content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001604097</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001288847</issuerCik>
  <issuerName>Five9, Inc.</issuerName>
  <secFileNumber>001-36383</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">3001 Bishop Drive</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 350</street2>
  <city xmlns="http://www.sec.gov/edgar/common">San Ramon</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">94583</zipCode>
  </issuerAddress>
  <issuerContactPhone>925-201-2000</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Michael Burkland</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">8th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>12595</noOfUnitsSold>
  <aggregateMarketValue>591965.00</aggregateMarketValue>
  <noOfUnitsOutstanding>74219203</noOfUnitsOutstanding>
  <approxSaleDate>06/04/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common</securitiesClassTitle>
  <acquiredDate>06/03/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>12595</amountOfSecuritiesAcquired>
  <paymentDate>06/03/2024</paymentDate>
  <natureOfPayment>Not Applicable</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Michael Burkland</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3001 Bishop Drive</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 350</street2>
  <city xmlns="http://www.sec.gov/edgar/common">San Ramon</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">94583</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common </securitiesClassTitle>
  <saleDate>03/04/2024</saleDate>
  <amountOfSecuritiesSold>9745</amountOfSecuritiesSold>
  <grossProceeds>605359.4</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Michael Burkland</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3001 Bishop Drive</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 350</street2>
  <city xmlns="http://www.sec.gov/edgar/common">San Ramon</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">94583</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common</securitiesClassTitle>
  <saleDate>03/05/2024</saleDate>
  <amountOfSecuritiesSold>36702</amountOfSecuritiesSold>
  <grossProceeds>2126234.94</grossProceeds>
  </securitiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>06/03/2024</noticeDate>
  <signature>Michael Burkland</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4166}]
text: 144
  0001604097
  XXXXXXXX
  LIVE
  0001288847
  Five9, Inc.
  001-36383
  3001 Bishop Drive
  Suite 350
  San Ramon
  CA
  94583
  925-201-2000
  Michael Burkland
  Officer
  Common Stock
  Morgan Stanley Smith Barney LLC Executive Financial Services
  1 New York Plaza
  8th Floor
  New York
  NY
  10004
  12595
  591965.00
  74219203
  06/04/2024
  NASDAQ
  Common
  06/03/2024
  Restricted Stock Units
  Issuer
  N
  12595
  06/03/2024
  Not Applicable
  N
  Michael Burkland
  3001 Bishop Drive
  Suite 350
  San Ramon
  CA
  94583
  Common
  03/04/2024
  9745
  605359.4
  Michael Burkland
  3001 Bishop Drive
  Suite 350
  San Ramon
  CA
  94583
  Common
  03/05/2024
  36702
  2126234.94
  06/03/2024
  Michael Burkland