content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001883139</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001818331</issuerCik>
        <issuerName>GeneDx Holdings Corp.</issuerName>
        <secFileNumber>001-39482</secFileNumber>
        <issuerAddress>
          <com:street1>333 LUDLOW STREET</com:street1>
          <com:street2>NORTH TOWER, 6TH FLOOR</com:street2>
          <com:city>STAMFORD</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>888 729 1206</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Jefferies LLC</name>
          <address>
            <com:street1>520 Madison Avenue</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10022</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1012941</noOfUnitsSold>
        <aggregateMarketValue>82747150.29</aggregateMarketValue>
        <noOfUnitsOutstanding>27471397</noOfUnitsOutstanding>
        <approxSaleDate>10/31/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <acquiredDate>01/31/2023</acquiredDate>
        <natureOfAcquisitionTransaction>Purchase from Issuer</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>865800</amountOfSecuritiesAcquired>
        <paymentDate>01/31/2023</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <acquiredDate>04/29/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Purchase from Issuer</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>147141</amountOfSecuritiesAcquired>
        <paymentDate>04/29/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>Share amounts have been adjusted to reflect a 1-for-33 reverse stock split of the Issuer's common stock that became effective on May 4, 2023.</remarks>
      <noticeSignature>
        <noticeDate>10/31/2024</noticeDate>
        <signature>/s/ Vincent Tammaro, Chief Financial Officer</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3549}]
text: 144
  0001883139
  XXXXXXXX
  LIVE
  0001818331
  GeneDx Holdings Corp.
  001-39482
  333 LUDLOW STREET
  NORTH TOWER, 6TH FLOOR
  STAMFORD
  CT
  06902
  888 729 1206
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  10% Stockholder
  Class A Common Stock
  Jefferies LLC
  520 Madison Avenue
  New York
  NY
  10022
  1012941
  82747150.29
  27471397
  10/31/2024
  NASDAQ
  Class A Common Stock
  01/31/2023
  Purchase from Issuer
  Issuer
  N
  865800
  01/31/2023
  Cash
  Class A Common Stock
  04/29/2022
  Purchase from Issuer
  Issuer
  N
  147141
  04/29/2022
  Cash
  Y
  Share amounts have been adjusted to reflect a 1-for-33 reverse stock split of the Issuer's common stock that became effective on May 4, 2023.
  10/31/2024
  /s/ Vincent Tammaro, Chief Financial Officer