content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001250333</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001327567</issuerCik>
        <issuerName>Palo Alto Networks, Inc.</issuerName>
        <secFileNumber>001-35594</secFileNumber>
        <issuerAddress>
          <com:street1>3000 Tannery Way</com:street1>
          <com:city>Santa Clara</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>95054</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>408-753-4000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Nir Zuk</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>300000</noOfUnitsSold>
        <aggregateMarketValue>61392000</aggregateMarketValue>
        <noOfUnitsOutstanding>666800000</noOfUnitsOutstanding>
        <approxSaleDate>07/01/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>01/20/2020</acquiredDate>
        <natureOfAcquisitionTransaction>Granted by Zir Zuk who acquired the shares as compensation and granted to trust on day of awards.</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>300000</amountOfSecuritiesAcquired>
        <paymentDate>01/20/2020</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Hawk Family Trust</name>
          <address>
            <com:street1>Care of Palo Alto Networks Inc</com:street1>
            <com:street2>3000 Tannery Way</com:street2>
            <com:city>Santa Clara</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>95054</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/11/2025</saleDate>
        <amountOfSecuritiesSold>100000</amountOfSecuritiesSold>
        <grossProceeds>16541279</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Hawk Family Trust</name>
          <address>
            <com:street1>Care of Palo Alto Networks Inc</com:street1>
            <com:street2>3000 Tannery Way</com:street2>
            <com:city>Santa Clara</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>95054</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>05/01/2025</saleDate>
        <amountOfSecuritiesSold>100000</amountOfSecuritiesSold>
        <grossProceeds>18780384</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Hawk Family Trust</name>
          <address>
            <com:street1>Care of Palo Alto Networks Inc</com:street1>
            <com:street2>3000 Tannery Way</com:street2>
            <com:city>Santa Clara</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>95054</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>06/02/2025</saleDate>
        <amountOfSecuritiesSold>100000</amountOfSecuritiesSold>
        <grossProceeds>19336501</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>The Cliff Family Trust FBO Ameet Zuk-Tepman</name>
          <address>
            <com:street1>Care of Palo Alto Networks Inc</com:street1>
            <com:street2>3000 Tannery Way</com:street2>
            <com:city>Santa Clara</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>95054</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/11/2025</saleDate>
        <amountOfSecuritiesSold>109962</amountOfSecuritiesSold>
        <grossProceeds>18189122</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>The Cliff Family Trust FBO Danielle Zuk-Tepman</name>
          <address>
            <com:street1>Care of Palo Alto Networks Inc</com:street1>
            <com:street2>3000 Tannery Way</com:street2>
            <com:city>Santa Clara</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>95054</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/11/2025</saleDate>
        <amountOfSecuritiesSold>109962</amountOfSecuritiesSold>
        <grossProceeds>18189122</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>The Cliff Family Trust FBO Guy Zuk</name>
          <address>
            <com:street1>Care of Palo Alto Networks Inc</com:street1>
            <com:street2>3000 Tannery Way</com:street2>
            <com:city>Santa Clara</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>95054</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/11/2025</saleDate>
        <amountOfSecuritiesSold>109968</amountOfSecuritiesSold>
        <grossProceeds>18190114</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>The Cliff Family Trust FBO Maayan Haziza</name>
          <address>
            <com:street1>Care of Palo Alto Networks Inc</com:street1>
            <com:street2>3000 Tannery Way</com:street2>
            <com:city>Santa Clara</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>95054</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/11/2025</saleDate>
        <amountOfSecuritiesSold>109968</amountOfSecuritiesSold>
        <grossProceeds>18190114</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>The Cliff Family Trust FBO Maya Zuk</name>
          <address>
            <com:street1>Care of Palo Alto Networks Inc</com:street1>
            <com:street2>3000 Tannery Way</com:street2>
            <com:city>Santa Clara</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>95054</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/11/2025</saleDate>
        <amountOfSecuritiesSold>109968</amountOfSecuritiesSold>
        <grossProceeds>18190114</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>The shares covered by this filing are shares expected to be sold within 3 months of this filing by Hawk Family Trust Dtd 10/29/12 (Nir Zuk as Trustee).  The shares were acquired 01/20/20 through 04/20/24.</remarks>
      <noticeSignature>
        <noticeDate>07/01/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>01/09/2025</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Nir Zuk</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 8614}]
text: 144
  0001250333
  XXXXXXXX
  LIVE
  0001327567
  Palo Alto Networks, Inc.
  001-35594
  3000 Tannery Way
  Santa Clara
  CA
  95054
  408-753-4000
  Nir Zuk
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  300000
  61392000
  666800000
  07/01/2025
  NASDAQ
  Common
  01/20/2020
  Granted by Zir Zuk who acquired the shares as compensation and granted to trust on day of awards.
  Issuer
  N
  300000
  01/20/2020
  N/A
  N
  Hawk Family Trust
  Care of Palo Alto Networks Inc
  3000 Tannery Way
  Santa Clara
  CA
  95054
  Common
  04/11/2025
  100000
  16541279
  Hawk Family Trust
  Care of Palo Alto Networks Inc
  3000 Tannery Way
  Santa Clara
  CA
  95054
  Common
  05/01/2025
  100000
  18780384
  Hawk Family Trust
  Care of Palo Alto Networks Inc
  3000 Tannery Way
  Santa Clara
  CA
  95054
  Common
  06/02/2025
  100000
  19336501
  The Cliff Family Trust FBO Ameet Zuk-Tepman
  Care of Palo Alto Networks Inc
  3000 Tannery Way
  Santa Clara
  CA
  95054
  Common
  04/11/2025
  109962
  18189122
  The Cliff Family Trust FBO Danielle Zuk-Tepman
  Care of Palo Alto Networks Inc
  3000 Tannery Way
  Santa Clara
  CA
  95054
  Common
  04/11/2025
  109962
  18189122
  The Cliff Family Trust FBO Guy Zuk
  Care of Palo Alto Networks Inc
  3000 Tannery Way
  Santa Clara
  CA
  95054
  Common
  04/11/2025
  109968
  18190114
  The Cliff Family Trust FBO Maayan Haziza
  Care of Palo Alto Networks Inc
  3000 Tannery Way
  Santa Clara
  CA
  95054
  Common
  04/11/2025
  109968
  18190114
  The Cliff Family Trust FBO Maya Zuk
  Care of Palo Alto Networks Inc
  3000 Tannery Way
  Santa Clara
  CA
  95054
  Common
  04/11/2025
  109968
  18190114
  The shares covered by this filing are shares expected to be sold within 3 months of this filing by Hawk Family Trust Dtd 10/29/12 (Nir Zuk as Trustee).  The shares were acquired 01/20/20 through 04/20/24.
  07/01/2025
  01/09/2025
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Nir Zuk