content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001876820</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001651625</issuerCik>
        <issuerName>AC Immune SA</issuerName>
        <secFileNumber>001-37891</secFileNumber>
        <issuerAddress>
          <com:street1>EPFL INNOVATION PARK, BUILDING B</com:street1>
          <com:city>1015 LAUSANNE</com:city>
          <com:stateOrCountry>V8</com:stateOrCountry>
          <com:zipCode>00000</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>41 21 345 91 21</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>AFFIRIS AG in Liqu</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>William Blair &amp; Company LLC</name>
          <address>
            <com:street1>150 N Riverside Plaza</com:street1>
            <com:city>Chicage</com:city>
            <com:stateOrCountry>IL</com:stateOrCountry>
            <com:zipCode>60643</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>150000</noOfUnitsSold>
        <aggregateMarketValue>499500.00</aggregateMarketValue>
        <noOfUnitsOutstanding>98749352</noOfUnitsOutstanding>
        <approxSaleDate>05/16/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/15/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Merger/acquisition</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>AC immune</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6578100</amountOfSecuritiesAcquired>
        <paymentDate>10/15/2021</paymentDate>
        <natureOfPayment>n/a</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Shares are being sold from AFFIRIS AG account</remarks>
      <noticeSignature>
        <noticeDate>05/16/2024</noticeDate>
        <signature>/s/ Audrey Skillern as a duly authorized representative of National Financial Services LLC, as attorney-in-fact for Claus Schalper</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2921}]
text: 144
  0001876820
  XXXXXXXX
  LIVE
  0001651625
  AC Immune SA
  001-37891
  EPFL INNOVATION PARK, BUILDING B
  1015 LAUSANNE
  V8
  00000
  41 21 345 91 21
  AFFIRIS AG in Liqu
  10% Stockholder
  Common
  William Blair & Company LLC
  150 N Riverside Plaza
  Chicage
  IL
  60643
  150000
  499500.00
  98749352
  05/16/2024
  NASDAQ
  Common
  10/15/2021
  Merger/acquisition
  AC immune
  N
  6578100
  10/15/2021
  n/a
  Y
  Shares are being sold from AFFIRIS AG account
  05/16/2024
  /s/ Audrey Skillern as a duly authorized representative of National Financial Services LLC, as attorney-in-fact for Claus Schalper