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<p  align="center"><font size="2" face="Times New Roman">As filed with the Securities and Exchange Commission on July 3, 2003</font></p>
<p  align=right><font size="2" face="Times New Roman">Registration No. 333-</font></p>
<p  align="center"><font size="5" face="Times New Roman"><b>SECURITIES AND EXCHANGE COMMISSION<br> </b></font><font size="3"><b>Washington, D.C. 20549</b></font></p>
<p  align="center"><font size="5" face="Times New Roman"><b>Form S-8</b></font></p>
<p  align="center"><font size="2" face="Times New Roman"><b>REGISTRATION STATEMENT<br> UNDER<br> THE SECURITIES ACT OF 1933</b></font></p>
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  <p  align="center"><font size="6" face="Times New Roman"><b>The   Immune Response Corporation</b></font></p>  </td>
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  <hr size="1" width="75%" noshade color=black>

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  <p  align="center"><font size="1" face="Times New Roman"><b>(Exact   name of registrant as specified in its charter)</b></font></p>  </td>
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  <p  align="center">&nbsp;</p> </td>
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  <td width="49%" valign="bottom">
  <p  align="center"><font size="2" face="Times New Roman"><b>Delaware</b></font></p>  </td>
  <td width="1%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="49%" valign="bottom">
  <p  align="center"><font size="2" face="Times New Roman"><b>33-0225679</b></font></p>  </td>
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  <td width="49%" valign="bottom">
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  </td>
  <td width="1%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="49%" valign="bottom">
  <hr size="1" width="50%" noshade color=black>

  </td>
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  <p  align="center"><font size="1" face="Times New Roman"><b>(State or   other jurisdiction of incorporation or organization)</b></font></p>  </td>
  <td width="1%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="49%" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>(I.R.S.   Employer Identification No.)</b></font></p>  </td>
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  <td width="49%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="1%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="49%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
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  <p  align="center"><font size="2" face="Times New Roman"><b>5931 Darwin Court</b></font></p>  </td>
  <td width="1%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="49%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
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  <td width="49%" valign="bottom">
  <p  align="center"><font size="2" face="Times New Roman"><b>Carlsbad, California</b></font></p>  </td>
  <td width="1%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="49%" valign="bottom">
  <p  align="center"><font size="2" face="Times New Roman"><b>92008</b></font></p>  </td>
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  <p  align="center">&nbsp;</p> </td>
  <td width="49%" valign="bottom">
  <hr size="1"  align="center" width="25%" noshade color=black>

  </td>
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  <td width="49%" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>(Address   of Principal Executive Offices)</b></font></p>  </td>
  <td width="1%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="49%" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>(Zip Code)</b></font></p>  </td>
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  <p  align="center">&nbsp;</p> </td>
  <td width="1%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="49%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
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  <td width="100%" colspan="3"  valign="bottom">
  <p  align="center"><font size="2" face="Times New Roman"><b>THE IMMUNE REPONSE CORPORATION<br>   INDIVIDUAL STOCK GRANTS OUTSIDE OF A PLAN</b></font></p>  </td>
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  <p  align="center"><font size="1" face="Times New Roman"><b>(Full   title of the plans)</b></font></p>  </td>
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  <td width="100%" colspan="3"  valign="bottom">
  <p  align="center">&nbsp;</p> </td>
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  <p  align="center"><font size="2" face="Times New Roman">MICHAEL&#160; L. JEUB<br>   Chief Financial Officer<br>   5931 Darwin Court<br>   Carlsbad, CA 92008<br>   (760) 431-7080</font></p>  </td>
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  <td width="100%" colspan="3"  valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>(Name, address   and telephone number,including area code, of agent for service)</b></font></p>  </td>
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<p class=MsoCaption align="center"><font size="2" face="Times New Roman"><b>CALCULATION OF REGISTRATION FEE</b></font></p>
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  <p style="margin-left:1em; text-indent:-1em"><font size="1" face="Times New Roman"><b>Title of Securities to be Registered</b></font></p>  </td>
  <td width="2%" valign="bottom">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="13%" colspan="2" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>Amount to   be<br>   Registered</b></font></p>  </td>
  <td width="2%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="13%" colspan="2" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>Proposed<br>   Maximum<br>   Offering Price per<br>   Share(1)</b></font></p>  </td>
  <td width="2%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="13%" colspan="2" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>Proposed   Maximum<br>   Aggregate Offering<br>   Price(1)</b></font></p>  </td>
  <td width="2%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="13%" colspan="2" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>Amount of<br>   Registration<br>   Fee</b></font></p>  </td>
  <td width="1%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
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  <td width="38%" valign="bottom">
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  </td>
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  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="1%" valign="bottom">
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  </td>
  <td width="12%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="2%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="1%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="12%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="2%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="1%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="12%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="2%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="1%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="12%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="1%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <p style="margin-left:1em; text-indent:-1em"><font size="2" face="Times New Roman">Common Stock, par value $0.0025 (2)</font></p>  </td>
  <td width="2%" valign="bottom">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="1%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="12%" valign="bottom">
  <p  align=right><font size="2" face="Times New Roman">86,428 shares</font></p>  </td>
  <td width="2%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="1%" valign="bottom">
  <p><font size="2" face="Times New Roman">$</font></p>  </td>
  <td width="12%" valign="bottom">
  <p  align=right><font size="2" face="Times New Roman">3.17</font></p>  </td>
  <td width="2%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="1%" valign="bottom">
  <p><font size="2" face="Times New Roman">$</font></p>  </td>
  <td width="12%" valign="bottom">
  <p  align=right><font size="2" face="Times New Roman">273,976.76</font></p>  </td>
  <td width="2%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="1%" valign="bottom">
  <p><font size="2" face="Times New Roman">$</font></p>  </td>
  <td width="12%" valign="bottom">
  <p  align=right><font size="2" face="Times New Roman">22.17</font></p>  </td>
  <td width="1%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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<p><font size="2" face="Times New Roman">&nbsp;</font></p>
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  <p><font size="2" face="Times New Roman">(1)</font></p>  </td>
  <td width="95%" valign="top">
  <p><font size="2" face="Times New Roman">Estimated solely for the purpose of calculating the   registration fee pursuant to Rule 457, based upon the average of the high and   low prices as reported on the Nasdaq Stock Market on June 30, 2003.</font></p>  </td>
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  <td width="5%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="95%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="5%" valign="top">
  <p><font size="2" face="Times New Roman">(2)</font></p>  </td>
  <td width="95%" valign="top">
  <p><font size="2" face="Times New Roman">Includes Preferred Stock Purchase Rights that will   be attached to and represented by the common stock (which Preferred Stock   Purchase Rights have no market value independent of the common stock to which   they are attached) until the occurrence of certain events.</font></p>  </td>
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  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="95%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <hr size="1"  align="Left" width="25%" noshade color=black>

  </td>
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<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The Registration Statement shall become effective upon filing in accordance with Rule 462 under the Securities Act of 1933.</font></p>

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<p><font size="2" face="Times New Roman"><u>PART I</u></font></p>
<p><font size="2" face="Times New Roman"><u>INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</u></font></p>
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  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Item 1</u>.</font></p>  </td>
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  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Plan Information.</u>*</font></p>  </td>
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  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="94%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
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  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Item 2</u>.</font></p>  </td>
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  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Registrant Information   and Employee Plan Annual Information.</u>*</font></p>  </td>
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  <td width="6%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="94%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
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  <p class=MsoFooter><font size="2" face="Times New Roman">*</font></p>  </td>
  <td width="94%" valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman">Not Applicable.</font></p>  </td>
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<p><font size="2" face="Times New Roman"><u>PART II</u></font></p>
<p><font size="2" face="Times New Roman"><u>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</u></font></p>
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  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Item 3</u>.</font></p>  </td>
  <td width="93%" valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Incorporation of   Certain Documents by Reference.</u></font></p>  </td>
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<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following documents filed by Registrant with the Securities and Exchange Commission are incorporated by reference in this registration statement:</font></p>
<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Registrant&#146;s Annual Report on Form 10-K (File No. 000-18006) for the fiscal year ended December&nbsp;31, 2002 which contains, among other things, the consolidated financial statements of Registrant and certain supplementary data for the fiscal year ended December 31, 2002. </font></p>
<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Registrant&#146;s Quarterly Report on Form 10-Q (File No. 000-18006) for the quarter ended March&nbsp;31, 2003</font></p>
<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The description of Registrant&#146;s Common Stock contained in Registrant&#146;s registration statement on Form&nbsp;8-A, filed March 30, 1990.</font></p>
<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;In addition, all documents subsequently filed by Registrant pursuant to Sections&nbsp;13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be a part hereof from the date of filing of such documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document which is also deemed to be incorporated by reference herein modifies or supersedes such statement. Any such
statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</font></p>

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  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Item 4</u>.</font></p>  </td>
  <td width="94%" valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Description of   Securities.</u></font></p>  </td>
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<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</font></p>
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  <td width="6%" valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Item 5</u>.</font></p>  </td>
  <td width="94%" valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Interests of Named   Experts and Counsel.</u></font></p>  </td>
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<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Certain legal matters with respect to the validity of securities offered hereby has been passed upon for us by Pillsbury Winthrop LLP.&#160; A partner of Pillsbury Winthrop LLP owns 1,106 shares of common stock and an option to acquire 5,000 shares of our common stock.</font></p>
<font size="2" face="Times New Roman"><br clear=all>
</font>

<p><font size="2" face="Times New Roman">&nbsp;</font></p>
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  <td width="6%" valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Item 6</u>.</font></p>  </td>
  <td width="94%" valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Indemnification of   Directors and Officers.</u></font></p>  </td>
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<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Section 145 of the Delaware General Corporation Law, the &#147;Delaware GCL&#148;, permits our board of directors to indemnify any person against expenses (including attorneys&#146; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by him in connection with any threatened, pending or completed action, suit or proceeding in which such person is made a party by reason of his being or having been a director, officer, employee or agent of ours, in terms sufficiently broad to permit such indemnification under certain circumstances for liabilities (including reimbursement for expenses incurred) arising under the Securities Act of 1933, as amended. The Delaware GCL provides that indemnification pursuant to its provisions is not exclusive of other rights of indemnification to which a person may be entitled
under any by-law, agreement, vote of stockholders or disinterested directors, or otherwise. </font></p>

<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Article VII of our Restated Certificate of Incorporation, as amended, and Article V of our Bylaws, provide for indemnification of our directors, officers, employees and other agents to the maximum extent permitted by law. In addition, we have entered into separate indemnification agreements with our directors and officers that will require us, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers to the fullest extent not prohibited by law. </font></p>
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  <td width="6%" valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Item 7</u>.</font></p>  </td>
  <td width="94%" colspan="6"  valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Exemption from   Registration Claimed.</u></font></p>  </td>
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  <td width="6%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="94%" colspan="6"  valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
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  <td width="6%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="94%" colspan="6"  valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman">Not applicable.</font></p>  </td>
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  <td width="6%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="94%" colspan="6"  valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
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  <td width="6%" valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Item 8</u>.</font></p>  </td>
  <td width="94%" colspan="6"  valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Exhibits.</u></font></p>  </td>
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  <td width="6%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="94%" colspan="6"  valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
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  <td width="6%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="94%" colspan="6"  valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman">See Index to Exhibits.</font></p>  </td>
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  <td width="6%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="94%" colspan="6"  valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
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  <td width="6%" valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Item 9</u>.</font></p>  </td>
  <td width="94%" colspan="6"  valign="top">
  <p class=MsoFooter><font size="2" face="Times New Roman"><u>Undertakings.</u></font></p>  </td>
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  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="89%" colspan="4"  valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
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  <td width="100%" colspan="7"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The   undersigned Registrant hereby undertakes:</font></p>  </td>
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  <td width="7%" colspan="2" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="7%" colspan="3"  valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="85%" colspan="2" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="92%" colspan="5"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To   file, during any period in which offers or sales are being made, a   post-effective amendment to this registration statement:</font></p>  </td>
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  <td width="12%" colspan="4"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" colspan="2" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="80%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="12%" colspan="4"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="87%" colspan="3"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To   include any prospectus required by section&nbsp;10(a)(3) of the Securities   Act of 1933;</font></p>  </td>
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  <td width="12%" colspan="4"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="87%" colspan="3"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="12%" colspan="4"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="87%" colspan="3"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To   reflect in the prospectus any facts or events arising after the effective   date of the registration statement (or the most recent post-effective   amendment thereof) which, individually or in the aggregate, represent a   fundamental change in the information set forth in the registration   statement;</font></p>  </td>
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  <td width="12%" colspan="4"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="87%" colspan="3"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="12%" colspan="4"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="87%" colspan="3"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To   include any material information with respect to the plan of distribution not   previously disclosed in the registration statement or any material change to   such information in the registration statement;</font></p>  </td>
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  <td width="12%" colspan="4"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="87%" colspan="3"  valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="92%" colspan="5"  valign="top">
  <p><font size="2" face="Times New Roman">provided, however, that paragraphs (a)(1)(i) and   (a)(1)(ii) do not apply if the registration statement is on Form&nbsp;S-3 or   Form S-8, and the information required to be included in a post-effective   amendment by those paragraphs is contained in periodic reports filed by the   Registrant pursuant to section&nbsp;13 or section&nbsp;15(d) of the   Securities Exchange Act of 1934 that are incorporated by reference in the   registration statement.</font></p>  </td>
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  <td width=43 style='border:none'></td>
  <td width=12></td>
  <td width=17></td>
  <td width=15></td>
  <td width=20></td>
  <td width=35></td>
  <td width=579></td>
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</font>

<p><font size="2" face="Times New Roman">&nbsp;</font></p>
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 <tr>
  <td width="8%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="92%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;That,   for the purpose of determining any liability under the Securities Act of   1933, each such post-effective amendment shall be deemed to be a new   registration statement relating to the securities offered therein, and the offering   of such securities at that time shall be deemed to be the initial bona fide   offering thereof.</font></p>  </td>
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  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="92%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="92%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;To   remove from registration by means of a post-effective amendment any of the   securities being registered which remain unsold at the termination of the   offering.</font></p>  </td>
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  <td width="7%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="92%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="100%" colspan="2" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The   undersigned Registrant hereby further undertakes that, for purposes of   determining any liability under the Securities Act of 1933, each filing of   the Registrant&#146;s annual report pursuant to section&nbsp;13(a) or section   15(d) of the Securities Exchange Act of 1934 that is incorporated by   reference in the registration statement shall be deemed to be a new   registration statement relating to the securities offered therein, and the   offering of such securities at that time shall be deemed to be the initial   bona fide offering thereof.</font></p>  </td>
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  <td width="100%" colspan="2" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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 <tr>
  <td width="100%" colspan="2" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insofar   as indemnification for liabilities arising under the Securities Act of 1933   may be permitted to directors, officers and controlling persons of the   Registrant pursuant to the foregoing provisions, or otherwise, the Registrant   has been advised that in the opinion of the Securities and Exchange   Commission such indemnification is against public policy as expressed in the   Securities Act of 1933 and is, therefore, unenforceable.&#160; In the event that a claim for   indemnification against such liabilities (other than the payment by the   Registrant of expenses incurred or paid by a director, officer or controlling   person of the Registrant in the successful defense of any action, suit or   proceeding) is asserted by such director, officer
or controlling person in   connection with the securities being registered, the Registrant will, unless   in the opinion of its counsel the matter has been settled by controlling   precedent, submit to a court of appropriate jurisdiction the question whether   such indemnification by it is against public policy as expressed in the   Securities Act of 1933 and will be governed by the final adjudication of such   issue.</font></p>  </td>
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<font size="2" face="Times New Roman"><br clear=all>
</font>

<p  align="center"><font size="2" face="Times New Roman"><u>SIGNATURES</u></font></p>
<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form&nbsp;S-8, and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Carlsbad, State of California, on July 1, 2003.</font></p>
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  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="44%" colspan="2" valign="bottom">
  <p class=MsoFooter><font size="2" face="Times New Roman">THE IMMUNE RESPONSE CORPORATION</font></p>  </td>
  <td width="13%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="41%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="3%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="40%" valign="bottom">
  <p  align="center">&nbsp;</p> </td>
  <td width="13%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="41%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="3%" valign="bottom">
  <p><font size="2" face="Times New Roman">By</font></p>  </td>
  <td width="40%" valign="bottom">
  <p  align="center"><font size="2" face="Times New Roman">/s/ M<small>ICHAEL</small> L. J<small>EUB</small></font></p>  </td>
  <td width="13%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="41%" valign="top">
  <p class=MsoFooter>&nbsp;</p> </td>
  <td width="3%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="40%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="13%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="41%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="3%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="40%" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>Michael&nbsp;L.   Jeub</b></font></p>  </td>
  <td width="13%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
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  <td width="41%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="3%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="40%" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>Chief   Financial Officer and Vice President of Finance</b></font></p>  </td>
  <td width="13%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
</table>

<p  align="center"><font size="2" face="Times New Roman"><u>POWER OF ATTORNEY</u></font></p>
<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Michael L. Jeub and John N. Bonfiglio, and each of them his true and lawful attorneys-in-fact and agents, each with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this registration statement, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said
attorneys-in-fact and agents, or his substitute or substitutes, may do or cause to be done by virtue hereof.</font></p>
<p><font size="2" face="Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the date indicated:</font></p>
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 <tr>
  <td width="39%" valign="bottom">
  <p style="margin-left:1em; text-indent:-1em"><font size="1" face="Times New Roman"><b>Name</b></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>Title</b></font></p>  </td>
  <td width="7%" valign="top">
  <p  align="center">&nbsp;</p> </td>
  <td width="11%" valign="bottom">
  <p  align="center"><font size="1" face="Times New Roman"><b>Date</b></font></p>  </td>
 </tr>
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  <td width="39%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
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  <td width="39%" valign="bottom">
  <p align=center><font size="2" face="Times New Roman">/s/ J<small>OHN</small> N. B<small>ONFIGLIO</small></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">Chief Executive Officer and Director</font></p>  </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">July 1, 2003</font></p>  </td>
 </tr>
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  <td width="39%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="39%" valign="bottom">
  <p align=center><font size="1" face="Times New Roman"><b>John N.   Bonfiglio</b></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
 <tr>
  <td width="39%" valign="bottom">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="39%" valign="bottom">
<p align=center><font size="2" face="Times New Roman">/s/ M<small>ICHAEL</small> L. J<small>EUB</small></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" rowspan="2"  valign="bottom">
  <p><font size="2" face="Times New Roman">Chief Financial Officer, Vice President of <br>   Finance, Secretary and Treasurer</font></p>  </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">July 1, 2003</font></p>  </td>
 </tr>
 <tr>
  <td width="39%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
 <tr>
  <td width="39%" valign="bottom">
  <p align=center><font size="1" face="Times New Roman"><b>Michael L.   Jeub</b></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
</table>

<font size="2" face="Times New Roman"></font>


<table align="center"  border="0" style="border-collapse:collapse" cellspacing="0"  cellpadding="0"  width="100%">
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  <td width="39%" valign="bottom">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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  <td width="39%" valign="bottom">
<p align=center><font size="2" face="Times New Roman">/s/ A<small>LAN</small> S. R<small>OSENTHAL</small></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">Director</font></p>  </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">July 1, 2003</font></p>  </td>
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  <td width="39%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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 <tr>
  <td width="39%" valign="bottom">
  <p align=center><font size="1" face="Times New Roman"><b>Alan S.   Rosenthal</b></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
 <tr>
  <td width="39%" valign="bottom">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
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 <tr>
  <td width="39%" valign="bottom">
<p align=center><font size="2" face="Times New Roman">/s/ J<small>ED</small> B. T<small>ROSPER</small></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">Director</font></p>  </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">July 1, 2003</font></p>  </td>
 </tr>
 <tr>
  <td width="39%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
 <tr>
  <td width="39%" valign="bottom">
  <p align=center><font size="1" face="Times New Roman"><b>Jed B.   Trosper</b></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
 <tr>
  <td width="39%" valign="bottom">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
 <tr>
  <td width="39%" valign="bottom">
<p align=center><font size="2" face="Times New Roman">/s/ D<small>ENNIS</small> J. C<small>ARLO</small></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">Director</font></p>  </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">July 1, 2003</font></p>  </td>
 </tr>
 <tr>
  <td width="39%" valign="bottom">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
 <tr>
  <td width="39%" valign="bottom">
  <p align=center><font size="1" face="Times New Roman"><b>Dennis J.   Carlo</b></font></p>  </td>
  <td width="8%" valign="top">
  <p style="margin-left:1em; text-indent:-1em">&nbsp;</p> </td>
  <td width="33%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="7%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="11%" valign="bottom">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
 </tr>
</table>

<p><font size="2" face="Times New Roman"><u>INDEX TO EXHIBITS</u></font></p>
<table align="center"  border="0" style="border-collapse:collapse" cellspacing="0"  cellpadding="0"  width="100%">
 <tr>
  <td width="10%" valign="top">
  <p><font size="1" face="Times New Roman"><b>Number</b></font></p>  </td>
  <td width="8%" valign="top">
  <p  align="center">&nbsp;</p> </td>
  <td width="81%" valign="top">
  <p  align="center"><font size="1" face="Times New Roman"><b>Exhibit</b></font></p>  </td>
 </tr>
 <tr>
  <td width="10%" valign="top">
  <hr size="1" width="100%" noshade color=black>

  </td>
  <td width="8%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="81%" valign="top">
  <hr size="1" width="100%" noshade color=black>

  </td>
 </tr>
 <tr>
  <td width="10%" valign="top">
  <p  align="center"><font size="2" face="Times New Roman">&#160; 5.1</font></p>  </td>
  <td width="8%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="81%" valign="top">
  <p><font size="2" face="Times New Roman">Opinion of Pillsbury Winthrop LLP.</font></p>  </td>
 </tr>
 <tr>
  <td width="10%" valign="top">
  <p  align="center"><font size="2" face="Times New Roman">10.1</font></p>  </td>
  <td width="8%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="81%" valign="top">
  <p><font size="2" face="Times New Roman">Consulting Agreement, by and between the Company and   Randall Letcavage and <br>   Rosemary Nguyen, effective as of May 30, 2003.</font></p>  </td>
 </tr>
 <tr>
  <td width="10%" valign="top">
  <p  align="center"><font size="2" face="Times New Roman">10.2</font></p>  </td>
  <td width="8%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="81%" valign="top">
  <p><font size="2" face="Times New Roman">Consultant Agreement, by and between the Company and   CEOcast, Inc., dated as of </font></p>  </td>
 </tr>
 <tr>
  <td width="10%" valign="top">
  <p  align="center"><font size="2" face="Times New Roman">&nbsp;</font></p>  </td>
  <td width="8%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="81%" valign="top">
  <p><font size="2" face="Times New Roman">June 4, 2003.</font></p>  </td>
 </tr>
 <tr>
  <td width="10%" valign="top">
  <p  align="center"><font size="2" face="Times New Roman">23.1</font></p>  </td>
  <td width="8%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="81%" valign="top">
  <p><font size="2" face="Times New Roman">Consent of BDO Seidman, LLP.</font></p>  </td>
 </tr>
 <tr>
  <td width="10%" valign="top">
  <p  align="center"><font size="2" face="Times New Roman">23.2</font></p>  </td>
  <td width="8%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="81%" valign="top">
  <p><font size="2" face="Times New Roman">Consent of Pillsbury Winthrop LLP (included in   Exhibit&nbsp;5.1).</font></p>  </td>
 </tr>
 <tr>
  <td width="10%" valign="top">
  <p  align="center"><font size="2" face="Times New Roman">24.1</font></p>  </td>
  <td width="8%" valign="top">
  <p><font size="2" face="Times New Roman">&nbsp;</font></p> </td>
  <td width="81%" valign="top">
  <p><font size="2" face="Times New Roman">Power of Attorney (see page 5).</font></p>  </td>
 </tr>
</table>

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[{"type": "S-8", "sequence": "1", "filename": "ti30685s-8.htm", "description": "FORM S-8", "secsgml_size_bytes": 51635}]
{"company-data": {"conformed-name": "IMMUNE RESPONSE CORP", "cik": "0000817785", "assigned-sic": "2836", "irs-number": "330255679", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-106812", "film-number": "03775493"}, "business-address": {"street1": "5935 DARWIN COURT", "city": "CARLSBAD", "state": "CA", "zip": "92008", "phone": "6194317080"}, "mail-address": {"street1": "5935 DARWIN COURT", "city": "CARLSBAD", "state": "CA", "zip": "92008"}}
As filed with the Securities and Exchange Commission on July 3, 2003
Registration No. 333-
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
The   Immune Response Corporation
(Exact   name of registrant as specified in its charter)
Delaware
33-0225679
(State or   other jurisdiction of incorporation or organization)
(I.R.S.   Employer Identification No.)
5931 Darwin Court
Carlsbad, California
92008
(Address   of Principal Executive Offices)
(Zip Code)
THE IMMUNE REPONSE CORPORATION
INDIVIDUAL STOCK GRANTS OUTSIDE OF A PLAN
(Full   title of the plans)
MICHAEL  L. JEUB
Chief Financial Officer
5931 Darwin Court
Carlsbad, CA 92008
(760) 431-7080
(Name, address   and telephone number,including area code, of agent for service)
CALCULATION OF REGISTRATION FEE
Title of Securities to be Registered
Amount to   be
Registered
Proposed
Maximum
Offering Price per
Share(1)
Proposed   Maximum
Aggregate Offering
Price(1)
Amount of
Registration
Fee
Common Stock, par value $0.0025 (2)
86,428 shares
$
3.17
$
273,976.76
$
22.17
(1)
Estimated solely for the purpose of calculating the   registration fee pursuant to Rule 457, based upon the average of the high and   low prices as reported on the Nasdaq Stock Market on June 30, 2003.
(2)
Includes Preferred Stock Purchase Rights that will   be attached to and represented by the common stock (which Preferred Stock   Purchase Rights have no market value independent of the common stock to which   they are attached) until the occurrence of certain events.
The Registration Statement shall become effective upon filing in accordance with Rule 462 under the Securities Act of 1933.
PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Item 1
.
Plan Information.
*
Item 2
.
Registrant Information   and Employee Plan Annual Information.
*
*
Not Applicable.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3
.
Incorporation of   Certain Documents by Reference.
The following documents filed by Registrant with the Securities and Exchange Commission are incorporated by reference in this registration statement:
(1)          Registrant's Annual Report on Form 10-K (File No. 000-18006) for the fiscal year ended December 31, 2002 which contains, among other things, the consolidated financial statements of Registrant and certain supplementary data for the fiscal year ended December 31, 2002.
(2)          Registrant's Quarterly Report on Form 10-Q (File No. 000-18006) for the quarter ended March 31, 2003
(3)          The description of Registrant's Common Stock contained in Registrant's registration statement on Form 8-A, filed March 30, 1990.
In addition, all documents subsequently filed by Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be a part hereof from the date of filing of such documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document which is also deemed to be incorporated by reference herein modifies or supersedes such statement. Any such
statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
Item 4
.
Description of   Securities.
Not applicable.
Item 5
.
Interests of Named   Experts and Counsel.
Certain legal matters with respect to the validity of securities offered hereby has been passed upon for us by Pillsbury Winthrop LLP.  A partner of Pillsbury Winthrop LLP owns 1,106 shares of common stock and an option to acquire 5,000 shares of our common stock.
Item 6
.
Indemnification of   Directors and Officers.
Section 145 of the Delaware General Corporation Law, the "Delaware GCL", permits our board of directors to indemnify any person against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by him in connection with any threatened, pending or completed action, suit or proceeding in which such person is made a party by reason of his being or having been a director, officer, employee or agent of ours, in terms sufficiently broad to permit such indemnification under certain circumstances for liabilities (including reimbursement for expenses incurred) arising under the Securities Act of 1933, as amended. The Delaware GCL provides that indemnification pursuant to its provisions is not exclusive of other rights of indemnification to which a person may be entitled
under any by-law, agreement, vote of stockholders or disinterested directors, or otherwise.
Article VII of our Restated Certificate of Incorporation, as amended, and Article V of our Bylaws, provide for indemnification of our directors, officers, employees and other agents to the maximum extent permitted by law. In addition, we have entered into separate indemnification agreements with our directors and officers that will require us, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers to the fullest extent not prohibited by law.
Item 7
.
Exemption from   Registration Claimed.
Not applicable.
Item 8
.
Exhibits.
See Index to Exhibits.
Item 9
.
Undertakings.
(a)          The   undersigned Registrant hereby undertakes:
(1)          To   file, during any period in which offers or sales are being made, a   post-effective amendment to this registration statement:
(i)          To   include any prospectus required by section 10(a)(3) of the Securities   Act of 1933;
(ii)         To   reflect in the prospectus any facts or events arising after the effective   date of the registration statement (or the most recent post-effective   amendment thereof) which, individually or in the aggregate, represent a   fundamental change in the information set forth in the registration   statement;
(iii)        To   include any material information with respect to the plan of distribution not   previously disclosed in the registration statement or any material change to   such information in the registration statement;
provided, however, that paragraphs (a)(1)(i) and   (a)(1)(ii) do not apply if the registration statement is on Form S-3 or   Form S-8, and the information required to be included in a post-effective   amendment by those paragraphs is contained in periodic reports filed by the   Registrant pursuant to section 13 or section 15(d) of the   Securities Exchange Act of 1934 that are incorporated by reference in the   registration statement.
(2)          That,   for the purpose of determining any liability under the Securities Act of   1933, each such post-effective amendment shall be deemed to be a new   registration statement relating to the securities offered therein, and the offering   of such securities at that time shall be deemed to be the initial bona fide   offering thereof.
(3)          To   remove from registration by means of a post-effective amendment any of the   securities being registered which remain unsold at the termination of the   offering.
(b)          The   undersigned Registrant hereby further undertakes that, for purposes of   determining any liability under the Securities Act of 1933, each filing of   the Registrant's annual report pursuant to section 13(a) or section   15(d) of the Securities Exchange Act of 1934 that is incorporated by   reference in the registration statement shall be deemed to be a new   registration statement relating to the securities offered therein, and the   offering of such securities at that time shall be deemed to be the initial   bona fide offering thereof.
(c)          Insofar   as indemnification for liabilities arising under the Securities Act of 1933   may be permitted to directors, officers and controlling persons of the   Registrant pursuant to the foregoing provisions, or otherwise, the Registrant   has been advised that in the opinion of the Securities and Exchange   Commission such indemnification is against public policy as expressed in the   Securities Act of 1933 and is, therefore, unenforceable.  In the event that a claim for   indemnification against such liabilities (other than the payment by the   Registrant of expenses incurred or paid by a director, officer or controlling   person of the Registrant in the successful defense of any action, suit or   proceeding) is asserted by such director, officer
or controlling person in   connection with the securities being registered, the Registrant will, unless   in the opinion of its counsel the matter has been settled by controlling   precedent, submit to a court of appropriate jurisdiction the question whether   such indemnification by it is against public policy as expressed in the   Securities Act of 1933 and will be governed by the final adjudication of such   issue.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8, and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Carlsbad, State of California, on July 1, 2003.
THE IMMUNE RESPONSE CORPORATION
By
/s/ M
ICHAEL
L. J
EUB
Michael L.   Jeub
Chief   Financial Officer and Vice President of Finance
POWER OF ATTORNEY
KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Michael L. Jeub and John N. Bonfiglio, and each of them his true and lawful attorneys-in-fact and agents, each with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this registration statement, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said
attorneys-in-fact and agents, or his substitute or substitutes, may do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the date indicated:
Name
Title
Date
/s/ J
OHN
N. B
ONFIGLIO
Chief Executive Officer and Director
July 1, 2003
John N.   Bonfiglio
/s/ M
ICHAEL
L. J
EUB
Chief Financial Officer, Vice President of
Finance, Secretary and Treasurer
July 1, 2003
Michael L.   Jeub
/s/ A
LAN
S. R
OSENTHAL
Director
July 1, 2003
Alan S.   Rosenthal
/s/ J
ED
B. T
ROSPER
Director
July 1, 2003
Jed B.   Trosper
/s/ D
ENNIS
J. C
ARLO
Director
July 1, 2003
Dennis J.   Carlo
INDEX TO EXHIBITS
Number
Exhibit
5.1
Opinion of Pillsbury Winthrop LLP.
10.1
Consulting Agreement, by and between the Company and   Randall Letcavage and
Rosemary Nguyen, effective as of May 30, 2003.
10.2
Consultant Agreement, by and between the Company and   CEOcast, Inc., dated as of
June 4, 2003.
23.1
Consent of BDO Seidman, LLP.
23.2
Consent of Pillsbury Winthrop LLP (included in   Exhibit 5.1).
24.1
Power of Attorney (see page 5).