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    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001331453</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
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  <formData>
    <issuerInfo>
      <issuerCik>0001287865</issuerCik>
      <issuerName>MEDICAL PROPERTIES TRUST INC</issuerName>
      <secFileNumber>001-32559</secFileNumber>
      <issuerAddress>
        <com:street1>1000 URBAN CENTER DRIVE</com:street1>
        <com:street2>SUITE 501</com:street2>
        <com:city>BIRMINGHAM</com:city>
        <com:stateOrCountry>AL</com:stateOrCountry>
        <com:zipCode>35242</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>205-969-3755</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Stewart Michael G</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab Corp</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>29000</noOfUnitsSold>
      <aggregateMarketValue>150800.00</aggregateMarketValue>
      <noOfUnitsOutstanding>600600000</noOfUnitsOutstanding>
      <approxSaleDate>05/05/2025</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/06/2006</acquiredDate>
      <natureOfAcquisitionTransaction>Vested Restricted Stock</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1044</amountOfSecuritiesAcquired>
      <paymentDate>12/06/2006</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/09/2007</acquiredDate>
      <natureOfAcquisitionTransaction>Vested Restricted Stock</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>15447</amountOfSecuritiesAcquired>
      <paymentDate>01/09/2007</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/11/2007</acquiredDate>
      <natureOfAcquisitionTransaction>Vested Restricted Stock</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4916</amountOfSecuritiesAcquired>
      <paymentDate>05/11/2007</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/24/2007</acquiredDate>
      <natureOfAcquisitionTransaction>Vested Restricted Stock</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4166</amountOfSecuritiesAcquired>
      <paymentDate>07/24/2007</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/16/2007</acquiredDate>
      <natureOfAcquisitionTransaction>Vested Restricted Stock</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4166</amountOfSecuritiesAcquired>
      <paymentDate>10/16/2007</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/05/2025</noticeDate>
      <signature>Michael G. Stewart</signature>
    </noticeSignature>
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144
0001331453
XXXXXXXX
LIVE
0001287865
MEDICAL PROPERTIES TRUST INC
001-32559
1000 URBAN CENTER DRIVE
SUITE 501
BIRMINGHAM
AL
35242
205-969-3755
Stewart Michael G
Director
Common
Charles Schwab Corp
3000 Schwab Way
Westlake
TX
76262
29000
150800.00
600600000
05/05/2025
NYSE
Common
12/06/2006
Vested Restricted Stock
Issuer
N
1044
12/06/2006
Equity Compensation
Common
01/09/2007
Vested Restricted Stock
Issuer
N
15447
01/09/2007
Equity Compensation
Common
05/11/2007
Vested Restricted Stock
Issuer
N
4916
05/11/2007
Equity Compensation
Common
07/24/2007
Vested Restricted Stock
Issuer
N
4166
07/24/2007
Equity Compensation
Common
10/16/2007
Vested Restricted Stock
Issuer
N
4166
10/16/2007
Equity Compensation
Y
05/05/2025
Michael G. Stewart