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        <filer>
          <filerCredentials>
            <cik>0001883804</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
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    <formData>
      <issuerInfo>
        <issuerCik>0001556263</issuerCik>
        <issuerName>Syros Pharmaceuticals, Inc.</issuerName>
        <secFileNumber>001-37813</secFileNumber>
        <issuerAddress>
          <com:street1>35 CAMBRIDGE PARK DRIVE</com:street1>
          <com:city>CAMBRIDGE</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02140</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-744-1340</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Chee Conley</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>100000</noOfUnitsSold>
        <aggregateMarketValue>25930.00</aggregateMarketValue>
        <noOfUnitsOutstanding>26832457</noOfUnitsOutstanding>
        <approxSaleDate>11/18/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/10/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Buy</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
        <paymentDate>09/10/2024</paymentDate>
        <natureOfPayment>Cash/Check</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/11/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Buy</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
        <paymentDate>09/11/2024</paymentDate>
        <natureOfPayment>Cash/Check</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Conley Chee</name>
          <address>
            <com:street1>35 Cambridgepark Drive, 4th FLoor</com:street1>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02140</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Syros Pharmaceuticals, Inc.</securitiesClassTitle>
        <saleDate>11/01/2024</saleDate>
        <amountOfSecuritiesSold>8707</amountOfSecuritiesSold>
        <grossProceeds>18211.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/18/2024</noticeDate>
        <signature>/s/ Heather Foxworth as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Chee Conley</signature>
      </noticeSignature>
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text: 144
  0001883804
  XXXXXXXX
  LIVE
  0001556263
  Syros Pharmaceuticals, Inc.
  001-37813
  35 CAMBRIDGE PARK DRIVE
  CAMBRIDGE
  MA
  02140
  617-744-1340
  Chee Conley
  Officer
  Common
  Fidelity Brokerage Services LLC
  245 Summer Street
  Boston
  MA
  02110
  100000
  25930.00
  26832457
  11/18/2024
  NASDAQ
  Common
  09/10/2024
  Open Market Buy
  Open Market
  N
  50000
  09/10/2024
  Cash/Check
  Common
  09/11/2024
  Open Market Buy
  Open Market
  N
  50000
  09/11/2024
  Cash/Check
  N
  Conley Chee
  35 Cambridgepark Drive, 4th FLoor
  Cambridge
  MA
  02140
  Syros Pharmaceuticals, Inc.
  11/01/2024
  8707
  18211.00
  11/18/2024
  /s/ Heather Foxworth as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Chee Conley