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          <filerCredentials>
            <cik>0001190636</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001609550</issuerCik>
        <issuerName>Inspire Medical Systems, Inc.</issuerName>
        <secFileNumber>001-38468</secFileNumber>
        <issuerAddress>
          <com:street1>5500 WAYZATA BLVD</com:street1>
          <com:street2>SUITE 1600</com:street2>
          <com:city>GOLDEN VALLEY</com:city>
          <com:stateOrCountry>MN</com:stateOrCountry>
          <com:zipCode>55416</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>763-957-5037</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KRAUSZ STEVEN M</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>General Partner/Venture Investor</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Merrill Lynch</name>
          <address>
            <com:street1>555 California St</com:street1>
            <com:street2>Floor 18</com:street2>
            <com:city>San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94104</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1961</noOfUnitsSold>
        <aggregateMarketValue>288000.00</aggregateMarketValue>
        <noOfUnitsOutstanding>29524189</noOfUnitsOutstanding>
        <approxSaleDate>12/01/2023</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/15/2014</acquiredDate>
        <natureOfAcquisitionTransaction>Private Placement</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Krausz Family Trust</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1961</amountOfSecuritiesAcquired>
        <paymentDate>04/15/2014</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/01/2023</noticeDate>
        <signature>Steven M Krausz</signature>
      </noticeSignature>
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text: 144
  0001190636
  XXXXXXXX
  LIVE
  0001609550
  Inspire Medical Systems, Inc.
  001-38468
  5500 WAYZATA BLVD
  SUITE 1600
  GOLDEN VALLEY
  MN
  55416
  763-957-5037
  KRAUSZ STEVEN M
  General Partner/Venture Investor
  Common
  Merrill Lynch
  555 California St
  Floor 18
  San Francisco
  CA
  94104
  1961
  288000.00
  29524189
  12/01/2023
  NYSE
  Common
  04/15/2014
  Private Placement
  Krausz Family Trust
  N
  1961
  04/15/2014
  Cash
  Y
  12/01/2023
  Steven M Krausz