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      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001635324</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001447028</issuerCik>
        <issuerName>Arbutus Biopharma Corp</issuerName>
        <secFileNumber>001-34949</secFileNumber>
        <issuerAddress>
          <com:street1>701 VETERANS CIRCLE</com:street1>
          <com:city>WARMINSTER</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>18974</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>604-419-3200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sofia Michael J.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Member of immediate family of any of the foregoing</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>167162</noOfUnitsSold>
        <aggregateMarketValue>549962.98</aggregateMarketValue>
        <noOfUnitsOutstanding>189490000</noOfUnitsOutstanding>
        <approxSaleDate>03/07/2025</approxSaleDate>
        <securitiesExchangeName>nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/26/2012</acquiredDate>
        <natureOfAcquisitionTransaction>Gift</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Michael Sofia</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>70706</amountOfSecuritiesAcquired>
        <paymentDate>09/26/2012</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/26/2012</acquiredDate>
        <natureOfAcquisitionTransaction>Gift</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Michael sofia</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>96456</amountOfSecuritiesAcquired>
        <paymentDate>09/26/2012</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>shares are bieng sold from
  96,456 IRRVOC DEED OF TR OF MICHAEL J SOFIA, U/A 7/6/20 FBO Michelle
  70,706 IRRVOC DEED OF TR OF MICHAEL J SOFIA, U/A 7/6/20 FBO Jacqueline</remarks>
      <noticeSignature>
        <noticeDate>03/07/2025</noticeDate>
        <signature>/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Michael J. Sofia</signature>
      </noticeSignature>
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text: 144
  0001635324
  XXXXXXXX
  LIVE
  0001447028
  Arbutus Biopharma Corp
  001-34949
  701 VETERANS CIRCLE
  WARMINSTER
  PA
  18974
  604-419-3200
  Sofia Michael J.
  Member of immediate family of any of the foregoing
  Common Stock
  Fidelity Brokerage Services LLC
  245 Summer Street
  Boston
  MA
  02110
  167162
  549962.98
  189490000
  03/07/2025
  nasdaq
  Common
  09/26/2012
  Gift
  Michael Sofia
  N
  70706
  09/26/2012
  N/A
  Common
  09/26/2012
  Gift
  Michael sofia
  N
  96456
  09/26/2012
  N/A
  Y
  shares are bieng sold from
  96,456 IRRVOC DEED OF TR OF MICHAEL J SOFIA, U/A 7/6/20 FBO Michelle
  70,706 IRRVOC DEED OF TR OF MICHAEL J SOFIA, U/A 7/6/20 FBO Jacqueline
  03/07/2025
  /s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Michael J. Sofia