content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001821198</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001815442</issuerCik>
  <issuerName>KYMERA THERAPEUTICS, INC.</issuerName>
  <secFileNumber>001-39460</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">200 ARSENAL YARDS BLVD.</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">SUITE 230</street2>
  <city xmlns="http://www.sec.gov/edgar/common">WATERTOWN</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02472</zipCode>
  </issuerAddress>
  <issuerContactPhone>857-285-5314</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Gollob Jared</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Smith Barney LLC</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">38th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>3344</noOfUnitsSold>
  <aggregateMarketValue>145464</aggregateMarketValue>
  <noOfUnitsOutstanding>61111678</noOfUnitsOutstanding>
  <approxSaleDate>03/04/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/01/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Shares acquired upon vesting of Restricted Stock Units awarded under the Issuer's 2020 Equity Incentive Plan.</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>KYMERA THERAPEUTICS, INC.</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>3344</amountOfSecuritiesAcquired>
  <paymentDate>03/01/2024</paymentDate>
  <natureOfPayment>Equity compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>10b5-1 Sales for JARED AUGUST GOLLOB</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">200 Arsenal Yards Blvd</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 230</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Watertown</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02472</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>COMMON</securitiesClassTitle>
  <saleDate>02/27/2024</saleDate>
  <amountOfSecuritiesSold>400</amountOfSecuritiesSold>
  <grossProceeds>18000.00</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>10b5-1 Sales for JARED AUGUST GOLLOB</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">200 Arsenal Yards Blvd</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite 230</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Watertown</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02472</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>COMMON</securitiesClassTitle>
  <saleDate>02/09/2024</saleDate>
  <amountOfSecuritiesSold>46137</amountOfSecuritiesSold>
  <grossProceeds>1638071.01</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>The sales reported on this Form 144 represent shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of RSUs. These sales were automatic and intended to qualify under Rule 10b5-1.</remarks>
  <noticeSignature>
  <noticeDate>03/04/2024</noticeDate>
  <signature>/s/ Jared Gollob</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4577}]
text: 144
  0001821198
  XXXXXXXX
  LIVE
  0001815442
  KYMERA THERAPEUTICS, INC.
  001-39460
  200 ARSENAL YARDS BLVD.
  SUITE 230
  WATERTOWN
  MA
  02472
  857-285-5314
  Gollob Jared
  Officer
  Common Stock
  Morgan Stanley Smith Barney LLC
  1 New York Plaza
  38th Floor
  New York
  NY
  10004
  3344
  145464
  61111678
  03/04/2024
  NASDAQ
  Common Stock
  03/01/2024
  Shares acquired upon vesting of Restricted Stock Units awarded under the Issuer's 2020 Equity Incentive Plan.
  KYMERA THERAPEUTICS, INC.
  N
  3344
  03/01/2024
  Equity compensation
  N
  10b5-1 Sales for JARED AUGUST GOLLOB
  200 Arsenal Yards Blvd
  Suite 230
  Watertown
  MA
  02472
  COMMON
  02/27/2024
  400
  18000.00
  10b5-1 Sales for JARED AUGUST GOLLOB
  200 Arsenal Yards Blvd
  Suite 230
  Watertown
  MA
  02472
  COMMON
  02/09/2024
  46137
  1638071.01
  The sales reported on this Form 144 represent shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of RSUs. These sales were automatic and intended to qualify under Rule 10b5-1.
  03/04/2024
  /s/ Jared Gollob