content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
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  <issuerName>Mereo BioPharma Group plc</issuerName>
  <secFileNumber>001-38452</secFileNumber>
  <issuerAddress>
  <street1 xmlns="http://www.sec.gov/edgar/common">4th Floor, One Cavendish Place</street1>
  <city xmlns="http://www.sec.gov/edgar/common">London</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">X0</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">W1G 0QF</zipCode>
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  <issuerContactPhone>44-333 023 7300</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Scots-Knight Denise</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
  <relationshipsToIssuer>
  <relationshipToIssuer>Officer</relationshipToIssuer>
  <relationshipToIssuer>Director</relationshipToIssuer>
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  <securitiesInformation>
  <securitiesClassTitle>American Depositary Shares Representing Ordinary Shares</securitiesClassTitle>
  <brokerOrMarketmakerDetails>
  <name>Morgan Stanley &amp; Co. LLC</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1585 Broadway</street1>
  <city xmlns="http://www.sec.gov/edgar/common">New York</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">10036-8293</zipCode>
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  <noOfUnitsSold>88657</noOfUnitsSold>
  <aggregateMarketValue>413141.62</aggregateMarketValue>
  <noOfUnitsOutstanding>769262609</noOfUnitsOutstanding>
  <approxSaleDate>09/12/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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  <securitiesClassTitle>American Depositary Shares Representing Ordinary Shares</securitiesClassTitle>
  <acquiredDate>09/12/2024</acquiredDate>
  <natureOfAcquisitionTransaction>Same Day Cashless Exercise and Sale</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>188060</amountOfSecuritiesAcquired>
  <paymentDate>09/12/2024</paymentDate>
  <natureOfPayment>Equity Compensation</natureOfPayment>
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  <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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  <name>Denise Scots-Knight</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">4th Floor, One Cavendish Place</street1>
  <city xmlns="http://www.sec.gov/edgar/common">London</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">X0</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">W1G 0QF</zipCode>
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  <securitiesClassTitle>American Depositary Shares Representing Ordinary Shares</securitiesClassTitle>
  <saleDate>06/25/2024</saleDate>
  <amountOfSecuritiesSold>40712</amountOfSecuritiesSold>
  <grossProceeds>150386.06</grossProceeds>
  </securitiesSoldInPast3Months>
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  <name>Denise Scots-Knight</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">4th Floor, One Cavendish Place</street1>
  <city xmlns="http://www.sec.gov/edgar/common">London</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">X0</stateOrCountry>
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  <securitiesClassTitle>American Depositary Shares Representing Ordinary Shares</securitiesClassTitle>
  <saleDate>06/26/2024</saleDate>
  <amountOfSecuritiesSold>92273</amountOfSecuritiesSold>
  <grossProceeds>313100.74</grossProceeds>
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  <remarks>The number of shares to be sold is in the form of American Depositary Shares ("ADSs"). The number of shares outstanding is in the form of ordinary shares. Each ADS represents 5 ordinary shares, nominal value GBP 0.003 per ordinary share, of the Issuer. Represents ADSs sold to cover tax obligations from vesting of Performance Based Restricted Share Units.</remarks>
  <noticeSignature>
  <noticeDate>09/12/2024</noticeDate>
  <signature>/s/ Denise Scots-Knight</signature>
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text: 144
  0001297000
  XXXXXXXX
  LIVE
  0001719714
  Mereo BioPharma Group plc
  001-38452
  4th Floor, One Cavendish Place
  London
  X0
  W1G 0QF
  44-333 023 7300
  Scots-Knight Denise
  Officer
  Director
  American Depositary Shares Representing Ordinary Shares
  Morgan Stanley & Co. LLC
  1585 Broadway
  New York
  NY
  10036-8293
  88657
  413141.62
  769262609
  09/12/2024
  NASDAQ
  American Depositary Shares Representing Ordinary Shares
  09/12/2024
  Same Day Cashless Exercise and Sale
  Issuer
  N
  188060
  09/12/2024
  Equity Compensation
  N
  Denise Scots-Knight
  4th Floor, One Cavendish Place
  London
  X0
  W1G 0QF
  American Depositary Shares Representing Ordinary Shares
  06/25/2024
  40712
  150386.06
  Denise Scots-Knight
  4th Floor, One Cavendish Place
  London
  X0
  W1G 0QF
  American Depositary Shares Representing Ordinary Shares
  06/26/2024
  92273
  313100.74
  The number of shares to be sold is in the form of American Depositary Shares ("ADSs"). The number of shares outstanding is in the form of ordinary shares. Each ADS represents 5 ordinary shares, nominal value GBP 0.003 per ordinary share, of the Issuer. Represents ADSs sold to cover tax obligations from vesting of Performance Based Restricted Share Units.
  09/12/2024
  /s/ Denise Scots-Knight