content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001499743</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000354950</issuerCik>
        <issuerName>HOME DEPOT, INC.</issuerName>
        <secFileNumber>001-08207</secFileNumber>
        <issuerAddress>
          <com:street1>2455 PACES FERRY ROAD</com:street1>
          <com:city>ATLANTA</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30339-4024</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>770-433-8211</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Carey Matt</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 summer street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>5769</noOfUnitsSold>
        <aggregateMarketValue>1979286.21</aggregateMarketValue>
        <noOfUnitsOutstanding>991030000</noOfUnitsOutstanding>
        <approxSaleDate>05/16/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/27/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>The Home Depot Inc</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>961</amountOfSecuritiesAcquired>
        <paymentDate>03/27/2024</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/22/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>The Home Depot Inc</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4080</amountOfSecuritiesAcquired>
        <paymentDate>02/22/2024</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Matthew Carey</name>
          <address>
            <com:street1>2455 Paces Ferry Road</com:street1>
            <com:city>Atlanta</com:city>
            <com:stateOrCountry>GA</com:stateOrCountry>
            <com:zipCode>30339</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>The Home Depot INc</securitiesClassTitle>
        <saleDate>05/16/2024</saleDate>
        <amountOfSecuritiesSold>50239</amountOfSecuritiesSold>
        <grossProceeds>17000000.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/16/2024</noticeDate>
        <signature>/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Matthew Carey</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3942}]
text: 144
  0001499743
  XXXXXXXX
  LIVE
  0000354950
  HOME DEPOT, INC.
  001-08207
  2455 PACES FERRY ROAD
  ATLANTA
  GA
  30339-4024
  770-433-8211
  Carey Matt
  Officer
  Common
  Fidelity Brokerage Services LLC
  245 summer street
  Boston
  MA
  02110
  5769
  1979286.21
  991030000
  05/16/2024
  NYSE
  Common
  03/27/2024
  Stock award
  The Home Depot Inc
  N
  961
  03/27/2024
  N/A
  Common
  02/22/2024
  Stock award
  The Home Depot Inc
  N
  4080
  02/22/2024
  N/A
  N
  Matthew Carey
  2455 Paces Ferry Road
  Atlanta
  GA
  30339
  The Home Depot INc
  05/16/2024
  50239
  17000000.00
  05/16/2024
  /s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Matthew Carey