content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001818525</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001528115</issuerCik>
        <issuerName>Annexon, Inc.</issuerName>
        <secFileNumber>001-39402</secFileNumber>
        <issuerAddress>
          <com:street1>1400 SIERRA POINT PARKWAY</com:street1>
          <com:street2>BLDG C, SUITE 200</com:street2>
          <com:city>BRISBANE</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94005</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(650)-822-5500</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Yednock Ted</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>5408</noOfUnitsSold>
        <aggregateMarketValue>40073.28</aggregateMarketValue>
        <noOfUnitsOutstanding>105653962</noOfUnitsOutstanding>
        <approxSaleDate>10/15/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/15/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Options Granted - 08/11/2016</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>5408</amountOfSecuritiesAcquired>
        <paymentDate>10/15/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ted Yednock</name>
          <address>
            <com:street1>1400 Sierra Point Parkway, Bldg C</com:street1>
            <com:street2>Suite 200</com:street2>
            <com:city>Brisbane</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94005</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>07/15/2024</saleDate>
        <amountOfSecuritiesSold>1106</amountOfSecuritiesSold>
        <grossProceeds>6655.58</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ted Yednock</name>
          <address>
            <com:street1>1400 Sierra Point Parkway, Bldg C</com:street1>
            <com:street2>Suite 200</com:street2>
            <com:city>Brisbane</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94005</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>08/29/2024</saleDate>
        <amountOfSecuritiesSold>5500</amountOfSecuritiesSold>
        <grossProceeds>32725.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ted Yednock</name>
          <address>
            <com:street1>1400 Sierra Point Parkway, Bldg C</com:street1>
            <com:street2>Suite 200</com:street2>
            <com:city>Brisbane</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94005</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/05/2024</saleDate>
        <amountOfSecuritiesSold>5500</amountOfSecuritiesSold>
        <grossProceeds>31020.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ted Yednock</name>
          <address>
            <com:street1>1400 Sierra Point Parkway, Bldg C</com:street1>
            <com:street2>Suite 200</com:street2>
            <com:city>Brisbane</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94005</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/12/2024</saleDate>
        <amountOfSecuritiesSold>5500</amountOfSecuritiesSold>
        <grossProceeds>33880.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ted Yednock</name>
          <address>
            <com:street1>1400 Sierra Point Parkway, Bldg C</com:street1>
            <com:street2>Suite 200</com:street2>
            <com:city>Brisbane</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94005</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/19/2024</saleDate>
        <amountOfSecuritiesSold>4500</amountOfSecuritiesSold>
        <grossProceeds>31950.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>10/15/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>04/12/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Ted Yednock </signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6185}]
text: 144
  0001818525
  XXXXXXXX
  LIVE
  0001528115
  Annexon, Inc.
  001-39402
  1400 SIERRA POINT PARKWAY
  BLDG C, SUITE 200
  BRISBANE
  CA
  94005
  (650)-822-5500
  Yednock Ted
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  5408
  40073.28
  105653962
  10/15/2024
  NASDAQ
  Common
  10/15/2024
  Options Granted - 08/11/2016
  Issuer
  N
  5408
  10/15/2024
  Cash
  N
  Ted Yednock
  1400 Sierra Point Parkway, Bldg C
  Suite 200
  Brisbane
  CA
  94005
  Common
  07/15/2024
  1106
  6655.58
  Ted Yednock
  1400 Sierra Point Parkway, Bldg C
  Suite 200
  Brisbane
  CA
  94005
  Common
  08/29/2024
  5500
  32725.00
  Ted Yednock
  1400 Sierra Point Parkway, Bldg C
  Suite 200
  Brisbane
  CA
  94005
  Common
  09/05/2024
  5500
  31020.00
  Ted Yednock
  1400 Sierra Point Parkway, Bldg C
  Suite 200
  Brisbane
  CA
  94005
  Common
  09/12/2024
  5500
  33880.00
  Ted Yednock
  1400 Sierra Point Parkway, Bldg C
  Suite 200
  Brisbane
  CA
  94005
  Common
  09/19/2024
  4500
  31950.00
  10/15/2024
  04/12/2024
  /s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Ted Yednock