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          <filerCredentials>
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            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <issuerAddress>
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          <com:street2>DUBLIN 2 L2 D02 T380</com:street2>
          <com:city>Dublin</com:city>
          <com:stateOrCountry>L2</com:stateOrCountry>
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        <issuerContactPhone>353-1-905-8020</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Vicki Goodman</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
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          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
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        <noOfUnitsSold>13186</noOfUnitsSold>
        <aggregateMarketValue>53271</aggregateMarketValue>
        <noOfUnitsOutstanding>17060310</noOfUnitsOutstanding>
        <approxSaleDate>02/24/2025</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>13186</amountOfSecuritiesAcquired>
        <paymentDate>11/06/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>02/24/2025</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Vicki Goodman.</signature>
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text: 144
  0001901477
  XXXXXXXX
  LIVE
  0001971543
  Mural Oncology  plc
  001-41837
  10 EARLSFORT TERRACE
  DUBLIN 2 L2 D02 T380
  Dublin
  L2
  T380
  353-1-905-8020
  Vicki Goodman
  Officer
  Ordinary Shares
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  13186
  53271
  17060310
  02/24/2025
  Nasdaq
  Ordinary Shares
  11/06/2024
  RSU Vest
  Issuer
  N
  13186
  11/06/2024
  Compensation
  Y
  02/24/2025
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Vicki Goodman.