content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001671311</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001724521</issuerCik>
        <issuerName>Arcus Biosciences, Inc.</issuerName>
        <secFileNumber>001-38419</secFileNumber>
        <issuerAddress>
          <com:street1>3928 Point Eden Way</com:street1>
          <com:city>Hayward</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94545</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>510-694-6200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jennifer Jarrett</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>JP Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>57437</noOfUnitsSold>
        <aggregateMarketValue>1091877</aggregateMarketValue>
        <noOfUnitsOutstanding>73105580</noOfUnitsOutstanding>
        <approxSaleDate>06/22/2023</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/15/2023</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>12437</amountOfSecuritiesAcquired>
        <paymentDate>06/15/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/15/2021</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>16339</amountOfSecuritiesAcquired>
        <paymentDate>03/15/2021</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>15383</amountOfSecuritiesAcquired>
        <paymentDate>03/15/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>13278</amountOfSecuritiesAcquired>
        <paymentDate>12/15/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>06/22/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>02/22/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jennifer Jarrett</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4594}]
text: 144
  0001671311
  XXXXXXXX
  LIVE
  0001724521
  Arcus Biosciences, Inc.
  001-38419
  3928 Point Eden Way
  Hayward
  CA
  94545
  510-694-6200
  Jennifer Jarrett
  Officer
  Director
  Common
  JP Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  57437
  1091877
  73105580
  06/22/2023
  NYSE
  Common
  06/15/2023
  RSU Vesting
  Issuer
  N
  12437
  06/15/2023
  Compensation
  Common
  03/15/2021
  RSU Vesting
  Issuer
  N
  16339
  03/15/2021
  Compensation
  Common
  03/15/2022
  RSU Vesting
  Issuer
  N
  15383
  03/15/2022
  Compensation
  Common
  12/15/2022
  RSU Vesting
  Issuer
  N
  13278
  12/15/2022
  Compensation
  Y
  06/22/2023
  02/22/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jennifer Jarrett