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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001772130</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001821586</issuerCik>
        <issuerName>MoonLake Immunotherapeutics</issuerName>
        <secFileNumber>001-39630</secFileNumber>
        <issuerAddress>
          <com:street1>DORFSTRASSE 29</com:street1>
          <com:city>ZUG</com:city>
          <com:stateOrCountry>V8</com:stateOrCountry>
          <com:zipCode>6300</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>41 41 510 8022</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Moukheibir Catherine</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>23500</noOfUnitsSold>
        <aggregateMarketValue>1146594.65</aggregateMarketValue>
        <noOfUnitsOutstanding>63474253</noOfUnitsOutstanding>
        <approxSaleDate>07/03/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>07/03/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted - 04/06/2022</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>23500</amountOfSecuritiesAcquired>
        <paymentDate>07/03/2025</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>07/03/2025</noticeDate>
        <signature>/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Catherine Moukheibir</signature>
      </noticeSignature>
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text: 144
  0001772130
  XXXXXXXX
  LIVE
  0001821586
  MoonLake Immunotherapeutics
  001-39630
  DORFSTRASSE 29
  ZUG
  V8
  6300
  41 41 510 8022
  Moukheibir Catherine
  Director
  Class A
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  23500
  1146594.65
  63474253
  07/03/2025
  NASDAQ
  Class A
  07/03/2025
  Option Granted - 04/06/2022
  Issuer
  N
  23500
  07/03/2025
  Cash
  Y
  07/03/2025
  /s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Catherine Moukheibir