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            <filer>
                <filerCredentials>
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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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    <formData>
        <issuerInfo>
            <issuerCik>0001599901</issuerCik>
            <issuerName>AVIDITY BIOSCIENCES INC</issuerName>
            <secFileNumber>001-39321</secFileNumber>
            <issuerAddress>
                <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92121</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8584017900</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KATHLEEN GALLAGHER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>5875</noOfUnitsSold>
            <aggregateMarketValue>191818.75</aggregateMarketValue>
            <noOfUnitsOutstanding>120212301</noOfUnitsOutstanding>
            <approxSaleDate>05/01/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/01/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5875</amountOfSecuritiesAcquired>
            <paymentDate>05/01/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for KATHLEEN GALLAGHER</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/01/2025</saleDate>
            <amountOfSecuritiesSold>5875</amountOfSecuritiesSold>
            <grossProceeds>163485.98</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for KATHLEEN GALLAGHER</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/03/2025</saleDate>
            <amountOfSecuritiesSold>5875</amountOfSecuritiesSold>
            <grossProceeds>172807.25</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for KATHLEEN GALLAGHER</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/03/2025</saleDate>
            <amountOfSecuritiesSold>5875</amountOfSecuritiesSold>
            <grossProceeds>188918.26</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
</remarks>
        <noticeSignature>
            <noticeDate>05/01/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>06/12/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Kathleen Gallagher</signature>
        </noticeSignature>
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144
0002048409
XXXXXXXX
LIVE
0001599901
AVIDITY BIOSCIENCES INC
001-39321
10578 Science Center Drive, Suite 125
San Diego
CA
92121
8584017900
KATHLEEN GALLAGHER
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
5875
191818.75
120212301
05/01/2025
NASDAQ
Common
05/01/2025
Exercise of Stock Options
Issuer
N
5875
05/01/2025
Cash
N
10b5-1 Sales for KATHLEEN GALLAGHER
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
04/01/2025
5875
163485.98
10b5-1 Sales for KATHLEEN GALLAGHER
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
03/03/2025
5875
172807.25
10b5-1 Sales for KATHLEEN GALLAGHER
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
02/03/2025
5875
188918.26
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
05/01/2025
06/12/2024
/s/ Kathleen Gallagher