<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001186030</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001048695</issuerCik>
      <issuerName>F5, INC.</issuerName>
      <secFileNumber>000-26041</secFileNumber>
      <issuerAddress>
        <com:street1>801 5TH AVENUE</com:street1>
        <com:city>SEATTLE</com:city>
        <com:stateOrCountry>WA</com:stateOrCountry>
        <com:zipCode>98104</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>2062725555</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>HIGGINSON ALAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Affiliate</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schab Corporation</name>
        <address>
          <com:street1>3000 Scwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1000</noOfUnitsSold>
      <aggregateMarketValue>190600.00</aggregateMarketValue>
      <noOfUnitsOutstanding>58806232</noOfUnitsOutstanding>
      <approxSaleDate>03/07/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/11/2009</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4840</amountOfSecuritiesAcquired>
      <paymentDate>03/11/2009</paymentDate>
      <natureOfPayment>Employee Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Alan Higginson co-owner Alan J Higginson &amp; Wendy A Higginson Comm/Prop Account</remarks>
    <noticeSignature>
      <noticeDate>03/07/2024</noticeDate>
      <signature>Alan Higginson</signature>
    </noticeSignature>
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144
0001186030
XXXXXXXX
LIVE
0001048695
F5, INC.
000-26041
801 5TH AVENUE
SEATTLE
WA
98104
2062725555
HIGGINSON ALAN
Affiliate
Common
Charles Schab Corporation
3000 Scwab Way
Westlake
TX
76262
1000
190600.00
58806232
03/07/2024
NASDAQ
Common
03/11/2009
Employee Compensation
Issuer
N
4840
03/11/2009
Employee Compensation
Y
Alan Higginson co-owner Alan J Higginson & Wendy A Higginson Comm/Prop Account
03/07/2024
Alan Higginson