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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>000-50633</secFileNumber>
            <issuerAddress>
                <ns2:street1>350 Oyster Point Boulevard</ns2:street1>
                <ns2:city>South San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 624-3000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROBERT BLUM</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>11500</noOfUnitsSold>
            <aggregateMarketValue>624345.95</aggregateMarketValue>
            <noOfUnitsOutstanding>104853918</noOfUnitsOutstanding>
            <approxSaleDate>07/10/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>07/10/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5767</amountOfSecuritiesAcquired>
            <paymentDate>07/10/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>02/18/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Exercised Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5733</amountOfSecuritiesAcquired>
            <paymentDate>02/18/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT BLUM</name>
                <address>
                    <ns2:street1>350 Oyster Point Boulevard</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/01/2024</saleDate>
            <amountOfSecuritiesSold>11500</amountOfSecuritiesSold>
            <grossProceeds>621621.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT BLUM</name>
                <address>
                    <ns2:street1>350 Oyster Point Boulevard</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/17/2024</saleDate>
            <amountOfSecuritiesSold>11551</amountOfSecuritiesSold>
            <grossProceeds>607565.27</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT BLUM</name>
                <address>
                    <ns2:street1>350 Oyster Point Boulevard</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/17/2024</saleDate>
            <amountOfSecuritiesSold>10949</amountOfSecuritiesSold>
            <grossProceeds>575798.06</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT BLUM</name>
                <address>
                    <ns2:street1>350 Oyster Point Boulevard</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/04/2024</saleDate>
            <amountOfSecuritiesSold>22500</amountOfSecuritiesSold>
            <grossProceeds>1099219.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>07/10/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/05/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Robert Ian Blum</signature>
        </noticeSignature>
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144
0001288859
XXXXXXXX
LIVE
0001061983
CYTOKINETICS, INCORPORATED
000-50633
350 Oyster Point Boulevard
South San Francisco
CA
94080
(650) 624-3000
ROBERT BLUM
Officer
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
11500
624345.95
104853918
07/10/2024
NASDAQ
COMMON
07/10/2024
Stock Option Exercise
ISSUER
N
5767
07/10/2024
Cash
COMMON
02/18/2021
Exercised Shares
ISSUER
N
5733
02/18/2021
Cash
N
ROBERT BLUM
350 Oyster Point Boulevard
South San Francisco
CA
94080
Common
07/01/2024
11500
621621.00
ROBERT BLUM
350 Oyster Point Boulevard
South San Francisco
CA
94080
Common
06/17/2024
11551
607565.27
ROBERT BLUM
350 Oyster Point Boulevard
South San Francisco
CA
94080
Common
06/17/2024
10949
575798.06
ROBERT BLUM
350 Oyster Point Boulevard
South San Francisco
CA
94080
Common
06/04/2024
22500
1099219.50
07/10/2024
03/05/2024
/s/ Robert Ian Blum