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      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001671311</cik>
            <ccc>XXXXXXXX</ccc>
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        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001724521</issuerCik>
        <issuerName>Arcus Biosciences, Inc.</issuerName>
        <secFileNumber>001-38419</secFileNumber>
        <issuerAddress>
          <com:street1>3928 Point Eden Way</com:street1>
          <com:city>Hayward</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94545</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>510-694-6200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jennifer Jarrett</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>JP Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>57494</noOfUnitsSold>
        <aggregateMarketValue>1177477</aggregateMarketValue>
        <noOfUnitsOutstanding>74503664</noOfUnitsOutstanding>
        <approxSaleDate>09/22/2023</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/15/2023</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>12494</amountOfSecuritiesAcquired>
        <paymentDate>09/15/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1153</amountOfSecuritiesAcquired>
        <paymentDate>12/15/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>12323</amountOfSecuritiesAcquired>
        <paymentDate>09/15/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/15/2021</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>16169</amountOfSecuritiesAcquired>
        <paymentDate>06/15/2021</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>12305</amountOfSecuritiesAcquired>
        <paymentDate>06/15/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/03/2021</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1956</amountOfSecuritiesAcquired>
        <paymentDate>06/03/2021</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/26/2018</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1094</amountOfSecuritiesAcquired>
        <paymentDate>01/26/2018</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Jennifer Jarrett</name>
          <address>
            <com:street1>C/o Arcus Biosciences, Inc.</com:street1>
            <com:street2>3928 Point Eden Way</com:street2>
            <com:city>Hayward</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94545</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>07/28/2023</saleDate>
        <amountOfSecuritiesSold>45000</amountOfSecuritiesSold>
        <grossProceeds>911145</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>09/22/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>02/22/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jennifer Jarrett</signature>
      </noticeSignature>
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metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6825}]
text: 144
  0001671311
  XXXXXXXX
  LIVE
  0001724521
  Arcus Biosciences, Inc.
  001-38419
  3928 Point Eden Way
  Hayward
  CA
  94545
  510-694-6200
  Jennifer Jarrett
  Officer
  Director
  Common
  JP Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  57494
  1177477
  74503664
  09/22/2023
  NYSE
  Common
  09/15/2023
  RSU Vesting
  Issuer
  N
  12494
  09/15/2023
  Compensation
  Common
  12/15/2022
  RSU Vesting
  Issuer
  N
  1153
  12/15/2022
  Compensation
  Common
  09/15/2022
  RSU Vesting
  Issuer
  N
  12323
  09/15/2022
  Compensation
  Common
  06/15/2021
  RSU Vesting
  Issuer
  N
  16169
  06/15/2021
  Compensation
  Common
  06/15/2022
  RSU Vesting
  Issuer
  N
  12305
  06/15/2022
  Compensation
  Common
  06/03/2021
  RSU Vesting
  Issuer
  N
  1956
  06/03/2021
  Compensation
  Common
  01/26/2018
  Stock Option Exercise
  Issuer
  N
  1094
  01/26/2018
  Cash
  N
  Jennifer Jarrett
  C/o Arcus Biosciences, Inc.
  3928 Point Eden Way
  Hayward
  CA
  94545
  Common Stock
  07/28/2023
  45000
  911145
  09/22/2023
  02/22/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jennifer Jarrett