content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001651323</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001321732</issuerCik>
        <issuerName>Penumbra Inc.</issuerName>
        <secFileNumber>001-37557</secFileNumber>
        <issuerAddress>
          <com:street1>One Penumbra Place</com:street1>
          <com:city>Alameda</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94502</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>510-748-3200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Adam Elsesser</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>30000</noOfUnitsSold>
        <aggregateMarketValue>7113300</aggregateMarketValue>
        <noOfUnitsOutstanding>38379199</noOfUnitsOutstanding>
        <approxSaleDate>11/20/2024</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>08/13/2018</acquiredDate>
        <natureOfAcquisitionTransaction>Transfer of shares from Adam Elsessr who acquired from Issuer on 06/22/15 via option exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Adam Elsesser</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>30000</amountOfSecuritiesAcquired>
        <paymentDate>08/11/2023</paymentDate>
        <natureOfPayment>Transfer</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Siegel/Elsesser Revocable Trust</name>
          <address>
            <com:street1>Care of Penumbra Inc</com:street1>
            <com:street2>One Penumbra Place</com:street2>
            <com:city>Alameda</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94502</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>08/22/2024</saleDate>
        <amountOfSecuritiesSold>1620</amountOfSecuritiesSold>
        <grossProceeds>324007</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Siegel/Elsesser Revocable Trust</name>
          <address>
            <com:street1>Care of Penumbra Inc</com:street1>
            <com:street2>One Penumbra Place</com:street2>
            <com:city>Alameda</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94502</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>08/23/2024</saleDate>
        <amountOfSecuritiesSold>28380</amountOfSecuritiesSold>
        <grossProceeds>5771550</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Siegel/Elsesser Revocable Trust</name>
          <address>
            <com:street1>Care of Penumbra Inc</com:street1>
            <com:street2>One Penumbra Place</com:street2>
            <com:city>Alameda</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94502</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>09/20/2024</saleDate>
        <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
        <grossProceeds>2965620</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Siegel/Elsesser Revocable Trust</name>
          <address>
            <com:street1>Care of Penumbra Inc</com:street1>
            <com:street2>One Penumbra Place</com:street2>
            <com:city>Alameda</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94502</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>10/21/2024</saleDate>
        <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
        <grossProceeds>3068381</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>This filing represents shares being sold by Adam Elsesser, as trustee for the Siegel Elsesser Revocable Trust</remarks>
      <noticeSignature>
        <noticeDate>11/20/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>11/29/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Adam Elsesser</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5734}]
text: 144
  0001651323
  XXXXXXXX
  LIVE
  0001321732
  Penumbra Inc.
  001-37557
  One Penumbra Place
  Alameda
  CA
  94502
  510-748-3200
  Adam Elsesser
  Affiliate
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  New York
  NY
  10017
  30000
  7113300
  38379199
  11/20/2024
  NYSE
  Common
  08/13/2018
  Transfer of shares from Adam Elsessr who acquired from Issuer on 06/22/15 via option exercise
  Adam Elsesser
  N
  30000
  08/11/2023
  Transfer
  N
  Siegel/Elsesser Revocable Trust
  Care of Penumbra Inc
  One Penumbra Place
  Alameda
  CA
  94502
  Common
  08/22/2024
  1620
  324007
  Siegel/Elsesser Revocable Trust
  Care of Penumbra Inc
  One Penumbra Place
  Alameda
  CA
  94502
  Common
  08/23/2024
  28380
  5771550
  Siegel/Elsesser Revocable Trust
  Care of Penumbra Inc
  One Penumbra Place
  Alameda
  CA
  94502
  Common
  09/20/2024
  15000
  2965620
  Siegel/Elsesser Revocable Trust
  Care of Penumbra Inc
  One Penumbra Place
  Alameda
  CA
  94502
  Common
  10/21/2024
  15000
  3068381
  This filing represents shares being sold by Adam Elsesser, as trustee for the Siegel Elsesser Revocable Trust
  11/20/2024
  11/29/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Adam Elsesser