content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
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  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001816414</cik>
  <ccc>XXXXXXXX</ccc>
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  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
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  <formData>
  <issuerInfo>
  <issuerCik>0000318154</issuerCik>
  <issuerName>Amgen Inc.</issuerName>
  <secFileNumber>001-37702</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">One Amgen Center Drive</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Thousand Oaks</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">91320</zipCode>
  </issuerAddress>
  <issuerContactPhone>805-447-1603</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Nancy A. Grygiel</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Raymond James &amp; Associates, Inc.</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">880 Carillon Parkway</street1>
  <city xmlns="http://www.sec.gov/edgar/common">St. Petersburg</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">FL</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">33716</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>2117</noOfUnitsSold>
  <aggregateMarketValue>657132.91</aggregateMarketValue>
  <noOfUnitsOutstanding>536434692</noOfUnitsOutstanding>
  <approxSaleDate>05/03/2024</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/19/2021</acquiredDate>
  <natureOfAcquisitionTransaction>Performance Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>820</amountOfSecuritiesAcquired>
  <paymentDate>03/19/2021</paymentDate>
  <natureOfPayment>Equity compensation</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/18/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Performance Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>659</amountOfSecuritiesAcquired>
  <paymentDate>03/18/2022</paymentDate>
  <natureOfPayment>Equity compensation</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>03/17/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Performance Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>638</amountOfSecuritiesAcquired>
  <paymentDate>03/17/2023</paymentDate>
  <natureOfPayment>Equity compensation</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>05/03/2024</noticeDate>
  <signature>/s/ Nancy A. Grygiel</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
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text: 144
  0001816414
  XXXXXXXX
  LIVE
  0000318154
  Amgen Inc.
  001-37702
  One Amgen Center Drive
  Thousand Oaks
  CA
  91320
  805-447-1603
  Nancy A. Grygiel
  Officer
  Common Stock
  Raymond James & Associates, Inc.
  880 Carillon Parkway
  St. Petersburg
  FL
  33716
  2117
  657132.91
  536434692
  05/03/2024
  Nasdaq
  Common Stock
  03/19/2021
  Performance Units
  Issuer
  N
  820
  03/19/2021
  Equity compensation
  Common Stock
  03/18/2022
  Performance Units
  Issuer
  N
  659
  03/18/2022
  Equity compensation
  Common Stock
  03/17/2023
  Performance Units
  Issuer
  N
  638
  03/17/2023
  Equity compensation
  Y
  05/03/2024
  /s/ Nancy A. Grygiel