content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001790029</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000875320</issuerCik>
        <issuerName>VERTEX PHARMACEUTICALS INC / MA</issuerName>
        <secFileNumber>000-19319</secFileNumber>
        <issuerAddress>
          <com:street1>50 NORTHERN AVENUE</com:street1>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>6173416393</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Bozic Carmen</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>2280</noOfUnitsSold>
        <aggregateMarketValue>1113688.80</aggregateMarketValue>
        <noOfUnitsOutstanding>258053387</noOfUnitsOutstanding>
        <approxSaleDate>07/24/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/20/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1028</amountOfSecuritiesAcquired>
        <paymentDate>02/20/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/24/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1252</amountOfSecuritiesAcquired>
        <paymentDate>02/24/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Carmen R. Bozic</name>
          <address>
            <com:street1>50 Northern Avenue</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>05/29/2024</saleDate>
        <amountOfSecuritiesSold>2280</amountOfSecuritiesSold>
        <grossProceeds>1015878.80</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Carmen R. Bozic</name>
          <address>
            <com:street1>50 Northern Avenue</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>06/12/2024</saleDate>
        <amountOfSecuritiesSold>2280</amountOfSecuritiesSold>
        <grossProceeds>1089840.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Carmen R. Bozic</name>
          <address>
            <com:street1>50 Northern Avenue</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>06/26/2024</saleDate>
        <amountOfSecuritiesSold>2280</amountOfSecuritiesSold>
        <grossProceeds>1075521.60</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Carmen R. Bozic</name>
          <address>
            <com:street1>50 Northern Avenue</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>07/10/2024</saleDate>
        <amountOfSecuritiesSold>2280</amountOfSecuritiesSold>
        <grossProceeds>1111135.20</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>07/24/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>02/27/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Carmen R Bozic </signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5813}]
text: 144
  0001790029
  XXXXXXXX
  LIVE
  0000875320
  VERTEX PHARMACEUTICALS INC / MA
  000-19319
  50 NORTHERN AVENUE
  BOSTON
  MA
  02210
  6173416393
  Bozic Carmen
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  2280
  1113688.80
  258053387
  07/24/2024
  NASDAQ
  Common
  02/20/2024
  Restricted Stock Vesting
  Issuer
  N
  1028
  02/20/2024
  Compensation
  Common
  02/24/2024
  Restricted Stock Vesting
  Issuer
  N
  1252
  02/24/2024
  Compensation
  N
  Carmen R. Bozic
  50 Northern Avenue
  Boston
  MA
  02210
  Common
  05/29/2024
  2280
  1015878.80
  Carmen R. Bozic
  50 Northern Avenue
  Boston
  MA
  02210
  Common
  06/12/2024
  2280
  1089840.00
  Carmen R. Bozic
  50 Northern Avenue
  Boston
  MA
  02210
  Common
  06/26/2024
  2280
  1075521.60
  Carmen R. Bozic
  50 Northern Avenue
  Boston
  MA
  02210
  Common
  07/10/2024
  2280
  1111135.20
  07/24/2024
  02/27/2024
  /s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Carmen R Bozic