content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001279473</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001369568</issuerCik>
        <issuerName>CATALYST PHARMACEUTICALS, INC.</issuerName>
        <secFileNumber>001-33057</secFileNumber>
        <issuerAddress>
          <com:street1>355 ALHAMBRA CIRCLE</com:street1>
          <com:street2>SUITE 801</com:street2>
          <com:city>CORAL GABLES</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33134</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(305) 529-2522</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>INGENITO GARY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>50000</noOfUnitsSold>
        <aggregateMarketValue>713500.00</aggregateMarketValue>
        <noOfUnitsOutstanding>106611456</noOfUnitsOutstanding>
        <approxSaleDate>12/06/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/06/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Option Granted - 01/03/2017</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
        <paymentDate>12/06/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/06/2023</noticeDate>
        <signature>/s/ Bradley Camilo, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Gary Ingenito</signature>
      </noticeSignature>
    </formData>
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metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2890}]
text: 144
  0001279473
  XXXXXXXX
  LIVE
  0001369568
  CATALYST PHARMACEUTICALS, INC.
  001-33057
  355 ALHAMBRA CIRCLE
  SUITE 801
  CORAL GABLES
  FL
  33134
  (305) 529-2522
  INGENITO GARY
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  50000
  713500.00
  106611456
  12/06/2023
  NASDAQ
  Common
  12/06/2023
  Option Granted - 01/03/2017
  Issuer
  N
  50000
  12/06/2023
  Cash
  Y
  12/06/2023
  /s/ Bradley Camilo, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Gary Ingenito