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        <issuerAddress>
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          <com:city>MADISON</com:city>
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          <com:zipCode>53719</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>608-284-5700</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Condella Sarah</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
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        </relationshipsToIssuer>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
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        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
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        <paymentDate>01/16/2019</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
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        <isGiftTransaction>N</isGiftTransaction>
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        <paymentDate>02/29/2020</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
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        <isGiftTransaction>N</isGiftTransaction>
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        <paymentDate>02/27/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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          <name>Sarah K. Condella</name>
          <address>
            <com:street1>5505 Endeavor Lane</com:street1>
            <com:city>Madison</com:city>
            <com:stateOrCountry>WI</com:stateOrCountry>
            <com:zipCode>53719</com:zipCode>
          </address>
        </sellerDetails>
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        <sellerDetails>
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            <com:zipCode>53719</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/15/2024</saleDate>
        <amountOfSecuritiesSold>965</amountOfSecuritiesSold>
        <grossProceeds>59279.76</grossProceeds>
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        <sellerDetails>
          <name>Sarah K. Condella</name>
          <address>
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            <com:stateOrCountry>WI</com:stateOrCountry>
            <com:zipCode>53719</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/21/2024</saleDate>
        <amountOfSecuritiesSold>1079</amountOfSecuritiesSold>
        <grossProceeds>66360.77</grossProceeds>
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            <com:zipCode>53719</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/22/2024</saleDate>
        <amountOfSecuritiesSold>1013</amountOfSecuritiesSold>
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        <sellerDetails>
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            <com:zipCode>53719</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/23/2024</saleDate>
        <amountOfSecuritiesSold>1021</amountOfSecuritiesSold>
        <grossProceeds>60974.12</grossProceeds>
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      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Sarah K. Condella</name>
          <address>
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            <com:stateOrCountry>WI</com:stateOrCountry>
            <com:zipCode>53719</com:zipCode>
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        <securitiesClassTitle>Common</securitiesClassTitle>
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      <securitiesSoldInPast3Months>
        <sellerDetails>
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      <noticeSignature>
        <noticeDate>04/01/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>05/18/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/S/ Adam Gehring, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Sarah K. Condella</signature>
      </noticeSignature>
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text: 144
  0001839989
  XXXXXXXX
  LIVE
  0001124140
  EXACT SCIENCES CORP
  001-35092
  5505 ENDEAVOR LANE
  MADISON
  WI
  53719
  608-284-5700
  Condella Sarah
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  2000
  140000.00
  181530967
  04/01/2024
  NASDAQ
  Common
  01/16/2019
  Restricted Stock Vesting
  Issuer
  N
  563
  01/16/2019
  Compensation
  Common
  02/29/2020
  Restricted Stock Vesting
  Issuer
  N
  1435
  02/29/2020
  Compensation
  Common
  02/27/2022
  Restricted Stock Vesting
  Issuer
  N
  2
  02/27/2022
  Compensation
  N
  Sarah K. Condella
  5505 Endeavor Lane
  Madison
  WI
  53719
  Common
  01/02/2024
  2000
  147000.00
  Sarah K. Condella
  5505 Endeavor Lane
  Madison
  WI
  53719
  Common
  02/15/2024
  965
  59279.76
  Sarah K. Condella
  5505 Endeavor Lane
  Madison
  WI
  53719
  Common
  02/21/2024
  1079
  66360.77
  Sarah K. Condella
  5505 Endeavor Lane
  Madison
  WI
  53719
  Common
  02/22/2024
  1013
  60551.97
  Sarah K. Condella
  5505 Endeavor Lane
  Madison
  WI
  53719
  Common
  02/23/2024
  1021
  60974.12
  Sarah K. Condella
  5505 Endeavor Lane
  Madison
  WI
  53719
  Common
  02/27/2024
  1880
  106959.97
  Sarah K. Condella
  5505 Endeavor Lane
  Madison
  WI
  53719
  Common
  03/01/2024
  1724
  102266.13
  Sarah K. Condella
  5505 Endeavor Lane
  Madison
  WI
  53719
  Common
  03/28/2024
  2000
  140000.00
  04/01/2024
  05/18/2023
  /S/ Adam Gehring, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Sarah K. Condella