content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001786351</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001773427</issuerCik>
  <issuerName>SpringWorks Therapeutics, Inc.</issuerName>
  <secFileNumber>001-39044</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">100 Washington Blvd.</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Stamford</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">CT</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">06902</zipCode>
  </issuerAddress>
  <issuerContactPhone>203-883-9490</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BC SW, LP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Former Affiliate</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Goldman Sachs &amp; Co. LLC</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">200 West Street</street1>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10282</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>500000</noOfUnitsSold>
  <aggregateMarketValue>11955000</aggregateMarketValue>
  <noOfUnitsOutstanding>62578877</noOfUnitsOutstanding>
  <approxSaleDate>11/02/2023</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/17/2019</acquiredDate>
  <natureOfAcquisitionTransaction>Automatic conversion of convertible preferred stock purchased prior to the Issuer's IPO into shares of the Issuer's Common Stock</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>7131307</amountOfSecuritiesAcquired>
  <paymentDate>09/17/2019</paymentDate>
  <natureOfPayment>Automatic conversion of preferred stock</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>09/17/2019</acquiredDate>
  <natureOfAcquisitionTransaction>Purchase of Common Stock in an underwritten public offering</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Underwriter</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>150000</amountOfSecuritiesAcquired>
  <paymentDate>09/17/2019</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>11/02/2023</noticeDate>
  <signature>/s/ Jeffrey Schwartz, as Partner of Bain Capital Life Sciences Investors, LLC</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3389}]
text: 144
  0001786351
  XXXXXXXX
  LIVE
  0001773427
  SpringWorks Therapeutics, Inc.
  001-39044
  100 Washington Blvd.
  Stamford
  CT
  06902
  203-883-9490
  BC SW, LP
  Former Affiliate
  Common Stock
  Goldman Sachs & Co. LLC
  200 West Street
  New York
  NY
  10282
  500000
  11955000
  62578877
  11/02/2023
  Nasdaq
  Common Stock
  09/17/2019
  Automatic conversion of convertible preferred stock purchased prior to the Issuer's IPO into shares of the Issuer's Common Stock
  Issuer
  N
  7131307
  09/17/2019
  Automatic conversion of preferred stock
  Common Stock
  09/17/2019
  Purchase of Common Stock in an underwritten public offering
  Underwriter
  N
  150000
  09/17/2019
  Cash
  Y
  11/02/2023
  /s/ Jeffrey Schwartz, as Partner of Bain Capital Life Sciences Investors, LLC