content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001185465</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001068851</issuerCik>
        <issuerName>PROSPERITY BANCSHARES INC</issuerName>
        <secFileNumber>001-35388</secFileNumber>
        <issuerAddress>
          <com:street1>4295 SAN FELIPE</com:street1>
          <com:street2>N/A</com:street2>
          <com:city>HOUSTON</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77027</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>7136939300</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>TIMANUS H E JR</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>FIDELITY BROKERAGE SERVICES LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>BOSTON</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>4000</noOfUnitsSold>
        <aggregateMarketValue>332520.00</aggregateMarketValue>
        <noOfUnitsOutstanding>95264666</noOfUnitsOutstanding>
        <approxSaleDate>11/13/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/12/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>OPEN MARKET</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2000</amountOfSecuritiesAcquired>
        <paymentDate>05/12/2022</paymentDate>
        <natureOfPayment>Cash/Check</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/16/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2000</amountOfSecuritiesAcquired>
        <paymentDate>06/16/2022</paymentDate>
        <natureOfPayment>Cash/Check</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The Form 144 is filed for the total amount of 4000 PB shares owned by the shareholder.
  - FMT CO CUST SEPP IRA
  FBO HALL E TIMANUS JR - 2,000 shares of PB
  - FMT CO CUST IRA
  FBO HALL E TIMANUS JR - 2,000 shares of PB</remarks>
      <noticeSignature>
        <noticeDate>11/13/2024</noticeDate>
        <signature>/s/ Jordyn Davis as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for TIMANUS H E JR </signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3635}]
text: 144
  0001185465
  XXXXXXXX
  LIVE
  0001068851
  PROSPERITY BANCSHARES INC
  001-35388
  4295 SAN FELIPE
  N/A
  HOUSTON
  TX
  77027
  7136939300
  TIMANUS H E JR
  Officer
  Common
  FIDELITY BROKERAGE SERVICES LLC
  245 Summer Street
  BOSTON
  MA
  02110
  4000
  332520.00
  95264666
  11/13/2024
  NYSE
  Common
  05/12/2022
  Open Market Purchase
  OPEN MARKET
  N
  2000
  05/12/2022
  Cash/Check
  Common
  06/16/2022
  Open Market Purchase
  Open Market
  N
  2000
  06/16/2022
  Cash/Check
  Y
  The Form 144 is filed for the total amount of 4000 PB shares owned by the shareholder.
  - FMT CO CUST SEPP IRA
  FBO HALL E TIMANUS JR - 2,000 shares of PB
  - FMT CO CUST IRA
  FBO HALL E TIMANUS JR - 2,000 shares of PB
  11/13/2024
  /s/ Jordyn Davis as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for TIMANUS H E JR