content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001243621</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001069258</issuerCik>
        <issuerName>Kratos Defense &amp; Security Solutions, Inc.</issuerName>
        <secFileNumber>001-34460</secFileNumber>
        <issuerAddress>
          <com:street1>10680 Treena Street, Suite 600</com:street1>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92131</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>858-812-7300</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Scott Anderson</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>31000</noOfUnitsSold>
        <aggregateMarketValue>613800</aggregateMarketValue>
        <noOfUnitsOutstanding>150098184</noOfUnitsOutstanding>
        <approxSaleDate>06/17/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/02/1998</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>30000</amountOfSecuritiesAcquired>
        <paymentDate>03/02/1998</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/01/2008</acquiredDate>
        <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Open Market Purchase</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1000</amountOfSecuritiesAcquired>
        <paymentDate>12/01/2008</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The shares filed today will be sold by Scott I Anderson and Monica M Anderson Comm Prop</remarks>
      <noticeSignature>
        <noticeDate>06/17/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/15/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Scott I Anderson.</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3646}]
text: 144
  0001243621
  XXXXXXXX
  LIVE
  0001069258
  Kratos Defense & Security Solutions, Inc.
  001-34460
  10680 Treena Street, Suite 600
  San Diego
  CA
  92131
  858-812-7300
  Scott Anderson
  Director
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  31000
  613800
  150098184
  06/17/2024
  Nasdaq
  Common
  03/02/1998
  Stock Option Exercise
  Issuer
  N
  30000
  03/02/1998
  Cash
  Common
  12/01/2008
  Open Market Purchase
  Open Market Purchase
  N
  1000
  12/01/2008
  Cash
  Y
  The shares filed today will be sold by Scott I Anderson and Monica M Anderson Comm Prop
  06/17/2024
  03/15/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Scott I Anderson.