content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001746251</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
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      <issuerInfo>
        <issuerCik>0001267565</issuerCik>
        <issuerName>COLLEGIUM PHARMACEUTICAL, INC</issuerName>
        <secFileNumber>001-37372</secFileNumber>
        <issuerAddress>
          <com:street1>100 TECHNOLOGY CENTER DRIVE</com:street1>
          <com:city>STOUGHTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02072</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>781-713-3699</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Dreyer Scott</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3295</noOfUnitsSold>
        <aggregateMarketValue>98853.50</aggregateMarketValue>
        <noOfUnitsOutstanding>31485523</noOfUnitsOutstanding>
        <approxSaleDate>03/06/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/10/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3295</amountOfSecuritiesAcquired>
        <paymentDate>02/10/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>03/06/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>08/28/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Scott Dreyer </signature>
      </noticeSignature>
    </formData>
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text: 144
  0001746251
  XXXXXXXX
  LIVE
  0001267565
  COLLEGIUM PHARMACEUTICAL, INC
  001-37372
  100 TECHNOLOGY CENTER DRIVE
  STOUGHTON
  MA
  02072
  781-713-3699
  Dreyer Scott
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  3295
  98853.50
  31485523
  03/06/2025
  NASDAQ
  Common
  02/10/2025
  Restricted Stock Vesting
  Issuer
  N
  3295
  02/10/2025
  Compensation
  Y
  03/06/2025
  08/28/2024
  /s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Scott Dreyer