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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001214133</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001645569</issuerCik>
            <issuerName>DICE THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-40794</secFileNumber>
            <issuerAddress>
                <ns2:street1>400 EAST JAMIE COURT, SUITE 300</ns2:street1>
                <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 566-1420</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>RICHARD SCHELLER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>84097</noOfUnitsSold>
            <aggregateMarketValue>3238575.47</aggregateMarketValue>
            <noOfUnitsOutstanding>47711123</noOfUnitsOutstanding>
            <approxSaleDate>05/05/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/26/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>11798</amountOfSecuritiesAcquired>
            <paymentDate>03/26/2021</paymentDate>
            <natureOfPayment>None</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/11/2015</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>38400</amountOfSecuritiesAcquired>
            <paymentDate>12/11/2015</paymentDate>
            <natureOfPayment>None</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/01/2018</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>33899</amountOfSecuritiesAcquired>
            <paymentDate>11/01/2018</paymentDate>
            <natureOfPayment>None</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/05/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/11/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Richard Henry Scheller</signature>
        </noticeSignature>
    </formData>
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144
0001214133
XXXXXXXX
LIVE
0001645569
DICE THERAPEUTICS, INC.
001-40794
400 EAST JAMIE COURT, SUITE 300
SOUTH SAN FRANCISCO
CA
94080
(650) 566-1420
RICHARD SCHELLER
Director
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
84097
3238575.47
47711123
05/05/2023
NASDAQ
Common
03/26/2021
Restricted Stock
Issuer
N
11798
03/26/2021
None
Common
12/11/2015
Restricted Stock
Issuer
N
38400
12/11/2015
None
Common
11/01/2018
Restricted Stock
Issuer
N
33899
11/01/2018
None
Y
05/05/2023
11/11/2022
/s/ Richard Henry Scheller