content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001873905</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001841387</issuerCik>
  <issuerName>CANDEL THERAPEUTICS, INC.</issuerName>
  <secFileNumber>001-40629</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">117 Kendrick St</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 450</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Needham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02494</zipCode>
  </issuerAddress>
  <issuerContactPhone>617-916-5445</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Tak Paul Peter</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Smith Barney</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">2000 Westchester Ave</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Purchase</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10577-2530</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>44433</noOfUnitsSold>
  <aggregateMarketValue>219943.35</aggregateMarketValue>
  <noOfUnitsOutstanding>32475537</noOfUnitsOutstanding>
  <approxSaleDate>11/29/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>11/28/2022</acquiredDate>
  <natureOfAcquisitionTransaction>RSU Award</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Candel Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>44433</amountOfSecuritiesAcquired>
  <paymentDate>11/28/2022</paymentDate>
  <natureOfPayment>Not Applicable</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>The sales reported on this Form 144 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units pursuant to the Issuer's mandatory sell to cover policy, which requires sales in an amount sufficient to cover tax withholding obligations associated with the vesting events, and the sales do not represent discretionary sales by the Reporting Person.</remarks>
  <noticeSignature>
  <noticeDate>11/29/2024</noticeDate>
  <signature>/s/ Charles Schoch, as Attorney-in-Fact for Paul Peter Tak</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3315}]
text: 144
  0001873905
  XXXXXXXX
  LIVE
  0001841387
  CANDEL THERAPEUTICS, INC.
  001-40629
  117 Kendrick St
  Suite 450
  Needham
  MA
  02494
  617-916-5445
  Tak Paul Peter
  Officer
  Director
  Common Stock
  Morgan Stanley Smith Barney
  2000 Westchester Ave
  Purchase
  NY
  10577-2530
  44433
  219943.35
  32475537
  11/29/2024
  NASDAQ
  Common Stock
  11/28/2022
  RSU Award
  Candel Therapeutics, Inc.
  N
  44433
  11/28/2022
  Not Applicable
  Y
  The sales reported on this Form 144 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units pursuant to the Issuer's mandatory sell to cover policy, which requires sales in an amount sufficient to cover tax withholding obligations associated with the vesting events, and the sales do not represent discretionary sales by the Reporting Person.
  11/29/2024
  /s/ Charles Schoch, as Attorney-in-Fact for Paul Peter Tak