content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
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        <issuerName>Apellis Pharmaceuticals, Inc.</issuerName>
        <secFileNumber>001-38276</secFileNumber>
        <issuerAddress>
          <com:street1>100 FIFTH AVENUE</com:street1>
          <com:city>WALTHAM</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-977-5700</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Townsend Adam J.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
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        <aggregateMarketValue>3924267.36</aggregateMarketValue>
        <noOfUnitsOutstanding>125682260</noOfUnitsOutstanding>
        <approxSaleDate>05/12/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <acquiredDate>05/12/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted - 02/08/2019</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
        <paymentDate>05/12/2025</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/12/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted - 11/16/2018</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>172500</amountOfSecuritiesAcquired>
        <paymentDate>05/12/2025</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/28/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1180</amountOfSecuritiesAcquired>
        <paymentDate>01/28/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/21/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>5661</amountOfSecuritiesAcquired>
        <paymentDate>01/21/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/16/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3736</amountOfSecuritiesAcquired>
        <paymentDate>01/16/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/12/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4138</amountOfSecuritiesAcquired>
        <paymentDate>01/12/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/30/2024</acquiredDate>
        <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>501</amountOfSecuritiesAcquired>
        <paymentDate>04/30/2024</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/10/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1196</amountOfSecuritiesAcquired>
        <paymentDate>02/10/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/28/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>969</amountOfSecuritiesAcquired>
        <paymentDate>01/28/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/21/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>5572</amountOfSecuritiesAcquired>
        <paymentDate>01/21/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/12/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4637</amountOfSecuritiesAcquired>
        <paymentDate>01/12/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/28/2023</acquiredDate>
        <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>412</amountOfSecuritiesAcquired>
        <paymentDate>04/28/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/21/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1430</amountOfSecuritiesAcquired>
        <paymentDate>02/21/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/10/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1562</amountOfSecuritiesAcquired>
        <paymentDate>02/10/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/28/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1324</amountOfSecuritiesAcquired>
        <paymentDate>01/28/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/21/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4600</amountOfSecuritiesAcquired>
        <paymentDate>01/21/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/29/2022</acquiredDate>
        <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
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        <amountOfSecuritiesAcquired>769</amountOfSecuritiesAcquired>
        <paymentDate>04/29/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
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        <securitiesClassTitle>Common</securitiesClassTitle>
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        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
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        <paymentDate>02/10/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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        <securitiesClassTitle>Common</securitiesClassTitle>
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        <paymentDate>01/28/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
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        <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
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        <securitiesClassTitle>Common</securitiesClassTitle>
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        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
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        <paymentDate>02/10/2021</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/30/2020</acquiredDate>
        <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
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        <paymentDate>10/30/2020</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/30/2020</acquiredDate>
        <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
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        <paymentDate>04/30/2020</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/12/2025</noticeDate>
        <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Adam J Townsend </signature>
      </noticeSignature>
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metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 14554}]
text: 144
  0001773588
  XXXXXXXX
  LIVE
  0001492422
  Apellis Pharmaceuticals, Inc.
  001-38276
  100 FIFTH AVENUE
  WALTHAM
  MA
  02451
  617-977-5700
  Townsend Adam J.
  Former Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  220961
  3924267.36
  125682260
  05/12/2025
  NASDAQ
  Common
  05/12/2025
  Option Granted - 02/08/2019
  Issuer
  N
  5000
  05/12/2025
  Cash
  Common
  05/12/2025
  Option Granted - 11/16/2018
  Issuer
  N
  172500
  05/12/2025
  Cash
  Common
  01/28/2025
  Restricted Stock Vesting
  Issuer
  N
  1180
  01/28/2025
  Compensation
  Common
  01/21/2025
  Restricted Stock Vesting
  Issuer
  N
  5661
  01/21/2025
  Compensation
  Common
  01/16/2025
  Restricted Stock Vesting
  Issuer
  N
  3736
  01/16/2025
  Compensation
  Common
  01/12/2025
  Restricted Stock Vesting
  Issuer
  N
  4138
  01/12/2025
  Compensation
  Common
  04/30/2024
  ESPP Purchase
  Issuer
  N
  501
  04/30/2024
  Cash
  Common
  02/10/2024
  Restricted Stock Vesting
  Issuer
  N
  1196
  02/10/2024
  Compensation
  Common
  01/28/2024
  Restricted Stock Vesting
  Issuer
  N
  969
  01/28/2024
  Compensation
  Common
  01/21/2024
  Restricted Stock Vesting
  Issuer
  N
  5572
  01/21/2024
  Compensation
  Common
  01/12/2024
  Restricted Stock Vesting
  Issuer
  N
  4637
  01/12/2024
  Compensation
  Common
  04/28/2023
  ESPP Purchase
  Issuer
  N
  412
  04/28/2023
  Cash
  Common
  02/21/2023
  Restricted Stock Vesting
  Issuer
  N
  1430
  02/21/2023
  Compensation
  Common
  02/10/2023
  Restricted Stock Vesting
  Issuer
  N
  1562
  02/10/2023
  Compensation
  Common
  01/28/2023
  Restricted Stock Vesting
  Issuer
  N
  1324
  01/28/2023
  Compensation
  Common
  01/21/2023
  Restricted Stock Vesting
  Issuer
  N
  4600
  01/21/2023
  Compensation
  Common
  04/29/2022
  ESPP Purchase
  Issuer
  N
  769
  04/29/2022
  Cash
  Common
  02/10/2022
  Restricted Stock Vesting
  Issuer
  N
  1449
  02/10/2022
  Compensation
  Common
  01/28/2022
  Restricted Stock Vesting
  Issuer
  N
  1075
  01/28/2022
  Compensation
  Common
  04/30/2021
  ESPP Purchase
  Issuer
  N
  792
  04/30/2021
  Cash
  Common
  02/10/2021
  Restricted Stock Vesting
  Issuer
  N
  1655
  02/10/2021
  Compensation
  Common
  10/30/2020
  ESPP Purchase
  Issuer
  N
  321
  10/30/2020
  Cash
  Common
  04/30/2020
  ESPP Purchase
  Issuer
  N
  482
  04/30/2020
  Cash
  Y
  05/12/2025
  /s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Adam J Townsend