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    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">As filed with the Securities and Exchange Commission on March 1, 2022</div>
    <div style="text-align: right; color: rgb(0, 0, 0); font-weight: bold;">Registration No. 333-</div>
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      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">UNDER</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;">Bionano Genomics, Inc.</div>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
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            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
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          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">26-1756290</div>
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            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or other jurisdiction of incorporation or organization)</div>
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          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer Identification No.)</div>
            <div>&#160;</div>
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            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California</div>
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          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 49%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">92121</div>
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          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Address of Principal Executive Offices)</div>
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          <td style="width: 2%; vertical-align: top;">&#160;</td>
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            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Zip Code)</div>
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    <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <font style="font-family: 'Times New Roman';"><br>
      </font></div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc. Amended and Restated 2018 Equity Incentive Plan, as amended</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc. 2018 Employee Stock Purchase Plan</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Full titles of the plans)</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">R. Erik Holmlin, Ph.D.</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">President and Chief Executive Officer</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc.</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California 92121</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(858) 888-7600</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">Copies to:</div>
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            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Thomas A. Coll, Esq.</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Phillip S. McGill, Esq.</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Cooley LLP</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">4401 Eastgate Mall</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California 92121</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(858) 550-6000</div>
          </td>
          <td style="width: 4%; vertical-align: top;">&#160;</td>
          <td style="width: 48%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">R. Erik Holmlin, Ph.D.</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">President and Chief Executive Officer</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Bionano Genomics, Inc.</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">9540 Towne Centre Drive, Suite 100</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">San Diego, California 92121</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(858) 888-7600</div>
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    </div>
    <div style="text-align: justify; color: rgb(0, 0, 0);">Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the
      definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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          <td style="width: 43.04%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Large accelerated filer</div>
          </td>
          <td style="width: 6.95%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">&#9746;</div>
          </td>
          <td style="width: 43.04%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Accelerated filer</div>
          </td>
          <td style="width: 6.95%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">&#9744;</div>
          </td>
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          <td style="width: 43.04%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
          </td>
          <td style="width: 6.95%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">&#9744;</div>
          </td>
          <td style="width: 43.04%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Smaller reporting company</div>
          </td>
          <td style="width: 6.95%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">&#9744;</div>
          </td>
        </tr>
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          <td style="width: 43.04%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">Emerging growth company</div>
          </td>
          <td style="width: 6.95%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);">&#9744;</div>
          </td>
          <td style="width: 43.04%; vertical-align: top;">&#160;</td>
          <td style="width: 6.95%; vertical-align: top;">&#160;</td>
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    <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;"> <font style="font-family: 'Times New Roman';"><br>
      </font></div>
    <div style="text-align: justify; color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
      provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
    <div style="text-align: justify; color: #000000; font-family: 'Times New Roman', Times, serif;"><font style="font-family: 'Times New Roman';"> <br>
      </font>
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
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    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">EXPLANATORY NOTE</div>
    <div><br>
    </div>
    <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">This Registration Statement on Form S-8 is being filed by Bionano Genomics, Inc. (the &#8220;</font><font style="font-family: 'Times New Roman'; font-weight: bold; font-style: italic; color: rgb(0, 0, 0);">Registrant</font><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">&#8221;) for the purpose of registering (i) an additional </font><font style="font-family: 'Times New Roman';">14,471,651<font style="color: rgb(0, 0, 0);"> shares of Registrant&#8217;s Common Stock, par value $0.0001 per share (&#8220;</font><font style="font-weight: bold; font-style: italic; color: rgb(0, 0, 0);">Common Stock</font><font style="color: rgb(0, 0, 0);">&#8221;), under the Registrant&#8217;s 2018 Equity Incentive Plan, as amended (the &#8220;</font><font style="font-weight: bold; font-style: italic; color: rgb(0, 0, 0);">2018 Plan</font><font style="color: rgb(0, 0, 0);">&#8221;), pursuant
          to the provisions of the 2018 Plan providing for an automatic increase in the number of shares of Common Stock reserved and available for issuance under the 2018 Plan, and (ii) </font>220,000 additional shares of Common Stock under the
        Registrant&#8217;s 2018 Employee Stock Purchase Plan (the &#8220;<font style="font-weight: bold; font-style: italic;">2018 ESPP</font>&#8221;) pursuant to the provisions of the 2018 ESPP providing for an automatic increase in the number of shares of Common Stock
        reserved and available for issuance under the 2018 ESPP.</font></div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">INCORPORATION OF DOCUMENTS BY REFERENCE</div>
    <div><br>
    </div>
    <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;"><font style="font-family: 'Times New Roman';">These additional shares of Common Stock are securities of the same class as other securities for which a Registration
        Statement of the Registrant on Form S-8 relating to the 2018 Plan and the 2018 ESPP are effective. The Registrant previously registered shares of its Common Stock for issuance under the 2018 Plan and 2018 ESPP under Registration Statements on Form
        S-8 filed with the Securities and Exchange Commission on <a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518260602/d616702ds8.htm">August 28, 2018 (File No. 333-227073)</a>, <a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312519091060/d626460ds8.htm">March 29, 2019 (File No. 333-230589)</a>, <a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036120005371/nt10009730x2_s8.htm">March 11, 2020
          (File No. 333-237069)</a>, <a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036120018366/nt10014149x1_s8.htm">August 14, 2020 (File No. 333-245764)</a> and <a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036121009780/nt10022040x2_s8.htm">March 24, 2021 (File No. 333-254654)</a>. Pursuant to General Instruction E to Form S-8, this Registration Statement hereby incorporates by reference
        the contents of the Registration Statements referenced above.</font></div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="za00101e3ce8648d39b530db2c000053b" style="width: 100%; font-family: 'Times New Roman'; font-size: 10pt;">

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              <div style="text-align: left; color: rgb(0, 0, 0); font-weight: bold;">ITEM 8.</div>
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            <td style="vertical-align: top;">
              <div style="text-align: left; color: rgb(0, 0, 0); font-weight: bold;">EXHIBITS.</div>
            </td>
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    <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <font style="font-family: 'Times New Roman';"><br>
      </font></div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z487a52d650474c0687009d41923e2ddd">

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            <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibit</div>
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Number</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Description</div>
          </td>
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          <td style="width: 8.16%; vertical-align: top;">
            <div>4.1(1)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/0001411690/000141169021000004/ex31-arcertificateofincorp.htm">Amended and Restated Certificate of Incorporation of the Registrant, as amended</a><font style="color: rgb(0, 0, 0);">.</font></div>
          </td>
        </tr>
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          <td style="width: 8.16%; vertical-align: top;">
            <div>4.2(2)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518257763/d607608dex32.htm">Amended and Restated Bylaws of the Registrant</a><font style="color: rgb(0, 0, 0);">.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.16%; vertical-align: top;">
            <div>4.3(3)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518219135/d782664dex41.htm">Form of Common Stock Certificate of the Registrant</a><font style="color: rgb(0, 0, 0);">.</font></div>
          </td>
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          <td style="width: 8.16%; vertical-align: top;">
            <div>5.1</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10034627_ex5-1.htm">Opinion of Cooley LLP.</a></div>
          </td>
        </tr>
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          <td style="width: 8.16%; vertical-align: top;">
            <div>23.1</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10034627_ex23-1.htm">Consent of BDO USA LLP, Independent Registered Public Accounting Firm.</a></div>
          </td>
        </tr>
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          <td style="width: 8.16%; vertical-align: top;">
            <div>23.2</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10034627_ex5-1.htm">Consent of Cooley LLP. Reference is made to Exhibit 5.1.</a></div>
          </td>
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          <td style="width: 8.16%; vertical-align: top;">
            <div>24.1</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);"><a href="#POWEROFATTORNEY">Power of Attorney. Reference is made to the signature page hereto.</a></div>
          </td>
        </tr>
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          <td style="width: 8.16%; vertical-align: top;">
            <div>99.1(4)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000114036120018366/nt10014149x1_ex99-1.htm">Bionano Genomics, Inc. 2018 Equity Incentive Plan, as amended</a><font style="color: rgb(0, 0, 0);">.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.16%; vertical-align: top;">
            <div>99.2(5)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518219135/d782664dex105.htm">Forms of Stock Option Grant Notice, Option Agreement and Notice of Exercise under the 2018 Plan</a><font style="color: rgb(0, 0, 0);">.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.16%; vertical-align: top;">
            <div>99.3(6)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000141169021000024/bngo-20210630xexx101.htm">Forms of Restricted Stock Unit Grant Notice and Restricted Stock Unit Award Agreement under the 2018 Plan</a><font style="color: rgb(0, 0, 0);">.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.16%; vertical-align: top;">
            <div>99.3(5)</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1411690/000119312518219135/d782664dex106.htm">Bionano Genomics, Inc. 2018 Employee Stock Purchase Plan</a><font style="color: rgb(0, 0, 0);">.</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.16%; vertical-align: top;">
            <div>107</div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 89.84%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10034627_ex107.htm">Filing Fee Table.</a></div>
          </td>
        </tr>

    </table>
    <div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z3efa5aa7367f4f35811e1b3ced1bb7ff">

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            <td style="width: 3%; vertical-align: top;">
              <div style="text-align: justify; color: rgb(0, 0, 0);">(1)</div>
            </td>
            <td style="width: 97%; vertical-align: top;">
              <div style="text-align: justify; color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Annual Report on Form 10-K, filed with the SEC on March 23, 2021.</div>
            </td>
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          <tr>
            <td style="width: 3%; vertical-align: top;">
              <div style="text-align: justify; color: rgb(0, 0, 0);">(2)</div>
            </td>
            <td style="width: 97%; vertical-align: top;">
              <div style="text-align: justify; color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Current Report on Form 8-K, filed with the SEC on August 24, 2018.</div>
            </td>
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          <tr>
            <td style="width: 3%; vertical-align: top;">
              <div style="text-align: justify; color: rgb(0, 0, 0);">(3)</div>
            </td>
            <td style="width: 97%; vertical-align: top;">
              <div style="text-align: justify; color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Registration Statement on Form S-1 (File No. 333-225970), as amended.</div>
            </td>
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            <td style="width: 3%; vertical-align: top;">
              <div style="text-align: justify; color: rgb(0, 0, 0);">(4)</div>
            </td>
            <td style="width: 97%; vertical-align: top;">
              <div style="text-align: justify; color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Registration Statement on Form S-8 (File No. 333-245764).</div>
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              <div style="text-align: justify; color: rgb(0, 0, 0);">(5)</div>
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              <div style="text-align: justify; color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Registration Statement on Form S-8 (File No. 333-227073).</div>
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              <div style="text-align: justify; color: rgb(0, 0, 0);">(6)</div>
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              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;"><font style="font-family: 'Times New Roman'; color: rgb(0, 0, 0);">Incorporated by reference to the Registrant&#8217;s Quarterly Report on Form 10-Q, filed with the SEC
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    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">SIGNATURES</div>
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    <div style="text-align: justify; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
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            <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0);">/s/ R. Erik Holmlin, Ph.D.</div>
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    <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-family: 'Times New Roman';"><a name="tPOWER"></a></font></div>
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    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">POWER OF ATTORNEY<a name="POWEROFATTORNEY"><!--Anchor--></a></div>
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    <div style="text-align: justify; color: rgb(0, 0, 0);">KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints R. Erik Holmlin, Ph.D. as his or her true and lawful attorney-in-fact and agent, with the full
      power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with exhibits thereto
      and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and
      about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by
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    <div style="text-align: justify; color: rgb(0, 0, 0);">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</div>
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            <div style="text-align: center; color: rgb(0, 0, 0);">/s/ R. Erik Holmlin, Ph.D.</div>
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            <div style="text-align: center; color: rgb(0, 0, 0);">March 1, 2022</div>
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          <td style="width: 30%; vertical-align: top; text-align: center;">
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          <td style="width: 50.02%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
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          <td style="width: 50.02%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 15.76%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 30%; vertical-align: top; text-align: center;">
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          <td style="width: 50.02%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 30%; vertical-align: top; text-align: center;">
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          <td style="width: 50.02%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 15.76%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 50.02%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 15.76%; vertical-align: top; text-align: center;">&#160;</td>
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As filed with the Securities and Exchange Commission on March 1, 2022
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Bionano Genomics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
26-1756290
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification No.)
9540 Towne Centre Drive, Suite 100
San Diego, California
92121
(Address of Principal Executive Offices)
(Zip Code)
Bionano Genomics, Inc. Amended and Restated 2018 Equity Incentive Plan, as amended
Bionano Genomics, Inc. 2018 Employee Stock Purchase Plan
(Full titles of the plans)
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
Bionano Genomics, Inc.
9540 Towne Centre Drive, Suite 100
San Diego, California 92121
(858) 888-7600
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
Thomas A. Coll, Esq.
Phillip S. McGill, Esq.
Cooley LLP
4401 Eastgate Mall
San Diego, California 92121
(858) 550-6000
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
Bionano Genomics, Inc.
9540 Towne Centre Drive, Suite 100
San Diego, California 92121
(858) 888-7600
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the
      definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☒
Accelerated filer
☐
Non-accelerated filer
☐
Smaller reporting company
☐
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
      provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY NOTE
This Registration Statement on Form S-8 is being filed by Bionano Genomics, Inc. (the "
Registrant
") for the purpose of registering (i) an additional
14,471,651
shares of Registrant's Common Stock, par value $0.0001 per share ("
Common Stock
"), under the Registrant's 2018 Equity Incentive Plan, as amended (the "
2018 Plan
"), pursuant
          to the provisions of the 2018 Plan providing for an automatic increase in the number of shares of Common Stock reserved and available for issuance under the 2018 Plan, and (ii)
220,000 additional shares of Common Stock under the
        Registrant's 2018 Employee Stock Purchase Plan (the "
2018 ESPP
") pursuant to the provisions of the 2018 ESPP providing for an automatic increase in the number of shares of Common Stock
        reserved and available for issuance under the 2018 ESPP.
INCORPORATION OF DOCUMENTS BY REFERENCE
These additional shares of Common Stock are securities of the same class as other securities for which a Registration
        Statement of the Registrant on Form S-8 relating to the 2018 Plan and the 2018 ESPP are effective. The Registrant previously registered shares of its Common Stock for issuance under the 2018 Plan and 2018 ESPP under Registration Statements on Form
        S-8 filed with the Securities and Exchange Commission on
August 28, 2018 (File No. 333-227073)
,
March 29, 2019 (File No. 333-230589)
,
March 11, 2020
          (File No. 333-237069)
,
August 14, 2020 (File No. 333-245764)
and
March 24, 2021 (File No. 333-254654)
. Pursuant to General Instruction E to Form S-8, this Registration Statement hereby incorporates by reference
        the contents of the Registration Statements referenced above.
ITEM 8.
EXHIBITS.
Exhibit
Number
Description
4.1(1)
Amended and Restated Certificate of Incorporation of the Registrant, as amended
.
4.2(2)
Amended and Restated Bylaws of the Registrant
.
4.3(3)
Form of Common Stock Certificate of the Registrant
.
5.1
Opinion of Cooley LLP.
23.1
Consent of BDO USA LLP, Independent Registered Public Accounting Firm.
23.2
Consent of Cooley LLP. Reference is made to Exhibit 5.1.
24.1
Power of Attorney. Reference is made to the signature page hereto.
99.1(4)
Bionano Genomics, Inc. 2018 Equity Incentive Plan, as amended
.
99.2(5)
Forms of Stock Option Grant Notice, Option Agreement and Notice of Exercise under the 2018 Plan
.
99.3(6)
Forms of Restricted Stock Unit Grant Notice and Restricted Stock Unit Award Agreement under the 2018 Plan
.
99.3(5)
Bionano Genomics, Inc. 2018 Employee Stock Purchase Plan
.
107
Filing Fee Table.
(1)
Incorporated by reference to the Registrant's Annual Report on Form 10-K, filed with the SEC on March 23, 2021.
(2)
Incorporated by reference to the Registrant's Current Report on Form 8-K, filed with the SEC on August 24, 2018.
(3)
Incorporated by reference to the Registrant's Registration Statement on Form S-1 (File No. 333-225970), as amended.
(4)
Incorporated by reference to the Registrant's Registration Statement on Form S-8 (File No. 333-245764).
(5)
Incorporated by reference to the Registrant's Registration Statement on Form S-8 (File No. 333-227073).
(6)
Incorporated by reference to the Registrant's Quarterly Report on Form 10-Q, filed with the SEC
                  on
August 4,
2021.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
      S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on March 1, 2022.
BIONANO GENOMICS, INC.
By:
/s/ R. Erik Holmlin, Ph.D.
R. Erik Holmlin, Ph.D.
President and Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints R. Erik Holmlin, Ph.D. as his or her true and lawful attorney-in-fact and agent, with the full
      power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with exhibits thereto
      and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and
      about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by
      virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ R. Erik Holmlin, Ph.D.
President, Chief Executive Officer and Director
(Principal Executive Officer)
March 1, 2022
R. Erik Holmlin, Ph.D.
/s/ Christopher Stewart
Chief Financial Officer
(Principal Financial and Accounting Officer)
March 1, 2022
Christopher Stewart
/s/ David L. Barker, Ph.D.
Director
March 1, 2022
David L. Barker, Ph.D.
/s/ Yvonne Linney, Ph.D.
Director
March 1, 2022
Yvonne Linney, Ph.D.
/s/ Albert A. Luderer, Ph.D.
Director
March 1, 2022
Albert A. Luderer, Ph.D.
/s/ Hannah Mamuszka
Director
March 1, 2022
Hannah Mamuszka
/s/ Christopher Twomey
Director
March 1, 2022
Christopher Twomey
/s/ Aleksandar Rajkovic, M.D., Ph.D.
Director
March 1, 2022
Aleksandar Rajkovic, M.D., Ph.D.
/s/ Kristiina Vuori, M.D., Ph.D.
Director
March 1, 2022
Kristiina Vuori, M.D., Ph.D.
/s/ Vincent Wong, J.D., M.B.A.
Director
March 1, 2022
Vincent Wong, J.D., M.B.A.