<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001985621</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001124105</issuerCik>
            <issuerName>GYRE THERAPEUTICS, INC.</issuerName>
            <secFileNumber>000-51173</secFileNumber>
            <issuerAddress>
                <ns2:street1>12770 High Bluff Drive</ns2:street1>
                <ns2:street2>Suite 150</ns2:street2>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92130</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(619) 949-3681</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CHARLES WU</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>729</noOfUnitsSold>
            <aggregateMarketValue>12393.00</aggregateMarketValue>
            <noOfUnitsOutstanding>85423246</noOfUnitsOutstanding>
            <approxSaleDate>04/03/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>04/03/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>729</amountOfSecuritiesAcquired>
            <paymentDate>04/03/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHARLES WU</name>
                <address>
                    <ns2:street1>12770 High Bluff Drive</ns2:street1>
                    <ns2:street2>Suite 150</ns2:street2>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/02/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>33000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHARLES WU</name>
                <address>
                    <ns2:street1>12770 High Bluff Drive</ns2:street1>
                    <ns2:street2>Suite 150</ns2:street2>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/02/2024</saleDate>
            <amountOfSecuritiesSold>1271</amountOfSecuritiesSold>
            <grossProceeds>21607.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHARLES WU</name>
                <address>
                    <ns2:street1>12770 High Bluff Drive</ns2:street1>
                    <ns2:street2>Suite 150</ns2:street2>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/28/2024</saleDate>
            <amountOfSecuritiesSold>417</amountOfSecuritiesSold>
            <grossProceeds>7193.25</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHARLES WU</name>
                <address>
                    <ns2:street1>12770 High Bluff Drive</ns2:street1>
                    <ns2:street2>Suite 150</ns2:street2>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/28/2024</saleDate>
            <amountOfSecuritiesSold>1000</amountOfSecuritiesSold>
            <grossProceeds>17450.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/03/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Charles Chao Wu</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6319}]
144
0001985621
XXXXXXXX
LIVE
0001124105
GYRE THERAPEUTICS, INC.
000-51173
12770 High Bluff Drive
Suite 150
San Diego
CA
92130
(619) 949-3681
CHARLES WU
Officer
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
729
12393.00
85423246
04/03/2024
NASDAQ
Common
04/03/2024
Stock Option Exercise
Issuer
N
729
04/03/2024
Cash
N
CHARLES WU
12770 High Bluff Drive
Suite 150
San Diego
CA
92130
Common
04/02/2024
2000
33000.00
CHARLES WU
12770 High Bluff Drive
Suite 150
San Diego
CA
92130
Common
04/02/2024
1271
21607.00
CHARLES WU
12770 High Bluff Drive
Suite 150
San Diego
CA
92130
Common
03/28/2024
417
7193.25
CHARLES WU
12770 High Bluff Drive
Suite 150
San Diego
CA
92130
Common
03/28/2024
1000
17450.00
04/03/2024
/s/ Charles Chao Wu