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        <filer>
          <filerCredentials>
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            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
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        <issuerCik>0001704292</issuerCik>
        <issuerName>Zai Lab Ltd</issuerName>
        <secFileNumber>001-38205</secFileNumber>
        <issuerAddress>
          <com:street1>4560 JINKE ROAD</com:street1>
          <com:street2>BLDG. 1, 4F, PUDONG</com:street2>
          <com:city>SHANGHAI</com:city>
          <com:stateOrCountry>F4</com:stateOrCountry>
          <com:zipCode>201210</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>862161632588</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Edmondson Frazor Titus III</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
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      <securitiesInformation>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>4803</noOfUnitsSold>
        <aggregateMarketValue>125463.49</aggregateMarketValue>
        <noOfUnitsOutstanding>754401320</noOfUnitsOutstanding>
        <approxSaleDate>01/03/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <acquiredDate>01/02/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4803</amountOfSecuritiesAcquired>
        <paymentDate>01/02/2024</paymentDate>
        <natureOfPayment>NASDAQ</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>01/03/2024</noticeDate>
        <signature>/s/ Bradley Camilo, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Frazor T. Edmondson</signature>
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text: 144
  0001835780
  XXXXXXXX
  LIVE
  0001704292
  Zai Lab Ltd
  001-38205
  4560 JINKE ROAD
  BLDG. 1, 4F, PUDONG
  SHANGHAI
  F4
  201210
  862161632588
  Edmondson Frazor Titus III
  Officer
  American Depositary Shares
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  4803
  125463.49
  754401320
  01/03/2024
  NASDAQ
  American Depositary Shares
  01/02/2024
  Restricted Stock Vesting
  Issuer
  N
  4803
  01/02/2024
  NASDAQ
  Y
  01/03/2024
  /s/ Bradley Camilo, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Frazor T. Edmondson