content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001880973</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001645569</issuerCik>
        <issuerName>DICE THERAPEUTICS, INC.</issuerName>
        <secFileNumber>001-40794</secFileNumber>
        <issuerAddress>
          <com:street1>400 East Jamie Court,</com:street1>
          <com:city>South San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>6505661420</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Timothy Lu</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>360 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>20000</noOfUnitsSold>
        <aggregateMarketValue>687800</aggregateMarketValue>
        <noOfUnitsOutstanding>47711123</noOfUnitsOutstanding>
        <approxSaleDate>05/03/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/14/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Stock option exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>20000</amountOfSecuritiesAcquired>
        <paymentDate>09/14/2021</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/03/2023</noticeDate>
        <signature>/s/ JPMS LLC as agent and attorney-in-fact for Timothy Lu</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2799}]
text: 144
  0001880973
  XXXXXXXX
  LIVE
  0001645569
  DICE THERAPEUTICS, INC.
  001-40794
  400 East Jamie Court,
  South San Francisco
  CA
  94080
  6505661420
  Timothy Lu
  affiliate
  common
  J.P. Morgan Securities LLC
  360 Madison Avenue - 6th Floor
  New York
  NY
  10017
  20000
  687800
  47711123
  05/03/2023
  Nasdaq
  Common
  09/14/2021
  Stock option exercise
  Issuer
  N
  20000
  09/14/2021
  Cash
  Y
  05/03/2023
  /s/ JPMS LLC as agent and attorney-in-fact for Timothy Lu