content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001970876</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001070081</issuerCik>
        <issuerName>PTC THERAPEUTICS, INC.</issuerName>
        <secFileNumber>001-35969</secFileNumber>
        <issuerAddress>
          <com:street1>100 CORPORATE COURT</com:street1>
          <com:city>SOUTH PLAINFIELD</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07080-2449</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>9082227000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Almstead Zheng Yang</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Member of immediate family of any of the foregoing</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>28</noOfUnitsSold>
        <aggregateMarketValue>763.02</aggregateMarketValue>
        <noOfUnitsOutstanding>75463145</noOfUnitsOutstanding>
        <approxSaleDate>01/30/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/29/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>28</amountOfSecuritiesAcquired>
        <paymentDate>01/29/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Zheng Y. Almstead</name>
          <address>
            <com:street1>100 Corporate Court</com:street1>
            <com:city>South Plainfield</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/08/2024</saleDate>
        <amountOfSecuritiesSold>53</amountOfSecuritiesSold>
        <grossProceeds>1517.94</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Neil G. Almstead</name>
          <address>
            <com:street1>100 Corporate Court</com:street1>
            <com:city>South Plainfield</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/08/2024</saleDate>
        <amountOfSecuritiesSold>1236</amountOfSecuritiesSold>
        <grossProceeds>35399.41</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Zheng Y. Almstead</name>
          <address>
            <com:street1>100 Corporate Court</com:street1>
            <com:city>South Plainfield</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/09/2024</saleDate>
        <amountOfSecuritiesSold>100</amountOfSecuritiesSold>
        <grossProceeds>2901.48</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Neil G. Almstead</name>
          <address>
            <com:street1>100 Corporate Court</com:street1>
            <com:city>South Plainfield</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/09/2024</saleDate>
        <amountOfSecuritiesSold>1521</amountOfSecuritiesSold>
        <grossProceeds>44131.51</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>For the Securities Sold During The Past 3 Months Section: In regards to sales from Neil G. Almstead on 01/08/2024 and 01/09/2024, Neil G. Almstead is the spouse of Zheng Y. Almstead.</remarks>
      <noticeSignature>
        <noticeDate>01/30/2024</noticeDate>
        <signature>/S/ Adam Gehring, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Zheng Y. Almstead</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001970876
  XXXXXXXX
  LIVE
  0001070081
  PTC THERAPEUTICS, INC.
  001-35969
  100 CORPORATE COURT
  SOUTH PLAINFIELD
  NJ
  07080-2449
  9082227000
  Almstead Zheng Yang
  Member of immediate family of any of the foregoing
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  28
  763.02
  75463145
  01/30/2024
  NASDAQ
  Common
  01/29/2024
  Restricted Stock Vesting
  Issuer
  N
  28
  01/29/2024
  Compensation
  N
  Zheng Y. Almstead
  100 Corporate Court
  South Plainfield
  NJ
  07080
  Common
  01/08/2024
  53
  1517.94
  Neil G. Almstead
  100 Corporate Court
  South Plainfield
  NJ
  07080
  Common
  01/08/2024
  1236
  35399.41
  Zheng Y. Almstead
  100 Corporate Court
  South Plainfield
  NJ
  07080
  Common
  01/09/2024
  100
  2901.48
  Neil G. Almstead
  100 Corporate Court
  South Plainfield
  NJ
  07080
  Common
  01/09/2024
  1521
  44131.51
  For the Securities Sold During The Past 3 Months Section: In regards to sales from Neil G. Almstead on 01/08/2024 and 01/09/2024, Neil G. Almstead is the spouse of Zheng Y. Almstead.
  01/30/2024
  /S/ Adam Gehring, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Zheng Y. Almstead