content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001382297</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000927653</issuerCik>
        <issuerName>MCKESSON CORP</issuerName>
        <secFileNumber>001-13252</secFileNumber>
        <issuerAddress>
          <com:street1>6555 STATE HIGHWAY 161</com:street1>
          <com:city>IRVING</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75039</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>972-446-4800</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>TYLER BRIAN S.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3753</noOfUnitsSold>
        <aggregateMarketValue>2155760.73</aggregateMarketValue>
        <noOfUnitsOutstanding>129985514</noOfUnitsOutstanding>
        <approxSaleDate>06/05/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/21/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3753</amountOfSecuritiesAcquired>
        <paymentDate>05/21/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Brian Tyler</name>
          <address>
            <com:street1>6555 State Hwy 161</com:street1>
            <com:city>Irving</com:city>
            <com:stateOrCountry>TX</com:stateOrCountry>
            <com:zipCode>75039</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>03/15/2024</saleDate>
        <amountOfSecuritiesSold>3473</amountOfSecuritiesSold>
        <grossProceeds>1821762.15</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>06/05/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>12/02/2022</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Brian S. Tyler</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001382297
  XXXXXXXX
  LIVE
  0000927653
  MCKESSON CORP
  001-13252
  6555 STATE HIGHWAY 161
  IRVING
  TX
  75039
  972-446-4800
  TYLER BRIAN S.
  Officer
  Director
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  3753
  2155760.73
  129985514
  06/05/2024
  NYSE
  Common
  05/21/2024
  Restricted Stock Vesting
  Issuer
  N
  3753
  05/21/2024
  Compensation
  N
  Brian Tyler
  6555 State Hwy 161
  Irving
  TX
  75039
  Common
  03/15/2024
  3473
  1821762.15
  06/05/2024
  12/02/2022
  /s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Brian S. Tyler