content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001596080</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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    <formData>
      <issuerInfo>
        <issuerCik>0001531177</issuerCik>
        <issuerName>Sight Sciences, Inc.</issuerName>
        <secFileNumber>001-40587</secFileNumber>
        <issuerAddress>
          <com:street1>4040 CAMPBELL AVE,</com:street1>
          <com:street2>SUITE 100</com:street2>
          <com:city>MENLO PARK</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94025</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(415) 889-0550</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Bauerlein Alison</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>10497</noOfUnitsSold>
        <aggregateMarketValue>65204.21</aggregateMarketValue>
        <noOfUnitsOutstanding>49756252</noOfUnitsOutstanding>
        <approxSaleDate>07/02/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/28/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>10497</amountOfSecuritiesAcquired>
        <paymentDate>06/28/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Alison Bauerlein</name>
          <address>
            <com:street1>4040 Campbell Avenue</com:street1>
            <com:street2>Suite 100</com:street2>
            <com:city>Menlo Park</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94025</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/03/2024</saleDate>
        <amountOfSecuritiesSold>10123</amountOfSecuritiesSold>
        <grossProceeds>51412.69</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Alison Bauerlein</name>
          <address>
            <com:street1>4040 Campbell Avenue</com:street1>
            <com:street2>Suite 100</com:street2>
            <com:city>Menlo Park</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94025</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>05/17/2024</saleDate>
        <amountOfSecuritiesSold>13066</amountOfSecuritiesSold>
        <grossProceeds>70864.76</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>07/02/2024</noticeDate>
        <signature>/s/ Shawna Krumpelman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Alison Bauerlein</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001596080
  XXXXXXXX
  LIVE
  0001531177
  Sight Sciences, Inc.
  001-40587
  4040 CAMPBELL AVE,
  SUITE 100
  MENLO PARK
  CA
  94025
  (415) 889-0550
  Bauerlein Alison
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  10497
  65204.21
  49756252
  07/02/2024
  NASDAQ
  Common
  06/28/2024
  Restricted Stock Vesting
  Issuer
  N
  10497
  06/28/2024
  Compensation
  N
  Alison Bauerlein
  4040 Campbell Avenue
  Suite 100
  Menlo Park
  CA
  94025
  Common
  04/03/2024
  10123
  51412.69
  Alison Bauerlein
  4040 Campbell Avenue
  Suite 100
  Menlo Park
  CA
  94025
  Common
  05/17/2024
  13066
  70864.76
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  07/02/2024
  /s/ Shawna Krumpelman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Alison Bauerlein