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          <com:street2>SUITE F200</com:street2>
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            <com:street2>Floor 37</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10281</com:zipCode>
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            <com:zipCode>19087</com:zipCode>
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            <com:zipCode>19087</com:zipCode>
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            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>19087</com:zipCode>
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        <saleDate>06/14/2024</saleDate>
        <amountOfSecuritiesSold>16229</amountOfSecuritiesSold>
        <grossProceeds>203163.11</grossProceeds>
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            <com:street2>SUITE F200</com:street2>
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            <com:stateOrCountry>PA</com:stateOrCountry>
            <com:zipCode>19087</com:zipCode>
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        <planAdoptionDates>
          <planAdoptionDate>01/30/2024</planAdoptionDate>
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        <signature>Jon Congleton</signature>
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text: 144
  0001644975
  XXXXXXXX
  LIVE
  0001933414
  Mineralys Therapeutics, Inc.
  001-41614
  150 N. RADNOR CHESTER ROAD
  SUITE F200
  RADNOR
  PA
  19087
  (888) 378-6240
  Congleton Jon
  Officer
  Common Stock
  Merrill Lynch
  225 Liberty St
  Floor 37
  New York
  NY
  10281
  14940
  175237.41
  49648540
  06/20/2024
  NASDAQ
  Common Stock
  06/10/2024
  Vesting of restricted stock unit award
  Mineralys Therapeutics, Inc.
  N
  14940
  06/10/2024
  Granted as part of issuer equity compensation plan
  N
  Jon Congleton
  150 N. RADNOR CHESTER ROAD
  SUITE F200
  RADNOR
  PA
  19087
  Common Stock
  06/12/2024
  16607
  212013.19
  Jon Congleton
  150 N. RADNOR CHESTER ROAD
  SUITE F200
  RADNOR
  PA
  19087
  Common Stock
  06/13/2024
  39961
  509027.74
  Jon Congleton
  150 N. RADNOR CHESTER ROAD
  SUITE F200
  RADNOR
  PA
  19087
  Common Stock
  06/14/2024
  16229
  203163.11
  Jon Congleton
  150 N. RADNOR CHESTER ROAD
  SUITE F200
  RADNOR
  PA
  19087
  Common Stock
  06/17/2024
  17766
  217711.02
  Jon Congleton
  150 N. RADNOR CHESTER ROAD
  SUITE F200
  RADNOR
  PA
  19087
  Common Stock
  06/18/2024
  16607
  199072.34
  06/20/2024
  01/30/2024
  Jon Congleton