content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
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  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001826361</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
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  <issuerInfo>
  <issuerCik>0001582313</issuerCik>
  <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
  <secFileNumber>001-36687</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">200-3650 Gilmore Way</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Burnaby</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A1</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V5G 4W8</zipCode>
  </issuerAddress>
  <issuerContactPhone>(604)-484-3300</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ELIZABETH GAROFALO</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Wealth Management Canada Inc.</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">Suite 1500, 600 - 3 Avenue SW</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Calgary</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">Z4</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">T2P 0G5</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>2092</noOfUnitsSold>
  <aggregateMarketValue>95574</aggregateMarketValue>
  <noOfUnitsOutstanding>75432482</noOfUnitsOutstanding>
  <approxSaleDate>03/08/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <acquiredDate>03/08/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Exercise of Options</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2092</amountOfSecuritiesAcquired>
  <paymentDate>03/08/2024</paymentDate>
  <natureOfPayment>Net Exercise</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>03/08/2024</noticeDate>
  <signature>/s/ Elizabeth Garofalo</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2702}]
text: 144
  0001826361
  XXXXXXXX
  LIVE
  0001582313
  Xenon Pharmaceuticals Inc.
  001-36687
  200-3650 Gilmore Way
  Burnaby
  A1
  V5G 4W8
  (604)-484-3300
  ELIZABETH GAROFALO
  Director
  Common Shares
  Morgan Stanley Wealth Management Canada Inc.
  Suite 1500, 600 - 3 Avenue SW
  Calgary
  Z4
  T2P 0G5
  2092
  95574
  75432482
  03/08/2024
  NASDAQ
  Common Shares
  03/08/2024
  Exercise of Options
  Issuer
  N
  2092
  03/08/2024
  Net Exercise
  Y
  03/08/2024
  /s/ Elizabeth Garofalo