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  <issuerAddress>
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  <com:street2>Suite 901</com:street2>
  <com:city>Boston</com:city>
  <com:stateOrCountry>MA</com:stateOrCountry>
  <com:zipCode>02215</com:zipCode>
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  <issuerContactPhone>857-320-4900</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MVA Investors, LLC</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
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  <address>
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  <com:street2>One Bryant Park</com:street2>
  <com:city>New York</com:city>
  <com:stateOrCountry>NY</com:stateOrCountry>
  <com:zipCode>10036-6706</com:zipCode>
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  <aggregateMarketValue>546000</aggregateMarketValue>
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  <approxSaleDate>05/02/2024</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>10/11/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Open Market Purchases</natureOfAcquisitionTransaction>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>10/12/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Open Market Purchases</natureOfAcquisitionTransaction>
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  <natureOfPayment>Cash</natureOfPayment>
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  <address>
  <com:street1>12860 El Camino Real, Suite 300</com:street1>
  <com:city>San Diego</com:city>
  <com:stateOrCountry>CA</com:stateOrCountry>
  <com:zipCode>92130</com:zipCode>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
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  <amountOfSecuritiesSold>75000</amountOfSecuritiesSold>
  <grossProceeds>577500</grossProceeds>
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  <remarks>Aggregate Market Value as of 05/01/2024</remarks>
  <noticeSignature>
  <noticeDate>05/02/2024</noticeDate>
  <signature>/s/ Aaron Davis, Chief Executive Officer</signature>
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text: 144
  0001468223
  XXXXXXXX
  LIVE
  0001819133
  Tango Therapeutics, Inc.
  001-39485
  201 Brookline Ave
  Suite 901
  Boston
  MA
  02215
  857-320-4900
  MVA Investors, LLC
  member of group owning over 10% of the shares
  Common Stock
  BofA Securities Inc.
  1111 Ave of the Americas
  One Bryant Park
  New York
  NY
  10036-6706
  75000
  546000
  106718315
  05/02/2024
  Nasdaq
  Common Stock
  10/11/2022
  Open Market Purchases
  Tango Therapeutics, Inc.
  N
  48476
  10/11/2022
  Cash
  Common Stock
  10/12/2022
  Open Market Purchases
  Tango Therapeutics, Inc.
  N
  26524
  10/12/2022
  Cash
  N
  MVA Investors, LLC
  12860 El Camino Real, Suite 300
  San Diego
  CA
  92130
  Common Stock
  05/01/2024
  75000
  577500
  Aggregate Market Value as of 05/01/2024
  05/02/2024
  /s/ Aaron Davis, Chief Executive Officer