content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001983850</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001727196</issuerCik>
        <issuerName>Scholar Rock Holding Corp.</issuerName>
        <secFileNumber>001-38501</secFileNumber>
        <issuerAddress>
          <com:street1>301 Binney Street, 3rd Floor</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>857-259-3860</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Katie Peng</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>4037</noOfUnitsSold>
        <aggregateMarketValue>139680</aggregateMarketValue>
        <noOfUnitsOutstanding>94676763</noOfUnitsOutstanding>
        <approxSaleDate>03/17/2025</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/15/2025</acquiredDate>
        <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>261</amountOfSecuritiesAcquired>
        <paymentDate>02/15/2025</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/15/2025</acquiredDate>
        <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>745</amountOfSecuritiesAcquired>
        <paymentDate>03/15/2025</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>03/15/2025</acquiredDate>
        <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>3031</amountOfSecuritiesAcquired>
        <paymentDate>03/15/2025</paymentDate>
        <natureOfPayment>NA</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>This Form 144 covers sales of vested shares over a three month period from 2/15/2025 - 6/15/2025</remarks>
      <noticeSignature>
        <noticeDate>03/17/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>11/20/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Katie Peng</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4072}]
text: 144
  0001983850
  XXXXXXXX
  LIVE
  0001727196
  Scholar Rock Holding Corp.
  001-38501
  301 Binney Street, 3rd Floor
  Cambridge
  MA
  02142
  857-259-3860
  Katie Peng
  Director
  Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  4037
  139680
  94676763
  03/17/2025
  Nasdaq
  Common
  02/15/2025
  RSU
  Issuer
  N
  261
  02/15/2025
  NA
  Common
  03/15/2025
  RSU
  Issuer
  N
  745
  03/15/2025
  NA
  Common
  03/15/2025
  RSU
  Issuer
  N
  3031
  03/15/2025
  NA
  Y
  This Form 144 covers sales of vested shares over a three month period from 2/15/2025 - 6/15/2025
  03/17/2025
  11/20/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Katie Peng