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    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001842523</cik>
          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>


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    <issuerInfo>
      <issuerCik>0001817229</issuerCik>
      <issuerName>Vor Biopharma Inc.</issuerName>
      <secFileNumber>001-39979</secFileNumber>
      <issuerAddress>
        <com:street1>100 CAMBRIDGEPARK DRIVE</com:street1>
        <com:street2>SUITE 101</com:street2>
        <com:city>CAMBRIDGE</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02140</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>617-655-6580</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jorgensen Nathan D.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Etrade</name>
        <address>
          <com:street1>Harborside 2</com:street1>
          <com:street2>200 Hudson Street, Suite 501</com:street2>
          <com:city>Jersey City</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07311-1113</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>29269</noOfUnitsSold>
      <aggregateMarketValue>27220.17</aggregateMarketValue>
      <noOfUnitsOutstanding>189403</noOfUnitsOutstanding>
      <approxSaleDate>07/03/2024</approxSaleDate>
      <securitiesExchangeName>VOR</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/30/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Primary issuance</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>25735</amountOfSecuritiesAcquired>
      <paymentDate>06/30/2020</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Preferred </securitiesClassTitle>
      <acquiredDate>10/29/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Private Placement Tranche</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Primary Issuance</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1767</amountOfSecuritiesAcquired>
      <paymentDate>10/29/2020</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Preferred</securitiesClassTitle>
      <acquiredDate>01/08/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Private Placement Tranche</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Primary Issuance</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1767</amountOfSecuritiesAcquired>
      <paymentDate>01/08/2021</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Nathan Jorgensen</name>
        <address>
          <com:street1>193 Rice Rd</com:street1>
          <com:city>Wayland</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>01778</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>VOR</securitiesClassTitle>
      <saleDate>05/06/2024</saleDate>
      <amountOfSecuritiesSold>834</amountOfSecuritiesSold>
      <grossProceeds>1459.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>07/19/2024</noticeDate>
      <signature>Nathan Jorgensen</signature>
    </noticeSignature>
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144
0001842523
XXXXXXXX
LIVE
0001817229
Vor Biopharma Inc.
001-39979
100 CAMBRIDGEPARK DRIVE
SUITE 101
CAMBRIDGE
MA
02140
617-655-6580
Jorgensen Nathan D.
Officer
common
Etrade
Harborside 2
200 Hudson Street, Suite 501
Jersey City
NJ
07311-1113
29269
27220.17
189403
07/03/2024
VOR
Common
06/30/2020
Exercise of options under a registered plan
Primary issuance
N
25735
06/30/2020
NA
Preferred
10/29/2020
Private Placement Tranche
Primary Issuance
N
1767
10/29/2020
NA
Preferred
01/08/2021
Private Placement Tranche
Primary Issuance
N
1767
01/08/2021
NA
N
Nathan Jorgensen
193 Rice Rd
Wayland
MA
01778
VOR
05/06/2024
834
1459.50
07/19/2024
Nathan Jorgensen