content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001814304</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001492422</issuerCik>
        <issuerName>Apellis Pharmaceuticals, Inc.</issuerName>
        <secFileNumber>001-38276</secFileNumber>
        <issuerAddress>
          <com:street1>100 FIFTH AVENUE</com:street1>
          <com:city>WALTHAM</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-977-5700</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Lewis Karen</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1738</noOfUnitsSold>
        <aggregateMarketValue>112963.04</aggregateMarketValue>
        <noOfUnitsOutstanding>118499945</noOfUnitsOutstanding>
        <approxSaleDate>01/22/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/19/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1738</amountOfSecuritiesAcquired>
        <paymentDate>01/19/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Karen L. Lewis</name>
          <address>
            <com:street1>100 Fifth Avenue</com:street1>
            <com:city>Waltham</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02451</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/16/2024</saleDate>
        <amountOfSecuritiesSold>1632</amountOfSecuritiesSold>
        <grossProceeds>109031.64</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Karen L. Lewis</name>
          <address>
            <com:street1>100 Fifth Avenue</com:street1>
            <com:city>Waltham</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02451</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/17/2024</saleDate>
        <amountOfSecuritiesSold>3276</amountOfSecuritiesSold>
        <grossProceeds>214840.08</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>01/22/2024</noticeDate>
        <signature>/s/ Jodi Disselkamp, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Karen L. Lewis</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3997}]
text: 144
  0001814304
  XXXXXXXX
  LIVE
  0001492422
  Apellis Pharmaceuticals, Inc.
  001-38276
  100 FIFTH AVENUE
  WALTHAM
  MA
  02451
  617-977-5700
  Lewis Karen
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  1738
  112963.04
  118499945
  01/22/2024
  NASDAQ
  Common
  01/19/2024
  Restricted Stock Vesting
  Issuer
  N
  1738
  01/19/2024
  Compensation
  N
  Karen L. Lewis
  100 Fifth Avenue
  Waltham
  MA
  02451
  Common
  01/16/2024
  1632
  109031.64
  Karen L. Lewis
  100 Fifth Avenue
  Waltham
  MA
  02451
  Common
  01/17/2024
  3276
  214840.08
  01/22/2024
  /s/ Jodi Disselkamp, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Karen L. Lewis