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        <filer>
          <filerCredentials>
            <cik>0001539494</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001356576</issuerCik>
        <issuerName>SUPERNUS PHARMACEUTICALS, INC.</issuerName>
        <secFileNumber>001-35518</secFileNumber>
        <issuerAddress>
          <com:street1>9715 KEY WEST AVENUE</com:street1>
          <com:city>ROCKVILLE</com:city>
          <com:stateOrCountry>MD</com:stateOrCountry>
          <com:zipCode>20850</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>301-838-2500</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Martin Tami Tillotson</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Morgan Stanley Smith Barney</name>
          <address>
            <com:street1>One New York Plaza</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10004</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>5000</noOfUnitsSold>
        <aggregateMarketValue>142700.00</aggregateMarketValue>
        <noOfUnitsOutstanding>54974254</noOfUnitsOutstanding>
        <approxSaleDate>06/25/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/25/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
        <paymentDate>06/25/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>07/16/2024</noticeDate>
        <signature>/s/ Tami Tillotson Martin</signature>
      </noticeSignature>
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text: 144
  0001539494
  XXXXXXXX
  LIVE
  0001356576
  SUPERNUS PHARMACEUTICALS, INC.
  001-35518
  9715 KEY WEST AVENUE
  ROCKVILLE
  MD
  20850
  301-838-2500
  Martin Tami Tillotson
  Former Officer
  Common
  Morgan Stanley Smith Barney
  One New York Plaza
  New York
  NY
  10004
  5000
  142700.00
  54974254
  06/25/2024
  NASDAQ
  Common
  06/25/2024
  Exercise of options under a registered plan
  Issuer
  N
  5000
  06/25/2024
  Cash
  Y
  07/16/2024
  /s/ Tami Tillotson Martin