content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001247296</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001124140</issuerCik>
        <issuerName>EXACT SCIENCES CORP</issuerName>
        <secFileNumber>001-35092</secFileNumber>
        <issuerAddress>
          <com:street1>5505 ENDEAVOR LANE</com:street1>
          <com:city>MADISON</com:city>
          <com:stateOrCountry>WI</com:stateOrCountry>
          <com:zipCode>53719</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>608-284-5700</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>COWARD D SCOTT</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1376</noOfUnitsSold>
        <aggregateMarketValue>84527.40</aggregateMarketValue>
        <noOfUnitsOutstanding>180849944</noOfUnitsOutstanding>
        <approxSaleDate>02/15/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/14/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1376</amountOfSecuritiesAcquired>
        <paymentDate>02/14/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>David S Coward and D Scott Coward are one and the same person.</remarks>
      <noticeSignature>
        <noticeDate>02/15/2024</noticeDate>
        <signature>/s/ Gary Redman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for David S. Coward</signature>
      </noticeSignature>
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text: 144
  0001247296
  XXXXXXXX
  LIVE
  0001124140
  EXACT SCIENCES CORP
  001-35092
  5505 ENDEAVOR LANE
  MADISON
  WI
  53719
  608-284-5700
  COWARD D SCOTT
  Former Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  1376
  84527.40
  180849944
  02/15/2024
  NASDAQ
  Common
  02/14/2024
  Restricted Stock Vesting
  Issuer
  N
  1376
  02/14/2024
  Compensation
  Y
  David S Coward and D Scott Coward are one and the same person.
  02/15/2024
  /s/ Gary Redman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for David S. Coward