content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001970876</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001070081</issuerCik>
        <issuerName>PTC THERAPEUTICS, INC.</issuerName>
        <secFileNumber>001-35969</secFileNumber>
        <issuerAddress>
          <com:street1>500 WARREN CORPORATE CENTER DRIVE</com:street1>
          <com:city>WARREN</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>9082227000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Almstead Zheng Yang</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Member of immediate family of any of the foregoing</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>107</noOfUnitsSold>
        <aggregateMarketValue>4761.49</aggregateMarketValue>
        <noOfUnitsOutstanding>77125143</noOfUnitsOutstanding>
        <approxSaleDate>01/08/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/06/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>47</amountOfSecuritiesAcquired>
        <paymentDate>01/06/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/07/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>60</amountOfSecuritiesAcquired>
        <paymentDate>01/07/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Neil Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/02/2024</saleDate>
        <amountOfSecuritiesSold>69550</amountOfSecuritiesSold>
        <grossProceeds>3620607.20</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Zheng Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/02/2024</saleDate>
        <amountOfSecuritiesSold>2060</amountOfSecuritiesSold>
        <grossProceeds>107069.94</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Neil Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/07/2025</saleDate>
        <amountOfSecuritiesSold>1265</amountOfSecuritiesSold>
        <grossProceeds>57351.94</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Zheng Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/07/2025</saleDate>
        <amountOfSecuritiesSold>55</amountOfSecuritiesSold>
        <grossProceeds>2493.56</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Zheng Almstead is the spouse of Neil Almstead. Two sales in the past 90 days took place in Neil Almstead's account. Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>01/08/2025</noticeDate>
        <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Zheng Yang Almstead </signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001970876
  XXXXXXXX
  LIVE
  0001070081
  PTC THERAPEUTICS, INC.
  001-35969
  500 WARREN CORPORATE CENTER DRIVE
  WARREN
  NJ
  07059
  9082227000
  Almstead Zheng Yang
  Member of immediate family of any of the foregoing
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  107
  4761.49
  77125143
  01/08/2025
  NASDAQ
  Common
  01/06/2025
  Restricted Stock Vesting
  Issuer
  N
  47
  01/06/2025
  Compensation
  Common
  01/07/2025
  Restricted Stock Vesting
  Issuer
  N
  60
  01/07/2025
  Compensation
  N
  Neil Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  12/02/2024
  69550
  3620607.20
  Zheng Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  12/02/2024
  2060
  107069.94
  Neil Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  01/07/2025
  1265
  57351.94
  Zheng Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  01/07/2025
  55
  2493.56
  Zheng Almstead is the spouse of Neil Almstead. Two sales in the past 90 days took place in Neil Almstead's account. Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  01/08/2025
  /s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Zheng Yang Almstead