content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001592238</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  
  
  
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0000834365</issuerCik>
  <issuerName>BioLife Solutions Inc.</issuerName>
  <secFileNumber>001-36362</secFileNumber>
  <issuerAddress>
  <com:street1>3303 Monte Villa Parkway</com:street1>
  <com:street2>Suite 310</com:street2>
  <com:city>Bothell</com:city>
  <com:stateOrCountry>WA</com:stateOrCountry>
  <com:zipCode>98021</com:zipCode>
  </issuerAddress>
  <issuerContactPhone>425-402-1400</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Schick Joseph</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Former Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Siebert &amp; Co., Inc.</name>
  <address>
  <com:street1>18045 Oak Street</com:street1>
  <com:city>Omaha</com:city>
  <com:stateOrCountry>NE</com:stateOrCountry>
  <com:zipCode>68130</com:zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>6719</noOfUnitsSold>
  <aggregateMarketValue>171327.78</aggregateMarketValue>
  <noOfUnitsOutstanding>46138201</noOfUnitsOutstanding>
  <approxSaleDate>08/14/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>08/01/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Vesting of restricted stock awards.</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>BioLife Solutions Inc.</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>6719</amountOfSecuritiesAcquired>
  <paymentDate>08/01/2022</paymentDate>
  <natureOfPayment>Equity compensation for services rendered.</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>Shares to be sold were acquired between 1/1/2022 and 8/1/2022 upon the vesting of restricted stock awards.</remarks>
  <noticeSignature>
  <noticeDate>08/19/2024</noticeDate>
  <signature>/s/ Joseph Schick</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2576}]
text: 144
  0001592238
  XXXXXXXX
  LIVE
  0000834365
  BioLife Solutions Inc.
  001-36362
  3303 Monte Villa Parkway
  Suite 310
  Bothell
  WA
  98021
  425-402-1400
  Schick Joseph
  Former Director
  Common Stock
  Siebert & Co., Inc.
  18045 Oak Street
  Omaha
  NE
  68130
  6719
  171327.78
  46138201
  08/14/2024
  NASDAQ
  Common Stock
  08/01/2022
  Vesting of restricted stock awards.
  BioLife Solutions Inc.
  N
  6719
  08/01/2022
  Equity compensation for services rendered.
  Y
  Shares to be sold were acquired between 1/1/2022 and 8/1/2022 upon the vesting of restricted stock awards.
  08/19/2024
  /s/ Joseph Schick