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  <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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  <issuerCik>0001808865</issuerCik>
  <issuerName>iTeos Therapeutics, Inc.</issuerName>
  <secFileNumber>001-39401</secFileNumber>
  <issuerAddress>
  <com:street1>321 Arsenal St</com:street1>
  <com:city>Watertown</com:city>
  <com:stateOrCountry>MA</com:stateOrCountry>
  <com:zipCode>02472</com:zipCode>
  </issuerAddress>
  <issuerContactPhone>339-217-0161</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Boxer Capital, LLC</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Seller's CEO is Director of Issuer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Bank of America, N.A.</name>
  <address>
  <com:street1>1111 Avenue of the Americas</com:street1>
  <com:street2>One Bryant Park</com:street2>
  <com:city>New York</com:city>
  <com:stateOrCountry>NY</com:stateOrCountry>
  <com:zipCode>10036-6706</com:zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>225000</noOfUnitsSold>
  <aggregateMarketValue>2643750</aggregateMarketValue>
  <noOfUnitsOutstanding>35781919</noOfUnitsOutstanding>
  <approxSaleDate>08/23/2023</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
  </securitiesInformation>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Piper Sandler</name>
  <address>
  <com:street1>800 Nicollet Mall</com:street1>
  <com:street2>Suite 900</com:street2>
  <com:city>Minneapolis</com:city>
  <com:stateOrCountry>MN</com:stateOrCountry>
  <com:zipCode>55402</com:zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>125000</noOfUnitsSold>
  <aggregateMarketValue>1468750</aggregateMarketValue>
  <noOfUnitsOutstanding>35781919</noOfUnitsOutstanding>
  <approxSaleDate>08/23/2023</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/24/2020</acquiredDate>
  <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>iTeos Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>350000</amountOfSecuritiesAcquired>
  <paymentDate>03/24/2020</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>Aggregate value is stated as of 8/22/2023.</remarks>
  <noticeSignature>
  <noticeDate>08/23/2023</noticeDate>
  <signature>/s/ Aaron Davis</signature>
  </noticeSignature>
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text: 144
  0001465837
  XXXXXXXX
  LIVE
  0001808865
  iTeos Therapeutics, Inc.
  001-39401
  321 Arsenal St
  Watertown
  MA
  02472
  339-217-0161
  Boxer Capital, LLC
  Seller's CEO is Director of Issuer
  Common Stock
  Bank of America, N.A.
  1111 Avenue of the Americas
  One Bryant Park
  New York
  NY
  10036-6706
  225000
  2643750
  35781919
  08/23/2023
  Nasdaq
  Common Stock
  Piper Sandler
  800 Nicollet Mall
  Suite 900
  Minneapolis
  MN
  55402
  125000
  1468750
  35781919
  08/23/2023
  Nasdaq
  Common Stock
  03/24/2020
  Private Financing
  iTeos Therapeutics, Inc.
  N
  350000
  03/24/2020
  Cash
  Y
  Aggregate value is stated as of 8/22/2023.
  08/23/2023
  /s/ Aaron Davis