content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001567045</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001937653</issuerCik>
  <issuerName>Zymeworks Inc.</issuerName>
  <secFileNumber>001-41535</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">108 Patriot Drive</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite A</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Middletown</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">DE</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">19709</zipCode>
  </issuerAddress>
  <issuerContactPhone>302-274-8744</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Galbraith, Kenneth</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1585 Broadway</street1>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10036</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>57291</noOfUnitsSold>
  <aggregateMarketValue>828428</aggregateMarketValue>
  <noOfUnitsOutstanding>68877526</noOfUnitsOutstanding>
  <approxSaleDate>01/06/2025</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>01/06/2025</acquiredDate>
  <natureOfAcquisitionTransaction>Vesting of Restricted Stock Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>47666</amountOfSecuritiesAcquired>
  <paymentDate>01/06/2025</paymentDate>
  <natureOfPayment>Vesting of Award</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>01/06/2025</acquiredDate>
  <natureOfAcquisitionTransaction>Vesting of Restricted Stock Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>66666</amountOfSecuritiesAcquired>
  <paymentDate>01/06/2025</paymentDate>
  <natureOfPayment>Vesting of Award</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>The shares of common stock to be sold represent shares to be sold to cover tax withholding obligations and other fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the applicable RSU grant agreement.</remarks>
  <noticeSignature>
  <noticeDate>01/06/2025</noticeDate>
  <signature>/s/ Kenneth Galbraith</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3553}]
text: 144
  0001567045
  XXXXXXXX
  LIVE
  0001937653
  Zymeworks Inc.
  001-41535
  108 Patriot Drive
  Suite A
  Middletown
  DE
  19709
  302-274-8744
  Galbraith, Kenneth
  Officer
  Director
  Common Stock
  Morgan Stanley
  1585 Broadway
  New York
  NY
  10036
  57291
  828428
  68877526
  01/06/2025
  Nasdaq
  Common Stock
  01/06/2025
  Vesting of Restricted Stock Units
  Issuer
  N
  47666
  01/06/2025
  Vesting of Award
  Common Stock
  01/06/2025
  Vesting of Restricted Stock Units
  Issuer
  N
  66666
  01/06/2025
  Vesting of Award
  Y
  The shares of common stock to be sold represent shares to be sold to cover tax withholding obligations and other fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the applicable RSU grant agreement.
  01/06/2025
  /s/ Kenneth Galbraith