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        <secFileNumber>001-40097</secFileNumber>
        <issuerAddress>
          <com:street1>27 DRYDOCK AVENUE</com:street1>
          <com:street2>8TH FLOOR</com:street2>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(877) 442-5362</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>HENRY CHRISTIAN O</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
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      <securitiesInformation>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>4499</noOfUnitsSold>
        <aggregateMarketValue>10032.77</aggregateMarketValue>
        <noOfUnitsOutstanding>1600988177</noOfUnitsOutstanding>
        <approxSaleDate>09/05/2023</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
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        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>09/01/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4499</amountOfSecuritiesAcquired>
        <paymentDate>09/01/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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          <name>Christian Henry</name>
          <address>
            <com:street1>27 Drydock Avenue</com:street1>
            <com:street2>8th Floor</com:street2>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <saleDate>06/12/2023</saleDate>
        <amountOfSecuritiesSold>39007</amountOfSecuritiesSold>
        <grossProceeds>71772.88</grossProceeds>
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        <sellerDetails>
          <name>Christian Henry</name>
          <address>
            <com:street1>27 Drydock Avenue</com:street1>
            <com:street2>8th Floor</com:street2>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <saleDate>07/03/2023</saleDate>
        <amountOfSecuritiesSold>4499</amountOfSecuritiesSold>
        <grossProceeds>8503.11</grossProceeds>
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          <name>Christian Henry</name>
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            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02210</com:zipCode>
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        <securitiesClassTitle>Class A</securitiesClassTitle>
        <saleDate>08/02/2023</saleDate>
        <amountOfSecuritiesSold>4499</amountOfSecuritiesSold>
        <grossProceeds>10122.75</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>09/05/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>09/15/2022</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Christian Henry</signature>
      </noticeSignature>
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text: 144
  0001263805
  XXXXXXXX
  LIVE
  0001830214
  Ginkgo Bioworks Holdings, Inc.
  001-40097
  27 DRYDOCK AVENUE
  8TH FLOOR
  BOSTON
  MA
  02210
  (877) 442-5362
  HENRY CHRISTIAN O
  Director
  Class A
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  4499
  10032.77
  1600988177
  09/05/2023
  NYSE
  Class A
  09/01/2023
  Restricted Stock Vesting
  Issuer
  N
  4499
  09/01/2023
  Compensation
  N
  Christian Henry
  27 Drydock Avenue
  8th Floor
  Boston
  MA
  02210
  Class A
  06/12/2023
  39007
  71772.88
  Christian Henry
  27 Drydock Avenue
  8th Floor
  Boston
  MA
  02210
  Class A
  07/03/2023
  4499
  8503.11
  Christian Henry
  27 Drydock Avenue
  8th Floor
  Boston
  MA
  02210
  Class A
  08/02/2023
  4499
  10122.75
  09/05/2023
  09/15/2022
  /s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Christian Henry