content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001251708</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000103145</issuerCik>
        <issuerName>Veeco Instruments, Inc.</issuerName>
        <secFileNumber>000-16244</secFileNumber>
        <issuerAddress>
          <com:street1>1 Terminal Drive</com:street1>
          <com:city>Plainview</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>11803</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>516-677-0200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>John Kiernan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>7500</noOfUnitsSold>
        <aggregateMarketValue>221550</aggregateMarketValue>
        <noOfUnitsOutstanding>56784837</noOfUnitsOutstanding>
        <approxSaleDate>09/10/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/22/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>7500</amountOfSecuritiesAcquired>
        <paymentDate>03/22/2023</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>John Kiernan</name>
          <address>
            <com:street1>1 Terminal Drive</com:street1>
            <com:city>Plainview</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>11803</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>07/10/2024</saleDate>
        <amountOfSecuritiesSold>2500</amountOfSecuritiesSold>
        <grossProceeds>121138</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>John Kiernan</name>
          <address>
            <com:street1>1 Terminal Drive</com:street1>
            <com:city>Plainview</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>11803</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>08/12/2024</saleDate>
        <amountOfSecuritiesSold>2500</amountOfSecuritiesSold>
        <grossProceeds>91208</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>09/10/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>02/29/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for John Kiernan</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4066}]
text: 144
  0001251708
  XXXXXXXX
  LIVE
  0000103145
  Veeco Instruments, Inc.
  000-16244
  1 Terminal Drive
  Plainview
  NY
  11803
  516-677-0200
  John Kiernan
  Officer
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  7500
  221550
  56784837
  09/10/2024
  NASDAQ
  Common
  03/22/2023
  Restricted Stock Award
  Issuer
  N
  7500
  03/22/2023
  N/A
  N
  John Kiernan
  1 Terminal Drive
  Plainview
  NY
  11803
  Common
  07/10/2024
  2500
  121138
  John Kiernan
  1 Terminal Drive
  Plainview
  NY
  11803
  Common
  08/12/2024
  2500
  91208
  09/10/2024
  02/29/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for John Kiernan