content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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        <filer>
          <filerCredentials>
            <cik>0001251708</cik>
            <ccc>XXXXXXXX</ccc>
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        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
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      <issuerInfo>
        <issuerCik>0000103145</issuerCik>
        <issuerName>Veeco Instruments, Inc.</issuerName>
        <secFileNumber>000-16244</secFileNumber>
        <issuerAddress>
          <com:street1>1 Terminal Drive</com:street1>
          <com:city>Plainview</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>11803</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>516-677-0200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>John Kiernan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>30000</noOfUnitsSold>
        <aggregateMarketValue>900000</aggregateMarketValue>
        <noOfUnitsOutstanding>56341738</noOfUnitsOutstanding>
        <approxSaleDate>11/27/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/14/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>980</amountOfSecuritiesAcquired>
        <paymentDate>06/14/2017</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/12/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>688</amountOfSecuritiesAcquired>
        <paymentDate>06/12/2017</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/12/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>264</amountOfSecuritiesAcquired>
        <paymentDate>06/12/2017</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/18/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>8272</amountOfSecuritiesAcquired>
        <paymentDate>03/18/2022</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/17/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>786</amountOfSecuritiesAcquired>
        <paymentDate>03/17/2022</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/10/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1258</amountOfSecuritiesAcquired>
        <paymentDate>07/10/2017</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/14/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>529</amountOfSecuritiesAcquired>
        <paymentDate>03/14/2022</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/12/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2044</amountOfSecuritiesAcquired>
        <paymentDate>03/12/2022</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/13/2016</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4883</amountOfSecuritiesAcquired>
        <paymentDate>12/13/2016</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/16/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>448</amountOfSecuritiesAcquired>
        <paymentDate>06/16/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/02/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1272</amountOfSecuritiesAcquired>
        <paymentDate>07/02/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/04/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1299</amountOfSecuritiesAcquired>
        <paymentDate>05/04/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/04/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>933</amountOfSecuritiesAcquired>
        <paymentDate>05/04/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/14/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>526</amountOfSecuritiesAcquired>
        <paymentDate>09/14/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/14/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>551</amountOfSecuritiesAcquired>
        <paymentDate>09/14/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/17/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>714</amountOfSecuritiesAcquired>
        <paymentDate>03/17/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/12/2016</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>183</amountOfSecuritiesAcquired>
        <paymentDate>06/12/2016</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/13/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4370</amountOfSecuritiesAcquired>
        <paymentDate>12/13/2017</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/27/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>08/22/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for John Kiernan</signature>
      </noticeSignature>
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metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 11864}]
text: 144
  0001251708
  XXXXXXXX
  LIVE
  0000103145
  Veeco Instruments, Inc.
  000-16244
  1 Terminal Drive
  Plainview
  NY
  11803
  516-677-0200
  John Kiernan
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  30000
  900000
  56341738
  11/27/2023
  NASDAQ
  Common
  06/14/2017
  Restricted Stock Award
  Issuer
  N
  980
  06/14/2017
  N/A
  Common
  06/12/2017
  Restricted Stock Award
  Issuer
  N
  688
  06/12/2017
  N/A
  Common
  06/12/2017
  Restricted Stock Award
  Issuer
  N
  264
  06/12/2017
  N/A
  Common
  03/18/2022
  Restricted Stock Award
  Issuer
  N
  8272
  03/18/2022
  N/A
  Common
  03/17/2022
  Restricted Stock Award
  Issuer
  N
  786
  03/17/2022
  N/A
  Common
  07/10/2017
  Restricted Stock Award
  Issuer
  N
  1258
  07/10/2017
  N/A
  Common
  03/14/2022
  Restricted Stock Award
  Issuer
  N
  529
  03/14/2022
  N/A
  Common
  03/12/2022
  Restricted Stock Award
  Issuer
  N
  2044
  03/12/2022
  N/A
  Common
  12/13/2016
  Restricted Stock Award
  Issuer
  N
  4883
  12/13/2016
  N/A
  Common
  06/16/2021
  Restricted Stock Award
  Issuer
  N
  448
  06/16/2021
  N/A
  Common
  07/02/2021
  Restricted Stock Award
  Issuer
  N
  1272
  07/02/2021
  N/A
  Common
  05/04/2021
  Restricted Stock Award
  Issuer
  N
  1299
  05/04/2021
  N/A
  Common
  05/04/2021
  Restricted Stock Award
  Issuer
  N
  933
  05/04/2021
  N/A
  Common
  09/14/2021
  Restricted Stock Award
  Issuer
  N
  526
  09/14/2021
  N/A
  Common
  09/14/2021
  Restricted Stock Award
  Issuer
  N
  551
  09/14/2021
  N/A
  Common
  03/17/2021
  Restricted Stock Award
  Issuer
  N
  714
  03/17/2021
  N/A
  Common
  06/12/2016
  Restricted Stock Award
  Issuer
  N
  183
  06/12/2016
  N/A
  Common
  12/13/2017
  Restricted Stock Award
  Issuer
  N
  4370
  12/13/2017
  N/A
  Y
  11/27/2023
  08/22/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for John Kiernan