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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001979010</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001503584</issuerCik>
            <issuerName>COSTAMARE INC.</issuerName>
            <secFileNumber>001-34934</secFileNumber>
            <issuerAddress>
                <ns2:street1>Republic of The Marshall Islands</ns2:street1>
                <ns2:city>7 Rue du Gabian</ns2:city>
                <ns2:stateOrCountry>O9</ns2:stateOrCountry>
                <ns2:zipCode>MC 98000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>377-93-25-09-40</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>COSTAMARE SHIPPING COMPANY S.A.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Series E Preferred</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>4011</noOfUnitsSold>
            <aggregateMarketValue>100176.33</aggregateMarketValue>
            <noOfUnitsOutstanding>4574100</noOfUnitsOutstanding>
            <approxSaleDate>06/01/2023</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Series E Preferred</securitiesClassTitle>
            <acquiredDate>01/25/2018</acquiredDate>
            <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Open Market</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>4011</amountOfSecuritiesAcquired>
            <paymentDate>01/25/2018</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>COSTAMARE SHIPPING COMPANY S.A.</name>
                <address>
                    <ns2:street1>Republic of The Marshall Islands</ns2:street1>
                    <ns2:city>7 Rue du Gabian</ns2:city>
                    <ns2:stateOrCountry>O9</ns2:stateOrCountry>
                    <ns2:zipCode>MC 98000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Series E Prefer</securitiesClassTitle>
            <saleDate>05/31/2023</saleDate>
            <amountOfSecuritiesSold>1500</amountOfSecuritiesSold>
            <grossProceeds>37512.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>COSTAMARE SHIPPING COMPANY S.A.</name>
                <address>
                    <ns2:street1>Republic of The Marshall Islands</ns2:street1>
                    <ns2:city>7 Rue du Gabian</ns2:city>
                    <ns2:stateOrCountry>O9</ns2:stateOrCountry>
                    <ns2:zipCode>MC 98000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Series E Prefer</securitiesClassTitle>
            <saleDate>05/30/2023</saleDate>
            <amountOfSecuritiesSold>2549</amountOfSecuritiesSold>
            <grossProceeds>63999.78</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>COSTAMARE SHIPPING COMPANY S.A.</name>
                <address>
                    <ns2:street1>Republic of The Marshall Islands</ns2:street1>
                    <ns2:city>7 Rue du Gabian</ns2:city>
                    <ns2:stateOrCountry>O9</ns2:stateOrCountry>
                    <ns2:zipCode>MC 98000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Series E Prefer</securitiesClassTitle>
            <saleDate>05/26/2023</saleDate>
            <amountOfSecuritiesSold>100</amountOfSecuritiesSold>
            <grossProceeds>2521.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/01/2023</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Konstantinos Konstantakopoulos</signature>
        </noticeSignature>
    </formData>
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144
0001979010
XXXXXXXX
LIVE
0001503584
COSTAMARE INC.
001-34934
Republic of The Marshall Islands
7 Rue du Gabian
O9
MC 98000
377-93-25-09-40
COSTAMARE SHIPPING COMPANY S.A.
Officer
Director
10% Stockholder
Series E Preferred
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
4011
100176.33
4574100
06/01/2023
NYSE
Series E Preferred
01/25/2018
Open Market Purchase
Open Market
N
4011
01/25/2018
Cash
N
COSTAMARE SHIPPING COMPANY S.A.
Republic of The Marshall Islands
7 Rue du Gabian
O9
MC 98000
Series E Prefer
05/31/2023
1500
37512.00
COSTAMARE SHIPPING COMPANY S.A.
Republic of The Marshall Islands
7 Rue du Gabian
O9
MC 98000
Series E Prefer
05/30/2023
2549
63999.78
COSTAMARE SHIPPING COMPANY S.A.
Republic of The Marshall Islands
7 Rue du Gabian
O9
MC 98000
Series E Prefer
05/26/2023
100
2521.00
06/01/2023
/s/ Konstantinos Konstantakopoulos