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    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001697107</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001651625</issuerCik>
            <issuerName>AC IMMUNE SA</issuerName>
            <secFileNumber>001-37891</secFileNumber>
            <issuerAddress>
                <ns2:street1>EPFL Innovation Park, Building B</ns2:street1>
                <ns2:city>Lausanne</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41213459121</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ANDREA M. A PFEIFER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>40000</noOfUnitsSold>
            <aggregateMarketValue>148000.00</aggregateMarketValue>
            <noOfUnitsOutstanding>99197829</noOfUnitsOutstanding>
            <approxSaleDate>09/27/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/01/2012</acquiredDate>
            <natureOfAcquisitionTransaction>Previously Exercised Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>40000</amountOfSecuritiesAcquired>
            <paymentDate>06/01/2012</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ANDREA PFEIFER</name>
                <address>
                    <ns2:street1>EPFL Innovation Park, Building B</ns2:street1>
                    <ns2:city>Lausanne</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/23/2024</saleDate>
            <amountOfSecuritiesSold>1865</amountOfSecuritiesSold>
            <grossProceeds>6964.84</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ANDREA PFEIFER</name>
                <address>
                    <ns2:street1>EPFL Innovation Park, Building B</ns2:street1>
                    <ns2:city>Lausanne</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/20/2024</saleDate>
            <amountOfSecuritiesSold>822</amountOfSecuritiesSold>
            <grossProceeds>3045.59</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ANDREA PFEIFER</name>
                <address>
                    <ns2:street1>EPFL Innovation Park, Building B</ns2:street1>
                    <ns2:city>Lausanne</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/19/2024</saleDate>
            <amountOfSecuritiesSold>15513</amountOfSecuritiesSold>
            <grossProceeds>57508.24</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ANDREA PFEIFER</name>
                <address>
                    <ns2:street1>EPFL Innovation Park, Building B</ns2:street1>
                    <ns2:city>Lausanne</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/18/2024</saleDate>
            <amountOfSecuritiesSold>1800</amountOfSecuritiesSold>
            <grossProceeds>6701.04</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 06/01/2012 through 05/11/2016
</remarks>
        <noticeSignature>
            <noticeDate>09/27/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>06/10/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Andrea M.A. Pfeifer</signature>
        </noticeSignature>
    </formData>
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144
0001697107
XXXXXXXX
LIVE
0001651625
AC IMMUNE SA
001-37891
EPFL Innovation Park, Building B
Lausanne
V8
00000
41213459121
ANDREA M. A PFEIFER
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
40000
148000.00
99197829
09/27/2024
NASDAQ
Common
06/01/2012
Previously Exercised Stock Options
Issuer
N
40000
06/01/2012
Cash
N
10b5-1 Sales for ANDREA PFEIFER
EPFL Innovation Park, Building B
Lausanne
V8
00000
Common
09/23/2024
1865
6964.84
10b5-1 Sales for ANDREA PFEIFER
EPFL Innovation Park, Building B
Lausanne
V8
00000
Common
09/20/2024
822
3045.59
10b5-1 Sales for ANDREA PFEIFER
EPFL Innovation Park, Building B
Lausanne
V8
00000
Common
09/19/2024
15513
57508.24
10b5-1 Sales for ANDREA PFEIFER
EPFL Innovation Park, Building B
Lausanne
V8
00000
Common
09/18/2024
1800
6701.04
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 06/01/2012 through 05/11/2016
09/27/2024
06/10/2024
/s/ Andrea M.A. Pfeifer