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    <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">As filed with the Securities and Exchange Commission on May 24, 2021</div>
    <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">Registration No. 333-</div>
    <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">
      <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"> </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">WASHINGTON, D.C. 20549</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;"> <br>
    </div>
    <div>
      <hr style="background-color: rgb(0, 0, 0); border-width: medium; border-style: none; border-color: -moz-use-text-color; margin: 0px auto; height: 2px; width: 20%; color: rgb(0, 0, 0); text-align: center;" align="center" noshade="noshade"></div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;"> <br>
    </div>
    <div>
      <hr style="background-color: rgb(0, 0, 0); border-width: medium; border-style: none; border-color: -moz-use-text-color; margin: 0px auto; height: 2px; width: 20%; color: rgb(0, 0, 0); text-align: center;" align="center" noshade="noshade"></div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-variant: small-caps; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 24pt; font-variant: small-caps; font-weight: bold;">Nuwellis, Inc.</div>
    <div style="text-align: center; margin-left: 1.8pt; font-family: 'Times New Roman',Times,serif;">(Exact name of registrant as specified in its charter)</div>
    <div><br>
    </div>
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        <tr>
          <td style="width: 40%; vertical-align: top; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-weight: bold;">Delaware</div>
          </td>
          <td style="width: 20%; vertical-align: top; text-align: center; padding-bottom: 2px;">&#160;</td>
          <td style="width: 40%; vertical-align: top; text-align: center; padding-bottom: 2px; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-weight: bold;">68-0533453</div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: top; text-align: center;">
            <div>(State or other jurisdiction of&#160; </div>
            <div>incorporation or organization)</div>
          </td>
          <td style="width: 20%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 40%; vertical-align: top; text-align: center;">
            <div>(I.R.S. Employer Identification No.)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" id="z4bef0fa004674f23a816aa928d31102c" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 40%; vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-weight: bold;">12988 Valley View Road </div>
            <div style="font-weight: bold;">Eden Prairie, Minnesota</div>
          </td>
          <td style="width: 20%; vertical-align: bottom; text-align: center; padding-bottom: 2px;">&#160;</td>
          <td style="width: 40%; vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-weight: bold;">55344</div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: bottom; text-align: center;">
            <div>(Address of Principal Executive Offices)</div>
          </td>
          <td style="width: 20%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 40%; vertical-align: bottom; text-align: center;">
            <div>(Zip Code)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" id="z4dd2b5725ca84f5091bd7503c90d0674" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">Nuwellis, Inc. 2021 Inducement Plan</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center;">(Full title of the plan)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>
      <div style="text-align: center; font-weight: bold;">Nestor Jaramillo</div>
    </div>
    <div>
      <div style="text-align: center; font-weight: bold;">Chief Executive Officer</div>
    </div>
    <div>
      <div style="text-align: center; font-weight: bold;">Nuwellis, Inc.</div>
      <div>
        <div style="text-align: center; font-weight: bold;">12988 Valley View Road</div>
      </div>
      <div style="text-align: center; font-weight: bold;">Eden Prairie, MN 55344</div>
      <div style="text-align: center; font-weight: bold;">
        <div style="font-weight: bold;">(952) 345-4200</div>
        <div style="font-weight: bold;">
          <hr style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000;" align="center" noshade="noshade"></div>
        <div style="font-weight: normal;">
          <div>(Name, address and telephone number, including area code, of agent for service)</div>
        </div>
        <div>
          <div style="font-weight: bold;">Copy to:</div>
        </div>
        <div><br>
        </div>
        <div>
          <div style="font-weight: bold;">Phillip D. Torrence, Esq.</div>
        </div>
        <div>
          <div style="font-weight: bold;">Honigman LLP</div>
          <div style="font-weight: normal;">
            <div>650 Trade Center Way, Ste 200</div>
          </div>
          <div style="font-weight: normal;">Kalamazoo, MI 49002</div>
          <div>
            <div style="font-weight: normal;">(269) 337-7700</div>
          </div>
          <div> <br>
          </div>
        </div>
      </div>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the
      definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
    <div><br>
    </div>
    <div>
      <div style="text-align: center;">Large accelerated filer&#160; &#9744;&#160;&#160; Accelerated filer&#160; &#9744;</div>
    </div>
    <div style="text-align: center;">
      <div>Non-accelerated filer&#160; &#9746;&#160;&#160; Smaller reporting company&#160; &#9746;</div>
      <div style="margin-left: 81pt;">Emerging growth company &#9744;</div>
    </div>
    <div> </div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
      provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
    <table id="z4deb1819511946e1976511d7d24b7c0f" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; text-align: left; color: rgb(0, 0, 0); width: 100%;" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; width: 40%;">
            <div style="font-weight: bold;">Title of securities to be registered</div>
          </td>
          <td colspan="1" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; width: 1%; text-align: center;">&#160;</td>
          <td colspan="2" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; text-align: center;" nowrap="nowrap">
            <div style="font-weight: bold;">Amount to be</div>
            <div style="font-weight: bold;">Registered (1)</div>
          </td>
          <td colspan="1" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; white-space: nowrap; width: 1%; text-align: center;">&#160;</td>
          <td colspan="1" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; width: 1%; text-align: center;">&#160;</td>
          <td colspan="2" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; text-align: center;" nowrap="nowrap">
            <div style="font-weight: bold;">Proposed maximum </div>
            <div style="font-weight: bold;">offering price </div>
            <div style="font-weight: bold;">per share</div>
          </td>
          <td colspan="1" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; white-space: nowrap; width: 2%; text-align: center;">&#160;</td>
          <td colspan="1" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; width: 2%; text-align: center;">&#160;</td>
          <td colspan="2" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; text-align: center;" nowrap="nowrap">
            <div style="font-weight: bold;">Proposed maximum</div>
            <div style="font-weight: bold;"> aggregate offering </div>
            <div style="font-weight: bold;">price</div>
          </td>
          <td colspan="1" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; white-space: nowrap; width: 2%; text-align: center;">&#160;</td>
          <td colspan="1" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; width: 2%; text-align: center;">&#160;</td>
          <td colspan="2" style="border-bottom: 2px solid rgb(0, 0, 0); border-top: 4px double rgb(0, 0, 0); vertical-align: bottom; text-align: center;" nowrap="nowrap">
            <div style="font-weight: bold;">Amount of </div>
            <div style="font-weight: bold;">registration </div>
            <div style="font-weight: bold;">fee</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; white-space: nowrap; width: 1%; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); width: 40%;" valign="bottom">
            <div style="font-weight: bold;">Common Stock, par value $0.0001 per share</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" nowrap="nowrap" valign="bottom">&#160;</td>
        </tr>
        <tr>
          <td style="vertical-align: top; width: 40%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">
            <div>Nuwellis, Inc. 2021 Inducement Plan</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
            <div>250,000</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
            <div>$</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 13%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
            <div>3.59</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
            <div>(2)</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
            <div>$</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 12%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
            <div>897,500</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">
            <div>(2)</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; background-color: rgb(204, 238, 255); border-bottom: 4px double rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
            <div>$</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(204, 238, 255);" valign="bottom">
            <div>97.92</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 4px;" nowrap="nowrap" valign="bottom">&#160;</td>
        </tr>
        <tr>
          <td style="vertical-align: top; width: 40%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
            <div style="font-size: 8pt;"><font style="font-size: 10pt; font-weight: bold;">Total</font><font style="font-size: 10pt;">:</font></div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 13%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
            <div>$</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 12%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
            <div>897,500</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 2%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">&#160;</td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
            <div>$</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" valign="bottom">
            <div>97.92</div>
          </td>
          <td colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" nowrap="nowrap" valign="bottom">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>
      <div>
        <div>
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                <td style="vertical-align: top; width: 27pt;">
                  <div style="text-align: justify;"><font style="font-family: 'Times New Roman',Times,serif;">(1)</font></div>
                </td>
                <td style="align: left; vertical-align: top; width: auto;">
                  <div style="text-align: justify;"><font style="font-family: 'Times New Roman',Times,serif;">Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the <font style="font-weight: bold; font-style: italic;">&#8220;Securities Act&#8221;</font>),






                      this Registration Statement shall also cover any additional shares of the Registrant&#8217;s common<font style="background-color: rgb(255, 255, 255); font-weight: normal; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;"> stock (&#8220;<font style="font-weight: bold; font-style: italic;">Common Stock</font>&#8221;) that become issuable under the plan set forth herein by reason of any stock dividend, stock split, recapitalization, or other
                        similar transaction ef</font>fected without receipt of consideration that increases the number of outstanding shares of the Registrant&#8217;s outstanding common stock, as applicable.</font></div>
                </td>
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          </table>
        </div>
        <div style="text-align: justify;"><font style="font-family: 'Times New Roman',Times,serif;"> <br>
          </font></div>
        <div>
          <div>
            <div>
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                    <td style="vertical-align: top; width: 27pt;">
                      <div><font style="text-align: justify; font-family: 'Times New Roman',Times,serif;">(2)</font></div>
                    </td>
                    <td style="align: left; vertical-align: top; width: auto;">
                      <div><font style="font-family: 'Times New Roman',Times,serif;">Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act. The offering price per share and
                          aggregate offering price are based on the average of the high and low prices of the Registrant&#8217;s Common Stock as reported on the Nasdaq Capital Market on May 19, 2021.</font></div>
                    </td>
                  </tr>

              </table>
            </div>
            <div><font style="font-weight: bold;"> <br>
              </font></div>
            <font style="font-weight: bold;"> </font>
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          </div>
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          <div style="text-align: center;"><font style="font-weight: bold;"></font><font style="font-weight: bold;">EXPLANATORY NOTE</font> </div>
        </div>
      </div>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 23pt; font-family: 'Times New Roman',Times,serif;">On May 19, 2021, Nuwellis, Inc (the <font style="font-weight: bold; font-style: italic;">&#8220;Company&#8221;</font> the<font style="font-weight: bold; font-style: italic;"> &#8220;Registrant</font>,<font style="font-weight: bold; font-style: italic;">&#8221;</font>&#160;<font style="font-weight: bold; font-style: italic;">&#8220;we</font>,<font style="font-weight: bold; font-style: italic;">&#8221; &#8220;us</font>,<font style="font-weight: bold; font-style: italic;">&#8221; or &#8220;our&#8221;</font>) adopted the Nuwellis, Inc. 2021 Inducement Plan (the &#8220;<font style="font-weight: bold; font-style: italic;">Inducement Plan</font>&#8221;), pursuant to which the Company reserved 250,000 shares of its common
      stock, par value $0.0001 per share (the <font style="font-weight: bold; font-style: italic;">&#8220;Common Stock&#8221;</font>) to be used exclusively for grants of equity-based awards to individuals who were not previously employees or directors of the
      Company, as an inducement material to the individual&#8217;s entry into employment with the Company within the meaning of Rule 5635(c)(4) of the Nasdaq Listing Rules. The Inducement Plan provides for the grant of equity-based awards in the form of
      nonstatutory stock options, restricted stock awards, restricted stock unit awards, performance stock awards, and other stock awards. The Inducement Plan was adopted by our board of directors without stockholder approval pursuant to Rule 5635(c)(4) of
      the Nasdaq Listing Rules.</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">PART I</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">INFORMATION REQUIRED IN PROSPECTUS</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">The information specified in Part I of Form S-8 is omitted from this Registration Statement in accordance with the provisions of Rule 428 under the
      Securities Act of 1933, as amended (the <font style="font-weight: bold; font-style: italic;">&#8220;Securities Act&#8221;</font>) and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I of Form S-8 will be
      delivered to the participants in the plan covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities Act.</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">PART II</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div><br>
    </div>
    <div>
      <div>
        <div>
          <table class="DSPFListTable" id="z84e6b8d69e8e4354af7a32d98842b262" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

              <tr style="vertical-align: top;">
                <td style="vertical-align: top; width: 36pt;">
                  <div style="text-align: left;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 3.</font></div>
                </td>
                <td style="align: left; vertical-align: top; width: auto;">
                  <div style="text-align: left;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">Incorporation of Documents by Reference.</font></div>
                </td>
              </tr>

          </table>
        </div>
      </div>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-family: 'Times New Roman',Times,serif;">(a)</font><font style="font-family: 'Times New Roman',Times,serif;"></font></div>
    <div style="margin: -12pt 0px 0px; text-align: justify; text-indent: 72pt;"><font style="font-family: 'Times New Roman',Times,serif;">The Registrant&#8217;s <a href="https://www.sec.gov/Archives/edgar/data/0001506492/000114036121009989/hc10021001x1_10k.htm"><u>Annual



            Report on Form 10-K</u></a> for the year ended December 31, 2020, filed with the Commission on March 25, 2021;</font></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-family: 'Times New Roman',Times,serif;">(b)</font>
      <div style="margin: -12pt 0px 0px; text-indent: 72pt;"><font style="font-family: 'Times New Roman',Times,serif;">The Registrant&#8217;s <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1506492/000114036121017219/brhc10024523_10q.htm"><u>Quarterly
              Report on Form 10-Q</u></a> for the quarter ended March 31, 2021, filed on May 13, 2021;</font></div>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-family: 'Times New Roman',Times,serif;">(c)</font>
      <div style="margin: -12pt 0px 0px; text-indent: 72pt;"><font style="font-family: 'Times New Roman',Times,serif;">The Registrant&#8217;s Current Reports on Form 8-K filed with the Commission on&#160;<a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036121001393/nc10019042x1_8k.htm"><u>January 19, 2021</u></a>, <a href="https://www.sec.gov/Archives/edgar/data/0001506492/000114036121005856/brhc10020746_8k.htm"><u>February 23, 2021</u></a>
          (as amended on <a href="https://www.sec.gov/Archives/edgar/data/0001506492/000114036121006202/brhc10020852_8ka.htm"><u>February 25, 2021</u></a>), <a href="https://www.sec.gov/Archives/edgar/data/0001506492/000114036121008900/nt10021708x2_8k.htm"><u>March 17, 2021</u></a>, <a href="https://www.sec.gov/Archives/edgar/data/0001506492/000114036121011643/brhc10022810_8k.htm"><u>April 5, 2021</u></a>,
          <a href="https://www.sec.gov/Archives/edgar/data/0001506492/000114036121014415/brhc10023443_8k.htm"><u>April 27, 2021</u></a> and <a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036121018200/brhc10024927_8k.htm">May 20, 2021</a>;
          and</font></div>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-family: 'Times New Roman',Times,serif;">(d)</font>
      <div style="margin: -12pt 0px 0px; text-indent: 72pt;"><font style="font-family: 'Times New Roman',Times,serif;">The description of the Registrant&#8217;s Common Stock contained in the Registration Statement on <a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465911054367/a11-26786_11012b.htm"><u>Form 10 (File No</u></a><u><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465911054367/a11-26786_11012b.htm">. 001-35312</a>)</u>
          filed pursuant to Section 12(b) on September 30, 2011 and all amendments thereto.</font></div>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">In addition, all documents the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as
      amended (the <font style="font-weight: bold; font-style: italic;">&#8220;Exchange Act&#8221;</font>), after the filing of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have
      been sold or which deregisters all securities covered hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part hereof from the date of filing of such documents. Notwithstanding anything herein, the
      Registrant is not incorporating by reference any information furnished under Item 2.02 or Item 7.01 of any Current Report on Form 8-K, unless, and to the extent, specified in any such Current Report on Form 8-K.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for
      purposes of this Registration Statement to the extent that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated by reference herein, modifies or supersedes such prior statement. Any such
      statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute part of this Registration Statement.</div>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">1</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
    </div>
    <div>
      <div>
        <table class="DSPFListTable" id="zb00143249e064490ab2cb6610db16ee1" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

            <tr style="vertical-align: top;">
              <td style="vertical-align: top; width: 36pt;">
                <div style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 4.</div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">Description of Securities.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">Not applicable.</div>
    <div><br>
    </div>
    <div>
      <div>
        <table class="DSPFListTable" id="zb838d1b52267470898d1efea0804444f" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

            <tr style="vertical-align: top;">
              <td style="vertical-align: top; width: 36pt;">
                <div style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 5.</div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">Interests of Named Experts and Counsel.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif;"> <br>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">Not applicable.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" class="DSPFListTable" id="z75eefc104f8f42beb14cfd91bab26416" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 6.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Indemnification of Directors and Officers.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">The Registrant&#8217;s Fourth Amended and Restated Certificate of Incorporation, as amended, limits the liability of the Registrant&#8217;s directors to the fullest
      extent permitted by Delaware law.&#160; Delaware law provides that directors of a corporation will not be personally liable for monetary damages for breach of their fiduciary duties as directors, except for liability for any:</div>
    <div><br>
    </div>
    <div>
      <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" class="DSPFListTable" id="z1bf13b086f2f4575b75114677ad4d670" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 54pt; vertical-align: top;">
              <div style="margin-left: 36pt; font-family: Symbol,serif;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">breach of their duty of loyalty to the Registrant or the Registrant&#8217;s stockholders;</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" class="DSPFListTable" id="z716069975ab44e8fa11ac4e242a7bfa4" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 54pt; vertical-align: top;">
              <div style="margin-left: 36pt; font-family: Symbol,serif;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" class="DSPFListTable" id="z9acb1527fb81418f8c42d22bd68eb311" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 54pt; vertical-align: top;">
              <div style="margin-left: 36pt; font-family: Symbol,serif;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">unlawful payment of dividends or redemption of shares as provided in Section 174 of the Delaware General Corporation Law (the <font style="font-weight: bold; font-style: italic;">&#8220;DGCL&#8221;</font>); or</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" class="DSPFListTable" id="z7e97fbfe40fd481bae99dd5bcee7b84c" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 54pt; vertical-align: top;">
              <div style="margin-left: 36pt; font-family: Symbol,serif;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">transaction from which the directors derived an improper personal benefit.</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">These limitations of liability do not apply to liabilities arising under federal securities laws and do not affect the availability of equitable remedies
      such as injunctive relief or rescission.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">The Registrant&#8217;s Third Amended and Restated Bylaws (the <font style="font-weight: bold; font-style: italic;">&#8220;Bylaws&#8221;</font>) provide that it will
      indemnify and advance expenses to its directors and officers to the fullest extent permitted by law or, if applicable, pursuant to indemnification agreements. The Bylaws further provide that the Registrant may choose to indemnify its other employees
      or agents from time to time. Subject to certain exceptions and procedures, the Bylaws also require it to advance to any person who was or is a party, or is threatened to be made a party, to any proceeding by reason of the person&#8217;s service as one of
      the Registrant&#8217;s directors or officers all expenses incurred by the person in connection with such proceeding.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">The Bylaws and Section 145(g) of the DGCL also permit it to secure insurance on behalf of any officer, director, employee or other agent for any liability
      arising out of his or her actions in connection with their services to us, regardless of whether the Bylaws permit indemnification. The Registrant maintains a directors&#8217; and officers&#8217; liability insurance policy.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">The Registrant entered into indemnification agreements with each of its directors and executive officers that provide, in general, that the Registrant will
      indemnify them to the fullest extent permitted by law in connection with their service to the Registrant or on its behalf and, subject to certain exceptions and procedures, that the Registrant will advance to them all expenses that they incur in
      connection with any proceeding to which they are, or are threatened to be, a party.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">At present, there is no pending litigation or proceeding involving any of the Registrant&#8217;s directors or officers as to which indemnification is required or
      permitted, and the Registrant is not aware of any threatened litigation or proceeding that may result in a claim for indemnification.</div>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">2</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0px; height: 2px; color: rgb(0, 0, 0); background-color: rgb(0, 0, 0); clear: both;" noshade="noshade"></div>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the
      registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission this indemnification is against public policy as expressed in the Securities Act and is
      therefore unenforceable.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" class="DSPFListTable" id="z73770b037db54f25b619c5e6b2abacfa" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 36pt; vertical-align: top; font-weight: bold;">Item 7.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-weight: bold;">Exemption from Registration Claimed.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">Not applicable.</div>
    <div><br>
      <div>
        <div>
          <table class="DSPFListTable" id="z7a4b8772ac1e48cc95353fac62588f0d" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" cellpadding="0" cellspacing="0">

              <tr style="vertical-align: top;">
                <td style="vertical-align: top; width: 36pt;">
                  <div style="text-align: left;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 8.</font></div>
                </td>
                <td style="align: left; vertical-align: top; width: auto;">
                  <div style="text-align: left;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">Exhibits.</font></div>
                </td>
              </tr>

          </table>
        </div>
      </div>
    </div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">EXHIBIT INDEX</div>
    <div><br>
    </div>
    <div style="text-align: justify; font-family: 'Times New Roman',Times,serif;">The following exhibits are filed as part of this registration statement.</div>
    <div><br>
    </div>
    <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" id="z83b179fedd6c47ae9850f4be03ce9402" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 7%; vertical-align: bottom; text-align: center; padding-bottom: 2px;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; text-align: center; padding-bottom: 2px;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: bottom; text-align: center; padding-bottom: 2px;">&#160;</td>
          <td colspan="3" style="vertical-align: bottom; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-weight: bold;">Incorporated By Reference</div>
          </td>
          <td style="width: 10.21%; vertical-align: bottom; text-align: center; padding-bottom: 2px;">&#160;</td>
          <td style="width: 10.47%; vertical-align: bottom; text-align: center; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top;">
            <div style="font-weight: bold;">Exhibit&#160; Number</div>
          </td>
          <td style="width: 2%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: bottom; text-align: center;">
            <div style="font-weight: bold;">Exhibit&#160; </div>
            <div style="font-weight: bold;">Description</div>
          </td>
          <td style="width: 8%; vertical-align: bottom; text-align: center;">
            <div style="font-weight: bold;">Form</div>
          </td>
          <td style="width: 9.86%; vertical-align: bottom; text-align: center;">
            <div style="font-weight: bold;">File&#160; </div>
            <div style="font-weight: bold;">Number</div>
          </td>
          <td style="width: 13%; vertical-align: bottom; text-align: center;">
            <div style="font-weight: bold;">Date of First </div>
            <div style="font-weight: bold;">Filing</div>
          </td>
          <td style="width: 10.21%; vertical-align: bottom; text-align: center;">
            <div style="font-weight: bold;">Exhibit </div>
            <div style="font-weight: bold;">Number</div>
          </td>
          <td style="width: 10.47%; vertical-align: bottom; text-align: center;">
            <div style="font-weight: bold;">Filed </div>
            <div style="font-weight: bold;">Herewith </div>
          </td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right; background-color: rgb(204, 238, 255);">
            <div>4.1</div>
          </td>
          <td style="width: 2%; vertical-align: top; text-align: right; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465912005820/a11-26786_1ex3d1.htm"><u>Fourth Amended and Restated Certificate of Incorporation</u></a></div>
          </td>
          <td style="width: 8%; vertical-align: top; text-align: center; background-color: rgb(204, 238, 255);">
            <div>10</div>
          </td>
          <td style="width: 9.86%; vertical-align: top; text-align: center; background-color: rgb(204, 238, 255);">
            <div>001-35312</div>
          </td>
          <td style="width: 13%; vertical-align: top; text-align: center; background-color: rgb(204, 238, 255);">
            <div>February 1, 2012</div>
          </td>
          <td style="width: 10.21%; vertical-align: top; text-align: center; background-color: rgb(204, 238, 255);">
            <div>3.1</div>
          </td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="width: 2%; vertical-align: top; text-align: right;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036117038508/ex3_1.htm"><u>Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation</u></a></div>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036119000021/s002610x2_ex3-1.htm"><u>Certificate of Amendment to Fourth Amended a</u><u>nd Restated Certificate of Incorporation</u></a></div>
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          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036120023203/brhc10016044_ex3-1.htm"><u>Certificate of Amendment to Fourth Amended</u><u> and Restated Certificate of Incorporation</u></a></div>
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            <div>001-35312</div>
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          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036121014415/brhc10023443_ex3-1.htm"><u>Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation</u></a></div>
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            <div>001-35312</div>
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          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465917034447/a17-13940_1ex3d2.htm"><u>Second Amended and Restated Bylaws</u></a></div>
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            <div>8-K</div>
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            <div>001-35312</div>
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            <div>April 27, 2021</div>
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          <td style="width: 10.21%; vertical-align: top; text-align: center; background-color: rgb(204, 238, 255);">
            <div>3.2</div>
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          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="width: 2%; vertical-align: top; text-align: right;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465913049339/a13-14837_1ex3d1.htm"><u>Form of Certifi</u><u>cate of Designation of Series A Junior Participating Preferred Stock</u></a></div>
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            <div>8-K</div>
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          <td style="width: 9.86%; vertical-align: top; text-align: center; background-color: rgb(204, 238, 255);">
            <div>001-35312</div>
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          <td style="width: 10.21%; vertical-align: top; text-align: center; background-color: rgb(204, 238, 255);">
            <div>3.1</div>
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          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
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          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="width: 2%; vertical-align: top; text-align: right;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
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          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000156761917002350/s001918x7_ex3-7.htm"><u>Form of Certificate of Designation of Preferenc</u><u>es, </u><u>Rights and Limitations of Series F Convertible Preferred Stock</u></a></div>
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            <div>333-221010</div>
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          <td style="width: 10.21%; vertical-align: top; text-align: center; background-color: rgb(204, 238, 255);">
            <div>3.7</div>
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            <div>001-35312</div>
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          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div>5.1</div>
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          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="nt10024904x1_ex5-1.htm">Opinion of Honigman LLP</a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>23.1</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="nt10024904x1_ex23-1.htm">Consent of Baker Tilly US, LLP</a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>23.2</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="nt10024904x1_ex5-1.htm">Consent of Honigman LLP</a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>Included in Exhibit 5.1</div>
          </td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>24</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="#sig">Power of Attorney (included on signature page)</a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>99.1</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465913027169/a13-9388_1def14a.htm#AppendixA_073656"><u>2013 Non</u><u>-Employee Directors&#8217; Equity Incentive Plan</u>&#8224;</a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>14A</div>
          </td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>001-35312</div>
          </td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>April 5, 2013</div>
          </td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>App. A</div>
          </td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>99.2</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465913061733/a13-13918_1ex10d1.htm"><u>New-Hire </u><u>Equity In</u><u>centive Plan</u>&#8224;</a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>10-Q</div>
          </td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>001-35312</div>
          </td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>August 8, 2013</div>
          </td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>10.1</div>
          </td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>99.3</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465913083328/a13-19758_1ex10d1.htm"><u>First</u><u> Amendment to New-Hire Equity Incentive Plan</u>&#8224;</a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>10-Q</div>
          </td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>001-35312</div>
          </td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>November 12, 2013</div>
          </td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>10.1</div>
          </td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>99.4</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465915021399/a15-7344_1ex99d12.htm"><u>Second</u><u> Amendment to New-Hire Equity Incentive Plan</u>&#8224;</a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>S-8</div>
          </td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>333-202904</div>
          </td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>March 20, 2015</div>
          </td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>99.12</div>
          </td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>99.5</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465916105225/a16-6324_1ex99d13.htm"><u>Third A</u><u>mendment to New-Hire Equity Incentive Plan</u>&#8224;</a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>S-8</div>
          </td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>333-210215</div>
          </td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>March 15, 2016</div>
          </td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>99.13</div>
          </td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>99.6</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465917036171/a17-14346_1ex10d4.htm"><u>Fourth A</u><u>mendment to New-Hire Equity Incentive Plan</u>&#8224;</a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>8-K</div>
          </td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>001-35312</div>
          </td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>May 30, 2017</div>
          </td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>10.4</div>
          </td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>99.7</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036118002414/s002025x1_ex10-1.htm"><u>Fifth A</u><u>men</u><u>dment to New-Hire Equity Incentive Plan&#8224;</u></a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>8-K</div>
          </td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>001-35312</div>
          </td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>January 18, 2018</div>
          </td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>10.1</div>
          </td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.47%; vertical-align: top; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">
            <div>99.8</div>
          </td>
          <td style="vertical-align: top; background-color: rgb(204, 238, 255); text-align: right; width: 2%;" colspan="1">&#160;</td>
          <td style="width: 40%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036119014608/ex10_2.htm"><u>Sixth Amendment to New-Hire Equity I</u><u>ncentive Plan</u><u>&#8224;</u></a></div>
          </td>
          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>10-Q</div>
          </td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>001-35312</div>
          </td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>August 8, 2019</div>
          </td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">
            <div>10.2</div>
          </td>
          <td style="width: 10.47%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
          <td style="vertical-align: top; text-align: right; width: 2%;" colspan="1">&#160;</td>
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          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036119022090/nc10006740x1_ex10-1.htm"><u>Seventh </u><u>Amendment to New-Hire Equity Incentive Plan</u><u>&#8224;</u></a></div>
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            <div>001-35312</div>
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          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
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          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
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          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036121005856/brhc10020746_10-1.htm"><u>Eighth Amendment to New-Hire Equity Incentive Plan</u><u>&#8224;</u></a></div>
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            <div>001-35312</div>
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          <td style="width: 7%; vertical-align: top; text-align: right;">&#160;</td>
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          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000110465917036171/a17-14346_1ex10d1.htm"><u>2017 Equity </u><u>Incentive Plan</u>&#8224;</a></div>
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          <td style="width: 9.86%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="https://www.sec.gov/Archives/edgar/data/1506492/000114036120020186/nc10014736x3_def14a.htm#tAA"><u>First Amendment </u><u>to the CHF Solutions, Inc. 2</u><u>017 Equity Incentive Plan&#8224;</u></a></div>
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            <div>001-35312</div>
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          <td style="width: 13%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; text-align: center;">&#160;</td>
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            <div><a href="nt10024904x1_ex99-13.htm"><u>Nuwellis, Inc. 2021 Inducement Plan</u></a></div>
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          <td style="width: 8%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 9.86%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
          <td style="width: 10.21%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: center;">&#160;</td>
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                  <div style="text-align: justify;">To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:</div>
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    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;"> <a name="sig"><!--Anchor--><br>
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    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-weight: bold;">SIGNATURES</div>
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    <div style="text-align: justify; font-family: 'Times New Roman',Times,serif;">Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
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            <div>NUWELLIS, INC.</div>
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            <div>By:</div>
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            <div>/s/ <font style="font-variant: small-caps;">Nestor Jaramillo</font></div>
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            <div>Nestor Jaramillo</div>
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            <div>President and Chief Executive Officer</div>
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        </tr>

    </table>
    <div><br>
    </div>
    <div><font style="font-family: 'Times New Roman',Times,serif;">We, the undersigned officers and directors of Nuwellis, Inc., hereby constitute Nestor Jaramillo, as the true and lawful attorney with full power to sign for us and in our names, in the
        capacities indicated below the Registration Statement filed herewith and any amendments to said Registration Statement, and generally to do all such things in our name and behalf in our capacities as officers and directors to enable Nuwellis, Inc.
        to comply with the provisions of the Securities Act of 1933 and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said
        Registration Statement and any and all amendments thereto.&#160; Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</font></div>
    <div><font style="font-family: 'Times New Roman',Times,serif;"> <br>
      </font></div>
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        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div style="text-align: center;"><u>SIGNATURE</u></div>
          </td>
          <td style="width: 40%; vertical-align: top;">
            <div style="text-align: center;"><u>TITLE</u></div>
          </td>
          <td style="width: 30%; vertical-align: top;">
            <div style="text-align: center;"><u>DATE</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Nestor Jaramillo</font></div>
          </td>
          <td style="width: 40%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">President, CEO, Interim CFO, and Chairman</div>
          </td>
          <td style="width: 30%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">May 24, 2021</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Nestor Jaramillo</div>
          </td>
          <td style="width: 40%; vertical-align: top;">
            <div style="text-align: center;">(principal executive officer and principal financial officer)</div>
          </td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Paul Wotta</font></div>
          </td>
          <td style="width: 40%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Controller</div>
          </td>
          <td style="width: 30%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">May 24, 2021</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Paul Wotta</div>
          </td>
          <td style="width: 40%; vertical-align: top;">
            <div style="text-align: center;">(principal accounting officer)</div>
          </td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Steve Brandt</font></div>
          </td>
          <td style="width: 40%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 30%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">May 24, 2021</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Steve Brandt</div>
          </td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Maria Rosa Costanzo</font></div>
          </td>
          <td style="width: 40%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 30%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">May 24, 2021</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Maria Rosa Costanzo</div>
          </td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">John L. Erb</font></div>
          </td>
          <td style="width: 40%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 30%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">May 24, 2021</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>John L. Erb</div>
          </td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Jon W. Salveson</font></div>
          </td>
          <td style="width: 40%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 30%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">May 24, 2021</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Jon W. Salveson</div>
          </td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Gregory D. Waller</font></div>
          </td>
          <td style="width: 40%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 30%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">May 24, 2021</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Gregory D. Waller</div>
          </td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ <font style="font-variant: small-caps;">Warren S. Watson</font></div>
          </td>
          <td style="width: 40%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">Director</div>
          </td>
          <td style="width: 30%; vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center;">May 24, 2021</div>
          </td>
        </tr>
        <tr>
          <td style="width: 30%; vertical-align: top;">
            <div>Warren S. Watson</div>
          </td>
          <td style="width: 40%; vertical-align: top;">&#160;</td>
          <td style="width: 30%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div><br>
    </div>
    <div>
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman'; font-size: 8pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">6</font></div>
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{"company-data": {"conformed-name": "Nuwellis, Inc.", "cik": "0001506492", "assigned-sic": "3845", "irs-number": "680533453", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "S-8", "act": "33", "file-number": "333-256432", "film-number": "21954866"}, "business-address": {"street1": "12988 VALLEY VIEW ROAD", "city": "EDEN PRAIRIE", "state": "MN", "zip": "55344", "phone": "952-345-4200"}, "mail-address": {"street1": "12988 VALLEY VIEW ROAD", "city": "EDEN PRAIRIE", "state": "MN", "zip": "55344"}, "former-company": [{"former-conformed-name": "CHF Solutions, Inc.", "date-changed": "20170523"}, {"former-conformed-name": "Sunshine Heart, Inc.", "date-changed": "20101124"}]}
As filed with the Securities and Exchange Commission on May 24, 2021
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Nuwellis, Inc.
(Exact name of registrant as specified in its charter)
Delaware
68-0533453
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer Identification No.)
12988 Valley View Road
Eden Prairie, Minnesota
55344
(Address of Principal Executive Offices)
(Zip Code)
Nuwellis, Inc. 2021 Inducement Plan
(Full title of the plan)
Nestor Jaramillo
Chief Executive Officer
Nuwellis, Inc.
12988 Valley View Road
Eden Prairie, MN 55344
(952) 345-4200
(Name, address and telephone number, including area code, of agent for service)
Copy to:
Phillip D. Torrence, Esq.
Honigman LLP
650 Trade Center Way, Ste 200
Kalamazoo, MI 49002
(269) 337-7700
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the
      definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.
Large accelerated filer  ☐   Accelerated filer  ☐
Non-accelerated filer  ☒   Smaller reporting company  ☒
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
      provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
CALCULATION OF REGISTRATION FEE
Title of securities to be registered
Amount to be
Registered (1)
Proposed maximum
offering price
per share
Proposed maximum
aggregate offering
price
Amount of
registration
fee
Common Stock, par value $0.0001 per share
Nuwellis, Inc. 2021 Inducement Plan
250,000
$
3.59
(2)
$
897,500
(2)
$
97.92
Total
:
$
897,500
$
97.92
(1)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the
"Securities Act"
),

                      this Registration Statement shall also cover any additional shares of the Registrant's common
stock ("
Common Stock
") that become issuable under the plan set forth herein by reason of any stock dividend, stock split, recapitalization, or other
                        similar transaction ef
fected without receipt of consideration that increases the number of outstanding shares of the Registrant's outstanding common stock, as applicable.
(2)
Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act. The offering price per share and
                          aggregate offering price are based on the average of the high and low prices of the Registrant's Common Stock as reported on the Nasdaq Capital Market on May 19, 2021.
EXPLANATORY NOTE
On May 19, 2021, Nuwellis, Inc (the
"Company"
the
"Registrant
,
"
"we
,
" "us
,
" or "our"
) adopted the Nuwellis, Inc. 2021 Inducement Plan (the "
Inducement Plan
"), pursuant to which the Company reserved 250,000 shares of its common
      stock, par value $0.0001 per share (the
"Common Stock"
) to be used exclusively for grants of equity-based awards to individuals who were not previously employees or directors of the
      Company, as an inducement material to the individual's entry into employment with the Company within the meaning of Rule 5635(c)(4) of the Nasdaq Listing Rules. The Inducement Plan provides for the grant of equity-based awards in the form of
      nonstatutory stock options, restricted stock awards, restricted stock unit awards, performance stock awards, and other stock awards. The Inducement Plan was adopted by our board of directors without stockholder approval pursuant to Rule 5635(c)(4) of
      the Nasdaq Listing Rules.
PART I
INFORMATION REQUIRED IN PROSPECTUS
The information specified in Part I of Form S-8 is omitted from this Registration Statement in accordance with the provisions of Rule 428 under the
      Securities Act of 1933, as amended (the
"Securities Act"
) and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I of Form S-8 will be
      delivered to the participants in the plan covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities Act.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.
Incorporation of Documents by Reference.
The following documents filed with the Commission by the Registrant are hereby incorporated by reference in this Registration Statement:
(a)
The Registrant's
Annual

            Report on Form 10-K
for the year ended December 31, 2020, filed with the Commission on March 25, 2021;
(b)
The Registrant's
Quarterly
              Report on Form 10-Q
for the quarter ended March 31, 2021, filed on May 13, 2021;
(c)
The Registrant's Current Reports on Form 8-K filed with the Commission on
January 19, 2021
,
February 23, 2021
(as amended on
February 25, 2021
),
March 17, 2021
,
April 5, 2021
,
April 27, 2021
and
May 20, 2021
;
          and
(d)
The description of the Registrant's Common Stock contained in the Registration Statement on
Form 10 (File No
. 001-35312
)
filed pursuant to Section 12(b) on September 30, 2011 and all amendments thereto.
In addition, all documents the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as
      amended (the
"Exchange Act"
), after the filing of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have
      been sold or which deregisters all securities covered hereby then remaining unsold are incorporated by reference in this Registration Statement and are a part hereof from the date of filing of such documents. Notwithstanding anything herein, the
      Registrant is not incorporating by reference any information furnished under Item 2.02 or Item 7.01 of any Current Report on Form 8-K, unless, and to the extent, specified in any such Current Report on Form 8-K.
Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for
      purposes of this Registration Statement to the extent that a statement contained herein, or in any subsequently filed document, which also is or is deemed to be incorporated by reference herein, modifies or supersedes such prior statement. Any such
      statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute part of this Registration Statement.
1
Item 4.
Description of Securities.
Not applicable.
Item 5.
Interests of Named Experts and Counsel.
Not applicable.
Item 6.
Indemnification of Directors and Officers.
The Registrant's Fourth Amended and Restated Certificate of Incorporation, as amended, limits the liability of the Registrant's directors to the fullest
      extent permitted by Delaware law.  Delaware law provides that directors of a corporation will not be personally liable for monetary damages for breach of their fiduciary duties as directors, except for liability for any:
•
breach of their duty of loyalty to the Registrant or the Registrant's stockholders;
•
act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;
•
unlawful payment of dividends or redemption of shares as provided in Section 174 of the Delaware General Corporation Law (the
"DGCL"
); or
•
transaction from which the directors derived an improper personal benefit.
These limitations of liability do not apply to liabilities arising under federal securities laws and do not affect the availability of equitable remedies
      such as injunctive relief or rescission.
The Registrant's Third Amended and Restated Bylaws (the
"Bylaws"
) provide that it will
      indemnify and advance expenses to its directors and officers to the fullest extent permitted by law or, if applicable, pursuant to indemnification agreements. The Bylaws further provide that the Registrant may choose to indemnify its other employees
      or agents from time to time. Subject to certain exceptions and procedures, the Bylaws also require it to advance to any person who was or is a party, or is threatened to be made a party, to any proceeding by reason of the person's service as one of
      the Registrant's directors or officers all expenses incurred by the person in connection with such proceeding.
The Bylaws and Section 145(g) of the DGCL also permit it to secure insurance on behalf of any officer, director, employee or other agent for any liability
      arising out of his or her actions in connection with their services to us, regardless of whether the Bylaws permit indemnification. The Registrant maintains a directors' and officers' liability insurance policy.
The Registrant entered into indemnification agreements with each of its directors and executive officers that provide, in general, that the Registrant will
      indemnify them to the fullest extent permitted by law in connection with their service to the Registrant or on its behalf and, subject to certain exceptions and procedures, that the Registrant will advance to them all expenses that they incur in
      connection with any proceeding to which they are, or are threatened to be, a party.
At present, there is no pending litigation or proceeding involving any of the Registrant's directors or officers as to which indemnification is required or
      permitted, and the Registrant is not aware of any threatened litigation or proceeding that may result in a claim for indemnification.
2
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the
      registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission this indemnification is against public policy as expressed in the Securities Act and is
      therefore unenforceable.
Item 7.
Exemption from Registration Claimed.
Not applicable.
Item 8.
Exhibits.
EXHIBIT INDEX
The following exhibits are filed as part of this registration statement.
Incorporated By Reference
Exhibit  Number
Exhibit
Description
Form
File
Number
Date of First
Filing
Exhibit
Number
Filed
Herewith
4.1
Fourth Amended and Restated Certificate of Incorporation
10
001-35312
February 1, 2012
3.1
4.2
Certificate of Amendment to the Fourth Amended and Restated Certificate of Incorporation
8-K
001-35312
January 13, 2017
3.1
4.3
Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation
8-K
001-35312
May 23, 2017
3.1
4.4
Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation
8-K
001-35312
October 12, 2017
3.1
4.5
Certificate of Amendment to Fourth Amended a
nd Restated Certificate of Incorporation
8-K
001-35312
January 2, 2019
3.1
4.6
Certificate of Amendment to Fourth Amended
and Restated Certificate of Incorporation
8-K/A
001-35312
October 16, 2020
3.1
4.7
Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation
8-K
001-35312
April 27, 2021
3.1
4.8
Second Amended and Restated Bylaws
8-K
001-35312
April 27, 2021
3.2
4.9
Form of Certifi
cate of Designation of Series A Junior Participating Preferred Stock
8-K
001-35312
June 14, 2013
3.1
4.10
Form of Certificate of Designation of Preferenc
es,
Rights and Limitations of Series F Convertible Preferred Stock
S-1/A
333-221010
November 17, 2017
3.7
3
Incorporated By Reference
Exhibit  Number
Exhibit
Description
Form
File
Number
Date of First
Filing
Exhibit
Number
Filed
Herewith
4.11
Registration Rights Agreement between Sunshine Heart, Inc. and Gambro UF
Solutions, Inc. dated August 5, 2016
8-K
001-35312
August 8, 2016
4.1
5.1
Opinion of Honigman LLP
X
23.1
Consent of Baker Tilly US, LLP
X
23.2
Consent of Honigman LLP
Included in Exhibit 5.1
24
Power of Attorney (included on signature page)
X
99.1
2013 Non
-Employee Directors' Equity Incentive Plan
†
14A
001-35312
April 5, 2013
App. A
99.2
New-Hire
Equity In
centive Plan
†
10-Q
001-35312
August 8, 2013
10.1
99.3
First
Amendment to New-Hire Equity Incentive Plan
†
10-Q
001-35312
November 12, 2013
10.1
99.4
Second
Amendment to New-Hire Equity Incentive Plan
†
S-8
333-202904
March 20, 2015
99.12
99.5
Third A
mendment to New-Hire Equity Incentive Plan
†
S-8
333-210215
March 15, 2016
99.13
99.6
Fourth A
mendment to New-Hire Equity Incentive Plan
†
8-K
001-35312
May 30, 2017
10.4
99.7
Fifth A
men
dment to New-Hire Equity Incentive Plan†
8-K
001-35312
January 18, 2018
10.1
99.8
Sixth Amendment to New-Hire Equity I
ncentive Plan
†
10-Q
001-35312
August 8, 2019
10.2
99.9
Seventh
Amendment to New-Hire Equity Incentive Plan
†
8-K
001-35312
December 6, 2019
10.1
99.10
Eighth Amendment to New-Hire Equity Incentive Plan
†
8-K
001-35312
February 23, 2021
10.1
99.11
2017 Equity
Incentive Plan
†
8-K
001-35312
May 30, 2017
10.1
99.12
First Amendment
to the CHF Solutions, Inc. 2
017 Equity Incentive Plan†
14A
001-35312
September 11, 2020
App. A
99.13
Nuwellis, Inc. 2021 Inducement Plan
X
†
Indicates management compensatory plan, contract or arrangement.
4
Item 9.
Undertakings.
(a)
The Registrant hereby undertakes:
(1)
To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
(i)
To include any prospectus required by Section 10(a)(3) of the Securities Act;
(ii)
To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which,
                      individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement.  Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
                      value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant
                      to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective
                      Registration Statement;
(iii)
To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in
                      the Registration Statement;
provided, however,
that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a
      post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in the Registration
      Statement; and
(2)
That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the
                      securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(3)
To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(b)
The Registrant hereby undertakes that, for the purposes of determining any liability under the Securities Act, each filing of the
      Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference
      in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c)
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and
      controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is,
      therefore, unenforceable.  In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful
      defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by
      controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
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SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for
      filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Eden Prairie, State of Minnesota, on May 24, 2021.
NUWELLIS, INC.
By:
/s/
Nestor Jaramillo
Name:
Nestor Jaramillo
Title:
President and Chief Executive Officer
We, the undersigned officers and directors of Nuwellis, Inc., hereby constitute Nestor Jaramillo, as the true and lawful attorney with full power to sign for us and in our names, in the
        capacities indicated below the Registration Statement filed herewith and any amendments to said Registration Statement, and generally to do all such things in our name and behalf in our capacities as officers and directors to enable Nuwellis, Inc.
        to comply with the provisions of the Securities Act of 1933 and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said
        Registration Statement and any and all amendments thereto.  Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
SIGNATURE
TITLE
DATE
/s/
Nestor Jaramillo
President, CEO, Interim CFO, and Chairman
May 24, 2021
Nestor Jaramillo
(principal executive officer and principal financial officer)
/s/
Paul Wotta
Controller
May 24, 2021
Paul Wotta
(principal accounting officer)
/s/
Steve Brandt
Director
May 24, 2021
Steve Brandt
/s/
Maria Rosa Costanzo
Director
May 24, 2021
Maria Rosa Costanzo
/s/
John L. Erb
Director
May 24, 2021
John L. Erb
/s/
Jon W. Salveson
Director
May 24, 2021
Jon W. Salveson
/s/
Gregory D. Waller
Director
May 24, 2021
Gregory D. Waller
/s/
Warren S. Watson
Director
May 24, 2021
Warren S. Watson
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