content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
    <!-- Generated by Workiva -->
    <headerData>
      <submissionType>144</submissionType>
      <filerInfo>
        <filer>
          <filerCredentials>
            <cik>0001862123</cik>
            <ccc>XXXXXXXX</ccc>
          </filerCredentials>
        </filer>
        <liveTestFlag>LIVE</liveTestFlag>
  
  
  
      </filerInfo>
    </headerData>
    <formData>
      <issuerInfo>
        <issuerCik>0001861560</issuerCik>
        <issuerName>Nuvalent Inc</issuerName>
        <secFileNumber>001-40671</secFileNumber>
        <issuerAddress>
          <com:street1>One Broadway, 14th Floor</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </issuerAddress>
        <issuerContactPhone>857-357-7000</issuerContactPhone>
        <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Matthew Shair</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
        <relationshipsToIssuer>
          <relationshipToIssuer>Director</relationshipToIssuer>
        </relationshipsToIssuer>
      </issuerInfo>
      <securitiesInformation>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <brokerOrMarketmakerDetails>
          <name>J.P. Morgan Securities LLC</name>
          <address>
            <com:street1>390 Madison Avenue</com:street1>
            <com:street2>6th Floor</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10017</com:zipCode>
          </address>
        </brokerOrMarketmakerDetails>
        <noOfUnitsSold>8000</noOfUnitsSold>
        <aggregateMarketValue>771600</aggregateMarketValue>
        <noOfUnitsOutstanding>65617305</noOfUnitsOutstanding>
        <approxSaleDate>11/25/2024</approxSaleDate>
        <securitiesExchangeName>Nasdaq</securitiesExchangeName>
      </securitiesInformation>
      <securitiesToBeSold>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <acquiredDate>07/13/2021</acquiredDate>
        <natureOfAcquisitionTransaction>Grant</natureOfAcquisitionTransaction>
        <nameOfPersonfromWhomAcquired>Matthew Shair, who acquired the shares from issuer on 02/17/17, transferred to trust on 7/13/21</nameOfPersonfromWhomAcquired>
        <isGiftTransaction>N</isGiftTransaction>
        <amountOfSecuritiesAcquired>8000</amountOfSecuritiesAcquired>
        <paymentDate>07/13/2021</paymentDate>
        <natureOfPayment>Transfer</natureOfPayment>
      </securitiesToBeSold>
      <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Matthew Shair 2021 Irrevocable Trust</name>
          <address>
            <com:street1>One Broadway, 14th floor</com:street1>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>08/26/2024</saleDate>
        <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
        <grossProceeds>168914</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Matthew Shair 2021 Irrevocable Trust</name>
          <address>
            <com:street1>One Broadway, 14th floor</com:street1>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>09/23/2024</saleDate>
        <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
        <grossProceeds>205496</grossProceeds>
      </securitiesSoldInPast3Months>
      <securitiesSoldInPast3Months>
        <sellerDetails>
          <name>Matthew Shair 2021 Irrevocable Trust</name>
          <address>
            <com:street1>One Broadway, 14th floor</com:street1>
            <com:city>Cambridge</com:city>
            <com:stateOrCountry>MA</com:stateOrCountry>
            <com:zipCode>02142</com:zipCode>
          </address>
        </sellerDetails>
        <securitiesClassTitle>Class A Common</securitiesClassTitle>
        <saleDate>10/28/2024</saleDate>
        <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
        <grossProceeds>183460</grossProceeds>
      </securitiesSoldInPast3Months>
      <remarks>The shares represented on this filing are shares to be sold in the next 3 months by the Matthew Shair 2021 Irrevocable Trust</remarks>
      <noticeSignature>
        <noticeDate>11/25/2024</noticeDate>
        <planAdoptionDates>
          <planAdoptionDate>12/21/2023</planAdoptionDate>
        </planAdoptionDates>
        <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Matthew Shair</signature>
      </noticeSignature>
    </formData>
  </edgarSubmission>
metadata_documents: [{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5040}]
text: 144
  0001862123
  XXXXXXXX
  LIVE
  0001861560
  Nuvalent Inc
  001-40671
  One Broadway, 14th Floor
  Cambridge
  MA
  02142
  857-357-7000
  Matthew Shair
  Director
  Class A Common
  J.P. Morgan Securities LLC
  390 Madison Avenue
  6th Floor
  New York
  NY
  10017
  8000
  771600
  65617305
  11/25/2024
  Nasdaq
  Class A Common
  07/13/2021
  Grant
  Matthew Shair, who acquired the shares from issuer on 02/17/17, transferred to trust on 7/13/21
  N
  8000
  07/13/2021
  Transfer
  N
  Matthew Shair 2021 Irrevocable Trust
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  08/26/2024
  2000
  168914
  Matthew Shair 2021 Irrevocable Trust
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  09/23/2024
  2000
  205496
  Matthew Shair 2021 Irrevocable Trust
  One Broadway, 14th floor
  Cambridge
  MA
  02142
  Class A Common
  10/28/2024
  2000
  183460
  The shares represented on this filing are shares to be sold in the next 3 months by the Matthew Shair 2021 Irrevocable Trust
  11/25/2024
  12/21/2023
  /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Matthew Shair