content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001997598</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001374310</issuerCik>
        <issuerName>Cboe Global Markets, Inc.</issuerName>
        <secFileNumber>001-34774</secFileNumber>
        <issuerAddress>
          <com:street1>433 WEST VAN BUREN STREET</com:street1>
          <com:city>CHICAGO</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60607</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>312 786 7200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Inzirillo Adam</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>200</noOfUnitsSold>
        <aggregateMarketValue>41934.14</aggregateMarketValue>
        <noOfUnitsOutstanding>104685813</noOfUnitsOutstanding>
        <approxSaleDate>02/20/2025</approxSaleDate>
        <securitiesExchangeName>CboeBZX</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/19/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>200</amountOfSecuritiesAcquired>
        <paymentDate>02/19/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Adam Inzirillo</name>
          <address>
            <com:street1>433 West Van Buren Street</com:street1>
            <com:city>Chicago</com:city>
            <com:stateOrCountry>IL</com:stateOrCountry>
            <com:zipCode>60607</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/13/2024</saleDate>
        <amountOfSecuritiesSold>25</amountOfSecuritiesSold>
        <grossProceeds>5010.75</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Adam Inzirillo</name>
          <address>
            <com:street1>433 West Van Buren Street</com:street1>
            <com:city>Chicago</com:city>
            <com:stateOrCountry>IL</com:stateOrCountry>
            <com:zipCode>60607</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/10/2025</saleDate>
        <amountOfSecuritiesSold>80</amountOfSecuritiesSold>
        <grossProceeds>16932.80</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>02/20/2025</noticeDate>
        <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Adam Inzirillo </signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4008}]
text: 144
  0001997598
  XXXXXXXX
  LIVE
  0001374310
  Cboe Global Markets, Inc.
  001-34774
  433 WEST VAN BUREN STREET
  CHICAGO
  IL
  60607
  312 786 7200
  Inzirillo Adam
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  200
  41934.14
  104685813
  02/20/2025
  CboeBZX
  Common
  02/19/2024
  Restricted Stock Vesting
  Issuer
  N
  200
  02/19/2024
  Compensation
  N
  Adam Inzirillo
  433 West Van Buren Street
  Chicago
  IL
  60607
  Common
  12/13/2024
  25
  5010.75
  Adam Inzirillo
  433 West Van Buren Street
  Chicago
  IL
  60607
  Common
  02/10/2025
  80
  16932.80
  02/20/2025
  /s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Adam Inzirillo