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      <submissionType>144</submissionType>
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        <filer>
          <filerCredentials>
            <cik>0001848136</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001645590</issuerCik>
        <issuerName>Hewlett Packard Enterprise Co</issuerName>
        <secFileNumber>001-37483</secFileNumber>
        <issuerAddress>
          <com:street1>1701 E MOSSY OAKS ROAD</com:street1>
          <com:city>SPRING</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77389</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>678-259-9860</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Hotard Justin</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Merrill Lynch</name>
          <address>
            <com:street1>3455 Peachtree Road NE</com:street1>
            <com:street2>Suite 1000</com:street2>
            <com:city>Atlanta</com:city>
            <com:stateOrCountry>GA</com:stateOrCountry>
            <com:zipCode>30326</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>10227</noOfUnitsSold>
        <aggregateMarketValue>173859.00</aggregateMarketValue>
        <noOfUnitsOutstanding>1291518139</noOfUnitsOutstanding>
        <approxSaleDate>06/15/2023</approxSaleDate>
        <securitiesExchangeName>New York</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/15/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Exercise of Stock Option Awards</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Hewlett Packard Enterprise Company</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>10227</amountOfSecuritiesAcquired>
        <paymentDate>06/15/2023</paymentDate>
        <natureOfPayment>Compensatory Payment</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Justin Hotard</name>
          <address>
            <com:street1>1701 E Mossy Oaks Road</com:street1>
            <com:city>Spring</com:city>
            <com:stateOrCountry>TX</com:stateOrCountry>
            <com:zipCode>77389</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/03/2023</saleDate>
        <amountOfSecuritiesSold>14162</amountOfSecuritiesSold>
        <grossProceeds>226592.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>06/15/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/06/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>Justin Hotard</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001848136
  XXXXXXXX
  LIVE
  0001645590
  Hewlett Packard Enterprise Co
  001-37483
  1701 E MOSSY OAKS ROAD
  SPRING
  TX
  77389
  678-259-9860
  Hotard Justin
  Officer
  Common
  Merrill Lynch
  3455 Peachtree Road NE
  Suite 1000
  Atlanta
  GA
  30326
  10227
  173859.00
  1291518139
  06/15/2023
  New York
  Common
  06/15/2023
  Exercise of Stock Option Awards
  Hewlett Packard Enterprise Company
  N
  10227
  06/15/2023
  Compensatory Payment
  N
  Justin Hotard
  1701 E Mossy Oaks Road
  Spring
  TX
  77389
  Common
  04/03/2023
  14162
  226592.00
  06/15/2023
  03/06/2023
  Justin Hotard