content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001535065</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001534969</issuerCik>
        <issuerName>Sera Prognostics, Inc.</issuerName>
        <secFileNumber>001-40606</secFileNumber>
        <issuerAddress>
          <com:street1>2749 E. Parleys Way, Suite 200</com:street1>
          <com:city>Salt Lake City</com:city>
          <com:stateOrCountry>UT</com:stateOrCountry>
          <com:zipCode>84109</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>801-990-0520</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kim P. Kamdar</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>2398443</noOfUnitsSold>
        <aggregateMarketValue>11992215</aggregateMarketValue>
        <noOfUnitsOutstanding>30368753</noOfUnitsOutstanding>
        <approxSaleDate>12/14/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>11/08/2011</acquiredDate>
        <natureOfAcquisitionTransaction>Private Investment</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2398443</amountOfSecuritiesAcquired>
        <paymentDate>11/08/2011</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The shares in this filing will be sold from Domain Partners VIII, L.P. and the shares were acquired between 11/08/2011 and 07/31/2019</remarks>
      <noticeSignature>
        <noticeDate>12/14/2023</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Kim P. Kamdar</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001535065
  XXXXXXXX
  LIVE
  0001534969
  Sera Prognostics, Inc.
  001-40606
  2749 E. Parleys Way, Suite 200
  Salt Lake City
  UT
  84109
  801-990-0520
  Kim P. Kamdar
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  2398443
  11992215
  30368753
  12/14/2023
  NASDAQ
  Common
  11/08/2011
  Private Investment
  Issuer
  N
  2398443
  11/08/2011
  Cash
  Y
  The shares in this filing will be sold from Domain Partners VIII, L.P. and the shares were acquired between 11/08/2011 and 07/31/2019
  12/14/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Kim P. Kamdar