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        <secFileNumber>001-39421</secFileNumber>
        <issuerAddress>
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          <com:city>NEW HOPE</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>18938</com:zipCode>
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        <issuerContactPhone>646-343-9298</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sherman Darren</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
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        <securitiesClassTitle>Common</securitiesClassTitle>
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          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
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        <noOfUnitsOutstanding>37824571</noOfUnitsOutstanding>
        <approxSaleDate>09/10/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
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        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6904</amountOfSecuritiesAcquired>
        <paymentDate>09/09/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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          <name>Darren Sherman</name>
          <address>
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            <com:city>New Hope</com:city>
            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>18938</com:zipCode>
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        <securitiesClassTitle>Common</securitiesClassTitle>
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        <amountOfSecuritiesSold>6837</amountOfSecuritiesSold>
        <grossProceeds>41702.28</grossProceeds>
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        <sellerDetails>
          <name>Darren Sherman</name>
          <address>
            <com:street1>150 Union Square Drive</com:street1>
            <com:city>New Hope</com:city>
            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>18938</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/05/2024</saleDate>
        <amountOfSecuritiesSold>6961</amountOfSecuritiesSold>
        <grossProceeds>40708.62</grossProceeds>
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          <name>Darren Sherman</name>
          <address>
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            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>18938</com:zipCode>
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        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/06/2024</saleDate>
        <amountOfSecuritiesSold>6819</amountOfSecuritiesSold>
        <grossProceeds>38513.03</grossProceeds>
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            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>18938</com:zipCode>
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        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/09/2024</saleDate>
        <amountOfSecuritiesSold>6804</amountOfSecuritiesSold>
        <grossProceeds>37319.26</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>09/10/2024</noticeDate>
        <signature>/s/ Gary Redman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Darren Sherman</signature>
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text: 144
  0001723524
  XXXXXXXX
  LIVE
  0001814114
  Orchestra BioMed Holdings, Inc.
  001-39421
  150 UNION SQUARE DRIVE
  NEW HOPE
  PA
  18938
  646-343-9298
  Sherman Darren
  Officer
  Director
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  6904
  36647.12
  37824571
  09/10/2024
  NASDAQ
  Common
  09/09/2024
  Restricted Stock Vesting
  Issuer
  N
  6904
  09/09/2024
  Compensation
  N
  Darren Sherman
  150 Union Square Drive
  New Hope
  PA
  18938
  Common
  09/04/2024
  6837
  41702.28
  Darren Sherman
  150 Union Square Drive
  New Hope
  PA
  18938
  Common
  09/05/2024
  6961
  40708.62
  Darren Sherman
  150 Union Square Drive
  New Hope
  PA
  18938
  Common
  09/06/2024
  6819
  38513.03
  Darren Sherman
  150 Union Square Drive
  New Hope
  PA
  18938
  Common
  09/09/2024
  6804
  37319.26
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  09/10/2024
  /s/ Gary Redman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Darren Sherman