content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <!-- Field: Pseudo-Tag; ID: Name; Data: Casdin Partners Master Fund, L.P. -->
            <cik>0001534265</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000834365</issuerCik>
        <issuerName>BioLife Solutions, Inc.</issuerName>
        <secFileNumber>001-36362</secFileNumber>
        <issuerAddress>
          <com:street1>3303 Monte Villa Parkway, Suite 310</com:street1>
          <com:city>Bothell</com:city>
          <com:stateOrCountry>WA</com:stateOrCountry>
          <com:zipCode>98021</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>425-402-1400</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Casdin Partners Master Fund, L.P.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>10% Shareholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock, par value $0.001 per share</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>BMO Capital Markets</name>
          <address>
            <com:street1>151 W 42nd St</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10036</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1000000</noOfUnitsSold>
        <aggregateMarketValue>23910000.00</aggregateMarketValue>
        <noOfUnitsOutstanding>47561171</noOfUnitsOutstanding>
        <approxSaleDate>06/10/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock, par value $0.001 per share</securitiesClassTitle>
        <acquiredDate>12/16/2020</acquiredDate>
        <natureOfAcquisitionTransaction>Purchase</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>The shares were purchased directly from a shareholder of the issuer.</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1000000</amountOfSecuritiesAcquired>
        <paymentDate>12/16/2020</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>06/10/2025</noticeDate>
        <signature>/s/ Eli Casdin</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2947}]
text: 144
  0001534265
  XXXXXXXX
  LIVE
  0000834365
  BioLife Solutions, Inc.
  001-36362
  3303 Monte Villa Parkway, Suite 310
  Bothell
  WA
  98021
  425-402-1400
  Casdin Partners Master Fund, L.P.
  10% Shareholder
  Common Stock, par value $0.001 per share
  BMO Capital Markets
  151 W 42nd St
  New York
  NY
  10036
  1000000
  23910000.00
  47561171
  06/10/2025
  NASDAQ
  Common Stock, par value $0.001 per share
  12/16/2020
  Purchase
  The shares were purchased directly from a shareholder of the issuer.
  N
  1000000
  12/16/2020
  Cash
  Y
  06/10/2025
  /s/ Eli Casdin