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        <issuerAddress>
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          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>800-719-0671</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Green Paula</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
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      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>322</noOfUnitsSold>
        <aggregateMarketValue>15456.74</aggregateMarketValue>
        <noOfUnitsOutstanding>58225999</noOfUnitsOutstanding>
        <approxSaleDate>07/02/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <acquiredDate>07/01/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>322</amountOfSecuritiesAcquired>
        <paymentDate>07/01/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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          <name>Paula Green</name>
          <address>
            <com:street1>681 Gateway Blvd</com:street1>
            <com:city>South San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
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        <securitiesClassTitle>Common</securitiesClassTitle>
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        <amountOfSecuritiesSold>229</amountOfSecuritiesSold>
        <grossProceeds>7496.62</grossProceeds>
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      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Paula Green</name>
          <address>
            <com:street1>681 Gateway Blvd</com:street1>
            <com:city>South San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>05/03/2024</saleDate>
        <amountOfSecuritiesSold>910</amountOfSecuritiesSold>
        <grossProceeds>33791.58</grossProceeds>
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        <sellerDetails>
          <name>Paula Green</name>
          <address>
            <com:street1>681 Gateway Blvd</com:street1>
            <com:city>South San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
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        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>06/06/2024</saleDate>
        <amountOfSecuritiesSold>918</amountOfSecuritiesSold>
        <grossProceeds>47119.65</grossProceeds>
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        <sellerDetails>
          <name>Paula Green</name>
          <address>
            <com:street1>681 Gateway Blvd</com:street1>
            <com:city>South San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>06/20/2024</saleDate>
        <amountOfSecuritiesSold>297</amountOfSecuritiesSold>
        <grossProceeds>14674.62</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>07/02/2024</noticeDate>
        <signature>/S/ Adam Gehring, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Paula Green</signature>
      </noticeSignature>
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text: 144
  0001753672
  XXXXXXXX
  LIVE
  0001581280
  Twist Bioscience Corp
  001-38720
  681 GATEWAY BLVD.
  SOUTH SAN FRANCISCO
  CA
  94080
  800-719-0671
  Green Paula
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  322
  15456.74
  58225999
  07/02/2024
  NASDAQ
  Common
  07/01/2024
  Restricted Stock Vesting
  Issuer
  N
  322
  07/01/2024
  Compensation
  N
  Paula Green
  681 Gateway Blvd
  South San Francisco
  CA
  94080
  Common
  04/02/2024
  229
  7496.62
  Paula Green
  681 Gateway Blvd
  South San Francisco
  CA
  94080
  Common
  05/03/2024
  910
  33791.58
  Paula Green
  681 Gateway Blvd
  South San Francisco
  CA
  94080
  Common
  06/06/2024
  918
  47119.65
  Paula Green
  681 Gateway Blvd
  South San Francisco
  CA
  94080
  Common
  06/20/2024
  297
  14674.62
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  07/02/2024
  /S/ Adam Gehring, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Paula Green