content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
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  <submissionType>144</submissionType>
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  <filer>
  <filerCredentials>
  <cik>0001528826</cik>
  <ccc>XXXXXXXX</ccc>
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  <liveTestFlag>LIVE</liveTestFlag>
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  <issuerInfo>
  <issuerCik>0001818794</issuerCik>
  <issuerName>Dyne Therapeutics, Inc.</issuerName>
  <secFileNumber>001-39509</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </issuerAddress>
  <issuerContactPhone>781-786-8230</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Joshua Brumm</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>CEO and President</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>E*Trade Financial Corporation</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 Edison Drive</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Alpharaetta</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>12032</noOfUnitsSold>
  <aggregateMarketValue>113221.00</aggregateMarketValue>
  <noOfUnitsOutstanding>61020486</noOfUnitsOutstanding>
  <approxSaleDate>09/18/2023</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/17/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>12032</amountOfSecuritiesAcquired>
  <paymentDate>09/17/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Joshua Brumm</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>09/12/2023</saleDate>
  <amountOfSecuritiesSold>7672</amountOfSecuritiesSold>
  <grossProceeds>79871.00</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>Sale represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on September 17, 2020.</remarks>
  <noticeSignature>
  <noticeDate>09/18/2023</noticeDate>
  <signature>/s/ Richard Scalzo, Attorney-in-Fact</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
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text: 144
  0001528826
  XXXXXXXX
  LIVE
  0001818794
  Dyne Therapeutics, Inc.
  001-39509
  1560 Trapelo Road
  Waltham
  MA
  02451
  781-786-8230
  Joshua Brumm
  CEO and President
  Common Stock
  E*Trade Financial Corporation
  3 Edison Drive
  Alpharaetta
  GA
  30005
  12032
  113221.00
  61020486
  09/18/2023
  NASDAQ
  Common Stock
  09/17/2023
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  12032
  09/17/2023
  N/A
  N
  Joshua Brumm
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  09/12/2023
  7672
  79871.00
  Sale represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on September 17, 2020.
  09/18/2023
  /s/ Richard Scalzo, Attorney-in-Fact