<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001646649</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001604821</issuerCik>
      <issuerName>Natera, Inc.</issuerName>
      <secFileNumber>001-37478</secFileNumber>
      <issuerAddress>
        <com:street1>13011 MCCALLEN PASS</com:street1>
        <com:street2>BUILDING A SUITE 100</com:street2>
        <com:city>AUSTIN</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>78753</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>650-249-9090</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sheena Jonathan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>3000</noOfUnitsSold>
      <aggregateMarketValue>183000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>120151688</noOfUnitsOutstanding>
      <approxSaleDate>12/28/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/29/2022</acquiredDate>
      <natureOfAcquisitionTransaction>GIFT</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>JONATHAN SHEENA</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>Y</isGiftTransaction>
      <donarAcquiredDate>01/03/2022</donarAcquiredDate>
      <amountOfSecuritiesAcquired>3000</amountOfSecuritiesAcquired>
      <paymentDate>12/29/2022</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Jonathan Sheena</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>10/23/2023</saleDate>
      <amountOfSecuritiesSold>1233</amountOfSecuritiesSold>
      <grossProceeds>49380.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Jonathan Sheena</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass,</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>11/02/2023</saleDate>
      <amountOfSecuritiesSold>6000</amountOfSecuritiesSold>
      <grossProceeds>241501.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Jonathan Sheena</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass,</com:street1>
          <com:street2>Building A Suit 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>12/06/2023</saleDate>
      <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
      <grossProceeds>291078.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Jonathan Sheena</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suit 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>09/28/2023</saleDate>
      <amountOfSecuritiesSold>5448</amountOfSecuritiesSold>
      <grossProceeds>250907.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>This E-file covers the following 2 accounts: SOUTHDAKOTA TRUST COMPANY LLC CARALUNA 1 TRUST (1500 shares) SOUTH DAKOTA TRUST COMPANY LLC CARALUNA 2 TRUST (1500 shares), Jonathan Sheena as Grantor</remarks>
    <noticeSignature>
      <noticeDate>12/28/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>03/08/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>Jonathan Sheena</signature>
    </noticeSignature>
  </formData>
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144
0001646649
XXXXXXXX
LIVE
0001604821
Natera, Inc.
001-37478
13011 MCCALLEN PASS
BUILDING A SUITE 100
AUSTIN
TX
78753
650-249-9090
Sheena Jonathan
Director
Common
Charles Schwab & Co., Inc.
3000 Schwab Way
Westlake
TX
76262
3000
183000.00
120151688
12/28/2023
NASDAQ
Common
12/29/2022
GIFT
JONATHAN SHEENA
Y
01/03/2022
3000
12/29/2022
NA
N
Jonathan Sheena
C/O 13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
COMMON
10/23/2023
1233
49380.00
Jonathan Sheena
C/O 13011 McCallen Pass,
Building A Suite 100
Austin
TX
78753
COMMON
11/02/2023
6000
241501.00
Jonathan Sheena
C/O 13011 McCallen Pass,
Building A Suit 100
Austin
TX
78753
COMMON
12/06/2023
5000
291078.00
Jonathan Sheena
C/O 13011 McCallen Pass
Building A Suit 100
Austin
TX
78753
COMMON
09/28/2023
5448
250907.00
This E-file covers the following 2 accounts: SOUTHDAKOTA TRUST COMPANY LLC CARALUNA 1 TRUST (1500 shares) SOUTH DAKOTA TRUST COMPANY LLC CARALUNA 2 TRUST (1500 shares), Jonathan Sheena as Grantor
12/28/2023
03/08/2023
Jonathan Sheena