content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001398764</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001815442</issuerCik>
  <issuerName>KYMERA THERAPEUTICS, INC.</issuerName>
  <secFileNumber>001-39460</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">500 North Beacon Street</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">4th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Watertown</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02472</zipCode>
  </issuerAddress>
  <issuerContactPhone>(857)-285-5300</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Chiniara Ellen</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Smith Barney LLC</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">38th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>2241</noOfUnitsSold>
  <aggregateMarketValue>70255</aggregateMarketValue>
  <noOfUnitsOutstanding>64944136</noOfUnitsOutstanding>
  <approxSaleDate>03/03/2025</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/03/2025</acquiredDate>
  <natureOfAcquisitionTransaction>Shares acquired upon vesting of Restricted Stock Units awarded under the Issuer's 2020 Equity Incentive Plan.</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>KYMERA THERAPEUTICS, INC.</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2241</amountOfSecuritiesAcquired>
  <paymentDate>03/03/2025</paymentDate>
  <natureOfPayment>Equity compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Ellen Chiniara</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">500 North Beacon Street</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">4th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Watertown</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02472</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>01/06/2025</saleDate>
  <amountOfSecuritiesSold>3129</amountOfSecuritiesSold>
  <grossProceeds>130645</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>The sales reported on this Form 144 represent shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of RSUs. These sales were automatic and intended to qualify under Rule 10b5-1.</remarks>
  <noticeSignature>
  <noticeDate>03/03/2025</noticeDate>
  <signature>/s/ Ellen Chiniara</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3865}]
text: 144
  0001398764
  XXXXXXXX
  LIVE
  0001815442
  KYMERA THERAPEUTICS, INC.
  001-39460
  500 North Beacon Street
  4th Floor
  Watertown
  MA
  02472
  (857)-285-5300
  Chiniara Ellen
  Officer
  Common Stock
  Morgan Stanley Smith Barney LLC
  1 New York Plaza
  38th Floor
  New York
  NY
  10004
  2241
  70255
  64944136
  03/03/2025
  NASDAQ
  Common Stock
  03/03/2025
  Shares acquired upon vesting of Restricted Stock Units awarded under the Issuer's 2020 Equity Incentive Plan.
  KYMERA THERAPEUTICS, INC.
  N
  2241
  03/03/2025
  Equity compensation
  N
  Ellen Chiniara
  500 North Beacon Street
  4th Floor
  Watertown
  MA
  02472
  Common Stock
  01/06/2025
  3129
  130645
  The sales reported on this Form 144 represent shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of RSUs. These sales were automatic and intended to qualify under Rule 10b5-1.
  03/03/2025
  /s/ Ellen Chiniara