content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001427470</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001350653</issuerCik>
        <issuerName>Alphatec Holdings, Inc.</issuerName>
        <secFileNumber>000-52024</secFileNumber>
        <issuerAddress>
          <com:street1>1950 Camino Vida Roble</com:street1>
          <com:city>Carlsbad</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92008</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>760-431-9286</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Paul Segal</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>10% shareholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>JP Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>338825</noOfUnitsSold>
        <aggregateMarketValue>5224682</aggregateMarketValue>
        <noOfUnitsOutstanding>118496526</noOfUnitsOutstanding>
        <approxSaleDate>05/10/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>11/23/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Open market purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>See nature of acquisition</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>67496</amountOfSecuritiesAcquired>
        <paymentDate>11/26/2021</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>11/24/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Open market purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>See nature of acquisition</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>100000</amountOfSecuritiesAcquired>
        <paymentDate>11/29/2021</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/09/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Open market purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>See nature of acquisition</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>71129</amountOfSecuritiesAcquired>
        <paymentDate>06/13/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/10/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Open market purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>See nature of acquisition</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>200</amountOfSecuritiesAcquired>
        <paymentDate>06/14/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/14/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Open market purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>See nature of acquisition</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
        <paymentDate>06/16/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Open market purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>See nature of acquisition</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
        <paymentDate>06/17/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/10/2023</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Paul Segal</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5598}]
text: 144
  0001427470
  XXXXXXXX
  LIVE
  0001350653
  Alphatec Holdings, Inc.
  000-52024
  1950 Camino Vida Roble
  Carlsbad
  CA
  92008
  760-431-9286
  Paul Segal
  10% shareholder
  Common
  JP Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  338825
  5224682
  118496526
  05/10/2023
  NASDAQ
  Common
  11/23/2021
  Open market purchase
  See nature of acquisition
  N
  67496
  11/26/2021
  Cash
  Common
  11/24/2021
  Open market purchase
  See nature of acquisition
  N
  100000
  11/29/2021
  Cash
  Common
  06/09/2022
  Open market purchase
  See nature of acquisition
  N
  71129
  06/13/2022
  Cash
  Common
  06/10/2022
  Open market purchase
  See nature of acquisition
  N
  200
  06/14/2022
  Cash
  Common
  06/14/2022
  Open market purchase
  See nature of acquisition
  N
  50000
  06/16/2022
  Cash
  Common
  06/15/2022
  Open market purchase
  See nature of acquisition
  N
  50000
  06/17/2022
  Cash
  Y
  05/10/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Paul Segal