content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
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  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001722673</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001971543</issuerCik>
  <issuerName>Mural Oncology plc</issuerName>
  <secFileNumber>001-41837</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">10 Earlsfort Terrace</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Dublin 2</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">L2</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">D02 T380</zipCode>
  </issuerAddress>
  <issuerContactPhone>353-1-905-8020</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Cutler Adam D.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Ordinary Shares</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>MorganStanley Private Bank</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">Harborside 2</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">200 Hudson Street, Suite 501</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Jersey City</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NJ</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">07311</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>7421</noOfUnitsSold>
  <aggregateMarketValue>25306</aggregateMarketValue>
  <noOfUnitsOutstanding>17040595</noOfUnitsOutstanding>
  <approxSaleDate>10/31/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Ordinary Shares</securitiesClassTitle>
  <acquiredDate>10/30/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>7421</amountOfSecuritiesAcquired>
  <paymentDate>10/30/2024</paymentDate>
  <natureOfPayment>Equity Compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>Represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on December 14, 2023. The automatic sale of the Reporting Person's shares is provided for in a restricted stock unit agreement that includes a "binding contract" consistent with the affirmative defense to liability uner Rule 10b5-1 that was entered on January 12, 2024, and the sale does not represent a discretionary trade by the Reporting Person.</remarks>
  <noticeSignature>
  <noticeDate>11/01/2024</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>01/12/2024</planAdoptionDate>
  </planAdoptionDates>
  <signature>/s/ Adam Cutler</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
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text: 144
  0001722673
  XXXXXXXX
  LIVE
  0001971543
  Mural Oncology plc
  001-41837
  10 Earlsfort Terrace
  Dublin 2
  L2
  D02 T380
  353-1-905-8020
  Cutler Adam D.
  Officer
  Ordinary Shares
  MorganStanley Private Bank
  Harborside 2
  200 Hudson Street, Suite 501
  Jersey City
  NJ
  07311
  7421
  25306
  17040595
  10/31/2024
  NASDAQ
  Ordinary Shares
  10/30/2024
  Restricted Stock Units
  Issuer
  N
  7421
  10/30/2024
  Equity Compensation
  Y
  Represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on December 14, 2023. The automatic sale of the Reporting Person's shares is provided for in a restricted stock unit agreement that includes a "binding contract" consistent with the affirmative defense to liability uner Rule 10b5-1 that was entered on January 12, 2024, and the sale does not represent a discretionary trade by the Reporting Person.
  11/01/2024
  01/12/2024
  /s/ Adam Cutler