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      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001496687</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
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      <issuerInfo>
        <issuerCik>0001492422</issuerCik>
        <issuerName>Apellis Pharmaceuticals, Inc.</issuerName>
        <secFileNumber>001-38276</secFileNumber>
        <issuerAddress>
          <com:street1>100 FIFTH AVENUE</com:street1>
          <com:city>WALTHAM</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-977-5700</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Machiels Alec</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1250</noOfUnitsSold>
        <aggregateMarketValue>60625.00</aggregateMarketValue>
        <noOfUnitsOutstanding>117737289</noOfUnitsOutstanding>
        <approxSaleDate>10/17/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/17/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted 12/05/2013</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1250</amountOfSecuritiesAcquired>
        <paymentDate>10/17/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Alec Machiels</name>
          <address>
            <com:street1>100 Fifth Avenue</com:street1>
            <com:city>Waltham</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02451</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/18/2023</saleDate>
        <amountOfSecuritiesSold>1250</amountOfSecuritiesSold>
        <grossProceeds>56250.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Alec Machiels</name>
          <address>
            <com:street1>100 Fifth Avenue</com:street1>
            <com:city>Waltham</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02451</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/15/2023</saleDate>
        <amountOfSecuritiesSold>1250</amountOfSecuritiesSold>
        <grossProceeds>56675.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Alec Machiels</name>
          <address>
            <com:street1>100 Fifth Avenue</com:street1>
            <com:city>Waltham</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02451</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>07/17/2023</saleDate>
        <amountOfSecuritiesSold>1250</amountOfSecuritiesSold>
        <grossProceeds>80987.50</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>10/17/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>12/16/2022</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Alec Machiels</signature>
      </noticeSignature>
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text: 144
  0001496687
  XXXXXXXX
  LIVE
  0001492422
  Apellis Pharmaceuticals, Inc.
  001-38276
  100 FIFTH AVENUE
  WALTHAM
  MA
  02451
  617-977-5700
  Machiels Alec
  Director
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  1250
  60625.00
  117737289
  10/17/2023
  NASDAQ
  Common
  10/17/2023
  Option Granted 12/05/2013
  Issuer
  N
  1250
  10/17/2023
  Cash
  N
  Alec Machiels
  100 Fifth Avenue
  Waltham
  MA
  02451
  Common
  09/18/2023
  1250
  56250.00
  Alec Machiels
  100 Fifth Avenue
  Waltham
  MA
  02451
  Common
  09/15/2023
  1250
  56675.00
  Alec Machiels
  100 Fifth Avenue
  Waltham
  MA
  02451
  Common
  07/17/2023
  1250
  80987.50
  10/17/2023
  12/16/2022
  /s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Alec Machiels