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        <filer>
          <filerCredentials>
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            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001581280</issuerCik>
        <issuerName>Twist Bioscience Corp</issuerName>
        <secFileNumber>001-38720</secFileNumber>
        <issuerAddress>
          <com:street1>681 GATEWAY BLVD.</com:street1>
          <com:city>SOUTH SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>800-719-0671</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Laponis Adam</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>556</noOfUnitsSold>
        <aggregateMarketValue>18434.35</aggregateMarketValue>
        <noOfUnitsOutstanding>57818022</noOfUnitsOutstanding>
        <approxSaleDate>04/09/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/08/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>556</amountOfSecuritiesAcquired>
        <paymentDate>04/08/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>04/09/2024</noticeDate>
        <signature>/s/ Jennifer Ruchti, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Adam Laponis</signature>
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text: 144
  0001827198
  XXXXXXXX
  LIVE
  0001581280
  Twist Bioscience Corp
  001-38720
  681 GATEWAY BLVD.
  SOUTH SAN FRANCISCO
  CA
  94080
  800-719-0671
  Laponis Adam
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  556
  18434.35
  57818022
  04/09/2024
  NASDAQ
  Common
  04/08/2024
  Restricted Stock Vesting
  Issuer
  N
  556
  04/08/2024
  Compensation
  Y
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  04/09/2024
  /s/ Jennifer Ruchti, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Adam Laponis