<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001519593</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001035267</issuerCik>
            <issuerName>INTUITIVE SURGICAL INC.</issuerName>
            <secFileNumber>000-30713</secFileNumber>
            <issuerAddress>
                <ns2:street1>1020 KIFER ROAD</ns2:street1>
                <ns2:city>SUNNYVALE</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94086</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(408) 523-2100</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>DAVID ROSA</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>40764</noOfUnitsSold>
            <aggregateMarketValue>12196446.13</aggregateMarketValue>
            <noOfUnitsOutstanding>350398068</noOfUnitsOutstanding>
            <approxSaleDate>04/24/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>04/24/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>40764</amountOfSecuritiesAcquired>
            <paymentDate>04/24/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>DAVID ROSA</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/21/2023</saleDate>
            <amountOfSecuritiesSold>40800</amountOfSecuritiesSold>
            <grossProceeds>12155172.72</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>DAVID ROSA</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>02/06/2023</saleDate>
            <amountOfSecuritiesSold>45025</amountOfSecuritiesSold>
            <grossProceeds>11279762.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/24/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/02/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ David Joseph Rosa</signature>
        </noticeSignature>
    </formData>
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144
0001519593
XXXXXXXX
LIVE
0001035267
INTUITIVE SURGICAL INC.
000-30713
1020 KIFER ROAD
SUNNYVALE
CA
94086
(408) 523-2100
DAVID ROSA
Officer
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
40764
12196446.13
350398068
04/24/2023
NASD
Common
04/24/2023
Stock Options
Issuer
N
40764
04/24/2023
Cash
N
DAVID ROSA
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
04/21/2023
40800
12155172.72
DAVID ROSA
1020 KIFER ROAD
SUNNYVALE
CA
94086
COMMON
02/06/2023
45025
11279762.00
04/24/2023
08/02/2022
/s/ David Joseph Rosa