<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001047058</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001039065</issuerCik>
            <issuerName>OSI SYSTEMS INC</issuerName>
            <secFileNumber>000-23125</secFileNumber>
            <issuerAddress>
                <ns2:street1>12525 Chadron Avenue</ns2:street1>
                <ns2:city>Hawthorne</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>90250</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>310-978-0516</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>THE DEEPIKA CHOPRA TRUST</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>10000</noOfUnitsSold>
            <aggregateMarketValue>1533882.00</aggregateMarketValue>
            <noOfUnitsOutstanding>16710749</noOfUnitsOutstanding>
            <approxSaleDate>11/11/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>07/17/1987</acquiredDate>
            <natureOfAcquisitionTransaction>Founder Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
            <paymentDate>07/17/1987</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings on November 11, 2024 in observance of the federal holiday.</remarks>
        <noticeSignature>
            <noticeDate>11/11/2024</noticeDate>
            <planAdoptionDates/>
            <signature>Deepak Chopra, Trustee</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3463}]
144
0001047058
XXXXXXXX
LIVE
0001039065
OSI SYSTEMS INC
000-23125
12525 Chadron Avenue
Hawthorne
CA
90250
310-978-0516
THE DEEPIKA CHOPRA TRUST
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
10000
1533882.00
16710749
11/11/2024
NASDAQ
common
07/17/1987
Founder Stock
Issuer
N
10000
07/17/1987
Not Applicable
Y
Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings on November 11, 2024 in observance of the federal holiday.
11/11/2024
Deepak Chopra, Trustee