content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001651318</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001321732</issuerCik>
        <issuerName>Penumbra Inc</issuerName>
        <secFileNumber>001-37557</secFileNumber>
        <issuerAddress>
          <com:street1>One Penumbra Place</com:street1>
          <com:city>Alameda</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94502</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>510-748-3200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Arani Bose</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>48000</noOfUnitsSold>
        <aggregateMarketValue>13701120</aggregateMarketValue>
        <noOfUnitsOutstanding>38515949</noOfUnitsOutstanding>
        <approxSaleDate>03/03/2025</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/22/2004</acquiredDate>
        <natureOfAcquisitionTransaction>Founder stock</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>48000</amountOfSecuritiesAcquired>
        <paymentDate>06/22/2004</paymentDate>
        <natureOfPayment>Founder stock</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>03/03/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>11/21/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Arani Bose</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001651318
  XXXXXXXX
  LIVE
  0001321732
  Penumbra Inc
  001-37557
  One Penumbra Place
  Alameda
  CA
  94502
  510-748-3200
  Arani Bose
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  48000
  13701120
  38515949
  03/03/2025
  NYSE
  Common
  06/22/2004
  Founder stock
  Issuer
  N
  48000
  06/22/2004
  Founder stock
  Y
  03/03/2025
  11/21/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Arani Bose