content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001407451</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001001316</issuerCik>
        <issuerName>TG THERAPEUTICS, INC.</issuerName>
        <secFileNumber>001-32639</secFileNumber>
        <issuerAddress>
          <com:street1>2 GANSEVOORT STREET, 9TH FLOOR</com:street1>
          <com:city>NEW YORK</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10014</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(212) 554-4484</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Charney Laurence N</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>TG THERAPEUTICS, INC.</name>
          <address>
            <com:street1>2 GANSEVOORT STREET</com:street1>
            <com:street2>9TH FLOOR</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10014</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>25000</noOfUnitsSold>
        <aggregateMarketValue>754872.53</aggregateMarketValue>
        <noOfUnitsOutstanding>155665334</noOfUnitsOutstanding>
        <approxSaleDate>11/11/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/01/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>25000</amountOfSecuritiesAcquired>
        <paymentDate>01/01/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/12/2024</noticeDate>
        <signature>/s/ Andrew Glade, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Laurence Charney</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2893}]
text: 144
  0001407451
  XXXXXXXX
  LIVE
  0001001316
  TG THERAPEUTICS, INC.
  001-32639
  2 GANSEVOORT STREET, 9TH FLOOR
  NEW YORK
  NY
  10014
  (212) 554-4484
  Charney Laurence N
  Director
  Common
  TG THERAPEUTICS, INC.
  2 GANSEVOORT STREET
  9TH FLOOR
  New York
  NY
  10014
  25000
  754872.53
  155665334
  11/11/2024
  NASDAQ
  Common
  01/01/2023
  Restricted Stock Vesting
  Issuer
  N
  25000
  01/01/2023
  Compensation
  Y
  11/12/2024
  /s/ Andrew Glade, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Laurence Charney