content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001801395</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001521036</issuerCik>
        <issuerName>Lantheus Holdings, Inc.</issuerName>
        <secFileNumber>001-36569</secFileNumber>
        <issuerAddress>
          <com:street1>331 TREBLE COVE ROAD</com:street1>
          <com:city>NORTH BILLERICA</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>01862</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>978 671-8001</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Blanchfield Paul</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1500</noOfUnitsSold>
        <aggregateMarketValue>101940.00</aggregateMarketValue>
        <noOfUnitsOutstanding>68489153</noOfUnitsOutstanding>
        <approxSaleDate>11/16/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/03/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1500</amountOfSecuritiesAcquired>
        <paymentDate>03/03/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>PAUL BLANCHFIELD</name>
          <address>
            <com:street1>201 Burlington Road</com:street1>
            <com:street2>South Building</com:street2>
            <com:city>Bedford</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>01730</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>08/18/2023</saleDate>
        <amountOfSecuritiesSold>1500</amountOfSecuritiesSold>
        <grossProceeds>97785.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>PAUL BLANCHFIELD</name>
          <address>
            <com:street1>201 Burlington Road</com:street1>
            <com:street2>South Building</com:street2>
            <com:city>Bedford</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>01730</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>08/21/2023</saleDate>
        <amountOfSecuritiesSold>408</amountOfSecuritiesSold>
        <grossProceeds>26968.80</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/16/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>05/22/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Paul Blanchfield</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001801395
  XXXXXXXX
  LIVE
  0001521036
  Lantheus Holdings, Inc.
  001-36569
  331 TREBLE COVE ROAD
  NORTH BILLERICA
  MA
  01862
  978 671-8001
  Blanchfield Paul
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  1500
  101940.00
  68489153
  11/16/2023
  NASDAQ
  Common
  03/03/2022
  Restricted Stock Vesting
  Issuer
  N
  1500
  03/03/2022
  Compensation
  N
  PAUL BLANCHFIELD
  201 Burlington Road
  South Building
  Bedford
  MA
  01730
  Common
  08/18/2023
  1500
  97785.00
  PAUL BLANCHFIELD
  201 Burlington Road
  South Building
  Bedford
  MA
  01730
  Common
  08/21/2023
  408
  26968.80
  11/16/2023
  05/22/2023
  /s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Paul Blanchfield