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        <filer>
          <filerCredentials>
            <cik>0001635326</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
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      <issuerInfo>
        <issuerCik>0001447028</issuerCik>
        <issuerName>Arbutus Biopharma Corp</issuerName>
        <secFileNumber>001-34949</secFileNumber>
        <issuerAddress>
          <com:street1>701 VETERANS CIRCLE</com:street1>
          <com:city>WARMINSTER</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>18974</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>604-419-3200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>McElhaugh Michael J.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Rockefeller Capital Management</name>
          <address>
            <com:street1>45 Rockefeller Plaza, Floor 5</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10111</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>53114</noOfUnitsSold>
        <aggregateMarketValue>170098.00</aggregateMarketValue>
        <noOfUnitsOutstanding>191480188</noOfUnitsOutstanding>
        <approxSaleDate>04/15/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/26/2015</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ABUS</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>53114</amountOfSecuritiesAcquired>
        <paymentDate>09/26/2015</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>04/15/2025</noticeDate>
        <signature>/s/ Carmen Zamores as a duly authorized representative of National Financial Services LLC, as attorney-in-fact for McElhaugh Michael J</signature>
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text: 144
  0001635326
  XXXXXXXX
  LIVE
  0001447028
  Arbutus Biopharma Corp
  001-34949
  701 VETERANS CIRCLE
  WARMINSTER
  PA
  18974
  604-419-3200
  McElhaugh Michael J.
  Director
  Common
  Rockefeller Capital Management
  45 Rockefeller Plaza, Floor 5
  New York
  NY
  10111
  53114
  170098.00
  191480188
  04/15/2025
  NASDAQ
  Common
  09/26/2015
  Stock Award
  ABUS
  N
  53114
  09/26/2015
  Compensation
  Y
  04/15/2025
  /s/ Carmen Zamores as a duly authorized representative of National Financial Services LLC, as attorney-in-fact for McElhaugh Michael J