content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <!-- Field: Pseudo-Tag; ID: Name; Data: ORBIMED ADVISORS LLC -->
            <cik>0001055951</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001800315</issuerCik>
        <issuerName>Galecto</issuerName>
        <secFileNumber>001-39655</secFileNumber>
        <issuerAddress>
          <com:street1>75 State Street</com:street1>
          <com:street2>Suite 100</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02109</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>45-70-70-52-10</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>OrbiMed Private Investments VII, LP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Shareholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Themis Trading LLC</name>
          <address>
            <com:street1>10 Town Square</com:street1>
            <com:street2>Suite 100</com:street2>
            <com:city>Chatham</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07928</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>22638</noOfUnitsSold>
        <aggregateMarketValue>43012.20</aggregateMarketValue>
        <noOfUnitsOutstanding>25673474</noOfUnitsOutstanding>
        <approxSaleDate>04/10/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq Stock Market</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>09/25/2020</acquiredDate>
        <natureOfAcquisitionTransaction>Private placement</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>22638</amountOfSecuritiesAcquired>
        <paymentDate>09/25/2020</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>OrbiMed Private Investments VII, LP</name>
          <address>
            <com:street1>601 Lexington Ave.</com:street1>
            <com:street2>54th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10022</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>04/05/2023</saleDate>
        <amountOfSecuritiesSold>63058</amountOfSecuritiesSold>
        <grossProceeds>137466.44</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>OrbiMed Capital GP VII LLC is the general partner of OrbiMed Private Investments VII, LP. OrbiMed Advisors LLC is the managing member of OrbiMed Capital GP VII LLC. Additional sales made on April 6, 2023. OrbiMed Private Investments VII, LP sold 6,558 shares of Common Stock for gross proceeds of $13,116.</remarks>
      <noticeSignature>
        <noticeDate>04/10/2023</noticeDate>
        <signature>/s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors LLC, managing member of the general partner of OrbiMed Private Investments VII, LP</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4002}]
text: 144
  0001055951
  XXXXXXXX
  LIVE
  0001800315
  Galecto
  001-39655
  75 State Street
  Suite 100
  Boston
  MA
  02109
  45-70-70-52-10
  OrbiMed Private Investments VII, LP
  Shareholder
  Common Stock
  Themis Trading LLC
  10 Town Square
  Suite 100
  Chatham
  NJ
  07928
  22638
  43012.20
  25673474
  04/10/2023
  Nasdaq Stock Market
  Common Stock
  09/25/2020
  Private placement
  Issuer
  N
  22638
  09/25/2020
  Cash
  N
  OrbiMed Private Investments VII, LP
  601 Lexington Ave.
  54th Floor
  New York
  NY
  10022
  Common Stock
  04/05/2023
  63058
  137466.44
  OrbiMed Capital GP VII LLC is the general partner of OrbiMed Private Investments VII, LP. OrbiMed Advisors LLC is the managing member of OrbiMed Capital GP VII LLC. Additional sales made on April 6, 2023. OrbiMed Private Investments VII, LP sold 6,558 shares of Common Stock for gross proceeds of $13,116.
  04/10/2023
  /s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors LLC, managing member of the general partner of OrbiMed Private Investments VII, LP