content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001868741</cik>
            <ccc>XXXXXXXX</ccc>
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        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001861560</issuerCik>
        <issuerName>Nuvalent, Inc.</issuerName>
        <secFileNumber>001-40671</secFileNumber>
        <issuerAddress>
          <com:street1>One Broadway, 14th floor</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>8573577000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Deborah Ann Miller</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>13500</noOfUnitsSold>
        <aggregateMarketValue>654750</aggregateMarketValue>
        <noOfUnitsOutstanding>51385516</noOfUnitsOutstanding>
        <approxSaleDate>07/28/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <acquiredDate>07/28/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>13500</amountOfSecuritiesAcquired>
        <paymentDate>07/28/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Deborah Miller</name>
          <address>
            <com:street1>One Broadway, 14th floor</com:street1>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>05/01/2023</saleDate>
        <amountOfSecuritiesSold>900</amountOfSecuritiesSold>
        <grossProceeds>35648</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Deborah Miller</name>
          <address>
            <com:street1>One Broadway, 14th floor</com:street1>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>05/05/2023</saleDate>
        <amountOfSecuritiesSold>2800</amountOfSecuritiesSold>
        <grossProceeds>110991</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Deborah Miller</name>
          <address>
            <com:street1>One Broadway, 14th floor</com:street1>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>05/09/2023</saleDate>
        <amountOfSecuritiesSold>1332</amountOfSecuritiesSold>
        <grossProceeds>52788</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Deborah Miller</name>
          <address>
            <com:street1>One Broadway, 14th floor</com:street1>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>05/15/2023</saleDate>
        <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
        <grossProceeds>81495</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Deborah Miller</name>
          <address>
            <com:street1>One Broadway, 14th floor</com:street1>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>06/15/2023</saleDate>
        <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
        <grossProceeds>88570</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Deborah Miller</name>
          <address>
            <com:street1>One Broadway, 14th floor</com:street1>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>07/17/2023</saleDate>
        <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
        <grossProceeds>86117</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>07/28/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>10/22/2021</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Deborah Ann Miller</signature>
      </noticeSignature>
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text: 144
  0001868741
  XXXXXXXX
  LIVE
  0001861560
  Nuvalent, Inc.
  001-40671
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  8573577000
  Deborah Ann Miller
  Officer
  Class A Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  13500
  654750
  51385516
  07/28/2023
  Nasdaq
  Class A Common
  07/28/2023
  Stock Option Exercise
  Issuer
  N
  13500
  07/28/2023
  Cash
  N
  Deborah Miller
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  05/01/2023
  900
  35648
  Deborah Miller
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  05/05/2023
  2800
  110991
  Deborah Miller
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  05/09/2023
  1332
  52788
  Deborah Miller
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  05/15/2023
  2000
  81495
  Deborah Miller
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  06/15/2023
  2000
  88570
  Deborah Miller
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  07/17/2023
  2000
  86117
  07/28/2023
  10/22/2021
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Deborah Ann Miller