content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001619961</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001582313</issuerCik>
  <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
  <secFileNumber>001-36687</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">3650 Gilmore Way</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Burnaby</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A1</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V5G 4W8</zipCode>
  </issuerAddress>
  <issuerContactPhone>(604)-484-3300</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>IAN MORTIMER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Canaccord Genuity Corp.</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1133 Melville St</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 1200</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Vancouver, BC</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">Z4</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V6E 4E5</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>16315</noOfUnitsSold>
  <aggregateMarketValue>660822.52</aggregateMarketValue>
  <noOfUnitsOutstanding>76239602</noOfUnitsOutstanding>
  <approxSaleDate>01/27/2025</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <acquiredDate>01/27/2025</acquiredDate>
  <natureOfAcquisitionTransaction>Exercise of Options</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>16315</amountOfSecuritiesAcquired>
  <paymentDate>01/27/2025</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Ian Mortimer</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3650 Gilmore Way</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Burnaby</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A1</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V5G 4W8</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <saleDate>01/23/2025</saleDate>
  <amountOfSecuritiesSold>16217</amountOfSecuritiesSold>
  <grossProceeds>649927.65</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Ian Mortimer</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3650 Gimore Way</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Burnaby</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A1</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V5G 4W8</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <saleDate>01/24/2025</saleDate>
  <amountOfSecuritiesSold>22468</amountOfSecuritiesSold>
  <grossProceeds>903299.07</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>The Common Shares reported on this Form 144 were obtained via the exercise of options scheduled to expire on March 16, 2025, and are being sold pursuant to a Rule 10b5-1 trading plan.</remarks>
  <noticeSignature>
  <noticeDate>01/27/2025</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>09/27/2024</planAdoptionDate>
  </planAdoptionDates>
  <signature>/s/ Ian Mortimer</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4286}]
text: 144
  0001619961
  XXXXXXXX
  LIVE
  0001582313
  Xenon Pharmaceuticals Inc.
  001-36687
  3650 Gilmore Way
  Burnaby
  A1
  V5G 4W8
  (604)-484-3300
  IAN MORTIMER
  Officer
  Director
  Common Shares
  Canaccord Genuity Corp.
  1133 Melville St
  Suite 1200
  Vancouver, BC
  Z4
  V6E 4E5
  16315
  660822.52
  76239602
  01/27/2025
  NASDAQ
  Common Shares
  01/27/2025
  Exercise of Options
  Issuer
  N
  16315
  01/27/2025
  Cash
  N
  Ian Mortimer
  3650 Gilmore Way
  Burnaby
  A1
  V5G 4W8
  Common Shares
  01/23/2025
  16217
  649927.65
  Ian Mortimer
  3650 Gimore Way
  Burnaby
  A1
  V5G 4W8
  Common Shares
  01/24/2025
  22468
  903299.07
  The Common Shares reported on this Form 144 were obtained via the exercise of options scheduled to expire on March 16, 2025, and are being sold pursuant to a Rule 10b5-1 trading plan.
  01/27/2025
  09/27/2024
  /s/ Ian Mortimer