content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001983417</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  
  
  
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001503584</issuerCik>
  <issuerName>Costamare Inc.</issuerName>
  <secFileNumber>001-34934</secFileNumber>
  <issuerAddress>
  <com:street1>7 Rue du Gabian</com:street1>
  <com:city>Monaco</com:city>
  <com:stateOrCountry>O9</com:stateOrCountry>
  <com:zipCode>MC98000</com:zipCode>
  </issuerAddress>
  <issuerContactPhone>37793250940</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Zikos Grigorios</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>CFO</relationshipToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Credit Suisse Securities (USA) LLC</name>
  <address>
  <com:street1>Eleven Madison Avenue</com:street1>
  <com:city>New York</com:city>
  <com:stateOrCountry>NY</com:stateOrCountry>
  <com:zipCode>10010-3629</com:zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>59840</noOfUnitsSold>
  <aggregateMarketValue>598400</aggregateMarketValue>
  <noOfUnitsOutstanding>118097626</noOfUnitsOutstanding>
  <approxSaleDate>08/02/2023</approxSaleDate>
  <securitiesExchangeName>NYSE</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>01/11/2023</acquiredDate>
  <natureOfAcquisitionTransaction>By transfer from an affiliate of the issuer</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Costamare Shipping Services Ltd</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>59840</amountOfSecuritiesAcquired>
  <paymentDate>01/11/2023</paymentDate>
  <natureOfPayment>Cashless</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>08/01/2023</noticeDate>
  <signature>/s/ Grigorios Zikos</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2447}]
text: 144
  0001983417
  XXXXXXXX
  LIVE
  0001503584
  Costamare Inc.
  001-34934
  7 Rue du Gabian
  Monaco
  O9
  MC98000
  37793250940
  Zikos Grigorios
  CFO
  Director
  Common Stock
  Credit Suisse Securities (USA) LLC
  Eleven Madison Avenue
  New York
  NY
  10010-3629
  59840
  598400
  118097626
  08/02/2023
  NYSE
  Common Stock
  01/11/2023
  By transfer from an affiliate of the issuer
  Costamare Shipping Services Ltd
  N
  59840
  01/11/2023
  Cashless
  Y
  08/01/2023
  /s/ Grigorios Zikos