content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001786322</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001745999</issuerCik>
        <issuerName>Beam Therapeutics Inc.</issuerName>
        <secFileNumber>001-39208</secFileNumber>
        <issuerAddress>
          <com:street1>238 Main Street</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>857-327-8775</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Giuseppe Ciaramella</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>165590</noOfUnitsSold>
        <aggregateMarketValue>5310471.3</aggregateMarketValue>
        <noOfUnitsOutstanding>76217463</noOfUnitsOutstanding>
        <approxSaleDate>07/21/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/31/2023</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6328</amountOfSecuritiesAcquired>
        <paymentDate>03/31/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/17/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>18012</amountOfSecuritiesAcquired>
        <paymentDate>09/17/2021</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/29/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>39700</amountOfSecuritiesAcquired>
        <paymentDate>12/29/2021</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/21/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>101550</amountOfSecuritiesAcquired>
        <paymentDate>07/21/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>This filing is for long shares, RSU vesting, and option exercises during 07/21/23 - 10/02/23</remarks>
      <noticeSignature>
        <noticeDate>07/21/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/17/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Giuseppe Ciaramella</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4613}]
text: 144
  0001786322
  XXXXXXXX
  LIVE
  0001745999
  Beam Therapeutics Inc.
  001-39208
  238 Main Street
  Cambridge
  MA
  02142
  857-327-8775
  Giuseppe Ciaramella
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  165590
  5310471.3
  76217463
  07/21/2023
  NASDAQ
  Common
  03/31/2023
  RSU Vesting
  Issuer
  N
  6328
  03/31/2023
  Compensation
  Common
  09/17/2021
  Option Exercise
  Issuer
  N
  18012
  09/17/2021
  Cash
  Common
  12/29/2021
  Option Exercise
  Issuer
  N
  39700
  12/29/2021
  Cash
  Common
  07/21/2023
  Option Exercise
  Issuer
  N
  101550
  07/21/2023
  Cash
  Y
  This filing is for long shares, RSU vesting, and option exercises during 07/21/23 - 10/02/23
  07/21/2023
  03/17/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Giuseppe Ciaramella