content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001860010</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001711279</issuerCik>
        <issuerName>Krystal Biotech, Inc.</issuerName>
        <secFileNumber>001-38210</secFileNumber>
        <issuerAddress>
          <com:street1>2100 WHARTON STREET</com:street1>
          <com:street2>SUITE 701</com:street2>
          <com:city>PITTSBURGH</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>15203</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(412) 586-5830</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ORTH ANDREW C.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former EVP &amp; CCO</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1503</noOfUnitsSold>
        <aggregateMarketValue>183392.02</aggregateMarketValue>
        <noOfUnitsOutstanding>27994177</noOfUnitsOutstanding>
        <approxSaleDate>08/11/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/11/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted - 05/31/2021</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1503</amountOfSecuritiesAcquired>
        <paymentDate>08/11/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Andrew C. Orth</name>
          <address>
            <com:street1>2100 Wharton Street</com:street1>
            <com:street2>Suite 701</com:street2>
            <com:city>Pittsburgh</com:city>
            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>15203</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>06/09/2023</saleDate>
        <amountOfSecuritiesSold>12500</amountOfSecuritiesSold>
        <grossProceeds>1607116.13</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Andrew C. Orth</name>
          <address>
            <com:street1>2100 Wharton Street</com:street1>
            <com:street2>Suite 701</com:street2>
            <com:city>Pittsburgh</com:city>
            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>15203</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>08/10/2023</saleDate>
        <amountOfSecuritiesSold>5606</amountOfSecuritiesSold>
        <grossProceeds>685184.94</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>08/11/2023</noticeDate>
        <signature>/s/ Jared Cook, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Andrew C. Orth</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001860010
  XXXXXXXX
  LIVE
  0001711279
  Krystal Biotech, Inc.
  001-38210
  2100 WHARTON STREET
  SUITE 701
  PITTSBURGH
  PA
  15203
  (412) 586-5830
  ORTH ANDREW C.
  Former EVP & CCO
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  1503
  183392.02
  27994177
  08/11/2023
  NASDAQ
  Common
  08/11/2023
  Option Granted - 05/31/2021
  Issuer
  N
  1503
  08/11/2023
  Cash
  N
  Andrew C. Orth
  2100 Wharton Street
  Suite 701
  Pittsburgh
  PA
  15203
  Common
  06/09/2023
  12500
  1607116.13
  Andrew C. Orth
  2100 Wharton Street
  Suite 701
  Pittsburgh
  PA
  15203
  Common
  08/10/2023
  5606
  685184.94
  08/11/2023
  /s/ Jared Cook, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Andrew C. Orth