content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001780270</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001679363</issuerCik>
        <issuerName>MORPHIC HOLDING, INC.</issuerName>
        <secFileNumber>001-38940</secFileNumber>
        <issuerAddress>
          <com:street1>35 Gatehouse Drive</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>7819960955</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>William DeVaul</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>360 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>11658</noOfUnitsSold>
        <aggregateMarketValue>665322</aggregateMarketValue>
        <noOfUnitsOutstanding>39691960</noOfUnitsOutstanding>
        <approxSaleDate>05/23/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>common</securitiesClassTitle>
        <acquiredDate>09/01/2021</acquiredDate>
        <natureOfAcquisitionTransaction>ESPP</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4206</amountOfSecuritiesAcquired>
        <paymentDate>09/01/2021</paymentDate>
        <natureOfPayment>cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/01/2021</acquiredDate>
        <natureOfAcquisitionTransaction>stock option exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>7452</amountOfSecuritiesAcquired>
        <paymentDate>12/01/2021</paymentDate>
        <natureOfPayment>cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/23/2023</noticeDate>
        <signature>/s/ JPMS LLC as agent and attorney-in-fact for William DeVaul</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3299}]
text: 144
  0001780270
  XXXXXXXX
  LIVE
  0001679363
  MORPHIC HOLDING, INC.
  001-38940
  35 Gatehouse Drive
  Waltham
  MA
  02451
  7819960955
  William DeVaul
  affiliate
  Common
  J.P. Morgan Securities LLC
  360 Madison Avenue - 6th Floor
  New York
  NY
  10017
  11658
  665322
  39691960
  05/23/2023
  Nasdaq
  common
  09/01/2021
  ESPP
  Issuer
  N
  4206
  09/01/2021
  cash
  Common
  12/01/2021
  stock option exercise
  Issuer
  N
  7452
  12/01/2021
  cash
  Y
  05/23/2023
  /s/ JPMS LLC as agent and attorney-in-fact for William DeVaul