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            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerName>Syros Pharmaceuticals</issuerName>
        <secFileNumber>001-37813</secFileNumber>
        <issuerAddress>
          <com:street1>35 Cambridge Park Drive</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02140</com:zipCode>
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        <issuerContactPhone>6177441340</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Flagship VentureLabs IV LLC</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
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        <noOfUnitsSold>21333</noOfUnitsSold>
        <aggregateMarketValue>4907</aggregateMarketValue>
        <noOfUnitsOutstanding>26832457</noOfUnitsOutstanding>
        <approxSaleDate>12/13/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>06/29/2012</acquiredDate>
        <natureOfAcquisitionTransaction>Pre-IPO VC Stage Investment</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>21333</amountOfSecuritiesAcquired>
        <paymentDate>06/29/2012</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>12/13/2024</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Flagship VentureLabs IV LLC</signature>
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text: 144
  0001642578
  XXXXXXXX
  LIVE
  0001556263
  Syros Pharmaceuticals
  001-37813
  35 Cambridge Park Drive
  Cambridge
  MA
  02140
  6177441340
  Flagship VentureLabs IV LLC
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  21333
  4907
  26832457
  12/13/2024
  Nasdaq
  Common
  06/29/2012
  Pre-IPO VC Stage Investment
  Issuer
  N
  21333
  06/29/2012
  Cash
  Y
  12/13/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Flagship VentureLabs IV LLC