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    <headerData>
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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001951845</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001816736</issuerCik>
            <issuerName>DISC MEDICINE INC</issuerName>
            <secFileNumber>001-39438</secFileNumber>
            <issuerAddress>
                <ns2:street1>321 Arsenal Street,Suite101</ns2:street1>
                <ns2:city>Watertown</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02472</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>617-674-9274</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JOANNE BRYCE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>5521</noOfUnitsSold>
            <aggregateMarketValue>273841.60</aggregateMarketValue>
            <noOfUnitsOutstanding>19799357</noOfUnitsOutstanding>
            <approxSaleDate>08/01/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/01/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5521</amountOfSecuritiesAcquired>
            <paymentDate>08/01/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JOANNE BRYCE</name>
                <address>
                    <ns2:street1>321 Arsenal Street,Suite101</ns2:street1>
                    <ns2:city>Watertown</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02472</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/28/2023</saleDate>
            <amountOfSecuritiesSold>10072</amountOfSecuritiesSold>
            <grossProceeds>503114.53</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>08/01/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/15/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Joanne Bryce</signature>
        </noticeSignature>
    </formData>
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144
0001951845
XXXXXXXX
LIVE
0001816736
DISC MEDICINE INC
001-39438
321 Arsenal Street,Suite101
Watertown
MA
02472
617-674-9274
JOANNE BRYCE
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
5521
273841.60
19799357
08/01/2023
NASDAQ
Common
08/01/2023
Exercise of Stock Options
Issuer
N
5521
08/01/2023
Cash
N
10b5-1 Sales for JOANNE BRYCE
321 Arsenal Street,Suite101
Watertown
MA
02472
Common
06/28/2023
10072
503114.53
08/01/2023
02/15/2023
/s/ Joanne Bryce