content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001497582</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000103145</issuerCik>
        <issuerName>Veeco Instruments Inc</issuerName>
        <secFileNumber>000-16244</secFileNumber>
        <issuerAddress>
          <com:street1>1 Terminal Drive</com:street1>
          <com:city>Plainview</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>11803</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>516-677-2022</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>William  J Miller</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>24201</noOfUnitsSold>
        <aggregateMarketValue>854053.29</aggregateMarketValue>
        <noOfUnitsOutstanding>56341738</noOfUnitsOutstanding>
        <approxSaleDate>03/21/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/14/2017</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vest</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1333</amountOfSecuritiesAcquired>
        <paymentDate>06/14/2017</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/12/2017</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vest</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2533</amountOfSecuritiesAcquired>
        <paymentDate>06/12/2017</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/13/2016</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vest</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>5633</amountOfSecuritiesAcquired>
        <paymentDate>12/13/2016</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/10/2017</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vest</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3155</amountOfSecuritiesAcquired>
        <paymentDate>07/10/2017</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/17/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vest</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6652</amountOfSecuritiesAcquired>
        <paymentDate>03/17/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/14/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vest</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4895</amountOfSecuritiesAcquired>
        <paymentDate>03/14/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>William J Miller</name>
          <address>
            <com:street1>Care of Veeco Instruments Inc</com:street1>
            <com:street2>1 Terminal Drive</com:street2>
            <com:city>Plainview</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>11803</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>01/17/2024</saleDate>
        <amountOfSecuritiesSold>30000</amountOfSecuritiesSold>
        <grossProceeds>902076</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>03/21/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>08/23/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for William J Miller</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001497582
  XXXXXXXX
  LIVE
  0000103145
  Veeco Instruments Inc
  000-16244
  1 Terminal Drive
  Plainview
  NY
  11803
  516-677-2022
  William  J Miller
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  24201
  854053.29
  56341738
  03/21/2024
  NASDAQ
  Common
  06/14/2017
  RSU Vest
  Issuer
  N
  1333
  06/14/2017
  Compensation
  Common
  06/12/2017
  RSU Vest
  Issuer
  N
  2533
  06/12/2017
  Compensation
  Common
  12/13/2016
  RSU Vest
  Issuer
  N
  5633
  12/13/2016
  Compensation
  Common
  07/10/2017
  RSU Vest
  Issuer
  N
  3155
  07/10/2017
  Compensation
  Common
  03/17/2022
  RSU Vest
  Issuer
  N
  6652
  03/17/2022
  Compensation
  Common
  03/14/2022
  RSU Vest
  Issuer
  N
  4895
  03/14/2022
  Compensation
  N
  William J Miller
  Care of Veeco Instruments Inc
  1 Terminal Drive
  Plainview
  NY
  11803
  Common
  01/17/2024
  30000
  902076
  03/21/2024
  08/23/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for William J Miller