content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001691005</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001818794</issuerCik>
  <issuerName>Dyne Therapeutics, Inc.</issuerName>
  <secFileNumber>001-39509</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </issuerAddress>
  <issuerContactPhone>(781)-786-8230</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Susanna High</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>E*Trade Financial Corporation</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 Edison Drive</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Alpharaetta</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>1616</noOfUnitsSold>
  <aggregateMarketValue>17328</aggregateMarketValue>
  <noOfUnitsOutstanding>61375598</noOfUnitsOutstanding>
  <approxSaleDate>12/11/2023</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>12/10/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>1616</amountOfSecuritiesAcquired>
  <paymentDate>12/10/2023</paymentDate>
  <natureOfPayment>N/A</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Susanna High</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>09/12/2023</saleDate>
  <amountOfSecuritiesSold>1635</amountOfSecuritiesSold>
  <grossProceeds>17020</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Susanna High</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>09/18/2023</saleDate>
  <amountOfSecuritiesSold>2672</amountOfSecuritiesSold>
  <grossProceeds>25144</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Susanna High</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1560 Trapelo Road</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Waltham</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02451</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>11/02/2023</saleDate>
  <amountOfSecuritiesSold>9939</amountOfSecuritiesSold>
  <grossProceeds>73513</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>Sale represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on December 10, 2021 and December 9, 2022.</remarks>
  <noticeSignature>
  <noticeDate>12/11/2023</noticeDate>
  <signature>/s/ Richard Scalzo, Attorney-in-Fact</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4812}]
text: 144
  0001691005
  XXXXXXXX
  LIVE
  0001818794
  Dyne Therapeutics, Inc.
  001-39509
  1560 Trapelo Road
  Waltham
  MA
  02451
  (781)-786-8230
  Susanna High
  Officer
  Common Stock
  E*Trade Financial Corporation
  3 Edison Drive
  Alpharaetta
  GA
  30005
  1616
  17328
  61375598
  12/11/2023
  NASDAQ
  Common Stock
  12/10/2023
  Restricted stock units granted pursuant to Issuer's 2020 Stock Incentive Plan, subject to vesting requirements
  Issuer
  N
  1616
  12/10/2023
  N/A
  N
  Susanna High
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  09/12/2023
  1635
  17020
  Susanna High
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  09/18/2023
  2672
  25144
  Susanna High
  1560 Trapelo Road
  Waltham
  MA
  02451
  Common Stock
  11/02/2023
  9939
  73513
  Sale represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on December 10, 2021 and December 9, 2022.
  12/11/2023
  /s/ Richard Scalzo, Attorney-in-Fact