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            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001492691</issuerCik>
        <issuerName>Knight-Swift Transportation Holdings Inc.</issuerName>
        <secFileNumber>001-35007</secFileNumber>
        <issuerAddress>
          <com:street1>2200 SOUTH 75TH AVENUE</com:street1>
          <com:city>PHOENIX</com:city>
          <com:stateOrCountry>AZ</com:stateOrCountry>
          <com:zipCode>85043</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>602-269-9700</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KNIGHT KEVIN P</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Merrill Lynch</name>
          <address>
            <com:street1>3455 Peachtree Rd NE</com:street1>
            <com:street2>Ste 1000</com:street2>
            <com:city>Atlanta</com:city>
            <com:stateOrCountry>GA</com:stateOrCountry>
            <com:zipCode>30326</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>64139</noOfUnitsSold>
        <aggregateMarketValue>3629648.50</aggregateMarketValue>
        <noOfUnitsOutstanding>161030000</noOfUnitsOutstanding>
        <approxSaleDate>05/09/2023</approxSaleDate>
        <securitiesExchangeName>New York</securitiesExchangeName>
      </securitiesInformation>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/31/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Vesting of a Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Knight-Swift Transportation Holdings Inc.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1280</amountOfSecuritiesAcquired>
        <paymentDate>05/31/2022</paymentDate>
        <natureOfPayment>Compensatory Payment</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/31/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Vesting of a Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Knight-Swift Transportation Holdings Inc.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>62859</amountOfSecuritiesAcquired>
        <paymentDate>01/31/2023</paymentDate>
        <natureOfPayment>Compensatory Payment</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/09/2023</noticeDate>
        <signature>Kevin P Knight</signature>
      </noticeSignature>
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text: 144
  0001187342
  XXXXXXXX
  LIVE
  0001492691
  Knight-Swift Transportation Holdings Inc.
  001-35007
  2200 SOUTH 75TH AVENUE
  PHOENIX
  AZ
  85043
  602-269-9700
  KNIGHT KEVIN P
  Officer
  Director
  Common
  Merrill Lynch
  3455 Peachtree Rd NE
  Ste 1000
  Atlanta
  GA
  30326
  64139
  3629648.50
  161030000
  05/09/2023
  New York
  Common
  05/31/2022
  Vesting of a Stock Award
  Knight-Swift Transportation Holdings Inc.
  N
  1280
  05/31/2022
  Compensatory Payment
  Common
  01/31/2023
  Vesting of a Stock Award
  Knight-Swift Transportation Holdings Inc.
  N
  62859
  01/31/2023
  Compensatory Payment
  Y
  05/09/2023
  Kevin P Knight