content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001779978</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001679363</issuerCik>
        <issuerName>Morphic Holdings Inc.</issuerName>
        <secFileNumber>001-38940</secFileNumber>
        <issuerAddress>
          <com:street1>35 GATEHOUSE DRIVE, A2</com:street1>
          <com:city>WALTHAM</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>7819960955</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Praveen R. Tipirneni</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>64746</noOfUnitsSold>
        <aggregateMarketValue>3561030</aggregateMarketValue>
        <noOfUnitsOutstanding>50093588</noOfUnitsOutstanding>
        <approxSaleDate>07/08/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/08/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>64746</amountOfSecuritiesAcquired>
        <paymentDate>07/08/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The sales under this filing are from Cashless Option Exercises that will occur within 3 months from the date of this filing.</remarks>
      <noticeSignature>
        <noticeDate>07/08/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>12/27/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Praveen R. Tipirneni</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3115}]
text: 144
  0001779978
  XXXXXXXX
  LIVE
  0001679363
  Morphic Holdings Inc.
  001-38940
  35 GATEHOUSE DRIVE, A2
  WALTHAM
  MA
  02451
  7819960955
  Praveen R. Tipirneni
  Officer
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  64746
  3561030
  50093588
  07/08/2024
  Nasdaq
  Common
  07/08/2024
  Stock Option Exercise
  Issuer
  N
  64746
  07/08/2024
  Cash
  Y
  The sales under this filing are from Cashless Option Exercises that will occur within 3 months from the date of this filing.
  07/08/2024
  12/27/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Praveen R. Tipirneni