content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
  <submissionType>144</submissionType>
  <filerInfo>
  <filer>
  <filerCredentials>
  <cik>0002033155</cik>
  <ccc>XXXXXXXX</ccc>
  </filerCredentials>
  </filer>
  <liveTestFlag>LIVE</liveTestFlag>
  </filerInfo>
  </headerData>
  <formData>
  <issuerInfo>
  <issuerCik>0001745999</issuerCik>
  <issuerName>BEAM THERAPEUTICS INC.</issuerName>
  <secFileNumber>001-39208</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">238 Main Street</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Cambridge</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02142</zipCode>
  </issuerAddress>
  <issuerContactPhone>857-327-8775</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold> BETHANY J. CAVANAGH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  </relationshipsToIssuer>
  </issuerInfo>
  <securitiesInformation>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>ETRADE FINANCIAL CORPORATION</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">3 EDISON DRIVE</street1>
  <city xmlns="http://www.sec.gov/edgar/common">ALPHARETTA</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
  </address>
  </brokerOrMarketmakerDetails>
  <noOfUnitsSold>9500</noOfUnitsSold>
  <aggregateMarketValue>240065</aggregateMarketValue>
  <noOfUnitsOutstanding>82805627</noOfUnitsOutstanding>
  <approxSaleDate>12/31/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
  </securitiesInformation>
  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <acquiredDate>12/31/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>9500</amountOfSecuritiesAcquired>
  <paymentDate>12/31/2024</paymentDate>
  <natureOfPayment>Services Rendered</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <securitiesSoldInPast3Months>
  <sellerDetails>
  <name>Bethany Cavanagh</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">238 Main Street</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Cambridge</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02142</zipCode>
  </address>
  </sellerDetails>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
  <saleDate>10/01/2024</saleDate>
  <amountOfSecuritiesSold>289</amountOfSecuritiesSold>
  <grossProceeds>6785.46</grossProceeds>
  </securitiesSoldInPast3Months>
  <remarks>Securities to be sold represent shares of common stock sold in a non-discretionary transaction by the seller in order to cover tax withholding obligations upon the vesting of certain restricted stock units granted to the seller.</remarks>
  <noticeSignature>
  <noticeDate>12/30/2024</noticeDate>
  <planAdoptionDates>
  <planAdoptionDate>02/27/2023</planAdoptionDate>
  </planAdoptionDates>
  <signature>/s/Bethany J. Cavanagh</signature>
  </noticeSignature>
  </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3614}]
text: 144
  0002033155
  XXXXXXXX
  LIVE
  0001745999
  BEAM THERAPEUTICS INC.
  001-39208
  238 Main Street
  Cambridge
  MA
  02142
  857-327-8775
  BETHANY J. CAVANAGH
  Officer
  Common Stock
  ETRADE FINANCIAL CORPORATION
  3 EDISON DRIVE
  ALPHARETTA
  GA
  30005
  9500
  240065
  82805627
  12/31/2024
  NASDAQ
  Common Stock
  12/31/2024
  Restricted Stock Vesting
  Issuer
  N
  9500
  12/31/2024
  Services Rendered
  N
  Bethany Cavanagh
  238 Main Street
  Cambridge
  MA
  02142
  Common Stock
  10/01/2024
  289
  6785.46
  Securities to be sold represent shares of common stock sold in a non-discretionary transaction by the seller in order to cover tax withholding obligations upon the vesting of certain restricted stock units granted to the seller.
  12/30/2024
  02/27/2023
  /s/Bethany J. Cavanagh