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        <secFileNumber>001-42009</secFileNumber>
        <issuerAddress>
          <com:street1>11250 EL CAMINO REAL, SUITE 100</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
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        <issuerContactPhone>(858) 410-0266</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ARSENAULT KAITLYN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
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          <name>Piper Sandler &amp; Co Inc</name>
          <address>
            <com:street1>800 Nicollet Mall</com:street1>
            <com:city>Minneapolis</com:city>
            <com:stateOrCountry>MN</com:stateOrCountry>
            <com:zipCode>55402</com:zipCode>
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        <aggregateMarketValue>314532.84</aggregateMarketValue>
        <noOfUnitsOutstanding>30338290</noOfUnitsOutstanding>
        <approxSaleDate>11/15/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>11/15/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>57084</amountOfSecuritiesAcquired>
        <paymentDate>11/15/2024</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
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      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/15/2024</noticeDate>
        <signature>Alex Johnson, a duly authorized representative of Piper Sandler &amp; Co Corporate &amp; Venture Services FA, as attorney-in-fact for Kaitlyn Arsenault</signature>
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text: 144
  0001877242
  XXXXXXXX
  LIVE
  0001516551
  Skye Bioscience, Inc.
  001-42009
  11250 EL CAMINO REAL, SUITE 100
  SAN DIEGO
  CA
  92130
  (858) 410-0266
  ARSENAULT KAITLYN
  Officer
  Common Stock
  Piper Sandler & Co Inc
  800 Nicollet Mall
  Minneapolis
  MN
  55402
  57084
  314532.84
  30338290
  11/15/2024
  Nasdaq
  Common Stock
  11/15/2024
  Compensation
  Issuer
  N
  57084
  11/15/2024
  NA
  Y
  11/15/2024
  Alex Johnson, a duly authorized representative of Piper Sandler & Co Corporate & Venture Services FA, as attorney-in-fact for Kaitlyn Arsenault