content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001789545</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001818794</issuerCik>
  <issuerName>Dyne Therapeutics, Inc.</issuerName>
  <secFileNumber>001-39509</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </issuerAddress>
  <issuerContactPhone>(781)-786-8230</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Richard Scalzo</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Stifel Financial Corporation</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 Bryant Park, 4th Floor</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">1095 Avenue of the Americas</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10036</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>1872</noOfUnitsSold>
  <aggregateMarketValue>22475</aggregateMarketValue>
  <noOfUnitsOutstanding>61375598</noOfUnitsOutstanding>
  <approxSaleDate>12/06/2023</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/10/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>987</amountOfSecuritiesAcquired>
  <paymentDate>09/10/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/17/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>885</amountOfSecuritiesAcquired>
  <paymentDate>09/17/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Richard Scalzo</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>09/12/2023</saleDate>
  <amountOfSecuritiesSold>1397</amountOfSecuritiesSold>
  <grossProceeds>14543</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Richard Scalzo</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>09/18/2023</saleDate>
  <amountOfSecuritiesSold>1290</amountOfSecuritiesSold>
  <grossProceeds>12139</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Richard Scalzo</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>12/04/2023</saleDate>
  <amountOfSecuritiesSold>681</amountOfSecuritiesSold>
  <grossProceeds>8177</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>The sales reported in this Form 144 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 11, 2023. Securities sold on September 12, 2023 and September 18, 2023 represent shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on September 17, 2020, December 10, 2021 and December 9, 2022. The sale reported for December 4, 2023 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 11, 2023.</remarks>
  <noticeSignature>
  <noticeDate>12/06/2023</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>07/11/2023</planAdoptionDate>
  </planAdoptionDates>
  <signature>/s/ Richard Scalzo</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5900}]
text: 144
  0001789545
  XXXXXXXX
  LIVE
  0001818794
  Dyne Therapeutics, Inc.
  001-39509
  1560 Trapelo Road
  Waltham
  MA
  02451
  (781)-786-8230
  Richard Scalzo
  Officer
  Common Stock
  Stifel Financial Corporation
  3 Bryant Park, 4th Floor
  1095 Avenue of the Americas
  New York
  NY
  10036
  1872
  22475
  61375598
  12/06/2023
  NASDAQ
  Common Stock
  09/10/2023
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  987
  09/10/2023
  N/A
  Common Stock
  09/17/2023
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  885
  09/17/2023
  N/A
  N
  Richard Scalzo
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  09/12/2023
  1397
  14543
  Richard Scalzo
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  09/18/2023
  1290
  12139
  Richard Scalzo
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  12/04/2023
  681
  8177
  The sales reported in this Form 144 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 11, 2023. Securities sold on September 12, 2023 and September 18, 2023 represent shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on September 17, 2020, December 10, 2021 and December 9, 2022. The sale reported for December 4, 2023 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 11, 2023.
  12/06/2023
  07/11/2023
  /s/ Richard Scalzo