content: <?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
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  <liveTestFlag>LIVE</liveTestFlag>
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  <issuerAddress>
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  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">02139</zipCode>
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  <issuerContactPhone>617-651-8851</issuerContactPhone>
  <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Greg Tourangeau</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
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  <name>Merrill Lynch, Pierce, Fenner &amp; Smith Inc</name>
  <address>
  <street1 xmlns="http://www.sec.gov/edgar/common">1400 American Blvd.</street1>
  <city xmlns="http://www.sec.gov/edgar/common">Pennington</city>
  <stateOrCountry xmlns="http://www.sec.gov/edgar/common">NJ</stateOrCountry>
  <zipCode xmlns="http://www.sec.gov/edgar/common">08534</zipCode>
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  <approxSaleDate>03/08/2024</approxSaleDate>
  <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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  <natureOfAcquisitionTransaction>Stock option exercises</natureOfAcquisitionTransaction>
  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2110</amountOfSecuritiesAcquired>
  <paymentDate>04/27/2021</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
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  <securitiesToBeSold>
  <securitiesClassTitle>Common Stock</securitiesClassTitle>
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  <isGiftTransaction>N</isGiftTransaction>
  <amountOfSecuritiesAcquired>2774</amountOfSecuritiesAcquired>
  <paymentDate>06/28/2021</paymentDate>
  <natureOfPayment>Cash</natureOfPayment>
  </securitiesToBeSold>
  <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
  <noticeSignature>
  <noticeDate>03/08/2024</noticeDate>
  <signature>/s/ Greg Tourangeau</signature>
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text: 144
  0001916566
  XXXXXXXX
  LIVE
  0001680581
  Fulcrum Therapeutics, Inc.
  001-38978
  26 Landsdowne St
  Cambridge
  MA
  02139
  617-651-8851
  Greg Tourangeau
  Officer
  Common Stock
  Merrill Lynch, Pierce, Fenner & Smith Inc
  1400 American Blvd.
  Pennington
  NJ
  08534
  4884
  57218.20
  61935171
  03/08/2024
  NASDAQ
  Common Stock
  04/27/2021
  Stock option exercises
  Issuer
  N
  2110
  04/27/2021
  Cash
  Common Stock
  06/28/2021
  Open market purchases
  Issuer
  N
  2774
  06/28/2021
  Cash
  Y
  03/08/2024
  /s/ Greg Tourangeau