content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001528185</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001159036</issuerCik>
        <issuerName>Halozyme Therapeutics, Inc.</issuerName>
        <secFileNumber>001-32335</secFileNumber>
        <issuerAddress>
          <com:street1>12390 El Camino Real</com:street1>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>858-794-8889</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Helen Torley</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>President, CEO, Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>240000</noOfUnitsSold>
        <aggregateMarketValue>12756000</aggregateMarketValue>
        <noOfUnitsOutstanding>123221000</noOfUnitsOutstanding>
        <approxSaleDate>06/20/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common  Stock</securitiesClassTitle>
        <acquiredDate>06/20/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>240000</amountOfSecuritiesAcquired>
        <paymentDate>06/20/2025</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>The shares covered by this filing are stock options that will be exercised within three months from the date of this filing.</remarks>
      <noticeSignature>
        <noticeDate>06/20/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>03/21/2025</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Helen Torley</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001528185
  XXXXXXXX
  LIVE
  0001159036
  Halozyme Therapeutics, Inc.
  001-32335
  12390 El Camino Real
  San Diego
  CA
  92130
  858-794-8889
  Helen Torley
  President, CEO, Director
  Common Stock
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  240000
  12756000
  123221000
  06/20/2025
  NASDAQ
  Common  Stock
  06/20/2025
  Stock Option Exercise
  Issuer
  N
  240000
  06/20/2025
  Cash
  Y
  The shares covered by this filing are stock options that will be exercised within three months from the date of this filing.
  06/20/2025
  03/21/2025
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Helen Torley