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            <relationshipsToIssuer>
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                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
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                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
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            <approxSaleDate>02/12/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
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            <isGiftTransaction>N</isGiftTransaction>
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            <paymentDate>02/12/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
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                    <ns2:stateOrCountry>NC</ns2:stateOrCountry>
                    <ns2:zipCode>27709</ns2:zipCode>
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            <grossProceeds>2121.33</grossProceeds>
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                    <ns2:stateOrCountry>NC</ns2:stateOrCountry>
                    <ns2:zipCode>27709</ns2:zipCode>
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            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
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            <amountOfSecuritiesSold>3019</amountOfSecuritiesSold>
            <grossProceeds>9415.96</grossProceeds>
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                    <ns2:zipCode>27709</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/11/2023</saleDate>
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            <grossProceeds>65659.08</grossProceeds>
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                <address>
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                    <ns2:stateOrCountry>NC</ns2:stateOrCountry>
                    <ns2:zipCode>27709</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/11/2023</saleDate>
            <amountOfSecuritiesSold>12400</amountOfSecuritiesSold>
            <grossProceeds>49862.88</grossProceeds>
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        <noticeSignature>
            <noticeDate>02/12/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/05/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Rajesh Kumar Malik</signature>
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144
0001706853
XXXXXXXX
LIVE
0001560241
G1 THERAPEUTICS, INC.
001-38096
700 Park Offices Drive, Suite 200
Research Triangle Park
NC
27709
(919) 213-9835
RAJESH MALIK
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
28600
132143.44
51843669
02/12/2024
NASDAQ
Common
02/12/2024
Stock Option Exercise
Issuer
N
28600
02/12/2024
Cash
N
RAJESH MALIK
700 Park Offices Drive, Suite 200
Research Triangle Park
NC
27709
Common
01/05/2024
721
2121.33
RAJESH MALIK
700 Park Offices Drive, Suite 200
Research Triangle Park
NC
27709
Common
01/04/2024
3019
9415.96
RAJESH MALIK
700 Park Offices Drive, Suite 200
Research Triangle Park
NC
27709
Common
12/11/2023
21439
65659.08
RAJESH MALIK
700 Park Offices Drive, Suite 200
Research Triangle Park
NC
27709
Common
12/11/2023
12400
49862.88
02/12/2024
05/05/2023
/s/ Rajesh Kumar Malik