content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
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  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001400973</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001652130</issuerCik>
  <issuerName>Intellia Therapeutics, Inc.</issuerName>
  <secFileNumber>001-37766</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">40 Erie Street</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 130</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Cambridge</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02139</zipCode>
  </issuerAddress>
  <issuerContactPhone>857-285-6200</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>John F. Crowley</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Former Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>E*Trade Financial Corporation</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 Edison Drive</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Alpharetta </city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30035</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>32791</noOfUnitsSold>
  <aggregateMarketValue>506703.83</aggregateMarketValue>
  <noOfUnitsOutstanding>89554891</noOfUnitsOutstanding>
  <approxSaleDate>12/06/2023</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>12/06/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>25500</amountOfSecuritiesAcquired>
  <paymentDate>12/06/2023</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>06/14/2022</acquiredDate>
  <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2094</amountOfSecuritiesAcquired>
  <paymentDate>06/14/2022</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>06/14/2023</acquiredDate>
  <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>5197</amountOfSecuritiesAcquired>
  <paymentDate>06/14/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>12/07/2023</noticeDate>
  <signature>/s/ John F. Crowley</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3661}]
text: 144
  0001400973
  XXXXXXXX
  LIVE
  0001652130
  Intellia Therapeutics, Inc.
  001-37766
  40 Erie Street
  Suite 130
  Cambridge
  MA
  02139
  857-285-6200
  John F. Crowley
  Former Director
  Common Stock
  E*Trade Financial Corporation
  3 Edison Drive
  Alpharetta
  GA
  30035
  32791
  506703.83
  89554891
  12/06/2023
  NASDAQ
  Common Stock
  12/06/2023
  Option Exercise
  Issuer
  N
  25500
  12/06/2023
  Cash
  Common Stock
  06/14/2022
  RSU Vesting
  Issuer
  N
  2094
  06/14/2022
  N/A
  Common Stock
  06/14/2023
  RSU Vesting
  Issuer
  N
  5197
  06/14/2023
  N/A
  Y
  12/07/2023
  /s/ John F. Crowley