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Prepared and filed by St Ives Burrups
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    <td><div align="right"><font size="2" face="serif"><b>Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</b></font></div></td>
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<p align="center"><b><font face="serif" size="3">UNITED STATES</font><br>
  SECURITIES AND EXCHANGE COMMISSION<br>
  WASHINGTON, D.C. 20549</b></p>
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<p align="center"><b><font face="serif" size="3">FORM S-8<br>
REGISTRATION STATEMENT<br>
UNDER<br>
THE SECURITIES ACT OF 1933</font></b></p>
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<p align="center"><b><font face="serif" size="3">APPLERA CORPORATION<br>
</font></b><font face="serif" size="1">      (Exact Name of Registrant as Specified
in Its Charter)</font></p>
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    <td width="50%" align="center" valign="top"><font size="2"><b>Delaware</b></font></td>
    <td align="center"><font size="2"><b>06-1534213</b></font></td>
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    <td align="center" valign="top"><font size="1">&nbsp;(State or Other Jurisdiction
    of</font></td>
    <td align="center"><font face="serif" size="1">(I.R.S. Employer</font></td>
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    <td align="center" valign="top"><font size="1">&nbsp;</font><font face="serif" size="1">Incorporation
    or Organization)</font></td>
    <td align="center"><font face="serif" size="1">Identification Number)</font></td>
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<p align="center"><font size="2" face="serif"><b>301 MERRITT 7<br>
</b></font><font size="2" face="serif"><b>NORWALK, CONNECTICUT  06851-1070<br>
</b></font><font face="serif" size="1">(Address of Principal Executive Offices, including Zip Code)</font></p>
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<p align="center"><b><font face="serif" size="3">APPLERA CORPORATION/CELERA GENOMICS GROUP<br>
</font></b><b><font face="serif" size="3">AMENDED AND RESTATED 1999 STOCK INCENTIVE PLAN<br>
</font></b><font face="serif" size="1">(Full Title of the Plan)</font></p>
<p align="center">____________________</p>
<p align="center"><font size="2" face="serif"><b>WILLIAM B. SAWCH<br>
</b></font><font size="2" face="serif"><b>Senior Vice President and General Counsel<br>
</b></font><font size="2" face="serif"><b>APPLERA CORPORATION<br>
</b></font><font size="2" face="serif"><b>301 Merritt 7<br>
</b></font><font size="2" face="serif"><b>Norwalk, Connecticut 06851-1070<br>
</b></font><font size="2" face="serif"><b>(203) 840-2000<br>
</b></font><font face="serif" size="1">(Name, Address, and Telephone Number of Agent for Service)</font></p>
<p align="center"><font size="2" face="serif"><b>CALCULATION OF REGISTRATION FEE</b></font></p>
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<td align="left" valign="bottom"><b><font size="1" face="serif">&nbsp;&nbsp;&nbsp;Title of Each Class of Securities to be Registered</font></b></td>
<td width="11%" align="center" valign="bottom"><b><font size="1" face="serif">  Amount to be</font><font size="1"><br>
      <font face="serif"> Registered (1)(2)</font></font></b></td>
<td width="13%" align="center" valign="bottom"><b><font size="1" face="serif"> Proposed Maximum</font><font size="1"><br>
      <font face="serif">Offering Price Per </font><br>
      <font face="serif">Share (3)</font></font></b></td>
<td width="14%" align="center" valign="bottom"><b><font size="1" face="serif">Proposed Maximum</font><font size="1"><br>
      <font face="serif">Aggregate Offering</font><br>
      <font face="serif">Price (3)</font></font></b></td>
<td width="12%" align="center" valign="bottom"><b><font size="1" face="serif">Amount of </font><font size="1"><br>
      <font face="serif">Registration Fee</font></font></b></td>
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<td align="left"><font size="1" face="serif"> &nbsp;&nbsp;&nbsp;Applera Corporation &#150; Celera
    Genomics Group<br>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Common Stock, par value $.01 per share (2)</font></td>
<td align="center" valign="middle"><font size="1" face="serif">1,500,000</font></td>
<td align="center" valign="middle"><font size="1" face="serif">$12.00</font></td>
<td align="center" valign="middle"><font size="1" face="serif">$18,000,000</font></td>
<td align="center" valign="middle"><font size="1" face="serif">$2,280.60</font></td>
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1.</font></td>
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<font size="1" face="serif"> Together with an indeterminate number of additional
shares that may be issued to adjust the number of shares reserved for issuance
pursuant to the Applera Corporation/Celera Genomics Group 1999 Amended and Restated
Stock Incentive Plan as the result of any future stock split, stock dividend,
or similar adjustment to the Applera Corporation &#150; Celera Genomics Group
Common Stock (the &#147;Applera &#150; Celera
Stock&#148;).
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2.</font></td>
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<font size="1" face="serif"> This Registration Statement also includes rights
to purchase Series B Participating Junior Preferred Stock, par value $.01 per
share, of the Registrant (the &#147;Rights&#148;). Until the occurrence of certain
prescribed events, the Rights are not exercisable, are evidenced by the certificates
for Applera &#150; Celera Stock, and will be transferred along with and only
with such securities. Thereafter, separate Rights certificates will be issued
representing one Right for each share of Applera &#150; Celera Stock held, subject
to adjustment pursuant to anti-dilution provisions.
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3.</font></td>
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<font size="1" face="serif"> Pursuant to Rule 457(h)(1) and Rule 457(c), the
proposed maximum offering price per share and the registration fee are based
on the reported average of the high and low prices for the Applera &#150; Celera
Stock on the New York Stock Exchange on October 25, 2004. The maximum offering
price per share is estimated solely for purposes of calculating the registration
fee.
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<p align="left"><p align="left"><font size="2" face="serif">The contents of
      the Registration Statement on Form S-8 filed by Applera Corporation (formerly
      PE Corporation) (the &#147;Company&#148;) (File No. 333-82677) on July
      12, 1999, with the Securities and Exchange Commission pursuant to the Securities
      Act of 1933, as amended, are hereby incorporated by reference in this Registration
      Statement.</font></p>
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<p align="center"><font size="2" face="serif"><b>PART II</b></font></p>
<p align="center"><font size="2" face="serif"><b>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</b></font></p>
<p align="left"><font size="2" face="serif"><b>Item 5.  Interests of Named Experts and Counsel.</b></font></p>
<div style="text-indent: 3%">
<p align="left"><font size="2" face="serif">Legal matters in connection with the shares of Applera &#150; Celera Stock subject to issuance pursuant to the Applera Corporation/Celera Genomics Group Amended and Restated 1999 Stock Incentive Plan have been passed upon by Thomas P. Livingston, Esq., Vice President and Secretary of the Company.  Mr. Livingston owns Applera &#150; Celera Stock and options to purchase Applera &#150; Celera Stock with an aggregate value in excess of $50,000.</font></p>
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<p align="left"><font size="2" face="serif"><b>Item 8.  Exhibits.</b></font></p>
<div style="text-indent: 3%">
<p align="left"><font size="2" face="serif">The following exhibits are filed
  as part of this Registration Statement:</font></p>
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<td align="left" width="12%"><font size="2" face="serif">Exhibit 3.1</font></td>
<td align="left"><font size="2" face="serif">Restated Certificate of Incorporation of Applera Corporation (incorporated by reference to Exhibit 3(i) to the Company&#146;s Quarterly Report on Form 10-Q for the fiscal quarter ended December 31, 2000 (Commission file No. 1-4389)).</font></td>
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<td width="12%" align="left"><font size="2" face="serif">Exhibit 3.2</font></td>
<td align="left"><font size="2" face="serif">By-laws of Applera Corporation (incorporated by reference to Exhibit 3.2 to the Company&#146;s Registration Statement on Form S-4 (No. 333-67797)).</font></td>
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<td width="12%" align="left"><font size="2" face="serif">Exhibit 3.3</font></td>
<td align="left"><font size="2" face="serif">Certificate of Designations of Series A Participating Junior Preferred Stock and Series B Participating Junior Preferred Stock (incorporated by reference to Exhibit A to Exhibit 4.1 to the Company&#146;s Registration Statement on Form S-4 (No. 333-67797)).</font></td>
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<td width="12%" align="left"><font size="2" face="serif">Exhibit 4.1</font></td>
<td align="left"><font size="2" face="serif">Stockholder Protection Rights Agreement
    dated as of April 28, 1999, between the Company and BankBoston N.A. (incorporated
    by reference to Exhibit 4.1 to the Company&#146;s Registration Statement
    on Form S-4 (No. 333-67797)).</font></td>
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<td width="12%" align="left"><font size="2" face="serif">Exhibit 4.2</font></td>
<td align="left"><font size="2" face="serif">Amendment to Rights Agreement dated as of April 17, 2002, among BankBoston, N.A., EquiServe Trust Company, N.A., and the Company (incorporated by reference to Exhibit 4.2 to the Company&#146;s Annual Report on Form 10-K for the fiscal year ended June 30, 2002 (Commission file number 1-4389)).</font></td>
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<p align="center"><font face="serif" size="2">2</font></p>
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    <td width="12%" align="left"><font size="2" face="serif">Exhibit 5</font></td>
    <td align="left"><font size="2" face="serif">Opinion of Thomas P. Livingston,
        Esq. (including consent).</font></td>
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    <td align="left">&nbsp;</td>
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    <td width="12%" align="left"><font size="2" face="serif">Exhibit 10.1</font></td>
    <td align="left"><font size="2" face="serif">Applera Corporation/Celera Genomics
        Group Amended and Restated 1999 Stock Incentive Plan, effective as of
        October 21, 2004 (incorporated by reference to Annex C to Schedule
        14A, filed September 17, 2004, containing the Company&#146;s definitive
        Proxy Statement for its 2004 Annual Meeting of Stockholders (Commission
        file number 1-4389)).</font></td>
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    <td align="left">&nbsp;</td>
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    <td width="12%" align="left"><font size="2" face="serif">Exhibit 23.1</font></td>
    <td align="left"><font size="2" face="serif">Consent of PricewaterhouseCoopers
        LLP.</font></td>
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    <td align="left">&nbsp;</td>
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    <td width="12%" align="left"><font size="2" face="serif">Exhibit 23.2</font></td>
    <td align="left"><font size="2" face="serif">Consent of Thomas P. Livingston,
        Esq. (included in Exhibit 5).</font></td>
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    <td width="12%" align="left"><font size="2" face="serif">Exhibit 24</font></td>
    <td align="left"><font size="2" face="serif">Power of Attorney (contained
        on the signature pages hereof).</font></td>
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<p>&nbsp;</p>
<p align="center"><font size="2" face="Times New Roman, Times, serif">3</font></p>
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<p align="center"><font size="2" face="serif"><b>SIGNATURES</b></font></p>
<p align="left"><font size="2" face="serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant
    to the requirements of the Securities Act of 1933, the Company certifies
    that it has reasonable grounds to believe that it meets all of the requirements
    for filing on Form S-8 and has duly caused this Registration Statement to
    be signed on its behalf by the undersigned, thereunto duly authorized, in
    the City of Norwalk, State of Connecticut, on October 29, 2004.</font></p>
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    <td align="left"><font size="2" face="serif">APPLERA CORPORATION</font></td>
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    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td align="left">&nbsp;</td>
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    <td><font size="2" face="serif">By:</font></td>
    <td align="left"><u><font size="2" face="Times New Roman, Times, serif">/s/
          William B. Sawch&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></u></td>
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    <td><font size="2" face="serif">&nbsp;</font></td>
    <td align="left"><font size="2" face="serif">William B. Sawch<br>
      Senior Vice President and <br>
      General Counsel</font></td>
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<p align="center"><font size="2" face="serif"><b>POWER OF ATTORNEY</b></font></p>
<p align="left"><font size="2" face="serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We, the undersigned directors and officers of the Company, do hereby constitute and appoint Dennis L. Winger and William B. Sawch, or either of them, our true and lawful attorneys and agents, to do any and all acts and things in our name and on our behalf in our capacities as directors and officers and to execute any and all instruments for us and in our names in the capacities indicated below, which said attorneys and agents, or either of them, may deem necessary or advisable to enable said corporation to comply with the Securities Act of 1933 and any rules, regulations and requirements of the Securities and Exchange Commission, in connection with this Registration Statement, including specifically, but without
limitation, power and authority to sign for us or any of us in our names in the capacities indicated below, any and all amendments (including post-effective amendments) hereto and we do hereby ratify and confirm all that said attorneys and agents, or either of them, shall do or cause to be done by virtue hereof.</font></p>
<p align="left"><font size="2" face="serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</font></p>
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    <td><font size="2" face="serif">/s/ Tony L. White</font>
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    <td width="3%">&nbsp;</td>
    <td width="35%" rowspan="2" align="left" valign="top"><font size="2" face="serif">Chairman
        of the Board,<br>
      President and<br>
      Chief Executive Officer<br>
      (Principal Executive Officer)</font><br>
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    <td width="3%">&nbsp;</td>
    <td width="29%"><font size="2" face="serif">October 29, 2004</font></td>
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    <td valign="top"><font size="2" face="serif">Tony L. White</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
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<p align="center">&nbsp;</p>
<p align="center"><font size="2" face="Times New Roman, Times, serif">4</font></p>
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    <td>/<font size="2" face="Times New Roman, Times, serif">s</font>/ <font size="2" face="serif">Dennis
        L. Winger</font><br>
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    <td width="3%">&nbsp;</td>
    <td rowspan="2" valign="top"><font size="2" face="serif">Senior Vice President
        and<br>
      </font><font size="2" face="serif">Chief Financial Officer<br>
    </font><font size="2" face="serif">(Principal Financial Officer)</font></td>
    <td width="3%">&nbsp;</td>
    <td width="29%"><font size="2" face="serif">October 29, 2004</font></td>
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    <td><font size="2" face="serif">Dennis L. Winger</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
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    <td>/<font size="2" face="Times New Roman, Times, serif">s</font>/<font size="2" face="serif"> Ugo
        D. DeBlasi</font><br>
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    <td>&nbsp;</td>
    <td><font size="2" face="serif">Controller</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">October 29, 2004</font></td>
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    <td><font size="2" face="serif">Ugo D. DeBlasi</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">&nbsp; </font><font size="2" face="serif">(Principal
        Accounting Officer)</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
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    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
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    <td>/<font size="2" face="Times New Roman, Times, serif">s</font>/ <font size="2" face="serif">Richard
        H. Ayers</font><br>
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    <td>&nbsp;</td>
    <td><font size="2" face="serif">Director</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">October 29, 2004</font></td>
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    <td><font size="2" face="serif">Richard H. Ayers</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
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    <td>&nbsp;</td>
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    <td>/<font size="2" face="Times New Roman, Times, serif">s</font>/ <font size="2" face="serif">&nbsp;</font><font size="2" face="serif">Jean-Luc
        B&eacute;lingard</font><br>
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    <td>&nbsp;</td>
    <td><font size="2" face="serif">Director</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">October 29, 2004</font></td>
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    <td><font size="2" face="serif">Jean-Luc B&eacute;lingard</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
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    <td>&nbsp;</td>
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    <td>&nbsp;</td>
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    <td>/<font size="2" face="Times New Roman, Times, serif">s</font>/ <font size="2" face="serif">&nbsp;</font><font size="2" face="serif">Robert
        H. Hayes</font><br>
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    <td>&nbsp;</td>
    <td><font size="2" face="serif">Director</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">October 29, 2004</font></td>
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    <td><font size="2" face="serif">Robert H. Hayes</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
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    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
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    <td>/<font size="2" face="Times New Roman, Times, serif">s</font>/ <font size="2" face="serif">&nbsp;</font><font size="2" face="serif">Arnold
        J. Levine</font><br>
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    <td>&nbsp;</td>
    <td><font size="2" face="serif">Director</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">October 29, 2004</font></td>
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    <td><font size="2" face="serif">Arnold J. Levine</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
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    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
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    <td>/<font size="2" face="Times New Roman, Times, serif">s</font>/ <font size="2" face="serif">&nbsp;</font><font size="2" face="serif">William
        H. Longfield</font><br>
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    <td>&nbsp;</td>
    <td><font size="2" face="serif">Director</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">October 29, 2004</font></td>
  </tr>
  <tr>
    <td><font size="2" face="serif">&nbsp;</font><font size="2" face="serif">William
        H. Longfield</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td>/<font size="2" face="Times New Roman, Times, serif">s</font>/ <font size="2" face="serif">&nbsp;</font><font size="2" face="serif">Theodore
        E. Martin</font><br>
              <hr noshade size="1">
    </td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">Director</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">October 29, 2004</font></td>
  </tr>
  <tr>
    <td><font size="2" face="serif">Theodore E. Martin</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td>/<font size="2" face="Times New Roman, Times, serif">s</font>/ <font size="2" face="serif">&nbsp;</font><font size="2" face="serif">Carolyn
        W. Slayman</font><br>
              <hr noshade size="1">
    </td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">Director</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">October 29, 2004</font></td>
  </tr>
  <tr>
    <td align="left"><font size="2" face="serif">Carolyn W. Slayman</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td><font size="2" face="Times New Roman, Times, serif">/s/</font> <font size="2" face="serif">Orin
        R. Smith</font><br>
              <hr noshade size="1">
    </td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">Director</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">October 29, 2004</font></td>
  </tr>
  <tr>
    <td><font size="2" face="serif">Orin R. Smith</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td>/<font size="2" face="Times New Roman, Times, serif">s</font>/ <font size="2" face="serif">&nbsp;</font><font size="2" face="serif">James
        R. Tobin</font><br>
              <hr noshade size="1">
    </td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">Director</font></td>
    <td>&nbsp;</td>
    <td><font size="2" face="serif">October 29, 2004</font></td>
  </tr>
  <tr>
    <td><font size="2" face="serif">James R. Tobin</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
</table>
<p align="left">&nbsp;</p>
<p align="center"><font face="serif" size="2">5</font></p>
<hr noshade align="center" width="100%" size="2">
<div style="page-break-before:always"></div>
<page>


<p align="center"><font size="2" face="serif"><b>EXHIBIT INDEX</b></font></p>
<table width="100%" cellspacing="0" cellpadding="0" border="0">
  <tr valign="top">
    <td><font size="2" face="serif"><b><u>Exhibit No.</u></b></font></td>
    <td>&nbsp;</td>
    <td align="left"><font size="2" face="serif"><b><u>Description</u></b></font></td>
  </tr>
  <tr valign="top">
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td align="left">&nbsp;</td>
  </tr>
  <tr valign="top">
    <td width="15%"><font size="2" face="serif">Exhibit 5</font></td>
    <td width="2%"><font size="2" face="serif">&nbsp;</font></td>
    <td align="left"><font size="2" face="serif"> Opinion of Thomas P. Livingston, Esq. (including consent).</font></td>
  </tr>
  <tr valign="top">
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td align="left">&nbsp;</td>
  </tr>
  <tr valign="top">
    <td><font size="2" face="serif">Exhibit 23.1</font></td>
    <td><font size="2" face="serif">&nbsp;</font></td>
    <td align="left"><font size="2" face="serif"> Consent of PricewaterhouseCoopers LLP.</font></td>
  </tr>
  <tr valign="top">
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td align="left">&nbsp;</td>
  </tr>
  <tr valign="top">
    <td><font size="2" face="serif">Exhibit 23.2</font></td>
    <td><font size="2" face="serif">&nbsp;</font></td>
    <td align="left"><font size="2" face="serif"> Consent of Thomas P. Livingston,
        Esq. (included in Exhibit 5).</font></td>
  </tr>
  <tr valign="top">
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td align="left">&nbsp;</td>
  </tr>
  <tr valign="top">
    <td><font size="2" face="serif">Exhibit 24</font></td>
    <td><font size="2" face="serif">&nbsp;</font></td>
    <td align="left"><font size="2" face="serif"> Power of Attorney (contained
        on the signature pages hereof).</font></td>
  </tr>
</table>
<p align="left">&nbsp;</p>
<hr noshade align="center" width="100%" size="2">
</body>
</html>
[{"type": "S-8", "sequence": "1", "filename": "b401868_s8.htm", "description": "REGISTRATION STATEMENT", "secsgml_size_bytes": 27661}]
{"company-data": {"conformed-name": "APPLERA CORP", "cik": "0000077551", "assigned-sic": "3826", "irs-number": "061534213", "state-of-incorporation": "DE", "fiscal-year-end": "0630"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-120087", "film-number": "041106779"}, "business-address": {"street1": "301 MERRITT 7", "city": "NORWALK", "state": "CT", "zip": "06851", "phone": "2038402000"}, "mail-address": {"street1": "301 MERRITT 7", "city": "NORWALK", "state": "CT", "zip": "06851"}, "former-company": [{"former-conformed-name": "PE CORP", "date-changed": "19990129"}, {"former-conformed-name": "PERKIN ELMER CORP", "date-changed": "19930601"}]}
Prepared and filed by St Ives Burrups
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
APPLERA CORPORATION
(Exact Name of Registrant as Specified
in Its Charter)
Delaware
06-1534213
(State or Other Jurisdiction
    of
(I.R.S. Employer
Incorporation
    or Organization)
Identification Number)
301 MERRITT 7
NORWALK, CONNECTICUT  06851-1070
(Address of Principal Executive Offices, including Zip Code)
APPLERA CORPORATION/CELERA GENOMICS GROUP
AMENDED AND RESTATED 1999 STOCK INCENTIVE PLAN
(Full Title of the Plan)
____________________
WILLIAM B. SAWCH
Senior Vice President and General Counsel
APPLERA CORPORATION
301 Merritt 7
Norwalk, Connecticut 06851-1070
(203) 840-2000
(Name, Address, and Telephone Number of Agent for Service)
CALCULATION OF REGISTRATION FEE
Title of Each Class of Securities to be Registered
Amount to be
Registered (1)(2)
Proposed Maximum
Offering Price Per
Share (3)
Proposed Maximum
Aggregate Offering
Price (3)
Amount of
Registration Fee
Applera Corporation – Celera
    Genomics Group
Common Stock, par value $.01 per share (2)
1,500,000
$12.00
$18,000,000
$2,280.60
1.
Together with an indeterminate number of additional
shares that may be issued to adjust the number of shares reserved for issuance
pursuant to the Applera Corporation/Celera Genomics Group 1999 Amended and Restated
Stock Incentive Plan as the result of any future stock split, stock dividend,
or similar adjustment to the Applera Corporation – Celera Genomics Group
Common Stock (the "Applera – Celera
Stock").
2.
This Registration Statement also includes rights
to purchase Series B Participating Junior Preferred Stock, par value $.01 per
share, of the Registrant (the "Rights"). Until the occurrence of certain
prescribed events, the Rights are not exercisable, are evidenced by the certificates
for Applera – Celera Stock, and will be transferred along with and only
with such securities. Thereafter, separate Rights certificates will be issued
representing one Right for each share of Applera – Celera Stock held, subject
to adjustment pursuant to anti-dilution provisions.
3.
Pursuant to Rule 457(h)(1) and Rule 457(c), the
proposed maximum offering price per share and the registration fee are based
on the reported average of the high and low prices for the Applera – Celera
Stock on the New York Stock Exchange on October 25, 2004. The maximum offering
price per share is estimated solely for purposes of calculating the registration
fee.
The contents of
      the Registration Statement on Form S-8 filed by Applera Corporation (formerly
      PE Corporation) (the "Company") (File No. 333-82677) on July
      12, 1999, with the Securities and Exchange Commission pursuant to the Securities
      Act of 1933, as amended, are hereby incorporated by reference in this Registration
      Statement.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 5.  Interests of Named Experts and Counsel.
Legal matters in connection with the shares of Applera – Celera Stock subject to issuance pursuant to the Applera Corporation/Celera Genomics Group Amended and Restated 1999 Stock Incentive Plan have been passed upon by Thomas P. Livingston, Esq., Vice President and Secretary of the Company.  Mr. Livingston owns Applera – Celera Stock and options to purchase Applera – Celera Stock with an aggregate value in excess of $50,000.
Item 8.  Exhibits.
The following exhibits are filed
  as part of this Registration Statement:
Exhibit 3.1
Restated Certificate of Incorporation of Applera Corporation (incorporated by reference to Exhibit 3(i) to the Company's Quarterly Report on Form 10-Q for the fiscal quarter ended December 31, 2000 (Commission file No. 1-4389)).
Exhibit 3.2
By-laws of Applera Corporation (incorporated by reference to Exhibit 3.2 to the Company's Registration Statement on Form S-4 (No. 333-67797)).
Exhibit 3.3
Certificate of Designations of Series A Participating Junior Preferred Stock and Series B Participating Junior Preferred Stock (incorporated by reference to Exhibit A to Exhibit 4.1 to the Company's Registration Statement on Form S-4 (No. 333-67797)).
Exhibit 4.1
Stockholder Protection Rights Agreement
    dated as of April 28, 1999, between the Company and BankBoston N.A. (incorporated
    by reference to Exhibit 4.1 to the Company's Registration Statement
    on Form S-4 (No. 333-67797)).
Exhibit 4.2
Amendment to Rights Agreement dated as of April 17, 2002, among BankBoston, N.A., EquiServe Trust Company, N.A., and the Company (incorporated by reference to Exhibit 4.2 to the Company's Annual Report on Form 10-K for the fiscal year ended June 30, 2002 (Commission file number 1-4389)).
2
Exhibit 5
Opinion of Thomas P. Livingston,
        Esq. (including consent).
Exhibit 10.1
Applera Corporation/Celera Genomics
        Group Amended and Restated 1999 Stock Incentive Plan, effective as of
        October 21, 2004 (incorporated by reference to Annex C to Schedule
        14A, filed September 17, 2004, containing the Company's definitive
        Proxy Statement for its 2004 Annual Meeting of Stockholders (Commission
        file number 1-4389)).
Exhibit 23.1
Consent of PricewaterhouseCoopers
        LLP.
Exhibit 23.2
Consent of Thomas P. Livingston,
        Esq. (included in Exhibit 5).
Exhibit 24
Power of Attorney (contained
        on the signature pages hereof).
3
SIGNATURES
Pursuant
    to the requirements of the Securities Act of 1933, the Company certifies
    that it has reasonable grounds to believe that it meets all of the requirements
    for filing on Form S-8 and has duly caused this Registration Statement to
    be signed on its behalf by the undersigned, thereunto duly authorized, in
    the City of Norwalk, State of Connecticut, on October 29, 2004.
APPLERA CORPORATION
By:
/s/
          William B. Sawch
William B. Sawch
Senior Vice President and
General Counsel
POWER OF ATTORNEY
We, the undersigned directors and officers of the Company, do hereby constitute and appoint Dennis L. Winger and William B. Sawch, or either of them, our true and lawful attorneys and agents, to do any and all acts and things in our name and on our behalf in our capacities as directors and officers and to execute any and all instruments for us and in our names in the capacities indicated below, which said attorneys and agents, or either of them, may deem necessary or advisable to enable said corporation to comply with the Securities Act of 1933 and any rules, regulations and requirements of the Securities and Exchange Commission, in connection with this Registration Statement, including specifically, but without
limitation, power and authority to sign for us or any of us in our names in the capacities indicated below, any and all amendments (including post-effective amendments) hereto and we do hereby ratify and confirm all that said attorneys and agents, or either of them, shall do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
/s/ Tony L. White
Chairman
        of the Board,
President and
Chief Executive Officer
(Principal Executive Officer)
October 29, 2004
Tony L. White
4
/
s
/
Dennis
        L. Winger
Senior Vice President
        and
Chief Financial Officer
(Principal Financial Officer)
October 29, 2004
Dennis L. Winger
/
s
/
Ugo
        D. DeBlasi
Controller
October 29, 2004
Ugo D. DeBlasi
(Principal
        Accounting Officer)
/
s
/
Richard
        H. Ayers
Director
October 29, 2004
Richard H. Ayers
/
s
/
Jean-Luc
        Bélingard
Director
October 29, 2004
Jean-Luc Bélingard
/
s
/
Robert
        H. Hayes
Director
October 29, 2004
Robert H. Hayes
/
s
/
Arnold
        J. Levine
Director
October 29, 2004
Arnold J. Levine
/
s
/
William
        H. Longfield
Director
October 29, 2004
William
        H. Longfield
/
s
/
Theodore
        E. Martin
Director
October 29, 2004
Theodore E. Martin
/
s
/
Carolyn
        W. Slayman
Director
October 29, 2004
Carolyn W. Slayman
/s/
Orin
        R. Smith
Director
October 29, 2004
Orin R. Smith
/
s
/
James
        R. Tobin
Director
October 29, 2004
James R. Tobin
5
EXHIBIT INDEX
Exhibit No.
Description
Exhibit 5
Opinion of Thomas P. Livingston, Esq. (including consent).
Exhibit 23.1
Consent of PricewaterhouseCoopers LLP.
Exhibit 23.2
Consent of Thomas P. Livingston,
        Esq. (included in Exhibit 5).
Exhibit 24
Power of Attorney (contained
        on the signature pages hereof).