<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001197710</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000724004</issuerCik>
      <issuerName>MESA LABORATORIES INC /CO/</issuerName>
      <secFileNumber>000-11740</secFileNumber>
      <issuerAddress>
        <com:street1>12100 W 6TH AVE</com:street1>
        <com:city>LAKEWOOD</com:city>
        <com:stateOrCountry>CO</com:stateOrCountry>
        <com:zipCode>80228</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>3039878000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sakys John</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2128</noOfUnitsSold>
      <aggregateMarketValue>355397.28</aggregateMarketValue>
      <noOfUnitsOutstanding>5346174</noOfUnitsOutstanding>
      <approxSaleDate>03/24/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/24/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted - 04/01/2013</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1128</amountOfSecuritiesAcquired>
      <paymentDate>03/24/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/24/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted - 04/03/2017</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1000</amountOfSecuritiesAcquired>
      <paymentDate>03/24/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>John Sakys</name>
        <address>
          <com:street1>12100 West Sixth Avenue</com:street1>
          <com:city>Lakewood</com:city>
          <com:stateOrCountry>CO</com:stateOrCountry>
          <com:zipCode>80228</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/23/2023</saleDate>
      <amountOfSecuritiesSold>2100</amountOfSecuritiesSold>
      <grossProceeds>422495.56</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>John Sakys</name>
        <address>
          <com:street1>12100 West Sixth Avenue</com:street1>
          <com:city>Lakewood</com:city>
          <com:stateOrCountry>CO</com:stateOrCountry>
          <com:zipCode>80228</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/09/2023</saleDate>
      <amountOfSecuritiesSold>1000</amountOfSecuritiesSold>
      <grossProceeds>184270.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>John Sakys</name>
        <address>
          <com:street1>12100 West Sixth Avenue</com:street1>
          <com:city>Lakewood</com:city>
          <com:stateOrCountry>CO</com:stateOrCountry>
          <com:zipCode>80228</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/09/2023</saleDate>
      <amountOfSecuritiesSold>400</amountOfSecuritiesSold>
      <grossProceeds>67988.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>John Sakys</name>
        <address>
          <com:street1>12100 West Sixth Avenue</com:street1>
          <com:city>Lakewood</com:city>
          <com:stateOrCountry>CO</com:stateOrCountry>
          <com:zipCode>80228</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/15/2023</saleDate>
      <amountOfSecuritiesSold>1000</amountOfSecuritiesSold>
      <grossProceeds>165710.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>John Sakys</name>
        <address>
          <com:street1>12100 West Sixth Avenue</com:street1>
          <com:city>Lakewood</com:city>
          <com:stateOrCountry>CO</com:stateOrCountry>
          <com:zipCode>80228</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/22/2023</saleDate>
      <amountOfSecuritiesSold>2500</amountOfSecuritiesSold>
      <grossProceeds>429044.75</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>10B5-1 Plan amended on: 06/14/2022</remarks>
    <noticeSignature>
      <noticeDate>03/24/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>12/13/2021</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Jennifer Ruchti, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for John Sakys</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6438}]
144
0001197710
XXXXXXXX
LIVE
0000724004
MESA LABORATORIES INC /CO/
000-11740
12100 W 6TH AVE
LAKEWOOD
CO
80228
3039878000
Sakys John
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
2128
355397.28
5346174
03/24/2023
NASDAQ
Common
03/24/2023
Option Granted - 04/01/2013
Issuer
N
1128
03/24/2023
Cash
Common
03/24/2023
Option Granted - 04/03/2017
Issuer
N
1000
03/24/2023
Cash
N
John Sakys
12100 West Sixth Avenue
Lakewood
CO
80228
Common
01/23/2023
2100
422495.56
John Sakys
12100 West Sixth Avenue
Lakewood
CO
80228
Common
02/09/2023
1000
184270.00
John Sakys
12100 West Sixth Avenue
Lakewood
CO
80228
Common
03/09/2023
400
67988.00
John Sakys
12100 West Sixth Avenue
Lakewood
CO
80228
Common
03/15/2023
1000
165710.00
John Sakys
12100 West Sixth Avenue
Lakewood
CO
80228
Common
03/22/2023
2500
429044.75
10B5-1 Plan amended on: 06/14/2022
03/24/2023
12/13/2021
/s/ Jennifer Ruchti, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for John Sakys