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            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerCik>0001818331</issuerCik>
        <issuerName>GeneDx Holdings Corp.</issuerName>
        <secFileNumber>001-39482</secFileNumber>
        <issuerAddress>
          <com:street1>333 LUDLOW STREET</com:street1>
          <com:street2>NORTH TOWER, 8TH FLOOR</com:street2>
          <com:city>STAMFORD</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617 780 8742</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Stockholder</relationshipToIssuer>
        </relationshipsToIssuer>
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      <securitiesInformation>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Jefferies LLC</name>
          <address>
            <com:street1>520 Madison Avenue</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10022</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1346123</noOfUnitsSold>
        <aggregateMarketValue>104809136.78</aggregateMarketValue>
        <noOfUnitsOutstanding>27471397</noOfUnitsOutstanding>
        <approxSaleDate>01/30/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesInformation>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>TD Cowen &amp; Co</name>
          <address>
            <com:street1>599 Lexington Ave</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10022</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1346123</noOfUnitsSold>
        <aggregateMarketValue>104809136.78</aggregateMarketValue>
        <noOfUnitsOutstanding>27471397</noOfUnitsOutstanding>
        <approxSaleDate>01/30/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <acquiredDate>07/22/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Merger Consideration</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2677439</amountOfSecuritiesAcquired>
        <paymentDate>07/22/2021</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <acquiredDate>04/29/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Purchase from Issuer</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>42253</amountOfSecuritiesAcquired>
        <paymentDate>04/29/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI</name>
          <address>
            <com:street1>150 East 42nd Street, Suite 2-B.17</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <saleDate>10/31/2024</saleDate>
        <amountOfSecuritiesSold>865800</amountOfSecuritiesSold>
        <grossProceeds>64935000.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI</name>
          <address>
            <com:street1>150 East 42nd Street, Suite 2-B.17</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <saleDate>11/15/2024</saleDate>
        <amountOfSecuritiesSold>20359</amountOfSecuritiesSold>
        <grossProceeds>1420663.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI</name>
          <address>
            <com:street1>150 East 42nd Street, Suite 2-B.17</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
        <saleDate>11/18/2024</saleDate>
        <amountOfSecuritiesSold>126782</amountOfSecuritiesSold>
        <grossProceeds>8973059.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>Share amounts have been adjusted to reflect a 1-for-33 reverse stock split of the Issuer's common stock that became effective on May 4, 2023. It is intended that the 1,346,123 shares will be offered through the two brokers listed, though the allocation among such brokers has not yet been definitively determined. The shares are intended to be sold from time to time beginning 1/30/2025.</remarks>
      <noticeSignature>
        <noticeDate>01/30/2025</noticeDate>
        <signature>/s/ Vincent Tammaro, Chief Financial Officer</signature>
      </noticeSignature>
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text: 144
  0001883139
  XXXXXXXX
  LIVE
  0001818331
  GeneDx Holdings Corp.
  001-39482
  333 LUDLOW STREET
  NORTH TOWER, 8TH FLOOR
  STAMFORD
  CT
  06902
  617 780 8742
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  Stockholder
  Class A Common Stock
  Jefferies LLC
  520 Madison Avenue
  New York
  NY
  10022
  1346123
  104809136.78
  27471397
  01/30/2025
  NASDAQ
  Class A Common Stock
  TD Cowen & Co
  599 Lexington Ave
  New York
  NY
  10022
  1346123
  104809136.78
  27471397
  01/30/2025
  NASDAQ
  Class A Common Stock
  07/22/2021
  Merger Consideration
  Issuer
  N
  2677439
  07/22/2021
  N/A
  Class A Common Stock
  04/29/2022
  Purchase from Issuer
  Issuer
  N
  42253
  04/29/2022
  Cash
  N
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street, Suite 2-B.17
  New York
  NY
  10017
  Class A Common Stock
  10/31/2024
  865800
  64935000.00
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street, Suite 2-B.17
  New York
  NY
  10017
  Class A Common Stock
  11/15/2024
  20359
  1420663.00
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street, Suite 2-B.17
  New York
  NY
  10017
  Class A Common Stock
  11/18/2024
  126782
  8973059.00
  Share amounts have been adjusted to reflect a 1-for-33 reverse stock split of the Issuer's common stock that became effective on May 4, 2023. It is intended that the 1,346,123 shares will be offered through the two brokers listed, though the allocation among such brokers has not yet been definitively determined. The shares are intended to be sold from time to time beginning 1/30/2025.
  01/30/2025
  /s/ Vincent Tammaro, Chief Financial Officer