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  <issuerName>Tango Therapeutics, Inc.</issuerName>
  <secFileNumber>001-39485</secFileNumber>
  <issuerAddress>
  <com:street1>201 Brookline Ave</com:street1>
  <com:street2>Suite 901</com:street2>
  <com:city>Boston</com:city>
  <com:stateOrCountry>MA</com:stateOrCountry>
  <com:zipCode>02215</com:zipCode>
  </issuerAddress>
  <issuerContactPhone>857-320-4900</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MVA Investors, LLC</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Member of group owning over 10% of the shares</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Interactive Brokers LLC</name>
  <address>
  <com:street1>2 Pickwick Plaza</com:street1>
  <com:city>Greenwich</com:city>
  <com:stateOrCountry>CT</com:stateOrCountry>
  <com:zipCode>06830</com:zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>50000</noOfUnitsSold>
  <aggregateMarketValue>569000</aggregateMarketValue>
  <noOfUnitsOutstanding>101738444</noOfUnitsOutstanding>
  <approxSaleDate>10/09/2023</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>04/07/2020</acquiredDate>
  <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Tango Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>9360</amountOfSecuritiesAcquired>
  <paymentDate>04/07/2020</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>08/07/2020</acquiredDate>
  <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Tango Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>40640</amountOfSecuritiesAcquired>
  <paymentDate>08/07/2020</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>10/09/2023</noticeDate>
  <signature>/s/ Aaron Davis, Chief Executive Officer</signature>
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text: 144
  0001468223
  XXXXXXXX
  LIVE
  0001819133
  Tango Therapeutics, Inc.
  001-39485
  201 Brookline Ave
  Suite 901
  Boston
  MA
  02215
  857-320-4900
  MVA Investors, LLC
  Member of group owning over 10% of the shares
  Common Stock
  Interactive Brokers LLC
  2 Pickwick Plaza
  Greenwich
  CT
  06830
  50000
  569000
  101738444
  10/09/2023
  Nasdaq
  Common Stock
  04/07/2020
  Private Financing
  Tango Therapeutics, Inc.
  N
  9360
  04/07/2020
  Cash
  Common Stock
  08/07/2020
  Private Financing
  Tango Therapeutics, Inc.
  N
  40640
  08/07/2020
  Cash
  Y
  10/09/2023
  /s/ Aaron Davis, Chief Executive Officer