content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001657765</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001631574</issuerCik>
  <issuerName>Wave Life Sciences Ltd.</issuerName>
  <secFileNumber>001-37627</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">7 Straits View #12-00</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Marina One East Tower</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Singapore</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">U0</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">018936</zipCode>
  </issuerAddress>
  <issuerContactPhone>65-6236 3388</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KYLE MORAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>common</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">8th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>17146</noOfUnitsSold>
  <aggregateMarketValue>154314.00</aggregateMarketValue>
  <noOfUnitsOutstanding>124737862</noOfUnitsOutstanding>
  <approxSaleDate>09/25/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>common</securitiesClassTitle>
  <acquiredDate>02/15/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>17146</amountOfSecuritiesAcquired>
  <paymentDate>02/15/2023</paymentDate>
  <natureOfPayment>Not Applicable</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>The sales reported in this Form 144 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 21, 2023.</remarks>
  <noticeSignature>
  <noticeDate>09/25/2024</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>11/21/2023</planAdoptionDate>
  </planAdoptionDates>
  <signature>Kyle Moran</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3073}]
text: 144
  0001657765
  XXXXXXXX
  LIVE
  0001631574
  Wave Life Sciences Ltd.
  001-37627
  7 Straits View #12-00
  Marina One East Tower
  Singapore
  U0
  018936
  65-6236 3388
  KYLE MORAN
  Officer
  common
  Morgan Stanley Smith Barney LLC Executive Financial Services
  1 New York Plaza
  8th Floor
  New York
  NY
  10004
  17146
  154314.00
  124737862
  09/25/2024
  NASDAQ
  common
  02/15/2023
  Restricted Stock
  ISSUER
  N
  17146
  02/15/2023
  Not Applicable
  Y
  The sales reported in this Form 144 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 21, 2023.
  09/25/2024
  11/21/2023
  Kyle Moran