content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001786322</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001745999</issuerCik>
        <issuerName>Beam Therapeutics Inc.</issuerName>
        <secFileNumber>001-39208</secFileNumber>
        <issuerAddress>
          <com:street1>238 Main Street</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>857-327-8775</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Giuseppe Ciaramella</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>102220</noOfUnitsSold>
        <aggregateMarketValue>2519723</aggregateMarketValue>
        <noOfUnitsOutstanding>82415619</noOfUnitsOutstanding>
        <approxSaleDate>10/14/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/31/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4361</amountOfSecuritiesAcquired>
        <paymentDate>03/31/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/31/2023</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2616</amountOfSecuritiesAcquired>
        <paymentDate>03/31/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/31/2024</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3489</amountOfSecuritiesAcquired>
        <paymentDate>03/31/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/20/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>45500</amountOfSecuritiesAcquired>
        <paymentDate>10/20/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/30/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4500</amountOfSecuritiesAcquired>
        <paymentDate>12/30/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/14/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>41754</amountOfSecuritiesAcquired>
        <paymentDate>10/14/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Some of the shares covered by this filing are stock options that will be exercised within three months from the date of this filing. Sales that were executed on October 14, 2024  are being reported on this Form 144 filed today given the EDGAR system was not accepting filings on October 14, 2024 in observance of the federal holiday.</remarks>
      <noticeSignature>
        <noticeDate>10/15/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>06/28/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Giuseppe Ciaramella</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5940}]
text: 144
  0001786322
  XXXXXXXX
  LIVE
  0001745999
  Beam Therapeutics Inc.
  001-39208
  238 Main Street
  Cambridge
  MA
  02142
  857-327-8775
  Giuseppe Ciaramella
  Officer
  Common Stock
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  102220
  2519723
  82415619
  10/14/2024
  NASDAQ
  Common Stock
  03/31/2022
  RSU Vesting
  Issuer
  N
  4361
  03/31/2022
  Compensation
  Common Stock
  03/31/2023
  RSU Vesting
  Issuer
  N
  2616
  03/31/2023
  Compensation
  Common Stock
  03/31/2024
  RSU Vesting
  Issuer
  N
  3489
  03/31/2024
  Compensation
  Common
  10/20/2023
  Stock Option Exercise
  Issuer
  N
  45500
  10/20/2023
  Cash
  Common
  12/30/2022
  Stock Option Exercise
  Issuer
  N
  4500
  12/30/2022
  Cash
  Common
  10/14/2024
  Stock Option Exercise
  Issuer
  N
  41754
  10/14/2024
  Cash
  Y
  Some of the shares covered by this filing are stock options that will be exercised within three months from the date of this filing. Sales that were executed on October 14, 2024  are being reported on this Form 144 filed today given the EDGAR system was not accepting filings on October 14, 2024 in observance of the federal holiday.
  10/15/2024
  06/28/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Giuseppe Ciaramella