content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001790865</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001676725</issuerCik>
        <issuerName>IDEAYA Biosciences, Inc.</issuerName>
        <secFileNumber>001-38915</secFileNumber>
        <issuerAddress>
          <com:street1>7000 Shoreline Court</com:street1>
          <com:street2>Suite 350</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>6504436209</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jason Throne</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>75000</noOfUnitsSold>
        <aggregateMarketValue>3016500</aggregateMarketValue>
        <noOfUnitsOutstanding>84481494</noOfUnitsOutstanding>
        <approxSaleDate>08/26/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/26/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>75000</amountOfSecuritiesAcquired>
        <paymentDate>08/26/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The sales under this filing are from Cashless Option Exercises that will occur within 3 months from the date of this filing.</remarks>
      <noticeSignature>
        <noticeDate>08/26/2024</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jason Throne</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001790865
  XXXXXXXX
  LIVE
  0001676725
  IDEAYA Biosciences, Inc.
  001-38915
  7000 Shoreline Court
  Suite 350
  San Francisco
  CA
  94080
  6504436209
  Jason Throne
  Former Officer
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  75000
  3016500
  84481494
  08/26/2024
  Nasdaq
  Common
  08/26/2024
  Stock Option Exercise
  Issuer
  N
  75000
  08/26/2024
  Cash
  Y
  The sales under this filing are from Cashless Option Exercises that will occur within 3 months from the date of this filing.
  08/26/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jason Throne