content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001120477</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
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      <issuerInfo>
        <issuerCik>0001377121</issuerCik>
        <issuerName>Protagonist Therapeutics, Inc.</issuerName>
        <secFileNumber>001-37852</secFileNumber>
        <issuerAddress>
          <com:street1>7707 Gateway Boulevard, Suite 140</com:street1>
          <com:city>Newark</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94560</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>5104740170</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Dinesh Patel</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>CEO</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Commom</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>35000</noOfUnitsSold>
        <aggregateMarketValue>1180200</aggregateMarketValue>
        <noOfUnitsOutstanding>58652133</noOfUnitsOutstanding>
        <approxSaleDate>06/07/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/10/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>10940</amountOfSecuritiesAcquired>
        <paymentDate>03/10/2017</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/06/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>20000</amountOfSecuritiesAcquired>
        <paymentDate>04/06/2017</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/04/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4060</amountOfSecuritiesAcquired>
        <paymentDate>05/04/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Dinesh Patel</name>
          <address>
            <com:street1>7707 GATEWAY BLVD., SUITE 140</com:street1>
            <com:city>Newark</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94560</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/01/2024</saleDate>
        <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
        <grossProceeds>707653</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>06/07/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/20/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Dinesh Patel.</signature>
      </noticeSignature>
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text: 144
  0001120477
  XXXXXXXX
  LIVE
  0001377121
  Protagonist Therapeutics, Inc.
  001-37852
  7707 Gateway Boulevard, Suite 140
  Newark
  CA
  94560
  5104740170
  Dinesh Patel
  CEO
  Commom
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  35000
  1180200
  58652133
  06/07/2024
  Nasdaq
  Common
  03/10/2017
  Option Exercise
  Issuer
  N
  10940
  03/10/2017
  Compensation
  Common
  04/06/2017
  Option Exercise
  Issuer
  N
  20000
  04/06/2017
  Compensation
  Common
  05/04/2022
  Option Exercise
  Issuer
  N
  4060
  05/04/2022
  Compensation
  N
  Dinesh Patel
  7707 GATEWAY BLVD., SUITE 140
  Newark
  CA
  94560
  Common
  04/01/2024
  25000
  707653
  06/07/2024
  03/20/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Dinesh Patel.