content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001793412</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001806310</issuerCik>
        <issuerName>Taysha Gene Therapies, Inc.</issuerName>
        <secFileNumber>001-39536</secFileNumber>
        <issuerAddress>
          <com:street1>3000 Pegasus Park Drive, Suite 1430</com:street1>
          <com:city>Dallas</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75247</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>214-612-0000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kamran Alam</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>JP Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>33000</noOfUnitsSold>
        <aggregateMarketValue>86460</aggregateMarketValue>
        <noOfUnitsOutstanding>64465037</noOfUnitsOutstanding>
        <approxSaleDate>08/24/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/17/2023</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>33000</amountOfSecuritiesAcquired>
        <paymentDate>08/17/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>08/24/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>05/26/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Kamran Alam</signature>
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text: 144
  0001793412
  XXXXXXXX
  LIVE
  0001806310
  Taysha Gene Therapies, Inc.
  001-39536
  3000 Pegasus Park Drive, Suite 1430
  Dallas
  TX
  75247
  214-612-0000
  Kamran Alam
  Officer
  Common Stock
  JP Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  33000
  86460
  64465037
  08/24/2023
  NASDAQ
  Common
  08/17/2023
  RSU Vesting
  Issuer
  N
  33000
  08/17/2023
  Compensation
  Y
  08/24/2023
  05/26/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Kamran Alam