content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001766042</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001844565</issuerCik>
        <issuerName>Soleno Therapeutics</issuerName>
        <secFileNumber>021-391904</secFileNumber>
        <issuerAddress>
          <com:street1>203 Redwood Shores Parkway, Suite 500</com:street1>
          <com:city>Redwood City</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94065</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>650-213-8444</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Hirano Patricia C</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Patricia Hirano (Trustee) is an employee of Issuer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>245 Summer Street</com:street1>
            <com:city>BOSTON</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02110</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1359</noOfUnitsSold>
        <aggregateMarketValue>50609.00</aggregateMarketValue>
        <noOfUnitsOutstanding>30499352</noOfUnitsOutstanding>
        <approxSaleDate>12/14/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/26/2017</acquiredDate>
        <natureOfAcquisitionTransaction>Merger/Acquisition</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1359</amountOfSecuritiesAcquired>
        <paymentDate>04/26/2017</paymentDate>
        <natureOfPayment>Cash/Check</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Renshaw-Hirano Trust - TODD RENSHAW, P C HIRANO TTEE
  RENSHAW-HIRANO TRUST
  U/A 8/21/12</remarks>
      <noticeSignature>
        <noticeDate>12/14/2023</noticeDate>
        <signature>/s/ Jordyn Davis as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Hirano Patricia C</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3058}]
text: 144
  0001766042
  XXXXXXXX
  LIVE
  0001844565
  Soleno Therapeutics
  021-391904
  203 Redwood Shores Parkway, Suite 500
  Redwood City
  CA
  94065
  650-213-8444
  Hirano Patricia C
  Officer
  Patricia Hirano (Trustee) is an employee of Issuer
  Common
  Fidelity Brokerage Services LLC
  245 Summer Street
  BOSTON
  MA
  02110
  1359
  50609.00
  30499352
  12/14/2023
  NASDAQ
  Common
  04/26/2017
  Merger/Acquisition
  Issuer
  N
  1359
  04/26/2017
  Cash/Check
  Y
  Renshaw-Hirano Trust - TODD RENSHAW, P C HIRANO TTEE
  RENSHAW-HIRANO TRUST
  U/A 8/21/12
  12/14/2023
  /s/ Jordyn Davis as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Hirano Patricia C