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          <filerCredentials>
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            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerName>10X Genomics, Inc.</issuerName>
        <secFileNumber>001-39035</secFileNumber>
        <issuerAddress>
          <com:street1>6230 Stoneridge Mall Road</com:street1>
          <com:city>Pleasanton</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94588</com:zipCode>
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        <issuerContactPhone>925-401-7300</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Serge Saxonov</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director, CEO</relationshipToIssuer>
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        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
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          <address>
            <com:street1>390 Madison Avenue, 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
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        <noOfUnitsSold>7942</noOfUnitsSold>
        <aggregateMarketValue>83947</aggregateMarketValue>
        <noOfUnitsOutstanding>108245008</noOfUnitsOutstanding>
        <approxSaleDate>02/28/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>7942</amountOfSecuritiesAcquired>
        <paymentDate>02/21/2025</paymentDate>
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      <noticeSignature>
        <noticeDate>02/28/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>09/12/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Serge Saxonov</signature>
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text: 144
  0001786720
  XXXXXXXX
  LIVE
  0001770787
  10X Genomics, Inc.
  001-39035
  6230 Stoneridge Mall Road
  Pleasanton
  CA
  94588
  925-401-7300
  Serge Saxonov
  Director, CEO
  Class A Common Stock
  JP Morgan Securities LLC
  390 Madison Avenue, 6th Floor
  New York
  NY
  10017
  7942
  83947
  108245008
  02/28/2025
  NASDAQ
  Class A Common Stock
  02/21/2025
  RSU Vesting
  Issuer
  N
  7942
  02/21/2025
  Compensation
  Y
  02/28/2025
  09/12/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Serge Saxonov