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    <filerInfo>
      <filer>
        <filerCredentials>
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          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
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    <issuerInfo>
      <issuerCik>0001847903</issuerCik>
      <issuerName>Centessa Pharmaceuticals plc</issuerName>
      <secFileNumber>001-40445</secFileNumber>
      <issuerAddress>
        <com:street1>3RD FLOOR</com:street1>
        <com:street2>1 ASHLEY ROAD</com:street2>
        <com:city>ALTRINCHAM, CHESHIRE</com:city>
        <com:stateOrCountry>X0</com:stateOrCountry>
        <com:zipCode>WA14 2DT</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>44 7391 789784</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Bush Tia L</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Member of immediate family of any of the foregoing</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>245 Summer Street</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>5000</noOfUnitsSold>
      <aggregateMarketValue>22424.00</aggregateMarketValue>
      <noOfUnitsOutstanding>95169371</noOfUnitsOutstanding>
      <approxSaleDate>05/24/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>11/16/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Open Mkt Purchase</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Open Mkt</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
      <paymentDate>11/16/2022</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Seller is spouse of affiliate.</remarks>
    <noticeSignature>
      <noticeDate>05/24/2023</noticeDate>
      <signature>/s/ Cristina Garcia as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Christopher Bush</signature>
    </noticeSignature>
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144
0001863418
XXXXXXXX
LIVE
0001847903
Centessa Pharmaceuticals plc
001-40445
3RD FLOOR
1 ASHLEY ROAD
ALTRINCHAM, CHESHIRE
X0
WA14 2DT
44 7391 789784
Bush Tia L
Member of immediate family of any of the foregoing
Common
Fidelity Brokerage Services LLC
245 Summer Street
Boston
MA
02110
5000
22424.00
95169371
05/24/2023
NASDAQ
Common
11/16/2022
Open Mkt Purchase
Open Mkt
N
5000
11/16/2022
Cash
Y
Seller is spouse of affiliate.
05/24/2023
/s/ Cristina Garcia as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Christopher Bush