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            <filer>
                <filerCredentials>
                    <cik>0001331852</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001880438</issuerCik>
            <issuerName>AN2 THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-41331</secFileNumber>
            <issuerAddress>
                <ns2:street1>1800 EL CAMINO REAL</ns2:street1>
                <ns2:street2>Suite D</ns2:street2>
                <ns2:city>MENLO PARK</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94027</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>202-674-6949</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Z3 TRUST</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>100000</noOfUnitsSold>
            <aggregateMarketValue>1911410.00</aggregateMarketValue>
            <noOfUnitsOutstanding>29741445</noOfUnitsOutstanding>
            <approxSaleDate>01/18/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/15/2018</acquiredDate>
            <natureOfAcquisitionTransaction>Private Acquisition from Issuer/Affiliate</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>100000</amountOfSecuritiesAcquired>
            <paymentDate>08/15/2018</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>01/18/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Joseph S Zakrzewski, trustee</signature>
        </noticeSignature>
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144
0001331852
XXXXXXXX
LIVE
0001880438
AN2 THERAPEUTICS, INC.
001-41331
1800 EL CAMINO REAL
Suite D
MENLO PARK
CA
94027
202-674-6949
Z3 TRUST
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
100000
1911410.00
29741445
01/18/2024
NASDAQ
Common
08/15/2018
Private Acquisition from Issuer/Affiliate
Issuer
N
100000
08/15/2018
Cash
Y
01/18/2024
/s/ Joseph S Zakrzewski, trustee