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            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001609550</issuerCik>
        <issuerName>Inspire Medical Systems, Inc.</issuerName>
        <secFileNumber>001-38468</secFileNumber>
        <issuerAddress>
          <com:street1>5500 WAYZATA BLVD</com:street1>
          <com:street2>SUITE 1600</com:street2>
          <com:city>GOLDEN VALLEY</com:city>
          <com:stateOrCountry>MN</com:stateOrCountry>
          <com:zipCode>55416</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>763-957-5037</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Buchholz Richard</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>RBC WEALTH MANAGEMENT</name>
          <address>
            <com:street1>250 NICOLLET MALL, SUITE 1700</com:street1>
            <com:city>MINNEAPOLIS</com:city>
            <com:stateOrCountry>MN</com:stateOrCountry>
            <com:zipCode>55401</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>15000</noOfUnitsSold>
        <aggregateMarketValue>3450510.00</aggregateMarketValue>
        <noOfUnitsOutstanding>29524189</noOfUnitsOutstanding>
        <approxSaleDate>04/17/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <acquiredDate>09/28/2021</acquiredDate>
        <natureOfAcquisitionTransaction>STOCK OPTION EXERCISE</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>4255</amountOfSecuritiesAcquired>
        <paymentDate>09/28/2021</paymentDate>
        <natureOfPayment>CHECK</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <acquiredDate>03/12/2021</acquiredDate>
        <natureOfAcquisitionTransaction>STOCK OPTION EXERCISE</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>10745</amountOfSecuritiesAcquired>
        <paymentDate>03/12/2021</paymentDate>
        <natureOfPayment>CHECK</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>SOLD PURSUANT TO A RULE 10B5-1 PLAN ESTABLISHED 08/31/2023</remarks>
      <noticeSignature>
        <noticeDate>04/17/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>08/31/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>POA / JEFFREY EISCHENS</signature>
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text: 144
  0001737133
  XXXXXXXX
  LIVE
  0001609550
  Inspire Medical Systems, Inc.
  001-38468
  5500 WAYZATA BLVD
  SUITE 1600
  GOLDEN VALLEY
  MN
  55416
  763-957-5037
  Buchholz Richard
  Officer
  COMMON
  RBC WEALTH MANAGEMENT
  250 NICOLLET MALL, SUITE 1700
  MINNEAPOLIS
  MN
  55401
  15000
  3450510.00
  29524189
  04/17/2024
  NYSE
  COMMON
  09/28/2021
  STOCK OPTION EXERCISE
  ISSUER
  N
  4255
  09/28/2021
  CHECK
  COMMON
  03/12/2021
  STOCK OPTION EXERCISE
  ISSUER
  N
  10745
  03/12/2021
  CHECK
  Y
  SOLD PURSUANT TO A RULE 10B5-1 PLAN ESTABLISHED 08/31/2023
  04/17/2024
  08/31/2023
  POA / JEFFREY EISCHENS