content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001779479</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001744659</issuerCik>
        <issuerName>Akero Therapeutics</issuerName>
        <secFileNumber>001-38944</secFileNumber>
        <issuerAddress>
          <com:street1>601 Gateway Blvd., Suite 350</com:street1>
          <com:city>South San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>650-487-6488</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Timothy Rolph</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>50000</noOfUnitsSold>
        <aggregateMarketValue>2000000</aggregateMarketValue>
        <noOfUnitsOutstanding>79620128</noOfUnitsOutstanding>
        <approxSaleDate>05/06/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>05/06/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
        <paymentDate>05/06/2025</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Timothy Rolph</name>
          <address>
            <com:street1>C/o Akero Therapeutics, Inc.</com:street1>
            <com:street2>601 Gateway Boulevard, Suite 350</com:street2>
            <com:city>South San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>03/05/2025</saleDate>
        <amountOfSecuritiesSold>12500</amountOfSecuritiesSold>
        <grossProceeds>556594</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Timothy Rolph</name>
          <address>
            <com:street1>C/o Akero Therapeutics, Inc.</com:street1>
            <com:street2>601 Gateway Boulevard, Suite 350</com:street2>
            <com:city>South San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>04/07/2025</saleDate>
        <amountOfSecuritiesSold>6250</amountOfSecuritiesSold>
        <grossProceeds>224260</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Timothy Rolph</name>
          <address>
            <com:street1>C/o Akero Therapeutics, Inc.</com:street1>
            <com:street2>601 Gateway Boulevard, Suite 350</com:street2>
            <com:city>South San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94080</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>04/24/2025</saleDate>
        <amountOfSecuritiesSold>6250</amountOfSecuritiesSold>
        <grossProceeds>256442</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>The sales under this filing are from Cashless Option Exercises that will occur within 3 months from the date of this filing.</remarks>
      <noticeSignature>
        <noticeDate>05/06/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>08/12/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Timothy Rolph</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001779479
  XXXXXXXX
  LIVE
  0001744659
  Akero Therapeutics
  001-38944
  601 Gateway Blvd., Suite 350
  South San Francisco
  CA
  94080
  650-487-6488
  Timothy Rolph
  Officer
  Common Stock
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  50000
  2000000
  79620128
  05/06/2025
  NASDAQ
  Common Stock
  05/06/2025
  Stock Option Exercise
  Issuer
  N
  50000
  05/06/2025
  Compensation
  N
  Timothy Rolph
  C/o Akero Therapeutics, Inc.
  601 Gateway Boulevard, Suite 350
  South San Francisco
  CA
  94080
  Common Stock
  03/05/2025
  12500
  556594
  Timothy Rolph
  C/o Akero Therapeutics, Inc.
  601 Gateway Boulevard, Suite 350
  South San Francisco
  CA
  94080
  Common Stock
  04/07/2025
  6250
  224260
  Timothy Rolph
  C/o Akero Therapeutics, Inc.
  601 Gateway Boulevard, Suite 350
  South San Francisco
  CA
  94080
  Common Stock
  04/24/2025
  6250
  256442
  The sales under this filing are from Cashless Option Exercises that will occur within 3 months from the date of this filing.
  05/06/2025
  08/12/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Timothy Rolph