content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001886575</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001658247</issuerCik>
        <issuerName>Crinetics Pharmaceuticals, Inc.</issuerName>
        <secFileNumber>001-38583</secFileNumber>
        <issuerAddress>
          <com:street1>10222 BARNES CANYON ROAD, BLDG. #2</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92121</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>858-450-6464</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Betz Stephen F.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Co-Founder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Ameriprise Financial</name>
          <address>
            <com:street1>2865 Ameriprise Financial Center</com:street1>
            <com:city>Minneapolis</com:city>
            <com:stateOrCountry>MN</com:stateOrCountry>
            <com:zipCode>55474</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3000</noOfUnitsSold>
        <aggregateMarketValue>107679.60</aggregateMarketValue>
        <noOfUnitsOutstanding>66799257</noOfUnitsOutstanding>
        <approxSaleDate>12/26/2023</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/16/2015</acquiredDate>
        <natureOfAcquisitionTransaction>Purchased on open market</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>N/A</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3000</amountOfSecuritiesAcquired>
        <paymentDate>03/16/2015</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Stephen Betz</name>
          <address>
            <com:street1>1220 Highland Drive</com:street1>
            <com:city>Del Mar</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>92014</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>11/27/2023</saleDate>
        <amountOfSecuritiesSold>3000</amountOfSecuritiesSold>
        <grossProceeds>95206.20</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Stephen Betz</name>
          <address>
            <com:street1>1220 Highland Drive</com:street1>
            <com:city>Del Mar</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>92014</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>12/11/2023</saleDate>
        <amountOfSecuritiesSold>3000</amountOfSecuritiesSold>
        <grossProceeds>98598.90</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Sale made as part of a 10B5-1 plan</remarks>
      <noticeSignature>
        <noticeDate>12/26/2023</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>08/25/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ Alexander Meginnes as a duly authorized representative of Ameriprise Financial Services Inc, as attorney-in-fact for Stephen Betz</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001886575
  XXXXXXXX
  LIVE
  0001658247
  Crinetics Pharmaceuticals, Inc.
  001-38583
  10222 BARNES CANYON ROAD, BLDG. #2
  SAN DIEGO
  CA
  92121
  858-450-6464
  Betz Stephen F.
  Officer
  Co-Founder
  Common
  Ameriprise Financial
  2865 Ameriprise Financial Center
  Minneapolis
  MN
  55474
  3000
  107679.60
  66799257
  12/26/2023
  NASDAQ
  Common
  03/16/2015
  Purchased on open market
  N/A
  N
  3000
  03/16/2015
  Cash
  N
  Stephen Betz
  1220 Highland Drive
  Del Mar
  CA
  92014
  Common
  11/27/2023
  3000
  95206.20
  Stephen Betz
  1220 Highland Drive
  Del Mar
  CA
  92014
  Common
  12/11/2023
  3000
  98598.90
  Sale made as part of a 10B5-1 plan
  12/26/2023
  08/25/2023
  /s/ Alexander Meginnes as a duly authorized representative of Ameriprise Financial Services Inc, as attorney-in-fact for Stephen Betz