content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001544050</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001423689</issuerCik>
        <issuerName>AGNC Investment Corp.</issuerName>
        <secFileNumber>001-34057</secFileNumber>
        <issuerAddress>
          <com:street1>7373 WISCONSIN AVENUE, 22ND FLOOR</com:street1>
          <com:city>BETHESDA</com:city>
          <com:stateOrCountry>MD</com:stateOrCountry>
          <com:zipCode>20814</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>301 968 9300</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kuehl Christopher</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>125000</noOfUnitsSold>
        <aggregateMarketValue>1126253.35</aggregateMarketValue>
        <noOfUnitsOutstanding>900421216</noOfUnitsOutstanding>
        <approxSaleDate>04/28/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/01/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>60568</amountOfSecuritiesAcquired>
        <paymentDate>03/01/2021</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/08/2016</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1</amountOfSecuritiesAcquired>
        <paymentDate>08/08/2016</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/08/2016</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1776</amountOfSecuritiesAcquired>
        <paymentDate>07/08/2016</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>41965</amountOfSecuritiesAcquired>
        <paymentDate>02/15/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/05/2016</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>13990</amountOfSecuritiesAcquired>
        <paymentDate>03/05/2016</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/30/2016</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4907</amountOfSecuritiesAcquired>
        <paymentDate>03/30/2016</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/09/2016</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1793</amountOfSecuritiesAcquired>
        <paymentDate>03/09/2016</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Christopher Kuehl</name>
          <address>
            <com:street1>7373 Wisconsin Avenue</com:street1>
            <com:street2>22nd Floor</com:street2>
            <com:city>Bethesda</com:city>
            <com:stateOrCountry>MD</com:stateOrCountry>
            <com:zipCode>20814</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/25/2025</saleDate>
        <amountOfSecuritiesSold>148286</amountOfSecuritiesSold>
        <grossProceeds>1301949.63</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>04/28/2025</noticeDate>
        <signature>/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Christopher Kuehl</signature>
      </noticeSignature>
    </formData>
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metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6731}]
text: 144
  0001544050
  XXXXXXXX
  LIVE
  0001423689
  AGNC Investment Corp.
  001-34057
  7373 WISCONSIN AVENUE, 22ND FLOOR
  BETHESDA
  MD
  20814
  301 968 9300
  Kuehl Christopher
  Former Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  125000
  1126253.35
  900421216
  04/28/2025
  NASDAQ
  Common
  03/01/2021
  Restricted Stock Vesting
  Issuer
  N
  60568
  03/01/2021
  Compensation
  Common
  08/08/2016
  Restricted Stock Vesting
  Issuer
  N
  1
  08/08/2016
  Compensation
  Common
  07/08/2016
  Restricted Stock Vesting
  Issuer
  N
  1776
  07/08/2016
  Compensation
  Common
  02/15/2022
  Restricted Stock Vesting
  Issuer
  N
  41965
  02/15/2022
  Compensation
  Common
  03/05/2016
  Restricted Stock Vesting
  Issuer
  N
  13990
  03/05/2016
  Compensation
  Common
  03/30/2016
  Restricted Stock Vesting
  Issuer
  N
  4907
  03/30/2016
  Compensation
  Common
  03/09/2016
  Restricted Stock Vesting
  Issuer
  N
  1793
  03/09/2016
  Compensation
  N
  Christopher Kuehl
  7373 Wisconsin Avenue
  22nd Floor
  Bethesda
  MD
  20814
  Common
  04/25/2025
  148286
  1301949.63
  04/28/2025
  /s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Christopher Kuehl