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        <issuerName>Ginkgo Bioworks Holdings, Inc.</issuerName>
        <secFileNumber>001-40097</secFileNumber>
        <issuerAddress>
          <com:street1>27 DRYDOCK AVENUE</com:street1>
          <com:street2>8TH FLOOR</com:street2>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(877) 442-5362</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>DEKKERS MARIJN E</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
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        <securitiesClassTitle>Class A</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem St</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1727056</noOfUnitsSold>
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        <securitiesExchangeName>NYSE</securitiesExchangeName>
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        <amountOfSecuritiesAcquired>80883</amountOfSecuritiesAcquired>
        <paymentDate>11/19/2021</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>12/01/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2572</amountOfSecuritiesAcquired>
        <paymentDate>12/01/2021</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>01/01/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
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        <amountOfSecuritiesAcquired>2572</amountOfSecuritiesAcquired>
        <paymentDate>01/01/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>02/01/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2572</amountOfSecuritiesAcquired>
        <paymentDate>02/01/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>03/01/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
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        <amountOfSecuritiesAcquired>2572</amountOfSecuritiesAcquired>
        <paymentDate>03/01/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>03/11/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1390938</amountOfSecuritiesAcquired>
        <paymentDate>03/11/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>04/01/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2572</amountOfSecuritiesAcquired>
        <paymentDate>04/01/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>11/01/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>171454</amountOfSecuritiesAcquired>
        <paymentDate>11/01/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>06/10/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>70921</amountOfSecuritiesAcquired>
        <paymentDate>06/10/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Marinus E. Dekkers and Marijn E. Dekkers are one and the same person.</remarks>
      <noticeSignature>
        <noticeDate>05/14/2024</noticeDate>
        <signature>/s/ Eric Janiak, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Marinus E. Dekkers</signature>
      </noticeSignature>
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text: 144
  0001216068
  XXXXXXXX
  LIVE
  0001830214
  Ginkgo Bioworks Holdings, Inc.
  001-40097
  27 DRYDOCK AVENUE
  8TH FLOOR
  BOSTON
  MA
  02210
  (877) 442-5362
  DEKKERS MARIJN E
  Director
  Class A
  Fidelity Brokerage Services LLC
  900 Salem St
  Smithfield
  RI
  02917
  1727056
  1605120.56
  1709063953
  05/14/2024
  NYSE
  Class A
  11/19/2021
  Restricted Stock Vesting
  Issuer
  N
  80883
  11/19/2021
  Compensation
  Class A
  12/01/2021
  Restricted Stock Vesting
  Issuer
  N
  2572
  12/01/2021
  Compensation
  Class A
  01/01/2022
  Restricted Stock Vesting
  Issuer
  N
  2572
  01/01/2022
  Compensation
  Class A
  02/01/2022
  Restricted Stock Vesting
  Issuer
  N
  2572
  02/01/2022
  Compensation
  Class A
  03/01/2022
  Restricted Stock Vesting
  Issuer
  N
  2572
  03/01/2022
  Compensation
  Class A
  03/11/2022
  Restricted Stock Vesting
  Issuer
  N
  1390938
  03/11/2022
  Compensation
  Class A
  04/01/2022
  Restricted Stock Vesting
  Issuer
  N
  2572
  04/01/2022
  Compensation
  Class A
  11/01/2022
  Restricted Stock Vesting
  Issuer
  N
  171454
  11/01/2022
  Compensation
  Class A
  06/10/2023
  Restricted Stock Vesting
  Issuer
  N
  70921
  06/10/2023
  Compensation
  Y
  Marinus E. Dekkers and Marijn E. Dekkers are one and the same person.
  05/14/2024
  /s/ Eric Janiak, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Marinus E. Dekkers