<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001539215</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001356576</issuerCik>
            <issuerName>SUPERNUS PHARMACEUTICALS, INC.</issuerName>
            <secFileNumber>001-35518</secFileNumber>
            <issuerAddress>
                <ns2:street1>9715 Key West Avenue</ns2:street1>
                <ns2:city>Rockville</ns2:city>
                <ns2:stateOrCountry>MD</ns2:stateOrCountry>
                <ns2:zipCode>20850</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>3018382500</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PADMANABH BHATT</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>22000</noOfUnitsSold>
            <aggregateMarketValue>848100.00</aggregateMarketValue>
            <noOfUnitsOutstanding>55219273</noOfUnitsOutstanding>
            <approxSaleDate>01/27/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/27/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>22000</amountOfSecuritiesAcquired>
            <paymentDate>01/27/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PADMANABH P BHATT</name>
                <address>
                    <ns2:street1>9715 Key West Avenue</ns2:street1>
                    <ns2:city>Rockville</ns2:city>
                    <ns2:stateOrCountry>MD</ns2:stateOrCountry>
                    <ns2:zipCode>20850</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/03/2024</saleDate>
            <amountOfSecuritiesSold>21495</amountOfSecuritiesSold>
            <grossProceeds>788485.09</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>01/27/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/03/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Padmanabh Bhatt</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001539215
XXXXXXXX
LIVE
0001356576
SUPERNUS PHARMACEUTICALS, INC.
001-35518
9715 Key West Avenue
Rockville
MD
20850
3018382500
PADMANABH BHATT
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
22000
848100.00
55219273
01/27/2025
NASDAQ
Common
01/27/2025
Exercise of Stock Options
Issuer
N
22000
01/27/2025
Cash
N
10b5-1 Sales for PADMANABH P BHATT
9715 Key West Avenue
Rockville
MD
20850
Common
12/03/2024
21495
788485.09
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
01/27/2025
09/03/2024
/s/ Padmanabh Bhatt