content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001493858</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001374310</issuerCik>
        <issuerName>Cboe Global Markets, Inc.</issuerName>
        <secFileNumber>001-34774</secFileNumber>
        <issuerAddress>
          <com:street1>433 WEST VAN BUREN STREET</com:street1>
          <com:city>CHICAGO</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60607</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>312 786 7200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Tilly Edward T</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>common (from Call contracts)</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Rockefeller Financial LLC</name>
          <address>
            <com:street1>227 W Monroe St</com:street1>
            <com:street2>STE 2050</com:street2>
            <com:city>Chicago</com:city>
            <com:stateOrCountry>IL</com:stateOrCountry>
            <com:zipCode>60010</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>10000</noOfUnitsSold>
        <aggregateMarketValue>1780000.00</aggregateMarketValue>
        <noOfUnitsOutstanding>105555989</noOfUnitsOutstanding>
        <approxSaleDate>12/08/2023</approxSaleDate>
        <securitiesExchangeName>other</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/19/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>N/A</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
        <paymentDate>02/19/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Edward Tilly Rev Trust</name>
          <address>
            <com:street1>417 Caeser Dr</com:street1>
            <com:city>Barrington</com:city>
            <com:stateOrCountry>IL</com:stateOrCountry>
            <com:zipCode>60010</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>common</securitiesClassTitle>
        <saleDate>11/03/2023</saleDate>
        <amountOfSecuritiesSold>70000</amountOfSecuritiesSold>
        <grossProceeds>11682769.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Edward Tilly Rev Trust</name>
          <address>
            <com:street1>417 Caeser Dr</com:street1>
            <com:city>Barrington</com:city>
            <com:stateOrCountry>IL</com:stateOrCountry>
            <com:zipCode>60010</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>common</securitiesClassTitle>
        <saleDate>11/06/2023</saleDate>
        <amountOfSecuritiesSold>30000</amountOfSecuritiesSold>
        <grossProceeds>5229466.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Edward tilly Rev Trust</name>
          <address>
            <com:street1>417 Ceaser Dr</com:street1>
            <com:city>Barrington</com:city>
            <com:stateOrCountry>IL</com:stateOrCountry>
            <com:zipCode>60010</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>common</securitiesClassTitle>
        <saleDate>11/10/2023</saleDate>
        <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
        <grossProceeds>900000.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Edward Tilly Rev Trust</name>
          <address>
            <com:street1>417 Caeser Dr</com:street1>
            <com:city>Barrington</com:city>
            <com:stateOrCountry>IL</com:stateOrCountry>
            <com:zipCode>60010</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>11/13/2023</saleDate>
        <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
        <grossProceeds>1800000.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Edward Tilly Rev Trust</name>
          <address>
            <com:street1>417 Caeser Dr</com:street1>
            <com:city>Barrington</com:city>
            <com:stateOrCountry>IL</com:stateOrCountry>
            <com:zipCode>60010</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>11/21/2023</saleDate>
        <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
        <grossProceeds>1798291.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Edward Tilly Rev Trust</name>
          <address>
            <com:street1>417 Caeser Dr</com:street1>
            <com:city>Barrington</com:city>
            <com:stateOrCountry>IL</com:stateOrCountry>
            <com:zipCode>60010</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>11/28/2023</saleDate>
        <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
        <grossProceeds>1700000.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/08/2023</noticeDate>
        <signature>Jason Coleman as a duly authorized representative of National Financial Services LLC, as attorney-in-fact for Edward Tilly</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6410}]
text: 144
  0001493858
  XXXXXXXX
  LIVE
  0001374310
  Cboe Global Markets, Inc.
  001-34774
  433 WEST VAN BUREN STREET
  CHICAGO
  IL
  60607
  312 786 7200
  Tilly Edward T
  Officer
  common (from Call contracts)
  Rockefeller Financial LLC
  227 W Monroe St
  STE 2050
  Chicago
  IL
  60010
  10000
  1780000.00
  105555989
  12/08/2023
  other
  Common
  02/19/2022
  Stock Award
  N/A
  N
  10000
  02/19/2022
  Cash
  N
  Edward Tilly Rev Trust
  417 Caeser Dr
  Barrington
  IL
  60010
  common
  11/03/2023
  70000
  11682769.00
  Edward Tilly Rev Trust
  417 Caeser Dr
  Barrington
  IL
  60010
  common
  11/06/2023
  30000
  5229466.00
  Edward tilly Rev Trust
  417 Ceaser Dr
  Barrington
  IL
  60010
  common
  11/10/2023
  5000
  900000.00
  Edward Tilly Rev Trust
  417 Caeser Dr
  Barrington
  IL
  60010
  Common
  11/13/2023
  10000
  1800000.00
  Edward Tilly Rev Trust
  417 Caeser Dr
  Barrington
  IL
  60010
  Common
  11/21/2023
  10000
  1798291.00
  Edward Tilly Rev Trust
  417 Caeser Dr
  Barrington
  IL
  60010
  Common
  11/28/2023
  10000
  1700000.00
  12/08/2023
  Jason Coleman as a duly authorized representative of National Financial Services LLC, as attorney-in-fact for Edward Tilly