<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001726378</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000831547</issuerCik>
      <issuerName>SPECTRUM PHARMACEUTICALS INC</issuerName>
      <secFileNumber>001-35006</secFileNumber>
      <issuerAddress>
        <com:street1>11500 S. EASTERN AVE., SUITE 240</com:street1>
        <com:city>HENDERSON</com:city>
        <com:stateOrCountry>NV</com:stateOrCountry>
        <com:zipCode>89052</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>702-835-6300</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Riga Thomas J</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>18153</noOfUnitsSold>
      <aggregateMarketValue>14870.94</aggregateMarketValue>
      <noOfUnitsOutstanding>203205510</noOfUnitsOutstanding>
      <approxSaleDate>03/14/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/13/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>18153</amountOfSecuritiesAcquired>
      <paymentDate>03/13/2023</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Thomas Riga</name>
        <address>
          <com:street1>Pilot House- Lewis Wharf, 2 Atlantic Ave</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/03/2023</saleDate>
      <amountOfSecuritiesSold>23929</amountOfSecuritiesSold>
      <grossProceeds>9145.66</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Thomas Riga</name>
        <address>
          <com:street1>Pilot House- Lewis Wharf, 2 Atlantic Ave</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/04/2023</saleDate>
      <amountOfSecuritiesSold>23950</amountOfSecuritiesSold>
      <grossProceeds>9101.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Thomas Riga</name>
        <address>
          <com:street1>Pilot House- Lewis Wharf, 2 Atlantic Ave</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/30/2023</saleDate>
      <amountOfSecuritiesSold>69389</amountOfSecuritiesSold>
      <grossProceeds>37775.37</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Thomas Riga</name>
        <address>
          <com:street1>Pilot House- Lewis Wharf, 2 Atlantic Ave</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/31/2023</saleDate>
      <amountOfSecuritiesSold>107424</amountOfSecuritiesSold>
      <grossProceeds>70806.37</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Thomas Riga</name>
        <address>
          <com:street1>Pilot House- Lewis Wharf, 2 Atlantic Ave</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/22/2023</saleDate>
      <amountOfSecuritiesSold>14607</amountOfSecuritiesSold>
      <grossProceeds>11115.93</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Thomas Riga</name>
        <address>
          <com:street1>Pilot House- Lewis Wharf, 2 Atlantic Ave</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/23/2023</saleDate>
      <amountOfSecuritiesSold>22402</amountOfSecuritiesSold>
      <grossProceeds>17249.54</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>03/14/2023</noticeDate>
      <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Thomas Riga</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6728}]
144
0001726378
XXXXXXXX
LIVE
0000831547
SPECTRUM PHARMACEUTICALS INC
001-35006
11500 S. EASTERN AVE., SUITE 240
HENDERSON
NV
89052
702-835-6300
Riga Thomas J
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
18153
14870.94
203205510
03/14/2023
NASDAQ
Common
03/13/2023
Restricted Stock Vesting
Issuer
N
18153
03/13/2023
Compensation
N
Thomas Riga
Pilot House- Lewis Wharf, 2 Atlantic Ave
6th Floor
Boston
MA
02110
Common
01/03/2023
23929
9145.66
Thomas Riga
Pilot House- Lewis Wharf, 2 Atlantic Ave
6th Floor
Boston
MA
02110
Common
01/04/2023
23950
9101.00
Thomas Riga
Pilot House- Lewis Wharf, 2 Atlantic Ave
6th Floor
Boston
MA
02110
Common
01/30/2023
69389
37775.37
Thomas Riga
Pilot House- Lewis Wharf, 2 Atlantic Ave
6th Floor
Boston
MA
02110
Common
01/31/2023
107424
70806.37
Thomas Riga
Pilot House- Lewis Wharf, 2 Atlantic Ave
6th Floor
Boston
MA
02110
Common
02/22/2023
14607
11115.93
Thomas Riga
Pilot House- Lewis Wharf, 2 Atlantic Ave
6th Floor
Boston
MA
02110
Common
02/23/2023
22402
17249.54
03/14/2023
/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Thomas Riga