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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001704241</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0000350698</issuerCik>
        <issuerName>AUTONATION, INC.</issuerName>
        <secFileNumber>001-13107</secFileNumber>
        <issuerAddress>
          <com:street1>200 SW 1ST AVE</com:street1>
          <com:street2>SUITE 1600</com:street2>
          <com:city>FORT LAUDERDALE</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33301</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>9547696000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>EDMUNDS C COLEMAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Merrill Lynch</name>
          <address>
            <com:street1>3455 Peachtree Road NE</com:street1>
            <com:street2>Suite 1000</com:street2>
            <com:city>Atlanta</com:city>
            <com:stateOrCountry>GA</com:stateOrCountry>
            <com:zipCode>30326</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>4500</noOfUnitsSold>
        <aggregateMarketValue>721569.26</aggregateMarketValue>
        <noOfUnitsOutstanding>44047628</noOfUnitsOutstanding>
        <approxSaleDate>08/11/2023</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/01/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Vesting of a Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>AUTONATION, INC.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>570</amountOfSecuritiesAcquired>
        <paymentDate>06/01/2017</paymentDate>
        <natureOfPayment>Compensatory Payment</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/01/2019</acquiredDate>
        <natureOfAcquisitionTransaction>Vesting of a Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>AUTONATION, INC.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>693</amountOfSecuritiesAcquired>
        <paymentDate>06/01/2019</paymentDate>
        <natureOfPayment>Compensatory Payment</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/01/2020</acquiredDate>
        <natureOfAcquisitionTransaction>Vesting of a Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>AUTONATION, INC.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3237</amountOfSecuritiesAcquired>
        <paymentDate>03/01/2020</paymentDate>
        <natureOfPayment>Compensatory Payment</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>08/11/2023</noticeDate>
        <signature>COLEMAN C EDMUNDS</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001704241
  XXXXXXXX
  LIVE
  0000350698
  AUTONATION, INC.
  001-13107
  200 SW 1ST AVE
  SUITE 1600
  FORT LAUDERDALE
  FL
  33301
  9547696000
  EDMUNDS C COLEMAN
  Officer
  Common
  Merrill Lynch
  3455 Peachtree Road NE
  Suite 1000
  Atlanta
  GA
  30326
  4500
  721569.26
  44047628
  08/11/2023
  NYSE
  Common
  06/01/2017
  Vesting of a Stock Award
  AUTONATION, INC.
  N
  570
  06/01/2017
  Compensatory Payment
  Common
  06/01/2019
  Vesting of a Stock Award
  AUTONATION, INC.
  N
  693
  06/01/2019
  Compensatory Payment
  Common
  03/01/2020
  Vesting of a Stock Award
  AUTONATION, INC.
  N
  3237
  03/01/2020
  Compensatory Payment
  Y
  08/11/2023
  COLEMAN C EDMUNDS