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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerName>IDEAYA Biosciences, Inc.</issuerName>
        <secFileNumber>001-38915</secFileNumber>
        <issuerAddress>
          <com:street1>7000 Shoreline Court</com:street1>
          <com:street2>Suite 350</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>6504436209</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Andres Ruiz Briseno</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Senior VP</relationshipToIssuer>
        </relationshipsToIssuer>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
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        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>4000</noOfUnitsSold>
        <aggregateMarketValue>149480</aggregateMarketValue>
        <noOfUnitsOutstanding>64459472</noOfUnitsOutstanding>
        <approxSaleDate>01/12/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/04/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4000</amountOfSecuritiesAcquired>
        <paymentDate>10/04/2021</paymentDate>
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            <com:street2>Suite 350</com:street2>
            <com:city>San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/14/2023</saleDate>
        <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
        <grossProceeds>68002</grossProceeds>
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      <noticeSignature>
        <noticeDate>01/12/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/30/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Andres Ruiz Briseno</signature>
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text: 144
  0001983118
  XXXXXXXX
  LIVE
  0001676725
  IDEAYA Biosciences, Inc.
  001-38915
  7000 Shoreline Court
  Suite 350
  San Francisco
  CA
  94080
  6504436209
  Andres Ruiz Briseno
  Senior VP
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  4000
  149480
  64459472
  01/12/2024
  Nasdaq
  Common
  10/04/2021
  Stock Option Exercise
  Issuer
  N
  4000
  10/04/2021
  Cash
  N
  Andres Ruiz Brisen
  7000 Shoreline Court
  Suite 350
  San Francisco
  CA
  94080
  Common
  12/14/2023
  2000
  68002
  01/12/2024
  03/30/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Andres Ruiz Briseno