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        <issuerName>Mineralys Therapeutics, Inc.</issuerName>
        <secFileNumber>001-41614</secFileNumber>
        <issuerAddress>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
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        <issuerContactPhone>(888) 378-6240</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Rodman David Malcom</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Merrill Lynch</name>
          <address>
            <com:street1>225 Liberty St</com:street1>
            <com:street2>Floor 37</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10281</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>226698</noOfUnitsSold>
        <aggregateMarketValue>2974277.76</aggregateMarketValue>
        <noOfUnitsOutstanding>40856653</noOfUnitsOutstanding>
        <approxSaleDate>08/10/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>08/10/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Exercise of employee stock options</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Mineralys Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>226698</amountOfSecuritiesAcquired>
        <paymentDate>08/10/2023</paymentDate>
        <natureOfPayment>Broker assisted cashless exercise</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>08/10/2023</noticeDate>
        <signature>David Rodman</signature>
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text: 144
  0001672659
  XXXXXXXX
  LIVE
  0001933414
  Mineralys Therapeutics, Inc.
  001-41614
  150 N. RADNOR CHESTER ROAD
  SUITE F200
  RADNOR
  PA
  19087
  (888) 378-6240
  Rodman David Malcom
  Officer
  Common Stock
  Merrill Lynch
  225 Liberty St
  Floor 37
  New York
  NY
  10281
  226698
  2974277.76
  40856653
  08/10/2023
  NASDAQ
  Common Stock
  08/10/2023
  Exercise of employee stock options
  Mineralys Therapeutics, Inc.
  N
  226698
  08/10/2023
  Broker assisted cashless exercise
  Y
  08/10/2023
  David Rodman