content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001245624</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001604821</issuerCik>
        <issuerName>Natera, Inc.</issuerName>
        <secFileNumber>001-37478</secFileNumber>
        <issuerAddress>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BUILDING A SUITE 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>650-249-9090</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>James Healy</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affilate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>644000</noOfUnitsSold>
        <aggregateMarketValue>37712640</aggregateMarketValue>
        <noOfUnitsOutstanding>120151688</noOfUnitsOutstanding>
        <approxSaleDate>12/13/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>11/20/2014</acquiredDate>
        <natureOfAcquisitionTransaction>Purchase of Series F</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>488222</amountOfSecuritiesAcquired>
        <paymentDate>11/20/2014</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/01/2015</acquiredDate>
        <natureOfAcquisitionTransaction>IPO Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>72697</amountOfSecuritiesAcquired>
        <paymentDate>07/01/2015</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/02/2015</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market Purchase</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>83082</amountOfSecuritiesAcquired>
        <paymentDate>07/02/2015</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The shares filed today will be sold by Sofinnova Management VIII, L.L.C, James Healy as Managing Member.</remarks>
      <noticeSignature>
        <noticeDate>12/13/2023</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for James Healy</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4042}]
text: 144
  0001245624
  XXXXXXXX
  LIVE
  0001604821
  Natera, Inc.
  001-37478
  13011 MCCALLEN PASS
  BUILDING A SUITE 100
  Austin
  TX
  78753
  650-249-9090
  James Healy
  Affilate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  644000
  37712640
  120151688
  12/13/2023
  NASDAQ
  Common
  11/20/2014
  Purchase of Series F
  Issuer
  N
  488222
  11/20/2014
  Cash
  Common
  07/01/2015
  IPO Purchase
  Issuer
  N
  72697
  07/01/2015
  Cash
  Common
  07/02/2015
  Open Market Purchase
  Open Market Purchase
  N
  83082
  07/02/2015
  Cash
  Y
  The shares filed today will be sold by Sofinnova Management VIII, L.L.C, James Healy as Managing Member.
  12/13/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for James Healy