content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001793102</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001177702</issuerCik>
  <issuerName>Saia, Inc.</issuerName>
  <secFileNumber>000-49983</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">11465 Johns Creek Parkway</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Johns Creek			</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30097</zipCode>
  </issuerAddress>
  <issuerContactPhone>770-232-5067</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Donna E. Epps								</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Ameriprise</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">70400 Ameriprise Financial Center</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Minneapolis</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MN</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">55474</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>240</noOfUnitsSold>
  <aggregateMarketValue>70430</aggregateMarketValue>
  <noOfUnitsOutstanding>26532778</noOfUnitsOutstanding>
  <approxSaleDate>05/08/2023</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common</securitiesClassTitle>
  <acquiredDate>11/14/2019</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Saia, Inc.</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>520</amountOfSecuritiesAcquired>
  <paymentDate>11/04/2019</paymentDate>
  <natureOfPayment>None</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Donna E. Epps</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">11465 Johns Creek Parkway</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 400</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Johns Creek</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30097</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>02/07/2023</saleDate>
  <amountOfSecuritiesSold>170</amountOfSecuritiesSold>
  <grossProceeds>49994.77</grossProceeds>
  </securitiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>05/08/2023</noticeDate>
  <signature>Donna E. Epps</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3330}]
text: 144
  0001793102
  XXXXXXXX
  LIVE
  0001177702
  Saia, Inc.
  000-49983
  11465 Johns Creek Parkway
  Johns Creek
  GA
  30097
  770-232-5067
  Donna E. Epps
  Director
  Common
  Ameriprise
  70400 Ameriprise Financial Center
  Minneapolis
  MN
  55474
  240
  70430
  26532778
  05/08/2023
  Nasdaq
  Common
  11/14/2019
  Restricted Stock Vesting
  Saia, Inc.
  N
  520
  11/04/2019
  None
  N
  Donna E. Epps
  11465 Johns Creek Parkway
  Suite 400
  Johns Creek
  GA
  30097
  Common Stock
  02/07/2023
  170
  49994.77
  05/08/2023
  Donna E. Epps