<HTML>
<HEAD>
   <TITLE>EDGARized at Vintage Filings, LLC</TITLE>
</HEAD>

<BODY bgcolor="#ffffff">


<A name="page_1"></A>

<TABLE align="center">
  <TR>
    <TD> <FONT size=1 face="serif">As filed with the Securities and Exchange Commission
      on July 6, 2004</FONT></TD>
  </TR>
</TABLE>
<div align="center"></div>
<div align="right">
<TABLE><TR><TD height="40" nowrap>
<FONT size=1 face="serif">Registration No. __________________</FONT>
</TD></TR></TABLE>
</div>
<BR>
<hr noshade size="4" width="100%">
<P align="center">
<B><FONT size=4 face="serif">UNITED STATES </FONT></B></P>
<P align="center">
<B><FONT size=4 face="serif">SECURITIES AND EXCHANGE COMMISSION</FONT></B></P>
<P align="center">
<B><FONT size=2 face="serif">Washington, D.C. 20549 </FONT></B></P>
<P align="center">
<FONT face="serif">___________________ </FONT></P>
<P align="center">
<B><FONT size=4 face="serif">FORM S-8 </FONT></B></P>
<P align="center">
<B><FONT face="serif">REGISTRATION STATEMENT </FONT></B></P>
<P align="center">
<B><FONT face="serif">UNDER </FONT></B></P>
<P align="center"> <B><FONT face="serif">THE SECURITIES ACT OF 1933</FONT></B><FONT face="serif">
<BR>___________________ </FONT></P>
<P align="center">
<B><FONT size=4 face="serif">INSITE VISION INCORPORATED </FONT></B></P>
<P align="center">
<FONT size=1 face="serif">(Exact Name of Registrant as Specified in Its Charter) </FONT></P>
<P align="center">
<FONT face="serif">___________________ </FONT></P>
<TABLE width="100%" border=0 cellpadding=0 cellspacing=0>
  <TR>
    <TD width = 33> </TD>
    <TD width = 33%> </TD>
    <TD width = 33%> <div align="center"></div></TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=center> <FONT size=2 face="serif">Delaware</FONT>&nbsp;
    </TD>
    <TD width="33%">&nbsp; </TD>
    <TD nowrap colspan=1 align=right> <div align="center"><FONT size=2 face="serif">94-3015807</FONT>&nbsp;
      </div></TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=center> <FONT size=1 face="serif">(State or Other
      Jurisdiction of</FONT>&nbsp; </TD>
    <TD width="33%">&nbsp; </TD>
    <TD nowrap colspan=1 align=right> <div align="center"><FONT size=1 face="serif">(I.R.S.
        Employer</FONT>&nbsp; </div></TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=center> <FONT size=1 face="serif">Incorporation
      or Organization)</FONT>&nbsp; </TD>
    <TD width="33%">&nbsp; </TD>
    <TD nowrap colspan=1 align=right> <div align="center"><FONT size=1 face="serif">Identification
        No.)</FONT>&nbsp; </div></TD>
  </TR>
</TABLE>
<BR>
<P align="center"><FONT size=2 face="serif">965 Atlantic Avenue<br>Alameda, California 94501<br> </FONT>
<FONT size=1 face="serif">(Address, Including Zip Code, of Principal Executive Offices)</FONT></P>
<P align="center">
<FONT face="serif">___________________ </FONT></P>
<P align="center"> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B><FONT face="serif">InSite
  Vision Incorporated 1994 Stock Option Plan <br>
  InSite Vision Incorporated 1994 Employee Stock Purchase Plan</FONT></B></P>
<P align="center">
<FONT size=1 face="serif">(Full Title of the Plan(s)) </FONT></P>
<P align="center">
<FONT face="serif">___________________ </FONT></P>
<P align="center"> <B><FONT size=2 face="serif">S. Kumar Chandrasekaran, Ph.D.<br>
  Chief Executive Officer<br>
  InSite Vision Incorporated <br>
  965 Atlantic Avenue <br>
  Alameda, California 94501 <br>
  (510) 865-8800 </FONT></B></P>
<P align="center">
<FONT size=1 face="serif">(Name, Address and Telephone Number, Including Area Code, of Agent For Service)</FONT></P>
<TABLE width="100%">
  <TR>
    <TD width="76%" align="center" nowrap> <FONT size=2 face="serif">COPY TO: </FONT><BR> <B><FONT size=2 face="serif">Timothy
      R. Curry, Esq. </FONT></B><BR> <B><FONT size=2 face="serif">O'Melveny &amp;
      Myers LLP </FONT></B><BR> <B><FONT size=2 face="serif">2765 Sand Hill Road
      </FONT></B><BR> <B><FONT size=2 face="serif">Menlo Park, California 94025
      </FONT></B><BR> <B><FONT size=2 face="serif">(650) 473-2600 </FONT></B><BR>
      <FONT face="serif">___________________ </FONT><BR><br>
<FONT face="serif">CALCULATION
      OF REGISTRATION FEE</FONT><BR> </TD>
  </TR>
</TABLE>
<hr noshade size=1>
<TABLE width="100%" border=0 cellpadding=0 cellspacing=0>
  <TR>
    <TD width = 20%> </TD>
    <TD width = 0%> </TD>
    <TD width = 20%> </TD>
    <TD width = 0%> </TD>
    <TD width = 20%> </TD>
    <TD width = 0%> </TD>
    <TD width = 20%> </TD>
    <TD width = 0%> </TD>
    <TD width = 20%> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Proposed</FONT>
    </TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;Title Of</FONT>&nbsp;
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Amount</FONT> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Proposed</FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Maximum</FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Amount Of</FONT>
    </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;Securities</FONT>&nbsp;
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">To Be</FONT> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Maximum Offering</FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Aggregate</FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Registration</FONT>
    </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;To Be Registered</FONT>&nbsp;
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Registered</FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Price Per Share</FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Offering Price</FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">Fee</FONT> </TD>
  </TR>
  <TR>
    <TD colspan =1> <HR noshade size=1> </TD>
    <TD><HR noshade size=1> </TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
    <TD><HR noshade size=1> </TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
    <TD><HR noshade size=1> </TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
    <TD><HR noshade size=1> </TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;Common Stock,</FONT>&nbsp;
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;$0.01
      par value,</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">1,586,123<sup>(1)</sup></FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">$0.67 <sup>(2)</sup></FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">$1,062,702.41<sup>(2)</sup></FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif"> <font size=2 face="serif">$</font>
      134.64<sup>(2)</sup></font></TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;issuable under
      the</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">shares</FONT> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;1994 Stock Option</FONT>&nbsp;
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;Plan</FONT>&nbsp;
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
</TABLE>
<hr noshade size=1>

<BR>
<HR noshade align="center" width="100%" size=2>
<PAGE>


<A name="page_2"></A>
<hr noshade size=1>

<TABLE border=0 cellpadding=0 cellspacing=0 width="100%">
  <TR>
    <TD width = 20%> </TD>
    <TD> </TD>
    <TD width = 20% align="left"> </TD>
    <TD></TD>
    <TD width = 20% align="left"> </TD>
    <TD> </TD>
    <TD width = 20% align="left"> </TD>
    <TD> </TD>
    <TD width = 20% align="left"> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;Common
      Stock,</FONT>&nbsp; </TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD nowrap colspan=1 align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD nowrap colspan=1 align=left>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;$0.01
      par value,</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">350,000<sup>(1)</sup></FONT>
    </TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">$0.67<sup>(2)</sup></FONT>
    </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">$234,500.00<sup>(2)</sup></FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">$29.71<sup>(2)</sup></FONT>
    </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;issuable
      under the</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">shares</FONT> </TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;1994
      Employee</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;Stock
      Purchase</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;Plan</FONT>&nbsp;
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
  <TR>
    <TD colspan =1> <HR noshade size=1> </TD>
    <TD><HR noshade size=1> </TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
    <TD colspan =1><HR noshade size=1></TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
    <TD colspan =1> <HR noshade size=1> </TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
    <TD><HR noshade size=1> </TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
  </TR>
  <TR>
    <TD width="20%">&nbsp; </TD>
    <TD>&nbsp;</TD>
    <TD width="20%">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD width="20%" align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD width="20%" align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD width="20%" align="left">&nbsp;</TD>
  </TR>
  <TR>
    <TD width="20%">&nbsp; </TD>
    <TD>&nbsp;</TD>
    <TD width="20%">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD width="20%" align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD width="20%" align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD width="20%" align="left">&nbsp;</TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">&nbsp;&nbsp;&nbsp;Totals</FONT>&nbsp;
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">1,936,123</FONT>
    </TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">$0.67<sup>(2)</sup></FONT>
    </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">$1,297,202.41<sup>(2)</sup></FONT>
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">164.35<sup>(2)</sup></FONT>
    </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> <FONT size=2 face="serif">shares</FONT> </TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> </TD>
  </TR>
  <TR>
    <TD colspan =1> <HR noshade size=1> </TD>
    <TD><HR noshade size=1> </TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
    <TD colspan =1><HR noshade size=1></TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
    <TD colspan =1> <HR noshade size=1> </TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
    <TD><HR noshade size=1> </TD>
    <TD colspan =1 align="left"> <HR noshade size=1> </TD>
  </TR>
</TABLE>
<BR>
<TABLE border=0 cellspacing=0 cellpadding=0>
<TR valign="top">
	<TD nowrap>
<FONT size=1 face="serif">(1)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
	<TD colspan=1>
<FONT size=2 face="serif">This Registration Statement covers, in addition to the number of shares of InSite Vision Incorporated, a Delaware corporation (the "Company") common stock, par value $0.01 per share (the "Common Stock"), stated above,
options and other rights to purchase or acquire the shares of Common Stock covered by this Registration Statement and, pursuant to Rule 416(c) under the Securities Act of 1933, as amended (the "Securities Act"), an additional indeterminate number of
shares, options and rights that may be offered or issued pursuant to the InSite Vision Incorporated 1994 Stock Option Plan and the InSite Vision Incorporated 1994 Employee Stock Purchase Plan (together, the "Plans"), as a result of one or more
adjustments under the Plans to prevent dilution resulting from one or more stock splits, stock dividends or similar transactions.</FONT>	</TD>
</TR>
<TR valign="top"><TD colspan=2>&nbsp;</TD></TR><TR valign="top">
	<TD nowrap>
<FONT size=1 face="serif">(2)</FONT></TD>
	<TD colspan=1>
<FONT size=2 face="serif">Pursuant to Rule 457(h), the maximum offering price, per share and in the aggregate, and the registration fee were calculated based upon the average of the high and low prices of the Common Stock on June 29, 2004, as
reported by the American Stock Exchange.</FONT>	</TD>
</TR>
<TR valign="top"><TD colspan=2>&nbsp;</TD></TR><TR valign="top">
<TD>&nbsp;</TD>	<TD colspan=1>
<FONT size=2 face="serif">The Exhibit Index for this Registration Statement is at page 7.</FONT>	</TD>
</TR>
<TR valign="top"><TD colspan=2>&nbsp;</TD></TR></TABLE>

<HR noshade align="center" width="100%" size=2>
<PAGE>


<A name="page_3"></A>

<P align="center">
<B><FONT face="serif">EXPLANATORY NOTE</FONT></B><FONT face="serif"> </FONT></P>
<P align="left"> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">This Registration
  Statement is filed by the Company to register additional securities issuable
  pursuant to the Plans and consists of only those items required by General Instruction
  E to Form S-8. </FONT></P>
<P align="center">
<FONT face="serif">_________________________ </FONT></P>
<P align="center">
<TABLE align="center"><TR><TD nowrap>
<B><FONT face="serif">PART I</FONT></B><BR>
</TD></TR></TABLE>
<TABLE align="center"><TR><TD align="center" nowrap>
<FONT face="serif">INFORMATION REQUIRED IN THE</FONT><BR>
<FONT face="serif">SECTION 10(a) PROSPECTUS </FONT><BR>
</TD></TR></TABLE>
</P>
<P>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">The document(s) containing the information specified in Part I of Form S-8 (plan information and registrant information) will be sent or given to employees as specified by Securities Act Rule
428(b)(1). Such documents need not be filed with the Securities and Exchange Commission (the "Commission") either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Securities Act Rule 424. These
documents, which include the statement of availability required by Item 2 of Form S-8, and the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Form S-8 (Part II hereof), taken together, constitute a
prospectus that meets the requirements of Section 10(a) of the Securities Act. </FONT></P>
<P align="center">
<div align="center">
  <TABLE>
    <TR>
      <TD nowrap> <FONT size=2 face="serif">2</FONT><BR> </TD>
    </TR>
  </TABLE></P>
  </div>
<HR noshade align="center" width="100%" size=2>
<PAGE>


<A name="page_4"></A>

<P align="center">
<div align="center">
  <TABLE>
    <TR>
      <TD nowrap> <B><FONT face="serif">PART II</FONT></B><BR> </TD>
    </TR>
  </TABLE>
  <TABLE>
    <TR>
      <TD nowrap> <div align="center"><FONT face="serif">INFORMATION REQUIRED
          IN THE</FONT><BR>
          <FONT face="serif">REGISTRATION STATEMENT </FONT><BR>
        </div></TD>
    </TR>
  </TABLE></P>
  </div>
<P>
<B><FONT face="serif">Item 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporation of Certain Documents by Reference</FONT></B><FONT face="serif"> </FONT></P>
<P>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">The following documents of the Company filed with the Commission are incorporated herein by reference:</FONT></P>
<TABLE border=0 cellspacing=0 cellpadding=0>
  <TR>
    <TD nowrap valign=top>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap valign=top> <FONT face="serif">(a)</FONT>&nbsp; &nbsp; &nbsp; </TD>
    <TD colspan=1> <FONT face="serif">The Company's Registration Statements on
      Form S-8, filed with the Commission on October 23, 2001, August 11, 2000,
      June 2, 1999, July 28, 1998, and June 23, 1997 (Commission File Nos. 333-72098,
      333-43504, 333-79789, 333-60057, and 333-29801, respectively);</FONT> </TD>
  </TR>
  <TR>
    <TD colspan=3>&nbsp;</TD>
  </TR>
  <TR>
    <TD nowrap valign=top>&nbsp;</TD>
    <TD nowrap valign=top> <FONT face="serif">(b)</FONT>&nbsp; &nbsp; &nbsp; </TD>
    <TD colspan=1> <FONT face="serif">The Company's Annual Report on Form 10-
      K for its fiscal year ended December 31, 2003, filed with the Commission
      on March 30, 2004 (Commission File No. <font face="serif">001-14207), and
      as subsequently amended;</font> </FONT> </TD>
  </TR>
  <TR>
    <TD colspan=3>&nbsp;</TD>
  </TR>
  <TR>
    <TD nowrap valign=top>&nbsp;</TD>
    <TD nowrap valign=top> <FONT face="serif">(c)</FONT>&nbsp; &nbsp; &nbsp; </TD>
    <TD colspan=1> <FONT face="serif">The Company's Quarterly Report on Form 10-Q
      for its fiscal quarter ended March 31, 2004, filed with the Commission on
      May 17, 2004 (Commission File No. 001-14207);</FONT> </TD>
  </TR>
  <TR>
    <TD colspan=3>&nbsp;</TD>
  </TR>
  <TR>
    <TD nowrap valign=top>&nbsp;</TD>
    <TD nowrap valign=top> <FONT face="serif">(d)</FONT>&nbsp; &nbsp; &nbsp; </TD>
    <TD colspan=1> <FONT face="serif">The Company's Current Reports on Form 8-K,
      filed with the Commission on January 14, 2004, February 24, 2004, March
      29, 2004, and June 16, 2004 (Commission File No. 001-14207); and</FONT>
    </TD>
  </TR>
  <TR>
    <TD colspan=3>&nbsp;</TD>
  </TR>
  <TR>
    <TD nowrap valign=top>&nbsp;</TD>
    <TD nowrap valign=top> <FONT face="serif">(e)</FONT>&nbsp; &nbsp; &nbsp; </TD>
    <TD colspan=1> <FONT face="serif">The description of the Company's Common
      Stock contained in the Company's Registration Statements on Form 8- A, filed
      with the Commission on August 27, 1993 and June 8, 1998 (Commission File
      Nos. 000-22332 and 000-14207, respectively), and any other amendment or
      report filed for the purpose of updating such description.</FONT> </TD>
  </TR>
  <TR>
    <TD colspan=3>&nbsp;</TD>
  </TR>
</TABLE>
<P>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">All documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), prior to the filing of a
post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold shall be deemed to be incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing of such documents. Any statement contained herein or in a document, all or a portion of which is incorporated or deemed to be incorporated by reference herein, shall be deemed to be modified or superseded for purposes
of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so
modified or superseded shall not be deemed, except as so modified or amended, to constitute a part of this Registration Statement. </FONT></P>
<P>
<B><FONT face="serif">Item 5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Interests of Named Experts and Counsel </FONT></B></P>
<P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<FONT face="serif">Not applicable.</FONT></P>
<P>
<B><FONT face="serif">Item 8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exhibits</FONT></B><FONT face="serif"> </FONT></P>
<P align="center">
<div align="center">
  <TABLE>
    <TR>
      <TD nowrap> <FONT size=2 face="serif">3</FONT><BR> </TD>
    </TR>
  </TABLE></P>
  </div>
<HR noshade align="center" width="100%" size=2>
<PAGE>


<A name="page_5"></A>

<P align="center"> <FONT face="serif">See the attached Exhibit Index at page 7,
  which is incorporated herein by reference.</FONT></P>
<P align="center">
<div align="center">
  <TABLE>
    <TR>
      <TD nowrap> <FONT size=2 face="serif">4</FONT><BR> </TD>
    </TR>
  </TABLE></P>
  </div>
<HR noshade align="center" width="100%" size=2>
<PAGE>


<A name="page_6"></A>

<P align="center">
<TABLE align="center"><TR><TD nowrap>
<B><FONT face="serif">SIGNATURES</FONT></B><BR>
</TD></TR></TABLE>
</P>
<P> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">Pursuant to the requirements
  of the Securities Act, the registrant certifies that it has reasonable grounds
  to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the
  undersigned, thereunto duly authorized, in the City of Alameda, State of California,
  on July 2, 2004. </FONT></P>
<P align="right">
<TABLE border=0 align="center" cellpadding=0 cellspacing=0 width="100%">
  <TR>
    <TD width = 50%>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD colspan="2"> </TD>
  </TR>
  <TR valign="bottom">
    <TD width="50%" align=left nowrap>&nbsp;</TD>
    <TD nowrap colspan=2 align=left> <FONT face="serif">INSITE VISION INCORPORATED</FONT>&nbsp;
    </TD>
  </TR>
  <TR>
    <TD width="50%">&nbsp;</TD>
    <TD colspan = 2>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD width="50%" align=left nowrap>&nbsp;</TD>
    <TD nowrap colspan=2 align=left> <FONT face="serif">By:</FONT>&nbsp; /s/ <i>S.
      Kumar Chandrasekaran, Ph.D.</i></FONT></TD>
  </TR>
  <TR valign="bottom">
    <TD align=left nowrap>&nbsp;</TD>
    <TD width="3%" colspan=1 align=left nowrap>&nbsp;</TD>
    <TD width="47%" align=left nowrap><hr size="1" noshade></TD>
  </TR>
  <TR valign="bottom">
    <TD width="50%" align=left nowrap>&nbsp;</TD>
    <TD nowrap colspan=2 align=left> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<FONT face="serif">S.
      Kumar Chandrasekaran, Ph.D.</FONT>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD width="50%" align=left nowrap>&nbsp;</TD>
    <TD nowrap colspan=2 align=left> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<FONT face="serif">Chairman
      of the Board, President, Chief</FONT>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD width="50%" align=left nowrap>&nbsp;</TD>
    <TD nowrap colspan=2 align=left> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<FONT face="serif">Executive
      Officer and Chief Financial Officer</FONT>&nbsp; </TD>
  </TR>
</TABLE>
<BR>
</P>
<P align="center">
<TABLE align="center"><TR><TD nowrap>
<B><FONT face="serif">POWER OF ATTORNEY</FONT></B><BR>
</TD></TR></TABLE>
</P>
<P>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">Each person whose signature appears below constitutes and appoints S. Kumar Chandrasekaran, Ph.D. as his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution,
for him and in his name, place, and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments, exhibits thereto and other documents in connection therewith) to this Registration Statement, and to file the
same, with all exhibits thereto, and other documents in connection therewith, with the Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be
done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done
by virtue hereof. </FONT></P>
<P>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT face="serif">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated. </FONT></P>
<TABLE width="100%" border=0 cellpadding=0 cellspacing=0>
  <TR>
    <TD width = 33%> </TD>
    <TD width = 0%> </TD>
    <TD width = 33%> </TD>
    <TD width = 0%> </TD>
    <TD width = 33%> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=center> <U><FONT face="serif">Signature</FONT></U>&nbsp;
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=center> <U><FONT face="serif">Title</FONT></U>&nbsp;
    </TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap colspan=1 align=center> <U><FONT face="serif">Date</FONT></U>&nbsp;
    </TD>
  </TR>
  <TR>
    <TD colspan = 5>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left><div align="center"><FONT face="serif">/s/
        <i>S. Kumar Chandrasekaran, Ph.D.</i></FONT> </div></TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD nowrap colspan=1 align=left> &nbsp; &nbsp;<FONT face="serif">Chairman
      of the Board,</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=center> <FONT face="serif">July 2, 2004</FONT>&nbsp;
    </TD>
  </TR>
  <TR>
    <TD colspan =1> <HR noshade size=1> </TD>
    <TD> </TD>
    <TD colspan=1 align=left valign="bottom" nowrap> &nbsp; &nbsp;<FONT face="serif">President,
      Chief Executive</FONT>&nbsp; </TD>
    <TD> </TD>
    <TD colspan =1> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=center> <FONT face="serif">S. Kumar Chandrasekaran,
      Ph.D.</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD colspan=1 align=left nowrap> &nbsp; &nbsp;<FONT face="serif">Officer and
      Chief Financial</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD colspan=1 align=left nowrap> &nbsp; &nbsp;<FONT face="serif">Officer (Principal
      Executive</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD colspan=1 align=left nowrap> &nbsp; &nbsp;<FONT face="serif">Officer and
      Principal Financial</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD colspan=1 align=left nowrap> &nbsp; &nbsp;<FONT face="serif">and Accounting
      Officer)</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
  </TR>
</TABLE>
<BR>
<P align="center">
<div align="center">
  <TABLE>
    <TR>
      <TD nowrap> <FONT size=2 face="serif">5</FONT><BR> </TD>
    </TR>
  </TABLE></P>
  </div>
<HR noshade align="center" width="100%" size=2>
<PAGE>


<A name="page_7"></A>

<TABLE width="100%" border=0 cellpadding=0 cellspacing=0>
<TR>
	<TD width = 33%>
	</TD>
	<TD width = 2%>
	</TD>
	<TD width = 33% align="center">
	</TD>
	<TD width = 2%>
	</TD>
	<TD width = 33% align="center">
	</TD>
</TR>
<TR valign="bottom">
	<TD nowrap colspan=1 align=left><FONT face="serif">/s/
        <i>Mitchell H. Friedlander, M.D.</i></FONT>

	</TD>
	<TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>
<FONT face="serif">Director</FONT>&nbsp;
	</TD>
	<TD>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center> <FONT face="serif">July 2, 2004</FONT>&nbsp;
    </TD>
</TR>
<TR>
	<TD colspan =1>
<HR noshade size=1>
	</TD>
	<TD>
	</TD>
	<TD colspan =1 align="center">
	</TD>
	<TD>
	</TD>
	<TD colspan =1 align="center">
	</TD>
</TR>
<TR valign="bottom">
	<TD nowrap colspan=1 align=left>
<FONT face="serif">Mitchell H. Friedlander, M.D.</FONT>&nbsp;
	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>&nbsp;

	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>&nbsp;

	</TD>
</TR>
<TR>
	<TD colspan = 5>&nbsp;

	</TD>
</TR>
<TR valign="bottom">
	<TD nowrap colspan=1 align=left><FONT face="serif">/s/
        <i>John L. Mattana</i></font>

	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>
<FONT face="serif">Director</FONT>&nbsp;
	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center> <FONT face="serif">July 2, 2004</FONT>&nbsp;
    </TD>
</TR>
<TR>
	<TD colspan =1>
<HR noshade size=1>
	</TD>
	<TD>
	</TD>
	<TD colspan =1 align="center">
	</TD>
	<TD>
	</TD>
	<TD colspan =1 align="center">
	</TD>
</TR>
<TR valign="bottom">
	<TD nowrap colspan=1 align=left>
<FONT face="serif">John L. Mattana</FONT>&nbsp;
	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>&nbsp;

	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>&nbsp;

	</TD>
</TR>
<TR>
	<TD colspan = 5>&nbsp;

	</TD>
</TR>
<TR valign="bottom">
	<TD nowrap colspan=1 align=left><FONT face="serif">/s/
        <i>Jon S. Saxe, Esq.</i></font>

	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>
<FONT face="serif">Director</FONT>&nbsp;
	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center> <FONT face="serif">July 2, 2004</FONT>&nbsp;
    </TD>
</TR>
<TR>
	<TD colspan =1>
<HR noshade size=1>
	</TD>
	<TD>
	</TD>
	<TD colspan =1 align="center">
	</TD>
	<TD>
	</TD>
	<TD colspan =1 align="center">
	</TD>
</TR>
<TR valign="bottom">
	<TD nowrap colspan=1 align=left>
<FONT face="serif">Jon S. Saxe, Esq.</FONT>&nbsp;
	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>&nbsp;

	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>&nbsp;

	</TD>
</TR>
<TR>
	<TD height="20" colspan = 5>&nbsp;

	</TD>
</TR>
<TR valign="bottom">
	<TD nowrap colspan=1 align=left><FONT face="serif">/s/
        <i>Anders P. Wiklund</i></font>

	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>
<FONT face="serif">Director</FONT>&nbsp;
	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center> <FONT face="serif">July 2, 2004</FONT>&nbsp;
    </TD>
</TR>
<TR>
	<TD colspan =1>
<HR noshade size=1>
	</TD>
	<TD>
	</TD>
	<TD colspan =1 align="center">
	</TD>
	<TD>
	</TD>
	<TD colspan =1 align="center">
	</TD>
</TR>
<TR valign="bottom">
	<TD nowrap colspan=1 align=left>
<FONT face="serif">Anders P. Wiklund</FONT>&nbsp;
	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>&nbsp;

	</TD>
	<TD>&nbsp;
	</TD>
	<TD nowrap colspan=1 align=center>&nbsp;

	</TD>
</TR>
</TABLE><BR>
<P align="center">
<div align="center">
  <TABLE>
    <TR>
      <TD nowrap> <FONT size=2 face="serif">6</FONT><BR> </TD>
    </TR>
  </TABLE></P>
  </div>
<HR noshade align="center" width="100%" size=2>
<PAGE>


<A name="page_8"></A>

<P align="center">
<div align="center">
  <TABLE>
    <TR>
      <TD nowrap> <B><FONT face="serif">EXHIBIT INDEX</FONT></B><BR> </TD>
    </TR>
  </TABLE></P>
  </div>
<TABLE width="100%" border=0 cellpadding=0 cellspacing=0>
  <TR>
    <TD width = 10%> </TD>
    <TD width = 0%> </TD>
    <TD width = 90%> </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT face="serif">Exhibit</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <U><FONT face="serif">Number</FONT></U>&nbsp;
    </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;
      &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<U><FONT face="serif">Description
      of Exhibit</FONT></U>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT face="serif">4.1</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> &nbsp; &nbsp; &nbsp; &nbsp;<FONT face="serif">InSite
      Vision Incorporated 1994 Stock Option Plan.</FONT>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
  </TR>
  <TR valign="bottom" bgcolor="#CCFFFF">
    <TD colspan=1 align=left nowrap> <FONT face="serif">4.2</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD colspan=1 align=left nowrap> &nbsp; &nbsp; &nbsp; &nbsp;<FONT face="serif">InSite
      Vision Incorporated 1994 Employee Stock Purchase Plan.</FONT>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT face="serif">5</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> &nbsp; &nbsp; &nbsp; &nbsp;<FONT face="serif">Opinion
      of O'Melveny &amp; Myers LLP (opinion re legality).</FONT>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
  </TR>
  <TR valign="bottom" bgcolor="#CCFFFF">
    <TD colspan=1 align=left nowrap> <FONT face="serif">23.1</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD colspan=1 align=left nowrap> &nbsp; &nbsp; &nbsp; &nbsp;<FONT face="serif">Consent
      of Burr, Pilger &amp; Mayer LLP.</FONT>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left> <FONT face="serif">23.2</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD nowrap colspan=1 align=left> &nbsp; &nbsp; &nbsp; &nbsp;<FONT face="serif">Consent
      of Ernst &amp; Young LLP.</FONT>&nbsp; </TD>
  </TR>
  <TR valign="bottom">
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap colspan=1 align=left>&nbsp;</TD>
  </TR>
  <TR valign="bottom" bgcolor="#CCFFFF">
    <TD colspan=1 align=left nowrap> <FONT face="serif">24</FONT>&nbsp; </TD>
    <TD>&nbsp; </TD>
    <TD colspan=1 align=left nowrap> &nbsp; &nbsp; &nbsp; &nbsp;<FONT face="serif">Power
      of Attorney (included in this Registration Statement under "Signatures").</FONT>&nbsp;
    </TD>
  </TR>
</TABLE>
<BR>
<P align="center">
<div align="center">
  <TABLE>
    <TR>
      <TD nowrap> <FONT size=2 face="serif">7</FONT><BR> </TD>
    </TR>
  </TABLE></P>
  </div>
<HR noshade align="center" width="100%" size=2>
</BODY>
</HTML>
[{"type": "S-8", "sequence": "1", "filename": "v04306_s8.htm", "secsgml_size_bytes": 38645}]
{"company-data": {"conformed-name": "INSITE VISION INC", "cik": "0000802724", "assigned-sic": "2834", "irs-number": "943015807", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-117193", "film-number": "04904085"}, "business-address": {"street1": "965 ATLANTIC AVE", "street2": "--", "city": "ALAMEDA", "state": "CA", "zip": "94501", "phone": "5108658800"}, "mail-address": {"street1": "965 ATLANTIC AVE", "street2": "---", "city": "ALAMEDA", "state": "CA", "zip": "94501"}}
EDGARized at Vintage Filings, LLC
As filed with the Securities and Exchange Commission
      on July 6, 2004
Registration No. __________________
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
___________________
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
___________________
INSITE VISION INCORPORATED
(Exact Name of Registrant as Specified in Its Charter)
___________________
Delaware
94-3015807
(State or Other
      Jurisdiction of
(I.R.S.
        Employer
Incorporation
      or Organization)
Identification
        No.)
965 Atlantic Avenue
Alameda, California 94501
(Address, Including Zip Code, of Principal Executive Offices)
___________________
InSite
  Vision Incorporated 1994 Stock Option Plan
InSite Vision Incorporated 1994 Employee Stock Purchase Plan
(Full Title of the Plan(s))
___________________
S. Kumar Chandrasekaran, Ph.D.
Chief Executive Officer
InSite Vision Incorporated
965 Atlantic Avenue
Alameda, California 94501
(510) 865-8800
(Name, Address and Telephone Number, Including Area Code, of Agent For Service)
COPY TO:
Timothy
      R. Curry, Esq.
O'Melveny &
      Myers LLP
2765 Sand Hill Road
Menlo Park, California 94025
(650) 473-2600
___________________
CALCULATION
      OF REGISTRATION FEE
Proposed
Title Of
Amount
Proposed
Maximum
Amount Of
Securities
To Be
Maximum Offering
Aggregate
Registration
To Be Registered
Registered
Price Per Share
Offering Price
Fee
Common Stock,
$0.01
      par value,
1,586,123
(1)
$0.67
(2)
$1,062,702.41
(2)
$
134.64
(2)
issuable under
      the
shares
1994 Stock Option
Plan
Common
      Stock,
$0.01
      par value,
350,000
(1)
$0.67
(2)
$234,500.00
(2)
$29.71
(2)
issuable
      under the
shares
1994
      Employee
Stock
      Purchase
Plan
Totals
1,936,123
$0.67
(2)
$1,297,202.41
(2)
164.35
(2)
shares
(1)
This Registration Statement covers, in addition to the number of shares of InSite Vision Incorporated, a Delaware corporation (the "Company") common stock, par value $0.01 per share (the "Common Stock"), stated above,
options and other rights to purchase or acquire the shares of Common Stock covered by this Registration Statement and, pursuant to Rule 416(c) under the Securities Act of 1933, as amended (the "Securities Act"), an additional indeterminate number of
shares, options and rights that may be offered or issued pursuant to the InSite Vision Incorporated 1994 Stock Option Plan and the InSite Vision Incorporated 1994 Employee Stock Purchase Plan (together, the "Plans"), as a result of one or more
adjustments under the Plans to prevent dilution resulting from one or more stock splits, stock dividends or similar transactions.
(2)
Pursuant to Rule 457(h), the maximum offering price, per share and in the aggregate, and the registration fee were calculated based upon the average of the high and low prices of the Common Stock on June 29, 2004, as
reported by the American Stock Exchange.
The Exhibit Index for this Registration Statement is at page 7.
EXPLANATORY NOTE
This Registration
  Statement is filed by the Company to register additional securities issuable
  pursuant to the Plans and consists of only those items required by General Instruction
  E to Form S-8.
_________________________
PART I
INFORMATION REQUIRED IN THE
SECTION 10(a) PROSPECTUS
The document(s) containing the information specified in Part I of Form S-8 (plan information and registrant information) will be sent or given to employees as specified by Securities Act Rule
428(b)(1). Such documents need not be filed with the Securities and Exchange Commission (the "Commission") either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Securities Act Rule 424. These
documents, which include the statement of availability required by Item 2 of Form S-8, and the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Form S-8 (Part II hereof), taken together, constitute a
prospectus that meets the requirements of Section 10(a) of the Securities Act.
2
PART II
INFORMATION REQUIRED
          IN THE
REGISTRATION STATEMENT
Item 3.     Incorporation of Certain Documents by Reference
The following documents of the Company filed with the Commission are incorporated herein by reference:
(a)
The Company's Registration Statements on
      Form S-8, filed with the Commission on October 23, 2001, August 11, 2000,
      June 2, 1999, July 28, 1998, and June 23, 1997 (Commission File Nos. 333-72098,
      333-43504, 333-79789, 333-60057, and 333-29801, respectively);
(b)
The Company's Annual Report on Form 10-
      K for its fiscal year ended December 31, 2003, filed with the Commission
      on March 30, 2004 (Commission File No.
001-14207), and
      as subsequently amended;
(c)
The Company's Quarterly Report on Form 10-Q
      for its fiscal quarter ended March 31, 2004, filed with the Commission on
      May 17, 2004 (Commission File No. 001-14207);
(d)
The Company's Current Reports on Form 8-K,
      filed with the Commission on January 14, 2004, February 24, 2004, March
      29, 2004, and June 16, 2004 (Commission File No. 001-14207); and
(e)
The description of the Company's Common
      Stock contained in the Company's Registration Statements on Form 8- A, filed
      with the Commission on August 27, 1993 and June 8, 1998 (Commission File
      Nos. 000-22332 and 000-14207, respectively), and any other amendment or
      report filed for the purpose of updating such description.
All documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), prior to the filing of a
post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold shall be deemed to be incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing of such documents. Any statement contained herein or in a document, all or a portion of which is incorporated or deemed to be incorporated by reference herein, shall be deemed to be modified or superseded for purposes
of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so
modified or superseded shall not be deemed, except as so modified or amended, to constitute a part of this Registration Statement.
Item 5.     Interests of Named Experts and Counsel
Not applicable.
Item 8.     Exhibits
3
See the attached Exhibit Index at page 7,
  which is incorporated herein by reference.
4
SIGNATURES
Pursuant to the requirements
  of the Securities Act, the registrant certifies that it has reasonable grounds
  to believe that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its behalf by the
  undersigned, thereunto duly authorized, in the City of Alameda, State of California,
  on July 2, 2004.
INSITE VISION INCORPORATED
By:
/s/
S.
      Kumar Chandrasekaran, Ph.D.
S.
      Kumar Chandrasekaran, Ph.D.
Chairman
      of the Board, President, Chief
Executive
      Officer and Chief Financial Officer
POWER OF ATTORNEY
Each person whose signature appears below constitutes and appoints S. Kumar Chandrasekaran, Ph.D. as his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution,
for him and in his name, place, and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments, exhibits thereto and other documents in connection therewith) to this Registration Statement, and to file the
same, with all exhibits thereto, and other documents in connection therewith, with the Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be
done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done
by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/
S. Kumar Chandrasekaran, Ph.D.
Chairman
      of the Board,
July 2, 2004
President,
      Chief Executive
S. Kumar Chandrasekaran,
      Ph.D.
Officer and
      Chief Financial
Officer (Principal
      Executive
Officer and
      Principal Financial
and Accounting
      Officer)
5
/s/
Mitchell H. Friedlander, M.D.
Director
July 2, 2004
Mitchell H. Friedlander, M.D.
/s/
John L. Mattana
Director
July 2, 2004
John L. Mattana
/s/
Jon S. Saxe, Esq.
Director
July 2, 2004
Jon S. Saxe, Esq.
/s/
Anders P. Wiklund
Director
July 2, 2004
Anders P. Wiklund
6
EXHIBIT INDEX
Exhibit
Number
Description
      of Exhibit
4.1
InSite
      Vision Incorporated 1994 Stock Option Plan.
4.2
InSite
      Vision Incorporated 1994 Employee Stock Purchase Plan.
5
Opinion
      of O'Melveny & Myers LLP (opinion re legality).
23.1
Consent
      of Burr, Pilger & Mayer LLP.
23.2
Consent
      of Ernst & Young LLP.
24
Power
      of Attorney (included in this Registration Statement under "Signatures").
7