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            <com:zipCode>10017</com:zipCode>
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            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
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            <com:zipCode>10017</com:zipCode>
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      <noticeSignature>
        <noticeDate>02/24/2025</noticeDate>
        <signature>/s/ Vincent Tammaro, Chief Financial Officer</signature>
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text: 144
  0001883139
  XXXXXXXX
  LIVE
  0001818331
  GeneDx Holdings Corp.
  001-39482
  333 LUDLOW STREET
  NORTH TOWER, 6TH FLOOR
  STAMFORD
  CT
  06902
  888-729-1206
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  Stockholder
  Class A Common Stock
  Jefferies LLC
  520 Madison Avenue
  New York
  NY
  10022
  373569
  35799117.27
  28068274
  02/24/2025
  NASDAQ
  Class A Common Stock
  TD Cowen & Co
  599 Lexington Ave
  New York
  NY
  10022
  373569
  35799117.27
  28068274
  02/24/2025
  NASDAQ
  Class A Common Stock
  07/22/2021
  Merger Consideration
  Issuer
  N
  2677439
  07/22/2021
  N/A
  N
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street
  Suite 2- B.1
  New York
  NY
  10017
  Class A Common Stock
  11/15/2024
  20359
  1420663.00
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street
  Suite 2- B.17
  New York
  NY
  10017
  Class A Common Stock
  11/18/2024
  126782
  8973059.00
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street
  Suite 2- B.17
  New York
  NY
  10017
  Class A Common Stock
  01/30/2025
  200000
  15700000.00
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street
  Suite 2- B.17
  New York
  NY
  10017
  Class A Common Stock
  02/13/2025
  400000
  31031040.00
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street
  Suite 2- B.17
  New York
  NY
  10017
  Class A Common Stock
  02/14/2025
  89676
  6898739.00
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street
  Suite 2- B.17
  New York
  NY
  10017
  Class A Common Stock
  02/18/2025
  350000
  35142415.00
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street
  Suite 2- B.17
  New York
  NY
  10017
  Class A Common Stock
  02/19/2025
  100000
  10857230.00
  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  150 East 42nd Street
  Suite 2- B.17
  New York
  NY
  10017
  Class A Common Stock
  02/20/2025
  206447
  20854140.00
  Share amounts have been adjusted to reflect a 1-for-33 reverse stock split of the Issuer's common stock that became effective on May 4, 2023. It is intended that the 373,569 shares will be offered through the two brokers listed, though the allocation among such brokers has not yet been definitively determined. The shares are intended to be sold from time to time beginning 02/24/2025.
  02/24/2025
  /s/ Vincent Tammaro, Chief Financial Officer