content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001987926</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000318154</issuerCik>
        <issuerName>AMGEN INC</issuerName>
        <secFileNumber>001-37702</secFileNumber>
        <issuerAddress>
          <com:street1>ONE AMGEN CENTER DRIVE</com:street1>
          <com:city>THOUSAND OAKS</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91320</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(805)447-1000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Busch Matthew C.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>FIDELITY BROKERAGE SERVICES LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>BOSTON</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1000</noOfUnitsSold>
        <aggregateMarketValue>281440.00</aggregateMarketValue>
        <noOfUnitsOutstanding>537706118</noOfUnitsOutstanding>
        <approxSaleDate>05/02/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/18/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>326</amountOfSecuritiesAcquired>
        <paymentDate>03/18/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>11/06/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>354</amountOfSecuritiesAcquired>
        <paymentDate>11/06/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/07/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>46</amountOfSecuritiesAcquired>
        <paymentDate>05/07/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/03/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>47</amountOfSecuritiesAcquired>
        <paymentDate>05/03/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/01/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>28</amountOfSecuritiesAcquired>
        <paymentDate>05/01/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/19/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>199</amountOfSecuritiesAcquired>
        <paymentDate>03/19/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>shares sold out of  Busch Family Trust by Matthew Busch</remarks>
      <noticeSignature>
        <noticeDate>05/02/2025</noticeDate>
        <signature>/s/ Jordyn Davis as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for  Busch Matthew C.</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5518}]
text: 144
  0001987926
  XXXXXXXX
  LIVE
  0000318154
  AMGEN INC
  001-37702
  ONE AMGEN CENTER DRIVE
  THOUSAND OAKS
  CA
  91320
  (805)447-1000
  Busch Matthew C.
  Officer
  Common
  FIDELITY BROKERAGE SERVICES LLC
  245 Summer Street
  BOSTON
  MA
  02110
  1000
  281440.00
  537706118
  05/02/2025
  NASDAQ
  Common
  03/18/2025
  Compensation
  Issuer
  N
  326
  03/18/2025
  Compensation
  Common
  11/06/2024
  Compensation
  Issuer
  N
  354
  11/06/2024
  Compensation
  Common
  05/07/2024
  Compensation
  Issuer
  N
  46
  05/07/2024
  Compensation
  Common
  05/03/2024
  Compensation
  Issuer
  N
  47
  05/03/2024
  Compensation
  Common
  05/01/2024
  Compensation
  Issuer
  N
  28
  05/01/2024
  Compensation
  Common
  03/19/2024
  Compensation
  Issuer
  N
  199
  03/19/2024
  Compensation
  Y
  shares sold out of  Busch Family Trust by Matthew Busch
  05/02/2025
  /s/ Jordyn Davis as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for  Busch Matthew C.