content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001970876</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001070081</issuerCik>
        <issuerName>PTC THERAPEUTICS, INC.</issuerName>
        <secFileNumber>001-35969</secFileNumber>
        <issuerAddress>
          <com:street1>500 WARREN CORPORATE CENTER DRIVE</com:street1>
          <com:city>WARREN</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>9082227000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Almstead Zheng Yang</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Member of immediate family of any of the foregoing</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>2060</noOfUnitsSold>
        <aggregateMarketValue>107069.90</aggregateMarketValue>
        <noOfUnitsOutstanding>77125143</noOfUnitsOutstanding>
        <approxSaleDate>12/02/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/02/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted - 01/02/2015</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2060</amountOfSecuritiesAcquired>
        <paymentDate>12/02/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Today's sale occurred in the account of Zheng Y. Almstead, who is the spouse of Neil G Almstead, an officer of the company.</remarks>
      <noticeSignature>
        <noticeDate>12/02/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>02/24/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Zheng Y. Almstead</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3145}]
text: 144
  0001970876
  XXXXXXXX
  LIVE
  0001070081
  PTC THERAPEUTICS, INC.
  001-35969
  500 WARREN CORPORATE CENTER DRIVE
  WARREN
  NJ
  07059
  9082227000
  Almstead Zheng Yang
  Member of immediate family of any of the foregoing
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  2060
  107069.90
  77125143
  12/02/2024
  NASDAQ
  Common
  12/02/2024
  Option Granted - 01/02/2015
  Issuer
  N
  2060
  12/02/2024
  Cash
  Y
  Today's sale occurred in the account of Zheng Y. Almstead, who is the spouse of Neil G Almstead, an officer of the company.
  12/02/2024
  02/24/2023
  /s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Zheng Y. Almstead