content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001995659</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001785279</issuerCik>
        <issuerName>Metagenomi, Inc.</issuerName>
        <secFileNumber>001-41949</secFileNumber>
        <issuerAddress>
          <com:street1>5959 Horton Street, 7th Floor</com:street1>
          <com:city>Emeryville</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94608</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>510-871-4880</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sebastian Bernales</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue - 6th Floor</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>769845</noOfUnitsSold>
        <aggregateMarketValue>1470404</aggregateMarketValue>
        <noOfUnitsOutstanding>37381495</noOfUnitsOutstanding>
        <approxSaleDate>07/09/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>01/24/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Conversion of Common Units</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>256841</amountOfSecuritiesAcquired>
        <paymentDate>01/24/2024</paymentDate>
        <natureOfPayment>Exchange of Assets</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>02/13/2024</acquiredDate>
        <natureOfAcquisitionTransaction>Conversion of Preferred Stock</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>513004</amountOfSecuritiesAcquired>
        <paymentDate>02/13/2024</paymentDate>
        <natureOfPayment>Exchange of Assets</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>07/09/2025</noticeDate>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Sebastian Bernales</signature>
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text: 144
  0001995659
  XXXXXXXX
  LIVE
  0001785279
  Metagenomi, Inc.
  001-41949
  5959 Horton Street, 7th Floor
  Emeryville
  CA
  94608
  510-871-4880
  Sebastian Bernales
  Affiliate
  Common Stock
  J.P. Morgan Securities LLC
  390 Madison Avenue - 6th Floor
  New York
  NY
  10017
  769845
  1470404
  37381495
  07/09/2025
  NASDAQ
  Common Stock
  01/24/2024
  Conversion of Common Units
  Issuer
  N
  256841
  01/24/2024
  Exchange of Assets
  Common Stock
  02/13/2024
  Conversion of Preferred Stock
  Issuer
  N
  513004
  02/13/2024
  Exchange of Assets
  Y
  07/09/2025
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Sebastian Bernales