content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001999313</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001682241</issuerCik>
        <issuerName>Metalpha Technology Holding Limited</issuerName>
        <secFileNumber>001-38208</secFileNumber>
        <issuerAddress>
          <com:street1>Suite 6703-04, Central Plaza 18 Harbour</com:street1>
          <com:street2>Road, Wan Chai, Hong Kong, China</com:street2>
          <com:city>Hong Kong</com:city>
          <com:stateOrCountry>K3</com:stateOrCountry>
          <com:zipCode>0000</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>852 35652920</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>LSQ Investment Fund SPC - Disruptive Opportunity Fund II SP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Ordinary Shares</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name> Tiger Brokers (Singapore ) Pte. Ltd.</name>
          <address>
            <com:street1> 1 Raffles Place, #35-61, One Raffles</com:street1>
            <com:street2>Place Tower 2 </com:street2>
            <com:city>Singapore</com:city>
            <com:stateOrCountry>U0</com:stateOrCountry>
            <com:zipCode>048616</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>383733</noOfUnitsSold>
        <aggregateMarketValue>429780.96</aggregateMarketValue>
        <noOfUnitsOutstanding>38373371</noOfUnitsOutstanding>
        <approxSaleDate>11/15/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Ordinary Shares</securitiesClassTitle>
        <acquiredDate>10/28/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Through a private placement from the issuer of the securities</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Metalpha Technology Holding Limited</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>383733</amountOfSecuritiesAcquired>
        <paymentDate>10/28/2021</paymentDate>
        <natureOfPayment>Bank Wire Transfer</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>11/15/2024</noticeDate>
        <signature>Nan Zhao as a duly authorized representative of Tiger Brokers (Singapore ) Pte. Ltd. as attorney-in-fact for client LSQ Investment Fund SPC-Disruptive</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001999313
  XXXXXXXX
  LIVE
  0001682241
  Metalpha Technology Holding Limited
  001-38208
  Suite 6703-04, Central Plaza 18 Harbour
  Road, Wan Chai, Hong Kong, China
  Hong Kong
  K3
  0000
  852 35652920
  LSQ Investment Fund SPC - Disruptive Opportunity Fund II SP
  10% Stockholder
  Ordinary Shares
  Tiger Brokers (Singapore ) Pte. Ltd.
  1 Raffles Place, #35-61, One Raffles
  Place Tower 2
  Singapore
  U0
  048616
  383733
  429780.96
  38373371
  11/15/2024
  NASDAQ
  Ordinary Shares
  10/28/2021
  Through a private placement from the issuer of the securities
  Metalpha Technology Holding Limited
  N
  383733
  10/28/2021
  Bank Wire Transfer
  Y
  11/15/2024
  Nan Zhao as a duly authorized representative of Tiger Brokers (Singapore ) Pte. Ltd. as attorney-in-fact for client LSQ Investment Fund SPC-Disruptive