content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001855684</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001826457</issuerCik>
        <issuerName>Monte Rosa Therapeutics, Inc.</issuerName>
        <secFileNumber>001-40522</secFileNumber>
        <issuerAddress>
          <com:street1>321 HARRISON AVENUE</com:street1>
          <com:street2>SUITE 900</com:street2>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02118</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-949-2643</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Tamboli Ajim</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Recently departed CFO</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Morgan Stanley Smith Barney LLC</name>
          <address>
            <com:street1>1 New York Plaza</com:street1>
            <com:street2>38th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10004</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>411861</noOfUnitsSold>
        <aggregateMarketValue>2677096.00</aggregateMarketValue>
        <noOfUnitsOutstanding>49659338</noOfUnitsOutstanding>
        <approxSaleDate>08/15/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/15/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>411861</amountOfSecuritiesAcquired>
        <paymentDate>08/15/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>This Form 144 is being filed for the cashless exercise of options and subsequent sales of the underlying shares commencing on 8/15/2023.</remarks>
      <noticeSignature>
        <noticeDate>08/15/2023</noticeDate>
        <signature>/s/ AJIM TAMBOLI</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3005}]
text: 144
  0001855684
  XXXXXXXX
  LIVE
  0001826457
  Monte Rosa Therapeutics, Inc.
  001-40522
  321 HARRISON AVENUE
  SUITE 900
  BOSTON
  MA
  02118
  617-949-2643
  Tamboli Ajim
  Recently departed CFO
  Common
  Morgan Stanley Smith Barney LLC
  1 New York Plaza
  38th Floor
  New York
  NY
  10004
  411861
  2677096.00
  49659338
  08/15/2023
  NASDAQ
  Common
  08/15/2023
  Exercise of options under a registered plan
  Issuer
  N
  411861
  08/15/2023
  Cash
  Y
  This Form 144 is being filed for the cashless exercise of options and subsequent sales of the underlying shares commencing on 8/15/2023.
  08/15/2023
  /s/ AJIM TAMBOLI