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        <filer>
          <filerCredentials>
            <cik>0001974794</cik>
            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001830749</issuerCik>
        <issuerName>Achilles Therapeutics plc</issuerName>
        <secFileNumber>001-40299</secFileNumber>
        <issuerAddress>
          <com:street1>245 HAMMERSMITH ROAD</com:street1>
          <com:city>LONDON</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>W6 8PW</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>44 (0)20 8154 4600</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Peggs Karl Stuart Dr</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>ADS</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Piper Sandler &amp; Co.</name>
          <address>
            <com:street1>800 Nicollet Mall, Ste 900</com:street1>
            <com:city>Minneapolis</com:city>
            <com:stateOrCountry>MN</com:stateOrCountry>
            <com:zipCode>55402</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>35000</noOfUnitsSold>
        <aggregateMarketValue>32735.00</aggregateMarketValue>
        <noOfUnitsOutstanding>4095000</noOfUnitsOutstanding>
        <approxSaleDate>08/17/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>ADSs</securitiesClassTitle>
        <acquiredDate>05/24/2016</acquiredDate>
        <natureOfAcquisitionTransaction>Vested RSU's</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>35000</amountOfSecuritiesAcquired>
        <paymentDate>05/24/2016</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>08/17/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>05/19/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Linda Moran, as a duly authorized representative of Piper Sandler &amp; Co Corporate &amp; Venture Services FA, as attorney-in-fact for Karl Stuart Peggs</signature>
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text: 144
  0001974794
  XXXXXXXX
  LIVE
  0001830749
  Achilles Therapeutics plc
  001-40299
  245 HAMMERSMITH ROAD
  LONDON
  X0
  W6 8PW
  44 (0)20 8154 4600
  Peggs Karl Stuart Dr
  Officer
  ADS
  Piper Sandler & Co.
  800 Nicollet Mall, Ste 900
  Minneapolis
  MN
  55402
  35000
  32735.00
  4095000
  08/17/2023
  NASDAQ
  ADSs
  05/24/2016
  Vested RSU's
  Issuer
  N
  35000
  05/24/2016
  Compensation
  Y
  08/17/2023
  05/19/2023
  /s/ Linda Moran, as a duly authorized representative of Piper Sandler & Co Corporate & Venture Services FA, as attorney-in-fact for Karl Stuart Peggs