content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001388767</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000039263</issuerCik>
        <issuerName>CULLEN/FROST BANKERS, INC.</issuerName>
        <secFileNumber>001-13221</secFileNumber>
        <issuerAddress>
          <com:street1>111 W HOUSTON ST</com:street1>
          <com:city>SAN ANTONIO</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78205</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>210-220-4011</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Berman Bobby</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>FIDELITY BROKERAGE SERVICES LLC</name>
          <address>
            <com:street1>245 SUMMER STREET</com:street1>
            <com:city>BOSTON</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3506</noOfUnitsSold>
        <aggregateMarketValue>446489.00</aggregateMarketValue>
        <noOfUnitsOutstanding>64131862</noOfUnitsOutstanding>
        <approxSaleDate>11/01/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/29/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2352</amountOfSecuritiesAcquired>
        <paymentDate>10/29/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/04/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1007</amountOfSecuritiesAcquired>
        <paymentDate>05/04/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>11/30/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>25</amountOfSecuritiesAcquired>
        <paymentDate>11/30/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>11/18/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>7</amountOfSecuritiesAcquired>
        <paymentDate>11/18/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/17/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>7</amountOfSecuritiesAcquired>
        <paymentDate>10/17/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/03/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>7</amountOfSecuritiesAcquired>
        <paymentDate>10/03/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>10/31/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>7</amountOfSecuritiesAcquired>
        <paymentDate>10/31/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/31/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>7</amountOfSecuritiesAcquired>
        <paymentDate>08/31/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6</amountOfSecuritiesAcquired>
        <paymentDate>09/15/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/29/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6</amountOfSecuritiesAcquired>
        <paymentDate>07/29/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6</amountOfSecuritiesAcquired>
        <paymentDate>08/15/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3</amountOfSecuritiesAcquired>
        <paymentDate>07/15/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/02/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2</amountOfSecuritiesAcquired>
        <paymentDate>05/02/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/06/2022</acquiredDate>
        <natureOfAcquisitionTransaction>STOCK AWARD</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1</amountOfSecuritiesAcquired>
        <paymentDate>07/06/2022</paymentDate>
        <natureOfPayment>COMPENSATION</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/16/2022</acquiredDate>
        <natureOfAcquisitionTransaction>STOCK AWARD</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1</amountOfSecuritiesAcquired>
        <paymentDate>06/16/2022</paymentDate>
        <natureOfPayment>COMPENSATION</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/16/2022</acquiredDate>
        <natureOfAcquisitionTransaction>STOCK AWARD</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1</amountOfSecuritiesAcquired>
        <paymentDate>05/16/2022</paymentDate>
        <natureOfPayment>COMPENSATION</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/01/2022</acquiredDate>
        <natureOfAcquisitionTransaction>STOCK AWARD</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1</amountOfSecuritiesAcquired>
        <paymentDate>06/01/2022</paymentDate>
        <natureOfPayment>COMPENSATION</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/28/2021</acquiredDate>
        <natureOfAcquisitionTransaction>STOCK AWARD</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>60</amountOfSecuritiesAcquired>
        <paymentDate>12/28/2021</paymentDate>
        <natureOfPayment>COMPENSATION</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/01/2024</noticeDate>
        <signature>/s/ Daniel Gardea as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Berman Bobby.</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 11694}]
text: 144
  0001388767
  XXXXXXXX
  LIVE
  0000039263
  CULLEN/FROST BANKERS, INC.
  001-13221
  111 W HOUSTON ST
  SAN ANTONIO
  TX
  78205
  210-220-4011
  Berman Bobby
  Officer
  Common
  FIDELITY BROKERAGE SERVICES LLC
  245 SUMMER STREET
  BOSTON
  MA
  02110
  3506
  446489.00
  64131862
  11/01/2024
  NYSE
  Common
  10/29/2024
  Stock Award
  ISSUER
  N
  2352
  10/29/2024
  Compensation
  Common
  05/04/2023
  Stock Award
  ISSUER
  N
  1007
  05/04/2023
  Compensation
  Common
  11/30/2022
  Stock Award
  ISSUER
  N
  25
  11/30/2022
  Compensation
  Common
  11/18/2022
  Stock Award
  ISSUER
  N
  7
  11/18/2022
  Compensation
  Common
  10/17/2022
  Stock Award
  ISSUER
  N
  7
  10/17/2022
  Compensation
  Common
  10/03/2022
  Stock Award
  ISSUER
  N
  7
  10/03/2022
  Compensation
  Common
  10/31/2022
  Stock Award
  ISSUER
  N
  7
  10/31/2022
  Compensation
  Common
  08/31/2022
  Stock Award
  ISSUER
  N
  7
  08/31/2022
  Compensation
  Common
  09/15/2022
  Stock Award
  ISSUER
  N
  6
  09/15/2022
  Compensation
  Common
  07/29/2024
  Stock Award
  ISSUER
  N
  6
  07/29/2022
  Compensation
  Common
  08/15/2022
  Stock Award
  ISSUER
  N
  6
  08/15/2022
  Compensation
  Common
  07/15/2022
  Stock Award
  ISSUER
  N
  3
  07/15/2022
  Compensation
  Common
  05/02/2022
  Stock Award
  ISSUER
  N
  2
  05/02/2022
  Compensation
  Common
  07/06/2022
  STOCK AWARD
  ISSUER
  N
  1
  07/06/2022
  COMPENSATION
  Common
  06/16/2022
  STOCK AWARD
  ISSUER
  N
  1
  06/16/2022
  COMPENSATION
  Common
  05/16/2022
  STOCK AWARD
  ISSUER
  N
  1
  05/16/2022
  COMPENSATION
  Common
  06/01/2022
  STOCK AWARD
  ISSUER
  N
  1
  06/01/2022
  COMPENSATION
  Common
  12/28/2021
  STOCK AWARD
  ISSUER
  N
  60
  12/28/2021
  COMPENSATION
  Y
  11/01/2024
  /s/ Daniel Gardea as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Berman Bobby.