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            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001590750</issuerCik>
        <issuerName>Viridian Therapeutics, Inc.\DE</issuerName>
        <secFileNumber>001-36483</secFileNumber>
        <issuerAddress>
          <com:street1>221 CRESCENT STREET</com:street1>
          <com:street2>BLDG. 17, SUITE 401</com:street2>
          <com:city>WALTHAM</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02453</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617.272.4600</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Myers Scott Dunseth</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Officer and Director</relationshipToIssuer>
        </relationshipsToIssuer>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>35368</noOfUnitsSold>
        <aggregateMarketValue>535117.84</aggregateMarketValue>
        <noOfUnitsOutstanding>52586039</noOfUnitsOutstanding>
        <approxSaleDate>11/16/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/27/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>35368</amountOfSecuritiesAcquired>
        <paymentDate>10/27/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/16/2023</noticeDate>
        <signature>/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Scott D. Myers</signature>
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text: 144
  0001356256
  XXXXXXXX
  LIVE
  0001590750
  Viridian Therapeutics, Inc.\DE
  001-36483
  221 CRESCENT STREET
  BLDG. 17, SUITE 401
  WALTHAM
  MA
  02453
  617.272.4600
  Myers Scott Dunseth
  Former Officer and Director
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  35368
  535117.84
  52586039
  11/16/2023
  NASDAQ
  Common
  10/27/2023
  Restricted Stock Vesting
  Issuer
  N
  35368
  10/27/2023
  Compensation
  Y
  11/16/2023
  /s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Scott D. Myers