content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001628970</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001427925</issuerCik>
        <issuerName>TALPHERA, INC.</issuerName>
        <secFileNumber>001-35068</secFileNumber>
        <issuerAddress>
          <com:street1>1850 GATEWAY DRIVE</com:street1>
          <com:street2>SUITE 175</com:street2>
          <com:city>SAN MATEO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94404</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>650-216-3500</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ASADORIAN RAFFI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>FIDELITY BROKERAGE SERVICES LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>BOSTON</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>155</noOfUnitsSold>
        <aggregateMarketValue>107.00</aggregateMarketValue>
        <noOfUnitsOutstanding>17029218</noOfUnitsOutstanding>
        <approxSaleDate>12/02/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/14/2018</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>OPEN MARKET</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>155</amountOfSecuritiesAcquired>
        <paymentDate>12/14/2018</paymentDate>
        <natureOfPayment>Cash/Check</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/02/2024</noticeDate>
        <signature>/s/ Jordyn Davis as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for ASADORIAN RAFFI </signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2862}]
text: 144
  0001628970
  XXXXXXXX
  LIVE
  0001427925
  TALPHERA, INC.
  001-35068
  1850 GATEWAY DRIVE
  SUITE 175
  SAN MATEO
  CA
  94404
  650-216-3500
  ASADORIAN RAFFI
  Officer
  Common
  FIDELITY BROKERAGE SERVICES LLC
  245 Summer Street
  BOSTON
  MA
  02110
  155
  107.00
  17029218
  12/02/2024
  NASDAQ
  Common
  12/14/2018
  Open Market Purchase
  OPEN MARKET
  N
  155
  12/14/2018
  Cash/Check
  Y
  12/02/2024
  /s/ Jordyn Davis as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for ASADORIAN RAFFI