content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001960954</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000039263</issuerCik>
        <issuerName>CULLEN/FROST BANKERS, INC.</issuerName>
        <secFileNumber>001-13221</secFileNumber>
        <issuerAddress>
          <com:street1>111 W HOUSTON ST</com:street1>
          <com:city>SAN ANTONIO</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78205</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>210-220-4011</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kasanoff Howard L.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>FIDELITY BROKERAGE SERVICES LLC </name>
          <address>
            <com:street1>245 SUMMER STREET</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>4000</noOfUnitsSold>
        <aggregateMarketValue>574640.00</aggregateMarketValue>
        <noOfUnitsOutstanding>64131862</noOfUnitsOutstanding>
        <approxSaleDate>11/08/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/27/2015</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4000</amountOfSecuritiesAcquired>
        <paymentDate>10/27/2015</paymentDate>
        <natureOfPayment>Cash/Check</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/08/2024</noticeDate>
        <signature>/s/ Daniel Gardea as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Kasanoff Howard L.</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2835}]
text: 144
  0001960954
  XXXXXXXX
  LIVE
  0000039263
  CULLEN/FROST BANKERS, INC.
  001-13221
  111 W HOUSTON ST
  SAN ANTONIO
  TX
  78205
  210-220-4011
  Kasanoff Howard L.
  Officer
  Common
  FIDELITY BROKERAGE SERVICES LLC
  245 SUMMER STREET
  Boston
  MA
  02110
  4000
  574640.00
  64131862
  11/08/2024
  NYSE
  Common
  10/27/2015
  Stock Option Exercise
  Issuer
  N
  4000
  10/27/2015
  Cash/Check
  Y
  11/08/2024
  /s/ Daniel Gardea as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Kasanoff Howard L.