<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001653053</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001816736</issuerCik>
            <issuerName>DISC MEDICINE, INC.</issuerName>
            <secFileNumber>001-39438</secFileNumber>
            <issuerAddress>
                <ns2:street1>321 Arsenal Street,Suite101</ns2:street1>
                <ns2:city>Watertown</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02472</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6176749274</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JEAN FRANCHI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2031</noOfUnitsSold>
            <aggregateMarketValue>116457.54</aggregateMarketValue>
            <noOfUnitsOutstanding>34634295</noOfUnitsOutstanding>
            <approxSaleDate>07/17/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/15/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2031</amountOfSecuritiesAcquired>
            <paymentDate>02/15/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JEAN FRANCHI</name>
                <address>
                    <ns2:street1>321 Arsenal Street,Suite101</ns2:street1>
                    <ns2:city>Watertown</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02472</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/10/2025</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>115000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JEAN FRANCHI</name>
                <address>
                    <ns2:street1>321 Arsenal Street,Suite101</ns2:street1>
                    <ns2:city>Watertown</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02472</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/16/2025</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>104518.80</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>07/17/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/10/2025</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jean Franchi</signature>
        </noticeSignature>
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144
0001653053
XXXXXXXX
LIVE
0001816736
DISC MEDICINE, INC.
001-39438
321 Arsenal Street,Suite101
Watertown
MA
02472
6176749274
JEAN FRANCHI
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
2031
116457.54
34634295
07/17/2025
NASDAQ
Common
02/15/2025
Restricted Stock Units
Issuer
N
2031
02/15/2025
N/A
N
10b5-1 Sales for JEAN FRANCHI
321 Arsenal Street,Suite101
Watertown
MA
02472
Common
07/10/2025
2000
115000.00
10b5-1 Sales for JEAN FRANCHI
321 Arsenal Street,Suite101
Watertown
MA
02472
Common
06/16/2025
2000
104518.80
07/17/2025
03/10/2025
/s/ Jean Franchi