content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001766524</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001434868</issuerCik>
        <issuerName>Esperion Therapeutics, Inc.</issuerName>
        <secFileNumber>001-35986</secFileNumber>
        <issuerAddress>
          <com:street1>3891 RANCHERO DRIVE, SUITE 150</com:street1>
          <com:city>ANN ARBOR</com:city>
          <com:stateOrCountry>MI</com:stateOrCountry>
          <com:zipCode>48108</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>734-887-3903</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Koenig Sheldon L.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>12447</noOfUnitsSold>
        <aggregateMarketValue>30698.04</aggregateMarketValue>
        <noOfUnitsOutstanding>197035171</noOfUnitsOutstanding>
        <approxSaleDate>12/17/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/16/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>12447</amountOfSecuritiesAcquired>
        <paymentDate>12/16/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Sheldon Koenig</name>
          <address>
            <com:street1>3891 Ranchero Drive</com:street1>
            <com:street2>Suite 150</com:street2>
            <com:city>Ann Arbor</com:city>
            <com:stateOrCountry>MI</com:stateOrCountry>
            <com:zipCode>48108</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/17/2024</saleDate>
        <amountOfSecuritiesSold>14550</amountOfSecuritiesSold>
        <grossProceeds>26133.24</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>12/17/2024</noticeDate>
        <signature>/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Sheldon Koenig</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3701}]
text: 144
  0001766524
  XXXXXXXX
  LIVE
  0001434868
  Esperion Therapeutics, Inc.
  001-35986
  3891 RANCHERO DRIVE, SUITE 150
  ANN ARBOR
  MI
  48108
  734-887-3903
  Koenig Sheldon L.
  Officer
  Director
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  12447
  30698.04
  197035171
  12/17/2024
  NASDAQ
  Common
  12/16/2024
  Restricted Stock Vesting
  Issuer
  N
  12447
  12/16/2024
  Compensation
  N
  Sheldon Koenig
  3891 Ranchero Drive
  Suite 150
  Ann Arbor
  MI
  48108
  Common
  09/17/2024
  14550
  26133.24
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  12/17/2024
  /s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Sheldon Koenig