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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001801047</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001787306</issuerCik>
        <issuerName>Arcutis Biotherapeutics, Inc.</issuerName>
        <secFileNumber>001-39186</secFileNumber>
        <issuerAddress>
          <com:street1>3027 TOWNSGATE ROAD</com:street1>
          <com:street2>SUITE 300</com:street2>
          <com:city>WESTLAKE VILLAGE</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91361</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>805-418-5006</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Lock Kenneth A.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Merrill</name>
          <address>
            <com:street1>8890 Lyra Dr 5th Floor</com:street1>
            <com:city>Columbus</com:city>
            <com:stateOrCountry>OH</com:stateOrCountry>
            <com:zipCode>43240</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>130419</noOfUnitsSold>
        <aggregateMarketValue>1102040.00</aggregateMarketValue>
        <noOfUnitsOutstanding>61653978</noOfUnitsOutstanding>
        <approxSaleDate>08/15/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>common</securitiesClassTitle>
        <acquiredDate>10/28/2019</acquiredDate>
        <natureOfAcquisitionTransaction>Stock option exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>130419</amountOfSecuritiesAcquired>
        <paymentDate>08/15/2023</paymentDate>
        <natureOfPayment>cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>08/15/2023</noticeDate>
        <signature>Kenneth Lock</signature>
      </noticeSignature>
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text: 144
  0001801047
  XXXXXXXX
  LIVE
  0001787306
  Arcutis Biotherapeutics, Inc.
  001-39186
  3027 TOWNSGATE ROAD
  SUITE 300
  WESTLAKE VILLAGE
  CA
  91361
  805-418-5006
  Lock Kenneth A.
  Former officer
  Common
  Merrill
  8890 Lyra Dr 5th Floor
  Columbus
  OH
  43240
  130419
  1102040.00
  61653978
  08/15/2023
  NASDAQ
  common
  10/28/2019
  Stock option exercise
  Arcutis Biotherapeutics
  N
  130419
  08/15/2023
  cash
  Y
  08/15/2023
  Kenneth Lock