content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001954991</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001707502</issuerCik>
  <issuerName>Solid Biosciences Inc.</issuerName>
  <secFileNumber>001-38360</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">500 Rutherford Avenue</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Charlestown</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02129</zipCode>
  </issuerAddress>
  <issuerContactPhone>(617)-337-4680</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Herzich Paul</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>ETRADE FINANCIAL CORPORATION</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 EDISON DRIVE</street1>
  <city xmlns="http://www.sec.gov/edgar/common">ALPHARETTA</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>2688</noOfUnitsSold>
  <aggregateMarketValue>10644.48</aggregateMarketValue>
  <noOfUnitsOutstanding>40579183</noOfUnitsOutstanding>
  <approxSaleDate>02/14/2025</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>02/13/2025</acquiredDate>
  <natureOfAcquisitionTransaction>Settlement of vested restricted stock units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2688</amountOfSecuritiesAcquired>
  <paymentDate>02/13/2025</paymentDate>
  <natureOfPayment>Compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Paul Herzich</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">500 Rutherford Avenue</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 3</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Charlestown</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02129</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>12/03/2024</saleDate>
  <amountOfSecuritiesSold>2777</amountOfSecuritiesSold>
  <grossProceeds>15550.73</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>The sales reported on this Form 144 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units. These sales do not represent discretionary trades by the Reporting Person.</remarks>
  <noticeSignature>
  <noticeDate>02/14/2025</noticeDate>
  <signature>/s/ Kimberly Cornwell as attorney-in-fact for Paul Herzich</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3705}]
text: 144
  0001954991
  XXXXXXXX
  LIVE
  0001707502
  Solid Biosciences Inc.
  001-38360
  500 Rutherford Avenue
  Charlestown
  MA
  02129
  (617)-337-4680
  Herzich Paul
  Officer
  Common Stock
  ETRADE FINANCIAL CORPORATION
  3 EDISON DRIVE
  ALPHARETTA
  GA
  30005
  2688
  10644.48
  40579183
  02/14/2025
  NASDAQ
  Common Stock
  02/13/2025
  Settlement of vested restricted stock units
  Issuer
  N
  2688
  02/13/2025
  Compensation
  N
  Paul Herzich
  500 Rutherford Avenue
  Suite 3
  Charlestown
  MA
  02129
  Common Stock
  12/03/2024
  2777
  15550.73
  The sales reported on this Form 144 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units. These sales do not represent discretionary trades by the Reporting Person.
  02/14/2025
  /s/ Kimberly Cornwell as attorney-in-fact for Paul Herzich