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      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001731790</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001704292</issuerCik>
        <issuerName>Zai Lab Ltd</issuerName>
        <secFileNumber>001-38205</secFileNumber>
        <issuerAddress>
          <com:street1>4560 JINKE ROAD</com:street1>
          <com:street2>BLDG. 1, 4F, PUDONG</com:street2>
          <com:city>SHANGHAI</com:city>
          <com:stateOrCountry>F4</com:stateOrCountry>
          <com:zipCode>201210</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>862161632588</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Du Ying</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>6918</noOfUnitsSold>
        <aggregateMarketValue>245723.90</aggregateMarketValue>
        <noOfUnitsOutstanding>486853250</noOfUnitsOutstanding>
        <approxSaleDate>06/30/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <acquiredDate>06/27/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6918</amountOfSecuritiesAcquired>
        <paymentDate>06/27/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, 4th Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>04/02/2025</saleDate>
        <amountOfSecuritiesSold>5808</amountOfSecuritiesSold>
        <grossProceeds>208473.51</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>04/04/2025</saleDate>
        <amountOfSecuritiesSold>2945</amountOfSecuritiesSold>
        <grossProceeds>97504.53</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>05/09/2025</saleDate>
        <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
        <grossProceeds>1481140.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>05/12/2025</saleDate>
        <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
        <grossProceeds>1472165.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>05/13/2025</saleDate>
        <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
        <grossProceeds>1428650.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road, Bldg. 1</com:street1>
            <com:street2>Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>05/14/2025</saleDate>
        <amountOfSecuritiesSold>46389</amountOfSecuritiesSold>
        <grossProceeds>1302858.26</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>06/26/2025</saleDate>
        <amountOfSecuritiesSold>23669</amountOfSecuritiesSold>
        <grossProceeds>855196.47</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>06/30/2025</noticeDate>
        <signature>/s/ Jennifer Ruchti, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Ying Du</signature>
      </noticeSignature>
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text: 144
  0001731790
  XXXXXXXX
  LIVE
  0001704292
  Zai Lab Ltd
  001-38205
  4560 JINKE ROAD
  BLDG. 1, 4F, PUDONG
  SHANGHAI
  F4
  201210
  862161632588
  Du Ying
  Officer
  Director
  American Depositary Shares
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  6918
  245723.90
  486853250
  06/30/2025
  NASDAQ
  American Depositary Shares
  06/27/2025
  Restricted Stock Vesting
  Issuer
  N
  6918
  06/27/2025
  Compensation
  N
  Ying Du
  4560 Jinke Road
  Bldg. 1, 4th Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  04/02/2025
  5808
  208473.51
  Ying Du
  4560 Jinke Road
  Bldg. 1, Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  04/04/2025
  2945
  97504.53
  Ying Du
  4560 Jinke Road
  Bldg. 1, Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  05/09/2025
  50000
  1481140.00
  Ying Du
  4560 Jinke Road
  Bldg. 1, Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  05/12/2025
  50000
  1472165.00
  Ying Du
  4560 Jinke Road
  Bldg. 1, Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  05/13/2025
  50000
  1428650.00
  Ying Du
  4560 Jinke Road, Bldg. 1
  Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  05/14/2025
  46389
  1302858.26
  Ying Du
  4560 Jinke Road
  Bldg. 1, Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  06/26/2025
  23669
  855196.47
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  06/30/2025
  /s/ Jennifer Ruchti, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Ying Du