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        <issuerAddress>
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          <com:stateOrCountry>CA</com:stateOrCountry>
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        <issuerContactPhone>800-719-0671</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Green Paula</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
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        <securitiesClassTitle>Common</securitiesClassTitle>
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          <address>
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            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
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        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
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        <paymentDate>12/05/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
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          <address>
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            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
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            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
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        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
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        <grossProceeds>13941.42</grossProceeds>
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            <com:zipCode>94080</com:zipCode>
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        <grossProceeds>143027.08</grossProceeds>
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        <sellerDetails>
          <name>Paula Green</name>
          <address>
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            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
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        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>11/04/2024</saleDate>
        <amountOfSecuritiesSold>1057</amountOfSecuritiesSold>
        <grossProceeds>43933.25</grossProceeds>
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      <securitiesSoldInPast3Months>
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          <name>Paula Green</name>
          <address>
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            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
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      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>12/06/2024</noticeDate>
        <signature>/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Paula Green</signature>
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text: 144
  0001753672
  XXXXXXXX
  LIVE
  0001581280
  Twist Bioscience Corp
  001-38720
  681 GATEWAY BLVD.
  SOUTH SAN FRANCISCO
  CA
  94080
  800-719-0671
  Green Paula
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  860
  45325.70
  59356440
  12/06/2024
  NASDAQ
  Common
  12/05/2024
  Restricted Stock Vesting
  Issuer
  N
  860
  12/05/2024
  Compensation
  N
  Paula Green
  681 Gateway Blvd
  South San Francisco
  CA
  94080
  Common
  09/06/2024
  912
  35714.65
  Paula Green
  681 Gateway Blvd
  South San Francisco
  CA
  94080
  Common
  09/20/2024
  297
  13941.42
  Paula Green
  681 Gateway Blvd
  South San Francisco
  CA
  94080
  Common
  10/02/2024
  3310
  143027.08
  Paula Green
  681 Gateway Blvd
  South San Francisco
  CA
  94080
  Common
  11/04/2024
  1057
  43933.25
  Paula Green
  681 Gateway Blvd
  South San Francisco
  CA
  94080
  Common
  11/06/2024
  5519
  246173.89
  Paula Green
  681 Gateway Blvd
  South San Francisco
  CA
  94080
  Common
  11/11/2024
  1347
  64652.63
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  12/06/2024
  /s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Paula Green