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        <filer>
          <filerCredentials>
            <cik>0001818525</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001528115</issuerCik>
        <issuerName>Annexon, Inc.</issuerName>
        <secFileNumber>001-39402</secFileNumber>
        <issuerAddress>
          <com:street1>1400 SIERRA POINT PARKWAY</com:street1>
          <com:street2>BLDG C, SUITE 200</com:street2>
          <com:city>BRISBANE</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94005</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(650)-822-5500</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Yednock Ted</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>2604</noOfUnitsSold>
        <aggregateMarketValue>14343.09</aggregateMarketValue>
        <noOfUnitsOutstanding>53238985</noOfUnitsOutstanding>
        <approxSaleDate>02/20/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/16/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2604</amountOfSecuritiesAcquired>
        <paymentDate>02/16/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ted Yednock</name>
          <address>
            <com:street1>1400 Sierra Point Parkway</com:street1>
            <com:street2>Bldg C, Suite 200</com:street2>
            <com:city>Brisbane</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94005</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/12/2024</saleDate>
        <amountOfSecuritiesSold>1810</amountOfSecuritiesSold>
        <grossProceeds>10019.80</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>02/20/2024</noticeDate>
        <signature>/s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Ted Yednock</signature>
      </noticeSignature>
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text: 144
  0001818525
  XXXXXXXX
  LIVE
  0001528115
  Annexon, Inc.
  001-39402
  1400 SIERRA POINT PARKWAY
  BLDG C, SUITE 200
  BRISBANE
  CA
  94005
  (650)-822-5500
  Yednock Ted
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  2604
  14343.09
  53238985
  02/20/2024
  NASDAQ
  Common
  02/16/2024
  Restricted Stock Vesting
  Issuer
  N
  2604
  02/16/2024
  Compensation
  N
  Ted Yednock
  1400 Sierra Point Parkway
  Bldg C, Suite 200
  Brisbane
  CA
  94005
  Common
  02/12/2024
  1810
  10019.80
  02/20/2024
  /s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Ted Yednock