content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
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        <filer>
          <filerCredentials>
            <cik>0001432824</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001423689</issuerCik>
        <issuerName>AGNC Investment Corp.</issuerName>
        <secFileNumber>001-34057</secFileNumber>
        <issuerAddress>
          <com:street1>7373 WISCONSIN AVENUE, 22ND FLOOR</com:street1>
          <com:city>BETHESDA</com:city>
          <com:stateOrCountry>MD</com:stateOrCountry>
          <com:zipCode>20814</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>301 968 9300</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Davis Morris A.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>57285</noOfUnitsSold>
        <aggregateMarketValue>594331.88</aggregateMarketValue>
        <noOfUnitsOutstanding>900421216</noOfUnitsOutstanding>
        <approxSaleDate>03/19/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/16/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>57285</amountOfSecuritiesAcquired>
        <paymentDate>03/16/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>03/19/2025</noticeDate>
        <signature>/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Morris Davis</signature>
      </noticeSignature>
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text: 144
  0001432824
  XXXXXXXX
  LIVE
  0001423689
  AGNC Investment Corp.
  001-34057
  7373 WISCONSIN AVENUE, 22ND FLOOR
  BETHESDA
  MD
  20814
  301 968 9300
  Davis Morris A.
  Former Director
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  57285
  594331.88
  900421216
  03/19/2025
  NASDAQ
  Common
  03/16/2025
  Restricted Stock Vesting
  Issuer
  N
  57285
  03/16/2025
  Compensation
  Y
  03/19/2025
  /s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Morris Davis