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        <issuerAddress>
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          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
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        <issuerContactPhone>857-449-2244</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Andrew Miller</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>JPMorgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Ave</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
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        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>45000</noOfUnitsSold>
        <aggregateMarketValue>8894250</aggregateMarketValue>
        <noOfUnitsOutstanding>34515033</noOfUnitsOutstanding>
        <approxSaleDate>04/18/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/21/2019</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
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        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>38500</amountOfSecuritiesAcquired>
        <paymentDate>03/21/2019</paymentDate>
        <natureOfPayment>cash</natureOfPayment>
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        <isGiftTransaction>N</isGiftTransaction>
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        <paymentDate>11/02/2021</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
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      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>04/18/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>09/16/2022</planAdoptionDate>
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        <signature>/s/ JPMS LLC as agent and attorney-in-fact for Andrew Milleri</signature>
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text: 144
  0001777760
  XXXXXXXX
  LIVE
  0001771917
  KarunaTherapeutics Inc.
  001-38958
  99 High St
  Boston
  MA
  02110
  857-449-2244
  Andrew Miller
  Affiliate
  Common
  JPMorgan Securities LLC
  390 Madison Ave
  6th Floor
  New York
  NY
  10017
  45000
  8894250
  34515033
  04/18/2023
  Nasdaq
  Common
  03/21/2019
  Stock Option Exercise
  Issuer
  N
  38500
  03/21/2019
  cash
  Common
  11/02/2021
  Compensation
  Issuer
  N
  6500
  11/02/2021
  Compensation
  Y
  04/18/2023
  09/16/2022
  /s/ JPMS LLC as agent and attorney-in-fact for Andrew Milleri