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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerName>23andMe Holding Co.</issuerName>
            <secFileNumber>001-39587</secFileNumber>
            <issuerAddress>
                <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
                <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 938-6300</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KATHY L HIBBS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>former officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>50462</noOfUnitsSold>
            <aggregateMarketValue>20760.07</aggregateMarketValue>
            <noOfUnitsOutstanding>323542807</noOfUnitsOutstanding>
            <approxSaleDate>06/13/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/21/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>50462</amountOfSecuritiesAcquired>
            <paymentDate>03/21/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>KATHY L HIBBS</name>
                <address>
                    <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>192288</amountOfSecuritiesSold>
            <grossProceeds>79088.05</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Kathy Hibbs</name>
                <address>
                    <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>05/02/2024</saleDate>
            <amountOfSecuritiesSold>38551</amountOfSecuritiesSold>
            <grossProceeds>18565.19</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Kathy Hibbs</name>
                <address>
                    <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>04/18/2024</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>17688.04</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Kathy Hibbs</name>
                <address>
                    <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>04/04/2024</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>18793.01</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Kathy Hibbs</name>
                <address>
                    <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
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            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>03/21/2024</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>17439.98</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/13/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Kathy L Hibbs</signature>
        </noticeSignature>
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144
0001267487
XXXXXXXX
LIVE
0001804591
23andMe Holding Co.
001-39587
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
(650) 938-6300
KATHY L HIBBS
former officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
50462
20760.07
323542807
06/13/2024
NASDAQ
Common
03/21/2021
Exercise of options under a registered plan
Issuer
N
50462
03/21/2021
Cash
N
KATHY L HIBBS
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
06/06/2024
192288
79088.05
Kathy Hibbs
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
common
05/02/2024
38551
18565.19
Kathy Hibbs
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
common
04/18/2024
38548
17688.04
Kathy Hibbs
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
common
04/04/2024
38548
18793.01
Kathy Hibbs
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
common
03/21/2024
38548
17439.98
06/13/2024
/s/ Kathy L Hibbs