content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001871937</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001805651</issuerCik>
        <issuerName>MARKETWISE, INC.</issuerName>
        <secFileNumber>001-39405</secFileNumber>
        <issuerAddress>
          <com:street1>667 MADISON AVENUE</com:street1>
          <com:street2>5TH FLOOR</com:street2>
          <com:city>NEW YORK</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10065</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(212) 209-6126</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Anderson Gary Daniel</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1000</noOfUnitsSold>
        <aggregateMarketValue>3010.10</aggregateMarketValue>
        <noOfUnitsOutstanding>39147437</noOfUnitsOutstanding>
        <approxSaleDate>11/17/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <acquiredDate>06/30/2022</acquiredDate>
        <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1000</amountOfSecuritiesAcquired>
        <paymentDate>06/30/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Gary Anderson</name>
          <address>
            <com:street1>1125 N. Charles Street</com:street1>
            <com:city>Baltimore</com:city>
            <com:stateOrCountry>MD</com:stateOrCountry>
            <com:zipCode>21201</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A</securitiesClassTitle>
        <saleDate>10/20/2023</saleDate>
        <amountOfSecuritiesSold>2320</amountOfSecuritiesSold>
        <grossProceeds>3866.28</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/17/2023</noticeDate>
        <signature>/s/ Courtney Broxterman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Gary Anderson</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001871937
  XXXXXXXX
  LIVE
  0001805651
  MARKETWISE, INC.
  001-39405
  667 MADISON AVENUE
  5TH FLOOR
  NEW YORK
  NY
  10065
  (212) 209-6126
  Anderson Gary Daniel
  Officer
  Class A
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  1000
  3010.10
  39147437
  11/17/2023
  NASDAQ
  Class A
  06/30/2022
  ESPP Purchase
  Issuer
  N
  1000
  06/30/2022
  Cash
  N
  Gary Anderson
  1125 N. Charles Street
  Baltimore
  MD
  21201
  Class A
  10/20/2023
  2320
  3866.28
  11/17/2023
  /s/ Courtney Broxterman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Gary Anderson