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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001557290</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
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      <issuerInfo>
        <issuerCik>0000875320</issuerCik>
        <issuerName>VERTEX PHARMACEUTICALS INC / MA</issuerName>
        <secFileNumber>000-19319</secFileNumber>
        <issuerAddress>
          <com:street1>50 NORTHERN AVENUE</com:street1>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>6173416393</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Arbuckle Stuart A</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Fidelity Brokerage Services LLC</name>
          <address>
            <com:street1>900 Salem Street</com:street1>
            <com:city>Smithfield</com:city>
            <com:stateOrCountry>RI</com:stateOrCountry>
            <com:zipCode>02917</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3603</noOfUnitsSold>
        <aggregateMarketValue>1519637.31</aggregateMarketValue>
        <noOfUnitsOutstanding>258307816</noOfUnitsOutstanding>
        <approxSaleDate>02/21/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/20/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Performance Shares</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3603</amountOfSecuritiesAcquired>
        <paymentDate>02/20/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Stuart A. Arbuckle</name>
          <address>
            <com:street1>50 Northern Avenue</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/13/2023</saleDate>
        <amountOfSecuritiesSold>8603</amountOfSecuritiesSold>
        <grossProceeds>3432597.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Stuart A. Arbuckle</name>
          <address>
            <com:street1>50 Northern Avenue</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/12/2024</saleDate>
        <amountOfSecuritiesSold>4295</amountOfSecuritiesSold>
        <grossProceeds>1804930.80</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Stuart A. Arbuckle</name>
          <address>
            <com:street1>50 Northern Avenue</com:street1>
            <com:city>Boston</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02210</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>02/20/2024</saleDate>
        <amountOfSecuritiesSold>4804</amountOfSecuritiesSold>
        <grossProceeds>2021475.16</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>02/21/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>02/28/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Andrew Glade, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Stuart A. Arbuckle</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001557290
  XXXXXXXX
  LIVE
  0000875320
  VERTEX PHARMACEUTICALS INC / MA
  000-19319
  50 NORTHERN AVENUE
  BOSTON
  MA
  02210
  6173416393
  Arbuckle Stuart A
  Officer
  Common
  Fidelity Brokerage Services LLC
  900 Salem Street
  Smithfield
  RI
  02917
  3603
  1519637.31
  258307816
  02/21/2024
  NASDAQ
  Common
  02/20/2024
  Performance Shares
  Issuer
  N
  3603
  02/20/2024
  Compensation
  N
  Stuart A. Arbuckle
  50 Northern Avenue
  Boston
  MA
  02210
  Common
  12/13/2023
  8603
  3432597.00
  Stuart A. Arbuckle
  50 Northern Avenue
  Boston
  MA
  02210
  Common
  02/12/2024
  4295
  1804930.80
  Stuart A. Arbuckle
  50 Northern Avenue
  Boston
  MA
  02210
  Common
  02/20/2024
  4804
  2021475.16
  02/21/2024
  02/28/2023
  /s/ Andrew Glade, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Stuart A. Arbuckle