<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001558242</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001107843</issuerCik>
            <issuerName>QUALYS, INC.</issuerName>
            <secFileNumber>001-35662</secFileNumber>
            <issuerAddress>
                <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                <ns2:city> Foster City</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94404</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6508016100</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SUMEDH SHRINAND THAKAR</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>28000</noOfUnitsSold>
            <aggregateMarketValue>3937360.00</aggregateMarketValue>
            <noOfUnitsOutstanding>36939262</noOfUnitsOutstanding>
            <approxSaleDate>06/03/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/03/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>28000</amountOfSecuritiesAcquired>
            <paymentDate>06/03/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for SUMEDH SHRINAND THAKAR</name>
                <address>
                    <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                    <ns2:city> Foster City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94404</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>04/15/2024</saleDate>
            <amountOfSecuritiesSold>4034</amountOfSecuritiesSold>
            <grossProceeds>661427.03</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for SUMEDH SHRINAND THAKAR</name>
                <address>
                    <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                    <ns2:city> Foster City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94404</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>03/14/2024</saleDate>
            <amountOfSecuritiesSold>4120</amountOfSecuritiesSold>
            <grossProceeds>690589.37</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months.
The date of acquisition and payment was and will be the date of exercise/sale.</remarks>
        <noticeSignature>
            <noticeDate>06/03/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/28/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Sumedh Shrinand Thakar</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001558242
XXXXXXXX
LIVE
0001107843
QUALYS, INC.
001-35662
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
6508016100
SUMEDH SHRINAND THAKAR
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
28000
3937360.00
36939262
06/03/2024
NASDAQ
Common
06/03/2024
Exercise of Stock Options
Issuer
N
28000
06/03/2024
Cash
N
10b5-1 Sales Plan for SUMEDH SHRINAND THAKAR
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
COMMON
04/15/2024
4034
661427.03
10b5-1 Sales Plan for SUMEDH SHRINAND THAKAR
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
COMMON
03/14/2024
4120
690589.37
The securities to be sold were and will be received upon the exercise of stock options over the next three months.
The date of acquisition and payment was and will be the date of exercise/sale.
06/03/2024
02/28/2024
/s/ Sumedh Shrinand Thakar