content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001957680</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001124140</issuerCik>
        <issuerName>EXACT SCIENCES CORP</issuerName>
        <secFileNumber>001-35092</secFileNumber>
        <issuerAddress>
          <com:street1>5505 ENDEAVOR LANE</com:street1>
          <com:city>MADISON</com:city>
          <com:stateOrCountry>WI</com:stateOrCountry>
          <com:zipCode>53719</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>608-284-5700</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Herriott James</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>291</noOfUnitsSold>
        <aggregateMarketValue>17394.50</aggregateMarketValue>
        <noOfUnitsOutstanding>181530967</noOfUnitsOutstanding>
        <approxSaleDate>02/22/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/21/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>291</amountOfSecuritiesAcquired>
        <paymentDate>02/21/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>James Herriott</name>
          <address>
            <com:street1>5505 Endeavor Lane</com:street1>
            <com:city>Madison</com:city>
            <com:stateOrCountry>WI</com:stateOrCountry>
            <com:zipCode>53719</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/15/2024</saleDate>
        <amountOfSecuritiesSold>421</amountOfSecuritiesSold>
        <grossProceeds>25861.95</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>James Herriott</name>
          <address>
            <com:street1>5505 Endeavor Lane</com:street1>
            <com:city>Madison</com:city>
            <com:stateOrCountry>WI</com:stateOrCountry>
            <com:zipCode>53719</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/21/2024</saleDate>
        <amountOfSecuritiesSold>415</amountOfSecuritiesSold>
        <grossProceeds>25523.37</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>02/22/2024</noticeDate>
        <signature>/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for James Herriott</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001957680
  XXXXXXXX
  LIVE
  0001124140
  EXACT SCIENCES CORP
  001-35092
  5505 ENDEAVOR LANE
  MADISON
  WI
  53719
  608-284-5700
  Herriott James
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  291
  17394.50
  181530967
  02/22/2024
  NASDAQ
  Common
  02/21/2024
  Restricted Stock Vesting
  Issuer
  N
  291
  02/21/2024
  Compensation
  N
  James Herriott
  5505 Endeavor Lane
  Madison
  WI
  53719
  Common
  02/15/2024
  421
  25861.95
  James Herriott
  5505 Endeavor Lane
  Madison
  WI
  53719
  Common
  02/21/2024
  415
  25523.37
  02/22/2024
  /s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for James Herriott