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            <issuerCik>0001042074</issuerCik>
            <issuerName>CYMABAY THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-36500</secFileNumber>
            <issuerAddress>
                <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                <ns2:city>Newark</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94560</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 293-8800</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CHARLES MCWHERTER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>21749</noOfUnitsSold>
            <aggregateMarketValue>197385.22</aggregateMarketValue>
            <noOfUnitsOutstanding>97513179</noOfUnitsOutstanding>
            <approxSaleDate>05/18/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>05/18/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>21749</amountOfSecuritiesAcquired>
            <paymentDate>05/18/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/18/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/24/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>Charles McWherter</signature>
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144
0001588862
XXXXXXXX
LIVE
0001042074
CYMABAY THERAPEUTICS, INC.
001-36500
7575 Gateway Blvd, Suite 110
Newark
CA
94560
(510) 293-8800
CHARLES MCWHERTER
Officer
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
21749
197385.22
97513179
05/18/2023
NASD
COMMON
05/18/2023
Stock Option Exercise
ISSUER
N
21749
05/18/2023
Cash
Y
05/18/2023
02/24/2023
Charles McWherter