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        <issuerAddress>
          <com:street1>545 FIFTH AVENUE, SUITE 1400</com:street1>
          <com:city>NEW YORK</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>212-220-9226</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Shendelman Shoshana</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>President and Chief Executive Officer</relationshipToIssuer>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
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          <address>
            <com:street1>200 West Street</com:street1>
            <com:street2>39th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10282</com:zipCode>
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        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>1000000</noOfUnitsSold>
        <aggregateMarketValue>6210000.00</aggregateMarketValue>
        <noOfUnitsOutstanding>114846271</noOfUnitsOutstanding>
        <approxSaleDate>08/12/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>01/21/2016</acquiredDate>
        <natureOfAcquisitionTransaction>Private transaction with Issuer</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>1000000</amountOfSecuritiesAcquired>
        <paymentDate>01/21/2016</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>08/09/2024</noticeDate>
        <signature>/s/ Shoshana Shendelman</signature>
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text: 144
  0001775490
  XXXXXXXX
  LIVE
  0001697532
  Applied Therapeutics, Inc.
  001-38898
  545 FIFTH AVENUE, SUITE 1400
  NEW YORK
  NY
  10017
  212-220-9226
  Shendelman Shoshana
  Officer
  President and Chief Executive Officer
  Common Stock
  Goldman, Sachs & Co. LLC
  200 West Street
  39th Floor
  New York
  NY
  10282
  1000000
  6210000.00
  114846271
  08/12/2024
  NASDAQ
  Common Stock
  01/21/2016
  Private transaction with Issuer
  Issuer
  N
  1000000
  01/21/2016
  Cash
  Y
  08/09/2024
  /s/ Shoshana Shendelman