content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001989488</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001971543</issuerCik>
  <issuerName>Mural Oncology plc</issuerName>
  <secFileNumber>001-41837</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">10 Earlsfort Terrace</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Dublin 2</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">L2</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">D02 T380</zipCode>
  </issuerAddress>
  <issuerContactPhone>353-1-905-8020</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Loew Caroline</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Ordinary Shares</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>MorganStanley Private Bank</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">Harborside 2</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">200 Hudson Street, Suite 501</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Jersey City</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NJ</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">07311</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>12513</noOfUnitsSold>
  <aggregateMarketValue>30469</aggregateMarketValue>
  <noOfUnitsOutstanding>17268881</noOfUnitsOutstanding>
  <approxSaleDate>07/07/2025</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Ordinary Shares</securitiesClassTitle>
  <acquiredDate>07/05/2025</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>12513</amountOfSecuritiesAcquired>
  <paymentDate>07/05/2025</paymentDate>
  <natureOfPayment>Equity Compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>Represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on Dcember 14, 2023. The automatic sale of the Reporting Person's shares is provided for in a restricted stock unit agreement that includes a "binding contract" consistent with the affirmative defense to liability uner Rule 10b5-1 that was entered on March 27, 2024, and the sale does not represent a discretionary trade by the Reporting Person.</remarks>
  <noticeSignature>
  <noticeDate>07/09/2025</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>03/27/2024</planAdoptionDate>
  </planAdoptionDates>
  <signature>/s/ Caroline Loew</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3453}]
text: 144
  0001989488
  XXXXXXXX
  LIVE
  0001971543
  Mural Oncology plc
  001-41837
  10 Earlsfort Terrace
  Dublin 2
  L2
  D02 T380
  353-1-905-8020
  Loew Caroline
  Officer
  Director
  Ordinary Shares
  MorganStanley Private Bank
  Harborside 2
  200 Hudson Street, Suite 501
  Jersey City
  NJ
  07311
  12513
  30469
  17268881
  07/07/2025
  NASDAQ
  Ordinary Shares
  07/05/2025
  Restricted Stock Units
  Issuer
  N
  12513
  07/05/2025
  Equity Compensation
  Y
  Represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on Dcember 14, 2023. The automatic sale of the Reporting Person's shares is provided for in a restricted stock unit agreement that includes a "binding contract" consistent with the affirmative defense to liability uner Rule 10b5-1 that was entered on March 27, 2024, and the sale does not represent a discretionary trade by the Reporting Person.
  07/09/2025
  03/27/2024
  /s/ Caroline Loew