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        <filer>
          <filerCredentials>
            <cik>0001586852</cik>
            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001854270</issuerCik>
        <issuerName>Senti Biosciences Inc</issuerName>
        <secFileNumber>001-40440</secFileNumber>
        <issuerAddress>
          <com:street1>2 Corporate Drive, First Floor</com:street1>
          <com:city>South San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>650-382-3281</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Omid C Farokhzad</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Former Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
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      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>83277</noOfUnitsSold>
        <aggregateMarketValue>179878.32</aggregateMarketValue>
        <noOfUnitsOutstanding>4588645</noOfUnitsOutstanding>
        <approxSaleDate>12/02/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/08/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Founder shares</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>83277</amountOfSecuritiesAcquired>
        <paymentDate>06/08/2022</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/02/2024</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for  Omid C Farokhzad</signature>
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text: 144
  0001586852
  XXXXXXXX
  LIVE
  0001854270
  Senti Biosciences Inc
  001-40440
  2 Corporate Drive, First Floor
  South San Francisco
  CA
  94080
  650-382-3281
  Omid C Farokhzad
  Former Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  83277
  179878.32
  4588645
  12/02/2024
  Nasdaq
  Common
  06/08/2022
  Founder shares
  Issuer
  N
  83277
  06/08/2022
  N/A
  Y
  12/02/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for  Omid C Farokhzad