content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001809355</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001627475</issuerCik>
        <issuerName>UPWORK, INC</issuerName>
        <secFileNumber>001-38678</secFileNumber>
        <issuerAddress>
          <com:street1>475 BRANNAN STREET</com:street1>
          <com:street2>SUITE 430</com:street2>
          <com:city>SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94107</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>650-316-7500</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Gilpin Eric</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Morgan Stanley Smith Barney LLC</name>
          <address>
            <com:street1>1 New York Plaza</com:street1>
            <com:street2>38th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10004</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>120000</noOfUnitsSold>
        <aggregateMarketValue>1653600.00</aggregateMarketValue>
        <noOfUnitsOutstanding>134883597</noOfUnitsOutstanding>
        <approxSaleDate>08/17/2023</approxSaleDate>
        <securitiesExchangeName>NASSAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/17/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>120000</amountOfSecuritiesAcquired>
        <paymentDate>08/17/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>This Form 144 is being filed for the cashless exercise of options and subsequent sales of the underlying shares commencing on 8/17/2023.</remarks>
      <noticeSignature>
        <noticeDate>08/17/2023</noticeDate>
        <signature>/s/ Eric Gilpin</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2978}]
text: 144
  0001809355
  XXXXXXXX
  LIVE
  0001627475
  UPWORK, INC
  001-38678
  475 BRANNAN STREET
  SUITE 430
  SAN FRANCISCO
  CA
  94107
  650-316-7500
  Gilpin Eric
  Officer
  Common
  Morgan Stanley Smith Barney LLC
  1 New York Plaza
  38th Floor
  New York
  NY
  10004
  120000
  1653600.00
  134883597
  08/17/2023
  NASSAQ
  Common
  08/17/2023
  Exercise of options under a registered plan
  Issuer
  N
  120000
  08/17/2023
  Cash
  Y
  This Form 144 is being filed for the cashless exercise of options and subsequent sales of the underlying shares commencing on 8/17/2023.
  08/17/2023
  /s/ Eric Gilpin