content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <!-- Field: Pseudo-Tag; ID: Name; Data: OrbiMed Advisors Israel II Ltd -->
            <cik>0001682093</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001800315</issuerCik>
        <issuerName>Galecto, Inc.</issuerName>
        <secFileNumber>001-39655</secFileNumber>
        <issuerAddress>
          <com:street1>75 State Street</com:street1>
          <com:street2>Suite 100</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02109</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>45-70-70-52-10</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>OrbiMed Israel Partners II, L.P.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Shareholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Themis Trading LLC</name>
          <address>
            <com:street1>10 Town Square</com:street1>
            <com:street2>Suite 100</com:street2>
            <com:city>Chatham</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07928</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>43810</noOfUnitsSold>
        <aggregateMarketValue>97915.35</aggregateMarketValue>
        <noOfUnitsOutstanding>25673474</noOfUnitsOutstanding>
        <approxSaleDate>04/05/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq Stock Market</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>09/25/2020</acquiredDate>
        <natureOfAcquisitionTransaction>Private placement</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>43810</amountOfSecuritiesAcquired>
        <paymentDate>09/25/2020</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>OrbiMed Israel GP II, L.P. is the general partner of OrbiMed Israel Partners II, L.P. OrbiMed Advisors Israel II Limited is the general partner of OrbiMed Israel GP II, L.P.</remarks>
      <noticeSignature>
        <noticeDate>04/05/2023</noticeDate>
        <signature>/s/ Douglas Coon, Compliance Officer, OrbiMed Advisors Israel II Limited, general partner of the general partner of OrbiMed Israel Partners II, L.P.</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001682093
  XXXXXXXX
  LIVE
  0001800315
  Galecto, Inc.
  001-39655
  75 State Street
  Suite 100
  Boston
  MA
  02109
  45-70-70-52-10
  OrbiMed Israel Partners II, L.P.
  Shareholder
  Common Stock
  Themis Trading LLC
  10 Town Square
  Suite 100
  Chatham
  NJ
  07928
  43810
  97915.35
  25673474
  04/05/2023
  Nasdaq Stock Market
  Common Stock
  09/25/2020
  Private placement
  Issuer
  N
  43810
  09/25/2020
  Cash
  Y
  OrbiMed Israel GP II, L.P. is the general partner of OrbiMed Israel Partners II, L.P. OrbiMed Advisors Israel II Limited is the general partner of OrbiMed Israel GP II, L.P.
  04/05/2023
  /s/ Douglas Coon, Compliance Officer, OrbiMed Advisors Israel II Limited, general partner of the general partner of OrbiMed Israel Partners II, L.P.