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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001709900</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
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    <formData>
        <issuerInfo>
            <issuerCik>0001393434</issuerCik>
            <issuerName>OCULAR THERAPEUTIX, INC.</issuerName>
            <secFileNumber>001-36554</secFileNumber>
            <issuerAddress>
                <ns2:street1>15 Crosby Drive</ns2:street1>
                <ns2:city>Bedford</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>01730</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>781-895-3235</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ANTONY MATTESSICH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Former Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>106165</noOfUnitsSold>
            <aggregateMarketValue>619267.25</aggregateMarketValue>
            <noOfUnitsOutstanding>154888915</noOfUnitsOutstanding>
            <approxSaleDate>05/30/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/15/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>106165</amountOfSecuritiesAcquired>
            <paymentDate>05/15/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ANTONY MATTESSICH</name>
                <address>
                    <ns2:street1>15 Crosby Drive</ns2:street1>
                    <ns2:city>Bedford</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>01730</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/29/2024</saleDate>
            <amountOfSecuritiesSold>82808</amountOfSecuritiesSold>
            <grossProceeds>483756.06</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/30/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Antony C. Mattessich</signature>
        </noticeSignature>
    </formData>
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144
0001709900
XXXXXXXX
LIVE
0001393434
OCULAR THERAPEUTIX, INC.
001-36554
15 Crosby Drive
Bedford
MA
01730
781-895-3235
ANTONY MATTESSICH
Former Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
106165
619267.25
154888915
05/30/2024
NASDAQ
Common
05/15/2024
Restricted stock vesting under a registered plan
Issuer
N
106165
05/15/2024
Not Applicable
N
ANTONY MATTESSICH
15 Crosby Drive
Bedford
MA
01730
Common
05/29/2024
82808
483756.06
05/30/2024
/s/ Antony C. Mattessich