content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
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        <filer>
          <filerCredentials>
            <cik>0001597947</cik>
            <ccc>XXXXXXXX</ccc>
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        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
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    <formData>
      <issuerInfo>
        <issuerCik>0001410384</issuerCik>
        <issuerName>Q2 Holdings, Inc.</issuerName>
        <secFileNumber>001-36350</secFileNumber>
        <issuerAddress>
          <com:street1>10355 PECAN PARK BOULEVARD</com:street1>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78729</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>1-833-444-3469</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Seale R. H.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>22300</noOfUnitsSold>
        <aggregateMarketValue>726821.31</aggregateMarketValue>
        <noOfUnitsOutstanding>58446532</noOfUnitsOutstanding>
        <approxSaleDate>09/15/2023</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>08/16/2004</acquiredDate>
        <natureOfAcquisitionTransaction>Initial Investment</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>22300</amountOfSecuritiesAcquired>
        <paymentDate>08/16/2004</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>RHS Investments - I LP</name>
          <address>
            <com:street1>c/o Q2 Holdings, Inc.</com:street1>
            <com:street2>10355 Pecan Park Boulevard</com:street2>
            <com:city>Austin</com:city>
            <com:stateOrCountry>TX</com:stateOrCountry>
            <com:zipCode>78729</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>07/14/2023</saleDate>
        <amountOfSecuritiesSold>22300</amountOfSecuritiesSold>
        <grossProceeds>742168.92</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>RHS Investments - I LP</name>
          <address>
            <com:street1>c/o Q2 Holdings, Inc.</com:street1>
            <com:street2>10355 Pecan Park Boulevard</com:street2>
            <com:city>Austin</com:city>
            <com:stateOrCountry>TX</com:stateOrCountry>
            <com:zipCode>78729</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>08/11/2023</saleDate>
        <amountOfSecuritiesSold>22300</amountOfSecuritiesSold>
        <grossProceeds>747813.68</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Robert H. Seale</name>
          <address>
            <com:street1>c/o Q2 Holdings, Inc.</com:street1>
            <com:street2>10355 Pecan Park Boulevard</com:street2>
            <com:city>Austin</com:city>
            <com:stateOrCountry>TX</com:stateOrCountry>
            <com:zipCode>78729</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>09/11/2023</saleDate>
        <amountOfSecuritiesSold>565</amountOfSecuritiesSold>
        <grossProceeds>18836.43</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Shares sold for RHS Investments-I, LP where Robert H. Seale is President of Seale Inc., GP</remarks>
      <noticeSignature>
        <noticeDate>09/15/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>11/21/2022</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Myra King, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Robert H. Seale</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001597947
  XXXXXXXX
  LIVE
  0001410384
  Q2 Holdings, Inc.
  001-36350
  10355 PECAN PARK BOULEVARD
  Austin
  TX
  78729
  1-833-444-3469
  Seale R. H.
  Director
  Common Stock
  Fidelity Brokerage Services LLC
  245 Summer Street
  Boston
  MA
  02110
  22300
  726821.31
  58446532
  09/15/2023
  NYSE
  Common Stock
  08/16/2004
  Initial Investment
  Issuer
  N
  22300
  08/16/2004
  Cash
  N
  RHS Investments - I LP
  c/o Q2 Holdings, Inc.
  10355 Pecan Park Boulevard
  Austin
  TX
  78729
  Common Stock
  07/14/2023
  22300
  742168.92
  RHS Investments - I LP
  c/o Q2 Holdings, Inc.
  10355 Pecan Park Boulevard
  Austin
  TX
  78729
  Common Stock
  08/11/2023
  22300
  747813.68
  Robert H. Seale
  c/o Q2 Holdings, Inc.
  10355 Pecan Park Boulevard
  Austin
  TX
  78729
  Common Stock
  09/11/2023
  565
  18836.43
  Shares sold for RHS Investments-I, LP where Robert H. Seale is President of Seale Inc., GP
  09/15/2023
  11/21/2022
  /s/ Myra King, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Robert H. Seale