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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001731790</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
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        <issuerCik>0001704292</issuerCik>
        <issuerName>Zai Lab Ltd</issuerName>
        <secFileNumber>001-38205</secFileNumber>
        <issuerAddress>
          <com:street1>4560 JINKE ROAD</com:street1>
          <com:street2>BLDG. 1, 4F, PUDONG</com:street2>
          <com:city>SHANGHAI</com:city>
          <com:stateOrCountry>F4</com:stateOrCountry>
          <com:zipCode>201210</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>862161632588</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Du Ying</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>50000</noOfUnitsSold>
        <aggregateMarketValue>1454500.00</aggregateMarketValue>
        <noOfUnitsOutstanding>486853250</noOfUnitsOutstanding>
        <approxSaleDate>05/13/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <acquiredDate>05/13/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted - 10/22/2015</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
        <paymentDate>05/13/2025</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, 4th Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>02/28/2025</saleDate>
        <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
        <grossProceeds>1723465.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, 4th Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>03/03/2025</saleDate>
        <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
        <grossProceeds>1622140.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, 4th Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>03/04/2025</saleDate>
        <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
        <grossProceeds>1674200.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, 4th Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>03/05/2025</saleDate>
        <amountOfSecuritiesSold>46389</amountOfSecuritiesSold>
        <grossProceeds>1649124.31</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, 4th Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>04/02/2025</saleDate>
        <amountOfSecuritiesSold>5808</amountOfSecuritiesSold>
        <grossProceeds>208473.51</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>04/04/2025</saleDate>
        <amountOfSecuritiesSold>2945</amountOfSecuritiesSold>
        <grossProceeds>97504.53</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>05/09/2025</saleDate>
        <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
        <grossProceeds>1481140.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Ying Du</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>05/12/2025</saleDate>
        <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
        <grossProceeds>1472165.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/13/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>11/20/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Jackson Harris, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Ying Du</signature>
      </noticeSignature>
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text: 144
  0001731790
  XXXXXXXX
  LIVE
  0001704292
  Zai Lab Ltd
  001-38205
  4560 JINKE ROAD
  BLDG. 1, 4F, PUDONG
  SHANGHAI
  F4
  201210
  862161632588
  Du Ying
  Officer
  Director
  American Depositary Shares
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  50000
  1454500.00
  486853250
  05/13/2025
  NASDAQ
  American Depositary Shares
  05/13/2025
  Option Granted - 10/22/2015
  Issuer
  N
  50000
  05/13/2025
  Cash
  N
  Ying Du
  4560 Jinke Road
  Bldg. 1, 4th Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  02/28/2025
  50000
  1723465.00
  Ying Du
  4560 Jinke Road
  Bldg. 1, 4th Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  03/03/2025
  50000
  1622140.00
  Ying Du
  4560 Jinke Road
  Bldg. 1, 4th Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  03/04/2025
  50000
  1674200.00
  Ying Du
  4560 Jinke Road
  Bldg. 1, 4th Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  03/05/2025
  46389
  1649124.31
  Ying Du
  4560 Jinke Road
  Bldg. 1, 4th Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  04/02/2025
  5808
  208473.51
  Ying Du
  4560 Jinke Road
  Bldg. 1, Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  04/04/2025
  2945
  97504.53
  Ying Du
  4560 Jinke Road
  Bldg. 1, Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  05/09/2025
  50000
  1481140.00
  Ying Du
  4560 Jinke Road
  Bldg. 1, Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  05/12/2025
  50000
  1472165.00
  05/13/2025
  11/20/2024
  /s/ Jackson Harris, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Ying Du