content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001818522</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001528115</issuerCik>
        <issuerName>Annexon, Inc.</issuerName>
        <secFileNumber>001-39402</secFileNumber>
        <issuerAddress>
          <com:street1>1400 SIERRA POINT PARKWAY</com:street1>
          <com:street2>BLDG C, SUITE 200</com:street2>
          <com:city>BRISBANE</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94005</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(650)-822-5500</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Overdorf Michael</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>784</noOfUnitsSold>
        <aggregateMarketValue>4719.60</aggregateMarketValue>
        <noOfUnitsOutstanding>92412866</noOfUnitsOutstanding>
        <approxSaleDate>07/15/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/11/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>784</amountOfSecuritiesAcquired>
        <paymentDate>07/11/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>07/15/2024</noticeDate>
        <signature>/s/ Gary Redman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Michael Overdorf</signature>
      </noticeSignature>
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text: 144
  0001818522
  XXXXXXXX
  LIVE
  0001528115
  Annexon, Inc.
  001-39402
  1400 SIERRA POINT PARKWAY
  BLDG C, SUITE 200
  BRISBANE
  CA
  94005
  (650)-822-5500
  Overdorf Michael
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  784
  4719.60
  92412866
  07/15/2024
  NASDAQ
  Common
  07/11/2024
  Restricted Stock Vesting
  Issuer
  N
  784
  07/11/2024
  Compensation
  Y
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  07/15/2024
  /s/ Gary Redman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Michael Overdorf