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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001722067</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001571949</issuerCik>
            <issuerName>INTERCONTINENTAL EXCHANGE, INC.</issuerName>
            <secFileNumber>001-36198</secFileNumber>
            <issuerAddress>
                <ns2:street1>5660 New Northside Drive</ns2:street1>
                <ns2:city>Atlanta</ns2:city>
                <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                <ns2:zipCode>30328</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>7708574700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BENJAMIN JACKSON</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>25004</noOfUnitsSold>
            <aggregateMarketValue>4174667.84</aggregateMarketValue>
            <noOfUnitsOutstanding>574564858</noOfUnitsOutstanding>
            <approxSaleDate>02/20/2025</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/05/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>25004</amountOfSecuritiesAcquired>
            <paymentDate>02/05/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for BENJAMIN JACKSON</name>
                <address>
                    <ns2:street1>5660 New Northside Drive</ns2:street1>
                    <ns2:city>Atlanta</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30328</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>02/18/2025</saleDate>
            <amountOfSecuritiesSold>7900</amountOfSecuritiesSold>
            <grossProceeds>1314272.38</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for BENJAMIN JACKSON</name>
                <address>
                    <ns2:street1>5660 New Northside Drive</ns2:street1>
                    <ns2:city>Atlanta</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30328</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>02/06/2025</saleDate>
            <amountOfSecuritiesSold>5828</amountOfSecuritiesSold>
            <grossProceeds>965774.20</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for BENJAMIN JACKSON</name>
                <address>
                    <ns2:street1>5660 New Northside Drive</ns2:street1>
                    <ns2:city>Atlanta</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30328</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>11/25/2024</saleDate>
            <amountOfSecuritiesSold>5828</amountOfSecuritiesSold>
            <grossProceeds>932480.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of performance stock units during the period of 02/05/2024 through 02/15/2025.
</remarks>
        <noticeSignature>
            <noticeDate>02/20/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/14/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Benjamin Jackson</signature>
        </noticeSignature>
    </formData>
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144
0001722067
XXXXXXXX
LIVE
0001571949
INTERCONTINENTAL EXCHANGE, INC.
001-36198
5660 New Northside Drive
Atlanta
GA
30328
7708574700
BENJAMIN JACKSON
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
25004
4174667.84
574564858
02/20/2025
NYSE
Common
02/05/2024
Performance Stock Units
Issuer
N
25004
02/05/2024
N/A
N
10b5-1 Sales for BENJAMIN JACKSON
5660 New Northside Drive
Atlanta
GA
30328
COMMON
02/18/2025
7900
1314272.38
10b5-1 Sales for BENJAMIN JACKSON
5660 New Northside Drive
Atlanta
GA
30328
COMMON
02/06/2025
5828
965774.20
10b5-1 Sales for BENJAMIN JACKSON
5660 New Northside Drive
Atlanta
GA
30328
COMMON
11/25/2024
5828
932480.00
The securities to be sold were acquired upon the vesting of performance stock units during the period of 02/05/2024 through 02/15/2025.
02/20/2025
08/14/2024
/s/ Benjamin Jackson