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    <div style="text-align: center;">As filed with the Securities and Exchange Commission on June 16, 2022</div>
    <div style="text-align: right;">Registration No. 333-_____</div>
  </div>
  <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;">
  <div>
    <div style="text-align: center; font-weight: bold;"><font style="font-size: 14pt;">UNITED STATES<br>
        SECURITIES AND EXCHANGE COMMISSION</font><br>
      <font style="font-size: 12pt;">Washington, D.C.&#160; 20549</font></div>
    <div>&#160;</div>
    <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT UNDER<br>
      THE SECURITIES ACT OF 1933</div>
    <div>&#160;</div>
    <div style="text-align: center; font-size: 24pt; font-weight: bold;">Infinity Pharmaceuticals, Inc.</div>
    <div style="text-align: center;">(Exact Name of Registrant as Specified in Its Charter)</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zcd5bd4cc6827447493937f4b750c9eab">

        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">Delaware</div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">33-0655706</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center;">(State or Other Jurisdiction of Incorporation or Organization)</div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center;">(I.R.S. Employer Identification No.)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;" rowspan="1">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top; text-align: center;" rowspan="1">&#160;</td>
          <td style="width: 49%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; font-weight: bold;">1100 Massachusetts Avenue, Floor 4<br>
              Cambridge, Massachusetts</div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 49%; vertical-align: bottom; text-align: center;">
            <div style="font-weight: bold;">02138</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center;">(Address of Principal Executive Offices)</div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center;">(Zip Code)</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">Infinity Pharmaceuticals, Inc. 2019 Equity Incentive Plan, as amended</div>
    <div style="text-align: center;">(Full Title of the Plan)</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z095e5df4015e409cb3b867f60fe5ad00">

        <tr>
          <td style="width: 99.89%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Seth A. Tasker, Esq.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 99.89%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Senior Vice President, Chief Business Officer<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 99.89%; vertical-align: top;">
            <div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Infinity Pharmaceuticals, Inc.</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 99.89%; vertical-align: top;">
            <div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">1100 Massachusetts Avenue, Floor 4</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 99.89%; vertical-align: top;">
            <div>
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Cambridge, Massachusetts 02138</div>
            </div>
          </td>
        </tr>

    </table>
    <div style="text-align: center;">(Name and Address of Agent For Service)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">(617) 453-1000</div>
    <div style="text-align: center;">&#160;(Telephone Number, Including Area Code, of Agent For Service)</div>
    <div>&#160;</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><font style="font-style: italic;">With copies to</font>:</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z0e50a150d5b64ab388f14e2c0c22b8b6">

        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Cynthia T. Mazareas, Esq.</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Wilmer Cutler Pickering Hale and Dorr LLP</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">60 State Street</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Boston, MA 02109</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Telephone: (617) 526-6000</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
      filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div>&#160;</div>
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        <tr>
          <td colspan="1" style="width: 21%; vertical-align: top;">&#160;</td>
          <td nowrap="nowrap" style="width: 14%; vertical-align: top;">
            <div>Large accelerated filer<br>
            </div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top;">&#9744;</td>
          <td style="width: 60%; vertical-align: top;">
            <div style="text-align: right;">Accelerated filer<br>
            </div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top;">&#9744;</td>
        </tr>
        <tr>
          <td colspan="1" style="width: 21%; vertical-align: top;">&#160;</td>
          <td style="width: 14%; vertical-align: top;">
            <div>Non-accelerated filer</div>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top;">&#9746;</td>
          <td style="width: 60%; vertical-align: top;">
            <div style="text-align: right;">Smaller reporting company</div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top;">&#9746;</td>
        </tr>
        <tr>
          <td colspan="1" style="width: 21%; vertical-align: top;">&#160;</td>
          <td style="width: 14%; vertical-align: top;"><br>
          </td>
          <td colspan="1" style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 60%; vertical-align: top;">
            <div style="text-align: right;">Emerging growth company</div>
          </td>
          <td colspan="1" style="width: 1%; vertical-align: top;">&#160;</td>
          <td colspan="1" style="width: 2%; vertical-align: top;">&#9744;</td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. &#9744;</div>
    <div>&#160;</div>
    <div>
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
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    <div style="text-align: center; font-weight: bold;">STATEMENT OF INCORPORATION BY REFERENCE</div>
    <div>&#160;</div>
    <div>This registration statement on Form S-8 is being filed to register an additional 6,500,000 shares of Common Stock of Infinity Pharmaceuticals, Inc. (the &#8220;Registrant&#8221;) issuable under the 2019 Equity Incentive Plan, as amended (the &#8220;2019 Plan&#8221;).&#160;
      Pursuant to General Instruction E to Form S-8, except for Item 5 &#8220;Interests of Named Experts and Counsel&#8221; and Item 8 &#8220;Exhibits,&#8221; this registration statement incorporates by reference the contents of the registration statement on <a href="https://www.sec.gov/Archives/edgar/data/0001113148/000119312519173034/d575966ds8.htm">Form S-8</a>, File No. 333-232110, filed by the Registrant on June 14, 2019 relating to the 2019 Plan.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">PART II<br>
      INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z05430ece353c47248e1613e25c15c74f">

        <tr>
          <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 5.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Interests of Named Experts and Counsel.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">Wilmer Cutler Pickering Hale and Dorr LLP has opined as to the legality of the securities being offered by this registration statement.</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z46c10cab7f084e9b9b52c4c63402f082">

        <tr>
          <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 8.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Exhibits.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">The Exhibit Index immediately preceding the exhibits is incorporated herein by reference.</div>
    <div>&#160;</div>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">- 1 -</font></div>
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    </div>
    <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
      registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Cambridge, Commonwealth of Massachusetts, on this 16th day of June, 2022.</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z25c3e3cf952a485bb4492304f098dc68">

        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td colspan="2" style="vertical-align: top;">
            <div style="font-weight: bold;">INFINITY PHARMACEUTICALS, INC.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 3%; vertical-align: top;">&#160;</td>
          <td style="width: 47%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 3%; vertical-align: top;">
            <div>By:</div>
          </td>
          <td style="width: 47%; vertical-align: top;">
            <div><u>/s/ Lawrence E. Bloch, M.D., J.D.</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 3%; vertical-align: top;">&#160;</td>
          <td style="width: 47%; vertical-align: top;">
            <div>Lawrence E. Bloch, M.D., J.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 3%; vertical-align: top;">&#160;</td>
          <td style="width: 47%; vertical-align: top;">
            <div>President</div>
          </td>
        </tr>

    </table>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;"><a name="POWEROFATTORNEYANDSIGNATU"><!--Anchor--></a>POWER OF ATTORNEY AND SIGNATURES</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">We, the undersigned officers and directors of Infinity Pharmaceuticals, Inc., hereby severally constitute and appoint Adelene Q. Perkins, Lawrence E. Bloch, M.D., J.D., and Seth A. Tasker, and each of them singly, our
      true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the registration statement on Form S-8 filed herewith and any and all subsequent amendments to said
      registration statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Infinity Pharmaceuticals, Inc. to comply with the provisions of the Securities Act of 1933, as amended,
      and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and all amendments thereto.</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zdb5a723f2ea14c8a92fefa8912fd879c">

        <tr>
          <td nowrap="nowrap" style="vertical-align: bottom;">
            <div style="text-align: center;">Signature</div>
          </td>
          <td nowrap="nowrap" style="vertical-align: bottom;"><br>
          </td>
          <td style="width: 46%; vertical-align: bottom;">
            <div style="text-align: center;">Title</div>
          </td>
          <td style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: center;">Date</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: middle;">&#160;</td>
          <td style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div>/s/ Adelene Q. Perkins</div>
            </div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 46%; vertical-align: top;">
            <div>Chief Executive Officer and Chair of the Board of Directors (Principal Executive Officer)</div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 10%; vertical-align: top;">
            <div>June 16, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top;">
            <div>Adelene Q. Perkins</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: middle;">&#160;</td>
          <td style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div>/s/ Lawrence E. Bloch, M.D., J.D.</div>
            </div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 46%; vertical-align: top;">
            <div>President (Principal Financial Officer and Principal Accounting Officer)</div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 10%; vertical-align: top;">
            <div>June 16, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top;">
            <div>Lawrence E. Bloch, M.D., J.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: middle;">&#160;</td>
          <td style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div>/s/ Samuel Agresta, M.D.</div>
            </div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 46%; vertical-align: top;">
            <div>Director</div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 10%; vertical-align: top;">
            <div>June 16, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top;">
            <div>Samuel Agresta, M.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: middle;">&#160;</td>
          <td style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div>/s/ David Beier, J.D.</div>
            </div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 46%; vertical-align: top;">
            <div>Director</div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 10%; vertical-align: top;">
            <div>June 16, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top;">
            <div>David Beier, J.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: middle;">&#160;</td>
          <td style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div>/s/ Anthony B. Evnin, Ph.D.</div>
            </div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 46%; vertical-align: top;">
            <div>Director</div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 10%; vertical-align: top;">
            <div>June 16, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top;">
            <div>Anthony B. Evnin, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: middle;">&#160;</td>
          <td style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/&#160;Richard Gaynor,&#160;M.D. </div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 46%; vertical-align: top;">
            <div>Director</div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 10%; vertical-align: top;">
            <div>June 16, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top;">
            <div>Richard Gaynor,&#160;M.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: middle;"><br>
          </td>
          <td style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div>/s/&#160;Sujay R. Kango</div>
            </div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 46%; vertical-align: top;">
            <div>Director</div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 10%; vertical-align: top;">
            <div>June 16, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top;">
            <div>Sujay R. Kango</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: middle;"><br>
          </td>
          <td style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td colspan="2" style="vertical-align: middle;">&#160;</td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div>/s/&#160;Brian Schwartz, M.D.</div>
            </div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 46%; vertical-align: top;">
            <div>Director<br>
            </div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: top;"><br>
          </td>
          <td rowspan="2" style="width: 10%; vertical-align: top;">
            <div>June 16, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top;">
            <div>Brian Schwartz, M.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top;"><br>
          </td>
          <td style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td colspan="2" style="vertical-align: bottom;">
            <div>&#160;&#160;</div>
          </td>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div>/s/&#160;Norman C. Selby</div>
            </div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 46%; vertical-align: top;">
            <div>Director</div>
          </td>
          <td rowspan="2" style="width: 6%; vertical-align: bottom;"><br>
          </td>
          <td rowspan="2" style="width: 10%; vertical-align: top;">
            <div>June 16, 2022</div>
          </td>
        </tr>
        <tr>
          <td style="width: 32%; vertical-align: top;">
            <div>Norman C. Selby</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">- 2 -</font></div>
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; font-weight: bold;">INDEX TO EXHIBITS</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z512fca0be84142afb54fb1e6665c462a">

        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div>
              <div>Number</div>
            </div>
          </td>
          <td nowrap="nowrap" colspan="1" style="width: 6%; vertical-align: bottom; text-align: center; padding-bottom: 2px;"><br>
          </td>
          <td nowrap="nowrap" style="width: 88%; vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>
              <div>Description</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td colspan="1" style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td style="width: 88%; vertical-align: middle;"><br>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1113148/000111314820000028/restatedcertificateofi.htm">4.1</a></div>
          </td>
          <td nowrap="nowrap" colspan="1" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);"><br>
          </td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1113148/000111314820000028/restatedcertificateofi.htm">Restated Certificate of Incorporation of the Registrant, as amended (previously filed as Exhibit 3.1 to the Registrant&#8217;s Quarterly
                Report on&#160;Form 10-Q&#160;for the quarter ended July&#160;30, 2020 (File No.&#160;000-31141) and incorporated herein by reference).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td colspan="1" style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td style="width: 88%; vertical-align: middle;"><br>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1113148/000119312509056675/dex31.htm">4.2</a></div>
          </td>
          <td nowrap="nowrap" colspan="1" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);"><br>
          </td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1113148/000119312509056675/dex31.htm">Amended and Restated Bylaws of the Registrant (previously filed as Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on March&#160;17, 2009
                (File No.&#160;000-31141) and incorporated herein by reference).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td colspan="1" style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td style="width: 88%; vertical-align: middle;"><br>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10038757_ex5-1.htm">5.1</a></div>
          </td>
          <td nowrap="nowrap" colspan="1" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);"><br>
          </td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10038757_ex5-1.htm">Opinion of Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Registrant. Filed
                herewith.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td colspan="1" style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td style="width: 88%; vertical-align: middle;"><br>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10038757_ex5-1.htm">23.1</a></div>
          </td>
          <td nowrap="nowrap" colspan="1" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);"><br>
          </td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10038757_ex5-1.htm">Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.1). Filed
                Herewith.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td colspan="1" style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td style="width: 88%; vertical-align: middle;"><br>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10038757_ex23-2.htm">23.2</a></div>
          </td>
          <td nowrap="nowrap" colspan="1" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);"><br>
          </td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="brhc10038757_ex23-2.htm">Consent of Ernst&#160;&amp; Young LLP, independent registered public accounting firm to the
                Registrant. Filed Herewith.</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td colspan="1" style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td style="width: 88%; vertical-align: middle;"><br>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="#POWEROFATTORNEYANDSIGNATU">24</a></div>
          </td>
          <td nowrap="nowrap" colspan="1" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);"><br>
          </td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="#POWEROFATTORNEYANDSIGNATU">Power of attorney (included on the signature pages of this registration statement).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: middle;">&#160;</td>
          <td colspan="1" style="width: 6%; vertical-align: middle;"><br>
          </td>
          <td style="width: 88%; vertical-align: middle;"><br>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10038757_ex99-1.htm">99.1</a></div>
          </td>
          <td nowrap="nowrap" colspan="1" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);"><br>
          </td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10038757_ex99-1.htm">2019 Equity Incentive Plan, as amended. Filed herewith.</a></div>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top;">&#160;</td>
          <td nowrap="nowrap" colspan="1" style="width: 6%; vertical-align: top;"><br>
          </td>
          <td style="width: 88%; vertical-align: top;"><br>
          </td>
        </tr>
        <tr>
          <td nowrap="nowrap" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10038757_ex107.htm">107</a></div>
          </td>
          <td nowrap="nowrap" colspan="1" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);"><br>
          </td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="brhc10038757_ex107.htm">Filing Fee Table</a></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <br>
    <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">- 3 -</font></div>
    <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
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[{"type": "S-8", "sequence": "1", "filename": "brhc10038757_s8.htm", "description": "S-8", "secsgml_size_bytes": 37688}]
{"company-data": {"conformed-name": "INFINITY PHARMACEUTICALS, INC.", "cik": "0001113148", "assigned-sic": "2834", "irs-number": "330655706", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-265654", "film-number": "221020787"}, "business-address": {"street1": "1100 MASSACHUSETTS AVENUE", "street2": "FLOOR 4", "city": "CAMBRIDGE", "state": "MA", "zip": "02138", "phone": "6174531000"}, "mail-address": {"street1": "1100 MASSACHUSETTS AVENUE", "street2": "FLOOR 4", "city": "CAMBRIDGE", "state": "MA", "zip": "02138"}, "former-company": [{"former-conformed-name": "INFINITY PHARMACEUTICALS, INC./NEW/", "date-changed": "20060913"}, {"former-conformed-name": "DISCOVERY PARTNERS INTERNATIONAL INC", "date-changed": "20000428"}]}
As filed with the Securities and Exchange Commission on June 16, 2022
Registration No. 333-_____
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
FORM S-8
REGISTRATION STATEMENT UNDER
THE SECURITIES ACT OF 1933
Infinity Pharmaceuticals, Inc.
(Exact Name of Registrant as Specified in Its Charter)
Delaware
33-0655706
(State or Other Jurisdiction of Incorporation or Organization)
(I.R.S. Employer Identification No.)
1100 Massachusetts Avenue, Floor 4
Cambridge, Massachusetts
02138
(Address of Principal Executive Offices)
(Zip Code)
Infinity Pharmaceuticals, Inc. 2019 Equity Incentive Plan, as amended
(Full Title of the Plan)
Seth A. Tasker, Esq.
Senior Vice President, Chief Business Officer
1
Infinity Pharmaceuticals, Inc.
1100 Massachusetts Avenue, Floor 4
Cambridge, Massachusetts 02138
(Name and Address of Agent For Service)
(617) 453-1000
(Telephone Number, Including Area Code, of Agent For Service)
With copies to
:
Cynthia T. Mazareas, Esq.
Wilmer Cutler Pickering Hale and Dorr LLP
60 State Street
Boston, MA 02109
Telephone: (617) 526-6000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated
      filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act. ☐
STATEMENT OF INCORPORATION BY REFERENCE
This registration statement on Form S-8 is being filed to register an additional 6,500,000 shares of Common Stock of Infinity Pharmaceuticals, Inc. (the "Registrant") issuable under the 2019 Equity Incentive Plan, as amended (the "2019 Plan"). 
      Pursuant to General Instruction E to Form S-8, except for Item 5 "Interests of Named Experts and Counsel" and Item 8 "Exhibits," this registration statement incorporates by reference the contents of the registration statement on
Form S-8
, File No. 333-232110, filed by the Registrant on June 14, 2019 relating to the 2019 Plan.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 5.
Interests of Named Experts and Counsel.
Wilmer Cutler Pickering Hale and Dorr LLP has opined as to the legality of the securities being offered by this registration statement.
Item 8.
Exhibits.
The Exhibit Index immediately preceding the exhibits is incorporated herein by reference.
- 1 -
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
      registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Cambridge, Commonwealth of Massachusetts, on this 16th day of June, 2022.
INFINITY PHARMACEUTICALS, INC.
By:
/s/ Lawrence E. Bloch, M.D., J.D.
Lawrence E. Bloch, M.D., J.D.
President
POWER OF ATTORNEY AND SIGNATURES
We, the undersigned officers and directors of Infinity Pharmaceuticals, Inc., hereby severally constitute and appoint Adelene Q. Perkins, Lawrence E. Bloch, M.D., J.D., and Seth A. Tasker, and each of them singly, our
      true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the registration statement on Form S-8 filed herewith and any and all subsequent amendments to said
      registration statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Infinity Pharmaceuticals, Inc. to comply with the provisions of the Securities Act of 1933, as amended,
      and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and all amendments thereto.
Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Adelene Q. Perkins
Chief Executive Officer and Chair of the Board of Directors (Principal Executive Officer)
June 16, 2022
Adelene Q. Perkins
/s/ Lawrence E. Bloch, M.D., J.D.
President (Principal Financial Officer and Principal Accounting Officer)
June 16, 2022
Lawrence E. Bloch, M.D., J.D.
/s/ Samuel Agresta, M.D.
Director
June 16, 2022
Samuel Agresta, M.D.
/s/ David Beier, J.D.
Director
June 16, 2022
David Beier, J.D.
/s/ Anthony B. Evnin, Ph.D.
Director
June 16, 2022
Anthony B. Evnin, Ph.D.
/s/ Richard Gaynor, M.D.
Director
June 16, 2022
Richard Gaynor, M.D.
/s/ Sujay R. Kango
Director
June 16, 2022
Sujay R. Kango
/s/ Brian Schwartz, M.D.
Director
June 16, 2022
Brian Schwartz, M.D.
/s/ Norman C. Selby
Director
June 16, 2022
Norman C. Selby
- 2 -
INDEX TO EXHIBITS
Number
Description
4.1
Restated Certificate of Incorporation of the Registrant, as amended (previously filed as Exhibit 3.1 to the Registrant's Quarterly
                Report on Form 10-Q for the quarter ended July 30, 2020 (File No. 000-31141) and incorporated herein by reference).
4.2
Amended and Restated Bylaws of the Registrant (previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on March 17, 2009
                (File No. 000-31141) and incorporated herein by reference).
5.1
Opinion of Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Registrant. Filed
                herewith.
23.1
Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.1). Filed
                Herewith.
23.2
Consent of Ernst & Young LLP, independent registered public accounting firm to the
                Registrant. Filed Herewith.
24
Power of attorney (included on the signature pages of this registration statement).
99.1
2019 Equity Incentive Plan, as amended. Filed herewith.
107
Filing Fee Table
- 3 -