content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001619961</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001582313</issuerCik>
  <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
  <secFileNumber>001-36687</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">3650 Gilmore Way</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Burnaby</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A1</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V5G 4W8</zipCode>
  </issuerAddress>
  <issuerContactPhone>(604)-484-3300</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>IAN MORTIMER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Canaccord Genuity Corp.</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1133 Melville St</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 1200</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Vancouver, BC</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">Z4</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V6E 4E5</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>16217</noOfUnitsSold>
  <aggregateMarketValue>649927.65</aggregateMarketValue>
  <noOfUnitsOutstanding>76239602</noOfUnitsOutstanding>
  <approxSaleDate>01/23/2025</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <acquiredDate>01/23/2025</acquiredDate>
  <natureOfAcquisitionTransaction>Exercise of Options</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>16217</amountOfSecuritiesAcquired>
  <paymentDate>01/23/2025</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>The Common Shares reported on this Form 144 were obtained via the exercise of options scheduled to expire on March 16, 2025, and are being sold pursuant to a Rule 10b5-1 trading plan.</remarks>
  <noticeSignature>
  <noticeDate>01/23/2025</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>09/27/2024</planAdoptionDate>
  </planAdoptionDates>
  <signature>/s/ Ian Mortimer</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3071}]
text: 144
  0001619961
  XXXXXXXX
  LIVE
  0001582313
  Xenon Pharmaceuticals Inc.
  001-36687
  3650 Gilmore Way
  Burnaby
  A1
  V5G 4W8
  (604)-484-3300
  IAN MORTIMER
  Officer
  Director
  Common Shares
  Canaccord Genuity Corp.
  1133 Melville St
  Suite 1200
  Vancouver, BC
  Z4
  V6E 4E5
  16217
  649927.65
  76239602
  01/23/2025
  NASDAQ
  Common Shares
  01/23/2025
  Exercise of Options
  Issuer
  N
  16217
  01/23/2025
  Cash
  Y
  The Common Shares reported on this Form 144 were obtained via the exercise of options scheduled to expire on March 16, 2025, and are being sold pursuant to a Rule 10b5-1 trading plan.
  01/23/2025
  09/27/2024
  /s/ Ian Mortimer