content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001388406</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001815442</issuerCik>
  <issuerName>KYMERA THERAPEUTICS, INC.</issuerName>
  <secFileNumber>001-39460</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">500 North Beacon Street</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">4th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Watertown</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02472</zipCode>
  </issuerAddress>
  <issuerContactPhone>(857)-285-5300</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Chadwick Jeremy G</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Smith Barney LLC</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">38th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>2575</noOfUnitsSold>
  <aggregateMarketValue>77688</aggregateMarketValue>
  <noOfUnitsOutstanding>65119568</noOfUnitsOutstanding>
  <approxSaleDate>05/23/2025</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>05/22/2025</acquiredDate>
  <natureOfAcquisitionTransaction>Shares acquired upon vesting of Restricted Stock Units awarded under the Issuer's 2020 Equity Incentive Plan.</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>KYMERA THERAPEUTICS, INC.</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2575</amountOfSecuritiesAcquired>
  <paymentDate>05/22/2025</paymentDate>
  <natureOfPayment>Equity compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Jeremy Chadwick</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">500 North Beacon Street</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">4th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Watertown</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02472</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>03/03/2025</saleDate>
  <amountOfSecuritiesSold>1383</amountOfSecuritiesSold>
  <grossProceeds>42097</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>The sales reported on this Form 144 represent shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of RSUs. These sales were automatic and intended to qualify under Rule 10b5-1.</remarks>
  <noticeSignature>
  <noticeDate>05/23/2025</noticeDate>
  <signature>/s/ Jeremy Chadwick</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3869}]
text: 144
  0001388406
  XXXXXXXX
  LIVE
  0001815442
  KYMERA THERAPEUTICS, INC.
  001-39460
  500 North Beacon Street
  4th Floor
  Watertown
  MA
  02472
  (857)-285-5300
  Chadwick Jeremy G
  Officer
  Common Stock
  Morgan Stanley Smith Barney LLC
  1 New York Plaza
  38th Floor
  New York
  NY
  10004
  2575
  77688
  65119568
  05/23/2025
  NASDAQ
  Common Stock
  05/22/2025
  Shares acquired upon vesting of Restricted Stock Units awarded under the Issuer's 2020 Equity Incentive Plan.
  KYMERA THERAPEUTICS, INC.
  N
  2575
  05/22/2025
  Equity compensation
  N
  Jeremy Chadwick
  500 North Beacon Street
  4th Floor
  Watertown
  MA
  02472
  Common Stock
  03/03/2025
  1383
  42097
  The sales reported on this Form 144 represent shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of RSUs. These sales were automatic and intended to qualify under Rule 10b5-1.
  05/23/2025
  /s/ Jeremy Chadwick