content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <!-- Field: Pseudo-Tag; ID: Name; Data: ORBIMED ADVISORS LLC -->
            <cik>0001055951</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001800315</issuerCik>
        <issuerName>Galecto</issuerName>
        <secFileNumber>001-39655</secFileNumber>
        <issuerAddress>
          <com:street1>75 State Street</com:street1>
          <com:street2>Suite 100</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02109</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>45-70-70-52-10</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>OrbiMed Genesis Master Fund, L.P.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Shareholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Themis Trading LLC</name>
          <address>
            <com:street1>10 Town Square</com:street1>
            <com:street2>Suite 100</com:street2>
            <com:city>Chatham</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07928</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1686</noOfUnitsSold>
        <aggregateMarketValue>3203.40</aggregateMarketValue>
        <noOfUnitsOutstanding>25673474</noOfUnitsOutstanding>
        <approxSaleDate>04/10/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq Stock Market</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>09/25/2020</acquiredDate>
        <natureOfAcquisitionTransaction>Private placement</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1686</amountOfSecuritiesAcquired>
        <paymentDate>09/25/2020</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>OrbiMed Genesis Master Fund, L.P.</name>
          <address>
            <com:street1>601 Lexington Ave.</com:street1>
            <com:street2>54th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10022</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>04/05/2023</saleDate>
        <amountOfSecuritiesSold>4687</amountOfSecuritiesSold>
        <grossProceeds>10217.66</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>OrbiMed Genesis GP LLC is the general partner of OrbiMed Genesis Master Fund, L.P. OrbiMed Advisors LLC is the managing member of OrbiMed Genesis GP LLC. Additional sales made on April 6, 2023. OrbiMed Genesis GP LLC sold 487 shares of Common Stock for gross proceeds of $974.</remarks>
      <noticeSignature>
        <noticeDate>04/10/2023</noticeDate>
        <signature>/s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors LLC, managing member of the general partner of OrbiMed Genesis Master Fund, L.P.</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3962}]
text: 144
  0001055951
  XXXXXXXX
  LIVE
  0001800315
  Galecto
  001-39655
  75 State Street
  Suite 100
  Boston
  MA
  02109
  45-70-70-52-10
  OrbiMed Genesis Master Fund, L.P.
  Shareholder
  Common Stock
  Themis Trading LLC
  10 Town Square
  Suite 100
  Chatham
  NJ
  07928
  1686
  3203.40
  25673474
  04/10/2023
  Nasdaq Stock Market
  Common Stock
  09/25/2020
  Private placement
  Issuer
  N
  1686
  09/25/2020
  Cash
  N
  OrbiMed Genesis Master Fund, L.P.
  601 Lexington Ave.
  54th Floor
  New York
  NY
  10022
  Common Stock
  04/05/2023
  4687
  10217.66
  OrbiMed Genesis GP LLC is the general partner of OrbiMed Genesis Master Fund, L.P. OrbiMed Advisors LLC is the managing member of OrbiMed Genesis GP LLC. Additional sales made on April 6, 2023. OrbiMed Genesis GP LLC sold 487 shares of Common Stock for gross proceeds of $974.
  04/10/2023
  /s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors LLC, managing member of the general partner of OrbiMed Genesis Master Fund, L.P.