content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001586657</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001445499</issuerCik>
        <issuerName>IMPEL PHARMACEUTICALS INC</issuerName>
        <secFileNumber>001-40353</secFileNumber>
        <issuerAddress>
          <com:street1>201 ELLIOTT AVE. W</com:street1>
          <com:street2>SUITE 260</com:street2>
          <com:city>SEATTLE</com:city>
          <com:stateOrCountry>WA</com:stateOrCountry>
          <com:zipCode>98119</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>206-568-1466</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Leaman John Harold</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>TD AMERITRADE</name>
          <address>
            <com:street1>200 SOUTH 108TH AVE</com:street1>
            <com:city>OMAHA</com:city>
            <com:stateOrCountry>NE</com:stateOrCountry>
            <com:zipCode>68154</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>6944</noOfUnitsSold>
        <aggregateMarketValue>15971.20</aggregateMarketValue>
        <noOfUnitsOutstanding>23746257</noOfUnitsOutstanding>
        <approxSaleDate>05/11/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <acquiredDate>12/31/2022</acquiredDate>
        <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>IMPEL PHARMACEUTICALS</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>6944</amountOfSecuritiesAcquired>
        <paymentDate>12/31/2022</paymentDate>
        <natureOfPayment>RESTRICTED STOCK</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>JOHN LEAMAN</name>
          <address>
            <com:street1>2850 GRAYSTONE RD</com:street1>
            <com:city>EAST PETERSBURG</com:city>
            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>17520</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <saleDate>05/10/2023</saleDate>
        <amountOfSecuritiesSold>2226</amountOfSecuritiesSold>
        <grossProceeds>5428.34</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>JOHN LEAMAN</name>
          <address>
            <com:street1>2850 GRAYSTONE RD</com:street1>
            <com:city>EAST PETERSBURG</com:city>
            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>17520</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <saleDate>05/11/2023</saleDate>
        <amountOfSecuritiesSold>2774</amountOfSecuritiesSold>
        <grossProceeds>6770.85</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>05/11/2023</noticeDate>
        <signature>JOHN LEAMAN</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3930}]
text: 144
  0001586657
  XXXXXXXX
  LIVE
  0001445499
  IMPEL PHARMACEUTICALS INC
  001-40353
  201 ELLIOTT AVE. W
  SUITE 260
  SEATTLE
  WA
  98119
  206-568-1466
  Leaman John Harold
  Former Officer
  COMMON
  TD AMERITRADE
  200 SOUTH 108TH AVE
  OMAHA
  NE
  68154
  6944
  15971.20
  23746257
  05/11/2023
  NASDAQ
  COMMON
  12/31/2022
  RESTRICTED STOCK
  IMPEL PHARMACEUTICALS
  N
  6944
  12/31/2022
  RESTRICTED STOCK
  N
  JOHN LEAMAN
  2850 GRAYSTONE RD
  EAST PETERSBURG
  PA
  17520
  COMMON
  05/10/2023
  2226
  5428.34
  JOHN LEAMAN
  2850 GRAYSTONE RD
  EAST PETERSBURG
  PA
  17520
  COMMON
  05/11/2023
  2774
  6770.85
  05/11/2023
  JOHN LEAMAN