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          <filerCredentials>
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            <ccc>XXXXXXXX</ccc>
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        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001590750</issuerCik>
        <issuerName>Viridian Therapeutics, Inc.\DE</issuerName>
        <secFileNumber>001-36483</secFileNumber>
        <issuerAddress>
          <com:street1>221 CRESCENT STREET</com:street1>
          <com:street2>BLDG. 17, SUITE 401</com:street2>
          <com:city>WALTHAM</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02453</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617.272.4600</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Humer Kristian</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former CFO</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>252600</noOfUnitsSold>
        <aggregateMarketValue>4334667.06</aggregateMarketValue>
        <noOfUnitsOutstanding>52586039</noOfUnitsOutstanding>
        <approxSaleDate>12/12/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/12/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted - 07/26/2021</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>252600</amountOfSecuritiesAcquired>
        <paymentDate>12/12/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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          <name>Kristian Humer</name>
          <address>
            <com:street1>221 Crescent Street</com:street1>
            <com:street2>Suite 401</com:street2>
            <com:city>Waltham</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02453</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/07/2023</saleDate>
        <amountOfSecuritiesSold>24900</amountOfSecuritiesSold>
        <grossProceeds>470859.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/12/2023</noticeDate>
        <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Kristian Humer</signature>
      </noticeSignature>
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text: 144
  0001872280
  XXXXXXXX
  LIVE
  0001590750
  Viridian Therapeutics, Inc.\DE
  001-36483
  221 CRESCENT STREET
  BLDG. 17, SUITE 401
  WALTHAM
  MA
  02453
  617.272.4600
  Humer Kristian
  Former CFO
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  252600
  4334667.06
  52586039
  12/12/2023
  NASDAQ
  Common
  12/12/2023
  Option Granted - 07/26/2021
  Issuer
  N
  252600
  12/12/2023
  Cash
  N
  Kristian Humer
  221 Crescent Street
  Suite 401
  Waltham
  MA
  02453
  Common
  12/07/2023
  24900
  470859.00
  12/12/2023
  /s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Kristian Humer