content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001695434</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001069258</issuerCik>
        <issuerName>KRATOS DEFENSE &amp; SECURITY SOLUTIONS, INC.</issuerName>
        <secFileNumber>001-34460</secFileNumber>
        <issuerAddress>
          <com:street1>10680 TREENA STREET</com:street1>
          <com:street2>SUITE 600</com:street2>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92131</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>858-812-7300</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Fendley Steven S.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>7000</noOfUnitsSold>
        <aggregateMarketValue>163606.52</aggregateMarketValue>
        <noOfUnitsOutstanding>150999300</noOfUnitsOutstanding>
        <approxSaleDate>09/30/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>01/04/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Share Grant</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Kratos Defense &amp; Security Solutions, Inc.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3254</amountOfSecuritiesAcquired>
        <paymentDate>01/04/2022</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock	</securitiesClassTitle>
        <acquiredDate>01/03/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Share Grant	</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Kratos Defense &amp; Security Solutions, Inc.	</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3746</amountOfSecuritiesAcquired>
        <paymentDate>01/03/2022</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Steven S. Fendley</name>
          <address>
            <com:street1>c/o Kratos Defense &amp; Security Solutions</com:street1>
            <com:street2>1 Chisholm Trail, Suite 300</com:street2>
            <com:city>Round Rock</com:city>
            <com:stateOrCountry>TX</com:stateOrCountry>
            <com:zipCode>78681</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>07/29/2024</saleDate>
        <amountOfSecuritiesSold>7000</amountOfSecuritiesSold>
        <grossProceeds>158766.77</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Steven S. Fendley</name>
          <address>
            <com:street1>c/o Kratos Defense &amp; Security Solutions,</com:street1>
            <com:street2>1 Chisholm Trail, Suite 300</com:street2>
            <com:city>Round Rock</com:city>
            <com:stateOrCountry>TX</com:stateOrCountry>
            <com:zipCode>78681</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock	</securitiesClassTitle>
        <saleDate>08/26/2024</saleDate>
        <amountOfSecuritiesSold>7000</amountOfSecuritiesSold>
        <grossProceeds>158026.90</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>09/30/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>05/20/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Audrey Skillern, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Steven S. Fendley</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4980}]
text: 144
  0001695434
  XXXXXXXX
  LIVE
  0001069258
  KRATOS DEFENSE & SECURITY SOLUTIONS, INC.
  001-34460
  10680 TREENA STREET
  SUITE 600
  SAN DIEGO
  CA
  92131
  858-812-7300
  Fendley Steven S.
  Officer
  Common Stock
  Fidelity Brokerage Services LLC
  245 Summer Street
  Boston
  MA
  02110
  7000
  163606.52
  150999300
  09/30/2024
  NASDAQ
  Common Stock
  01/04/2022
  Share Grant
  Kratos Defense & Security Solutions, Inc.
  N
  3254
  01/04/2022
  N/A
  Common Stock
  01/03/2022
  Share Grant
  Kratos Defense & Security Solutions, Inc.
  N
  3746
  01/03/2022
  N/A
  N
  Steven S. Fendley
  c/o Kratos Defense & Security Solutions
  1 Chisholm Trail, Suite 300
  Round Rock
  TX
  78681
  Common Stock
  07/29/2024
  7000
  158766.77
  Steven S. Fendley
  c/o Kratos Defense & Security Solutions,
  1 Chisholm Trail, Suite 300
  Round Rock
  TX
  78681
  Common Stock
  08/26/2024
  7000
  158026.90
  09/30/2024
  05/20/2024
  /s/ Audrey Skillern, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Steven S. Fendley