content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001402222</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001814114</issuerCik>
        <issuerName>Orchestra BioMed Holdings, Inc.</issuerName>
        <secFileNumber>001-39421</secFileNumber>
        <issuerAddress>
          <com:street1>150 UNION SQUARE DRIVE</com:street1>
          <com:city>NEW HOPE</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>18938</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>646-343-9298</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Fain Eric S</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1800</noOfUnitsSold>
        <aggregateMarketValue>9620.29</aggregateMarketValue>
        <noOfUnitsOutstanding>37824571</noOfUnitsOutstanding>
        <approxSaleDate>09/10/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/18/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1800</amountOfSecuritiesAcquired>
        <paymentDate>08/18/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Fain Living Trust</name>
          <address>
            <com:street1>150 Union Square Drive</com:street1>
            <com:city>New Hope</com:city>
            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>18938</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/06/2024</saleDate>
        <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
        <grossProceeds>11279.11</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Fain Living Trust</name>
          <address>
            <com:street1>150 Union Square Drive</com:street1>
            <com:city>New Hope</com:city>
            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>18938</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/09/2024</saleDate>
        <amountOfSecuritiesSold>1800</amountOfSecuritiesSold>
        <grossProceeds>9773.66</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>The sale today and the securities sold during the past 3 months took place in the Fain Living Trust account in which Eric Fain is a trustee.</remarks>
      <noticeSignature>
        <noticeDate>09/10/2024</noticeDate>
        <signature>/s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Eric S. Fain</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001402222
  XXXXXXXX
  LIVE
  0001814114
  Orchestra BioMed Holdings, Inc.
  001-39421
  150 UNION SQUARE DRIVE
  NEW HOPE
  PA
  18938
  646-343-9298
  Fain Eric S
  Director
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  1800
  9620.29
  37824571
  09/10/2024
  NASDAQ
  Common
  08/18/2024
  Restricted Stock Vesting
  Issuer
  N
  1800
  08/18/2024
  Compensation
  N
  Fain Living Trust
  150 Union Square Drive
  New Hope
  PA
  18938
  Common
  09/06/2024
  2000
  11279.11
  Fain Living Trust
  150 Union Square Drive
  New Hope
  PA
  18938
  Common
  09/09/2024
  1800
  9773.66
  The sale today and the securities sold during the past 3 months took place in the Fain Living Trust account in which Eric Fain is a trustee.
  09/10/2024
  /s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Eric S. Fain