content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001890578</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001676725</issuerCik>
        <issuerName>IDEAYA Biosciences, Inc.</issuerName>
        <secFileNumber>001-38915</secFileNumber>
        <issuerAddress>
          <com:street1>7000 Shoreline Court</com:street1>
          <com:street2>Suite 350</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>6504436209</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Michael White</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>28500</noOfUnitsSold>
        <aggregateMarketValue>1054500</aggregateMarketValue>
        <noOfUnitsOutstanding>75686628</noOfUnitsOutstanding>
        <approxSaleDate>05/29/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/29/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>28500</amountOfSecuritiesAcquired>
        <paymentDate>05/29/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The sales under this filing  will include Cashless Option Exercises that will occur within 3 months from the date of this filing.</remarks>
      <noticeSignature>
        <noticeDate>05/29/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>02/22/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Michael White</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001890578
  XXXXXXXX
  LIVE
  0001676725
  IDEAYA Biosciences, Inc.
  001-38915
  7000 Shoreline Court
  Suite 350
  San Francisco
  CA
  94080
  6504436209
  Michael White
  Officer
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  28500
  1054500
  75686628
  05/29/2024
  Nasdaq
  Common
  05/29/2024
  Stock Option Exercise
  Issuer
  N
  28500
  05/29/2024
  Cash
  Y
  The sales under this filing  will include Cashless Option Exercises that will occur within 3 months from the date of this filing.
  05/29/2024
  02/22/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Michael White