content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001697720</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001192448</issuerCik>
  <issuerName>GLAUKOS Corp.</issuerName>
  <secFileNumber>001-37463</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">229 AVENIDA FABRICANTE</street1>
  <city xmlns="http://www.sec.gov/edgar/common">SAN CLEMENTE</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">92672</zipCode>
  </issuerAddress>
  <issuerContactPhone>949-367-9600</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>InterWest Venture Management Co</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Entity controlled by GKOS Director, Gilbert Kliman</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Merrill Lynch</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">555 California Street</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 1800</street2>
  <city xmlns="http://www.sec.gov/edgar/common">San Francisco</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">94104</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>16347</noOfUnitsSold>
  <aggregateMarketValue>1503924</aggregateMarketValue>
  <noOfUnitsOutstanding>49470423</noOfUnitsOutstanding>
  <approxSaleDate>02/27/2024</approxSaleDate>
  <securitiesExchangeName>NYSE</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>06/07/2019</acquiredDate>
  <natureOfAcquisitionTransaction>Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from the Issuer for board service.</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Gilbert Kliman</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>4633</amountOfSecuritiesAcquired>
  <paymentDate>05/31/2019</paymentDate>
  <natureOfPayment>Service-based RSU granted by Issuer 5/31/2018</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/10/2019</acquiredDate>
  <natureOfAcquisitionTransaction>Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from the Issuer for board service.</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Gilbert Kliman</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>3356</amountOfSecuritiesAcquired>
  <paymentDate>08/06/2019</paymentDate>
  <natureOfPayment>Service-based RSU granted by Issuer 1/2/2019-5/30/2019</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/12/2019</acquiredDate>
  <natureOfAcquisitionTransaction>Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from Avedro for board service.</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Gilbert Kliman</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>1096</amountOfSecuritiesAcquired>
  <paymentDate>08/06/2019</paymentDate>
  <natureOfPayment>Service-based RSU granted by Avedro 6/4/2019 and exchanged for Issuer shares at closing of merger 11/21/2019</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/08/2021</acquiredDate>
  <natureOfAcquisitionTransaction>Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from the Issuer for board service.</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Gilbert Kliman</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>3900</amountOfSecuritiesAcquired>
  <paymentDate>06/04/2021</paymentDate>
  <natureOfPayment>Service-based RSU granted by Issuer 6/3/2020</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>05/18/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from the Issuer for board service.</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Gilbert Kliman</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>980</amountOfSecuritiesAcquired>
  <paymentDate>01/03/2022</paymentDate>
  <natureOfPayment>Service-based RSU granted by Issuer 1/3/2021</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>08/19/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from the Issuer for board service.</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Gilbert Kliman</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2382</amountOfSecuritiesAcquired>
  <paymentDate>06/03/2022</paymentDate>
  <natureOfPayment>Serivce-based RSU granted by Issuer 6/3/2021</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>02/27/2024</noticeDate>
  <signature>Karen Wilson, CFO</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6335}]
text: 144
  0001697720
  XXXXXXXX
  LIVE
  0001192448
  GLAUKOS Corp.
  001-37463
  229 AVENIDA FABRICANTE
  SAN CLEMENTE
  CA
  92672
  949-367-9600
  InterWest Venture Management Co
  Entity controlled by GKOS Director, Gilbert Kliman
  Common Stock
  Merrill Lynch
  555 California Street
  Suite 1800
  San Francisco
  CA
  94104
  16347
  1503924
  49470423
  02/27/2024
  NYSE
  Common Stock
  06/07/2019
  Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from the Issuer for board service.
  Gilbert Kliman
  N
  4633
  05/31/2019
  Service-based RSU granted by Issuer 5/31/2018
  Common Stock
  09/10/2019
  Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from the Issuer for board service.
  Gilbert Kliman
  N
  3356
  08/06/2019
  Service-based RSU granted by Issuer 1/2/2019-5/30/2019
  Common Stock
  09/12/2019
  Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from Avedro for board service.
  Gilbert Kliman
  N
  1096
  08/06/2019
  Service-based RSU granted by Avedro 6/4/2019 and exchanged for Issuer shares at closing of merger 11/21/2019
  Common Stock
  09/08/2021
  Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from the Issuer for board service.
  Gilbert Kliman
  N
  3900
  06/04/2021
  Service-based RSU granted by Issuer 6/3/2020
  Common Stock
  05/18/2022
  Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from the Issuer for board service.
  Gilbert Kliman
  N
  980
  01/03/2022
  Service-based RSU granted by Issuer 1/3/2021
  Common Stock
  08/19/2022
  Received for no consideration from Gilbert Kliman pursuant to an agreement with respect to compensation Mr. Kliman received from the Issuer for board service.
  Gilbert Kliman
  N
  2382
  06/03/2022
  Serivce-based RSU granted by Issuer 6/3/2021
  Y
  02/27/2024
  Karen Wilson, CFO