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        <filer>
          <filerCredentials>
            <cik>0001883986</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
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      <issuerInfo>
        <issuerCik>0001590750</issuerCik>
        <issuerName>Viridian Therapeutics, Inc.\DE</issuerName>
        <secFileNumber>001-36483</secFileNumber>
        <issuerAddress>
          <com:street1>221 CRESCENT STREET</com:street1>
          <com:street2>BLDG. 17, SUITE 401</com:street2>
          <com:city>WALTHAM</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02453</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617.272.4600</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Meisner Lara</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3125</noOfUnitsSold>
        <aggregateMarketValue>53031.25</aggregateMarketValue>
        <noOfUnitsOutstanding>52586039</noOfUnitsOutstanding>
        <approxSaleDate>12/01/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/01/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted 09/22/2021</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3125</amountOfSecuritiesAcquired>
        <paymentDate>12/01/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/01/2023</noticeDate>
        <signature>/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Lara Meisner</signature>
      </noticeSignature>
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text: 144
  0001883986
  XXXXXXXX
  LIVE
  0001590750
  Viridian Therapeutics, Inc.\DE
  001-36483
  221 CRESCENT STREET
  BLDG. 17, SUITE 401
  WALTHAM
  MA
  02453
  617.272.4600
  Meisner Lara
  Former Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  3125
  53031.25
  52586039
  12/01/2023
  NASDAQ
  Common
  12/01/2023
  Option Granted 09/22/2021
  Issuer
  N
  3125
  12/01/2023
  Cash
  Y
  12/01/2023
  /s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Lara Meisner