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  <ccc>XXXXXXXX</ccc>
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  <issuerName>Dyne Therapeutics, Inc.</issuerName>
  <secFileNumber>001-39509</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </issuerAddress>
  <issuerContactPhone>(781)-786-8230</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Richard Scalzo</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>E*Trade Financial Corporation</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 Edison Drive</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Alpharaetta</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
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  <noOfUnitsSold>2273</noOfUnitsSold>
  <aggregateMarketValue>58760</aggregateMarketValue>
  <noOfUnitsOutstanding>81958068</noOfUnitsOutstanding>
  <approxSaleDate>03/07/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>02/15/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Shares acquired upon vesting of restricted stock units granted pursuant to issuer's 2020 stock incentive plan</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2273</amountOfSecuritiesAcquired>
  <paymentDate>02/15/2024</paymentDate>
  <natureOfPayment>Equity compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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  <sellerDetails>
  <name>Richard Scalzo</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>12/11/2023</saleDate>
  <amountOfSecuritiesSold>1380</amountOfSecuritiesSold>
  <grossProceeds>14797</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Richard Scalzo</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>12/14/2023</saleDate>
  <amountOfSecuritiesSold>2376</amountOfSecuritiesSold>
  <grossProceeds>28558</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Richard Scalzo</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>01/03/2024</saleDate>
  <amountOfSecuritiesSold>13000</amountOfSecuritiesSold>
  <grossProceeds>244500</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Richard Scalzo</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>01/26/2024</saleDate>
  <amountOfSecuritiesSold>13000</amountOfSecuritiesSold>
  <grossProceeds>316441</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Richard Scalzo</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>02/29/2024</saleDate>
  <amountOfSecuritiesSold>3429</amountOfSecuritiesSold>
  <grossProceeds>94310</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Richard Scalzo</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>03/01/2024</saleDate>
  <amountOfSecuritiesSold>9311</amountOfSecuritiesSold>
  <grossProceeds>263005</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>Sale represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on November 15, 2023.</remarks>
  <noticeSignature>
  <noticeDate>03/07/2024</noticeDate>
  <signature>/s/ Richard Scalzo</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6610}]
text: 144
  0001789545
  XXXXXXXX
  LIVE
  0001818794
  Dyne Therapeutics, Inc.
  001-39509
  1560 Trapelo Road
  Waltham
  MA
  02451
  (781)-786-8230
  Richard Scalzo
  Officer
  Common Stock
  E*Trade Financial Corporation
  3 Edison Drive
  Alpharaetta
  GA
  30005
  2273
  58760
  81958068
  03/07/2024
  NASDAQ
  Common Stock
  02/15/2024
  Shares acquired upon vesting of restricted stock units granted pursuant to issuer's 2020 stock incentive plan
  Issuer
  N
  2273
  02/15/2024
  Equity compensation
  N
  Richard Scalzo
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  12/11/2023
  1380
  14797
  Richard Scalzo
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  12/14/2023
  2376
  28558
  Richard Scalzo
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  01/03/2024
  13000
  244500
  Richard Scalzo
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  01/26/2024
  13000
  316441
  Richard Scalzo
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  02/29/2024
  3429
  94310
  Richard Scalzo
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  03/01/2024
  9311
  263005
  Sale represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on November 15, 2023.
  03/07/2024
  /s/ Richard Scalzo