content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001526287</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000889331</issuerCik>
        <issuerName>LITTELFUSE INC /DE</issuerName>
        <secFileNumber>000-20388</secFileNumber>
        <issuerAddress>
          <com:street1>8755 WEST HIGGINS ROAD</com:street1>
          <com:city>CHICAGO</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60631</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>773-628-1000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Nayar Deepak</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Merrill Lynch</name>
          <address>
            <com:street1>8890 Lyra Drive</com:street1>
            <com:street2>5th Floor</com:street2>
            <com:city>Columbus</com:city>
            <com:stateOrCountry>OH</com:stateOrCountry>
            <com:zipCode>43240</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>6792</noOfUnitsSold>
        <aggregateMarketValue>1762811.00</aggregateMarketValue>
        <noOfUnitsOutstanding>24831600</noOfUnitsOutstanding>
        <approxSaleDate>05/08/2023</approxSaleDate>
        <securitiesExchangeName>nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/23/2020</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Littlefuse, Inc</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3573</amountOfSecuritiesAcquired>
        <paymentDate>05/08/2023</paymentDate>
        <natureOfPayment>cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/22/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Littlefuse, Inc</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>323</amountOfSecuritiesAcquired>
        <paymentDate>04/22/2023</paymentDate>
        <natureOfPayment>n/a</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/23/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Littlefuse, Inc</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2511</amountOfSecuritiesAcquired>
        <paymentDate>04/23/2023</paymentDate>
        <natureOfPayment>n/a</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/28/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Littlefuse, Inc</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>385</amountOfSecuritiesAcquired>
        <paymentDate>04/28/2023</paymentDate>
        <natureOfPayment>n/a</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/08/2023</noticeDate>
        <signature>Deepak Nayar</signature>
      </noticeSignature>
    </formData>
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metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4344}]
text: 144
  0001526287
  XXXXXXXX
  LIVE
  0000889331
  LITTELFUSE INC /DE
  000-20388
  8755 WEST HIGGINS ROAD
  CHICAGO
  IL
  60631
  773-628-1000
  Nayar Deepak
  Officer
  Common
  Merrill Lynch
  8890 Lyra Drive
  5th Floor
  Columbus
  OH
  43240
  6792
  1762811.00
  24831600
  05/08/2023
  nasdaq
  Common
  04/23/2020
  Stock Option Exercise
  Littlefuse, Inc
  N
  3573
  05/08/2023
  cash
  Common
  04/22/2023
  Restricted Stock Lapse
  Littlefuse, Inc
  N
  323
  04/22/2023
  n/a
  Common
  04/23/2023
  Restricted Stock Lapse
  Littlefuse, Inc
  N
  2511
  04/23/2023
  n/a
  Common
  04/28/2023
  Restricted Stock Lapse
  Littlefuse, Inc
  N
  385
  04/28/2023
  n/a
  Y
  05/08/2023
  Deepak Nayar