content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001675101</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000350698</issuerCik>
        <issuerName>AUTONATION, INC.</issuerName>
        <secFileNumber>001-13107</secFileNumber>
        <issuerAddress>
          <com:street1>200 SW 1ST AVE</com:street1>
          <com:street2>SUITE 1600</com:street2>
          <com:city>FORT LAUDERDALE</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33301</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>9547696000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CANNON MARC G</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Merrill Lynch</name>
          <address>
            <com:street1>3455 Peachtree Road NE</com:street1>
            <com:street2>Suite 1000</com:street2>
            <com:city>Atlanta</com:city>
            <com:stateOrCountry>GA</com:stateOrCountry>
            <com:zipCode>30326</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3000</noOfUnitsSold>
        <aggregateMarketValue>411990.30</aggregateMarketValue>
        <noOfUnitsOutstanding>45608396</noOfUnitsOutstanding>
        <approxSaleDate>05/26/2023</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/01/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Vesting of a Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Autonation, Inc.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3000</amountOfSecuritiesAcquired>
        <paymentDate>02/15/2022</paymentDate>
        <natureOfPayment>Compensatory Payment</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Marc Cannon</name>
          <address>
            <com:street1>200 SW 1st Avenue</com:street1>
            <com:city>Fort Lauderdale</com:city>
            <com:stateOrCountry>FL</com:stateOrCountry>
            <com:zipCode>33301</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>03/08/2023</saleDate>
        <amountOfSecuritiesSold>3000</amountOfSecuritiesSold>
        <grossProceeds>426000.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Marc Cannon</name>
          <address>
            <com:street1>200 SW 1st Avenue</com:street1>
            <com:city>Fort Lauderdale</com:city>
            <com:stateOrCountry>FL</com:stateOrCountry>
            <com:zipCode>33301</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>03/09/2023</saleDate>
        <amountOfSecuritiesSold>5800</amountOfSecuritiesSold>
        <grossProceeds>838200.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/26/2023</noticeDate>
        <signature>Marc Cannon</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3983}]
text: 144
  0001675101
  XXXXXXXX
  LIVE
  0000350698
  AUTONATION, INC.
  001-13107
  200 SW 1ST AVE
  SUITE 1600
  FORT LAUDERDALE
  FL
  33301
  9547696000
  CANNON MARC G
  Former Officer
  Common
  Merrill Lynch
  3455 Peachtree Road NE
  Suite 1000
  Atlanta
  GA
  30326
  3000
  411990.30
  45608396
  05/26/2023
  NYSE
  Common
  03/01/2023
  Vesting of a Stock Award
  Autonation, Inc.
  N
  3000
  02/15/2022
  Compensatory Payment
  N
  Marc Cannon
  200 SW 1st Avenue
  Fort Lauderdale
  FL
  33301
  Common
  03/08/2023
  3000
  426000.00
  Marc Cannon
  200 SW 1st Avenue
  Fort Lauderdale
  FL
  33301
  Common
  03/09/2023
  5800
  838200.00
  05/26/2023
  Marc Cannon