content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0002029477</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001861560</issuerCik>
  <issuerName>Nuvalent, Inc.</issuerName>
  <secFileNumber>001-40671</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">One Broadway, 14th Floor</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Cambridge</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02142</zipCode>
  </issuerAddress>
  <issuerContactPhone>857-357-7000</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Henry E. Pelish</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1585 Broadway</street1>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10036</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>2750</noOfUnitsSold>
  <aggregateMarketValue>222145</aggregateMarketValue>
  <noOfUnitsOutstanding>65617305</noOfUnitsOutstanding>
  <approxSaleDate>01/06/2025</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
  <acquiredDate>01/05/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2750</amountOfSecuritiesAcquired>
  <paymentDate>01/05/2025</paymentDate>
  <natureOfPayment>Equity Compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>The sales reported on this Form 144 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units.  These sales do not represent discretionary trades by the Reporting Person.</remarks>
  <noticeSignature>
  <noticeDate>01/06/2025</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>12/06/2023</planAdoptionDate>
  </planAdoptionDates>
  <signature>Henry E. Pelish</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3057}]
text: 144
  0002029477
  XXXXXXXX
  LIVE
  0001861560
  Nuvalent, Inc.
  001-40671
  One Broadway, 14th Floor
  Cambridge
  MA
  02142
  857-357-7000
  Henry E. Pelish
  Officer
  Class A Common Stock
  Morgan Stanley
  1585 Broadway
  New York
  NY
  10036
  2750
  222145
  65617305
  01/06/2025
  NASDAQ
  Class A Common Stock
  01/05/2024
  Restricted Stock Unit Vesting
  Issuer
  N
  2750
  01/05/2025
  Equity Compensation
  Y
  The sales reported on this Form 144 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units.  These sales do not represent discretionary trades by the Reporting Person.
  01/06/2025
  12/06/2023
  Henry E. Pelish