content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <!-- Field: Pseudo-Tag; ID: Name; Data: MALLIK AMEET -->
            <cik>0001861441</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001771910</issuerCik>
        <issuerName>ADC Therapeutics SA</issuerName>
        <secFileNumber>001-39071</secFileNumber>
        <issuerAddress>
          <com:street1>430 Mountain Ave</com:street1>
          <com:street2>Suite 404</com:street2>
          <com:city>New Providence</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07974</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>908-440-7732</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Ameet Mallik</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer and Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Shares</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Morgan Stanley</name>
          <address>
            <com:street1>1 New York Plaza</com:street1>
            <com:street2>38th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10004</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>29731</noOfUnitsSold>
        <aggregateMarketValue>134194.88</aggregateMarketValue>
        <noOfUnitsOutstanding>82777226</noOfUnitsOutstanding>
        <approxSaleDate>05/07/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Shares</securitiesClassTitle>
        <acquiredDate>05/06/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Vesting of Restricted Share Unit Grant</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ADC Therapeutics SA</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>78125</amountOfSecuritiesAcquired>
        <paymentDate>05/06/2024</paymentDate>
        <natureOfPayment>Vesting of Restricted Stock Unit Grant</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The Reporting Person is selling the securities set forth herein pursuant to an automatic "sell to cover" transaction that did not represent a discretionary trade by the Reporting Person in order to pay the tax liability arising from the vesting and settlement of restricted share units.</remarks>
      <noticeSignature>
        <noticeDate>05/07/2024</noticeDate>
        <signature>/s/ Ameet Mallik</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3250}]
text: 144
  0001861441
  XXXXXXXX
  LIVE
  0001771910
  ADC Therapeutics SA
  001-39071
  430 Mountain Ave
  Suite 404
  New Providence
  NJ
  07974
  908-440-7732
  Ameet Mallik
  Officer and Director
  Common Shares
  Morgan Stanley
  1 New York Plaza
  38th Floor
  New York
  NY
  10004
  29731
  134194.88
  82777226
  05/07/2024
  NYSE
  Common Shares
  05/06/2024
  Vesting of Restricted Share Unit Grant
  ADC Therapeutics SA
  N
  78125
  05/06/2024
  Vesting of Restricted Stock Unit Grant
  Y
  The Reporting Person is selling the securities set forth herein pursuant to an automatic "sell to cover" transaction that did not represent a discretionary trade by the Reporting Person in order to pay the tax liability arising from the vesting and settlement of restricted share units.
  05/07/2024
  /s/ Ameet Mallik