content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001751980</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001321732</issuerCik>
        <issuerName>Penumbra, Inc.</issuerName>
        <secFileNumber>001-37557</secFileNumber>
        <issuerAddress>
          <com:street1>One Penumbra Place</com:street1>
          <com:city>Alameda</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94502</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>510-748-3200</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Johanna Roberts</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Officer</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>3000</noOfUnitsSold>
        <aggregateMarketValue>769890</aggregateMarketValue>
        <noOfUnitsOutstanding>38725940</noOfUnitsOutstanding>
        <approxSaleDate>07/01/2025</approxSaleDate>
        <securitiesExchangeName>NYSE</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>03/15/2024</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>196</amountOfSecuritiesAcquired>
        <paymentDate>03/15/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>04/15/2024</acquiredDate>
        <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>347</amountOfSecuritiesAcquired>
        <paymentDate>04/15/2024</paymentDate>
        <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
      <securitiesToBeSold>
        <securitiesClassTitle>Common Stock</securitiesClassTitle>
        <acquiredDate>12/28/2022</acquiredDate>
        <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>2457</amountOfSecuritiesAcquired>
        <paymentDate>12/28/2022</paymentDate>
        <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Johanna Roberts</name>
          <address>
            <com:street1>C/o Penumbra, Inc.</com:street1>
            <com:street2>One Penumbra Place</com:street2>
            <com:city>Alameda</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94502</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>04/24/2025</saleDate>
        <amountOfSecuritiesSold>600</amountOfSecuritiesSold>
        <grossProceeds>180008.84</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Johanna Roberts</name>
          <address>
            <com:street1>C/o Penumbra, Inc.</com:street1>
            <com:street2>One Penumbra Place</com:street2>
            <com:city>Alameda</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94502</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>05/12/2025</saleDate>
        <amountOfSecuritiesSold>900</amountOfSecuritiesSold>
        <grossProceeds>268699.32</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Johanna Roberts</name>
          <address>
            <com:street1>C/o Penumbra, Inc.</com:street1>
            <com:street2>One Penumbra Place</com:street2>
            <com:city>Alameda</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94502</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Common</securitiesClassTitle>
        <saleDate>06/02/2025</saleDate>
        <amountOfSecuritiesSold>600</amountOfSecuritiesSold>
        <grossProceeds>154903.44</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>The shares represented by this filing are expected to be sold within 3 months of this filing.</remarks>
      <noticeSignature>
        <noticeDate>07/01/2025</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>11/26/2024</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Johanna Roberts</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6040}]
text: 144
  0001751980
  XXXXXXXX
  LIVE
  0001321732
  Penumbra, Inc.
  001-37557
  One Penumbra Place
  Alameda
  CA
  94502
  510-748-3200
  Johanna Roberts
  Officer
  Common Stock
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  3000
  769890
  38725940
  07/01/2025
  NYSE
  Common Stock
  03/15/2024
  RSU Vesting
  Issuer
  N
  196
  03/15/2024
  Compensation
  Common Stock
  04/15/2024
  RSU Vesting
  Issuer
  N
  347
  04/15/2024
  Compensation
  Common Stock
  12/28/2022
  Option Exercise
  Issuer
  N
  2457
  12/28/2022
  Cash
  N
  Johanna Roberts
  C/o Penumbra, Inc.
  One Penumbra Place
  Alameda
  CA
  94502
  Common
  04/24/2025
  600
  180008.84
  Johanna Roberts
  C/o Penumbra, Inc.
  One Penumbra Place
  Alameda
  CA
  94502
  Common
  05/12/2025
  900
  268699.32
  Johanna Roberts
  C/o Penumbra, Inc.
  One Penumbra Place
  Alameda
  CA
  94502
  Common
  06/02/2025
  600
  154903.44
  The shares represented by this filing are expected to be sold within 3 months of this filing.
  07/01/2025
  11/26/2024
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Johanna Roberts