content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001277476</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001314102</issuerCik>
        <issuerName>EyePoint Pharmaceuticals, Inc.</issuerName>
        <secFileNumber>000-51122</secFileNumber>
        <issuerAddress>
          <com:street1>480 Pleasant Street</com:street1>
          <com:city>Watertown</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02472</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-926-5000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>David R. Guyer</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>36975</noOfUnitsSold>
        <aggregateMarketValue>329817</aggregateMarketValue>
        <noOfUnitsOutstanding>53518210</noOfUnitsOutstanding>
        <approxSaleDate>10/14/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>02/09/2023</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1850</amountOfSecuritiesAcquired>
        <paymentDate>02/09/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>10/14/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>35125</amountOfSecuritiesAcquired>
        <paymentDate>10/14/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Some of the shares covered by this filing are stock options that will be exercised within 3 months from the date of this filing.  Sales that were executed on October 14, 2024 are being reported on this Form 144 filed today given the EDGAR system was not accepting filings on October 14, 2024 in observance of the federal holiday.</remarks>
      <noticeSignature>
        <noticeDate>10/15/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>01/25/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for David R. Guyer</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3868}]
text: 144
  0001277476
  XXXXXXXX
  LIVE
  0001314102
  EyePoint Pharmaceuticals, Inc.
  000-51122
  480 Pleasant Street
  Watertown
  MA
  02472
  617-926-5000
  David R. Guyer
  Former Director
  Common Stock
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  36975
  329817
  53518210
  10/14/2024
  NASDAQ
  Common Stock
  02/09/2023
  RSU Vesting
  Issuer
  N
  1850
  02/09/2023
  Compensation
  Common Stock
  10/14/2024
  Stock Option Exercise
  Issuer
  N
  35125
  10/14/2024
  Cash
  Y
  Some of the shares covered by this filing are stock options that will be exercised within 3 months from the date of this filing.  Sales that were executed on October 14, 2024 are being reported on this Form 144 filed today given the EDGAR system was not accepting filings on October 14, 2024 in observance of the federal holiday.
  10/15/2024
  01/25/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for David R. Guyer