content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001307313</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001162194</issuerCik>
        <issuerName>STANDARD BIOTOOLS INC.</issuerName>
        <secFileNumber>001-34180</secFileNumber>
        <issuerAddress>
          <com:street1>2 TOWER PLACE</com:street1>
          <com:street2>SUITE 2000</com:street2>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>6502666000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Burbach Gerhard F</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>42571</noOfUnitsSold>
        <aggregateMarketValue>113665.39</aggregateMarketValue>
        <noOfUnitsOutstanding>78964770</noOfUnitsOutstanding>
        <approxSaleDate>08/23/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/23/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Options Granted - 06/15/2022</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>42571</amountOfSecuritiesAcquired>
        <paymentDate>08/23/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Gerhard F. Burbach</name>
          <address>
            <com:street1>2 Tower Place</com:street1>
            <com:street2>Suite 2000</com:street2>
            <com:city>South San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>08/17/2023</saleDate>
        <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
        <grossProceeds>40404.01</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>08/23/2023</noticeDate>
        <signature>/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Gerhard F. Burbach</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3536}]
text: 144
  0001307313
  XXXXXXXX
  LIVE
  0001162194
  STANDARD BIOTOOLS INC.
  001-34180
  2 TOWER PLACE
  SUITE 2000
  SOUTH SAN FRANCISCO
  CA
  94080
  6502666000
  Burbach Gerhard F
  Former Director
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  42571
  113665.39
  78964770
  08/23/2023
  NASDAQ
  Common
  08/23/2023
  Options Granted - 06/15/2022
  Issuer
  N
  42571
  08/23/2023
  Cash
  N
  Gerhard F. Burbach
  2 Tower Place
  Suite 2000
  South San Francisco
  CA
  94080
  Common
  08/17/2023
  15000
  40404.01
  08/23/2023
  /s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Gerhard F. Burbach