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  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
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  <issuerContactPhone>781-786-8230</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Joshua Brumm</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
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  <relationshipToIssuer>CEO and President</relationshipToIssuer>
  </relationshipsToIssuer>
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  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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  <acquiredDate>09/17/2021</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
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  <amountOfSecuritiesAcquired>3248</amountOfSecuritiesAcquired>
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  <acquiredDate>09/10/2022</acquiredDate>
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  <amountOfSecuritiesAcquired>3907</amountOfSecuritiesAcquired>
  <paymentDate>09/10/2022</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/17/2022</acquiredDate>
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  <paymentDate>09/17/2022</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
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  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>12/10/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
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  <paymentDate>12/10/2022</paymentDate>
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  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/10/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
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  <amountOfSecuritiesAcquired>9069</amountOfSecuritiesAcquired>
  <paymentDate>03/10/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
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  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>06/08/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Stock option exercise</natureOfAcquisitionTransaction>
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  <amountOfSecuritiesAcquired>26588</amountOfSecuritiesAcquired>
  <paymentDate>06/08/2023</paymentDate>
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  <saleDate>03/14/2023</saleDate>
  <amountOfSecuritiesSold>7318</amountOfSecuritiesSold>
  <grossProceeds>97549.00</grossProceeds>
  </securitiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>06/08/2023</noticeDate>
  <signature>/s/ Richard Scalzo, Attorney-in-Fact</signature>
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metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6202}]
text: 144
  0001528826
  XXXXXXXX
  LIVE
  0001818794
  Dyne Therapeutics, Inc.
  001-39509
  1560 Trapelo Road
  Waltham
  MA
  02451
  781-786-8230
  Joshua Brumm
  CEO and President
  Common Stock
  Stifel Financial Corporation
  3 Bryant Park, 4th Floor
  1095 Avenue of the Americas
  New York
  NY
  10036
  61000
  806614.00
  58310703
  06/08/2023
  NASDAQ
  Common Stock
  09/17/2021
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  3248
  09/17/2021
  N/A
  Common Stock
  09/10/2022
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  3907
  09/10/2022
  N/A
  Common Stock
  09/17/2022
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  14920
  09/17/2022
  N/A
  Common Stock
  12/10/2022
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  3268
  12/10/2022
  N/A
  Common Stock
  03/10/2023
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  9069
  03/10/2023
  N/A
  Common Stock
  06/08/2023
  Stock option exercise
  Issuer
  N
  26588
  06/08/2023
  Cash
  N
  Joshua Brumm
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  03/14/2023
  7318
  97549.00
  06/08/2023
  /s/ Richard Scalzo, Attorney-in-Fact