content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001863644</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001804591</issuerCik>
        <issuerName>23andMe Holding Co.</issuerName>
        <secFileNumber>001-39587</secFileNumber>
        <issuerAddress>
          <com:street1>349 Oyster Point Blvd</com:street1>
          <com:city>South San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>650-938-3600</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sequoia Grove UK LP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3615</noOfUnitsSold>
        <aggregateMarketValue>13809.3</aggregateMarketValue>
        <noOfUnitsOutstanding>19011874</noOfUnitsOutstanding>
        <approxSaleDate>11/15/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <acquiredDate>06/17/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Merger - Business Combination - see remarks</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3615</amountOfSecuritiesAcquired>
        <paymentDate>06/17/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Shares were purchased in a series of private financings.  new shares issued when company went public via a De Spac transaction.</remarks>
      <noticeSignature>
        <noticeDate>11/15/2024</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Sequoia Grove UK LP</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
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text: 144
  0001863644
  XXXXXXXX
  LIVE
  0001804591
  23andMe Holding Co.
  001-39587
  349 Oyster Point Blvd
  South San Francisco
  CA
  94080
  650-938-3600
  Sequoia Grove UK LP
  Affiliate
  Class A Common
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  3615
  13809.3
  19011874
  11/15/2024
  Nasdaq
  Class A Common
  06/17/2021
  Merger - Business Combination - see remarks
  Issuer
  N
  3615
  06/17/2021
  N/A
  Y
  Shares were purchased in a series of private financings.  new shares issued when company went public via a De Spac transaction.
  11/15/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Sequoia Grove UK LP