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        <issuerAddress>
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          <com:street2>Suite 1430</com:street2>
          <com:city>Dallas</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75247</com:zipCode>
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        <issuerContactPhone>212-612-0000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>R.A. Sessions II</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
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            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
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        <noOfUnitsOutstanding>64178567</noOfUnitsOutstanding>
        <approxSaleDate>06/20/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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        <natureOfAcquisitionTransaction>Founder Shares</natureOfAcquisitionTransaction>
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        <noticeDate>06/20/2023</noticeDate>
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text: 144
  0001701846
  XXXXXXXX
  LIVE
  0001806310
  Taysha Gene Therapies Inc
  001-39536
  3000 Pegasus Park Drive
  Suite 1430
  Dallas
  TX
  75247
  212-612-0000
  R.A. Sessions II
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  1006000
  699572.4
  64178567
  06/20/2023
  Nasdaq
  Common
  09/23/2020
  Founder Shares
  Issuer
  N
  1006000
  09/23/2020
  N/A
  Y
  06/20/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for R.A. Sessions II