content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001738140</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000090498</issuerCik>
        <issuerName>SIMMONS FIRST NATIONAL CORP</issuerName>
        <secFileNumber>000-06253</secFileNumber>
        <issuerAddress>
          <com:street1>501 MAIN STREET</com:street1>
          <com:city>PINE BLUFF</com:city>
          <com:stateOrCountry>AR</com:stateOrCountry>
          <com:zipCode>71601</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>8705411000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Bass Dean O.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Cambridge Investment Research Inc</name>
          <address>
            <com:street1>1776 Pleasant Plain Rd</com:street1>
            <com:city>Fairfield</com:city>
            <com:stateOrCountry>IA</com:stateOrCountry>
            <com:zipCode>52556</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>50000</noOfUnitsSold>
        <aggregateMarketValue>1000000.00</aggregateMarketValue>
        <noOfUnitsOutstanding>126200000</noOfUnitsOutstanding>
        <approxSaleDate>08/01/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/26/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Merger/Acquisition</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>160860</amountOfSecuritiesAcquired>
        <paymentDate>04/25/2022</paymentDate>
        <natureOfPayment>cash/check</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>08/01/2023</noticeDate>
        <signature>/s/ Carmen Zamores as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Bass Dean O.</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001738140
  XXXXXXXX
  LIVE
  0000090498
  SIMMONS FIRST NATIONAL CORP
  000-06253
  501 MAIN STREET
  PINE BLUFF
  AR
  71601
  8705411000
  Bass Dean O.
  Director
  Common
  Cambridge Investment Research Inc
  1776 Pleasant Plain Rd
  Fairfield
  IA
  52556
  50000
  1000000.00
  126200000
  08/01/2023
  Nasdaq
  Common
  04/26/2022
  Merger/Acquisition
  Issuer
  N
  160860
  04/25/2022
  cash/check
  Y
  08/01/2023
  /s/ Carmen Zamores as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Bass Dean O.