<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001873523</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001830214</issuerCik>
      <issuerName>Ginkgo Bioworks Holdings, Inc.</issuerName>
      <secFileNumber>001-40097</secFileNumber>
      <issuerAddress>
        <com:street1>27 DRYDOCK AVENUE</com:street1>
        <com:street2>8TH FLOOR</com:street2>
        <com:city>BOSTON</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02210</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(877) 442-5362</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Shetty Reshma P.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>37650</noOfUnitsSold>
      <aggregateMarketValue>46309.50</aggregateMarketValue>
      <noOfUnitsOutstanding>1570064412</noOfUnitsOutstanding>
      <approxSaleDate>04/26/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <acquiredDate>10/13/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>37650</amountOfSecuritiesAcquired>
      <paymentDate>10/13/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>01/26/2023</saleDate>
      <amountOfSecuritiesSold>151171</amountOfSecuritiesSold>
      <grossProceeds>267285.45</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>01/27/2023</saleDate>
      <amountOfSecuritiesSold>145906</amountOfSecuritiesSold>
      <grossProceeds>265767.78</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>01/30/2023</saleDate>
      <amountOfSecuritiesSold>156012</amountOfSecuritiesSold>
      <grossProceeds>294628.66</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>01/31/2023</saleDate>
      <amountOfSecuritiesSold>149554</amountOfSecuritiesSold>
      <grossProceeds>276390.75</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/01/2023</saleDate>
      <amountOfSecuritiesSold>192560</amountOfSecuritiesSold>
      <grossProceeds>368783.23</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/03/2023</saleDate>
      <amountOfSecuritiesSold>156383</amountOfSecuritiesSold>
      <grossProceeds>332595.37</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/06/2023</saleDate>
      <amountOfSecuritiesSold>157790</amountOfSecuritiesSold>
      <grossProceeds>312850.24</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/07/2023</saleDate>
      <amountOfSecuritiesSold>151769</amountOfSecuritiesSold>
      <grossProceeds>297664.54</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/08/2023</saleDate>
      <amountOfSecuritiesSold>166514</amountOfSecuritiesSold>
      <grossProceeds>313130.83</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/15/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>67411.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/22/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>61976.16</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>03/01/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>52473.03</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>03/14/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>50058.36</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>03/15/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>49542.96</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>03/22/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>48527.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>01/26/2023</saleDate>
      <amountOfSecuritiesSold>188821</amountOfSecuritiesSold>
      <grossProceeds>333609.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>01/27/2023</saleDate>
      <amountOfSecuritiesSold>145907</amountOfSecuritiesSold>
      <grossProceeds>265769.60</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>01/30/2023</saleDate>
      <amountOfSecuritiesSold>156012</amountOfSecuritiesSold>
      <grossProceeds>294628.66</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>01/31/2023</saleDate>
      <amountOfSecuritiesSold>149554</amountOfSecuritiesSold>
      <grossProceeds>276390.75</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/01/2023</saleDate>
      <amountOfSecuritiesSold>154910</amountOfSecuritiesSold>
      <grossProceeds>296141.45</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/02/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>81616.36</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/03/2023</saleDate>
      <amountOfSecuritiesSold>156382</amountOfSecuritiesSold>
      <grossProceeds>332593.24</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/06/2023</saleDate>
      <amountOfSecuritiesSold>157789</amountOfSecuritiesSold>
      <grossProceeds>312848.25</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/07/2023</saleDate>
      <amountOfSecuritiesSold>151769</amountOfSecuritiesSold>
      <grossProceeds>297664.54</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/08/2023</saleDate>
      <amountOfSecuritiesSold>128864</amountOfSecuritiesSold>
      <grossProceeds>242650.91</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/09/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>68230.91</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/16/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>66798.66</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>02/23/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>60443.88</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>03/14/2023</saleDate>
      <amountOfSecuritiesSold>75300</amountOfSecuritiesSold>
      <grossProceeds>100113.44</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>03/16/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>49510.53</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>03/23/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>47362.61</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>03/29/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>46548.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>03/30/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>46860.68</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>04/05/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>45767.30</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>04/06/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>49320.22</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue 8th Floor</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>04/12/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>49430.86</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue 8th Floor</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ClassA</securitiesClassTitle>
      <saleDate>04/13/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>49895.28</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Reshma Shetty</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>04/19/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>49105.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bartholomew Canton</name>
        <address>
          <com:street1>27 Drydock Avenue</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A</securitiesClassTitle>
      <saleDate>04/20/2023</saleDate>
      <amountOfSecuritiesSold>37650</amountOfSecuritiesSold>
      <grossProceeds>48336.64</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>04/26/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/31/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Lisa Gerard, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Reshma Shetty</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 27573}]
144
0001873523
XXXXXXXX
LIVE
0001830214
Ginkgo Bioworks Holdings, Inc.
001-40097
27 DRYDOCK AVENUE
8TH FLOOR
BOSTON
MA
02210
(877) 442-5362
Shetty Reshma P.
Officer
Director
Class A
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
37650
46309.50
1570064412
04/26/2023
NYSE
Class A
10/13/2022
Restricted Stock Vesting
Issuer
N
37650
10/13/2022
Compensation
N
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
01/26/2023
151171
267285.45
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
01/27/2023
145906
265767.78
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
01/30/2023
156012
294628.66
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
01/31/2023
149554
276390.75
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/01/2023
192560
368783.23
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/03/2023
156383
332595.37
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/06/2023
157790
312850.24
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/07/2023
151769
297664.54
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/08/2023
166514
313130.83
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/15/2023
37650
67411.40
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/22/2023
37650
61976.16
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
03/01/2023
37650
52473.03
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
03/14/2023
37650
50058.36
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
03/15/2023
37650
49542.96
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
03/22/2023
37650
48527.50
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
01/26/2023
188821
333609.40
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
01/27/2023
145907
265769.60
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
01/30/2023
156012
294628.66
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
01/31/2023
149554
276390.75
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/01/2023
154910
296141.45
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/02/2023
37650
81616.36
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/03/2023
156382
332593.24
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/06/2023
157789
312848.25
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/07/2023
151769
297664.54
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/08/2023
128864
242650.91
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/09/2023
37650
68230.91
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/16/2023
37650
66798.66
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
02/23/2023
37650
60443.88
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
03/14/2023
75300
100113.44
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
03/16/2023
37650
49510.53
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
03/23/2023
37650
47362.61
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
03/29/2023
37650
46548.40
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
03/30/2023
37650
46860.68
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
04/05/2023
37650
45767.30
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
04/06/2023
37650
49320.22
Reshma Shetty
27 Drydock Avenue 8th Floor
Boston
MA
02210
Class A
04/12/2023
37650
49430.86
Bartholomew Canton
27 Drydock Avenue 8th Floor
Boston
MA
02210
ClassA
04/13/2023
37650
49895.28
Reshma Shetty
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
04/19/2023
37650
49105.00
Bartholomew Canton
27 Drydock Avenue
8th Floor
Boston
MA
02210
Class A
04/20/2023
37650
48336.64
04/26/2023
08/31/2022
/s/ Lisa Gerard, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Reshma Shetty