content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001263805</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
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      <issuerInfo>
        <issuerCik>0001631574</issuerCik>
        <issuerName>Wave Life Sciences Ltd.</issuerName>
        <secFileNumber>001-37627</secFileNumber>
        <issuerAddress>
          <com:street1>7 STRAITS VIEW, #12-00</com:street1>
          <com:street2>MARINA ONE EAST TOWER</com:street2>
          <com:city>Sinapore</com:city>
          <com:stateOrCountry>U0</com:stateOrCountry>
          <com:zipCode>01893</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-949-2900</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Christian Henry</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>10500</noOfUnitsSold>
        <aggregateMarketValue>102579</aggregateMarketValue>
        <noOfUnitsOutstanding>153486021</noOfUnitsOutstanding>
        <approxSaleDate>03/20/2025</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/20/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>10500</amountOfSecuritiesAcquired>
        <paymentDate>03/20/2025</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>03/20/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>11/24/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for  Christian Henry.</signature>
      </noticeSignature>
    </formData>
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text: 144
  0001263805
  XXXXXXXX
  LIVE
  0001631574
  Wave Life Sciences Ltd.
  001-37627
  7 STRAITS VIEW, #12-00
  MARINA ONE EAST TOWER
  Sinapore
  U0
  01893
  617-949-2900
  Christian Henry
  Director
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  10500
  102579
  153486021
  03/20/2025
  Nasdaq
  Common
  03/20/2025
  Stock Option Exercise
  Issuer
  N
  10500
  03/20/2025
  Cash
  Y
  03/20/2025
  11/24/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for  Christian Henry.