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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001578850</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001070081</issuerCik>
        <issuerName>PTC THERAPEUTICS, INC.</issuerName>
        <secFileNumber>001-35969</secFileNumber>
        <issuerAddress>
          <com:street1>500 WARREN CORPORATE CENTER DRIVE</com:street1>
          <com:city>WARREN</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>9082227000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Almstead Neil Gregory</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Member of immediate family of any of the foregoing</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>34</noOfUnitsSold>
        <aggregateMarketValue>1704.22</aggregateMarketValue>
        <noOfUnitsOutstanding>77125143</noOfUnitsOutstanding>
        <approxSaleDate>02/20/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/19/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>34</amountOfSecuritiesAcquired>
        <paymentDate>02/19/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Neil G. Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/02/2024</saleDate>
        <amountOfSecuritiesSold>69550</amountOfSecuritiesSold>
        <grossProceeds>3620607.20</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Zheng Yang Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/02/2024</saleDate>
        <amountOfSecuritiesSold>2060</amountOfSecuritiesSold>
        <grossProceeds>107069.94</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Neil G. Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/07/2025</saleDate>
        <amountOfSecuritiesSold>1265</amountOfSecuritiesSold>
        <grossProceeds>57351.94</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Zheng Yang Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/07/2025</saleDate>
        <amountOfSecuritiesSold>55</amountOfSecuritiesSold>
        <grossProceeds>2493.56</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Neil G. Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/08/2025</saleDate>
        <amountOfSecuritiesSold>1552</amountOfSecuritiesSold>
        <grossProceeds>69063.85</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Zheng Yang Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/08/2025</saleDate>
        <amountOfSecuritiesSold>107</amountOfSecuritiesSold>
        <grossProceeds>4761.49</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Neil G. Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/19/2025</saleDate>
        <amountOfSecuritiesSold>1300</amountOfSecuritiesSold>
        <grossProceeds>65125.32</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Zheng Yang Almstead</name>
          <address>
            <com:street1>500 Warren Corporate Center Drive</com:street1>
            <com:city>Warren</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07059</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/19/2025</saleDate>
        <amountOfSecuritiesSold>34</amountOfSecuritiesSold>
        <grossProceeds>1703.28</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution. Today's sale as well as sales on 12/02/2024, 01/07/2025, 01/08/2025 and 02/19/2025 occurred in the account of Zheng Yang Almstead, who is the spouse of Neil G. Almstead, an officer of the company.</remarks>
      <noticeSignature>
        <noticeDate>02/20/2025</noticeDate>
        <signature>/s/ Tyler Johnson, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Zheng Y. Almstead</signature>
      </noticeSignature>
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text: 144
  0001578850
  XXXXXXXX
  LIVE
  0001070081
  PTC THERAPEUTICS, INC.
  001-35969
  500 WARREN CORPORATE CENTER DRIVE
  WARREN
  NJ
  07059
  9082227000
  Almstead Neil Gregory
  Member of immediate family of any of the foregoing
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  34
  1704.22
  77125143
  02/20/2025
  NASDAQ
  Common
  02/19/2025
  Restricted Stock Vesting
  Issuer
  N
  34
  02/19/2025
  Compensation
  N
  Neil G. Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  12/02/2024
  69550
  3620607.20
  Zheng Yang Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  12/02/2024
  2060
  107069.94
  Neil G. Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  01/07/2025
  1265
  57351.94
  Zheng Yang Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  01/07/2025
  55
  2493.56
  Neil G. Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  01/08/2025
  1552
  69063.85
  Zheng Yang Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  01/08/2025
  107
  4761.49
  Neil G. Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  02/19/2025
  1300
  65125.32
  Zheng Yang Almstead
  500 Warren Corporate Center Drive
  Warren
  NJ
  07059
  Common
  02/19/2025
  34
  1703.28
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution. Today's sale as well as sales on 12/02/2024, 01/07/2025, 01/08/2025 and 02/19/2025 occurred in the account of Zheng Yang Almstead, who is the spouse of Neil G. Almstead, an officer of the company.
  02/20/2025
  /s/ Tyler Johnson, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Zheng Y. Almstead