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    <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on February 24, 2022</div>
    <div>&#160;</div>
    <div style="text-align: right; font-weight: bold;">Registration&#160;No.&#160;333-</div>
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    <div style="text-align: center; font-size: 18pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-size: 18pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div>&#160;</div>
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    <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM&#160;S-8</div>
    <div style="text-align: center; font-size: 18pt; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-size: 12pt; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-size: 12pt; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div>
      <div>&#160;</div>
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    <div style="text-align: center; font-size: 18pt; font-weight: bold;">Kronos Bio, Inc.</div>
    <div style="text-align: center; font-size: 8pt; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
    <div><br>
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            <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Delaware</div>
          </td>
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            <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">82-1895605</div>
          </td>
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            <div style="text-align: center; font-size: 8pt; font-weight: bold;">(State or other jurisdiction of</div>
            <div style="text-align: center; font-size: 8pt; font-weight: bold;">incorporation or organization)</div>
          </td>
          <td style="width: 24.53%; vertical-align: top;">
            <div style="text-align: center; font-size: 8pt; font-weight: bold;">(I.R.S. Employer</div>
            <div style="text-align: center; font-size: 8pt; font-weight: bold;">Identification No.)</div>
          </td>
          <td style="width: 25%; vertical-align: middle;">&#160;</td>
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          <td style="width: 25%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">1300 So. El Camino Real, Suite 400</div>
            <div style="text-align: center; font-weight: bold;">San Mateo, California</div>
          </td>
          <td style="width: 24.53%; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">94402</div>
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            <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 8pt; font-weight: bold;">(Address of Principal Executive Offices)</div>
          </td>
          <td style="width: 24.53%; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 8pt; font-weight: bold;">(Zip Code)</div>
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      <div>&#160;</div>
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    <div style="text-align: center; font-weight: bold;">2020 Equity Incentive Plan</div>
    <div style="text-align: center; font-weight: bold;">2020 Employee Stock Purchase Plan</div>
    <div style="text-align: center; font-size: 8pt; font-weight: bold;">(Full titles of the plans)</div>
    <div>
      <div>&#160;</div>
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    <div style="text-align: center; font-weight: bold;">Norbert Bischofberger, Ph.D.</div>
    <div style="text-align: center; font-weight: bold;">President and Chief Executive Officer</div>
    <div style="text-align: center; font-weight: bold;">Kronos Bio, Inc.</div>
    <div style="text-align: center; font-weight: bold;">1300 So. El Camino Real, Suite 400</div>
    <div style="text-align: center; font-weight: bold;">San Mateo, California 94402</div>
    <div style="text-align: center; font-weight: bold;">(650) 781-5200</div>
    <div style="text-align: center; font-size: 8pt;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
    <div>
      <div>&#160;</div>
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      </div>
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    <div style="text-align: center; font-style: italic; font-weight: bold;">Copies to:</div>
    <div style="text-align: center; font-weight: bold;">Charles J. Bair, Esq.</div>
    <div style="text-align: center; font-weight: bold;">Asa M. Henin, Esq.</div>
    <div style="text-align: center; font-weight: bold;">Cooley LLP</div>
    <div style="text-align: center; font-weight: bold;">4401 Eastgate Mall</div>
    <div style="text-align: center; font-weight: bold;">San Diego, California 92121</div>
    <div style="text-align: center; font-weight: bold;">(858)&#160;550-6000</div>
    <div>&#160;</div>
    <div>
      <hr style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 20%; color: #000000; text-align: center;" align="center" noshade="noshade"> </div>
    <div> <br>
    </div>
    <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
      filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div>&#160;</div>
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            <div style="font-family: 'Times New Roman',Times,serif;">Large accelerated filer</div>
          </td>
          <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Segoe UI Symbol',sans-serif;">&#9746;</div>
          </td>
          <td style="width: 2in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">Smaller reporting company</div>
          </td>
          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Segoe UI Symbol',sans-serif;">&#9744;</div>
          </td>
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          <td style="width: 2in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">Non-accelerated filer</div>
          </td>
          <td style="width: auto; vertical-align: middle; color: rgb(0, 0, 0);">
            <div style="font-family: 'Segoe UI Symbol',sans-serif;">&#9744;</div>
          </td>
          <td style="width: 2in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">Accelerated filer</div>
          </td>
          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Segoe UI Symbol',sans-serif;">&#9744;</div>
          </td>
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          <td style="width: 2in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">Emerging growth company</div>
          </td>
          <td style="width: 1in; vertical-align: middle; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Segoe UI Symbol',sans-serif;">&#9744;</div>
          </td>
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    </table>
    <div>&#160;</div>
    <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
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      <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
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    <div style="text-align: center; font-weight: bold;">INCORPORATION OF DOCUMENTS BY REFERENCE</div>
    <div>&#160;</div>
    <div>This Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a Registration Statement of the Registrant on Form S-8 relating to the same employee benefit plan is
      effective.</div>
    <div>&#160;</div>
    <div style="font-size: 12pt;"><font style="font-size: 10pt;">The Registrant previously registered shares of its Common Stock for issuance under the 2020 Plan and 2020 ESPP under Registration Statements on Form S-8 filed with the Securities and Exchange
        Commission (the &#8220;Commission&#8221;) on </font><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014428/kronoss-8.htm"><font style="font-size: 10pt; font-family: 'Times New Roman',Times,serif;">October 9, 2020</font></a><font style="font-size: 10pt;"> (File No. 333-249424) and </font><a href="https://www.sec.gov/Archives/edgar/data/0001741830/000174183021000019/kronos-forms8x20210323.htm"><font style="font-size: 10pt; font-family: 'Times New Roman',Times,serif;">March
          23, 2021</font></a><font style="font-size: 10pt;"> (File No. 333-254620). Pursuant to General Instruction E to Form S-8, this Registration Statement hereby incorporates by reference the contents of the Registration Statement referenced above.</font></div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

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          <td colspan="3" style="vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">ITEM&#160;8. EXHIBITS.</div>
          </td>
        </tr>
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          <td style="width: 1in; vertical-align: bottom;">
            <div style="text-align: center; font-size: 8pt; font-weight: bold;">Exhibit</div>
            <div style="text-align: center; font-size: 8pt; font-weight: bold;">Number</div>
          </td>
          <td style="width: 0.25in; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif; font-size: 8pt;">&#160;&#160;</div>
          </td>
          <td style="width: auto; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 8pt; font-weight: bold;">Description</div>
          </td>
        </tr>
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          <td style="width: 1in; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
        </tr>
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          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">4.1</div>
          </td>
          <td style="width: 0.25in; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">&#160;&#160;</div>
          </td>
          <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;"><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014473/exhibit31-closing8xkam.htm">Amended and Restated Certificate of Incorporation of the Registrant (incorporated
                by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K (File no. 001-39592), filed with the SEC on October 14, 2020).</a></div>
          </td>
        </tr>
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          <td style="width: 1in; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
        </tr>
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          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">4.2</div>
          </td>
          <td style="width: 0.25in; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">&#160;&#160;</div>
          </td>
          <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;"><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014473/exhibit32-8xkxamendeda.htm">Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit
                3.2 to the Registrant&#8217;s Current Report on Form 8-K (File no. 001-39592), filed with the SEC on October 14, 2020).</a></div>
          </td>
        </tr>
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          <td style="width: 1in; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">4.3</div>
          </td>
          <td style="width: 0.25in; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">&#160;&#160;</div>
          </td>
          <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;"><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014248/exhibit41-sx1a1xformof.htm">Form of Common Stock Certificate of the Registrant (incorporated by reference to
                Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form&#160;S-1&#160;(File No.&#160;333-248925), filed with the SEC on September 18, 2020).</a></div>
          </td>
        </tr>
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          <td style="width: 1in; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">5.1</div>
          </td>
          <td style="width: 0.25in; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">&#160;&#160;</div>
          </td>
          <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;"><a href="ny20002924x3_ex5-1.htm">Opinion of Cooley LLP.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 1in; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">23.1</div>
          </td>
          <td style="width: 0.25in; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">&#160;&#160;</div>
          </td>
          <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;"><a href="ny20002924x3_ex23-1.htm">Consent of Independent Registered Public Accounting Firm.</a></div>
          </td>
        </tr>
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          <td style="width: 1in; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">23.2</div>
          </td>
          <td style="width: 0.25in; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">&#160;&#160;</div>
          </td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-size: 12pt;"><a href="ny20002924x3_ex5-1.htm"><font style="font-size: 10pt;">Consent of Cooley LLP. Reference is made to&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman',Times,serif;">Exhibit
                  5.1</font><font style="font-size: 10pt;">.</font></a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 1in; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">24.1</div>
          </td>
          <td style="width: 0.25in; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">&#160;&#160;</div>
          </td>
          <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;"><a href="#sig">Power of Attorney. Reference is made to the signature page hereto.</a></div>
          </td>
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          <td style="width: 1in; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
        </tr>
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          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">99.1</div>
          </td>
          <td style="width: 0.25in; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">&#160;&#160;</div>
          </td>
          <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;"><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014428/exhibit992-sx8xkronosbioin.htm">Kronos Bio, Inc. 2020 Equity Incentive Plan, and Forms of Option Grant Notice,
                Option Agreement, Notice of Exercise, Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement thereunder (incorporated by reference to Exhibit 99.2 to the Registrant&#8217;s Registration Statement on Form S-8 (File No. 333-249424),
                filed with the SEC on October 9, 2020).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 1in; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 1in; vertical-align: top; color: rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">99.2</div>
          </td>
          <td style="width: 0.25in; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">&#160;&#160;</div>
          </td>
          <td style="width: auto; vertical-align: top; color: rgb(0, 0, 0);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1741830/000162828020014428/exhibit993-sx8xkronosbioin.htm">Kronos Bio, Inc. 2020 Employee Stock Purchase Plan (incorporated by reference to Exhibit 99.3 to the Registrant&#8217;s Registration
                Statement on Form S-8 (File No. 333-249424), filed with the SEC on October 9, 2020).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 1in; vertical-align: top;">&#160;</td>
          <td style="width: 0.25in; vertical-align: bottom;">&#160;</td>
          <td style="width: auto; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
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            <div><a href="ny20002924x3_ex107.htm">Filing fee table.</a></div>
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    <div>Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form&#160;S-8&#160;and has duly caused this registration statement
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    <div>KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Norbert Bischofberger, Ph.D., and Barbara Kosacz, and each of them, as his or her true and lawful&#160;attorneys-in-fact&#160;and agents, each with the full
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          <td style="width: 32.49%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 46.88%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="text-align: center;">February 24, 2022</div>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="text-align: center;">February 24, 2022</div>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
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            <div style="text-align: center;">February 24, 2022</div>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom; color: rgb(0, 0, 0);">
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="text-align: center;">February 24, 2022</div>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="text-align: center;">February 24, 2022</div>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom; color: rgb(0, 0, 0);">
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="text-align: center;">February 24, 2022</div>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="text-align: center;">February 24, 2022</div>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom; color: rgb(0, 0, 0);">
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="text-align: center;">February 24, 2022</div>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="text-align: center;">February 24, 2022</div>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 32.49%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 1.35%; vertical-align: bottom;">&#160;</td>
          <td style="width: 18.24%; vertical-align: bottom; color: rgb(0, 0, 0);">
            <div style="text-align: center;">February 24, 2022</div>
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          <td style="width: 1.04%; vertical-align: bottom;">&#160;</td>
          <td style="width: 46.88%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 18.24%; vertical-align: bottom;">&#160;</td>
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{"company-data": {"conformed-name": "Kronos Bio, Inc.", "cik": "0001741830", "assigned-sic": "2834", "irs-number": "000000000", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-262993", "film-number": "22672655"}, "business-address": {"street1": "1300 S. EL CAMINO REAL", "street2": "SUITE 400", "city": "SAN MATEO", "state": "CA", "zip": "94402", "phone": "212-871-7920"}, "mail-address": {"street1": "1300 S. EL CAMINO REAL", "street2": "SUITE 400", "city": "SAN MATEO", "state": "CA", "zip": "94402"}}
As filed with the Securities and Exchange Commission on February 24, 2022
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Kronos Bio, Inc.
(Exact name of registrant as specified in its charter)
Delaware
82-1895605
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
1300 So. El Camino Real, Suite 400
San Mateo, California
94402
(Address of Principal Executive Offices)
(Zip Code)
2020 Equity Incentive Plan
2020 Employee Stock Purchase Plan
(Full titles of the plans)
Norbert Bischofberger, Ph.D.
President and Chief Executive Officer
Kronos Bio, Inc.
1300 So. El Camino Real, Suite 400
San Mateo, California 94402
(650) 781-5200
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
Charles J. Bair, Esq.
Asa M. Henin, Esq.
Cooley LLP
4401 Eastgate Mall
San Diego, California 92121
(858) 550-6000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
      filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☒
Smaller reporting company
☐
Non-accelerated filer
☐
Accelerated filer
☐
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act.
☐
INCORPORATION OF DOCUMENTS BY REFERENCE
This Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a Registration Statement of the Registrant on Form S-8 relating to the same employee benefit plan is
      effective.
The Registrant previously registered shares of its Common Stock for issuance under the 2020 Plan and 2020 ESPP under Registration Statements on Form S-8 filed with the Securities and Exchange
        Commission (the "Commission") on
October 9, 2020
(File No. 333-249424) and
March
          23, 2021
(File No. 333-254620). Pursuant to General Instruction E to Form S-8, this Registration Statement hereby incorporates by reference the contents of the Registration Statement referenced above.
ITEM 8. EXHIBITS.
Exhibit
Number
Description
4.1
Amended and Restated Certificate of Incorporation of the Registrant (incorporated
                by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File no. 001-39592), filed with the SEC on October 14, 2020).
4.2
Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit
                3.2 to the Registrant's Current Report on Form 8-K (File no. 001-39592), filed with the SEC on October 14, 2020).
4.3
Form of Common Stock Certificate of the Registrant (incorporated by reference to
                Exhibit 4.1 to the Registrant's Registration Statement on Form S-1 (File No. 333-248925), filed with the SEC on September 18, 2020).
5.1
Opinion of Cooley LLP.
23.1
Consent of Independent Registered Public Accounting Firm.
23.2
Consent of Cooley LLP. Reference is made to
Exhibit
                  5.1
.
24.1
Power of Attorney. Reference is made to the signature page hereto.
99.1
Kronos Bio, Inc. 2020 Equity Incentive Plan, and Forms of Option Grant Notice,
                Option Agreement, Notice of Exercise, Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement thereunder (incorporated by reference to Exhibit 99.2 to the Registrant's Registration Statement on Form S-8 (File No. 333-249424),
                filed with the SEC on October 9, 2020).
99.2
Kronos Bio, Inc. 2020 Employee Stock Purchase Plan (incorporated by reference to Exhibit 99.3 to the Registrant's Registration
                Statement on Form S-8 (File No. 333-249424), filed with the SEC on October 9, 2020).
107
Filing fee table.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement
      to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Mateo, State of California, on February 24, 2022.
KRONOS BIO, INC.
By:
/s/ Norbert Bischofberger
Norbert Bischofberger, Ph.D.
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Norbert Bischofberger, Ph.D., and Barbara Kosacz, and each of them, as his or her true and lawful attorneys-in-fact and agents, each with the full
      power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this registration statement (including post-effective amendments), and to file the same, with exhibits thereto
      and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and
      necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitute or substitutes, may
      lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Norbert Bischofberger
President, Chief Executive Officer and Director
February 24, 2022
Norbert Bischofberger, Ph.D.
(Principal Executive Officer)
/s/ Yasir Al-Wakeel
Chief Financial Officer and Head of Corporate Development
February 24, 2022
Yasir Al-Wakeel, BM BCh
(Principal Financial and Accounting Officer)
/s/ Arie Belldegrun
Chair of the Board of Directors
February 24, 2022
Arie Belldegrun, M.D. FACS
/s/ Marianne De Backer
Director
February 24, 2022
Marianne De Backer, Ph.D.
/s/ Roshawn Blunt
Director
February 24, 2022
Roshawn Blunt
/s/ Joshua Kazam
Director
February 24, 2022
Joshua Kazam
/s/ Elena Ridloff
Director
February 24, 2022
Elena Ridloff, CFA
/s/ Otello Stampacchia
Director
February 24, 2022
Otello Stampacchia, Ph.D.
/s/ David Tanen
Director
February 24, 2022
David Tanen
/s/ Taiyin Yang
Director
February 24, 2022
Taiyin Yang, Ph.D.