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            <ccc>XXXXXXXX</ccc>
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        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerName>Blueprint Medicines Corp</issuerName>
        <secFileNumber>001-37359</secFileNumber>
        <issuerAddress>
          <com:street1>45 SIDNEY STREET</com:street1>
          <com:city>CAMBRIDGE</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02139</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-374-7580</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Albers Jeffrey W.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>CITIGROUP GLOBAL MARKETS INC.</name>
          <address>
            <com:street1>CITIGROUP GLOBAL MARKETS INC.</com:street1>
            <com:street2>388 Greenwich Street</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10013</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>5000</noOfUnitsSold>
        <aggregateMarketValue>511398.50</aggregateMarketValue>
        <noOfUnitsOutstanding>6114723</noOfUnitsOutstanding>
        <approxSaleDate>01/13/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/16/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Grant of Vested Options</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
        <paymentDate>02/16/2021</paymentDate>
        <natureOfPayment>Compensation for services</natureOfPayment>
      </securitiesToBeSold>
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          <name>Jeffrey W. Albers</name>
          <address>
            <com:street1>c/o Blueprint Medicines Corp.</com:street1>
            <com:street2>45 Sydney Street</com:street2>
            <com:city>Cambridge </com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02139</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/19/2024</saleDate>
        <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
        <grossProceeds>1346633.00</grossProceeds>
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          <name>Jeffrey W. Albers</name>
          <address>
            <com:street1>c/o Blueprint Medicines Corp.</com:street1>
            <com:street2>45 Sydney Street</com:street2>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02139</com:zipCode>
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        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>11/07/2024</saleDate>
        <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
        <grossProceeds>510000.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>01/14/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>05/08/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Jeffrey W. Albers</signature>
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text: 144
  0001638474
  XXXXXXXX
  LIVE
  0001597264
  Blueprint Medicines Corp
  001-37359
  45 SIDNEY STREET
  CAMBRIDGE
  MA
  02139
  617-374-7580
  Albers Jeffrey W.
  Director
  Common
  CITIGROUP GLOBAL MARKETS INC.
  CITIGROUP GLOBAL MARKETS INC.
  388 Greenwich Street
  New York
  NY
  10013
  5000
  511398.50
  6114723
  01/13/2025
  NASDAQ
  Common
  02/16/2017
  Grant of Vested Options
  Issuer
  N
  5000
  02/16/2021
  Compensation for services
  N
  Jeffrey W. Albers
  c/o Blueprint Medicines Corp.
  45 Sydney Street
  Cambridge
  MA
  02139
  Common
  12/19/2024
  15000
  1346633.00
  Jeffrey W. Albers
  c/o Blueprint Medicines Corp.
  45 Sydney Street
  Cambridge
  MA
  02139
  Common
  11/07/2024
  5000
  510000.00
  01/14/2025
  05/08/2024
  /s/ Jeffrey W. Albers