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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0000914475</issuerCik>
            <issuerName>NEUROCRINE BIOSCIENCES INC</issuerName>
            <secFileNumber>000-22705</secFileNumber>
            <issuerAddress>
                <ns2:street1>12780 El Camino Real </ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92130</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8586177600</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ERIC BENEVICH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2260</noOfUnitsSold>
            <aggregateMarketValue>320151.60</aggregateMarketValue>
            <noOfUnitsOutstanding>98251923</noOfUnitsOutstanding>
            <approxSaleDate>02/06/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/08/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>980</amountOfSecuritiesAcquired>
            <paymentDate>02/08/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/06/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1280</amountOfSecuritiesAcquired>
            <paymentDate>02/06/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for ERIC BENEVICH</name>
                <address>
                    <ns2:street1>12780 El Camino Real </ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>01/31/2024</saleDate>
            <amountOfSecuritiesSold>1207</amountOfSecuritiesSold>
            <grossProceeds>169926.77</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>02/06/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>06/10/2021</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Eric Benevich</signature>
        </noticeSignature>
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144
0001643653
XXXXXXXX
LIVE
0000914475
NEUROCRINE BIOSCIENCES INC
000-22705
12780 El Camino Real
San Diego
CA
92130
8586177600
ERIC BENEVICH
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
2260
320151.60
98251923
02/06/2024
NASDAQ
Common
02/08/2024
Restricted Stock Units
Issuer
N
980
02/08/2024
N/A
Common
02/06/2024
Restricted Stock Units
Issuer
N
1280
02/06/2024
N/A
N
10b5-1 Sales Plan for ERIC BENEVICH
12780 El Camino Real
San Diego
CA
92130
COMMON
01/31/2024
1207
169926.77
02/06/2024
06/10/2021
/s/ Eric Benevich