content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001671311</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001724521</issuerCik>
        <issuerName>Arcus Biosciences, Inc.</issuerName>
        <secFileNumber>001-38419</secFileNumber>
        <issuerAddress>
          <com:street1>3928 Point Eden Way</com:street1>
          <com:city>Hayward</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94545</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>510-694-6200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jennifer Jarrett</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>56551</noOfUnitsSold>
        <aggregateMarketValue>955712</aggregateMarketValue>
        <noOfUnitsOutstanding>90864829</noOfUnitsOutstanding>
        <approxSaleDate>03/27/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/15/2024</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>11551</amountOfSecuritiesAcquired>
        <paymentDate>03/15/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>01/26/2018</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>22500</amountOfSecuritiesAcquired>
        <paymentDate>01/26/2018</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/27/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>22500</amountOfSecuritiesAcquired>
        <paymentDate>03/27/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Jennifer Jarrett</name>
          <address>
            <com:street1>C/o Arcus Biosciences, Inc.</com:street1>
            <com:street2>3928 Point Eden Way</com:street2>
            <com:city>Hayward</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94545</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>02/26/2024</saleDate>
        <amountOfSecuritiesSold>24555</amountOfSecuritiesSold>
        <grossProceeds>492887</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Jennifer Jarrett</name>
          <address>
            <com:street1>C/o Arcus Biosciences, Inc.</com:street1>
            <com:street2>3928 Point Eden Way</com:street2>
            <com:city>Hayward</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94545</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>02/27/2024</saleDate>
        <amountOfSecuritiesSold>34070</amountOfSecuritiesSold>
        <grossProceeds>685215</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Some of the shares covered by this filing are stock options that will be exercised within 3 months from the date of this filing.</remarks>
      <noticeSignature>
        <noticeDate>03/27/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>02/22/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jennifer Jarrett</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5495}]
text: 144
  0001671311
  XXXXXXXX
  LIVE
  0001724521
  Arcus Biosciences, Inc.
  001-38419
  3928 Point Eden Way
  Hayward
  CA
  94545
  510-694-6200
  Jennifer Jarrett
  Officer
  Common Stock
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  56551
  955712
  90864829
  03/27/2024
  NYSE
  Common Stock
  03/15/2024
  RSU Vesting
  Issuer
  N
  11551
  03/15/2024
  Compensation
  Common Stock
  01/26/2018
  Stock Option Exercise
  Issuer
  N
  22500
  01/26/2018
  Cash
  Common Stock
  03/27/2024
  Stock Option Exercise
  Issuer
  N
  22500
  03/27/2024
  Cash
  N
  Jennifer Jarrett
  C/o Arcus Biosciences, Inc.
  3928 Point Eden Way
  Hayward
  CA
  94545
  Common Stock
  02/26/2024
  24555
  492887
  Jennifer Jarrett
  C/o Arcus Biosciences, Inc.
  3928 Point Eden Way
  Hayward
  CA
  94545
  Common Stock
  02/27/2024
  34070
  685215
  Some of the shares covered by this filing are stock options that will be exercised within 3 months from the date of this filing.
  03/27/2024
  02/22/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jennifer Jarrett