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          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



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      <issuerCik>0001804591</issuerCik>
      <issuerName>23andMe Holding Co.</issuerName>
      <secFileNumber>001-39587</secFileNumber>
      <issuerAddress>
        <com:street1>500 Plaza Drive</com:street1>
        <com:city>Secaucus</com:city>
        <com:stateOrCountry>NJ</com:stateOrCountry>
        <com:zipCode>07860</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>650-938-6300</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Quest Diagnostics Ventures LLC</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>None</relationshipToIssuer>
      </relationshipsToIssuer>
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    <securitiesInformation>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Goldman Sachs &amp; Co. LLC</name>
        <address>
          <com:street1>200 West Street</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10282-2102</com:zipCode>
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      <noOfUnitsSold>1032867</noOfUnitsSold>
      <aggregateMarketValue>3150244.35</aggregateMarketValue>
      <noOfUnitsOutstanding>286738037</noOfUnitsOutstanding>
      <approxSaleDate>12/08/2022</approxSaleDate>
      <securitiesExchangeName>NASDAQ GS</securitiesExchangeName>
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    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <acquiredDate>11/01/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Stock consideration received as part of 23andMe acquisition of Lemonaid Health.</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>23andMe Holding Co.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1032867</amountOfSecuritiesAcquired>
      <paymentDate>11/01/2021</paymentDate>
      <natureOfPayment>Merger proceeds</natureOfPayment>
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    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>12/07/2022</noticeDate>
      <signature>William J. O'Shaughnessy, Jr.</signature>
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144
0001956683
XXXXXXXX
LIVE
0001804591
23andMe Holding Co.
001-39587
500 Plaza Drive
Secaucus
NJ
07860
650-938-6300
Quest Diagnostics Ventures LLC
None
Class A Common Stock
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282-2102
1032867
3150244.35
286738037
12/08/2022
NASDAQ GS
Class A Common Stock
11/01/2021
Stock consideration received as part of 23andMe acquisition of Lemonaid Health.
23andMe Holding Co.
N
1032867
11/01/2021
Merger proceeds
Y
12/07/2022
William J. O'Shaughnessy, Jr.