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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001422164</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001665918</issuerCik>
      <issuerName>US Foods Holding Corp.</issuerName>
      <secFileNumber>001-37786</secFileNumber>
      <issuerAddress>
        <com:street1>9399 W. HIGGINS RD.</com:street1>
        <com:street2>SUITE 100</com:street2>
        <com:city>ROSEMONT</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60018</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>8477208000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CARRUTHERS COURT D</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Former BOD</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services, LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>9456</noOfUnitsSold>
      <aggregateMarketValue>393230.38</aggregateMarketValue>
      <noOfUnitsOutstanding>232652077</noOfUnitsOutstanding>
      <approxSaleDate>06/05/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/05/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Options Granted - 11/11/2016</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2436</amountOfSecuritiesAcquired>
      <paymentDate>06/05/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/15/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>7020</amountOfSecuritiesAcquired>
      <paymentDate>03/15/2022</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/05/2023</noticeDate>
      <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Court Carruthers</signature>
    </noticeSignature>
  </formData>
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144
0001422164
XXXXXXXX
LIVE
0001665918
US Foods Holding Corp.
001-37786
9399 W. HIGGINS RD.
SUITE 100
ROSEMONT
IL
60018
8477208000
CARRUTHERS COURT D
Former BOD
Common
Fidelity Brokerage Services, LLC
900 Salem Street
Smithfield
RI
02917
9456
393230.38
232652077
06/05/2023
NYSE
Common
06/05/2023
Options Granted - 11/11/2016
Issuer
N
2436
06/05/2023
Cash
Common
03/15/2022
Open Market Purchase
Issuer
N
7020
03/15/2022
Cash
Y
06/05/2023
/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Court Carruthers