content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001695625</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001142417</issuerCik>
  <issuerName>NEXSTAR MEDIA GROUP, INC.</issuerName>
  <secFileNumber>000-50478</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">545 E. John Carpenter Freeway</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 700</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Irving</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">TX</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">75062</zipCode>
  </issuerAddress>
  <issuerContactPhone> 972-373-8800</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jenkins Brett </nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>E*TRADE from Morgan Stanley</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">PO Box 484</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Jersey City</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NJ</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">07303-0484</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>3785</noOfUnitsSold>
  <aggregateMarketValue>668988</aggregateMarketValue>
  <noOfUnitsOutstanding>30509206</noOfUnitsOutstanding>
  <approxSaleDate>03/19/2025</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/15/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2642</amountOfSecuritiesAcquired>
  <paymentDate>03/15/2022</paymentDate>
  <natureOfPayment>Compensation</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/20/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>1143</amountOfSecuritiesAcquired>
  <paymentDate>03/20/2022</paymentDate>
  <natureOfPayment>Compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>03/19/2025</noticeDate>
  <signature>/s/ Brett Jenkins</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3228}]
text: 144
  0001695625
  XXXXXXXX
  LIVE
  0001142417
  NEXSTAR MEDIA GROUP, INC.
  000-50478
  545 E. John Carpenter Freeway
  Suite 700
  Irving
  TX
  75062
  972-373-8800
  Jenkins Brett
  Officer
  Common Stock
  E*TRADE from Morgan Stanley
  PO Box 484
  Jersey City
  NJ
  07303-0484
  3785
  668988
  30509206
  03/19/2025
  NASDAQ
  Common Stock
  03/15/2022
  Restricted Stock Vesting
  Issuer
  N
  2642
  03/15/2022
  Compensation
  Common Stock
  03/20/2022
  Restricted Stock Vesting
  Issuer
  N
  1143
  03/20/2022
  Compensation
  Y
  03/19/2025
  /s/ Brett Jenkins