content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0000948252</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001320414</issuerCik>
        <issuerName>Select Medical Holdings Corporation</issuerName>
        <secFileNumber>001-34465</secFileNumber>
        <issuerAddress>
          <com:street1>4714 Gettysburg Road</com:street1>
          <com:city>Mechanicsburg</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>17055</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>717-972-1100</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Rocco A.  Ortenzio Separate Exempt Descendants Trust</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3804805</noOfUnitsSold>
        <aggregateMarketValue>79292136.2</aggregateMarketValue>
        <noOfUnitsOutstanding>129466933</noOfUnitsOutstanding>
        <approxSaleDate>11/26/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/29/2007</acquiredDate>
        <natureOfAcquisitionTransaction>Gifts</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Rocco A. Ortenzio Descendants Trust</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3804805</amountOfSecuritiesAcquired>
        <paymentDate>03/29/2007</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The shares represented on this filing were gifted during 08/27/07 - 08/25/20.</remarks>
      <noticeSignature>
        <noticeDate>11/26/2024</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Rocco A.  Ortenzio Separate Exempt Descendants Trust</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3028}]
text: 144
  0000948252
  XXXXXXXX
  LIVE
  0001320414
  Select Medical Holdings Corporation
  001-34465
  4714 Gettysburg Road
  Mechanicsburg
  PA
  17055
  717-972-1100
  Rocco A.  Ortenzio Separate Exempt Descendants Trust
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  3804805
  79292136.2
  129466933
  11/26/2024
  NYSE
  Common
  03/29/2007
  Gifts
  Rocco A. Ortenzio Descendants Trust
  N
  3804805
  03/29/2007
  N/A
  Y
  The shares represented on this filing were gifted during 08/27/07 - 08/25/20.
  11/26/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Rocco A.  Ortenzio Separate Exempt Descendants Trust