content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001610762</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000804328</issuerCik>
        <issuerName>QUALCOMM INC/DE</issuerName>
        <secFileNumber>000-19528</secFileNumber>
        <issuerAddress>
          <com:street1>5775 MOREHOUSE DR</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92121</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>8585871121</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ACE HEATHER S</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1600</noOfUnitsSold>
        <aggregateMarketValue>220384.00</aggregateMarketValue>
        <noOfUnitsOutstanding>1098000000</noOfUnitsOutstanding>
        <approxSaleDate>05/02/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/20/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Company Grant Via RSU</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1600</amountOfSecuritiesAcquired>
        <paymentDate>05/20/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Heather Ace c/o QUALCOMM </name>
          <address>
            <com:street1>5775 MOREHOUSE DR</com:street1>
            <com:city>SAN DIEGO</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>92121</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock	</securitiesClassTitle>
        <saleDate>03/12/2025</saleDate>
        <amountOfSecuritiesSold>1600</amountOfSecuritiesSold>
        <grossProceeds>246784.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>shares are being sold from Ace Family Trust</remarks>
      <noticeSignature>
        <noticeDate>05/02/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>12/11/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Heather Ace</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001610762
  XXXXXXXX
  LIVE
  0000804328
  QUALCOMM INC/DE
  000-19528
  5775 MOREHOUSE DR
  SAN DIEGO
  CA
  92121
  8585871121
  ACE HEATHER S
  Officer
  Common Stock
  Fidelity Brokerage Services LLC
  245 Summer Street
  Boston
  MA
  02110
  1600
  220384.00
  1098000000
  05/02/2025
  NASDAQ
  Common
  05/20/2021
  Company Grant Via RSU
  Issuer
  N
  1600
  05/20/2021
  N/A
  N
  Heather Ace c/o QUALCOMM
  5775 MOREHOUSE DR
  SAN DIEGO
  CA
  92121
  Common Stock
  03/12/2025
  1600
  246784.00
  shares are being sold from Ace Family Trust
  05/02/2025
  12/11/2024
  /s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Heather Ace