<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0002006961</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001571949</issuerCik>
            <issuerName>INTERCONTINENTAL EXCHANGE, INC.</issuerName>
            <secFileNumber>001-36198</secFileNumber>
            <issuerAddress>
                <ns2:street1>5660 New Northside Drive</ns2:street1>
                <ns2:city>Atlanta</ns2:city>
                <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                <ns2:zipCode>30328</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>7708574700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ELIZABETH KING</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>16768</noOfUnitsSold>
            <aggregateMarketValue>2955360.00</aggregateMarketValue>
            <noOfUnitsOutstanding>573626271</noOfUnitsOutstanding>
            <approxSaleDate>05/19/2025</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/19/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10930</amountOfSecuritiesAcquired>
            <paymentDate>05/19/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/30/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>329</amountOfSecuritiesAcquired>
            <paymentDate>06/30/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/05/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5118</amountOfSecuritiesAcquired>
            <paymentDate>02/05/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/03/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>391</amountOfSecuritiesAcquired>
            <paymentDate>12/03/2023</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of an employee stock purchase plan during the period of 06/30/2022 through 03/30/2023.
The securities to be sold were acquired upon the vesting of performance stock units during the period of 02/05/2024 through 02/15/2024.

</remarks>
        <noticeSignature>
            <noticeDate>05/19/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/15/2025</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Elizabeth King</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5382}]
144
0002006961
XXXXXXXX
LIVE
0001571949
INTERCONTINENTAL EXCHANGE, INC.
001-36198
5660 New Northside Drive
Atlanta
GA
30328
7708574700
ELIZABETH KING
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
16768
2955360.00
573626271
05/19/2025
NYSE
Common
05/19/2025
Exercise of Stock Options
Issuer
N
10930
05/19/2025
Cash
Common
06/30/2022
Employee Stock Purchase Plan
Issuer
N
329
06/30/2022
Cash
Common
02/05/2024
Performance Stock Units
Issuer
N
5118
02/05/2024
N/A
Common
12/03/2023
Restricted Stock Units
Issuer
N
391
12/03/2023
N/A
Y
The securities to be sold were acquired upon the vesting of an employee stock purchase plan during the period of 06/30/2022 through 03/30/2023.
The securities to be sold were acquired upon the vesting of performance stock units during the period of 02/05/2024 through 02/15/2024.
05/19/2025
02/15/2025
/s/ Elizabeth King