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  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
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  <issuerContactPhone>(781)-786-8230</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jonathan McNeill</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
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  <city xmlns="http://www.sec.gov/edgar/common">Alpharaetta</city>
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  <zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
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  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
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  <amountOfSecuritiesAcquired>2434</amountOfSecuritiesAcquired>
  <paymentDate>02/15/2024</paymentDate>
  <natureOfPayment>Equity compensation</natureOfPayment>
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  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
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  <amountOfSecuritiesSold>1245</amountOfSecuritiesSold>
  <grossProceeds>13346</grossProceeds>
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  <sellerDetails>
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  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>01/02/2024</saleDate>
  <amountOfSecuritiesSold>11900</amountOfSecuritiesSold>
  <grossProceeds>155890</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Jonathan McNeill</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>01/03/2024</saleDate>
  <amountOfSecuritiesSold>17991</amountOfSecuritiesSold>
  <grossProceeds>337048</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Jonathan McNeill</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>01/04/2024</saleDate>
  <amountOfSecuritiesSold>2009</amountOfSecuritiesSold>
  <grossProceeds>36246</grossProceeds>
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  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Jonathan McNeill</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>01/26/2024</saleDate>
  <amountOfSecuritiesSold>20000</amountOfSecuritiesSold>
  <grossProceeds>490502</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Jonathan McNeill</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>02/29/2024</saleDate>
  <amountOfSecuritiesSold>4268</amountOfSecuritiesSold>
  <grossProceeds>117382</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Jonathan McNeill</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
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  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>03/01/2024</saleDate>
  <amountOfSecuritiesSold>24260</amountOfSecuritiesSold>
  <grossProceeds>694497</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>Sale represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on November 15, 2023.</remarks>
  <noticeSignature>
  <noticeDate>03/07/2024</noticeDate>
  <signature>/s/ Richard Scalzo, Attorney-in-Fact</signature>
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text: 144
  0001824673
  XXXXXXXX
  LIVE
  0001818794
  Dyne Therapeutics, Inc.
  001-39509
  1560 Trapelo Road
  Waltham
  MA
  02451
  (781)-786-8230
  Jonathan McNeill
  Officer
  Common Stock
  E*Trade Financial Corporation
  3 Edison Drive
  Alpharaetta
  GA
  30005
  2434
  62921
  81958068
  03/07/2024
  NASDAQ
  Common Stock
  02/15/2024
  Shares acquired upon vesting of restricted stock units granted pursuant to issuer's 2020 stock incentive plan
  Issuer
  N
  2434
  02/15/2024
  Equity compensation
  N
  Jonathan McNeill
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  12/11/2023
  1245
  13346
  Jonathan McNeill
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  01/02/2024
  11900
  155890
  Jonathan McNeill
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  01/03/2024
  17991
  337048
  Jonathan McNeill
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  01/04/2024
  2009
  36246
  Jonathan McNeill
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  01/26/2024
  20000
  490502
  Jonathan McNeill
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  02/29/2024
  4268
  117382
  Jonathan McNeill
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  03/01/2024
  24260
  694497
  Sale represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on November 15, 2023.
  03/07/2024
  /s/ Richard Scalzo, Attorney-in-Fact