content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001705850</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001192448</issuerCik>
        <issuerName>GLAUKOS Corp</issuerName>
        <secFileNumber>001-37463</secFileNumber>
        <issuerAddress>
          <com:street1>229 AVENIDA FABRICANTE</com:street1>
          <com:city>SAN CLEMENTE</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92672</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>949-367-9600</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Gilliam Joseph E</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>631</noOfUnitsSold>
        <aggregateMarketValue>61016.57</aggregateMarketValue>
        <noOfUnitsOutstanding>48799581</noOfUnitsOutstanding>
        <approxSaleDate>02/09/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/09/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted 03/24/2022</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>631</amountOfSecuritiesAcquired>
        <paymentDate>02/09/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Joseph Gilliam</name>
          <address>
            <com:street1>One Glaukos Way</com:street1>
            <com:city>Aliso Viejo</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>92656</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/21/2023</saleDate>
        <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
        <grossProceeds>4239965.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Joseph Gilliam</name>
          <address>
            <com:street1>One Glaukos Way</com:street1>
            <com:city>Aliso Viejo</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>92656</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/12/2024</saleDate>
        <amountOfSecuritiesSold>221</amountOfSecuritiesSold>
        <grossProceeds>19671.21</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Joseph Gilliam</name>
          <address>
            <com:street1>One Glaukos Way</com:street1>
            <com:city>Aliso Viejo</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>92656</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/16/2024</saleDate>
        <amountOfSecuritiesSold>9779</amountOfSecuritiesSold>
        <grossProceeds>872033.52</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Joseph Gilliam</name>
          <address>
            <com:street1>One Glaukos Way</com:street1>
            <com:city>Aliso Viejo</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>92656</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/22/2024</saleDate>
        <amountOfSecuritiesSold>524</amountOfSecuritiesSold>
        <grossProceeds>49262.24</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Joseph Gilliam</name>
          <address>
            <com:street1>One Glaukos Way</com:street1>
            <com:city>Aliso Viejo</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>92656</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/29/2024</saleDate>
        <amountOfSecuritiesSold>9476</amountOfSecuritiesSold>
        <grossProceeds>891835.64</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Joseph Gilliam</name>
          <address>
            <com:street1>One Glaukos Way</com:street1>
            <com:city>Aliso Viejo</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>92656</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/08/2024</saleDate>
        <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
        <grossProceeds>480357.50</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>02/09/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/07/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/S/ Adam Gehring, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Joseph Gilliam</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6425}]
text: 144
  0001705850
  XXXXXXXX
  LIVE
  0001192448
  GLAUKOS Corp
  001-37463
  229 AVENIDA FABRICANTE
  SAN CLEMENTE
  CA
  92672
  949-367-9600
  Gilliam Joseph E
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  631
  61016.57
  48799581
  02/09/2024
  NYSE
  Common
  02/09/2024
  Option Granted 03/24/2022
  Issuer
  N
  631
  02/09/2024
  Cash
  N
  Joseph Gilliam
  One Glaukos Way
  Aliso Viejo
  CA
  92656
  Common
  12/21/2023
  50000
  4239965.00
  Joseph Gilliam
  One Glaukos Way
  Aliso Viejo
  CA
  92656
  Common
  01/12/2024
  221
  19671.21
  Joseph Gilliam
  One Glaukos Way
  Aliso Viejo
  CA
  92656
  Common
  01/16/2024
  9779
  872033.52
  Joseph Gilliam
  One Glaukos Way
  Aliso Viejo
  CA
  92656
  Common
  01/22/2024
  524
  49262.24
  Joseph Gilliam
  One Glaukos Way
  Aliso Viejo
  CA
  92656
  Common
  01/29/2024
  9476
  891835.64
  Joseph Gilliam
  One Glaukos Way
  Aliso Viejo
  CA
  92656
  Common
  02/08/2024
  5000
  480357.50
  02/09/2024
  03/07/2023
  /S/ Adam Gehring, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Joseph Gilliam