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  <secFileNumber>001-39509</secFileNumber>
  <issuerAddress>
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  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
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  <issuerContactPhone>781-786-8230</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Richard Scalzo</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
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  <relationshipToIssuer>SVP, Head of Finance &amp; Admin.</relationshipToIssuer>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>E*Trade Financial Corporation</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 Edison Drive</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Alpharaetta</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
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  <noOfUnitsSold>40000</noOfUnitsSold>
  <aggregateMarketValue>515425.00</aggregateMarketValue>
  <noOfUnitsOutstanding>58310703</noOfUnitsOutstanding>
  <approxSaleDate>06/13/2023</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>06/13/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Stock option exercise</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>40000</amountOfSecuritiesAcquired>
  <paymentDate>06/13/2023</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
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  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>03/14/2023</saleDate>
  <amountOfSecuritiesSold>1311</amountOfSecuritiesSold>
  <grossProceeds>17476.00</grossProceeds>
  </securitiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>06/13/2023</noticeDate>
  <signature>/s/ Richard Scalzo</signature>
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text: 144
  0001789545
  XXXXXXXX
  LIVE
  0001818794
  Dyne Therapeutics, Inc.
  001-39509
  1560 Trapelo Road
  Waltham
  MA
  02451
  781-786-8230
  Richard Scalzo
  SVP, Head of Finance & Admin.
  Common Stock
  E*Trade Financial Corporation
  3 Edison Drive
  Alpharaetta
  GA
  30005
  40000
  515425.00
  58310703
  06/13/2023
  NASDAQ
  Common Stock
  06/13/2023
  Stock option exercise
  Issuer
  N
  40000
  06/13/2023
  Cash
  N
  Richard Scalzo
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  03/14/2023
  1311
  17476.00
  06/13/2023
  /s/ Richard Scalzo