content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001725189</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
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      <issuerInfo>
        <issuerCik>0001704292</issuerCik>
        <issuerName>Zai Lab Ltd</issuerName>
        <secFileNumber>001-38205</secFileNumber>
        <issuerAddress>
          <com:street1>4560 JINKE ROAD</com:street1>
          <com:street2>BLDG. 1, 4F, PUDONG</com:street2>
          <com:city>SHANGHAI</com:city>
          <com:stateOrCountry>F4</com:stateOrCountry>
          <com:zipCode>201210</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>862161632588</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Smiley Joshua L</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3354</noOfUnitsSold>
        <aggregateMarketValue>111045.91</aggregateMarketValue>
        <noOfUnitsOutstanding>847651100</noOfUnitsOutstanding>
        <approxSaleDate>04/04/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <acquiredDate>04/03/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3354</amountOfSecuritiesAcquired>
        <paymentDate>04/03/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Joshua L. Smiley</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, 4th Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>04/02/2025</saleDate>
        <amountOfSecuritiesSold>11740</amountOfSecuritiesSold>
        <grossProceeds>421397.91</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>04/04/2025</noticeDate>
        <signature>/s/ Bradley Camilo, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Joshua L. Smiley</signature>
      </noticeSignature>
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text: 144
  0001725189
  XXXXXXXX
  LIVE
  0001704292
  Zai Lab Ltd
  001-38205
  4560 JINKE ROAD
  BLDG. 1, 4F, PUDONG
  SHANGHAI
  F4
  201210
  862161632588
  Smiley Joshua L
  Officer
  American Depositary Shares
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  3354
  111045.91
  847651100
  04/04/2025
  NASDAQ
  American Depositary Shares
  04/03/2025
  Restricted Stock Vesting
  Issuer
  N
  3354
  04/03/2025
  Compensation
  N
  Joshua L. Smiley
  4560 Jinke Road
  Bldg. 1, 4th Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  04/02/2025
  11740
  421397.91
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  04/04/2025
  /s/ Bradley Camilo, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Joshua L. Smiley