content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001635324</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
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    <formData>
      <issuerInfo>
        <issuerCik>0001447028</issuerCik>
        <issuerName>Arbutus Biopharma Corp</issuerName>
        <secFileNumber>001-34949</secFileNumber>
        <issuerAddress>
          <com:street1>701 VETERANS CIRCLE</com:street1>
          <com:city>WARMINSTER</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>18974</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>604-419-3200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sofia Michael J.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>100000</noOfUnitsSold>
        <aggregateMarketValue>338000.00</aggregateMarketValue>
        <noOfUnitsOutstanding>189490000</noOfUnitsOutstanding>
        <approxSaleDate>03/13/2025</approxSaleDate>
        <securitiesExchangeName>nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/26/2012</acquiredDate>
        <natureOfAcquisitionTransaction>Merger Acquisition</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ABUS</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>100000</amountOfSecuritiesAcquired>
        <paymentDate>09/26/2012</paymentDate>
        <natureOfPayment>Cash/Check</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Michael Sofia c/o Arbutus Biopharma Corp</name>
          <address>
            <com:street1>701 VETERANS CIRCLE</com:street1>
            <com:city>WARMINSTER</com:city>
            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>18974</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>03/07/2025</saleDate>
        <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
        <grossProceeds>33600.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Michael Sofia c/o Arbutus Biopharma Corp</name>
          <address>
            <com:street1>701 VETERANS CIRCLE,</com:street1>
            <com:city>WARMINSTER</com:city>
            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>18974</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>03/11/2025</saleDate>
        <amountOfSecuritiesSold>157162</amountOfSecuritiesSold>
        <grossProceeds>481270.92</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>03/13/2025</noticeDate>
        <signature>/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Michael J. Sofia</signature>
      </noticeSignature>
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text: 144
  0001635324
  XXXXXXXX
  LIVE
  0001447028
  Arbutus Biopharma Corp
  001-34949
  701 VETERANS CIRCLE
  WARMINSTER
  PA
  18974
  604-419-3200
  Sofia Michael J.
  Officer
  Common Stock
  Fidelity Brokerage Services LLC
  245 Summer Street
  Boston
  MA
  02110
  100000
  338000.00
  189490000
  03/13/2025
  nasdaq
  Common
  09/26/2012
  Merger Acquisition
  ABUS
  N
  100000
  09/26/2012
  Cash/Check
  N
  Michael Sofia c/o Arbutus Biopharma Corp
  701 VETERANS CIRCLE
  WARMINSTER
  PA
  18974
  Common
  03/07/2025
  10000
  33600.00
  Michael Sofia c/o Arbutus Biopharma Corp
  701 VETERANS CIRCLE,
  WARMINSTER
  PA
  18974
  Common
  03/11/2025
  157162
  481270.92
  03/13/2025
  /s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Michael J. Sofia