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      <submissionType>144</submissionType>
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        <filer>
          <filerCredentials>
            <cik>0001638474</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
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      <issuerInfo>
        <issuerCik>0001597264</issuerCik>
        <issuerName>Blueprint Medicines Corp</issuerName>
        <secFileNumber>001-37359</secFileNumber>
        <issuerAddress>
          <com:street1>45 SIDNEY STREET</com:street1>
          <com:city>CAMBRIDGE</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-374-7580</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Albers Jeffrey W.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Citigroup Global Markets Inc</name>
          <address>
            <com:street1>388 Greenwich Street</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10013</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>5000</noOfUnitsSold>
        <aggregateMarketValue>505686.50</aggregateMarketValue>
        <noOfUnitsOutstanding>64582163</noOfUnitsOutstanding>
        <approxSaleDate>05/27/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>common</securitiesClassTitle>
        <acquiredDate>02/16/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Grant of vested options</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
        <paymentDate>02/16/2021</paymentDate>
        <natureOfPayment>Compensation for services rendered</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/27/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>05/08/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Jeffrey W. Albers</signature>
      </noticeSignature>
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text: 144
  0001638474
  XXXXXXXX
  LIVE
  0001597264
  Blueprint Medicines Corp
  001-37359
  45 SIDNEY STREET
  CAMBRIDGE
  MA
  02139
  617-374-7580
  Albers Jeffrey W.
  Director
  common
  Citigroup Global Markets Inc
  388 Greenwich Street
  New York
  NY
  10013
  5000
  505686.50
  64582163
  05/27/2025
  NASDAQ
  common
  02/16/2017
  Grant of vested options
  Issuer
  N
  5000
  02/16/2021
  Compensation for services rendered
  Y
  05/27/2025
  05/08/2024
  /s/ Jeffrey W. Albers