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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>001-39438</secFileNumber>
            <issuerAddress>
                <ns2:street1>321 Arsenal Street</ns2:street1>
                <ns2:street2>Suite 101</ns2:street2>
                <ns2:city>Watertown</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02472</ns2:zipCode>
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            <issuerContactPhone>(617) 674-9274</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BRIAN MACDONALD</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
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            <securitiesClassTitle>Common</securitiesClassTitle>
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                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
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            <aggregateMarketValue>1248908.16</aggregateMarketValue>
            <noOfUnitsOutstanding>24140428</noOfUnitsOutstanding>
            <approxSaleDate>02/06/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/06/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>18600</amountOfSecuritiesAcquired>
            <paymentDate>02/06/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <address>
                    <ns2:street1>321 Arsenal Street</ns2:street1>
                    <ns2:street2>Suite 101</ns2:street2>
                    <ns2:city>Watertown</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02472</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/04/2024</saleDate>
            <amountOfSecuritiesSold>2276</amountOfSecuritiesSold>
            <grossProceeds>137367.00</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
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                <address>
                    <ns2:street1>321 Arsenal Street</ns2:street1>
                    <ns2:street2>Suite 101</ns2:street2>
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                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02472</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/03/2024</saleDate>
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                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02472</ns2:zipCode>
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            <saleDate>01/02/2024</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>296763.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>02/06/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Brian Richard MacDonald</signature>
        </noticeSignature>
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144
0001952556
XXXXXXXX
LIVE
0001816736
DISC MEDICINE, INC.
001-39438
321 Arsenal Street
Suite 101
Watertown
MA
02472
(617) 674-9274
BRIAN MACDONALD
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
18600
1248908.16
24140428
02/06/2024
NASDAQ
Common
02/06/2024
Exercise of options under a registered plan
Issuer
N
18600
02/06/2024
Cash
N
Brian MacDonald
321 Arsenal Street
Suite 101
Watertown
MA
02472
Common
01/04/2024
2276
137367.00
Brian MacDonald
321 Arsenal Street
Suite 101
Watertown
MA
02472
Common
01/03/2024
5000
300963.00
Brian MacDonald
321 Arsenal Street
Suite 101
Watertown
MA
02472
Common
01/02/2024
5000
296763.00
02/06/2024
/s/ Brian Richard MacDonald