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      <div style="text-align: center; color: #000000; font-weight: bold;">As filed with the Securities and Exchange Commission on March 23, 2023</div>
      <div style="text-align: right; color: #000000; font-weight: bold;">Registration No. 333-</div>
      <div>
        <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div>&#160;</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold; font-size: 18pt;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">Under</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-style: italic; font-weight: bold;">The Securities Act of 1933</div>
      <div>&#160;</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;">AVROBIO, INC.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="z810df549c507468eb76045314888eadd" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Delaware</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">81-0710585</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or other jurisdiction of incorporation or organization)</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer Identification Number)</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="z12ae7ac7d9c547fa92f50d4b1b2f0c28" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">100 Technology Square</div>
              <div style="text-align: center; color: #000000; font-weight: bold;">Sixth Floor</div>
              <div style="text-align: center; color: #000000; font-weight: bold;">Cambridge, Massachusetts</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: bottom;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">02139</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Address of Principal Executive Offices)</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Zip Code)</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">2018 Employee Stock Purchase Plan</div>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Full title of the plan)</div>
      <div>&#160;</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Geoff MacKay</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">President and Chief Executive Officer</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">100 Technology Square</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Sixth Floor</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Cambridge, MA 02139</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Name and address of agent for service)</div>
      <div>&#160;</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(617) 914-8420</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(Telephone number, including area code, of agent for service)</div>
      <div>&#160;</div>
      <div style="text-align: center; color: #000000; font-style: italic; font-weight: bold;">Copies to:</div>
      <div>&#160;</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Mitchell Bloom, Esq.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">James Xu, Esq.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Goodwin Procter LLP</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">100 Northern Avenue</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Boston, Massachusetts 02210</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(617) 570-1000</div>
      <div>&#160;</div>
      <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of <font style="color: rgb(0, 0, 0);">&#8220;</font>large



        accelerated filer,<font style="color: rgb(0, 0, 0);">&#8221;</font>&#160;<font style="color: rgb(0, 0, 0);">&#8220;</font>accelerated filer,<font style="color: rgb(0, 0, 0);">&#8221;</font>&#160;<font style="color: rgb(0, 0, 0);">&#8220;</font>smaller reporting company,<font style="color: rgb(0, 0, 0);">&#8221;</font> and <font style="color: rgb(0, 0, 0);">&#8220;</font>emerging growth company<font style="color: rgb(0, 0, 0);">&#8221;</font> in Rule 12b-2 of the Exchange Act.</div>
      <div> <br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" align="center" id="zc456a17ff93b481c915fd9460a5cd241" style="border-collapse: collapse; width: 60%; color: #000000; font-family: 'Times New Roman'; font-size: 10pt; text-align: left;">

          <tr>
            <td style="width: 20%; vertical-align: bottom;">
              <div>Large accelerated filer</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 5%; vertical-align: bottom;">&#9744;</td>
            <td style="width: 5%; vertical-align: bottom;">&#160;</td>
            <td style="width: 21%; vertical-align: bottom;">
              <div>Accelerated filer</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 5%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9744;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: middle;">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: bottom;">
              <div>Non-accelerated filer</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 5%; vertical-align: bottom;">&#9746;</td>
            <td style="width: 5%; vertical-align: bottom;">&#160;</td>
            <td style="width: 21%; vertical-align: bottom;">
              <div>Smaller reporting company</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 5%; vertical-align: bottom;">
              <div style="color: rgb(0, 0, 0);">&#9746;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: middle;">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: bottom;">&#160;</td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 5%; vertical-align: bottom;">&#160;</td>
            <td style="width: 5%; vertical-align: bottom;">&#160;</td>
            <td style="width: 21%; vertical-align: bottom;">
              <div style="text-indent: -10pt; margin-left: 10pt;">Emerging growth company</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 5%; vertical-align: bottom;">
              <div style="text-indent: -10pt; margin-left: 10pt; color: rgb(0, 0, 0);">&#9746;</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
        Securities Act. &#9744;</div>
      <div><font style="color: rgb(0, 0, 0);"> <br>
        </font></div>
      <div>
        <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><font style="color: rgb(0, 0, 0);"> </font></div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">EXPLANATORY NOTE</div>
      <div><br>
      </div>
      <div>This Registration Statement on Form S-8 is being filed for the purpose of registering additional shares of common stock under the registrant&#8217;s 2018 Employee Stock Purchase Plan (the &#8220;ESPP&#8221;).</div>
      <div>
        <div><br>
        </div>
        <div style="color: #000000;">The number of shares of common stock reserved and available for issuance under the ESPP is subject to an automatic annual increase on each January 1, by an amount equal to the lesser of (i) 1.0% of the number of shares
          of common stock issued and outstanding on the immediately preceding December 31, (ii) 1,115,700 shares or (iii) such amount as determined by the Administrator (as defined in the ESPP), currently the Compensation Committee of the registrant&#8217;s
          Board of Directors. Accordingly, on January 1, 2023, the number of shares of common stock reserved and available for issuance under the ESPP increased by 439,161 shares.</div>
        <div>&#160;</div>
        <div><font style="color: #000000;">The additional shares described above are of the same class as other securities relating to the ESPP for which the registrant&#8217;s registration statements filed on Form S-8 (Registration No. 333-225788) on June 21,
            2018, on Form S-8 (Registration No. 333-230494) on March 25, 2019, on Form S-8 </font>(Registration No. 333-237203) <font style="color: rgb(0, 0, 0);">on March 16, 2020,&#160; on Form S-8 (Registration No. </font>333-254466) on March 18, 2021 and
          on Form S-8 (Registration No. 333-263655) on March 17, 2022<font style="color: rgb(0, 0, 0);"> are effective. The information contained in the registrant&#8217;s registration statement on Form S-8 (Registration No. 333-225788) is hereby incorporated by
            reference pursuant to General Instruction E.</font></div>
      </div>
      <div><br>
      </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Part II</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
      <div>&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z51700ac0ac4146488ba77584b6245b27" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 8.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibits.</div>
            </td>
          </tr>

      </table>
      <div>&#160;</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">EXHIBIT INDEX</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"> <br>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="zc789b99721a448dca9c627f248c713e4" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

          <tr>
            <td style="width: 5%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Exhibit</div>
              <div style="text-align: center; font-weight: bold;">No.</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 93%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-weight: bold;">Description</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: middle;">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>
                <div style="color: #0563C1; font-size: 12pt;"><a style="font-size: 10pt;" href="https://www.sec.gov/Archives/edgar/data/1681087/000119312518202460/d153924dex31.htm">4.1</a></div>
              </div>
            </td>
            <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 93%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>Fourth Amended and Restated Certificate of Incorporation of the Registrant (filed as Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed on June 25, 2018 (File No. 001-38537) and incorporated herein by reference)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: middle;">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>
                <div style="color: #0563C1; font-size: 12pt;"><a style="font-size: 10pt;" href="https://www.sec.gov/Archives/edgar/data/1681087/000156459020051456/avro-ex32_90.htm">4.2</a></div>
              </div>
            </td>
            <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 93%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>Certificate of Change of Registered Agent and/or Registered Office of the Registrant (filed as Exhibit 3.2 to the Registrant&#8217;s Quarterly Report on Form 10-Q filed on November 5, 2020 (File No. 001-38537) and incorporated herein by
                reference)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top;" rowspan="1">&#160;</td>
            <td style="width: 2%; vertical-align: bottom;" rowspan="1">&#160;</td>
            <td style="width: 93%; vertical-align: top;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>
                <div style="color: #0563C1; font-size: 12pt;"><a style="font-size: 10pt;" href="https://www.sec.gov/Archives/edgar/data/1681087/000119312518202460/d153924dex32.htm">4.3</a></div>
              </div>
            </td>
            <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 93%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>Amended and Restated By-laws (filed as Exhibit 3.2 to the Registrant&#8217;s Current Report on Form 8-K filed on June 25, 2018 (File No. 001-38537) and incorporated herein by reference)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: middle;">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>
                <div style="color: #0563C1; font-size: 12pt;"><a style="font-size: 10pt;" href="https://www.sec.gov/Archives/edgar/data/1681087/000119312518175024/d562006dex42.htm">4.4</a></div>
              </div>
            </td>
            <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 93%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>Second Amended and Restated Investors&#8217; Rights Agreement among the Registrant and certain of its stockholders, dated January 9, 2018 (filed as Exhibit 4.2 to the Registrant&#8217;s Registration Statement on Form S-1 filed on May 25, 2018 (File
                No.&#160; 333-225213) and incorporated herein by reference)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: middle;">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div><a href="brhc10050092_ex5-1.htm">5.1*</a></div>
            </td>
            <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 93%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>Opinion of Goodwin Procter LLP</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: middle;">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div><a href="brhc10050092_ex23-1.htm">23.1*</a></div>
            </td>
            <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 93%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>Consent of Ernst &amp; Young LLP, Independent Registered Public Accounting Firm</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: middle;">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div><a href="brhc10050092_ex5-1.htm">23.2*</a></div>
            </td>
            <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 93%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>Consent of Goodwin Procter LLP (included in Exhibit 5.1)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: middle;">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div><a href="#POWEROFATTORNEYANDSIGNATU">24.1*</a></div>
            </td>
            <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 93%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>Power of Attorney (included on signature page)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 93%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>
                <div style="color: #0563C1; font-size: 12pt;"><a style="font-size: 10pt;" href="https://www.sec.gov/Archives/edgar/data/1681087/000119312518188630/d562006dex1014.htm">99.1</a></div>
              </div>
            </td>
            <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 93%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>2018 Employee Stock Purchase Plan (Incorporated by reference to Exhibit 10.14 to the registrant&#8217;s Registration Statement on Form S-1, as amended (File No. 333-225213))</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top;">&#160;</td>
            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 93%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div><a href="brhc10050092_ex107.htm">107*</a></div>
            </td>
            <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td style="width: 93%; vertical-align: top; background-color: rgb(204, 238, 255);">
              <div>Filing Fee Table</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="margin-left: 3pt;">*&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Filed herewith.</div>
      <div> <br>
      </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURES</div>
      <div>&#160;</div>
      <div>Pursuant to the requirements of the Securities Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on
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            <td style="width: 1%; vertical-align: bottom;" rowspan="2">&#160;</td>
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            <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
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            <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
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            <td style="width: 37.35%; vertical-align: top;">&#160;</td>
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{"company-data": {"conformed-name": "AVROBIO, Inc.", "cik": "0001681087", "assigned-sic": "2836", "irs-number": "810710585", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-270799", "film-number": "23756930"}, "business-address": {"street1": "100 TECHNOLOGY SQUARE", "street2": "6TH FLOOR", "city": "CAMBRIDGE", "state": "MA", "zip": "02139", "phone": "617.914.8420"}, "mail-address": {"street1": "100 TECHNOLOGY SQUARE", "street2": "6TH FLOOR", "city": "CAMBRIDGE", "state": "MA", "zip": "02139"}, "former-company": {"former-conformed-name": "AvroBio, Inc.", "date-changed": "20160729"}}
As filed with the Securities and Exchange Commission on March 23, 2023
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
Under
The Securities Act of 1933
AVROBIO, INC.
(Exact name of registrant as specified in its charter)
Delaware
81-0710585
(State or other jurisdiction of incorporation or organization)
(I.R.S. Employer Identification Number)
100 Technology Square
Sixth Floor
Cambridge, Massachusetts
02139
(Address of Principal Executive Offices)
(Zip Code)
2018 Employee Stock Purchase Plan
(Full title of the plan)
Geoff MacKay
President and Chief Executive Officer
100 Technology Square
Sixth Floor
Cambridge, MA 02139
(Name and address of agent for service)
(617) 914-8420
(Telephone number, including area code, of agent for service)
Copies to:
Mitchell Bloom, Esq.
James Xu, Esq.
Goodwin Procter LLP
100 Northern Avenue
Boston, Massachusetts 02210
(617) 570-1000
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of
"
large

        accelerated filer,
"
"
accelerated filer,
"
"
smaller reporting company,
"
and
"
emerging growth company
"
in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer
☒
Smaller reporting company
☒
Emerging growth company
☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
        Securities Act. ☐
EXPLANATORY NOTE
This Registration Statement on Form S-8 is being filed for the purpose of registering additional shares of common stock under the registrant's 2018 Employee Stock Purchase Plan (the "ESPP").
The number of shares of common stock reserved and available for issuance under the ESPP is subject to an automatic annual increase on each January 1, by an amount equal to the lesser of (i) 1.0% of the number of shares
          of common stock issued and outstanding on the immediately preceding December 31, (ii) 1,115,700 shares or (iii) such amount as determined by the Administrator (as defined in the ESPP), currently the Compensation Committee of the registrant's
          Board of Directors. Accordingly, on January 1, 2023, the number of shares of common stock reserved and available for issuance under the ESPP increased by 439,161 shares.
The additional shares described above are of the same class as other securities relating to the ESPP for which the registrant's registration statements filed on Form S-8 (Registration No. 333-225788) on June 21,
            2018, on Form S-8 (Registration No. 333-230494) on March 25, 2019, on Form S-8
(Registration No. 333-237203)
on March 16, 2020,  on Form S-8 (Registration No.
333-254466) on March 18, 2021 and
          on Form S-8 (Registration No. 333-263655) on March 17, 2022
are effective. The information contained in the registrant's registration statement on Form S-8 (Registration No. 333-225788) is hereby incorporated by
            reference pursuant to General Instruction E.
Part II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 8.
Exhibits.
EXHIBIT INDEX
Exhibit
No.
Description
4.1
Fourth Amended and Restated Certificate of Incorporation of the Registrant (filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on June 25, 2018 (File No. 001-38537) and incorporated herein by reference)
4.2
Certificate of Change of Registered Agent and/or Registered Office of the Registrant (filed as Exhibit 3.2 to the Registrant's Quarterly Report on Form 10-Q filed on November 5, 2020 (File No. 001-38537) and incorporated herein by
                reference)
4.3
Amended and Restated By-laws (filed as Exhibit 3.2 to the Registrant's Current Report on Form 8-K filed on June 25, 2018 (File No. 001-38537) and incorporated herein by reference)
4.4
Second Amended and Restated Investors' Rights Agreement among the Registrant and certain of its stockholders, dated January 9, 2018 (filed as Exhibit 4.2 to the Registrant's Registration Statement on Form S-1 filed on May 25, 2018 (File
                No.  333-225213) and incorporated herein by reference)
5.1*
Opinion of Goodwin Procter LLP
23.1*
Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm
23.2*
Consent of Goodwin Procter LLP (included in Exhibit 5.1)
24.1*
Power of Attorney (included on signature page)
99.1
2018 Employee Stock Purchase Plan (Incorporated by reference to Exhibit 10.14 to the registrant's Registration Statement on Form S-1, as amended (File No. 333-225213))
107*
Filing Fee Table
*          Filed herewith.
SIGNATURES
Pursuant to the requirements of the Securities Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on
        its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on the 23
rd
day of March, 2023.
AVROBIO, INC.
By:
/s/ Geoff MacKay
Geoff MacKay
President, Chief Executive Officer and
Principal Executive Officer
POWER OF ATTORNEY AND SIGNATURES
KNOW ALL BY THESE PRESENT, that each individual whose signature appears below hereby constitutes and appoints each of Geoff MacKay and Erik Ostrowski as such person
'
s true and lawful attorney-in-fact and
        agent with full power of substitution and resubstitution, for such person in such person
'
s name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective
        amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Commission granting unto each said attorney-in-fact and agent full power and authority to
        do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that any said
        attorney-in-fact and agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.
Name
Title
Date
/s/ Geoff MacKay
Director, President, Chief Executive Officer and
Principal Executive Officer
March 23, 2023
Geoff MacKay
/s/ Erik Ostrowski
Chief Financial Officer and Principal Financial
and Accounting Officer
March 23, 2023
Erik Ostrowski
/s/ Bruce Booth
Chairman of the Board of Directors
March 23, 2023
Bruce Booth, D.Phil.
/s/ Ian T. Clark
Director
March 23, 2023
Ian T. Clark
/s/ Phillip B. Donenberg
Director
March 23, 2023
Phillip B. Donenberg
/s/ Gail M. Farfel
Director
March 23, 2023
Gail M. Farfel, Ph.D.
/s/ Annalisa Jenkins
Director
March 23, 2023
Annalisa Jenkins, M.B.B.S., F.R.C.P.
/s/ Christopher Paige
Director
March 23, 2023
Christopher Paige, Ph.D.
/s/ Philip Vickers
Director
March 23, 2023
Philip Vickers, Ph.D.