content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001744425</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001737953</issuerCik>
        <issuerName>Replimune Group Inc.</issuerName>
        <secFileNumber>001-38596</secFileNumber>
        <issuerAddress>
          <com:street1>500 Unicorn Park Drive</com:street1>
          <com:street2>Suite 303</com:street2>
          <com:city>Woburn</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>01801</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>7812229600</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Pamela Esposito</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>79710</noOfUnitsSold>
        <aggregateMarketValue>472680</aggregateMarketValue>
        <noOfUnitsOutstanding>61415105</noOfUnitsOutstanding>
        <approxSaleDate>05/23/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/23/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>45716</amountOfSecuritiesAcquired>
        <paymentDate>05/23/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Rsetricted Stock Units</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>5034</amountOfSecuritiesAcquired>
        <paymentDate>05/15/2022</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/15/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Rsetricted Stock Units</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4960</amountOfSecuritiesAcquired>
        <paymentDate>05/15/2023</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/23/2020</acquiredDate>
        <natureOfAcquisitionTransaction>Exercised Stock Options ( ISO)</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>24000</amountOfSecuritiesAcquired>
        <paymentDate>12/23/2020</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>A portion of the sales  under this filing are from Cashless Option Exercises that will occur within 3 months from the date of  this filing.</remarks>
      <noticeSignature>
        <noticeDate>05/23/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>02/21/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Pamela Esposito</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4751}]
text: 144
  0001744425
  XXXXXXXX
  LIVE
  0001737953
  Replimune Group Inc.
  001-38596
  500 Unicorn Park Drive
  Suite 303
  Woburn
  MA
  01801
  7812229600
  Pamela Esposito
  Officer
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  79710
  472680
  61415105
  05/23/2024
  Nasdaq
  Common
  05/23/2024
  Stock Option Exercise
  Issuer
  N
  45716
  05/23/2024
  Cash
  Common
  05/15/2022
  Rsetricted Stock Units
  Issuer
  N
  5034
  05/15/2022
  NA
  Common
  05/15/2023
  Rsetricted Stock Units
  Issuer
  N
  4960
  05/15/2023
  NA
  Common
  12/23/2020
  Exercised Stock Options ( ISO)
  Issuer
  N
  24000
  12/23/2020
  Cash
  Y
  A portion of the sales  under this filing are from Cashless Option Exercises that will occur within 3 months from the date of  this filing.
  05/23/2024
  02/21/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Pamela Esposito