content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001847941</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001818794</issuerCik>
  <issuerName>Dyne Therapeutics, Inc.</issuerName>
  <secFileNumber>001-39509</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </issuerAddress>
  <issuerContactPhone>(781)-786-8230</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Wildon Farwell</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Stifel Financial Corporation</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 Bryant Park, 4th Floor</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">1095 Avenue of the Americas</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10036</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>5493</noOfUnitsSold>
  <aggregateMarketValue>137713</aggregateMarketValue>
  <noOfUnitsOutstanding>61375598</noOfUnitsOutstanding>
  <approxSaleDate>02/12/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/01/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Shares acquired upon vesting of restricted stock units granted pursuant to issuer's 2020 stock incentive plan</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>5493</amountOfSecuritiesAcquired>
  <paymentDate>03/01/2022</paymentDate>
  <natureOfPayment>Equity compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Wildon Farwell</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>12/11/2023</saleDate>
  <amountOfSecuritiesSold>1688</amountOfSecuritiesSold>
  <grossProceeds>18095</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Wildon Farwell</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>12/12/2023</saleDate>
  <amountOfSecuritiesSold>978</amountOfSecuritiesSold>
  <grossProceeds>10318</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Wildon Farwell</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>01/26/2024</saleDate>
  <amountOfSecuritiesSold>100</amountOfSecuritiesSold>
  <grossProceeds>2500</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>The sales reported in this Form 144 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 14, 2023. Securities sold on December 11, 2023 represent shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on December 10, 2021 and December 9, 2022. The sales reported on December 12, 2023 and January 26, 2024 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 14, 2023.</remarks>
  <noticeSignature>
  <noticeDate>02/12/2024</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>07/14/2023</planAdoptionDate>
  </planAdoptionDates>
  <signature>/s/ Richard Scalzo, Attorney-in-Fact</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5349}]
text: 144
  0001847941
  XXXXXXXX
  LIVE
  0001818794
  Dyne Therapeutics, Inc.
  001-39509
  1560 Trapelo Road
  Waltham
  MA
  02451
  (781)-786-8230
  Wildon Farwell
  Officer
  Common Stock
  Stifel Financial Corporation
  3 Bryant Park, 4th Floor
  1095 Avenue of the Americas
  New York
  NY
  10036
  5493
  137713
  61375598
  02/12/2024
  NASDAQ
  Common Stock
  03/01/2022
  Shares acquired upon vesting of restricted stock units granted pursuant to issuer's 2020 stock incentive plan
  Issuer
  N
  5493
  03/01/2022
  Equity compensation
  N
  Wildon Farwell
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  12/11/2023
  1688
  18095
  Wildon Farwell
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  12/12/2023
  978
  10318
  Wildon Farwell
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  01/26/2024
  100
  2500
  The sales reported in this Form 144 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 14, 2023. Securities sold on December 11, 2023 represent shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on December 10, 2021 and December 9, 2022. The sales reported on December 12, 2023 and January 26, 2024 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 14, 2023.
  02/12/2024
  07/14/2023
  /s/ Richard Scalzo, Attorney-in-Fact