content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001870610</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  
  
  
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001484612</issuerCik>
  <issuerName>Outset Medical, Inc.</issuerName>
  <secFileNumber>001-39513</secFileNumber>
  <issuerAddress>
  <com:street1>3052 Orchard Drive</com:street1>
  <com:city>San Jose</com:city>
  <com:stateOrCountry>CA</com:stateOrCountry>
  <com:zipCode>95134</com:zipCode>
  </issuerAddress>
  <issuerContactPhone>669-231-8200</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Ahmed Nabeel</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Smith Barney LLC</name>
  <address>
  <com:street1>1 New York Plaza, 38th Floor</com:street1>
  <com:city>New York</com:city>
  <com:stateOrCountry>NY</com:stateOrCountry>
  <com:zipCode>10004</com:zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>1726</noOfUnitsSold>
  <aggregateMarketValue>7404.54</aggregateMarketValue>
  <noOfUnitsOutstanding>50204570</noOfUnitsOutstanding>
  <approxSaleDate>01/16/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>01/12/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Settlement of Vested Performance Stock Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2952</amountOfSecuritiesAcquired>
  <paymentDate>01/12/2024</paymentDate>
  <natureOfPayment>Equity compensation for services rendered</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Nabeel Ahmed</name>
  <address>
  <com:street1>3052 Orchard Drive</com:street1>
  <com:city>San Jose</com:city>
  <com:stateOrCountry>CA</com:stateOrCountry>
  <com:zipCode>95134</com:zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>11/16/2023</saleDate>
  <amountOfSecuritiesSold>1643</amountOfSecuritiesSold>
  <grossProceeds>7820.68</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Nabeel Ahmed</name>
  <address>
  <com:street1>3052 Orchard Drive</com:street1>
  <com:city>San Jose</com:city>
  <com:stateOrCountry>CA</com:stateOrCountry>
  <com:zipCode>95134</com:zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>01/08/2024</saleDate>
  <amountOfSecuritiesSold>10709</amountOfSecuritiesSold>
  <grossProceeds>58792.41</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>Shares sold to cover tax withholding obligations in connection with the vesting of Performance Stock Units. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.</remarks>
  <noticeSignature>
  <noticeDate>01/16/2024</noticeDate>
  <signature>John Brottem POA for Nabeel Ahmed</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3675}]
text: 144
  0001870610
  XXXXXXXX
  LIVE
  0001484612
  Outset Medical, Inc.
  001-39513
  3052 Orchard Drive
  San Jose
  CA
  95134
  669-231-8200
  Ahmed Nabeel
  Officer
  Common Stock
  Morgan Stanley Smith Barney LLC
  1 New York Plaza, 38th Floor
  New York
  NY
  10004
  1726
  7404.54
  50204570
  01/16/2024
  NASDAQ
  Common Stock
  01/12/2024
  Settlement of Vested Performance Stock Units
  Issuer
  N
  2952
  01/12/2024
  Equity compensation for services rendered
  N
  Nabeel Ahmed
  3052 Orchard Drive
  San Jose
  CA
  95134
  Common Stock
  11/16/2023
  1643
  7820.68
  Nabeel Ahmed
  3052 Orchard Drive
  San Jose
  CA
  95134
  Common Stock
  01/08/2024
  10709
  58792.41
  Shares sold to cover tax withholding obligations in connection with the vesting of Performance Stock Units. This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.
  01/16/2024
  John Brottem POA for Nabeel Ahmed