content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001824673</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001818794</issuerCik>
  <issuerName>Dyne Therapeutics, Inc.</issuerName>
  <secFileNumber>001-39509</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </issuerAddress>
  <issuerContactPhone>(781)-786-8230</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jonathan McNeill</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Stifel Financial Corporation</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 Bryant Park, 4th Floor</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">1095 Avenue of the Americas</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10036</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>11900</noOfUnitsSold>
  <aggregateMarketValue>158270</aggregateMarketValue>
  <noOfUnitsOutstanding>61375598</noOfUnitsOutstanding>
  <approxSaleDate>01/02/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>12/10/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>110</amountOfSecuritiesAcquired>
  <paymentDate>12/10/2022</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/10/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>1606</amountOfSecuritiesAcquired>
  <paymentDate>03/10/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>06/10/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>1729</amountOfSecuritiesAcquired>
  <paymentDate>06/10/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/10/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2816</amountOfSecuritiesAcquired>
  <paymentDate>09/10/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/17/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2950</amountOfSecuritiesAcquired>
  <paymentDate>09/17/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>12/10/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2689</amountOfSecuritiesAcquired>
  <paymentDate>12/10/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Jonathan McNeill</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>12/11/2023</saleDate>
  <amountOfSecuritiesSold>1245</amountOfSecuritiesSold>
  <grossProceeds>13346</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>The proposed sales reported in this Form 144 are to be effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023. Securities sold on December 11, 2023 represent shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on December 10, 2021 and December 9, 2022.</remarks>
  <noticeSignature>
  <noticeDate>12/29/2023</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>06/29/2023</planAdoptionDate>
  </planAdoptionDates>
  <signature>/s/ Richard Scalzo, Attorney-in-Fact</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6810}]
text: 144
  0001824673
  XXXXXXXX
  LIVE
  0001818794
  Dyne Therapeutics, Inc.
  001-39509
  1560 Trapelo Road
  Waltham
  MA
  02451
  (781)-786-8230
  Jonathan McNeill
  Officer
  Common Stock
  Stifel Financial Corporation
  3 Bryant Park, 4th Floor
  1095 Avenue of the Americas
  New York
  NY
  10036
  11900
  158270
  61375598
  01/02/2024
  NASDAQ
  Common Stock
  12/10/2022
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  110
  12/10/2022
  N/A
  Common Stock
  03/10/2023
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  1606
  03/10/2023
  N/A
  Common Stock
  06/10/2023
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  1729
  06/10/2023
  N/A
  Common Stock
  09/10/2023
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  2816
  09/10/2023
  N/A
  Common Stock
  09/17/2023
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  2950
  09/17/2023
  N/A
  Common Stock
  12/10/2023
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  2689
  12/10/2023
  N/A
  N
  Jonathan McNeill
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  12/11/2023
  1245
  13346
  The proposed sales reported in this Form 144 are to be effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023. Securities sold on December 11, 2023 represent shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on December 10, 2021 and December 9, 2022.
  12/29/2023
  06/29/2023
  /s/ Richard Scalzo, Attorney-in-Fact