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  <div style="text-align: center;"><font style="font-weight: bold;">As filed with the Securities and Exchange Commission on June 21, 20<a name="Registration_Statement_Body"></a>21</font></div>
  <div style="text-align: right;"><font style="font-weight: bold;">Registration No. 333-</font></div>
  <div>
    <div>
      <div style="text-align: center; font-size: 14pt; font-weight: bold;">
        <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;">UNITED STATES</div>
      <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div>&#160;</div>
      <div style="text-align: center; font-weight: bold;">
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
      <div style="text-align: center; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div>&#160;</div>
      <div style="text-align: center; font-weight: bold;">
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
      <div style="text-align: center; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; font-size: 24pt; font-weight: bold;">NANOBIOTIX S.A.</div>
      <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z3896eb9a3d614b32ace60b305752da91">

          <tr>
            <td style="width: 49%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"> <br>
              </div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">France</div>
            </td>
            <td style="width: 2%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 49%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Not applicable</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: bottom;">&#160;</td>
            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 49%; vertical-align: bottom;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: bottom;">
              <div style="text-align: center; font-weight: bold;">(State or other jurisdiction of incorporation or organization)</div>
            </td>
            <td style="width: 2%; vertical-align: top;"><br>
            </td>
            <td style="width: 49%; vertical-align: bottom;">
              <div style="text-align: center; font-weight: bold;">(I.R.S. employer identification No.)</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div style="text-align: center; font-weight: bold;">60, rue de Wattignies</div>
      <div style="text-align: center; font-weight: bold;">75012 Paris, France</div>
      <div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Address of Principal Executive Offices)(Zip Code)</div>
      </div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">BSA Plan</div>
      <div style="text-align: center; font-weight: bold;">Free Share Plan</div>
      <div style="text-align: center; font-weight: bold;">2021 Stock Option Plan</div>
      <div style="text-align: center; font-weight: bold;">&#160;(Full title of the plans)</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Nanobiotix Corporation</div>
      <div style="text-align: center; font-weight: bold;">Attn: Bart Van Rhijn</div>
      <div style="text-align: center; font-weight: bold;">210 Broadway</div>
      <div style="text-align: center; font-weight: bold;">Cambridge, Massachusetts</div>
      <div style="text-align: center; font-weight: bold;">+1 617 712 1568</div>
      <div style="text-align: center; font-weight: bold;">(Name and address of agent for service) (Telephone number, including area code, of agent for service)</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zed1dbb60dd8c45e0b3d09e42a118da94">

          <tr>
            <td colspan="4" style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-style: italic;"> <br>
              </div>
              <div style="text-align: center; font-style: italic;">Copies to:</div>
            </td>
          </tr>
          <tr>
            <td style="width: 27.71%; vertical-align: bottom;">
              <div style="text-align: center; font-weight: bold;">Peter E. Devlin</div>
              <div style="text-align: center; font-weight: bold;">Robert G. Marshall II</div>
              <div style="text-align: center; font-weight: bold;">Jones Day</div>
              <div style="text-align: center; font-weight: bold;">250 Vesey Street</div>
              <div style="text-align: center; font-weight: bold;">New York, New York 10281</div>
              <div style="text-align: center; font-weight: bold;">+1 212 262 3939</div>
            </td>
            <td style="width: 27.88%; vertical-align: bottom;">&#160;</td>
            <td style="width: 24.94%; vertical-align: bottom;">&#160;</td>
            <td style="width: 19.47%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Renaud Bonnet</div>
              <div style="text-align: center; font-weight: bold;">Jean-Gabriel Griboul</div>
              <div style="text-align: center; font-weight: bold;">Jones Day</div>
              <div style="text-align: center; font-weight: bold;">2 rue Saint-Florentin</div>
              <div style="text-align: center; font-weight: bold;">75001 Paris, France</div>
              <div style="text-align: center; font-weight: bold;">+33 1 56 59 39 39</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
        filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zea9d1f2598fb41ceb6f69f8cc4ef4537">

          <tr>
            <td style="width: 21.48%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Large accelerated filer</div>
            </td>
            <td style="width: 6.64%; vertical-align: top; text-align: center;">&#9744;</td>
            <td style="width: 39.84%; vertical-align: top;">&#160;</td>
            <td style="width: 25.39%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Accelerated filer</div>
            </td>
            <td style="width: 6.64%; vertical-align: bottom; text-align: center;">&#9744;</td>
          </tr>
          <tr>
            <td style="width: 21.48%; vertical-align: top;">&#160;</td>
            <td style="width: 6.64%; vertical-align: bottom;">&#160;</td>
            <td style="width: 39.84%; vertical-align: top;">&#160;</td>
            <td style="width: 25.39%; vertical-align: top;">&#160;</td>
            <td style="width: 6.64%; vertical-align: bottom; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 21.48%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Non-accelerated filer</div>
            </td>
            <td style="width: 6.64%; vertical-align: bottom; text-align: center;">&#9746;</td>
            <td style="width: 39.84%; vertical-align: top;">&#160;</td>
            <td style="width: 25.39%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Smaller reporting company</div>
            </td>
            <td style="width: 6.64%; vertical-align: bottom; text-align: center;">&#9744;</td>
          </tr>
          <tr>
            <td style="width: 21.48%; vertical-align: top;">&#160;</td>
            <td style="width: 6.64%; vertical-align: bottom;">&#160;</td>
            <td style="width: 39.84%; vertical-align: top;">&#160;</td>
            <td style="width: 25.39%; vertical-align: top;">&#160;</td>
            <td style="width: 6.64%; vertical-align: bottom; text-align: center;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 21.48%; vertical-align: top;">&#160;</td>
            <td style="width: 6.64%; vertical-align: bottom;">&#160;</td>
            <td style="width: 39.84%; vertical-align: top;">&#160;</td>
            <td style="width: 25.39%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Emerging growth company</div>
            </td>
            <td style="width: 6.64%; vertical-align: bottom; text-align: center;">&#9746;</td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z75db5a1f4ef648f1b6945abdabfc20e8">

          <tr>
            <td style="width: 93.36%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided
                pursuant to Section 7(a)(2)(B) of the Securities Act.</div>
            </td>
            <td style="width: 6.64%; vertical-align: bottom; text-align: center;">&#9744;</td>
          </tr>

      </table>
      <div>&#160;</div>
      <div style="text-align: center; font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z00c88dbdcf874a60ac87a7a996130f69">

          <tr>
            <td rowspan="1" style="width: 40.89%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td rowspan="1" style="width: 0.76%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td rowspan="1" style="width: 13.1%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td rowspan="1" style="width: 0.76%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td rowspan="1" style="width: 13.1%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td rowspan="1" style="width: 0.76%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td rowspan="1" style="width: 15.44%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td rowspan="1" style="width: 0.76%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td rowspan="1" style="width: 14.46%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
          </tr>
          <tr>
            <td style="width: 40.89%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Title of Securities</div>
              <div style="text-align: center; font-weight: bold;">to be Registered <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 13.1%; vertical-align: bottom; border-left: 2px double rgb(0, 0, 0); border-bottom: 2px double rgb(0, 0, 0);">
              <div style="text-align: center;">Amount</div>
              <div style="text-align: center;">to be</div>
              <div style="text-align: center;">Registered <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2) (3)</sup></div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 13.1%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">Proposed</div>
              <div style="text-align: center;">Maximum</div>
              <div style="text-align: center;">Offering Price</div>
              <div style="text-align: center;">per Share</div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 15.44%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">Proposed</div>
              <div style="text-align: center;">Maximum</div>
              <div style="text-align: center;">Aggregate</div>
              <div style="text-align: center;">Offering Price</div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 14.46%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">Amount of</div>
              <div style="text-align: center;">Registration Fee</div>
            </td>
          </tr>
          <tr>
            <td style="width: 40.89%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Ordinary shares, &#8364;0.03 nominal value per share, reserved for future issuance upon the exercise of share options (<font style="font-style: italic;">options de souscription d&#8217;actions</font> or &#8220;<font style="font-weight: bold; font-style: italic;">OSA</font>&#8221;) issuable under the 2021 Stock Option Plan</div>
            </td>
            <td style="width: 0.76%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 13.1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); border-left: 2px double rgb(0, 0, 0);">
              <div style="text-align: center;">850,000</div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 13.1%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">
                <div>
                  <div style="color: rgb(0, 0, 0);">$14.52<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></div>
                </div>
              </div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 15.44%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">
                <div style="color: rgb(0, 0, 0);">
                  <div>
                    <div style="color: rgb(0, 0, 0);">$12,342,000</div>
                  </div>
                </div>
              </div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 14.46%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">
                <div style="color: rgb(0, 0, 0);">
                  <div>
                    <div style="color: rgb(0, 0, 0);">$1,346.51</div>
                  </div>
                </div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 40.89%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">Ordinary shares, &#8364;0.03 nominal value per share, reserved for future issuance upon the exercise of share warrants (<font style="font-style: italic;">bons de souscription d&#8217;actions</font> or &#8220;<font style="font-weight: bold; font-style: italic;">BSA</font>&#8221;) issuable under the BSA Plan</div>
            </td>
            <td style="width: 0.76%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 13.1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-left: 2px double rgb(0, 0, 0);">
              <div style="text-align: center;">850,000</div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 13.1%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">
                <div>
                  <div>
                    <div>
                      <div style="color: rgb(0, 0, 0);">$14.52<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></div>
                    </div>
                  </div>
                </div>
              </div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 15.44%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">
                <div>
                  <div>
                    <div style="color: rgb(0, 0, 0);">
                      <div>
                        <div style="color: rgb(0, 0, 0);">$12,342,000</div>
                      </div>
                    </div>
                  </div>
                </div>
              </div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            <td style="width: 14.46%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center;">
                <div>
                  <div>
                    <div>
                      <div>
                        <div style="color: rgb(0, 0, 0);">
                          <div>
                            <div style="color: rgb(0, 0, 0);">$1,346.51</div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 40.89%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
              <div style="color: rgb(0, 0, 0);">Ordinary shares, &#8364;0.03 nominal value per share, reserved for future issuance upon settlement of free shares (a<font style="font-style: italic;">ttributions gratuites d&#8217;actions</font> or &#8220;<font style="font-weight: bold;">AGA</font>&#8221;) under the Free Share Plan.</div>
            </td>
            <td style="width: 0.76%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 13.1%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255); border-left: 2px double rgb(0, 0, 0);">
              <div style="text-align: center;">850,000</div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 13.1%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">
                <div>
                  <div>
                    <div>
                      <div style="color: rgb(0, 0, 0);">$14.52<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup></div>
                    </div>
                  </div>
                </div>
              </div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 15.44%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">
                <div>
                  <div>
                    <div style="color: rgb(0, 0, 0);">
                      <div>
                        <div style="color: rgb(0, 0, 0);">$12,342,000</div>
                      </div>
                    </div>
                  </div>
                </div>
              </div>
            </td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 14.46%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(204, 238, 255);">
              <div style="text-align: center;">
                <div>
                  <div>
                    <div>
                      <div>
                        <div style="color: rgb(0, 0, 0);">
                          <div>
                            <div style="color: rgb(0, 0, 0);">$1,346.51</div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 40.89%; vertical-align: top; border-bottom: 4px double rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Aggregate Registration Fee</div>
            </td>
            <td style="width: 0.76%; vertical-align: top; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td style="width: 13.1%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0); border-left: 2px double rgb(0, 0, 0);">&#160;</td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td style="width: 13.1%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td style="width: 15.44%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td style="width: 0.76%; vertical-align: bottom; border-bottom: 4px double rgb(0, 0, 0);">&#160;</td>
            <td style="width: 14.46%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 4px double rgb(0, 0, 0); text-align: center;">
              <div>
                <div style="color: rgb(0, 0, 0);">
                  <div>
                    <div style="color: rgb(0, 0, 0);">$4,039.53</div>
                  </div>
                </div>
              </div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="za3ea362470a645a3a8da96990a8f54bb">

          <tr>
            <td style="width: 10pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">(1)</td>
            <td style="width: auto; vertical-align: top;">
              <div>These shares may be represented by American Depositary Shares, or ADSs, of Nanobiotix S.A. (the &#8220;<font style="font-weight: bold; font-style: italic;">Registrant</font>&#8221;). Each ADS represents one ordinary share of the Registrant. The
                Registrant&#8217;s ADSs issuable upon deposit of the ordinary shares registered hereby have been registered pursuant to a separate registration statement on Form F-6 (File No. 333-250880).</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z752dcebff755458f9256fb921dc0a615">

          <tr>
            <td style="width: 10pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">(2)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Securities Act</font>&#8221;), this Registration Statement shall also cover any additional ordinary shares of the
                Registrant that may become issuable under any of the plans identified on the cover of this Registration Statement by reason of any share dividend, share split, recapitalization or other similar transaction effected without receipt of
                consideration that increases the number of the Registrant's outstanding ordinary shares.</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zaab4d4e9586a42d98f3c72a7a22e3ffa">

          <tr>
            <td style="width: 10pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">(3)</td>
            <td style="width: auto; vertical-align: top;">
              <div>The shareholders authorization relating to the ordinary shares reserved for future issuance upon OSA, BSA and AGA grants covered by this Registration Statement further restricts the aggregate number of ordinary shares issuable to an
                aggregate of 850,000 ordinary shares.&#160; Accordingly, notwithstanding the 2,550,000 ordinary shares registered on this Registration Statement, the aggregate amount issuable upon such future issuances cannot exceed 850,000 ordinary shares.</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb825f635119c41229b57512367ef02c9">

          <tr>
            <td style="width: 10pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">(4)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act based upon the price of $14.52 per ADS, which was the average of the high and low prices
                of the ADSs as reported on Nasdaq Global Select Market for June 18, 2021.</div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
      <div>
        <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: center; font-weight: bold;">PART I</div>
      <div>&#160;</div>
      <div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>
      </div>
      <div>&#160;</div>
      <div style="text-indent: 36pt;">The information specified in Part I of Form S-8 is omitted from this Registration Statement in accordance with the provisions of Rule 428 under the Securities Act and the introductory note to Part I of Form S-8. The
        documents containing the information specified in Part I of Form S-8 will be delivered to the participants in the plans covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities Act.</div>
      <div>&#160;</div>
      <div style="text-align: center; font-weight: bold;">PART II</div>
      <div>&#160;</div>
      <div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
      </div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z0da821beb1704caaabda378d2c329238">

          <tr>
            <td style="width: 45pt; vertical-align: top; font-weight: bold;">ITEM 3.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">INCORPORATION OF DOCUMENTS BY REFERENCE</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">The following documents filed by Nanobiotix S.A. (the &#8220;<font style="font-weight: bold; font-style: italic;">Registrant</font>&#8221;) with the U.S. Securities and Exchange Commission (the &#8220;<font style="font-weight: bold; font-style: italic;">Commission</font>&#8221;) are incorporated by reference into this Registration Statement:</div>
      <div style="text-align: justify; text-indent: 36pt;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="font-weight: bold;">(a)</font>&#160;&#160; the Registrant&#8217;s Annual Report on Form 20-F/A (File No. 001-39777) for the year ended <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1760854/000162828021006685/nbx-20201231.htm">December 31, 2020</a>, filed with the Commission pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Exchange Act</font>&#8221;) on April 8, 2021, which contains audited financial statements for the Registrant&#8217;s latest fiscal year for which such statements have been filed;</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="font-weight: bold;">(b)</font>&#160; The Registrant&#8217;s Reports on Form 6-K (File No. 001-39777) furnished to the Commission on <a href="https://www.sec.gov/Archives/edgar/data/0001760854/000115752321000456/a52411813.htm">April 14, 2021</a> (including Exhibit 99.1), <a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036121014773/brhc10023764_6k.htm">April 28,
          2021</a> (including Exhibit 99.1), <a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036121015025/brhc10023853_6k.htm">April 29, 2021</a> (including Exhibit 99.1), <a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036121016832/brhc10024432_6k.htm">May 11, 2021</a> (including Exhibit 99.1), <a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036121018068/nt10024835x1_6k.htm">May
          19, 2021</a> (including Exhibit 99.1), <a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036121018434/brhc10025015_6k.htm">May 21, 2021</a> (including Exhibit 99.1), <a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036121018691/brhc10025123_6k.htm">May 25, 2021</a> (including Exhibit 99.1), <a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036121019439/brhc10025363_6k.htm">June
          1, 2021</a> (including Exhibit 99.1), and <a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036121019853/brhc10025498_6k.htm">June 4, 2021</a> (including Exhibit 99.1), and all other reports on Form 6-K that are furnished to the
        Commission and that are identified in such form as being incorporated by reference, since the end of the fiscal year covered by the Registrant&#8217;s annual report on Form 20-F/A referred to in (a) above; and</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="font-weight: bold;">(e)</font>&#160;&#160; the descriptions of the Registrant&#8217;s American Depositary Shares and Ordinary Shares contained in the Registrant&#8217;s Registration Statement on Form 8-A
        filed with the Commission on <a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036120027625/nt1009390x10_8a12b.htm">December 8, 2020</a> (File No. 001-39777) under the Securities Exchange Act of 1934, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Exchange Act</font>&#8221;), including any amendment or report filed for the purpose of updating such description.</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">All other reports and documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration Statement and
        prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered hereby have been sold or which deregisters all such securities then remaining unsold, shall be deemed to be incorporated by
        reference herein and to be a part of this Registration Statement from the date of filing of such reports and documents. Any statement contained in this Registration Statement, in an amendment hereto or in a document incorporated or deemed to be
        incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed amendment to this Registration Statement or in
        any document that also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this
        Registration Statement.</div>
      <div>&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; text-indent: 36pt;">Information subsequently furnished on Form 6-K shall not be deemed incorporated herein by reference unless such Form 6-K expressly provides to the contrary.</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z9858acd0acc4435c83a718b6ed3fbc12">

          <tr>
            <td style="width: 45pt; vertical-align: top; font-weight: bold;">ITEM 4.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">DESCRIPTION OF SECURITIES</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div>Not applicable.</div>
      <div> <br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zc1609b621faf4cf782772c6ef1215a0d">

          <tr>
            <td style="width: 45pt; vertical-align: top; font-weight: bold;">ITEM 5.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">INTERESTS OF NAMED EXPERTS AND COUNSEL</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div>Not applicable.</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z00794d24f86243e9ba84afb86c059f10">

          <tr>
            <td style="width: 45pt; vertical-align: top; font-weight: bold;">ITEM 6.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">INDEMNIFICATION OF DIRECTORS AND OFFICERS</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">Under French law, provisions in the By-laws that limit the liability of directors and officers are ineffective. However, French law allows <font style="font-style: italic;">soci&#233;t&#233;s anonymes</font>
        to contract for and maintain liability insurance against civil liabilities incurred by any of their directors and officers involved in a third-party action, <font style="font-style: italic;">provided</font> that they acted in good faith and within
        their capacities as directors or officers of the company. Criminal liability cannot be indemnified under French law, whether directly by the company or through liability insurance. Such rules apply to executive and supervisory board members.</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">The Registrant has obtained and maintains customary liability insurance coverage for our supervisory board members and executive board members, including insurance against liability under the
        Securities Act.</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to the Registrant&#8217;s directors, officers and controlling persons, the Registrant has been advised that,
        in the opinion of the Commission, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z7a926700287d4332ac7d62bb804f62e1">

          <tr>
            <td style="width: 45pt; vertical-align: top; font-weight: bold;">ITEM 7.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">EXEMPTION FROM REGISTRATION CLAIMED.</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div>Not applicable.</div>
      <div> <br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb75262aff9e44da280cb9171985292d7">

          <tr>
            <td style="width: 45pt; vertical-align: top; font-weight: bold;">ITEM 8.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">EXHIBITS</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">The following exhibits are filed herewith:</div>
      <div>&#160;</div>
      <div>
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="za1c1110a7fee4416b6b37c0a708b2920">

            <tr>
              <td style="width: 10.89%; vertical-align: middle;">
                <div style="font-weight: bold;">Exhibit</div>
                <div style="font-weight: bold;">Number</div>
              </td>
              <td style="width: 89.11%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;">Description</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.89%; vertical-align: middle; background-color: rgb(204, 238, 255);">
                <div style="color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036120026217/nt10009390x7_ex3-1.htm">3.1</a></div>
              </td>
              <td style="width: 89.11%; vertical-align: middle; background-color: rgb(204, 238, 255);">
                <div><font style="color: #000000;">By-laws of the Registrant (English translation) (incorporated herein by reference to Exhibit 3.1 to the </font>Registrant&#8217;s Registration Statement on Form F-1 (File No. 333-250707))</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.89%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036120026217/nt10009390x7_ex4-1.htm">4.1</a></div>
              </td>
              <td style="width: 89.11%; vertical-align: middle;">
                <div><font style="color: #000000;">Form of Deposit Agreement by and among Nanobiotix S.A. and Citibank, N.A., as depositary, and the Holders and Beneficial Owners of American Depositary Shares issued thereunder (incorporated herein by
                    reference to Exhibit 4.1 to the </font>Registrant&#8217;s Registration Statement on Form F-1 (File No. 333-250707))</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.89%; vertical-align: middle; background-color: rgb(204, 238, 255);">
                <div style="color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/0001760854/000114036120026217/nt10009390x7_ex4-1.htm">4.2</a></div>
              </td>
              <td style="width: 89.11%; vertical-align: middle; background-color: rgb(204, 238, 255);">
                <div style="color: rgb(0, 0, 0);">Form of American Depositary Receipt (included in Exhibit 4.1)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.89%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);"><a href="brhc10025772_ex5-1.htm">5.1*</a></div>
              </td>
              <td style="width: 89.11%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);">Opinion of Jones Day</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.89%; vertical-align: middle; background-color: rgb(204, 238, 255);">
                <div style="color: rgb(0, 0, 0);"><a href="brhc10025772_ex23-1.htm">23.1*</a></div>
              </td>
              <td style="width: 89.11%; vertical-align: middle; background-color: rgb(204, 238, 255);">
                <div style="color: rgb(0, 0, 0);">Consent of Ernst &amp; Young et Autres</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.89%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);"><a href="brhc10025772_ex5-1.htm">23.2*</a></div>
              </td>
              <td style="width: 89.11%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);">Consent of Jones Day (included in Exhibit 5.1)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.89%; vertical-align: middle; background-color: rgb(204, 238, 255);">
                <div style="color: rgb(0, 0, 0);"><a href="#POWEROFATTORNEY">24.1*</a></div>
              </td>
              <td style="width: 89.11%; vertical-align: middle; background-color: rgb(204, 238, 255);">
                <div style="color: rgb(0, 0, 0);">Power of Attorney of each of the directors of the Registrant and the principal executive, financial and accounting officers of the Registrant (included on the signature page of this Form S-8).</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.89%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/1760854/000162828021006685/nanobiotix-secifrs20xf2020g.htm">99.1</a></div>
              </td>
              <td style="width: 89.11%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);">Summary of BSA Plan (incorporated herein by reference to Exhibit 4.17 to the Registrant&#8217;s Annual Report on Form 20-F/A (File No. 001-39777)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.89%; vertical-align: middle; background-color: rgb(204, 238, 255);">
                <div style="color: rgb(0, 0, 0);">
                  <div style="color: #000000;"><a href="brhc10025772_ex99-2.htm">99.2*</a></div>
                </div>
              </td>
              <td style="width: 89.11%; vertical-align: middle; background-color: rgb(204, 238, 255);">
                <div style="color: rgb(0, 0, 0);">2021 Stock Option Plan</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.89%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/1760854/000162828021006685/nanobiotix-secifrs20xf2020.htm">99.3</a></div>
              </td>
              <td style="width: 89.11%; vertical-align: middle;">
                <div style="color: rgb(0, 0, 0);">Summary of Free Share Plan (incorporated herein by reference to Exhibit 4.18 to the Registrant&#8217;s Annual Report on Form 20-F/A (File No. 001-39777)</div>
              </td>
            </tr>

        </table>
      </div>
      <div> <br>
      </div>
      <div>* Filed herewith.</div>
      <div> <br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="ze221fa05032b433f9bd621b30254da6f">

          <tr>
            <td style="width: 45pt; vertical-align: top; font-weight: bold;">ITEM 9.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">UNDERTAKINGS<a name="Prospectus_Undertakings"></a></div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div style="text-align: justify;">1.&#160;&#160; The undersigned Registrant hereby undertakes:</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">(a)&#160;&#160; To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">(i)&#160; &#160; To include any prospectus required by Section 10(a)(3) of the Securities Act;</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">(ii)&#160;&#160; To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or
        in the aggregate, represent a fundamental change in the information set forth in the Registration Statement.&#160; Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered
        would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
        changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective Registration Statement;</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">(iii)&#160;&#160; To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the
        Registration Statement;</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;"><font style="font-style: italic;">Provided, however,</font> that paragraphs (a)(i) and (a)(ii) do not apply if the information required to be included in a post-effective amendment by those
        paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement.</div>
      <div>&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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      <div style="text-align: justify; text-indent: 36pt;">(b)&#160;&#160; That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
        offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">(c)&#160; &#160; To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
      <div>&#160;</div>
      <div style="text-align: justify;">2.&#160;&#160; The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&#8217;s annual report pursuant to Section 13(a) or Section 15(d) of
        the Exchange Act (and, where applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration
        statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
      <div>&#160;</div>
      <div style="text-align: justify;">3.&#160;&#160; Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise,
        the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such
        liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
        controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
        whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</div>
      <div>&#160;</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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      </div>
      <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
        S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Paris, France on June 21, 2021.</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z958db34779b24fdeabecd258631294f6">

          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: top;">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">NANOBIOTIX S.A.</div>
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          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">&#160;</td>
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          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">By:</div>
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            <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">/s/ Laurent Levy</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Name:&#160; Laurent Levy, Ph.D.</div>
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          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Title:&#160; Chairman of the Executive Board</div>
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      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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      </div>
      <div style="text-align: center; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">We, the undersigned directors, officers and/or authorized representative in the United States of Nanobiotix S.A., hereby severally constitute and appoint Laurent Levy and Bart Van Rhijn, and each
        of them singly, our true and lawful attorneys, with full power to any of them, and to each of them singly, to sign for us and in our names in the capacities indicated below any and all pre-effective and post-effective amendments to this
        Registration Statement on Form S-8, under the Securities Act of 1933, as amended, <font style="color: rgb(0, 0, 0);">in connection with the registration under the Securities Act of 1933, as amended, of equity securities of Nanobiotix S.A., and to
          file or cause to be filed the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys, and each of them, full power and authority to do and perform
          each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as each of them might or could do in person, and hereby ratifying and confirming all that said attorneys, and each of
          them, or their substitute or substitutes, shall do or cause to be done by virtue of this Power of Attorney.</font></div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities indicated on June 21, 2021.</div>
      <div>&#160;</div>
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              <div style="color: rgb(0, 0, 0); font-weight: bold;">Signature</div>
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            <td style="width: 60%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Title</div>
            </td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">/s/ Laurent Levy</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0);">Chairman of the Executive Board</div>
            </td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Laurent Levy</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic;">(Principal Executive Officer)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">/s/ Bart Van Rhijn</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0);">Chief Financial Officer and Executive Board Member</div>
            </td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Bart Van Rhijn</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic;">(Principal Financial Officer and Principal Accounting Officer)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">/s/ Gary Phillips</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0);">Supervisory Board Chairman</div>
            </td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Gary Phillips</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
          </tr>
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            <td style="width: 34.96%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">/s/ Anne-Marie Graffin</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0);">Supervisory Board Deputy Chairman</div>
            </td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Anne-Marie Graffin</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">/s/ Alain Herrera</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0);">Supervisory Board Member</div>
            </td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Alain Herrera</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">/s/ Enno Spillner</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0);">Supervisory Board Member</div>
            </td>
          </tr>
          <tr>
            <td style="width: 34.96%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Enno Spillner</div>
            </td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 60%; vertical-align: top;">&#160;</td>
          </tr>

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      <div><br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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      <div style="text-align: center; font-weight: bold;">AUTHORIZED REPRESENTATIVE IN THE UNITED STATES</div>
      <div>&#160;</div>
      <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement on Form S-8 has been signed by the undersigned as the duly authorized representative in the
        United States of Nanobiotix S.A. in Paris, France June 21, 2021.</div>
      <div>&#160;</div>
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          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td colspan="2" style="vertical-align: top;">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">NANOBIOTIX CORPORATION</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">By:</div>
            </td>
            <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: rgb(0, 0, 0);">/s/ Bart Van Rhijn</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Name:&#160; Bart Van Rhijn</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top;">&#160;</td>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 45%; vertical-align: top;">
              <div style="color: rgb(0, 0, 0);">Title:&#160; Treasurer and Authorized Signatory</div>
            </td>
          </tr>

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      </div>
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As filed with the Securities and Exchange Commission on June 21, 20
21
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
NANOBIOTIX S.A.
(Exact name of registrant as specified in its charter)
France
Not applicable
(State or other jurisdiction of incorporation or organization)
(I.R.S. employer identification No.)
60, rue de Wattignies
75012 Paris, France
(Address of Principal Executive Offices)(Zip Code)
BSA Plan
Free Share Plan
2021 Stock Option Plan
(Full title of the plans)
Nanobiotix Corporation
Attn: Bart Van Rhijn
210 Broadway
Cambridge, Massachusetts
+1 617 712 1568
(Name and address of agent for service) (Telephone number, including area code, of agent for service)
Copies to:
Peter E. Devlin
Robert G. Marshall II
Jones Day
250 Vesey Street
New York, New York 10281
+1 212 262 3939
Renaud Bonnet
Jean-Gabriel Griboul
Jones Day
2 rue Saint-Florentin
75001 Paris, France
+33 1 56 59 39 39
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
        filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☐
Emerging growth company
☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided
                pursuant to Section 7(a)(2)(B) of the Securities Act.
☐
CALCULATION OF REGISTRATION FEE
Title of Securities
to be Registered
(1)
Amount
to be
Registered
(2) (3)
Proposed
Maximum
Offering Price
per Share
Proposed
Maximum
Aggregate
Offering Price
Amount of
Registration Fee
Ordinary shares, €0.03 nominal value per share, reserved for future issuance upon the exercise of share options (
options de souscription d'actions
or "
OSA
") issuable under the 2021 Stock Option Plan
850,000
$14.52
(4)
$12,342,000
$1,346.51
Ordinary shares, €0.03 nominal value per share, reserved for future issuance upon the exercise of share warrants (
bons de souscription d'actions
or "
BSA
") issuable under the BSA Plan
850,000
$14.52
(4)
$12,342,000
$1,346.51
Ordinary shares, €0.03 nominal value per share, reserved for future issuance upon settlement of free shares (a
ttributions gratuites d'actions
or "
AGA
") under the Free Share Plan.
850,000
$14.52
(4)
$12,342,000
$1,346.51
Aggregate Registration Fee
$4,039.53
(1)
These shares may be represented by American Depositary Shares, or ADSs, of Nanobiotix S.A. (the "
Registrant
"). Each ADS represents one ordinary share of the Registrant. The
                Registrant's ADSs issuable upon deposit of the ordinary shares registered hereby have been registered pursuant to a separate registration statement on Form F-6 (File No. 333-250880).
(2)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "
Securities Act
"), this Registration Statement shall also cover any additional ordinary shares of the
                Registrant that may become issuable under any of the plans identified on the cover of this Registration Statement by reason of any share dividend, share split, recapitalization or other similar transaction effected without receipt of
                consideration that increases the number of the Registrant's outstanding ordinary shares.
(3)
The shareholders authorization relating to the ordinary shares reserved for future issuance upon OSA, BSA and AGA grants covered by this Registration Statement further restricts the aggregate number of ordinary shares issuable to an
                aggregate of 850,000 ordinary shares.  Accordingly, notwithstanding the 2,550,000 ordinary shares registered on this Registration Statement, the aggregate amount issuable upon such future issuances cannot exceed 850,000 ordinary shares.
(4)
Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act based upon the price of $14.52 per ADS, which was the average of the high and low prices
                of the ADSs as reported on Nasdaq Global Select Market for June 18, 2021.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
The information specified in Part I of Form S-8 is omitted from this Registration Statement in accordance with the provisions of Rule 428 under the Securities Act and the introductory note to Part I of Form S-8. The
        documents containing the information specified in Part I of Form S-8 will be delivered to the participants in the plans covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
ITEM 3.
INCORPORATION OF DOCUMENTS BY REFERENCE
The following documents filed by Nanobiotix S.A. (the "
Registrant
") with the U.S. Securities and Exchange Commission (the "
Commission
") are incorporated by reference into this Registration Statement:
(a)
the Registrant's Annual Report on Form 20-F/A (File No. 001-39777) for the year ended
December 31, 2020
, filed with the Commission pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended (the "
Exchange Act
") on April 8, 2021, which contains audited financial statements for the Registrant's latest fiscal year for which such statements have been filed;
(b)
The Registrant's Reports on Form 6-K (File No. 001-39777) furnished to the Commission on
April 14, 2021
(including Exhibit 99.1),
April 28,
          2021
(including Exhibit 99.1),
April 29, 2021
(including Exhibit 99.1),
May 11, 2021
(including Exhibit 99.1),
May
          19, 2021
(including Exhibit 99.1),
May 21, 2021
(including Exhibit 99.1),
May 25, 2021
(including Exhibit 99.1),
June
          1, 2021
(including Exhibit 99.1), and
June 4, 2021
(including Exhibit 99.1), and all other reports on Form 6-K that are furnished to the
        Commission and that are identified in such form as being incorporated by reference, since the end of the fiscal year covered by the Registrant's annual report on Form 20-F/A referred to in (a) above; and
(e)
the descriptions of the Registrant's American Depositary Shares and Ordinary Shares contained in the Registrant's Registration Statement on Form 8-A
        filed with the Commission on
December 8, 2020
(File No. 001-39777) under the Securities Exchange Act of 1934, as amended (the "
Exchange Act
"), including any amendment or report filed for the purpose of updating such description.
All other reports and documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration Statement and
        prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered hereby have been sold or which deregisters all such securities then remaining unsold, shall be deemed to be incorporated by
        reference herein and to be a part of this Registration Statement from the date of filing of such reports and documents. Any statement contained in this Registration Statement, in an amendment hereto or in a document incorporated or deemed to be
        incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed amendment to this Registration Statement or in
        any document that also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this
        Registration Statement.
Information subsequently furnished on Form 6-K shall not be deemed incorporated herein by reference unless such Form 6-K expressly provides to the contrary.
ITEM 4.
DESCRIPTION OF SECURITIES
Not applicable.
ITEM 5.
INTERESTS OF NAMED EXPERTS AND COUNSEL
Not applicable.
ITEM 6.
INDEMNIFICATION OF DIRECTORS AND OFFICERS
Under French law, provisions in the By-laws that limit the liability of directors and officers are ineffective. However, French law allows
sociétés anonymes
to contract for and maintain liability insurance against civil liabilities incurred by any of their directors and officers involved in a third-party action,
provided
that they acted in good faith and within
        their capacities as directors or officers of the company. Criminal liability cannot be indemnified under French law, whether directly by the company or through liability insurance. Such rules apply to executive and supervisory board members.
The Registrant has obtained and maintains customary liability insurance coverage for our supervisory board members and executive board members, including insurance against liability under the
        Securities Act.
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to the Registrant's directors, officers and controlling persons, the Registrant has been advised that,
        in the opinion of the Commission, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.
ITEM 7.
EXEMPTION FROM REGISTRATION CLAIMED.
Not applicable.
ITEM 8.
EXHIBITS
The following exhibits are filed herewith:
Exhibit
Number
Description
3.1
By-laws of the Registrant (English translation) (incorporated herein by reference to Exhibit 3.1 to the
Registrant's Registration Statement on Form F-1 (File No. 333-250707))
4.1
Form of Deposit Agreement by and among Nanobiotix S.A. and Citibank, N.A., as depositary, and the Holders and Beneficial Owners of American Depositary Shares issued thereunder (incorporated herein by
                    reference to Exhibit 4.1 to the
Registrant's Registration Statement on Form F-1 (File No. 333-250707))
4.2
Form of American Depositary Receipt (included in Exhibit 4.1)
5.1*
Opinion of Jones Day
23.1*
Consent of Ernst & Young et Autres
23.2*
Consent of Jones Day (included in Exhibit 5.1)
24.1*
Power of Attorney of each of the directors of the Registrant and the principal executive, financial and accounting officers of the Registrant (included on the signature page of this Form S-8).
99.1
Summary of BSA Plan (incorporated herein by reference to Exhibit 4.17 to the Registrant's Annual Report on Form 20-F/A (File No. 001-39777)
99.2*
2021 Stock Option Plan
99.3
Summary of Free Share Plan (incorporated herein by reference to Exhibit 4.18 to the Registrant's Annual Report on Form 20-F/A (File No. 001-39777)
* Filed herewith.
ITEM 9.
UNDERTAKINGS
1.   The undersigned Registrant hereby undertakes:
(a)   To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)    To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)   To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or
        in the aggregate, represent a fundamental change in the information set forth in the Registration Statement.  Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered
        would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
        changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective Registration Statement;
(iii)   To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the
        Registration Statement;
Provided, however,
that paragraphs (a)(i) and (a)(ii) do not apply if the information required to be included in a post-effective amendment by those
        paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement.
(b)   That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
        offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c)    To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
2.   The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of
        the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration
        statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
3.   Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise,
        the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such
        liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
        controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question
        whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form
        S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Paris, France on June 21, 2021.
NANOBIOTIX S.A.
By:
/s/ Laurent Levy
Name:  Laurent Levy, Ph.D.
Title:  Chairman of the Executive Board
POWER OF ATTORNEY
We, the undersigned directors, officers and/or authorized representative in the United States of Nanobiotix S.A., hereby severally constitute and appoint Laurent Levy and Bart Van Rhijn, and each
        of them singly, our true and lawful attorneys, with full power to any of them, and to each of them singly, to sign for us and in our names in the capacities indicated below any and all pre-effective and post-effective amendments to this
        Registration Statement on Form S-8, under the Securities Act of 1933, as amended,
in connection with the registration under the Securities Act of 1933, as amended, of equity securities of Nanobiotix S.A., and to
          file or cause to be filed the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys, and each of them, full power and authority to do and perform
          each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as each of them might or could do in person, and hereby ratifying and confirming all that said attorneys, and each of
          them, or their substitute or substitutes, shall do or cause to be done by virtue of this Power of Attorney.
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities indicated on June 21, 2021.
Signature
Title
/s/ Laurent Levy
Chairman of the Executive Board
Laurent Levy
(Principal Executive Officer)
/s/ Bart Van Rhijn
Chief Financial Officer and Executive Board Member
Bart Van Rhijn
(Principal Financial Officer and Principal Accounting Officer)
/s/ Gary Phillips
Supervisory Board Chairman
Gary Phillips
/s/ Anne-Marie Graffin
Supervisory Board Deputy Chairman
Anne-Marie Graffin
/s/ Alain Herrera
Supervisory Board Member
Alain Herrera
/s/ Enno Spillner
Supervisory Board Member
Enno Spillner
AUTHORIZED REPRESENTATIVE IN THE UNITED STATES
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement on Form S-8 has been signed by the undersigned as the duly authorized representative in the
        United States of Nanobiotix S.A. in Paris, France June 21, 2021.
NANOBIOTIX CORPORATION
By:
/s/ Bart Van Rhijn
Name:  Bart Van Rhijn
Title:  Treasurer and Authorized Signatory