content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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        <filer>
          <filerCredentials>
            <cik>0001787013</cik>
            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001773427</issuerCik>
        <issuerName>SpringWorks Therapeutics, Inc.</issuerName>
        <secFileNumber>001-39044</secFileNumber>
        <issuerAddress>
          <com:street1>100 Washington Blvd</com:street1>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>2038839490</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Lesley Mary Smith</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>10000</noOfUnitsSold>
        <aggregateMarketValue>510100</aggregateMarketValue>
        <noOfUnitsOutstanding>62578877</noOfUnitsOutstanding>
        <approxSaleDate>03/01/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/30/2018</acquiredDate>
        <natureOfAcquisitionTransaction>RSA Vest</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
        <paymentDate>01/30/2018</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>03/01/2024</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Lesley Mary Smith</signature>
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text: 144
  0001787013
  XXXXXXXX
  LIVE
  0001773427
  SpringWorks Therapeutics, Inc.
  001-39044
  100 Washington Blvd
  Stamford
  CT
  06902
  2038839490
  Lesley Mary Smith
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  10000
  510100
  62578877
  03/01/2024
  Nasdaq
  Common
  01/30/2018
  RSA Vest
  Issuer
  N
  10000
  01/30/2018
  Cash
  Y
  03/01/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Lesley Mary Smith