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            <filer>
                <filerCredentials>
                    <cik>0001551778</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001061983</issuerCik>
            <issuerName>CYTOKINETICS, INCORPORATED</issuerName>
            <secFileNumber>000-50633</secFileNumber>
            <issuerAddress>
                <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6506243000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>FADY MALIK</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>12000</noOfUnitsSold>
            <aggregateMarketValue>431880.00</aggregateMarketValue>
            <noOfUnitsOutstanding>118410689</noOfUnitsOutstanding>
            <approxSaleDate>04/08/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>04/08/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>12000</amountOfSecuritiesAcquired>
            <paymentDate>04/08/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/18/2025</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>87162.20</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/17/2025</saleDate>
            <amountOfSecuritiesSold>4389</amountOfSecuritiesSold>
            <grossProceeds>194783.82</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/06/2025</saleDate>
            <amountOfSecuritiesSold>8228</amountOfSecuritiesSold>
            <grossProceeds>356025.56</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/04/2025</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>85000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/03/2025</saleDate>
            <amountOfSecuritiesSold>2449</amountOfSecuritiesSold>
            <grossProceeds>105013.12</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/18/2025</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>91960.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/04/2025</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>96120.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/21/2025</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>91840.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
</remarks>
        <noticeSignature>
            <noticeDate>04/08/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/16/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Fady Malik</signature>
        </noticeSignature>
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144
0001551778
XXXXXXXX
LIVE
0001061983
CYTOKINETICS, INCORPORATED
000-50633
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
6506243000
FADY MALIK
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
12000
431880.00
118410689
04/08/2025
NASDAQ
Common
04/08/2025
Exercise of Stock Options
Issuer
N
12000
04/08/2025
Cash
N
10b5-1 Sales for FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
03/18/2025
2000
87162.20
FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
03/17/2025
4389
194783.82
FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
03/06/2025
8228
356025.56
10b5-1 Sales for FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
03/04/2025
2000
85000.00
FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
03/03/2025
2449
105013.12
10b5-1 Sales for FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
02/18/2025
2000
91960.00
10b5-1 Sales for FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
02/04/2025
2000
96120.00
10b5-1 Sales for FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
01/21/2025
2000
91840.00
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
04/08/2025
09/16/2024
/s/ Fady Malik