content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0002006673</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000859737</issuerCik>
        <issuerName>HOLOGIC INC</issuerName>
        <secFileNumber>001-36214</secFileNumber>
        <issuerAddress>
          <com:street1>250 CAMPUS DRIVE</com:street1>
          <com:city>MARLBOROUGH</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>01752</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>5082632900</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Schnittker Brandon</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>476</noOfUnitsSold>
        <aggregateMarketValue>39559.28</aggregateMarketValue>
        <noOfUnitsOutstanding>232271906</noOfUnitsOutstanding>
        <approxSaleDate>08/06/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/30/2022</acquiredDate>
        <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>172</amountOfSecuritiesAcquired>
        <paymentDate>12/30/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/29/2023</acquiredDate>
        <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>148</amountOfSecuritiesAcquired>
        <paymentDate>12/29/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/01/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>156</amountOfSecuritiesAcquired>
        <paymentDate>06/01/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>08/06/2024</noticeDate>
        <signature>/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Brandon Schnittker</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3862}]
text: 144
  0002006673
  XXXXXXXX
  LIVE
  0000859737
  HOLOGIC INC
  001-36214
  250 CAMPUS DRIVE
  MARLBOROUGH
  MA
  01752
  5082632900
  Schnittker Brandon
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  476
  39559.28
  232271906
  08/06/2024
  NASDAQ
  Common
  12/30/2022
  ESPP Purchase
  Issuer
  N
  172
  12/30/2022
  Cash
  Common
  12/29/2023
  ESPP Purchase
  Issuer
  N
  148
  12/29/2023
  Cash
  Common
  06/01/2024
  Restricted Stock Vesting
  Issuer
  N
  156
  06/01/2024
  Compensation
  Y
  08/06/2024
  /s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Brandon Schnittker