content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001779964</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001534969</issuerCik>
  <issuerName>Sera Prognostics, Inc.</issuerName>
  <secFileNumber>001-40606</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">2749 East Parleys Way</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 200</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Salt Lake City</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">UT</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">84109</zipCode>
  </issuerAddress>
  <issuerContactPhone>(801)-990-0520</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jackson Benjamin</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Class A Common</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Smith Barney LLC</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">38th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>4727</noOfUnitsSold>
  <aggregateMarketValue>34579</aggregateMarketValue>
  <noOfUnitsOutstanding>33772500</noOfUnitsOutstanding>
  <approxSaleDate>11/11/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Class A Common</securitiesClassTitle>
  <acquiredDate>11/11/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>4727</amountOfSecuritiesAcquired>
  <paymentDate>11/11/2024</paymentDate>
  <natureOfPayment>Not Applicable</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>The sale on this form represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by sell to cover transactions and does not represent a discretionary transaction by the Reporting Person.</remarks>
  <noticeSignature>
  <noticeDate>11/12/2024</noticeDate>
  <signature>/s/ Benjamin G. Jackson</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3249}]
text: 144
  0001779964
  XXXXXXXX
  LIVE
  0001534969
  Sera Prognostics, Inc.
  001-40606
  2749 East Parleys Way
  Suite 200
  Salt Lake City
  UT
  84109
  (801)-990-0520
  Jackson Benjamin
  Officer
  Class A Common
  Morgan Stanley Smith Barney LLC
  1 New York Plaza
  38th Floor
  New York
  NY
  10004
  4727
  34579
  33772500
  11/11/2024
  NASDAQ
  Class A Common
  11/11/2024
  Restricted Stock Unit Vesting
  Issuer
  N
  4727
  11/11/2024
  Not Applicable
  Y
  The sale on this form represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by sell to cover transactions and does not represent a discretionary transaction by the Reporting Person.
  11/12/2024
  /s/ Benjamin G. Jackson