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        <filer>
          <filerCredentials>
            <cik>0001786720</cik>
            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001770787</issuerCik>
        <issuerName>10X Genomics Inc</issuerName>
        <secFileNumber>001-39035</secFileNumber>
        <issuerAddress>
          <com:street1>6230 Stoneridge Mall Road</com:street1>
          <com:city>Pleasanton</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94588</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>925-401-7300</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Serge Saxonov</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>6000</noOfUnitsSold>
        <aggregateMarketValue>296940</aggregateMarketValue>
        <noOfUnitsOutstanding>103361382</noOfUnitsOutstanding>
        <approxSaleDate>09/14/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <acquiredDate>08/02/2019</acquiredDate>
        <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4000</amountOfSecuritiesAcquired>
        <paymentDate>08/02/2019</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <acquiredDate>08/22/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RSU award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2000</amountOfSecuritiesAcquired>
        <paymentDate>08/22/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Serge Saxonov</name>
          <address>
            <com:street1>Care of 10X Genomics Inc</com:street1>
            <com:street2>6230 Stoneridge Mall Road</com:street2>
            <com:city>Pleasanton</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94588</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>07/14/2023</saleDate>
        <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
        <grossProceeds>116090</grossProceeds>
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      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Serge Saxonov</name>
          <address>
            <com:street1>Care of 10X Genomics Inc</com:street1>
            <com:street2>6230 Stoneridge Mall Road</com:street2>
            <com:city>Pleasanton</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94588</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>07/19/2023</saleDate>
        <amountOfSecuritiesSold>40000</amountOfSecuritiesSold>
        <grossProceeds>2401088</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Serge Saxonov</name>
          <address>
            <com:street1>Care of 10X Genomics Inc</com:street1>
            <com:street2>6230 Stoneridge Mall Road</com:street2>
            <com:city>Pleasanton</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94588</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>08/14/2023</saleDate>
        <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
        <grossProceeds>100212</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>09/14/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>12/13/2022</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Serge Saxonov</signature>
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text: 144
  0001786720
  XXXXXXXX
  LIVE
  0001770787
  10X Genomics Inc
  001-39035
  6230 Stoneridge Mall Road
  Pleasanton
  CA
  94588
  925-401-7300
  Serge Saxonov
  Affiliate
  Class A Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  6000
  296940
  103361382
  09/14/2023
  Nasdaq
  Class A Common
  08/02/2019
  Option Exercise
  Issuer
  N
  4000
  08/02/2019
  Cash
  Class A Common
  08/22/2022
  RSU award
  Issuer
  N
  2000
  08/22/2022
  Cash
  N
  Serge Saxonov
  Care of 10X Genomics Inc
  6230 Stoneridge Mall Road
  Pleasanton
  CA
  94588
  Class A Common
  07/14/2023
  2000
  116090
  Serge Saxonov
  Care of 10X Genomics Inc
  6230 Stoneridge Mall Road
  Pleasanton
  CA
  94588
  Class A Common
  07/19/2023
  40000
  2401088
  Serge Saxonov
  Care of 10X Genomics Inc
  6230 Stoneridge Mall Road
  Pleasanton
  CA
  94588
  Class A Common
  08/14/2023
  2000
  100212
  09/14/2023
  12/13/2022
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Serge Saxonov