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  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">OMB APPROVAL</div>
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  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 11pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">SECURITIES AND EXCHANGE COMMISSION</div>
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  <td style="BORDER-LEFT: black 2px solid; WIDTH: 2%; FONT-FAMILY: times new roman; FONT-SIZE: 8pt" valign="top" nowrap align="left">&#160;OMB Number:</td>
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  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 11pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">Washington, D.C. 20549</div>
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  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 8pt; MARGIN-RIGHT: 0pt">&#160;Expires:</div>
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  <div style="TEXT-ALIGN: right; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt"><font style="FONT-FAMILY: times new roman; FONT-SIZE: 8pt">June&#160;30, 2020&#160;</font> </div>
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  <td style="BORDER-LEFT: black 2px solid; WIDTH: 14%; BORDER-RIGHT: black 2px solid" valign="bottom" colspan="3" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 8pt; MARGIN-RIGHT: 0pt"><font style="FONT-FAMILY: times new roman; FONT-SIZE: 8pt">&#160;Estimated</font> average burden</div>
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  <div style="TEXT-ALIGN: center; LINE-HEIGHT: 1.25; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 14pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">FORM 144</div>
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  <div style="TEXT-ALIGN: right; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt"><font style="FONT-FAMILY: times new roman; FONT-SIZE: 8pt">1.00&#160;</font> </div>
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  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 11pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">NOTICE OF PROPOSED SALE OF SECURITIES</div>
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  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 8pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">SEC USE ONLY</div>
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  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 11pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933</div>
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  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 14%; BORDER-RIGHT: black 2px solid" bgcolor="gainsboro" valign="top" colspan="3" align="left">&#160;</td>
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  <td style="WIDTH: 80%" valign="top" colspan="7">&#160;</td>
  <td style="BORDER-LEFT: black 2px solid; WIDTH: 14%; BORDER-RIGHT: black 2px solid" bgcolor="gainsboro" valign="top" colspan="3" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 8pt; MARGIN-RIGHT: 0pt">&#160;CUSIP NUMBER</div>
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  <div style="TEXT-ALIGN: left; TEXT-INDENT: -63pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 63pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 11pt; FONT-WEIGHT: bold">ATTENTION: </font><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-SIZE: 10pt">Transmit for filing 3 copies of this form concurrently with either placing an order with a broker to execute sale</font><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: times new roman">&#160;</font><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-SIZE: 10pt">or executing a sale directly with a market maker.</font></div>
  
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  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">&#160;1<font style="FONT-STYLE: italic; DISPLAY: inline"> (a)</font> <font style="FONT-FAMILY: times new roman; FONT-SIZE: 10pt">NAME</font> OF ISSUER <font style="FONT-STYLE: italic">(Please type or print)</font></div>
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  <td style="BORDER-LEFT: black 2px solid; WIDTH: 15%; BORDER-RIGHT: black 2px solid" valign="top" align="left">
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  <td style="WIDTH: 21%" valign="top" colspan="2" align="left">
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  <div style="FONT-FAMILY: times new roman; FONT-SIZE: 11pt">&#160;</div>
  
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  <td style="BORDER-LEFT: black 2px solid; WIDTH: 24%" valign="top" align="left">
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  <td style="BORDER-LEFT: medium none; WIDTH: 15%; BORDER-RIGHT: medium none" valign="top" align="left">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">CITY</div>
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  <td style="BORDER-LEFT: medium none; WIDTH: 10%" valign="top" align="left">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">STATE</div>
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  <td style="BORDER-LEFT: medium none; WIDTH: 20%; FONT-FAMILY: times new roman; FONT-SIZE: 11pt; BORDER-RIGHT: medium none" valign="top" colspan="3" align="left">&#160;</td>
  <td style="BORDER-LEFT: medium none; WIDTH: 15%; BORDER-RIGHT: medium none" valign="top" align="left">&#160;</td>
  <td style="WIDTH: 10%" valign="top">&#160;</td>
  <td style="WIDTH: 11%; FONT-FAMILY: times new roman; FONT-SIZE: 11pt" valign="top">&#160;</td>
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  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 24%" valign="top" colspan="4" align="left">&#160;<font style="FONT-FAMILY: times new roman; FONT-SIZE: 10pt"><font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">131 Oyster Point Blvd, Suite 600</font></td>
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">CA</div>
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  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%" valign="top">
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  <div style="MARGIN-LEFT: 9pt">&#160;2 <font style="FONT-STYLE: italic; DISPLAY: inline">(a)</font> NAME OF PERSON FOR WHOSE ACCOUNT THE<br>
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  <td style="WIDTH: 11%; BORDER-TOP: medium none" valign="top" align="left">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">CITY</div>
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  <td style="BORDER-LEFT: medium none; WIDTH: 6%; BORDER-TOP: medium none" valign="top" align="left">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: -18pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 18pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">STATE</div>
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  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">ZIP CODE</div>
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  <td style="BORDER-LEFT: medium none; WIDTH: 8%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; BORDER-TOP: medium none; BORDER-RIGHT: black 2px solid" valign="top" align="left">&#160;</td>
  <td style="WIDTH: 12%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; BORDER-TOP: medium none; BORDER-RIGHT: black 2px solid" valign="top" align="left">&#160;</td>
  <td style="WIDTH: 25%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; BORDER-TOP: medium none" valign="top" colspan="2" align="left">&#160;</td>
  <td style="WIDTH: 11%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; BORDER-TOP: medium none" valign="top" align="left">&#160;</td>
  <td style="BORDER-LEFT: medium none; WIDTH: 6%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; BORDER-TOP: medium none" valign="top" align="left">&#160;</td>
  <td style="WIDTH: 8%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; BORDER-TOP: medium none; BORDER-RIGHT: black 2px solid" valign="top" colspan="2" align="left">&#160;</td>
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  <td style="BORDER-LEFT: black 2px solid; WIDTH: 24%; FONT-SIZE: 12pt; BORDER-RIGHT: black 2px solid" valign="middle" colspan="2">
  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; TEXT-INDENT: 0pt; FONT-FAMILY: 'Times New Roman', serif; COLOR: #000000; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt; FONT-SIZE: 8pt"><font style="FONT-SIZE: 10pt">OrbiMed
  Advisors LLC on behalf of OrbiMed Private Investments IV &ndash; AL (Feeder), LP</div>
  </td>
  <td style="text-align: left; border-left-style: none; border-left-width: medium; width: 8%; border-right: black 2px solid; vertical-align: middle">
  <div style="font-family: Times New Roman; color: #000000">33-1229659</div></td>
  <td style="WIDTH: 12%; FONT-SIZE: 10pt; BORDER-RIGHT: black 2px solid" valign="middle" align="left">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman'; COLOR: #000000">Shareholder</div>
  </td>
  <td style="PADDING-LEFT: 0pt; WIDTH: 25%; MARGIN-LEFT: 9pt; FONT-SIZE: 10pt" valign="middle" colspan="2" align="left">
  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 8pt"><font style="FONT-SIZE: 10pt">c/o OrbiMed Advisors LLC</font>
  
  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">601 Lexington Avenue, 54th Floor</div>
  </div>
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  <td style="WIDTH: 11%; FONT-SIZE: 10pt" valign="middle" align="left">
  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">New York</div>
  </td>
  <td style="BORDER-LEFT: medium none; WIDTH: 6%; FONT-SIZE: 10pt" valign="middle" align="left">
  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000">NY</div>
  </td>
  <td style="WIDTH: 8%; FONT-SIZE: 10pt; BORDER-RIGHT: black 2px solid" valign="middle" colspan="2" align="left">
  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 8pt">10022</div>
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  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: medium none; WIDTH: 8%; BORDER-RIGHT: black 2px solid" valign="bottom" align="left">&#160;</td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 12%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; BORDER-RIGHT: black 2px solid" valign="middle" align="left">&#160;</td>
  <td style="BORDER-BOTTOM: black 2px solid; PADDING-LEFT: 0pt; WIDTH: 25%; FONT-FAMILY: times new roman; MARGIN-LEFT: 9pt; FONT-SIZE: 11pt" valign="middle" colspan="2" align="left">&#160;</td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" valign="middle" align="left">&#160;</td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: medium none; WIDTH: 6%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" valign="middle" align="left">&#160;</td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 8%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; BORDER-RIGHT: black 2px solid" valign="middle" colspan="2" align="left">&#160;</td>
  </tr>
  </table>
  </div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block"><br>
  <font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 10pt">INSTRUCTION:&#160;&#160;The person filing this notice should contact the issuer to obtain the I.R.S. Identification Number and the S.E.C. File Number.</font></div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt">&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" id="z582bc80eb39c49aa81889cd1182f4287" cellspacing="0" cellpadding="2">
  <tr>
  <td style="BORDER-LEFT: black 2px solid; PADDING-BOTTOM: 2px; WIDTH: 11%; BORDER-TOP: black 2px solid" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">&#160; 3 (<font style="FONT-STYLE: italic; DISPLAY: inline">a)</font></div>
  </td>
  <td style="BORDER-LEFT: black 2px solid; PADDING-BOTTOM: 2px; WIDTH: 23%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="top" align="left">
  <div style="TEXT-ALIGN: left; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">&#160; (b)</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%; BORDER-TOP: black 2px solid" valign="top" align="left">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">SEC USE ONLY</div>
  </td>
  <td style="BORDER-LEFT: black 2px solid; PADDING-BOTTOM: 2px; WIDTH: 11%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="top" align="left">
  <div style="TEXT-ALIGN: left; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">&#160; (c)</div>
  </td>
  <td style="PADDING-BOTTOM: 2px; WIDTH: 11%; BORDER-TOP: black 2px solid" valign="top" align="left">
  <div style="TEXT-ALIGN: left; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">&#160; (d)</div>
  </td>
  <td style="BORDER-LEFT: black 2px solid; PADDING-BOTTOM: 2px; WIDTH: 11%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="top" align="left">
  <div style="TEXT-ALIGN: left; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">&#160; (e)</div>
  </td>
  <td style="PADDING-BOTTOM: 2px; WIDTH: 11%; BORDER-TOP: black 2px solid" valign="top" align="left">
  <div style="TEXT-ALIGN: left; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">&#160; (f)</div>
  </td>
  <td style="BORDER-LEFT: black 2px solid; PADDING-BOTTOM: 2px; WIDTH: 11%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="top" align="left">
  <div style="TEXT-ALIGN: left; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">&#160; (g)</div>
  </td>
  </tr>
  
  <tr>
  <td style="BORDER-LEFT: black 2px solid; WIDTH: 11%" valign="bottom">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">Title of the <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Class <br>
  of <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Securities <br>
  To Be Sold</font></font></div>
  </td>
  <td style="BORDER-LEFT: black 2px solid; WIDTH: 23%; BORDER-RIGHT: black 2px solid" valign="bottom">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">Name and Address of Each Broker Through <br>
  Whom the <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Securities are to be Offered or Each <br>
  Market Maker <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">who is Acquiring the Securities</font></font></div>
  </td>
  <td style="WIDTH: 11%" bgcolor="gainsboro" valign="bottom">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Broker-Dealer </font>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">File Number</div>
  </div>
  </td>
  <td style="BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">Number of Shares <br>
  <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">or Other Units <br>
  <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">To Be Sold</font></font></div>
  </td>
  <td style="WIDTH: 11%" valign="top">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">Aggregate <br>
  <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Market <br>
  <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Value</font></font></div>
  </td>
  <td style="BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="top" align="left">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">Number of Shares <br>
  <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">or Other Units <br>
  <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Outstanding</font></font></div>
  </td>
  <td style="WIDTH: 11%" valign="top" align="left">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">Approximate <br>
  <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Date of Sale</font></div>
  </td>
  <td style="BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">Name of Each <br>
  <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Securities <br>
  <font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold">Exchange</font></font></div>
  </td>
  </tr>
  
  <tr>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 11%" valign="top">&#160;</td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 23%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">&#160;</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" bgcolor="gainsboro" valign="top">&#160; </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="bottom">
  <div style="TEXT-ALIGN: center; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(See instr. 3(c))</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%" valign="bottom">
  <div style="TEXT-ALIGN: center; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(See instr. 3(d))</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="bottom">
  <div style="TEXT-ALIGN: center; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(See instr. 3(e))</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%" valign="top" align="left">
  <div style="TEXT-ALIGN: center; FONT-STYLE: normal; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt"><font style="FONT-STYLE: italic; DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">(See instr. 3(f)) <br>
  </font>(MO. &#160;DAY&#160; YR.)</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="bottom">
  <div style="TEXT-ALIGN: center; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(See instr. 3(g))</div>
  </td>
  </tr>
  
  <tr>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: left; BORDER-LEFT: black 2px solid; PADDING-LEFT: 0pt; WIDTH: 11%; MARGIN-LEFT: 9pt" valign="top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: times new roman; MARGIN-LEFT: 9pt; FONT-SIZE: 10pt">Common</div>
  
  <div style="TEXT-ALIGN: left; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;&#160; </div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: left; BORDER-LEFT: black 2px solid; TEXT-INDENT: 0pt; PADDING-LEFT: 0pt; WIDTH: 23%; MARGIN-LEFT: 9pt; MARGIN-RIGHT: 0pt; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; FONT-FAMILY: 'Times New Roman'; COLOR: #000000; MARGIN-LEFT: 9pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman'; FONT-SIZE: 10pt">Morgan Stanley</div>
  
  <div>
  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">1300 Thames Street</div>
  
  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Thames Street Wharf, 3rd Floor</div>
  
  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">Baltimore, MD 21231</div>
  
  <div style="LINE-HEIGHT: 1.25">&#160;</div>
  </div>
  </div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" bgcolor="gainsboro" valign="top">&#160;</td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman'; COLOR: #000000; FONT-SIZE: 10pt">20,985</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;&#160; </div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%" valign="top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman'; COLOR: #000000; FONT-SIZE: 10pt">$519,376</div>
  
  <div style="LINE-HEIGHT: 1.25">&#160;</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">78,982,116</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">3/27/2020</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">NASDAQ</div>
  
  <div style="TEXT-ALIGN: center">&#160;&#160; </div>
  </td>
  </tr>
  
  <tr>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: left; BORDER-LEFT: black 2px solid; WIDTH: 11%" valign="top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: times new roman; FONT-SIZE: 11pt">&#160;</div>
  
  <font style="FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;&#160;&#160; </font></td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; PADDING-LEFT: 0pt; WIDTH: 23%; BORDER-RIGHT: black 2px solid" valign="top" align="left">
  <div style="FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;</div>
  
  <div style="FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;&#160; </div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" bgcolor="gainsboro" valign="top">&#160;</td>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: center; BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;</div>
  
  <div style="FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;&#160; </div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: center; WIDTH: 11%" valign="top">
  <div style="FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;</div>
  
  <div style="FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;&#160; </div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;&#160; </div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 11%" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;&#160; </div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 11%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">&#160;</div>
  
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 11pt">&#160;&#160;&#160;&#160;&#160;&#160;&#160; </div>
  </td>
  </tr>
  </table>
  </div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" id="zf1476b13236d45989d29102ae4d28ad4" cellspacing="0" cellpadding="0">
  <tr>
  <td style="WIDTH: 38%" valign="top" colspan="3" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">INSTRUCTIONS:</div>
  </td>
  <td style="WIDTH: 1%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt">&#160;</div>
  </td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt">&#160;</div>
  </td>
  <td style="WIDTH: 57%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt">&#160;</div>
  </td>
  </tr>
  
  <tr>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">1.</div>
  </td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(a)</div>
  </td>
  <td style="WIDTH: 34%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Name of issuer</div>
  </td>
  <td style="WIDTH: 1%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">3.</div>
  </td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(a)</div>
  </td>
  <td style="WIDTH: 57%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Title of the class of securities to be sold</div>
  </td>
  </tr>
  
  <tr>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(b)</div>
  </td>
  <td style="WIDTH: 34%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Issuer&#8217;s I.R.S. Identification Number</div>
  </td>
  <td style="WIDTH: 1%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(b)</div>
  </td>
  <td style="WIDTH: 57%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Name and address of each broker through whom the securities are intended to be sold</div>
  </td>
  </tr>
  
  <tr>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(c)</div>
  </td>
  <td style="WIDTH: 34%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Issuer&#8217;s S.E.C. file number, if any</div>
  </td>
  <td style="WIDTH: 1%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(c)</div>
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  <td style="WIDTH: 57%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Number of shares or other units to be sold (if debt securities, give the aggregate face amount)</div>
  </td>
  </tr>
  
  <tr>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(d)</div>
  </td>
  <td style="WIDTH: 34%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Issuer&#8217;s address, including zip code</div>
  </td>
  <td style="WIDTH: 1%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(d)</div>
  </td>
  <td style="WIDTH: 57%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Aggregate market value of the securities to be sold as of a specified date within 10 days prior to filing of this notice</div>
  </td>
  </tr>
  
  <tr>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(e)</div>
  </td>
  <td style="WIDTH: 34%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Issuer&#8217;s telephone number, including area code</div>
  </td>
  <td style="WIDTH: 1%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(e)</div>
  </td>
  <td style="WIDTH: 57%" valign="top">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Number of shares or other units of the class outstanding, or if debt securities the face amount thereof outstanding, as shown by the most recent report or statement published by the issuer</div>
  </td>
  </tr>
  
  <tr>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" valign="top">&#160; </td>
  <td style="WIDTH: 34%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" valign="top">&#160; </td>
  <td style="WIDTH: 1%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(f)</div>
  </td>
  <td style="WIDTH: 57%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Approximate date on which the securities are to be sold</div>
  </td>
  </tr>
  
  <tr>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">2.</div>
  </td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(a)</div>
  </td>
  <td style="WIDTH: 35%" valign="top" colspan="2" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Name of person for whose account the securities are to be sold</div>
  </td>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(g)</div>
  </td>
  <td style="WIDTH: 57%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Name of each securities exchange, if any, on which the securities are intended to be sold</div>
  </td>
  </tr>
  
  <tr>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(b)</div>
  </td>
  <td style="WIDTH: 35%" valign="top" colspan="2" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Such person&#8217;s relationship to the issuer (e.g., officer, director, 10% stockholder, or member of immediate family of any of the foregoing)</div>
  </td>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt">&#160;</div>
  </td>
  <td style="WIDTH: 57%" valign="top">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt">&#160;</div>
  </td>
  </tr>
  
  <tr>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(c)</div>
  </td>
  <td style="WIDTH: 35%" valign="top" colspan="2" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Such person&#8217;s address, including zip code</div>
  </td>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 57%" valign="top">&#160;</td>
  </tr>
  </table>
  </div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" id="z2a61ba711acf4e7cb5c457ede9739a8b" cellspacing="0" cellpadding="0">
  <tr>
  <td style="TEXT-ALIGN: center; WIDTH: 90%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; FONT-WEIGHT: bold" valign="top">Potential persons who are to respond to the collection of information contained in this form are not&#160;<br>
  required to respond unless the form displays a currently valid OMB control number.</td>
  <td style="WIDTH: 10%" valign="top">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">SEC 1147 (08-07)</div>
  </td>
  </tr>
  </table>
  </div>
  
  <div style="TEXT-ALIGN: left">&#160;</div>
  
  <div style="MARGIN-TOP: 10pt; MARGIN-BOTTOM: 10pt; CLEAR: both" id="DSPFPageBreakArea">
  <div style="PAGE-BREAK-AFTER: always" id="DSPFPageBreak">
  <hr style="BORDER-RIGHT-WIDTH: 0px; BACKGROUND-COLOR: #000000; MARGIN: 4px 0px; WIDTH: 100%; BORDER-TOP-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; HEIGHT: 2px; COLOR: #000000; CLEAR: both; BORDER-LEFT-WIDTH: 0px" noshade>
  </div>
  </div>
  
  <div style="TEXT-INDENT: 0pt; DISPLAY: block">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; FONT-FAMILY: Times New Roman; MARGIN-LEFT: 0pt; FONT-SIZE: 14pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt" id="PGBRK">TABLE I &#8212; SECURITIES TO BE SOLD</div>
  
  <div>
  <div style="TEXT-ALIGN: center; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: Times New Roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Furnish the following information with respect to the acquisition of the securities to be sold</div>
  
  <div style="TEXT-ALIGN: center; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: Times New Roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">and with respect to the payment of all or any part of the purchase price or other consideration therefor:</div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt">&#160;</div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" id="zd8c117fadccb41aaa31c3da65f584635" cellspacing="0" cellpadding="2">
  <tr>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 12%; BORDER-TOP: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Title of</div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">the Class</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 12%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Date you</div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Acquired</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 22%; BORDER-TOP: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Nature of Acquisition Transaction</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 22%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Name of Person from Whom Acquired</div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">(<font style="FONT-STYLE: italic">If gift, also give date donor acquired</font>)</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 12%; BORDER-TOP: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Amount of</div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Securities Acquired</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 8%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Date of</div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Payment</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 12%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Nature of Payment</div>
  </td>
  </tr>
  
  <tr>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: left; BORDER-LEFT: black 2px solid; PADDING-LEFT: 0pt; WIDTH: 12%; MARGIN-LEFT: 9pt" valign="top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: times new roman; MARGIN-LEFT: 9pt; FONT-SIZE: 10pt">Common Stock</div>
  
  <div style="TEXT-ALIGN: left">&#160;</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: center; BORDER-LEFT: black 2px solid; WIDTH: 12%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">
  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; FONT-FAMILY: 'Times New Roman', Times, serif; COLOR: #000000; FONT-SIZE: 10pt">More than
  1 year</div>
  
  <div style="LINE-HEIGHT: 1.25">&#160;</div>
  </div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: left; WIDTH: 22%" valign="top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: 'Times New Roman'; COLOR: #000000; FONT-SIZE: 10pt">Private Placement</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: left; BORDER-LEFT: black 2px solid; WIDTH: 22%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">Issuer</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 12%" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: 'Times New Roman'; COLOR: #000000; FONT-SIZE: 10pt">20,985</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 8%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">More than 1
  year</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 12%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">Cash</div>
  </td>
  </tr>
  </table>
  </div>
  <br>
  
  <div style="TEXT-INDENT: 0pt; DISPLAY: block"><br>
  <br>
  </div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" id="z520ad5ca599c4320ba90cee08a8464af" cellspacing="0" cellpadding="0">
  <tr>
  <td style="WIDTH: 6%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 11pt; FONT-WEIGHT: bold; MARGIN-RIGHT: 0pt">INSTRUCTIONS:</div>
  </td>
  <td style="WIDTH: 2%" valign="top">&#160;</td>
  <td style="WIDTH: 48%" valign="top">
  <div style="TEXT-ALIGN: justify; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">I</font><font style="DISPLAY: inline; FONT-SIZE: 10pt">f the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.</font></div>
  </td>
  </tr>
  </table>
  </div>
  
  <div style="TEXT-INDENT: 0pt; DISPLAY: block"><br>
  <br>
  </div>
  
  <div style="TEXT-INDENT: 0pt; DISPLAY: block">
  <hr style="WIDTH: 100%; COLOR: black" align="left" size="4">
  </div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; MARGIN-LEFT: 0pt; MARGIN-RIGHT: 0pt"><font style="DISPLAY: inline; FONT-FAMILY: Times New Roman; FONT-SIZE: 14pt; FONT-WEIGHT: bold">TABLE II &#8212; SECURITIES SOLD DURING THE PAST 3 MONTHS</font><br>
  <br>
  </div>
  
  <div style="TEXT-ALIGN: center; FONT-STYLE: italic; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: Times New Roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.</div>
  
  <div style="TEXT-INDENT: 0pt; DISPLAY: block"><br>
  <br>
  </div>
  
  <div style="TEXT-ALIGN: left">
  <table style="WIDTH: 100%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" id="z7a7735248e374d799c898208cbcdb0d4" cellspacing="0" cellpadding="2">
  <tr>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 35%; BORDER-TOP: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Name and Address of Seller</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 25%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Title of Securities Sold</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 10%; BORDER-TOP: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Date of Sale</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; WIDTH: 13%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Amount of</div>
  
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Securities Sold</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; WIDTH: 17%; BORDER-TOP: black 2px solid; BORDER-RIGHT: black 2px solid" valign="middle">
  <div style="TEXT-ALIGN: center; TEXT-INDENT: 0pt; DISPLAY: block; FONT-FAMILY: times new roman; MARGIN-LEFT: 0pt; FONT-SIZE: 10pt; MARGIN-RIGHT: 0pt">Gross Proceeds</div>
  </td>
  </tr>
  
  <tr>
  <td style="BORDER-BOTTOM: black 2px solid; BORDER-LEFT: black 2px solid; PADDING-LEFT: 0pt; WIDTH: 26%" valign="top" align="left">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: times new roman; MARGIN-LEFT: 9pt; FONT-SIZE: 10pt">OrbiMed Private Investments IV &ndash; AL (Feeder), LP<br>
  c/o OrbiMed Advisors LLC<br>
  601 Lexington Avenue, 54th Floor<br>
  New York, NY 10022
  </div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: left; BORDER-LEFT: black 2px solid; WIDTH: 25%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="TEXT-ALIGN: left; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">Common Stock</div>
  </td>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: center; WIDTH: 10%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" valign="top">12/24/19<br>
  12/26/19<br>
  1/9/20<br>
  3/2/20<br>
  3/23/20<br>
  3/24/20<br>
  3/25/20<br>
  
  &#160; </td>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: center; BORDER-LEFT: black 2px solid; WIDTH: 13%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt; BORDER-RIGHT: black 2px solid" valign="top">15,476<br>
  2,325<br>
  91,818<br>
  445,086<br>
  3,541<br>
  16,409<br>
  13,684<br>
  
  &#160;&#160; </td>
  <td style="BORDER-BOTTOM: black 2px solid; TEXT-ALIGN: center; WIDTH: 17%; BORDER-RIGHT: black 2px solid" valign="top">
  <div style="FONT-FAMILY: times new roman; FONT-SIZE: 10pt">$303,214<br>
  $43,247<br>
  $1,790,457<br>
  $11,572,980<br>
  $92,230<br>
  $401,166<br>
  $337,454
  </div>
  
  <div>&#160;</div>
  </td>
  </tr>
  </table>
  </div>
  <br>
  
  
  
  
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  <div style="TEXT-ALIGN: center; FONT-FAMILY: times new roman; FONT-SIZE: 10pt">3/27/2020</div>
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  <td style="TEXT-ALIGN: center; WIDTH: 40%; FONT-FAMILY: times new roman; FONT-SIZE: 10pt" valign="top">(SIGNATURE)</td>
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  IF RELYING ON RULE 10B5-1</div>
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  <div style="TEXT-ALIGN: right; TEXT-INDENT: 0pt; DISPLAY: block">SEC 1147 (02-08)</div>
  
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metadata_documents: [{"type": "144", "sequence": "1", "filename": "ss170161_144.htm", "description": "NOTICE OF PROPOSED SALE OF SECURITIES", "secsgml_size_bytes": 66630}]
text: UNITED STATES
  OMB APPROVAL
  SECURITIES AND EXCHANGE COMMISSION
  OMB Number:
  3235-0101
  Washington, D.C. 20549
  Expires:
  June 30, 2020
  Estimated
  average burden
  FORM 144
  hours per response
  1.00
  NOTICE OF PROPOSED SALE OF SECURITIES
  SEC USE ONLY
  PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
  DOCUMENT SEQUENCE NO.
  CUSIP NUMBER
  ATTENTION:
  Transmit for filing 3 copies of this form concurrently with either placing an order with a broker to execute sale
  or executing a sale directly with a market maker.
  1
  (a)
  NAME
  OF ISSUER
  (Please type or print)
  (b)
  IRS IDENT. NO.
  (c)
  S.E.C. FILE NO.
  WORK LOCATION
  Alector, Inc.
  462702363
  001-38792
  1
  (d)
  ADDRESS OF ISSUER
  STREET
  CITY
  STATE
  ZIP
  CODE
  (e)
  TELEPHONE NO.
  AREA CODE
  NUMBER
  131 Oyster Point Blvd, Suite 600
  South San Francisco
  CA
  94080
  415
  231-5660
  2
  (a)
  NAME OF PERSON FOR WHOSE ACCOUNT THE
  SECURITIES ARE TO BE SOLD
  (b)
  IRS IDENT. NO.
  (c)
  RELATIONSHIP TO ISSUER
  (d)
  ADDRESS STREET
  CITY
  STATE
  ZIP CODE
  OrbiMed
  Advisors LLC on behalf of OrbiMed Private Investments IV – AL (Feeder), LP
  33-1229659
  Shareholder
  c/o OrbiMed Advisors LLC
  601 Lexington Avenue, 54th Floor
  New York
  NY
  10022
  INSTRUCTION:  The person filing this notice should contact the issuer to obtain the I.R.S. Identification Number and the S.E.C. File Number.
  3 (
  a)
  (b)
  SEC USE ONLY
  (c)
  (d)
  (e)
  (f)
  (g)
  Title of the
  Class
  of
  Securities
  To Be Sold
  Name and Address of Each Broker Through
  Whom the
  Securities are to be Offered or Each
  Market Maker
  who is Acquiring the Securities
  Broker-Dealer
  File Number
  Number of Shares
  or Other Units
  To Be Sold
  Aggregate
  Market
  Value
  Number of Shares
  or Other Units
  Outstanding
  Approximate
  Date of Sale
  Name of Each
  Securities
  Exchange
  (See instr. 3(c))
  (See instr. 3(d))
  (See instr. 3(e))
  (See instr. 3(f))
  (MO.  DAY  YR.)
  (See instr. 3(g))
  Common
  Morgan Stanley
  1300 Thames Street
  Thames Street Wharf, 3rd Floor
  Baltimore, MD 21231
  20,985
  $519,376
  78,982,116
  3/27/2020
  NASDAQ
  INSTRUCTIONS:
  1.
  (a)
  Name of issuer
  3.
  (a)
  Title of the class of securities to be sold
  (b)
  Issuer's I.R.S. Identification Number
  (b)
  Name and address of each broker through whom the securities are intended to be sold
  (c)
  Issuer's S.E.C. file number, if any
  (c)
  Number of shares or other units to be sold (if debt securities, give the aggregate face amount)
  (d)
  Issuer's address, including zip code
  (d)
  Aggregate market value of the securities to be sold as of a specified date within 10 days prior to filing of this notice
  (e)
  Issuer's telephone number, including area code
  (e)
  Number of shares or other units of the class outstanding, or if debt securities the face amount thereof outstanding, as shown by the most recent report or statement published by the issuer
  (f)
  Approximate date on which the securities are to be sold
  2.
  (a)
  Name of person for whose account the securities are to be sold
  (g)
  Name of each securities exchange, if any, on which the securities are intended to be sold
  (b)
  Such person's relationship to the issuer (e.g., officer, director, 10% stockholder, or member of immediate family of any of the foregoing)
  (c)
  Such person's address, including zip code
  Potential persons who are to respond to the collection of information contained in this form are not
  required to respond unless the form displays a currently valid OMB control number.
  SEC 1147 (08-07)
  TABLE I — SECURITIES TO BE SOLD
  Furnish the following information with respect to the acquisition of the securities to be sold
  and with respect to the payment of all or any part of the purchase price or other consideration therefor:
  Title of
  the Class
  Date you
  Acquired
  Nature of Acquisition Transaction
  Name of Person from Whom Acquired
  (
  If gift, also give date donor acquired
  )
  Amount of
  Securities Acquired
  Date of
  Payment
  Nature of Payment
  Common Stock
  More than
  1 year
  Private Placement
  Issuer
  20,985
  More than 1
  year
  Cash
  INSTRUCTIONS:
  I
  f the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.
  TABLE II — SECURITIES SOLD DURING THE PAST 3 MONTHS
  Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.
  Name and Address of Seller
  Title of Securities Sold
  Date of Sale
  Amount of
  Securities Sold
  Gross Proceeds
  OrbiMed Private Investments IV – AL (Feeder), LP
  c/o OrbiMed Advisors LLC
  601 Lexington Avenue, 54th Floor
  New York, NY 10022
  Common Stock
  12/24/19
  12/26/19
  1/9/20
  3/2/20
  3/23/20
  3/24/20
  3/25/20
  15,476
  2,325
  91,818
  445,086
  3,541
  16,409
  13,684
  $303,214
  $43,247
  $1,790,457
  $11,572,980
  $92,230
  $401,166
  $337,454
  REMARKS:
  INSTRUCTIONS:
  ATTENTION:
  See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
  The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
  3/27/2020
  /s/  Douglas Coon
  DATE OF NOTICE
  (SIGNATURE)
  DATE OF PLAN ADOPTION OR GIVING OF INSTRUCTION,
  IF RELYING ON RULE 10B5-1
  The notice shall be signed by the person for whose account the securities are to be sold. At least one
  copy of the notice shall be manually signed. Any copies not manually signed shall bear typed or printed signatures.
  ATTENTION:
  Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)
  SEC 1147 (02-08)