content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
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  <submissionType>144</submissionType>
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  <filer>
  <filerCredentials>
  <cik>0001270734</cik>
  <ccc>XXXXXXXX</ccc>
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  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
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  <issuerInfo>
  <issuerCik>0001719714</issuerCik>
  <issuerName>Mereo BioPharma Group plc</issuerName>
  <secFileNumber>001-38452</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">4th Floor, One Cavendish Place</street1>
  <city xmlns="http://www.sec.gov/edgar/common">London</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">X0</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">W1G 0QF</zipCode>
  </issuerAddress>
  <issuerContactPhone>44-333 023 7300</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Deepika Pakianathan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>American Depositary Shares Representing Ordinary Shares</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">8th Floor</street2>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>105244</noOfUnitsSold>
  <aggregateMarketValue>466209.87</aggregateMarketValue>
  <noOfUnitsOutstanding>769262609</noOfUnitsOutstanding>
  <approxSaleDate>08/22/2024</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>American Depositary Shares Representing Ordinary Shares</securitiesClassTitle>
  <acquiredDate>08/22/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Exercise of option under a registered plan</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>105244</amountOfSecuritiesAcquired>
  <paymentDate>08/22/2024</paymentDate>
  <natureOfPayment>Services Rendered</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <remarks>Shares to be sold are American Depositary Shares ("ADSs"). The number of shares outstanding are ordinary shares. Each ADS represents five ordinary shares. Sale is due to fund administration reasons.</remarks>
  <noticeSignature>
  <noticeDate>08/22/2024</noticeDate>
  <signature>/s/ Deepika Pakianathan</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
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text: 144
  0001270734
  XXXXXXXX
  LIVE
  0001719714
  Mereo BioPharma Group plc
  001-38452
  4th Floor, One Cavendish Place
  London
  X0
  W1G 0QF
  44-333 023 7300
  Deepika Pakianathan
  Director
  American Depositary Shares Representing Ordinary Shares
  Morgan Stanley Smith Barney LLC Executive Financial Services
  1 New York Plaza
  8th Floor
  New York
  NY
  10004
  105244
  466209.87
  769262609
  08/22/2024
  Nasdaq
  American Depositary Shares Representing Ordinary Shares
  08/22/2024
  Exercise of option under a registered plan
  Issuer
  N
  105244
  08/22/2024
  Services Rendered
  Y
  Shares to be sold are American Depositary Shares ("ADSs"). The number of shares outstanding are ordinary shares. Each ADS represents five ordinary shares. Sale is due to fund administration reasons.
  08/22/2024
  /s/ Deepika Pakianathan