content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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      <filerInfo>
        <filer>
          <filerCredentials>
            <!-- Field: Pseudo-Tag; ID: Name; Data: OrbiMed Advisors Israel II Ltd -->
            <cik>0001682093</cik>
            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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      <issuerInfo>
        <issuerCik>0001800315</issuerCik>
        <issuerName>Galecto, Inc.</issuerName>
        <secFileNumber>001-39655</secFileNumber>
        <issuerAddress>
          <com:street1>75 State Street</com:street1>
          <com:street2>Suite 100</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02109</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>45-70-70-52-10</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>OrbiMed Israel Partners II, L.P.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Shareholder</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Bank of America</name>
          <address>
            <com:street1>One Bryant Park</com:street1>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10036</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>489970</noOfUnitsSold>
        <aggregateMarketValue>367478.00</aggregateMarketValue>
        <noOfUnitsOutstanding>25673474</noOfUnitsOutstanding>
        <approxSaleDate>08/15/2023</approxSaleDate>
        <securitiesExchangeName>Nasdaq Stock Market</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>10/23/2018</acquiredDate>
        <natureOfAcquisitionTransaction>Private placement</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>489970</amountOfSecuritiesAcquired>
        <paymentDate>10/23/2018</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>OrbiMed Israel Partners II, L.P.</name>
          <address>
            <com:street1>5 Hahoshlim St.</com:street1>
            <com:street2>Building B, 1st Floor</com:street2>
            <com:city>Herzliya Pituach</com:city>
            <com:stateOrCountry>L3</com:stateOrCountry>
            <com:zipCode>4672405</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>07/13/2023</saleDate>
        <amountOfSecuritiesSold>52800</amountOfSecuritiesSold>
        <grossProceeds>126720.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>OrbiMed Israel Partners II, L.P.</name>
          <address>
            <com:street1>5 Hahoshlim St.</com:street1>
            <com:street2>Building B, 1st Floor</com:street2>
            <com:city>Herzliya Pituach</com:city>
            <com:stateOrCountry>L3</com:stateOrCountry>
            <com:zipCode>4672405</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>07/25/2023</saleDate>
        <amountOfSecuritiesSold>4700</amountOfSecuritiesSold>
        <grossProceeds>13724.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>OrbiMed Israel Partners II, L.P.</name>
          <address>
            <com:street1>5 Hahoshlim St.</com:street1>
            <com:street2>Building B, 1st Floor</com:street2>
            <com:city>Herzliya Pituach</com:city>
            <com:stateOrCountry>L3</com:stateOrCountry>
            <com:zipCode>4672405</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>07/31/2023</saleDate>
        <amountOfSecuritiesSold>29700</amountOfSecuritiesSold>
        <grossProceeds>89100.00</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>OrbiMed Israel GP II, L.P. is the general partner of OrbiMed Israel Partners II, L.P. OrbiMed Advisors Israel II Limited is the general partner of OrbiMed Israel GP II, L.P.</remarks>
      <noticeSignature>
        <noticeDate>08/15/2023</noticeDate>
        <signature>/s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors II Limited, general partner of the general partner of OrbiMed Israel Partners II, L.P.</signature>
      </noticeSignature>
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text: 144
  0001682093
  XXXXXXXX
  LIVE
  0001800315
  Galecto, Inc.
  001-39655
  75 State Street
  Suite 100
  Boston
  MA
  02109
  45-70-70-52-10
  OrbiMed Israel Partners II, L.P.
  Shareholder
  Common Stock
  Bank of America
  One Bryant Park
  New York
  NY
  10036
  489970
  367478.00
  25673474
  08/15/2023
  Nasdaq Stock Market
  Common Stock
  10/23/2018
  Private placement
  Issuer
  N
  489970
  10/23/2018
  Cash
  N
  OrbiMed Israel Partners II, L.P.
  5 Hahoshlim St.
  Building B, 1st Floor
  Herzliya Pituach
  L3
  4672405
  Common Stock
  07/13/2023
  52800
  126720.00
  OrbiMed Israel Partners II, L.P.
  5 Hahoshlim St.
  Building B, 1st Floor
  Herzliya Pituach
  L3
  4672405
  Common Stock
  07/25/2023
  4700
  13724.00
  OrbiMed Israel Partners II, L.P.
  5 Hahoshlim St.
  Building B, 1st Floor
  Herzliya Pituach
  L3
  4672405
  Common Stock
  07/31/2023
  29700
  89100.00
  OrbiMed Israel GP II, L.P. is the general partner of OrbiMed Israel Partners II, L.P. OrbiMed Advisors Israel II Limited is the general partner of OrbiMed Israel GP II, L.P.
  08/15/2023
  /s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors II Limited, general partner of the general partner of OrbiMed Israel Partners II, L.P.