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            <ccc>XXXXXXXX</ccc>
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        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
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        <secFileNumber>001-39231</secFileNumber>
        <issuerAddress>
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          <com:street2>2005 Market Street, 39th Floor</com:street2>
          <com:city>Philadelphia</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19103</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>2678660312</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>OrbiMed Private Investments VII, LP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Stockholder</relationshipToIssuer>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>Themis Trading LLC</name>
          <address>
            <com:street1>10 Town Square</com:street1>
            <com:street2>Suite 100</com:street2>
            <com:city>Chatham</com:city>
            <com:stateOrCountry>NJ</com:stateOrCountry>
            <com:zipCode>07928</com:zipCode>
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        <noOfUnitsSold>2985518</noOfUnitsSold>
        <aggregateMarketValue>2657111.02</aggregateMarketValue>
        <noOfUnitsOutstanding>61767286</noOfUnitsOutstanding>
        <approxSaleDate>12/04/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq Stock Market</securitiesExchangeName>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/03/2020</acquiredDate>
        <natureOfAcquisitionTransaction>IPO</natureOfAcquisitionTransaction>
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        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2985518</amountOfSecuritiesAcquired>
        <paymentDate>03/03/2020</paymentDate>
        <natureOfPayment>N/A</natureOfPayment>
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          <name>OrbiMed Private Investments VII, LP</name>
          <address>
            <com:street1>601 Lexington Ave.</com:street1>
            <com:street2>54th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10022</com:zipCode>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>09/16/2024</saleDate>
        <amountOfSecuritiesSold>63100</amountOfSecuritiesSold>
        <grossProceeds>46927.47</grossProceeds>
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          <name>OrbiMed Private Investments VII, LP</name>
          <address>
            <com:street1>601 Lexington Ave.</com:street1>
            <com:street2>54th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10022</com:zipCode>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>09/17/2024</saleDate>
        <amountOfSecuritiesSold>111400</amountOfSecuritiesSold>
        <grossProceeds>81728.61</grossProceeds>
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          <name>OrbiMed Private Investments VII, LP</name>
          <address>
            <com:street1>601 Lexington Ave.</com:street1>
            <com:street2>54th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10022</com:zipCode>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>09/18/2024</saleDate>
        <amountOfSecuritiesSold>25631</amountOfSecuritiesSold>
        <grossProceeds>18712.68</grossProceeds>
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      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>OrbiMed Private Investments VII, LP</name>
          <address>
            <com:street1>601 Lexington Ave.</com:street1>
            <com:street2>54th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10022</com:zipCode>
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        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <saleDate>09/19/2024</saleDate>
        <amountOfSecuritiesSold>39300</amountOfSecuritiesSold>
        <grossProceeds>27871.95</grossProceeds>
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      <remarks>OrbiMed Capital GP VII LLC is the general partner of OrbiMed Private Investments VII, LP. OrbiMed Advisors LLC is the managing member of OrbiMed Capital GP VII LLC.</remarks>
      <noticeSignature>
        <noticeDate>12/04/2024</noticeDate>
        <signature>/s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors LLC, managing member of the general partner of OrbiMed Private Investments VII, LP</signature>
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text: 144
  0001055951
  XXXXXXXX
  LIVE
  0001787297
  Passage BIO, Inc.
  001-39231
  One Commerce Square
  2005 Market Street, 39th Floor
  Philadelphia
  PA
  19103
  2678660312
  OrbiMed Private Investments VII, LP
  Stockholder
  Common Stock
  Themis Trading LLC
  10 Town Square
  Suite 100
  Chatham
  NJ
  07928
  2985518
  2657111.02
  61767286
  12/04/2024
  Nasdaq Stock Market
  Common Stock
  03/03/2020
  IPO
  Issuer
  N
  2985518
  03/03/2020
  N/A
  N
  OrbiMed Private Investments VII, LP
  601 Lexington Ave.
  54th Floor
  New York
  NY
  10022
  Common Stock
  09/16/2024
  63100
  46927.47
  OrbiMed Private Investments VII, LP
  601 Lexington Ave.
  54th Floor
  New York
  NY
  10022
  Common Stock
  09/17/2024
  111400
  81728.61
  OrbiMed Private Investments VII, LP
  601 Lexington Ave.
  54th Floor
  New York
  NY
  10022
  Common Stock
  09/18/2024
  25631
  18712.68
  OrbiMed Private Investments VII, LP
  601 Lexington Ave.
  54th Floor
  New York
  NY
  10022
  Common Stock
  09/19/2024
  39300
  27871.95
  OrbiMed Capital GP VII LLC is the general partner of OrbiMed Private Investments VII, LP. OrbiMed Advisors LLC is the managing member of OrbiMed Capital GP VII LLC.
  12/04/2024
  /s/ Douglas Coon, Chief Compliance Officer, OrbiMed Advisors LLC, managing member of the general partner of OrbiMed Private Investments VII, LP