content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001442479</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001325964</issuerCik>
        <issuerName>Lightwave Logic</issuerName>
        <secFileNumber>001-40766</secFileNumber>
        <issuerAddress>
          <com:street1>369 Inverness Parkway, Suite 350</com:street1>
          <com:city>Englewood</com:city>
          <com:stateOrCountry>CO</com:stateOrCountry>
          <com:zipCode>80112</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>7203404949</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>James Marcelli</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>UBS Financial Services Inc</name>
          <address>
            <com:street1>1000 Harbor Blvd</com:street1>
            <com:street2>3rd Floor</com:street2>
            <com:city>Weehawken</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07086</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>60000</noOfUnitsSold>
        <aggregateMarketValue>276000</aggregateMarketValue>
        <noOfUnitsOutstanding>114410947</noOfUnitsOutstanding>
        <approxSaleDate>05/15/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>05/15/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Lightwave Logic</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>100000</amountOfSecuritiesAcquired>
        <paymentDate>05/15/2023</paymentDate>
        <natureOfPayment>Wire</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Shares sold to cover option cost and taxes for exercise of option expiring May 16, 2023</remarks>
      <noticeSignature>
        <noticeDate>05/12/2023</noticeDate>
        <signature>/s/ UBS Financial Services Inc, as attorney-in-fact for James Marcelli</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2925}]
text: 144
  0001442479
  XXXXXXXX
  LIVE
  0001325964
  Lightwave Logic
  001-40766
  369 Inverness Parkway, Suite 350
  Englewood
  CO
  80112
  7203404949
  James Marcelli
  Officer
  Common
  UBS Financial Services Inc
  1000 Harbor Blvd
  3rd Floor
  Weehawken
  NJ
  07086
  60000
  276000
  114410947
  05/15/2023
  Nasdaq
  Common
  05/15/2023
  Option Exercise
  Lightwave Logic
  N
  100000
  05/15/2023
  Wire
  Y
  Shares sold to cover option cost and taxes for exercise of option expiring May 16, 2023
  05/12/2023
  /s/ UBS Financial Services Inc, as attorney-in-fact for James Marcelli