content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001772124</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001446847</issuerCik>
        <issuerName>IRONWOOD PHARMACEUTICALS INC</issuerName>
        <secFileNumber>001-34620</secFileNumber>
        <issuerAddress>
          <com:street1>100 SUMMER STREET, SUITE 2300</com:street1>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-621-7722</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kessler Marla L</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A common stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>9926</noOfUnitsSold>
        <aggregateMarketValue>111071.94</aggregateMarketValue>
        <noOfUnitsOutstanding>156129046</noOfUnitsOutstanding>
        <approxSaleDate>12/14/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A common stock</securitiesClassTitle>
        <acquiredDate>06/19/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vest</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Ironwood Pharmaceuticals, Inc.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>9926</amountOfSecuritiesAcquired>
        <paymentDate>06/19/2023</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/14/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>09/06/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Myra King, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Marla Kessler</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001772124
  XXXXXXXX
  LIVE
  0001446847
  IRONWOOD PHARMACEUTICALS INC
  001-34620
  100 SUMMER STREET, SUITE 2300
  BOSTON
  MA
  02110
  617-621-7722
  Kessler Marla L
  Director
  Class A common stock
  Fidelity Brokerage Services LLC
  245 Summer Street
  Boston
  MA
  02110
  9926
  111071.94
  156129046
  12/14/2023
  NASDAQ
  Class A common stock
  06/19/2023
  Restricted Stock Vest
  Ironwood Pharmaceuticals, Inc.
  N
  9926
  06/19/2023
  N/A
  Y
  12/14/2023
  09/06/2023
  /s/ Myra King, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Marla Kessler