content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0001915257</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001937653</issuerCik>
  <issuerName>Zymeworks Inc.</issuerName>
  <secFileNumber>001-41535</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">108 Patriot Drive</street1>
  <street2 xmlns="http://www.sec.gov/edgar/common">Suite A</street2>
  <city xmlns="http://www.sec.gov/edgar/common">Middletown</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">DE</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">19709</zipCode>
  </issuerAddress>
  <issuerContactPhone>302-274-8744</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Christopher Astle</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Former Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1585 Broadway</street1>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10036</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>86294</noOfUnitsSold>
  <aggregateMarketValue>774057.18</aggregateMarketValue>
  <noOfUnitsOutstanding>70704890</noOfUnitsOutstanding>
  <approxSaleDate>06/11/2024</approxSaleDate>
  <securitiesExchangeName>Nasdaq</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>01/07/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Purchased pursuant to Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>670</amountOfSecuritiesAcquired>
  <paymentDate>01/07/2022</paymentDate>
  <natureOfPayment>Cash payment pursuant to Employee Stock Purchase Plan</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>12/12/2022</acquiredDate>
  <natureOfAcquisitionTransaction>Acquired as compensation - Restricted Stock Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>663</amountOfSecuritiesAcquired>
  <paymentDate>12/12/2022</paymentDate>
  <natureOfPayment>Compensation</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>12/11/2023</acquiredDate>
  <natureOfAcquisitionTransaction>Acquired as compensation - Restricted Stock Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>664</amountOfSecuritiesAcquired>
  <paymentDate>12/11/2023</paymentDate>
  <natureOfPayment>Compensation</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>01/05/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Acquired as compensation - Restricted Stock Units</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>4506</amountOfSecuritiesAcquired>
  <paymentDate>01/05/2024</paymentDate>
  <natureOfPayment>Compensation</natureOfPayment>
  </securitiesToBeSold>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>06/11/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Exercise of options</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>79791</amountOfSecuritiesAcquired>
  <paymentDate>06/11/2024</paymentDate>
  <natureOfPayment>Exercise and sell to cover</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>06/11/2024</noticeDate>
  <signature>/s/ Christopher Astle</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4819}]
text: 144
  0001915257
  XXXXXXXX
  LIVE
  0001937653
  Zymeworks Inc.
  001-41535
  108 Patriot Drive
  Suite A
  Middletown
  DE
  19709
  302-274-8744
  Christopher Astle
  Former Officer
  Common Stock
  Morgan Stanley
  1585 Broadway
  New York
  NY
  10036
  86294
  774057.18
  70704890
  06/11/2024
  Nasdaq
  Common Stock
  01/07/2022
  Purchased pursuant to Employee Stock Purchase Plan
  Issuer
  N
  670
  01/07/2022
  Cash payment pursuant to Employee Stock Purchase Plan
  Common Stock
  12/12/2022
  Acquired as compensation - Restricted Stock Units
  Issuer
  N
  663
  12/12/2022
  Compensation
  Common Stock
  12/11/2023
  Acquired as compensation - Restricted Stock Units
  Issuer
  N
  664
  12/11/2023
  Compensation
  Common Stock
  01/05/2024
  Acquired as compensation - Restricted Stock Units
  Issuer
  N
  4506
  01/05/2024
  Compensation
  Common Stock
  06/11/2024
  Exercise of options
  Issuer
  N
  79791
  06/11/2024
  Exercise and sell to cover
  Y
  06/11/2024
  /s/ Christopher Astle