content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001787630</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000354950</issuerCik>
        <issuerName>HOME DEPOT, INC.</issuerName>
        <secFileNumber>001-08207</secFileNumber>
        <issuerAddress>
          <com:street1>2455 PACES FERRY ROAD</com:street1>
          <com:city>ATLANTA</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30339-4024</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>770-433-8211</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>McPhail Richard V</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>MERRILL LYNCH</name>
          <address>
            <com:street1>3455 PEACTHREE RD NE</com:street1>
            <com:street2>SUITE 1000</com:street2>
            <com:city>ATLANTA</com:city>
            <com:stateOrCountry>GA</com:stateOrCountry>
            <com:zipCode>30326</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>2000</noOfUnitsSold>
        <aggregateMarketValue>664520.00</aggregateMarketValue>
        <noOfUnitsOutstanding>1000065982</noOfUnitsOutstanding>
        <approxSaleDate>09/01/2023</approxSaleDate>
        <securitiesExchangeName>NEW YORK</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <acquiredDate>09/01/2023</acquiredDate>
        <natureOfAcquisitionTransaction>EXERCISE OF A STOCK AWARD</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>HOME DEPOT, INC.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2000</amountOfSecuritiesAcquired>
        <paymentDate>09/01/2023</paymentDate>
        <natureOfPayment>COMPENSATORY PAYMENT</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>09/01/2023</noticeDate>
        <signature>RICHARD MCPHAIL</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2777}]
text: 144
  0001787630
  XXXXXXXX
  LIVE
  0000354950
  HOME DEPOT, INC.
  001-08207
  2455 PACES FERRY ROAD
  ATLANTA
  GA
  30339-4024
  770-433-8211
  McPhail Richard V
  Officer
  COMMON
  MERRILL LYNCH
  3455 PEACTHREE RD NE
  SUITE 1000
  ATLANTA
  GA
  30326
  2000
  664520.00
  1000065982
  09/01/2023
  NEW YORK
  COMMON
  09/01/2023
  EXERCISE OF A STOCK AWARD
  HOME DEPOT, INC.
  N
  2000
  09/01/2023
  COMPENSATORY PAYMENT
  Y
  09/01/2023
  RICHARD MCPHAIL