content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0002020340</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001534969</issuerCik>
        <issuerName>SERA PROGNOSTICS, INC.</issuerName>
        <secFileNumber>001-40606</secFileNumber>
        <issuerAddress>
          <com:street1>2749 E. PARLEYS WAY</com:street1>
          <com:street2>SUITE 200</com:street2>
          <com:city>SALT LAKE CITY</com:city>
          <com:stateOrCountry>UT</com:stateOrCountry>
          <com:zipCode>84109</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(801) 990-0520</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CHV Investments, LLC (Pool 4)</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Shareholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Merrill Lynch, Pierce, Fenner &amp; Smith Incorporated</name>
          <address>
            <com:street1>555 California Street</com:street1>
            <com:street2>18th Floor</com:street2>
            <com:city>San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94104</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>8562</noOfUnitsSold>
        <aggregateMarketValue>71235.84</aggregateMarketValue>
        <noOfUnitsOutstanding>32804741</noOfUnitsOutstanding>
        <approxSaleDate>01/10/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>07/19/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Private Placement</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>8562</amountOfSecuritiesAcquired>
        <paymentDate>07/19/2021</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>01/10/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>06/10/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>Darshana Zaveri</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2965}]
text: 144
  0002020340
  XXXXXXXX
  LIVE
  0001534969
  SERA PROGNOSTICS, INC.
  001-40606
  2749 E. PARLEYS WAY
  SUITE 200
  SALT LAKE CITY
  UT
  84109
  (801) 990-0520
  CHV Investments, LLC (Pool 4)
  Shareholder
  Class A
  Merrill Lynch, Pierce, Fenner & Smith Incorporated
  555 California Street
  18th Floor
  San Francisco
  CA
  94104
  8562
  71235.84
  32804741
  01/10/2025
  NASDAQ
  Class A
  07/19/2021
  Private Placement
  Issuer
  N
  8562
  07/19/2021
  Cash
  Y
  01/10/2025
  06/10/2024
  Darshana Zaveri