content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001835780</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001704292</issuerCik>
        <issuerName>Zai Lab Ltd</issuerName>
        <secFileNumber>001-38205</secFileNumber>
        <issuerAddress>
          <com:street1>4560 JINKE ROAD</com:street1>
          <com:street2>BLDG. 1, 4F, PUDONG</com:street2>
          <com:city>SHANGHAI</com:city>
          <com:stateOrCountry>F4</com:stateOrCountry>
          <com:zipCode>201210</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>862161632588</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Edmondson Frazor Titus III</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1874</noOfUnitsSold>
        <aggregateMarketValue>62045.33</aggregateMarketValue>
        <noOfUnitsOutstanding>847651100</noOfUnitsOutstanding>
        <approxSaleDate>04/04/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <acquiredDate>04/03/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1874</amountOfSecuritiesAcquired>
        <paymentDate>04/03/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Frazor T. Edmondson</name>
          <address>
            <com:street1>4560 Jinke Road</com:street1>
            <com:street2>Bldg. 1, Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>02/28/2025</saleDate>
        <amountOfSecuritiesSold>14544</amountOfSecuritiesSold>
        <grossProceeds>479661.12</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Frazor T. Edmondson</name>
          <address>
            <com:street1>4560 Jinke Road, Bldg. 1</com:street1>
            <com:street2>Fourth Floor Pudong</com:street2>
            <com:city>Shanghai</com:city>
            <com:stateOrCountry>F4</com:stateOrCountry>
            <com:zipCode>201210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
        <saleDate>04/02/2025</saleDate>
        <amountOfSecuritiesSold>4369</amountOfSecuritiesSold>
        <grossProceeds>156821.76</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
      <noticeSignature>
        <noticeDate>04/04/2025</noticeDate>
        <signature>/s/ Emily Navaro, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for  Frazor T. Edmondson.</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001835780
  XXXXXXXX
  LIVE
  0001704292
  Zai Lab Ltd
  001-38205
  4560 JINKE ROAD
  BLDG. 1, 4F, PUDONG
  SHANGHAI
  F4
  201210
  862161632588
  Edmondson Frazor Titus III
  Officer
  American Depositary Shares
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  1874
  62045.33
  847651100
  04/04/2025
  NASDAQ
  American Depositary Shares
  04/03/2025
  Restricted Stock Vesting
  Issuer
  N
  1874
  04/03/2025
  Compensation
  N
  Frazor T. Edmondson
  4560 Jinke Road
  Bldg. 1, Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  02/28/2025
  14544
  479661.12
  Frazor T. Edmondson
  4560 Jinke Road, Bldg. 1
  Fourth Floor Pudong
  Shanghai
  F4
  201210
  American Depositary Shares
  04/02/2025
  4369
  156821.76
  Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.
  04/04/2025
  /s/ Emily Navaro, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for  Frazor T. Edmondson.