content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001790865</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001676725</issuerCik>
        <issuerName>IDEAYA Biosciences, Inc.</issuerName>
        <secFileNumber>001-38915</secFileNumber>
        <issuerAddress>
          <com:street1>7000 Shoreline Court</com:street1>
          <com:street2>Suite 350</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>6504436209</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jason Throne</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>14485</noOfUnitsSold>
        <aggregateMarketValue>330403</aggregateMarketValue>
        <noOfUnitsOutstanding>57290177</noOfUnitsOutstanding>
        <approxSaleDate>07/10/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/10/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>14485</amountOfSecuritiesAcquired>
        <paymentDate>07/10/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Jason Throne</name>
          <address>
            <com:street1>7000 Shoreline Court</com:street1>
            <com:street2>Suite 350</com:street2>
            <com:city>San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>05/22/2023</saleDate>
        <amountOfSecuritiesSold>500</amountOfSecuritiesSold>
        <grossProceeds>11500</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Jason Throne</name>
          <address>
            <com:street1>7000 Shoreline Court</com:street1>
            <com:street2>Suite 350</com:street2>
            <com:city>San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>05/31/2023</saleDate>
        <amountOfSecuritiesSold>432</amountOfSecuritiesSold>
        <grossProceeds>9937</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Jason Throne</name>
          <address>
            <com:street1>7000 Shoreline Court</com:street1>
            <com:street2>Suite 350</com:street2>
            <com:city>San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>06/01/2023</saleDate>
        <amountOfSecuritiesSold>3553</amountOfSecuritiesSold>
        <grossProceeds>81792</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>07/10/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/29/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jason Throne</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4910}]
text: 144
  0001790865
  XXXXXXXX
  LIVE
  0001676725
  IDEAYA Biosciences, Inc.
  001-38915
  7000 Shoreline Court
  Suite 350
  San Francisco
  CA
  94080
  6504436209
  Jason Throne
  Officer
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  14485
  330403
  57290177
  07/10/2023
  Nasdaq
  Common
  07/10/2023
  Stock Option Exercise
  Issuer
  N
  14485
  07/10/2023
  Cash
  N
  Jason Throne
  7000 Shoreline Court
  Suite 350
  San Francisco
  CA
  94080
  Common Stock
  05/22/2023
  500
  11500
  Jason Throne
  7000 Shoreline Court
  Suite 350
  San Francisco
  CA
  94080
  Common Stock
  05/31/2023
  432
  9937
  Jason Throne
  7000 Shoreline Court
  Suite 350
  San Francisco
  CA
  94080
  Common Stock
  06/01/2023
  3553
  81792
  07/10/2023
  03/29/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jason Throne