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        <secFileNumber>001-41740</secFileNumber>
        <issuerAddress>
          <com:street1>221 CRESCENT ST.</com:street1>
          <com:street2>BUILDING 17, SUITE 102B</com:street2>
          <com:city>WALTHAM</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02453</com:zipCode>
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        <issuerContactPhone>650-394-5230</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>HENDERSON MICHAEL THOMAS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
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      <securitiesInformation>
        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>RBC CAPITAL MARKETS LLC </name>
          <address>
            <com:street1>250 NICOLLET MALL</com:street1>
            <com:street2>SUITE 1700</com:street2>
            <com:city>MINNEAPOLIS</com:city>
            <com:stateOrCountry>MN</com:stateOrCountry>
            <com:zipCode>55401</com:zipCode>
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        <noOfUnitsSold>15000</noOfUnitsSold>
        <aggregateMarketValue>558915.00</aggregateMarketValue>
        <noOfUnitsOutstanding>58546027</noOfUnitsOutstanding>
        <approxSaleDate>07/05/2024</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <securitiesClassTitle>COMMON</securitiesClassTitle>
        <acquiredDate>05/22/2022</acquiredDate>
        <natureOfAcquisitionTransaction>STOCK OPTION EXERCISE </natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>15000</amountOfSecuritiesAcquired>
        <paymentDate>05/22/2022</paymentDate>
        <natureOfPayment>CHECK</natureOfPayment>
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      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>SHARES SOLD PURSUANT TO A RULE 10B5-1 SELLING PLAN ESTABLISHED SEPTEMBER 25, 2023</remarks>
      <noticeSignature>
        <noticeDate>07/05/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>09/25/2023</planAdoptionDate>
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        <signature>JEFFREY J KAPALA</signature>
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text: 144
  0001779990
  XXXXXXXX
  LIVE
  0001974640
  Apogee Therapeutics, Inc.
  001-41740
  221 CRESCENT ST.
  BUILDING 17, SUITE 102B
  WALTHAM
  MA
  02453
  650-394-5230
  HENDERSON MICHAEL THOMAS
  Officer
  Director
  COMMON
  RBC CAPITAL MARKETS LLC
  250 NICOLLET MALL
  SUITE 1700
  MINNEAPOLIS
  MN
  55401
  15000
  558915.00
  58546027
  07/05/2024
  NASDAQ
  COMMON
  05/22/2022
  STOCK OPTION EXERCISE
  ISSUER
  N
  15000
  05/22/2022
  CHECK
  Y
  SHARES SOLD PURSUANT TO A RULE 10B5-1 SELLING PLAN ESTABLISHED SEPTEMBER 25, 2023
  07/05/2024
  09/25/2023
  JEFFREY J KAPALA