content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001751980</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001321732</issuerCik>
        <issuerName>Penumbra, Inc.</issuerName>
        <secFileNumber>001-37557</secFileNumber>
        <issuerAddress>
          <com:street1>One Penumbra Place</com:street1>
          <com:city>Alameda</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94502</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>510-748-3200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Johanna Roberts</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3600</noOfUnitsSold>
        <aggregateMarketValue>1027949</aggregateMarketValue>
        <noOfUnitsOutstanding>38515949</noOfUnitsOutstanding>
        <approxSaleDate>03/03/2025</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/03/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1855</amountOfSecuritiesAcquired>
        <paymentDate>03/03/2025</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>12/15/2023</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1745</amountOfSecuritiesAcquired>
        <paymentDate>12/15/2023</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The shares represented by this filing are RSU Vestings acquired during 12/15/23 - 04/15/24 and option exercises.  These shares are expected to be sold within 3 months of this filing.</remarks>
      <noticeSignature>
        <noticeDate>03/03/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>11/26/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Johanna Roberts</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3687}]
text: 144
  0001751980
  XXXXXXXX
  LIVE
  0001321732
  Penumbra, Inc.
  001-37557
  One Penumbra Place
  Alameda
  CA
  94502
  510-748-3200
  Johanna Roberts
  Officer
  Common Stock
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  3600
  1027949
  38515949
  03/03/2025
  NYSE
  Common Stock
  03/03/2025
  Option Exercise
  Issuer
  N
  1855
  03/03/2025
  Cash
  Common Stock
  12/15/2023
  RSU Vesting
  Issuer
  N
  1745
  12/15/2023
  Compensation
  Y
  The shares represented by this filing are RSU Vestings acquired during 12/15/23 - 04/15/24 and option exercises.  These shares are expected to be sold within 3 months of this filing.
  03/03/2025
  11/26/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Johanna Roberts