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        <issuerName>Pacira BioSciences, Inc.</issuerName>
        <secFileNumber>001-35060</secFileNumber>
        <issuerAddress>
          <com:street1>5401 WEST KENNEDY BOULEVARD</com:street1>
          <com:street2>SUITE 890</com:street2>
          <com:city>TAMPA</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33609</com:zipCode>
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        <issuerContactPhone>813-553-6680</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>WINSTON ROY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Officer</relationshipToIssuer>
        </relationshipsToIssuer>
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        <brokerOrMarketmakerDetails>
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          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
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        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
        <paymentDate>11/04/2021</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/03/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
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        <amountOfSecuritiesAcquired>6113</amountOfSecuritiesAcquired>
        <paymentDate>06/03/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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        <paymentDate>06/30/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/01/2022</acquiredDate>
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        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>774</amountOfSecuritiesAcquired>
        <paymentDate>08/01/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/05/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
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        <amountOfSecuritiesAcquired>2784</amountOfSecuritiesAcquired>
        <paymentDate>06/05/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/06/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2705</amountOfSecuritiesAcquired>
        <paymentDate>06/06/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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        <paymentDate>06/30/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/01/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>741</amountOfSecuritiesAcquired>
        <paymentDate>08/01/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/24/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6411</amountOfSecuritiesAcquired>
        <paymentDate>10/24/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/13/2023</noticeDate>
        <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Roy S Winston</signature>
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text: 144
  0001751757
  XXXXXXXX
  LIVE
  0001396814
  Pacira BioSciences, Inc.
  001-35060
  5401 WEST KENNEDY BOULEVARD
  SUITE 890
  TAMPA
  FL
  33609
  813-553-6680
  WINSTON ROY
  Former Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  31000
  875858.04
  46437704
  11/10/2023
  NASDAQ
  Common
  06/30/2021
  ESPP Purchase
  Issuer
  N
  421
  06/30/2021
  Cash
  Common
  11/04/2021
  Stock Option Exercise
  Issuer
  N
  10000
  11/04/2021
  Cash
  Common
  06/03/2022
  Restricted Stock Vesting
  Issuer
  N
  6113
  06/03/2022
  Compensation
  Common
  06/30/2022
  ESPP Purchase
  Issuer
  N
  408
  06/30/2022
  Cash
  Common
  08/01/2022
  Restricted Stock Vesting
  Issuer
  N
  774
  08/01/2022
  Compensation
  Common
  06/05/2023
  Restricted Stock Vesting
  Issuer
  N
  2784
  06/05/2023
  Compensation
  Common
  06/06/2023
  Restricted Stock Vesting
  Issuer
  N
  2705
  06/06/2023
  Compensation
  Common
  06/30/2023
  ESPP Purchase
  Issuer
  N
  643
  06/30/2023
  Cash
  Common
  08/01/2023
  Restricted Stock Vesting
  Issuer
  N
  741
  08/01/2023
  Compensation
  Common
  10/24/2023
  Restricted Stock Vesting
  Issuer
  N
  6411
  10/24/2023
  Compensation
  Y
  11/13/2023
  /s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Roy S Winston