<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001691494</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001710072</issuerCik>
            <issuerName>EDGEWISE THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-40236</secFileNumber>
            <issuerAddress>
                <ns2:street1>1715 38th Street</ns2:street1>
                <ns2:city>Boulder</ns2:city>
                <ns2:stateOrCountry>CO</ns2:stateOrCountry>
                <ns2:zipCode>80301</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>7202627002</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MARC J SEMIGRAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>50000</noOfUnitsSold>
            <aggregateMarketValue>1499000.00</aggregateMarketValue>
            <noOfUnitsOutstanding>94688517</noOfUnitsOutstanding>
            <approxSaleDate>12/24/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/24/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
            <paymentDate>12/24/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
Sales that were executed on December 24, 2024 are being reported on this Form 144 filed on December 26, 2024 given the EDGAR system was not accepting filings on December 24, 2024, which is being treated as a federal holiday for filing purposes.</remarks>
        <noticeSignature>
            <noticeDate>12/24/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/24/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Marc J Semigran</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3778}]
144
0001691494
XXXXXXXX
LIVE
0001710072
EDGEWISE THERAPEUTICS, INC.
001-40236
1715 38th Street
Boulder
CO
80301
7202627002
MARC J SEMIGRAN
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
50000
1499000.00
94688517
12/24/2024
NASDAQ
Common
12/24/2024
Exercise of Stock Options
Issuer
N
50000
12/24/2024
Cash
Y
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
Sales that were executed on December 24, 2024 are being reported on this Form 144 filed on December 26, 2024 given the EDGAR system was not accepting filings on December 24, 2024, which is being treated as a federal holiday for filing purposes.
12/24/2024
09/24/2024
/s/ Marc J Semigran