<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001337904</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001680247</issuerCik>
            <issuerName>PROPETRO HOLDING CORP.</issuerName>
            <secFileNumber>001-38035</secFileNumber>
            <issuerAddress>
                <ns2:street1>1706 South Midkiff</ns2:street1>
                <ns2:city>Midland</ns2:city>
                <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                <ns2:zipCode>79701</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(432) 688-0012</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MICHELE VION</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>21000</noOfUnitsSold>
            <aggregateMarketValue>144593.40</aggregateMarketValue>
            <noOfUnitsOutstanding>115231367</noOfUnitsOutstanding>
            <approxSaleDate>05/30/2023</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>04/24/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>21000</amountOfSecuritiesAcquired>
            <paymentDate>04/24/2021</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/30/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/24/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>MICHELE VION</signature>
        </noticeSignature>
    </formData>
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144
0001337904
XXXXXXXX
LIVE
0001680247
PROPETRO HOLDING CORP.
001-38035
1706 South Midkiff
Midland
TX
79701
(432) 688-0012
MICHELE VION
Director
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
21000
144593.40
115231367
05/30/2023
NYSE
COMMON
04/24/2021
Restricted Stock
ISSUER
N
21000
04/24/2021
Not Applicable
Y
05/30/2023
02/24/2023
MICHELE VION