content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001871335</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001805651</issuerCik>
        <issuerName>MARKETWISE, INC.</issuerName>
        <secFileNumber>001-39405</secFileNumber>
        <issuerAddress>
          <com:street1>667 MADISON AVENUE</com:street1>
          <com:street2>5TH FLOOR</com:street2>
          <com:city>NEW YORK</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10065</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(212) 209-6126</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Stansberry Frank Porter</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Morgan Stanley Smith Barney</name>
          <address>
            <com:street1>1 New York Plaza</com:street1>
            <com:street2>38th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10004</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>250000</noOfUnitsSold>
        <aggregateMarketValue>500000.00</aggregateMarketValue>
        <noOfUnitsOutstanding>35429642</noOfUnitsOutstanding>
        <approxSaleDate>06/28/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/21/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Redemption of Common Units</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>250000</amountOfSecuritiesAcquired>
        <paymentDate>07/21/2021</paymentDate>
        <natureOfPayment>See Remarks</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>On July 21, 2021, the Reporting Person received 64,814,214 Common Units of MarketWise, LLC, as a result of the recapitalization of MarketWise, LLC in connection with the completion of a series of transactions by which the Issuer became a public reporting company, as described in the Issuer's prospectus filed with the Securities and Exchange Commission on July 1, 2021.  The Common Units of MarketWise, LLC are exchangeable for shares of Class A Common Stock of the Issuer on a one-for-one basis at the option of the holder. The Reporting Person redeemed 250,000 Common Units for Class A Common Shares of the Issuer on June 23, 2023.</remarks>
      <noticeSignature>
        <noticeDate>06/28/2023</noticeDate>
        <signature>/s/ Frank Porter Stansberry</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3494}]
text: 144
  0001871335
  XXXXXXXX
  LIVE
  0001805651
  MARKETWISE, INC.
  001-39405
  667 MADISON AVENUE
  5TH FLOOR
  NEW YORK
  NY
  10065
  (212) 209-6126
  Stansberry Frank Porter
  10% Stockholder
  Common
  Morgan Stanley Smith Barney
  1 New York Plaza
  38th Floor
  New York
  NY
  10004
  250000
  500000.00
  35429642
  06/28/2023
  NASDAQ
  Common
  07/21/2021
  Redemption of Common Units
  Issuer
  N
  250000
  07/21/2021
  See Remarks
  Y
  On July 21, 2021, the Reporting Person received 64,814,214 Common Units of MarketWise, LLC, as a result of the recapitalization of MarketWise, LLC in connection with the completion of a series of transactions by which the Issuer became a public reporting company, as described in the Issuer's prospectus filed with the Securities and Exchange Commission on July 1, 2021.  The Common Units of MarketWise, LLC are exchangeable for shares of Class A Common Stock of the Issuer on a one-for-one basis at the option of the holder. The Reporting Person redeemed 250,000 Common Units for Class A Common Shares of the Issuer on June 23, 2023.
  06/28/2023
  /s/ Frank Porter Stansberry