content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001671311</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001724521</issuerCik>
  <issuerName>Arcus Biosciences, Inc.</issuerName>
  <secFileNumber>001-38419</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">3928 Point Eden Way</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Hayward</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">94545</zipCode>
  </issuerAddress>
  <issuerContactPhone>(510)-694-6200</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jennifer Jarrett</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>COMMON</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>E*TRADE FINANCIAL CORPORATION</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 EDISON DRIVE</street1>
  <city xmlns="http://www.sec.gov/edgar/common">ALPHARETTA</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>13500</noOfUnitsSold>
  <aggregateMarketValue>270000</aggregateMarketValue>
  <noOfUnitsOutstanding>73105580</noOfUnitsOutstanding>
  <approxSaleDate>06/16/2023</approxSaleDate>
  <securitiesExchangeName>NYSE</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>COMMON</securitiesClassTitle>
  <acquiredDate>06/15/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Vesting of restricted stock granted 1/19/2021</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Arcus Biosciences, Inc.</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>25000</amountOfSecuritiesAcquired>
  <paymentDate>06/15/2023</paymentDate>
  <natureOfPayment>Services rendered</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>E*TRADE FINANCIAL CORPORATION</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 EDISON DRIVE</street1>
  <city xmlns="http://www.sec.gov/edgar/common">ALPHARETTA</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
  <saleDate>03/16/2023</saleDate>
  <amountOfSecuritiesSold>8729</amountOfSecuritiesSold>
  <grossProceeds>146729.36</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>The reported transactions represent mandatory sell-to-cover transactions effected pursuant to the Issuer's equity administration policy.</remarks>
  <noticeSignature>
  <noticeDate>06/15/2023</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>01/15/2021</planAdoptionDate>
  </planAdoptionDates>
  <signature>/s/ Jennifer Jarrett</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3618}]
text: 144
  0001671311
  XXXXXXXX
  LIVE
  0001724521
  Arcus Biosciences, Inc.
  001-38419
  3928 Point Eden Way
  Hayward
  CA
  94545
  (510)-694-6200
  Jennifer Jarrett
  Officer
  Director
  COMMON
  E*TRADE FINANCIAL CORPORATION
  3 EDISON DRIVE
  ALPHARETTA
  GA
  30005
  13500
  270000
  73105580
  06/16/2023
  NYSE
  COMMON
  06/15/2023
  Vesting of restricted stock granted 1/19/2021
  Arcus Biosciences, Inc.
  N
  25000
  06/15/2023
  Services rendered
  N
  E*TRADE FINANCIAL CORPORATION
  3 EDISON DRIVE
  ALPHARETTA
  GA
  30005
  COMMON STOCK
  03/16/2023
  8729
  146729.36
  The reported transactions represent mandatory sell-to-cover transactions effected pursuant to the Issuer's equity administration policy.
  06/15/2023
  01/15/2021
  /s/ Jennifer Jarrett