<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001551778</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001061983</issuerCik>
            <issuerName>CYTOKINETICS, INCORPORATED</issuerName>
            <secFileNumber>000-50633</secFileNumber>
            <issuerAddress>
                <ns2:street1>350 Oyster Point Boulevard</ns2:street1>
                <ns2:city>South San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 624-3000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>FADY MALIK</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>4000</noOfUnitsSold>
            <aggregateMarketValue>136858.80</aggregateMarketValue>
            <noOfUnitsOutstanding>95588756</noOfUnitsOutstanding>
            <approxSaleDate>04/13/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>03/01/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3446</amountOfSecuritiesAcquired>
            <paymentDate>03/01/2021</paymentDate>
            <natureOfPayment>None</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>02/27/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>554</amountOfSecuritiesAcquired>
            <paymentDate>02/27/2020</paymentDate>
            <natureOfPayment>None</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FADY MALIK</name>
                <address>
                    <ns2:street1>350 Oyster Point Boulevard</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>03/09/2023</saleDate>
            <amountOfSecuritiesSold>4000</amountOfSecuritiesSold>
            <grossProceeds>156168.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FADY MALIK</name>
                <address>
                    <ns2:street1>350 Oyster Point Boulevard</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>02/09/2023</saleDate>
            <amountOfSecuritiesSold>11000</amountOfSecuritiesSold>
            <grossProceeds>480417.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/13/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/20/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Fady Ibrahim Malik</signature>
        </noticeSignature>
    </formData>
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144
0001551778
XXXXXXXX
LIVE
0001061983
CYTOKINETICS, INCORPORATED
000-50633
350 Oyster Point Boulevard
South San Francisco
CA
94080
(650) 624-3000
FADY MALIK
Officer
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
4000
136858.80
95588756
04/13/2023
NASD
COMMON
03/01/2021
Restricted Stock
Issuer
N
3446
03/01/2021
None
COMMON
02/27/2020
Restricted Stock
Issuer
N
554
02/27/2020
None
N
FADY MALIK
350 Oyster Point Boulevard
South San Francisco
CA
94080
COMMON
03/09/2023
4000
156168.00
FADY MALIK
350 Oyster Point Boulevard
South San Francisco
CA
94080
COMMON
02/09/2023
11000
480417.00
04/13/2023
12/20/2022
/s/ Fady Ibrahim Malik