content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001450485</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001314102</issuerCik>
        <issuerName>EyePoint Pharmaceuticals, Inc.</issuerName>
        <secFileNumber>000-51122</secFileNumber>
        <issuerAddress>
          <com:street1>480 PLEASANT STREET</com:street1>
          <com:street2>SUITE B300</com:street2>
          <com:city>WATERTOWN</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02472</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-926-5000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Lurker Nancy</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>20000</noOfUnitsSold>
        <aggregateMarketValue>415164.00</aggregateMarketValue>
        <noOfUnitsOutstanding>35309432</noOfUnitsOutstanding>
        <approxSaleDate>12/04/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>06/27/2018</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase/RSU's</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market Purchase/Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1586</amountOfSecuritiesAcquired>
        <paymentDate>06/27/2018</paymentDate>
        <natureOfPayment>Cash/Stock Option</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>10/12/2018</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase/RSU's</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market Purchase/Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3833</amountOfSecuritiesAcquired>
        <paymentDate>10/12/2018</paymentDate>
        <natureOfPayment>Cash/Stock Option</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/19/2019</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase/RSU's</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market Purchase/Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1916</amountOfSecuritiesAcquired>
        <paymentDate>03/19/2019</paymentDate>
        <natureOfPayment>Cash/Stock Option</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/29/2019</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase/RSU's</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market Purchase/Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2850</amountOfSecuritiesAcquired>
        <paymentDate>03/29/2019</paymentDate>
        <natureOfPayment>Cash/Stock Option</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>06/14/2019</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase/RSU's</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market Purchase/Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4500</amountOfSecuritiesAcquired>
        <paymentDate>06/14/2019</paymentDate>
        <natureOfPayment>Cash/Stock Option</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>06/27/2019</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase/RSU's</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market Purchase/Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4000</amountOfSecuritiesAcquired>
        <paymentDate>06/27/2019</paymentDate>
        <natureOfPayment>Cash/Stock Option</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>10/12/2019</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase/RSU's</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market Purchase/Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1315</amountOfSecuritiesAcquired>
        <paymentDate>10/12/2019</paymentDate>
        <natureOfPayment>Cash/Stock Option</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/04/2023</noticeDate>
        <signature>/s/ Myra King, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Nancy Lurker</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6351}]
text: 144
  0001450485
  XXXXXXXX
  LIVE
  0001314102
  EyePoint Pharmaceuticals, Inc.
  000-51122
  480 PLEASANT STREET
  SUITE B300
  WATERTOWN
  MA
  02472
  617-926-5000
  Lurker Nancy
  Director
  Common Stock
  Fidelity Brokerage Services LLC
  245 Summer Street
  Boston
  MA
  02110
  20000
  415164.00
  35309432
  12/04/2023
  NASDAQ
  Common Stock
  06/27/2018
  Open Market Purchase/RSU's
  Open Market Purchase/Issuer
  N
  1586
  06/27/2018
  Cash/Stock Option
  Common Stock
  10/12/2018
  Open Market Purchase/RSU's
  Open Market Purchase/Issuer
  N
  3833
  10/12/2018
  Cash/Stock Option
  Common Stock
  03/19/2019
  Open Market Purchase/RSU's
  Open Market Purchase/Issuer
  N
  1916
  03/19/2019
  Cash/Stock Option
  Common Stock
  03/29/2019
  Open Market Purchase/RSU's
  Open Market Purchase/Issuer
  N
  2850
  03/29/2019
  Cash/Stock Option
  Common Stock
  06/14/2019
  Open Market Purchase/RSU's
  Open Market Purchase/Issuer
  N
  4500
  06/14/2019
  Cash/Stock Option
  Common Stock
  06/27/2019
  Open Market Purchase/RSU's
  Open Market Purchase/Issuer
  N
  4000
  06/27/2019
  Cash/Stock Option
  Common Stock
  10/12/2019
  Open Market Purchase/RSU's
  Open Market Purchase/Issuer
  N
  1315
  10/12/2019
  Cash/Stock Option
  Y
  12/04/2023
  /s/ Myra King, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Nancy Lurker