content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001805916</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001556263</issuerCik>
        <issuerName>Syros Pharmaceuticals</issuerName>
        <secFileNumber>001-37813</secFileNumber>
        <issuerAddress>
          <com:street1>35 Cambridge Park Drive</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02140</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>6177441340</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Flagship Pioneering Fund VII, L.P.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1000000</noOfUnitsSold>
        <aggregateMarketValue>230000</aggregateMarketValue>
        <noOfUnitsOutstanding>26832457</noOfUnitsOutstanding>
        <approxSaleDate>12/13/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>09/15/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Private Placement</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>700000</amountOfSecuritiesAcquired>
        <paymentDate>09/15/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>12/22/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Public Offering</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>300000</amountOfSecuritiesAcquired>
        <paymentDate>12/22/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/13/2024</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Flagship Pioneering Fund VII, L.P.</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3412}]
text: 144
  0001805916
  XXXXXXXX
  LIVE
  0001556263
  Syros Pharmaceuticals
  001-37813
  35 Cambridge Park Drive
  Cambridge
  MA
  02140
  6177441340
  Flagship Pioneering Fund VII, L.P.
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  1000000
  230000
  26832457
  12/13/2024
  Nasdaq
  Common
  09/15/2022
  Private Placement
  Issuer
  N
  700000
  09/15/2022
  Cash
  Common
  12/22/2023
  Public Offering
  Issuer
  N
  300000
  12/22/2023
  Cash
  Y
  12/13/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Flagship Pioneering Fund VII, L.P.