content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001421563</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001534969</issuerCik>
  <issuerName>Sera Prognostics, Inc.</issuerName>
  <secFileNumber>001-40606</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">2749 East Parleys Way</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 200</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Salt Lake City</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">UT</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">84109</zipCode>
  </issuerAddress>
  <issuerContactPhone>(801)-990-0520</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Harrison Robert Gardner</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Class A Common</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Smith Barney LLC</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">38th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>3251</noOfUnitsSold>
  <aggregateMarketValue>13537</aggregateMarketValue>
  <noOfUnitsOutstanding>33772500</noOfUnitsOutstanding>
  <approxSaleDate>03/06/2025</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Class A Common</securitiesClassTitle>
  <acquiredDate>03/06/2025</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>3251</amountOfSecuritiesAcquired>
  <paymentDate>03/06/2025</paymentDate>
  <natureOfPayment>Not Applicable</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Robert Harrison</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">2749 E. Parleys Way</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 200</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Salt Lake City</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">UT</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">84109</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Class A Common</securitiesClassTitle>
  <saleDate>01/10/2025</saleDate>
  <amountOfSecuritiesSold>14209</amountOfSecuritiesSold>
  <grossProceeds>105090</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Robert Harrison</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">2749 E. Parleys Way</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 200</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Salt Lake City</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">UT</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">84109</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Class A Common</securitiesClassTitle>
  <saleDate>01/13/2025</saleDate>
  <amountOfSecuritiesSold>2264</amountOfSecuritiesSold>
  <grossProceeds>14639</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Robert Harrison</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">2749 E. Parleys Way</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 200</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Salt Lake City</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">UT</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">84109</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Class A Common</securitiesClassTitle>
  <saleDate>02/06/2025</saleDate>
  <amountOfSecuritiesSold>554</amountOfSecuritiesSold>
  <grossProceeds>2465</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Robert Harrison</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">2749 E. Parleys Way</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 200</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Salt Lake City</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">UT</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">84109</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Class A Common</securitiesClassTitle>
  <saleDate>02/12/2025</saleDate>
  <amountOfSecuritiesSold>7297</amountOfSecuritiesSold>
  <grossProceeds>33390</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Robert Harrison</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">2749 E. Parleys Way</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 200</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Salt Lake City</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">UT</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">84109</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Class A Common</securitiesClassTitle>
  <saleDate>02/13/2025</saleDate>
  <amountOfSecuritiesSold>3610</amountOfSecuritiesSold>
  <grossProceeds>15454</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>The sale on this form represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by sell to cover transactions and does not represent a discretionary transaction by the Reporting Person.</remarks>
  <noticeSignature>
  <noticeDate>03/07/2025</noticeDate>
  <signature>/s/ Robert Harrison</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6672}]
text: 144
  0001421563
  XXXXXXXX
  LIVE
  0001534969
  Sera Prognostics, Inc.
  001-40606
  2749 East Parleys Way
  Suite 200
  Salt Lake City
  UT
  84109
  (801)-990-0520
  Harrison Robert Gardner
  Officer
  Class A Common
  Morgan Stanley Smith Barney LLC
  1 New York Plaza
  38th Floor
  New York
  NY
  10004
  3251
  13537
  33772500
  03/06/2025
  NASDAQ
  Class A Common
  03/06/2025
  Restricted Stock Unit Vesting
  Issuer
  N
  3251
  03/06/2025
  Not Applicable
  N
  Robert Harrison
  2749 E. Parleys Way
  Suite 200
  Salt Lake City
  UT
  84109
  Class A Common
  01/10/2025
  14209
  105090
  Robert Harrison
  2749 E. Parleys Way
  Suite 200
  Salt Lake City
  UT
  84109
  Class A Common
  01/13/2025
  2264
  14639
  Robert Harrison
  2749 E. Parleys Way
  Suite 200
  Salt Lake City
  UT
  84109
  Class A Common
  02/06/2025
  554
  2465
  Robert Harrison
  2749 E. Parleys Way
  Suite 200
  Salt Lake City
  UT
  84109
  Class A Common
  02/12/2025
  7297
  33390
  Robert Harrison
  2749 E. Parleys Way
  Suite 200
  Salt Lake City
  UT
  84109
  Class A Common
  02/13/2025
  3610
  15454
  The sale on this form represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by sell to cover transactions and does not represent a discretionary transaction by the Reporting Person.
  03/07/2025
  /s/ Robert Harrison