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            <issuerAddress>
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                <ns2:street2>Suite 105</ns2:street2>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02453</ns2:zipCode>
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            <issuerContactPhone>617-651-5940</issuerContactPhone>
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            <relationshipsToIssuer>
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                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
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            <approxSaleDate>10/25/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>Common</securitiesClassTitle>
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            <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
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            <paymentDate>06/22/2023</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
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        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>10/25/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>04/16/2024</planAdoptionDate>
            </planAdoptionDates>
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144
0001638474
XXXXXXXX
LIVE
0001636282
SPYRE THERAPEUTICS INC
001-37722
221 Crescent Street Building 23
Suite 105
Waltham
MA
02453
617-651-5940
SESSIONS, LLC
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
7000
235900.00
50792374
10/25/2024
NASDAQ
Common
06/22/2023
Open Market Purchase
Issuer
N
7000
06/22/2023
N/A
Y
10/25/2024
04/16/2024
/s/ Jeffrey W Albers