content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <!-- Field: Pseudo-Tag; ID: Name; Data: ORBIMED ADVISORS LLC -->
            <cik>0001055951</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
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      <issuerInfo>
        <issuerCik>0001816736</issuerCik>
        <issuerName>Disc Medicine, Inc.</issuerName>
        <secFileNumber>001-39438</secFileNumber>
        <issuerAddress>
          <com:street1>321 Arsenal Street, Suite 101</com:street1>
          <com:city>Watertown</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02472</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>617-674-9274</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>OrbiMed Private Investments VIII, LP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Shareholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Themis Trading LLC</name>
          <address>
            <com:street1>10 Townsquare</com:street1>
            <com:city>Chatham</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07928</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>487360</noOfUnitsSold>
        <aggregateMarketValue>29748454.00</aggregateMarketValue>
        <noOfUnitsOutstanding>24140428</noOfUnitsOutstanding>
        <approxSaleDate>12/12/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq Stock Market</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>12/29/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Business Combination</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>487360</amountOfSecuritiesAcquired>
        <paymentDate>12/29/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <remarks>OrbiMed Capital GP VIII LLC is the general partner of OrbiMed Private Investments VIII, LP. OrbiMed Advisors LLC is the managing member of OrbiMed Capital GP VIII LLC.</remarks>
      <noticeSignature>
        <noticeDate>12/12/2023</noticeDate>
        <signature>/s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors LLC, managing member of the general partner of OrbiMed Private Investments VIII, LP</signature>
      </noticeSignature>
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text: 144
  0001055951
  XXXXXXXX
  LIVE
  0001816736
  Disc Medicine, Inc.
  001-39438
  321 Arsenal Street, Suite 101
  Watertown
  MA
  02472
  617-674-9274
  OrbiMed Private Investments VIII, LP
  Shareholder
  Common Stock
  Themis Trading LLC
  10 Townsquare
  Chatham
  NJ
  07928
  487360
  29748454.00
  24140428
  12/12/2023
  Nasdaq Stock Market
  Common Stock
  12/29/2022
  Business Combination
  Issuer
  N
  487360
  12/29/2022
  Cash
  Y
  OrbiMed Capital GP VIII LLC is the general partner of OrbiMed Private Investments VIII, LP. OrbiMed Advisors LLC is the managing member of OrbiMed Capital GP VIII LLC.
  12/12/2023
  /s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors LLC, managing member of the general partner of OrbiMed Private Investments VIII, LP