content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001620084</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001582313</issuerCik>
  <issuerName>Xenon Pharmaceuticals Inc.</issuerName>
  <secFileNumber>001-36687</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">200-3650 Gilmore Way</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Burnaby</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A1</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V5G 4W8</zipCode>
  </issuerAddress>
  <issuerContactPhone>(604)-484-3300</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SIMON PIMSTONE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley Wealth Management Canada Inc.</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">Suite 1500, 600 - 3 Avenue SW</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Calgary</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A0</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">T2P 0G5</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>31713</noOfUnitsSold>
  <aggregateMarketValue>1225707</aggregateMarketValue>
  <noOfUnitsOutstanding>63562303</noOfUnitsOutstanding>
  <approxSaleDate>06/01/2023</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <acquiredDate>06/01/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Exercise of Options</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>31713</amountOfSecuritiesAcquired>
  <paymentDate>06/01/2023</paymentDate>
  <natureOfPayment>Net Exercise</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>RBC Dominion Securities</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1055 West Georgia Street, 32nd Floor</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Vancouver</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A1</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V6E 3P3</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <saleDate>05/31/2023</saleDate>
  <amountOfSecuritiesSold>12000</amountOfSecuritiesSold>
  <grossProceeds>462400</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Morgan Stanley Wealth Management Canada Inc.</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">Suite 1500, 600-3 Avenue SW</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Calgary</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A0</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">T2P 0G5</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <saleDate>05/31/2023</saleDate>
  <amountOfSecuritiesSold>50526</amountOfSecuritiesSold>
  <grossProceeds>1957737</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>RBC Dominion Securities</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1055 West Georgia Street, 32nd Floor</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Vancouver</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A1</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">V6E 3P3</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <saleDate>05/30/2023</saleDate>
  <amountOfSecuritiesSold>37006</amountOfSecuritiesSold>
  <grossProceeds>1453651</grossProceeds>
  </securitiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Morgan Stanley Wealth Management Canada Inc.</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">Suite 1500, 600-3 Avenue SW</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Calgary</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">A0</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">T2P 0G5</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Shares</securitiesClassTitle>
  <saleDate>03/07/2023</saleDate>
  <amountOfSecuritiesSold>19232</amountOfSecuritiesSold>
  <grossProceeds>711184</grossProceeds>
  </securitiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>06/01/2023</noticeDate>
  <signature>Simon Pimstone</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5268}]
text: 144
  0001620084
  XXXXXXXX
  LIVE
  0001582313
  Xenon Pharmaceuticals Inc.
  001-36687
  200-3650 Gilmore Way
  Burnaby
  A1
  V5G 4W8
  (604)-484-3300
  SIMON PIMSTONE
  Director
  Common Shares
  Morgan Stanley Wealth Management Canada Inc.
  Suite 1500, 600 - 3 Avenue SW
  Calgary
  A0
  T2P 0G5
  31713
  1225707
  63562303
  06/01/2023
  NASDAQ
  Common Shares
  06/01/2023
  Exercise of Options
  Issuer
  N
  31713
  06/01/2023
  Net Exercise
  N
  RBC Dominion Securities
  1055 West Georgia Street, 32nd Floor
  Vancouver
  A1
  V6E 3P3
  Common Shares
  05/31/2023
  12000
  462400
  Morgan Stanley Wealth Management Canada Inc.
  Suite 1500, 600-3 Avenue SW
  Calgary
  A0
  T2P 0G5
  Common Shares
  05/31/2023
  50526
  1957737
  RBC Dominion Securities
  1055 West Georgia Street, 32nd Floor
  Vancouver
  A1
  V6E 3P3
  Common Shares
  05/30/2023
  37006
  1453651
  Morgan Stanley Wealth Management Canada Inc.
  Suite 1500, 600-3 Avenue SW
  Calgary
  A0
  T2P 0G5
  Common Shares
  03/07/2023
  19232
  711184
  06/01/2023
  Simon Pimstone