content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001744425</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001737953</issuerCik>
        <issuerName>Replimune Group Inc.</issuerName>
        <secFileNumber>001-38596</secFileNumber>
        <issuerAddress>
          <com:street1>500 Unicorn Park Drive</com:street1>
          <com:street2>Suite 303</com:street2>
          <com:city>Woburn</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>01801</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>7812229600</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Pamela Esposito</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>80000</noOfUnitsSold>
        <aggregateMarketValue>1694400</aggregateMarketValue>
        <noOfUnitsOutstanding>57775993</noOfUnitsOutstanding>
        <approxSaleDate>07/10/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>07/10/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>80000</amountOfSecuritiesAcquired>
        <paymentDate>07/10/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>07/10/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/15/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Pamela Esposito</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3000}]
text: 144
  0001744425
  XXXXXXXX
  LIVE
  0001737953
  Replimune Group Inc.
  001-38596
  500 Unicorn Park Drive
  Suite 303
  Woburn
  MA
  01801
  7812229600
  Pamela Esposito
  Officer
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  80000
  1694400
  57775993
  07/10/2023
  Nasdaq
  Common
  07/10/2023
  Stock Option Exercise
  Issuer
  N
  80000
  07/10/2023
  Cash
  Y
  07/10/2023
  03/15/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Pamela Esposito