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      <secFileNumber>000-26727</secFileNumber>
      <issuerAddress>
        <com:street1>105 DIGITAL DRIVE</com:street1>
        <com:city>NOVATO</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94949</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>4155066700</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BIENAIME JEAN JACQUES</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
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      <aggregateMarketValue>2864700.00</aggregateMarketValue>
      <noOfUnitsOutstanding>187700942</noOfUnitsOutstanding>
      <approxSaleDate>05/09/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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      <natureOfAcquisitionTransaction>Option Granted - 05/15/2013</natureOfAcquisitionTransaction>
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      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>30000</amountOfSecuritiesAcquired>
      <paymentDate>05/09/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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      <sellerDetails>
        <name>Jean-Jacques Bienaime</name>
        <address>
          <com:street1>770 Lindaro Street</com:street1>
          <com:city>San Rafael</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94901</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/10/2023</saleDate>
      <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
      <grossProceeds>1651650.00</grossProceeds>
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          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94901</com:zipCode>
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      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/13/2023</saleDate>
      <amountOfSecuritiesSold>6000</amountOfSecuritiesSold>
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      <grossProceeds>1384200.00</grossProceeds>
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    <securitiesSoldInPast3Months>
      <sellerDetails>
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          <com:stateOrCountry>CA</com:stateOrCountry>
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        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/13/2023</saleDate>
      <amountOfSecuritiesSold>8000</amountOfSecuritiesSold>
      <grossProceeds>723600.00</grossProceeds>
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    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Jean-Jacques Bienaime</name>
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          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94901</com:zipCode>
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      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>04/06/2023</saleDate>
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    <noticeSignature>
      <noticeDate>05/09/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>11/17/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Jean-Jacques Bienaime</signature>
    </noticeSignature>
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144
0001221590
XXXXXXXX
LIVE
0001048477
BIOMARIN PHARMACEUTICAL INC
000-26727
105 DIGITAL DRIVE
NOVATO
CA
94949
4155066700
BIENAIME JEAN JACQUES
Officer
Director
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
30000
2864700.00
187700942
05/09/2023
NASDAQ
Common
05/09/2023
Option Granted - 05/15/2013
Issuer
N
30000
05/09/2023
Cash
N
Jean-Jacques Bienaime
770 Lindaro Street
San Rafael
CA
94901
Common
02/10/2023
15000
1651650.00
Jean-Jacques Bienaime
770 Lindaro Street
San Rafael
CA
94901
Common
02/13/2023
6000
645900.00
Jean-Jacques Bienaime
770 Lindaro Street
San Rafael
CA
94901
Common
03/10/2023
15000
1384200.00
Jean-Jacques Bienaime
770 Lindaro Street
San Rafael
CA
94901
Common
03/13/2023
8000
723600.00
Jean-Jacques Bienaime
770 Lindaro Street
San Rafael
CA
94901
Common
04/06/2023
10000
961300.00
Jean-Jacques Bienaime
770 Lindaro Street
San Rafael
CA
94901
Common
04/10/2023
10000
995600.00
05/09/2023
11/17/2022
/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Jean-Jacques Bienaime