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      <filerInfo>
        <filer>
          <filerCredentials>
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            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001267565</issuerCik>
        <issuerName>COLLEGIUM PHARMACEUTICAL, INC</issuerName>
        <secFileNumber>001-37372</secFileNumber>
        <issuerAddress>
          <com:street1>100 TECHNOLOGY CENTER DRIVE</com:street1>
          <com:city>STOUGHTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02072</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>781-713-3699</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Tupper Colleen</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>6396</noOfUnitsSold>
        <aggregateMarketValue>192068.63</aggregateMarketValue>
        <noOfUnitsOutstanding>31485523</noOfUnitsOutstanding>
        <approxSaleDate>03/21/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/10/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6396</amountOfSecuritiesAcquired>
        <paymentDate>02/10/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Colleen Tupper</name>
          <address>
            <com:street1>100 Technology Center Drive</com:street1>
            <com:city>Stoughton</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02072</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>03/06/2025</saleDate>
        <amountOfSecuritiesSold>1949</amountOfSecuritiesSold>
        <grossProceeds>58470.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Colleen Tupper</name>
          <address>
            <com:street1>100 Technology Center Drive</com:street1>
            <com:city>Stoughton</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02072</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>03/07/2025</saleDate>
        <amountOfSecuritiesSold>1504</amountOfSecuritiesSold>
        <grossProceeds>45121.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Colleen Tupper</name>
          <address>
            <com:street1>100 Technology Center Drive</com:street1>
            <com:city>Stoughton</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02072</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>03/11/2025</saleDate>
        <amountOfSecuritiesSold>10445</amountOfSecuritiesSold>
        <grossProceeds>313412.77</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Colleen Tupper</name>
          <address>
            <com:street1>100 Technology Center Drive</com:street1>
            <com:city>Stoughton</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02072</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>03/14/2025</saleDate>
        <amountOfSecuritiesSold>977</amountOfSecuritiesSold>
        <grossProceeds>29313.32</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Colleen Tupper</name>
          <address>
            <com:street1>100 Technology Center Drive</com:street1>
            <com:city>Stoughton</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02072</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>03/20/2025</saleDate>
        <amountOfSecuritiesSold>1206</amountOfSecuritiesSold>
        <grossProceeds>36181.38</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>03/21/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>08/14/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Colleen Tupper</signature>
      </noticeSignature>
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text: 144
  0001862082
  XXXXXXXX
  LIVE
  0001267565
  COLLEGIUM PHARMACEUTICAL, INC
  001-37372
  100 TECHNOLOGY CENTER DRIVE
  STOUGHTON
  MA
  02072
  781-713-3699
  Tupper Colleen
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  6396
  192068.63
  31485523
  03/21/2025
  NASDAQ
  Common
  02/10/2025
  Restricted Stock Vesting
  Issuer
  N
  6396
  02/10/2025
  Compensation
  N
  Colleen Tupper
  100 Technology Center Drive
  Stoughton
  MA
  02072
  Common
  03/06/2025
  1949
  58470.00
  Colleen Tupper
  100 Technology Center Drive
  Stoughton
  MA
  02072
  Common
  03/07/2025
  1504
  45121.00
  Colleen Tupper
  100 Technology Center Drive
  Stoughton
  MA
  02072
  Common
  03/11/2025
  10445
  313412.77
  Colleen Tupper
  100 Technology Center Drive
  Stoughton
  MA
  02072
  Common
  03/14/2025
  977
  29313.32
  Colleen Tupper
  100 Technology Center Drive
  Stoughton
  MA
  02072
  Common
  03/20/2025
  1206
  36181.38
  03/21/2025
  08/14/2024
  /s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Colleen Tupper