content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
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  <submissionType>144</submissionType>
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  <filer>
  <filerCredentials>
  <cik>0001462808</cik>
  <ccc>XXXXXXXX</ccc>
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  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
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  <issuerInfo>
  <issuerCik>0001628171</issuerCik>
  <issuerName>Revolution Medicines, Inc.</issuerName>
  <secFileNumber>001-39219</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">700 Saginaw Drive								</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Redwood City			</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">94063</zipCode>
  </issuerAddress>
  <issuerContactPhone>650-481-6801</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Stephen Michael Kelsey								</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>ETRADE FINANCIAL CORPORATION</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 EDISON DRIVE</street1>
  <city xmlns="http://www.sec.gov/edgar/common">ALPHARETTA</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>2102</noOfUnitsSold>
  <aggregateMarketValue>53979.36</aggregateMarketValue>
  <noOfUnitsOutstanding>106313250</noOfUnitsOutstanding>
  <approxSaleDate>06/20/2023</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>06/15/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Vesting of restricted stock units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2102</amountOfSecuritiesAcquired>
  <paymentDate>06/15/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>06/20/2023</noticeDate>
  <signature>/s/ Stephen Michael Kelsey</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
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text: 144
  0001462808
  XXXXXXXX
  LIVE
  0001628171
  Revolution Medicines, Inc.
  001-39219
  700 Saginaw Drive
  Redwood City
  CA
  94063
  650-481-6801
  Stephen Michael Kelsey
  Officer
  Common Stock
  ETRADE FINANCIAL CORPORATION
  3 EDISON DRIVE
  ALPHARETTA
  GA
  30005
  2102
  53979.36
  106313250
  06/20/2023
  NASDAQ
  Common Stock
  06/15/2023
  Vesting of restricted stock units
  Issuer
  N
  2102
  06/15/2023
  N/A
  Y
  06/20/2023
  /s/ Stephen Michael Kelsey