content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001860609</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001737953</issuerCik>
        <issuerName>Replimune Group Inc.</issuerName>
        <secFileNumber>001-38596</secFileNumber>
        <issuerAddress>
          <com:street1>500 Unicorn Park Drive</com:street1>
          <com:street2>Suite 303</com:street2>
          <com:city>Woburn</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>01801</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>7812229600</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sushil Patel</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>23710</noOfUnitsSold>
        <aggregateMarketValue>555999</aggregateMarketValue>
        <noOfUnitsOutstanding>57775993</noOfUnitsOutstanding>
        <approxSaleDate>06/13/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>11396</amountOfSecuritiesAcquired>
        <paymentDate>05/15/2022</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/15/2023</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>12314</amountOfSecuritiesAcquired>
        <paymentDate>05/15/2023</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>06/13/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/15/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Sushil Patel</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001860609
  XXXXXXXX
  LIVE
  0001737953
  Replimune Group Inc.
  001-38596
  500 Unicorn Park Drive
  Suite 303
  Woburn
  MA
  01801
  7812229600
  Sushil Patel
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  23710
  555999
  57775993
  06/13/2023
  Nasdaq
  Common
  05/15/2022
  RSU Vesting
  Issuer
  N
  11396
  05/15/2022
  NA
  Common
  05/15/2023
  RSU Vesting
  Issuer
  N
  12314
  05/15/2023
  NA
  Y
  06/13/2023
  03/15/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Sushil Patel