<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001612098</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
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    <issuerInfo>
      <issuerCik>0000927653</issuerCik>
      <issuerName>MCKESSON CORP</issuerName>
      <secFileNumber>001-13252</secFileNumber>
      <issuerAddress>
        <com:street1>6555 STATE HIGHWAY 161</com:street1>
        <com:city>IRVING</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>75039</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>972-446-4800</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Schechter Lori A.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>11195</noOfUnitsSold>
      <aggregateMarketValue>4178869.60</aggregateMarketValue>
      <noOfUnitsOutstanding>135602262</noOfUnitsOutstanding>
      <approxSaleDate>05/31/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/23/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11195</amountOfSecuritiesAcquired>
      <paymentDate>05/23/2023</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lori Schechter</name>
        <address>
          <com:street1>6555 State Hwy 161</com:street1>
          <com:city>Irving</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75039</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/26/2023</saleDate>
      <amountOfSecuritiesSold>640</amountOfSecuritiesSold>
      <grossProceeds>252403.20</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lori Schechter</name>
        <address>
          <com:street1>6555 State Hwy 161</com:street1>
          <com:city>Irving</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75039</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/30/2023</saleDate>
      <amountOfSecuritiesSold>2542</amountOfSecuritiesSold>
      <grossProceeds>975848.38</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/31/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/15/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Lori Schechter</signature>
    </noticeSignature>
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144
0001612098
XXXXXXXX
LIVE
0000927653
MCKESSON CORP
001-13252
6555 STATE HIGHWAY 161
IRVING
TX
75039
972-446-4800
Schechter Lori A.
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
11195
4178869.60
135602262
05/31/2023
NYSE
Common
05/23/2023
Restricted Stock Vesting
Issuer
N
11195
05/23/2023
Compensation
N
Lori Schechter
6555 State Hwy 161
Irving
TX
75039
Common
05/26/2023
640
252403.20
Lori Schechter
6555 State Hwy 161
Irving
TX
75039
Common
05/30/2023
2542
975848.38
05/31/2023
08/15/2022
/s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Lori Schechter