content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001358219</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001727196</issuerCik>
        <issuerName>Scholar Rock Holding Corp</issuerName>
        <secFileNumber>001-38501</secFileNumber>
        <issuerAddress>
          <com:street1>301 Binney Street, 3rd Floor</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>8572593860</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Edward Myles</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>35007</noOfUnitsSold>
        <aggregateMarketValue>430586</aggregateMarketValue>
        <noOfUnitsOutstanding>56232371</noOfUnitsOutstanding>
        <approxSaleDate>11/02/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation RSU</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3859</amountOfSecuritiesAcquired>
        <paymentDate>01/15/2022</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/15/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation RSU</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>13370</amountOfSecuritiesAcquired>
        <paymentDate>01/15/2023</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/15/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation RSU</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>17778</amountOfSecuritiesAcquired>
        <paymentDate>06/15/2023</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/02/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/31/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Edward Myles</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3996}]
text: 144
  0001358219
  XXXXXXXX
  LIVE
  0001727196
  Scholar Rock Holding Corp
  001-38501
  301 Binney Street, 3rd Floor
  Cambridge
  MA
  02142
  8572593860
  Edward Myles
  Officer
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  35007
  430586
  56232371
  11/02/2023
  Nasdaq
  Common
  01/15/2022
  Compensation RSU
  Issuer
  N
  3859
  01/15/2022
  NA
  Common
  01/15/2023
  Compensation RSU
  Issuer
  N
  13370
  01/15/2023
  NA
  Common
  06/15/2023
  Compensation RSU
  Issuer
  N
  17778
  06/15/2023
  NA
  Y
  11/02/2023
  03/31/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Edward Myles