content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001361519</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001156375</issuerCik>
        <issuerName>CME Group, Inc.</issuerName>
        <secFileNumber>001-31553</secFileNumber>
        <issuerAddress>
          <com:street1>20 South Wacker Drive</com:street1>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60606</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>312-930-1000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Dennis Suskind</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue, 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1000</noOfUnitsSold>
        <aggregateMarketValue>268240</aggregateMarketValue>
        <noOfUnitsOutstanding>360354174</noOfUnitsOutstanding>
        <approxSaleDate>04/29/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <acquiredDate>10/09/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>748</amountOfSecuritiesAcquired>
        <paymentDate>10/09/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <acquiredDate>06/26/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>811</amountOfSecuritiesAcquired>
        <paymentDate>06/26/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <acquiredDate>06/27/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>693</amountOfSecuritiesAcquired>
        <paymentDate>06/27/2022</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>04/29/2025</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Dennis Suskind</signature>
      </noticeSignature>
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text: 144
  0001361519
  XXXXXXXX
  LIVE
  0001156375
  CME Group, Inc.
  001-31553
  20 South Wacker Drive
  Chicago
  IL
  60606
  312-930-1000
  Dennis Suskind
  Director
  Class A Common Stock
  J.P. Morgan Securities LLC
  390 Madison Avenue, 6th Floor
  New York
  NY
  10017
  1000
  268240
  360354174
  04/29/2025
  NASDAQ
  Class A Common Stock
  10/09/2024
  Compensation
  Issuer
  N
  748
  10/09/2024
  Compensation
  Class A Common Stock
  06/26/2023
  Compensation
  Issuer
  N
  811
  06/26/2023
  Compensation
  Class A Common Stock
  06/27/2022
  Compensation
  Issuer
  N
  693
  06/27/2022
  Compensation
  Y
  04/29/2025
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Dennis Suskind