content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001862900</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001861560</issuerCik>
        <issuerName>Nuvalent, Inc.</issuerName>
        <secFileNumber>001-40671</secFileNumber>
        <issuerAddress>
          <com:street1>One Broadway, 14th floor</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>8573577000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>James Richard Porter</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>81000</noOfUnitsSold>
        <aggregateMarketValue>6851790</aggregateMarketValue>
        <noOfUnitsOutstanding>66373511</noOfUnitsOutstanding>
        <approxSaleDate>07/15/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <acquiredDate>07/15/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>81000</amountOfSecuritiesAcquired>
        <paymentDate>07/15/2025</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>James Richard Porter</name>
          <address>
            <com:street1>C/o Issuer</com:street1>
            <com:street2>One Broadway, 14th floor</com:street2>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>05/15/2025</saleDate>
        <amountOfSecuritiesSold>27000</amountOfSecuritiesSold>
        <grossProceeds>1879251</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>James Richard Porter</name>
          <address>
            <com:street1>C/o Issuer</com:street1>
            <com:street2>One Broadway, 14th floor</com:street2>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>06/16/2025</saleDate>
        <amountOfSecuritiesSold>27000</amountOfSecuritiesSold>
        <grossProceeds>2077096</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>The sales under this filing are from Cashless Option Exercises that will occur within 3 months from the date of this filing.</remarks>
      <noticeSignature>
        <noticeDate>07/15/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>04/02/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for James Richard Porter.</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4431}]
text: 144
  0001862900
  XXXXXXXX
  LIVE
  0001861560
  Nuvalent, Inc.
  001-40671
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  8573577000
  James Richard Porter
  Officer
  Class A Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  81000
  6851790
  66373511
  07/15/2025
  NASDAQ
  Class A Common
  07/15/2025
  Stock Option Exercise
  Issuer
  N
  81000
  07/15/2025
  Cash
  N
  James Richard Porter
  C/o Issuer
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  05/15/2025
  27000
  1879251
  James Richard Porter
  C/o Issuer
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  06/16/2025
  27000
  2077096
  The sales under this filing are from Cashless Option Exercises that will occur within 3 months from the date of this filing.
  07/15/2025
  04/02/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for James Richard Porter.