content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0000929985</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001369568</issuerCik>
        <issuerName>CATALYST PHARMACEUTICALS, INC.</issuerName>
        <secFileNumber>001-33057</secFileNumber>
        <issuerAddress>
          <com:street1>355 ALHAMBRA CIRCLE</com:street1>
          <com:street2>SUITE 801</com:street2>
          <com:city>CORAL GABLES</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33134</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(305) 529-2522</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MCENANY PATRICK J</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>44655</noOfUnitsSold>
        <aggregateMarketValue>971327.03</aggregateMarketValue>
        <noOfUnitsOutstanding>119273436</noOfUnitsOutstanding>
        <approxSaleDate>11/14/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>11/14/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted - 05/29/2018</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>44655</amountOfSecuritiesAcquired>
        <paymentDate>11/14/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Patrick Mcenany</name>
          <address>
            <com:street1>355 Alhambra Circle Suite 801</com:street1>
            <com:city>Coral Gables</com:city>
            <com:stateOrCountry>FL</com:stateOrCountry>
            <com:zipCode>33134</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>11/11/2024</saleDate>
        <amountOfSecuritiesSold>230000</amountOfSecuritiesSold>
        <grossProceeds>5416008.48</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Patrick Mcenany</name>
          <address>
            <com:street1>355 Alhambra Circle Suite 801</com:street1>
            <com:city>Coral Gables</com:city>
            <com:stateOrCountry>FL</com:stateOrCountry>
            <com:zipCode>33134</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>11/12/2024</saleDate>
        <amountOfSecuritiesSold>262000</amountOfSecuritiesSold>
        <grossProceeds>6094084.20</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Patrick Mcenany</name>
          <address>
            <com:street1>355 Alhambra Circle Suite 801</com:street1>
            <com:city>Coral Gables</com:city>
            <com:stateOrCountry>FL</com:stateOrCountry>
            <com:zipCode>33134</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>11/13/2024</saleDate>
        <amountOfSecuritiesSold>92500</amountOfSecuritiesSold>
        <grossProceeds>2125996.50</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/14/2024</noticeDate>
        <signature>/s/ Tyler Johnson, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Patrick Mcenany</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4701}]
text: 144
  0000929985
  XXXXXXXX
  LIVE
  0001369568
  CATALYST PHARMACEUTICALS, INC.
  001-33057
  355 ALHAMBRA CIRCLE
  SUITE 801
  CORAL GABLES
  FL
  33134
  (305) 529-2522
  MCENANY PATRICK J
  Director
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  44655
  971327.03
  119273436
  11/14/2024
  NASDAQ
  Common
  11/14/2024
  Option Granted - 05/29/2018
  Issuer
  N
  44655
  11/14/2024
  Cash
  N
  Patrick Mcenany
  355 Alhambra Circle Suite 801
  Coral Gables
  FL
  33134
  Common
  11/11/2024
  230000
  5416008.48
  Patrick Mcenany
  355 Alhambra Circle Suite 801
  Coral Gables
  FL
  33134
  Common
  11/12/2024
  262000
  6094084.20
  Patrick Mcenany
  355 Alhambra Circle Suite 801
  Coral Gables
  FL
  33134
  Common
  11/13/2024
  92500
  2125996.50
  11/14/2024
  /s/ Tyler Johnson, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Patrick Mcenany