content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001376620</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001337013</issuerCik>
        <issuerName>InfuSystem Holdings, Inc</issuerName>
        <secFileNumber>001-35020</secFileNumber>
        <issuerAddress>
          <com:street1>3851 WEST HAMLIN ROAD</com:street1>
          <com:city>ROCHESTER HILLS</com:city>
          <com:stateOrCountry>MI</com:stateOrCountry>
          <com:zipCode>48309</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(248) 291-1210</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Lehman Gregg Owen</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Merrill Lynch</name>
          <address>
            <com:street1>3455 Peachtree Rd NE</com:street1>
            <com:street2>Ste 1000</com:street2>
            <com:city>Atlanta</com:city>
            <com:stateOrCountry>GA</com:stateOrCountry>
            <com:zipCode>30326</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>25000</noOfUnitsSold>
        <aggregateMarketValue>227699.00</aggregateMarketValue>
        <noOfUnitsOutstanding>20931147</noOfUnitsOutstanding>
        <approxSaleDate>06/16/2023</approxSaleDate>
        <securitiesExchangeName>New York</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/16/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Exercise of a Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>INFUSYSTEM HOLDINGS, INC.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>25000</amountOfSecuritiesAcquired>
        <paymentDate>06/16/2023</paymentDate>
        <natureOfPayment>Compensatory Payment</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>06/16/2023</noticeDate>
        <signature>Gregg Owen Lehman</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001376620
  XXXXXXXX
  LIVE
  0001337013
  InfuSystem Holdings, Inc
  001-35020
  3851 WEST HAMLIN ROAD
  ROCHESTER HILLS
  MI
  48309
  (248) 291-1210
  Lehman Gregg Owen
  Officer
  Common
  Merrill Lynch
  3455 Peachtree Rd NE
  Ste 1000
  Atlanta
  GA
  30326
  25000
  227699.00
  20931147
  06/16/2023
  New York
  Common
  06/16/2023
  Exercise of a Stock Award
  INFUSYSTEM HOLDINGS, INC.
  N
  25000
  06/16/2023
  Compensatory Payment
  Y
  06/16/2023
  Gregg Owen Lehman