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        <filer>
          <filerCredentials>
            <cik>0001737203</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
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      <issuerInfo>
        <issuerCik>0001609550</issuerCik>
        <issuerName>INSPIRE MEDICAL SYSTEMS</issuerName>
        <secFileNumber>001-38468</secFileNumber>
        <issuerAddress>
          <com:street1>5500 WAYZATA BLVD</com:street1>
          <com:street2>SUITE 1600</com:street2>
          <com:city>GOLDEN VALLEY</com:city>
          <com:stateOrCountry>MN</com:stateOrCountry>
          <com:zipCode>55416</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>844-672-4357</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jandrich Steven</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>RBC CAPITAL MARKETS LLC</name>
          <address>
            <com:street1>250 NICOLLET MALL</com:street1>
            <com:street2>SUITE 1700</com:street2>
            <com:city>MINNEAPOLIS</com:city>
            <com:stateOrCountry>MN</com:stateOrCountry>
            <com:zipCode>55401</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>8000</noOfUnitsSold>
        <aggregateMarketValue>2168128.00</aggregateMarketValue>
        <noOfUnitsOutstanding>27638570</noOfUnitsOutstanding>
        <approxSaleDate>04/25/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <acquiredDate>12/18/2018</acquiredDate>
        <natureOfAcquisitionTransaction>STOCK OPTION EXERCISE</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>8000</amountOfSecuritiesAcquired>
        <paymentDate>12/18/2018</paymentDate>
        <natureOfPayment>CHECK</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>SHARES SOLD PURSUANT TO A RULE 10B5-1 PLAN DATED 11/25/2022</remarks>
      <noticeSignature>
        <noticeDate>04/25/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>11/25/2022</planAdoptionDate>
        </planAdoptionDates>
        <signature>Jeffrey Kapala</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001737203
  XXXXXXXX
  LIVE
  0001609550
  INSPIRE MEDICAL SYSTEMS
  001-38468
  5500 WAYZATA BLVD
  SUITE 1600
  GOLDEN VALLEY
  MN
  55416
  844-672-4357
  Jandrich Steven
  Officer
  COMMON
  RBC CAPITAL MARKETS LLC
  250 NICOLLET MALL
  SUITE 1700
  MINNEAPOLIS
  MN
  55401
  8000
  2168128.00
  27638570
  04/25/2023
  NASDAQ
  COMMON
  12/18/2018
  STOCK OPTION EXERCISE
  ISSUER
  N
  8000
  12/18/2018
  CHECK
  Y
  SHARES SOLD PURSUANT TO A RULE 10B5-1 PLAN DATED 11/25/2022
  04/25/2023
  11/25/2022
  Jeffrey Kapala