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        <issuerAddress>
          <com:street1>700 SAGINAW DR</com:street1>
          <com:city>REDWOOD CITY</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94063</com:zipCode>
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        <issuerContactPhone>415-766-3638</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Cislini Jeff</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
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          <name>Morgan Stanley Wealth Management</name>
          <address>
            <com:street1>The Silicon Valley Group</com:street1>
            <com:street2>2775 Sand Hill Road, Suite 120</com:street2>
            <com:city>Menlo Park</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94025</com:zipCode>
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        <aggregateMarketValue>38565.00</aggregateMarketValue>
        <noOfUnitsOutstanding>106313250</noOfUnitsOutstanding>
        <approxSaleDate>07/31/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <natureOfAcquisitionTransaction>Restricted stock unit grant</natureOfAcquisitionTransaction>
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        <amountOfSecuritiesAcquired>152</amountOfSecuritiesAcquired>
        <paymentDate>03/04/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/01/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted stock unit grant</natureOfAcquisitionTransaction>
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        <amountOfSecuritiesAcquired>337</amountOfSecuritiesAcquired>
        <paymentDate>03/01/2022</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
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      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>09/01/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Restricted stock unit grant</natureOfAcquisitionTransaction>
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        <isGiftTransaction>N</isGiftTransaction>
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            <com:street1>c/o Revolution Medicines, Inc.</com:street1>
            <com:street2>700 Saginaw Drive</com:street2>
            <com:city>Redwood City</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94063</com:zipCode>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>06/20/2023</saleDate>
        <amountOfSecuritiesSold>1239</amountOfSecuritiesSold>
        <grossProceeds>31148.46</grossProceeds>
      </securitiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>07/31/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/27/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>Jeff Cislini</signature>
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text: 144
  0001969082
  XXXXXXXX
  LIVE
  0001628171
  Revolution Medicines, Inc.
  001-39219
  700 SAGINAW DR
  REDWOOD CITY
  CA
  94063
  415-766-3638
  Cislini Jeff
  Officer
  Common Stock
  Morgan Stanley Wealth Management
  The Silicon Valley Group
  2775 Sand Hill Road, Suite 120
  Menlo Park
  CA
  94025
  1500
  38565.00
  106313250
  07/31/2023
  NASDAQ
  Common Stock
  06/17/2020
  Restricted stock unit grant
  Revolution Medicines, Inc.
  N
  669
  06/17/2020
  N/A
  Common Stock
  03/04/2021
  Restricted stock unit grant
  Revolution Medicines, Inc.
  N
  152
  03/04/2021
  N/A
  Common Stock
  03/01/2022
  Restricted stock unit grant
  Revolution Medicines, Inc.
  N
  337
  03/01/2022
  N/A
  Common Stock
  09/01/2022
  Restricted stock unit grant
  Revolution Medicines, Inc.
  N
  342
  09/01/2022
  N/A
  N
  Jeff Cislini
  c/o Revolution Medicines, Inc.
  700 Saginaw Drive
  Redwood City
  CA
  94063
  Common Stock
  06/20/2023
  1239
  31148.46
  07/31/2023
  03/27/2023
  Jeff Cislini