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          <filerCredentials>
            <cik>0001590973</cik>
            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001556263</issuerCik>
        <issuerName>Syros Pharmaceuticals</issuerName>
        <secFileNumber>001-37813</secFileNumber>
        <issuerAddress>
          <com:street1>35 Cambridge Park Drive</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02140</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>6177441340</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Flagship Ventures Fund IV-RX, LP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
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      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>55925</noOfUnitsSold>
        <aggregateMarketValue>12863</aggregateMarketValue>
        <noOfUnitsOutstanding>26832457</noOfUnitsOutstanding>
        <approxSaleDate>12/13/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/09/2012</acquiredDate>
        <natureOfAcquisitionTransaction>Pre-IPO VC Stage Investment</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>5333</amountOfSecuritiesAcquired>
        <paymentDate>08/09/2012</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>04/10/2013</acquiredDate>
        <natureOfAcquisitionTransaction>Pre-IPO VC Stage Investment</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>26667</amountOfSecuritiesAcquired>
        <paymentDate>04/10/2013</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/28/2014</acquiredDate>
        <natureOfAcquisitionTransaction>Pre-IPO VC Stage Investment</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>23925</amountOfSecuritiesAcquired>
        <paymentDate>03/28/2014</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/13/2024</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Flagship Ventures Fund IV-RX, LP</signature>
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text: 144
  0001590973
  XXXXXXXX
  LIVE
  0001556263
  Syros Pharmaceuticals
  001-37813
  35 Cambridge Park Drive
  Cambridge
  MA
  02140
  6177441340
  Flagship Ventures Fund IV-RX, LP
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  55925
  12863
  26832457
  12/13/2024
  Nasdaq
  Common
  08/09/2012
  Pre-IPO VC Stage Investment
  Issuer
  N
  5333
  08/09/2012
  Cash
  Common
  04/10/2013
  Pre-IPO VC Stage Investment
  Issuer
  N
  26667
  04/10/2013
  Cash
  Common
  03/28/2014
  Pre-IPO VC Stage Investment
  Issuer
  N
  23925
  03/28/2014
  Cash
  Y
  12/13/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Flagship Ventures Fund IV-RX, LP