content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001643085</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001582313</issuerCik>
  <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
  <secFileNumber>001-36687</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">200-3650 Gilmore Way</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Burnaby</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A1</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V5G 4W8</zipCode>
  </issuerAddress>
  <issuerContactPhone>(604)-484-3300</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEVEN GANNON</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>RBC Wealth Management</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1501 ave. McGill College</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 2150</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Montreal</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">Z4</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">H3A 3M8</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>13000</noOfUnitsSold>
  <aggregateMarketValue>600310</aggregateMarketValue>
  <noOfUnitsOutstanding>75432482</noOfUnitsOutstanding>
  <approxSaleDate>03/07/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <acquiredDate>08/11/2017</acquiredDate>
  <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Open Market Purchase</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>15000</amountOfSecuritiesAcquired>
  <paymentDate>08/11/2017</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>03/07/2024</noticeDate>
  <signature>/s/ Steve Gannon</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2744}]
text: 144
  0001643085
  XXXXXXXX
  LIVE
  0001582313
  Xenon Pharmaceuticals Inc.
  001-36687
  200-3650 Gilmore Way
  Burnaby
  A1
  V5G 4W8
  (604)-484-3300
  STEVEN GANNON
  Director
  Common Shares
  RBC Wealth Management
  1501 ave. McGill College
  Suite 2150
  Montreal
  Z4
  H3A 3M8
  13000
  600310
  75432482
  03/07/2024
  NASDAQ
  Common Shares
  08/11/2017
  Open Market Purchase
  Open Market Purchase
  N
  15000
  08/11/2017
  Cash
  Y
  03/07/2024
  /s/ Steve Gannon