content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
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      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001497582</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
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      <issuerInfo>
        <issuerCik>0000103145</issuerCik>
        <issuerName>Veeco Instruments, Inc.</issuerName>
        <secFileNumber>000-16244</secFileNumber>
        <issuerAddress>
          <com:street1>1 Terminal Drive</com:street1>
          <com:city>Plainview</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>11803</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>516-677-0200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>William Miller</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>30000</noOfUnitsSold>
        <aggregateMarketValue>870000</aggregateMarketValue>
        <noOfUnitsOutstanding>56341738</noOfUnitsOutstanding>
        <approxSaleDate>11/27/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/18/2022</acquiredDate>
        <natureOfAcquisitionTransaction>PSU Vest</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>30000</amountOfSecuritiesAcquired>
        <paymentDate>03/18/2022</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/27/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>08/23/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for William Miller</signature>
      </noticeSignature>
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text: 144
  0001497582
  XXXXXXXX
  LIVE
  0000103145
  Veeco Instruments, Inc.
  000-16244
  1 Terminal Drive
  Plainview
  NY
  11803
  516-677-0200
  William Miller
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  30000
  870000
  56341738
  11/27/2023
  NASDAQ
  Common
  03/18/2022
  PSU Vest
  Issuer
  N
  30000
  03/18/2022
  N/A
  Y
  11/27/2023
  08/23/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for William Miller