<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001298709</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001711279</issuerCik>
            <issuerName>KRYSTAL BIOTECH INC</issuerName>
            <secFileNumber>001-38210</secFileNumber>
            <issuerAddress>
                <ns2:street1>2100 Wharton Street</ns2:street1>
                <ns2:street2>Suite 701</ns2:street2>
                <ns2:city>Pittsburgh</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>15203</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(412) 586-5830</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KRISH KRISHNAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>25000</noOfUnitsSold>
            <aggregateMarketValue>2905977.50</aggregateMarketValue>
            <noOfUnitsOutstanding>25799738</noOfUnitsOutstanding>
            <approxSaleDate>05/31/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/31/2017</acquiredDate>
            <natureOfAcquisitionTransaction>Founder Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>25000</amountOfSecuritiesAcquired>
            <paymentDate>03/31/2017</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Suma Krishnan</name>
                <address>
                    <ns2:street1>2100 Wharton Street</ns2:street1>
                    <ns2:street2>Suite 701</ns2:street2>
                    <ns2:city>Pittsburgh</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>15203</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/17/2023</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>2190200.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Krish Krishnan</name>
                <address>
                    <ns2:street1>2100 Wharton Street</ns2:street1>
                    <ns2:street2>Suite 701</ns2:street2>
                    <ns2:city>Pittsburgh</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>15203</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/17/2023</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>2190200.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/31/2023</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Krish Krishnan</signature>
        </noticeSignature>
    </formData>
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144
0001298709
XXXXXXXX
LIVE
0001711279
KRYSTAL BIOTECH INC
001-38210
2100 Wharton Street
Suite 701
Pittsburgh
PA
15203
(412) 586-5830
KRISH KRISHNAN
Officer
10% Stockholder
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
25000
2905977.50
25799738
05/31/2023
NASD
Common
03/31/2017
Founder Stock
Issuer
N
25000
03/31/2017
Cash
N
Suma Krishnan
2100 Wharton Street
Suite 701
Pittsburgh
PA
15203
Common
04/17/2023
25000
2190200.00
Krish Krishnan
2100 Wharton Street
Suite 701
Pittsburgh
PA
15203
Common
04/17/2023
25000
2190200.00
05/31/2023
/s/ Krish Krishnan