content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001672778</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001068851</issuerCik>
        <issuerName>PROSPERITY BANCSHARES INC</issuerName>
        <secFileNumber>001-35388</secFileNumber>
        <issuerAddress>
          <com:street1>4295 SAN FELIPE</com:street1>
          <com:street2>N/A</com:street2>
          <com:city>HOUSTON</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77027</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>7136939300</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>LORD L. JACK</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>2100</noOfUnitsSold>
        <aggregateMarketValue>133161.00</aggregateMarketValue>
        <noOfUnitsOutstanding>93714954</noOfUnitsOutstanding>
        <approxSaleDate>12/11/2023</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/01/2018</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1000</amountOfSecuritiesAcquired>
        <paymentDate>04/01/2018</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/20/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1100</amountOfSecuritiesAcquired>
        <paymentDate>04/20/2021</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Shares will be sold out of the following Trust Account: Lord Living Trust</remarks>
      <noticeSignature>
        <noticeDate>12/11/2023</noticeDate>
        <signature>/s/ Christian Nasser as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Jack Lord</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001672778
  XXXXXXXX
  LIVE
  0001068851
  PROSPERITY BANCSHARES INC
  001-35388
  4295 SAN FELIPE
  N/A
  HOUSTON
  TX
  77027
  7136939300
  LORD L. JACK
  Director
  Common
  Fidelity Brokerage Services LLC
  245 Summer Street
  Boston
  MA
  02110
  2100
  133161.00
  93714954
  12/11/2023
  NYSE
  Common
  04/01/2018
  Stock Award
  Issuer
  N
  1000
  04/01/2018
  Compensation
  Common
  04/20/2021
  Stock Award
  Issuer
  N
  1100
  04/20/2021
  Compensation
  Y
  Shares will be sold out of the following Trust Account: Lord Living Trust
  12/11/2023
  /s/ Christian Nasser as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Jack Lord