content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001677950</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0000318154</issuerCik>
        <issuerName>AMGEN INC</issuerName>
        <secFileNumber>001-37702</secFileNumber>
        <issuerAddress>
          <com:street1>ONE AMGEN CENTER DRIVE</com:street1>
          <com:city>THOUSAND OAKS</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91320</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>(805)447-1000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Santos Esteban</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Affiliate</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Pershing Advisor Solutions</name>
          <address>
            <com:street1>One Pershing Plaza 4th Floor</com:street1>
            <com:city>Jersey City</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07399</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>8711</noOfUnitsSold>
        <aggregateMarketValue>2544570.21</aggregateMarketValue>
        <noOfUnitsOutstanding>57367</noOfUnitsOutstanding>
        <approxSaleDate>02/19/2025</approxSaleDate>
        <securitiesExchangeName>NASDAQ</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <acquiredDate>02/18/2025</acquiredDate>
        <natureOfAcquisitionTransaction>Equity Compensation 2016 Stock Option Grant</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>8711</amountOfSecuritiesAcquired>
        <paymentDate>02/18/2025</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <noticeSignature>
        <noticeDate>02/19/2025</noticeDate>
        <signature>Esteban Santos</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 2733}]
text: 144
  0001677950
  XXXXXXXX
  LIVE
  0000318154
  AMGEN INC
  001-37702
  ONE AMGEN CENTER DRIVE
  THOUSAND OAKS
  CA
  91320
  (805)447-1000
  Santos Esteban
  Affiliate
  Common
  Pershing Advisor Solutions
  One Pershing Plaza 4th Floor
  Jersey City
  NJ
  07399
  8711
  2544570.21
  57367
  02/19/2025
  NASDAQ
  Common
  02/18/2025
  Equity Compensation 2016 Stock Option Grant
  Issuer
  N
  8711
  02/18/2025
  Cash
  Y
  02/19/2025
  Esteban Santos