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        <filer>
          <filerCredentials>
            <cik>0001913265</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
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      <issuerInfo>
        <issuerCik>0001878313</issuerCik>
        <issuerName>MAIA Biotechnology, Inc.</issuerName>
        <secFileNumber>001-41455</secFileNumber>
        <issuerAddress>
          <com:street1>444 WEST LAKE STREET, SUITE 1700</com:street1>
          <com:city>CHICAGO</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60606</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>312-416-8592</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Obrocea Mihail</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>26100</noOfUnitsSold>
        <aggregateMarketValue>33408.00</aggregateMarketValue>
        <noOfUnitsOutstanding>14213511</noOfUnitsOutstanding>
        <approxSaleDate>01/19/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/16/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Private Investment Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>26100</amountOfSecuritiesAcquired>
        <paymentDate>09/30/2021</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>01/19/2024</noticeDate>
        <signature>/s/ Cristina Garcia, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Obrocea Mihail</signature>
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text: 144
  0001913265
  XXXXXXXX
  LIVE
  0001878313
  MAIA Biotechnology, Inc.
  001-41455
  444 WEST LAKE STREET, SUITE 1700
  CHICAGO
  IL
  60606
  312-416-8592
  Obrocea Mihail
  Former director
  Common
  Fidelity Brokerage Services LLC
  245 Summer Street
  Boston
  MA
  02110
  26100
  33408.00
  14213511
  01/19/2024
  NYSE
  Common
  06/16/2021
  Private Investment Purchase
  Issuer
  N
  26100
  09/30/2021
  Cash
  Y
  01/19/2024
  /s/ Cristina Garcia, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Obrocea Mihail