content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
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  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001553352</cik>
  <ccc>XXXXXXXX</ccc>
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  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
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  <formData>
  <issuerInfo>
  <issuerCik>0001719714</issuerCik>
  <issuerName>Mereo BioPharma Group plc</issuerName>
  <secFileNumber>001-38452</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">4th Floor, One Cavendish Place</street1>
  <city xmlns="http://www.sec.gov/edgar/common">London</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">X0</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">W1G 0QF</zipCode>
  </issuerAddress>
  <issuerContactPhone>44-333 023 7300</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Lewicki John A.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>American Depositary Shares Representing Ordinary Shares</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley International, plc</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">20 Bank Street</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Canary Wharf</street2>
  <city xmlns="http://www.sec.gov/edgar/common">London</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">X0</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">E14 4AD</zipCode>
  </address>
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  <noOfUnitsSold>26647</noOfUnitsSold>
  <aggregateMarketValue>106055.06</aggregateMarketValue>
  <noOfUnitsOutstanding>765150254</noOfUnitsOutstanding>
  <approxSaleDate>06/21/2024</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>American Depositary Shares Representing Ordinary Shares</securitiesClassTitle>
  <acquiredDate>06/21/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Same Day Cashless Exercise and Sale</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>69000</amountOfSecuritiesAcquired>
  <paymentDate>06/21/2024</paymentDate>
  <natureOfPayment>Equity Compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>The number of shares to be sold is in the form of American Depositary Shares ("ADSs"). The number of shares outstanding is in the form of ordinary shares. Each ADS represents 5 ordinary shares, nominal value GBP 0.003 per ordinary share, of the Issuer. Represents ADSs sold to cover tax obligations from vesting of Performance Based Restricted Share Units.</remarks>
  <noticeSignature>
  <noticeDate>06/20/2024</noticeDate>
  <signature>/s/ John A. Lewicki</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
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text: 144
  0001553352
  XXXXXXXX
  LIVE
  0001719714
  Mereo BioPharma Group plc
  001-38452
  4th Floor, One Cavendish Place
  London
  X0
  W1G 0QF
  44-333 023 7300
  Lewicki John A.
  Officer
  American Depositary Shares Representing Ordinary Shares
  Morgan Stanley International, plc
  20 Bank Street
  Canary Wharf
  London
  X0
  E14 4AD
  26647
  106055.06
  765150254
  06/21/2024
  Nasdaq
  American Depositary Shares Representing Ordinary Shares
  06/21/2024
  Same Day Cashless Exercise and Sale
  Issuer
  N
  69000
  06/21/2024
  Equity Compensation
  Y
  The number of shares to be sold is in the form of American Depositary Shares ("ADSs"). The number of shares outstanding is in the form of ordinary shares. Each ADS represents 5 ordinary shares, nominal value GBP 0.003 per ordinary share, of the Issuer. Represents ADSs sold to cover tax obligations from vesting of Performance Based Restricted Share Units.
  06/20/2024
  /s/ John A. Lewicki