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            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001401667</issuerCik>
        <issuerName>PUMA BIOTECHNOLOGY, INC.</issuerName>
        <secFileNumber>001-35703</secFileNumber>
        <issuerAddress>
          <com:street1>10880 WILSHIRE BLVD.</com:street1>
          <com:street2>SUITE 2150</com:street2>
          <com:city>LOS ANGELES</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>90024</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(424) 248-6500</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MILLER MICHAEL PATRICK</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Muriel Siebert &amp; Co., Inc.</name>
          <address>
            <com:street1>4141 NE 2nd Avenue, Suite 201</com:street1>
            <com:city>Miami</com:city>
            <com:stateOrCountry>FL</com:stateOrCountry>
            <com:zipCode>33137</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>25000</noOfUnitsSold>
        <aggregateMarketValue>70250.00</aggregateMarketValue>
        <noOfUnitsOutstanding>47571332</noOfUnitsOutstanding>
        <approxSaleDate>11/07/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQGS</securitiesExchangeName>
      </securitiesInformation>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>06/15/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Grant of Restricted Stock Units</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>PUMA BIOTECHNOLOGY, INC.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>14358</amountOfSecuritiesAcquired>
        <paymentDate>06/15/2021</paymentDate>
        <natureOfPayment>Compensation for Services Rendered</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>06/14/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Grant of Restricted Stock Units</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>PUMA BIOTECHNOLOGY, INC.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>27000</amountOfSecuritiesAcquired>
        <paymentDate>06/14/2022</paymentDate>
        <natureOfPayment>Compensation for Services Rendered</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/07/2023</noticeDate>
        <signature>/s/ Gordon Esplin, Attorney-in-Fact for Michael P. Miller</signature>
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text: 144
  0001236514
  XXXXXXXX
  LIVE
  0001401667
  PUMA BIOTECHNOLOGY, INC.
  001-35703
  10880 WILSHIRE BLVD.
  SUITE 2150
  LOS ANGELES
  CA
  90024
  (424) 248-6500
  MILLER MICHAEL PATRICK
  Director
  Common Stock
  Muriel Siebert & Co., Inc.
  4141 NE 2nd Avenue, Suite 201
  Miami
  FL
  33137
  25000
  70250.00
  47571332
  11/07/2023
  NASDAQGS
  Common Stock
  06/15/2021
  Grant of Restricted Stock Units
  PUMA BIOTECHNOLOGY, INC.
  N
  14358
  06/15/2021
  Compensation for Services Rendered
  Common Stock
  06/14/2022
  Grant of Restricted Stock Units
  PUMA BIOTECHNOLOGY, INC.
  N
  27000
  06/14/2022
  Compensation for Services Rendered
  Y
  11/07/2023
  /s/ Gordon Esplin, Attorney-in-Fact for Michael P. Miller