td style="width: 72pt; vertical-align: top; font-weight: bold;">Item 7.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Exemption from Registration Claimed.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">Not applicable.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf5e2536b317647e081fcb239262281e7" cellpadding="0" cellspacing="0">

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          <td style="width: 72pt; vertical-align: top; font-weight: bold;">Item 8.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Exhibits.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z6778ed5d66c54707a50d84288265d8f7" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div><u>Exhibit No.</u></div>
          </td>
          <td style="vertical-align: top;">
            <div><u>Exhibit Description</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
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          <td style="vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312506103288/dex41.htm">Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Registration
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        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
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          </td>
          <td style="vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312515297752/d24322dex31.htm">Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit
                3.2 to the Company&#8217;s Registration Statement on Form S-3/A filed on October 24, 2023).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>4.3</div>
          </td>
          <td style="vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000119312517037156/d326649dex31.htm">Second Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to
                Exhibit 3.3 to the Company&#8217;s Registration Statement on Form S-3/A filed on October 24, 2023).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>4.4</div>
          </td>
          <td style="vertical-align: top;">
            <div><a href="ny20009756x9_ex4-4.htm">Third Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>4.5</div>
          </td>
          <td style="vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1124105/000114036122046943/brhc10045912_ex3-1.htm">Certificate of Designation of Series X Convertible Preferred Stock (incorporated by reference to Exhibit 3.4 to the Company&#8217;s Registration
                Statement on Form S-3/A filed on October 24, 2023).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>4.6</div>
          </td>
          <td style="vertical-align: top;">
            <div><a href="ny20009756x9_ex4-6.htm">Amendment to Certificate of Designation of Preferences, Rights and Limitations of Series X Convertible Preferred Stock.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>4.7</div>
          </td>
          <td style="vertical-align: top;">
            <div><a href="ny20009756x9_ex4-7.htm">Amended and Restated Bylaws of the Registrant.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>5.1*</div>
          </td>
          <td style="vertical-align: top;">
            <div><a href="ny20009756x9_ex5-1.htm">Opinion of Gibson, Dunn &amp; Crutcher LLP.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>23.1*</div>
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          <td style="vertical-align: top;">
            <div><a href="ny20009756x9_ex23-1.htm">Consent of EisnerAmper LLP.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>23.2*</div>
          </td>
          <td style="vertical-align: top;">
            <div><a href="ny20009756x9_ex23-2.htm">Consent of Ernst &amp; Young Hua Ming LLP.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>23.3*</div>
          </td>
          <td style="vertical-align: top;">
            <div><a href="ny20009756x9_ex5-1.htm">Consent of Gibson, Dunn &amp; Crutcher LLP (included in Exhibit 5.1).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>24.1*</div>
          </td>
          <td style="vertical-align: top;">
            <div><a href="#POWEROFATTORNEY">Power of Attorney (included on signature page hereto).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>99.1</div>
          </td>
          <td style="vertical-align: top;">
            <div><a href="ny20009756x9_ex99-1.htm">Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 72pt; vertical-align: top;">
            <div>107*</div>
          </td>
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            <div><a href="ny20009756x9_ex107.htm">Filing Fee Table.</a></div>
          </td>
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    </table>
    <div><br>
    </div>
    <div>
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    <div>*Filed herewith.</div>
    <div> <br>
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    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
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    <div><br>
    </div>
    <div><font style="font-weight: bold;">Item 9.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Undertakings.</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z3dc7b5b180344dbb9ad210f4e8c74310" border="0" cellpadding="0" cellspacing="0">

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          <td rowspan="1" style="width: 36pt; vertical-align: top;" nowrap="nowrap">(a)<br>
          </td>
          <td colspan="3" rowspan="1" style="vertical-align: top;" nowrap="nowrap">The undersigned Registrant hereby undertakes:</td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td rowspan="1" style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td rowspan="1" colspan="2" style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">
            <div>(1)</div>
          </td>
          <td colspan="2" style="vertical-align: top;">
            <div>To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</div>
          </td>
        </tr>
        <tr>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td colspan="2" style="vertical-align: top;">&#160;</td>
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        <tr>
          <td colspan="2" style="vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">
            <div>(i)</div>
          </td>
          <td style="vertical-align: top;">
            <div>To include any prospectus required by Section 10(a)(3) of the Securities Act;</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
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        <tr>
          <td colspan="2" style="vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">
            <div>(ii)</div>
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          <td style="vertical-align: top;">
            <div>To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change
              in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered)
              and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no
              more than a 20 percent change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective Registration Statement; and</div>
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          <td colspan="2" style="vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="vertical-align: top;">&#160;</td>
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          <td colspan="2" style="vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">
            <div>(iii)</div>
          </td>
          <td style="vertical-align: top;">
            <div>To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement;</div>
          </td>
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    </table>
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    <div><font style="font-style: italic;">provided</font>, <font style="font-style: italic;">however</font>, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those
      paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement.</div>
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          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">
            <div>(2)</div>
          </td>
          <td style="vertical-align: top;">
            <div>That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
              securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof.</div>
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          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
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          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">
            <div>(3)</div>
          </td>
          <td style="vertical-align: top;">
            <div>To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">
            <div>(b)</div>
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            <div>The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&#8217;s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where
              applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to
              the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
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          <td style="width: 36pt; vertical-align: top;" nowrap="nowrap">&#160;</td>
          <td colspan="2" style="vertical-align: top;">&#160;</td>
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            <div>(c)</div>
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            <div>Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been
              advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other
              than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling
              person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such
              indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</div>
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    </table>
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    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
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    <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
    <div><br>
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    <div style="text-indent: 40.8pt;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
      Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of San Diego, State of California, on the 30th day of October, 2023.</div>
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    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z77232f1ffacc4d23bbda2cd18baaa6c9" cellpadding="0" cellspacing="0">

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            <div style="font-weight: bold;">Gyre Therapeutics, Inc.</div>
          </td>
        </tr>
        <tr>
          <td colspan="1" style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 4%; vertical-align: top;">&#160;</td>
          <td style="width: 46%; vertical-align: top;">&#160;</td>
        </tr>
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            <div style="text-indent: -12pt; margin-left: 12pt;">By:</div>
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            <div>/s/ Charles Wu</div>
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            <div style="text-indent: -12pt; margin-left: 12pt;">Name:</div>
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            <div>Charles Wu, Ph.D.</div>
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            <div style="text-indent: -12pt; margin-left: 12pt;">Title:</div>
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            <div>Chief Executive Officer</div>
          </td>
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    <div style="text-align: center; text-indent: 40.8pt; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
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    <div style="text-indent: 36pt;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Dr. Charles Wu and Ruoyu Chen, or either of them, severally, the individual&#8217;s true and lawful attorney-in-fact
      and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Registration Statement, and any
      registration statement relating to the offering covered by this Registration Statement and filed pursuant to Rule 462(b) under the Securities Act of 1933, and to file the same, with exhibits thereto and other documents in connection therewith, with
      the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all intents and
      purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents or their substitute or substitutes may lawfully do or cause to be done by virtue hereof.</div>
    <div><br>
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    <div style="text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated on October 30, 2023.</div>
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    <div><br>
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            <div style="text-align: center; font-weight: bold;"><u>Signature</u></div>
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          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
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          <td style="width: 35%; vertical-align: top;">
            <div>/s/ Charles Wu</div>
          </td>
          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 64%; vertical-align: middle;">
            <div>Chief Executive Officer and Director (<font style="font-style: italic;">Principal Executive Officer</font>)</div>
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          <td style="width: 35%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div>
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          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
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        <tr>
          <td style="vertical-align: top; width: 35%;">&#160;</td>
          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
          <td style="width: 64%; vertical-align: middle;">&#160;</td>
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            <div>/s/ Ruoyu Chen</div>
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          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 64%; vertical-align: middle;">
            <div>Interim Chief Financial Officer (<font style="font-style: italic;">Principal Financial and Accounting Officer</font>)</div>
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          <td style="width: 35%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div>Ruoyu Chen</div>
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          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="vertical-align: top; width: 35%;">&#160;</td>
          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
          <td style="width: 64%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35%; vertical-align: top;">
            <div>/s/ Ying Luo</div>
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          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 64%; vertical-align: middle;">
            <div>Chairman of the Board</div>
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        <tr>
          <td style="width: 35%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
            <div>
              <div style="margin-left: 0.75pt;">Ying Luo, Ph.D.</div>
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          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="vertical-align: top; width: 35%;">&#160;</td>
          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
          <td style="width: 64%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 35%; vertical-align: top;">
            <div>/s/ Gordon G. Carmichael</div>
          </td>
          <td style="width: 1.47%; vertical-align: middle;">&#160;</td>
          <td rowspan="2" style="width: 64%; vertical-align: middle;">
            <div>Director</div>
          </td>
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{"company-data": {"conformed-name": "GYRE THERAPEUTICS, INC.", "cik": "0001124105", "assigned-sic": "2834", "irs-number": "562020050", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-275222", "film-number": "231361721"}, "business-address": {"street1": "12730 HIGH BLUFF DRIVE, SUITE 250", "city": "SAN DIEGO", "state": "CA", "zip": "92130", "phone": "650-266-8674"}, "mail-address": {"street1": "12730 HIGH BLUFF DRIVE, SUITE 250", "city": "SAN DIEGO", "state": "CA", "zip": "92130"}, "former-company": [{"former-conformed-name": "CATALYST BIOSCIENCES, INC.", "date-changed": "20150820"}, {"former-conformed-name": "TARGACEPT INC", "date-changed": "20000919"}]}
As filed with the Securities and Exchange Commission on October 30, 2023
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC  20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Gyre Therapeutics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
(State or Other Jurisdiction
of Incorporation or Organization)
56-2020050
(I.R.S. Employer
Identification No.)
Gyre Therapeutics, Inc.
12730 High Bluff Drive, Suite 250
San Diego, California 92130
(Address, including zip code, of registrant's principal executive offices)
Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan
(Full title of the plan)
Charles Wu
Chief Executive Officer
Gyre Therapeutics, Inc.
12730 High Bluff Drive, Suite 250
San Diego, California 92130
(650) 226-8674
(Name, address, and telephone number, including area code, of agent for service)
Copy to:
Sean Feller
Gibson, Dunn & Crutcher LLP
2029 Century Park East, Suite 4000
Los Angeles, California 90067
(310) 552-8500
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
      filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☑
Smaller reporting company
☑
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act.                       ☐
EXPLANATORY NOTE
This Registration Statement on Form S-8 (this "Registration Statement") is being filed by Gyre Therapeutics, Inc., a Delaware corporation (formerly known as Catalyst Biosciences, Inc., the "Registrant"), relating to (i)
      17,845,496 shares of common stock of the Registrant, par value $0.001 per share (the "Common Stock"), that are authorized for issuance under the Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan (the "Omnibus Plan") and (ii) pursuant to Rule 416(a)
      under the Securities Act of 1933, as amended (the "Securities Act"), any additional Common Shares that may become issuable under the Omnibus Plan by reason of any stock dividend, stock split or other similar transaction.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
The information specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this Registration Statement in accordance with the provisions of Rule 428 under the Securities Act, and the introductory note to Part I
      of the Form S-8 instructions. The documents containing the information specified in Part I of Form S-8 will be delivered to the participants in the Omnibus Plan, as specified by Rule 428(b)(1) under the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The following documents filed by the Registrant with the Securities and Exchange Commission (the "Commission"), are incorporated by reference herein and shall be deemed to be a part hereof:
1.
The prospectus dated October 27, 2023, filed by the Registrant with the Commission pursuant to Rule 424(b)(3) under the Securities Act, on October 27, 2023, relating to the Registration Statement on Form S-3 (File No. 333-273395), which
              contains the Registrant's audited financial statements for the latest fiscal year for which such statements have been filed; and
2.
The description of the Common Stock contained in the Registrant's Definitive Proxy Statement on Schedule 14A filed with the Commission, on July 20, 2023, including any amendments or reports filed for the purpose of updating such
              description.
In addition, all documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act") after the date hereof, but prior to the filing of
      a post-effective amendment to this Registration Statement that indicates that all securities offered hereby have been sold or that deregisters all such securities then remaining unsold, shall be deemed to be incorporated by reference in this
      Registration Statement and to be a part hereof from the date of filing of such documents.  Notwithstanding the foregoing, unless specifically stated to the contrary in such filing, none of the information that the Registrant discloses under Items
      2.02 or 7.01 of any Current Report on Form 8-K that it may from time to time furnish to the Commission will be incorporated by reference into, or otherwise be included in or deemed to be a part of, this Registration Statement.
For purposes of this Registration Statement, any document or any statement contained in a document incorporated or deemed to be incorporated herein by reference shall be deemed to be modified or superseded to the extent
      that a subsequently filed document or a statement contained herein or in any other subsequently filed document that also is or is deemed to be incorporated herein by reference modifies or supersedes such document or such statement in such document.
      Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement. Subject to the foregoing, all information in this Registration Statement is so qualified in its
      entirety by the information appearing in the documents incorporated herein by reference.
Item 4.
Description of Securities.
Not applicable.
Item 5.
Interests of Named Experts and Counsel.
Not applicable.
Item 6.
Indemnification of Directors and Officers.
Section 145 of the Delaware General Corporation Law authorizes a court to award, or a corporation's board of directors to grant, indemnity to directors and officers under certain circumstances and subject to certain
      limitations. The terms of Section 145 of the Delaware General Corporation Law are sufficiently broad to permit indemnification under certain circumstances for liabilities, including reimbursement of expenses incurred, arising under the Securities
      Act.
As permitted by the Delaware General Corporation Law, the Registrant's restated certificate of incorporation and amended and restated bylaws contain provisions relating to the limitation of
        liability and indemnification of directors and officers. The restated certificate of incorporation provides that the Registrant's directors will not be personally liable to us or the Registrant's stockholders for monetary damages for any breach of
        fiduciary duty as a director, except for liability:
•
for any breach of the director's duty of loyalty to us or the Registrant's stockholders;
•
for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law;
•
under Section 174 of the Delaware General Corporation Law; or
•
for any transaction from which the director derived an improper personal benefit.
The Registrant's  restated certificate of incorporation also provides that if the Delaware General Corporation Law is amended to authorize corporate action further eliminating or limiting the
        personal liability of directors, then the liability of the Registrant's directors will be eliminated or limited to the fullest extent permitted by the Delaware General Corporation Law as so amended.
The Registrant's amended and restated bylaws provide that the Registrant will indemnify its directors and officers to the fullest extent permitted by Delaware law, as it now exists or may in the
        future be amended (but, in the case of any amendment, only to the extent such amendment permits broader indemnification rights than such law permitted the Registrant prior to such amendment), against all expenses reasonably incurred in connection
        with their service for or on the Registrant's behalf. The Registrant's amended and restated bylaws provide that it shall advance the expenses incurred by a director or officer in advance of the final disposition of an action or proceeding;
        provided, however, that if the Delaware General Corporation Law so requires, an advancement of expenses incurred by an indemnitee in his or her capacity as a director or officer (and not in any other capacity in which service was or is rendered by
        such indemnitee, including without limitation, service to an employee benefit plan) will be made only upon delivery to the Registrant of an undertaking, by or on behalf of such indemnitee, to repay all amounts so advanced if it is ultimately
        determined that such indemnitee is not entitled to be indemnified by the Registrant under its amended and restated bylaws or otherwise. The Registrant's amended and restated bylaws permit it to secure insurance on behalf of any director, officer,
        employee, or agent or individual serving at the request of the Registrant as a director, officer, employee or agent of another corporation, partnership, joint venture, trust, employee benefit plan or other enterprise against any liability asserted
        against such person and incurred by such person in any such capacity, or arising out of such person's status as such, whether or not the Registrant would have the power or the obligation to indemnify such person against such liability under the
        provisions of the Registrant's amended and restated bylaws.
The Registrant has entered into indemnification agreements with each of its directors and with each executive officer. Pursuant to the indemnification agreements, the Registrant has agreed to
        indemnify and hold harmless these directors and officers to the fullest extent permitted by the Delaware General Corporation Law. The agreements generally cover expenses that a director or officer incurs or amounts that a director or officer
        becomes obligated to pay because of any proceeding to which he or she is made or threatened to be made a party or participant by reason of his or her service as a current or former director, officer, employee or agent of the Registrant. The
        agreements also provide for the advancement of expenses to the directors and officers subject to specified conditions. There are certain exceptions to the Registrant's obligation to indemnify the directors and officers, including any intentional
        malfeasance or act where the director or officer did not in good faith believe he or she was acting in the Registrant's best interests, with respect to "short-swing" profit claims under Section 16(b) of the Exchange Act and, with certain
        exceptions, with respect to proceedings that he or she initiates.
The Registrant maintains insurance policies that indemnify its directors and officers against various liabilities arising under the Securities Act and the Exchange Act that might be incurred by any
        director or officer in his or her capacity as such.
Item 7.
Exemption from Registration Claimed.
Not applicable.
Item 8.
Exhibits.
Exhibit No.
Exhibit Description
4.1
Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Company's Registration
                Statement on Form S-3/A filed on October 24, 2023).
4.2
Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit
                3.2 to the Company's Registration Statement on Form S-3/A filed on October 24, 2023).
4.3
Second Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to
                Exhibit 3.3 to the Company's Registration Statement on Form S-3/A filed on October 24, 2023).
4.4
Third Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation of the Registrant.
4.5
Certificate of Designation of Series X Convertible Preferred Stock (incorporated by reference to Exhibit 3.4 to the Company's Registration
                Statement on Form S-3/A filed on October 24, 2023).
4.6
Amendment to Certificate of Designation of Preferences, Rights and Limitations of Series X Convertible Preferred Stock.
4.7
Amended and Restated Bylaws of the Registrant.
5.1*
Opinion of Gibson, Dunn & Crutcher LLP.
23.1*
Consent of EisnerAmper LLP.
23.2*
Consent of Ernst & Young Hua Ming LLP.
23.3*
Consent of Gibson, Dunn & Crutcher LLP (included in Exhibit 5.1).
24.1*
Power of Attorney (included on signature page hereto).
99.1
Gyre Therapeutics, Inc. 2023 Omnibus Incentive Plan.
107*
Filing Fee Table.
*Filed herewith.
Item 9.
Undertakings.
(a)
The undersigned Registrant hereby undertakes:
(1)
To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)
To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change
              in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered)
              and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no
              more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective Registration Statement; and
(iii)
To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement;
provided
,
however
, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those
      paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement.
(2)
That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such
              securities at that time shall be deemed to be the initial
bona fide
offering thereof.
(3)
To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)
The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where
              applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to
              the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been
              advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other
              than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling
              person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such
              indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
      Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of San Diego, State of California, on the 30th day of October, 2023.
Gyre Therapeutics, Inc.
By:
/s/ Charles Wu
Name:
Charles Wu, Ph.D.
Title:
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Dr. Charles Wu and Ruoyu Chen, or either of them, severally, the individual's true and lawful attorney-in-fact
      and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Registration Statement, and any
      registration statement relating to the offering covered by this Registration Statement and filed pursuant to Rule 462(b) under the Securities Act of 1933, and to file the same, with exhibits thereto and other documents in connection therewith, with
      the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all intents and
      purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents or their substitute or substitutes may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated on October 30, 2023.
Signature
Title
/s/ Charles Wu
Chief Executive Officer and Director (
Principal Executive Officer
)
Charles Wu, Ph.D.
/s/ Ruoyu Chen
Interim Chief Financial Officer (
Principal Financial and Accounting Officer
)
Ruoyu Chen
/s/ Ying Luo
Chairman of the Board
Ying Luo, Ph.D.
/s/ Gordon G. Carmichael
Director
Gordon G. Carmichael, Ph.D.
/s/ Renate Parry
Director
Renate Parry, Ph.D.
/s/ Han Ying
Director
Han Ying, Ph.D.
/s/ Thomas Eastling
Director
Thomas Eastling
/s/ Nassim Usman
Director
Nassim Usman, Ph.D.
/s/ Songjiang Ma
Songjiang Ma
Director