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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001781561</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001321732</issuerCik>
            <issuerName>PENUMBRA, INC.</issuerName>
            <secFileNumber>001-37557</secFileNumber>
            <issuerAddress>
                <ns2:street1>One Penumbra Place</ns2:street1>
                <ns2:city>Alameda</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94502</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 748-3200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SURBHI SARNA</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>85</noOfUnitsSold>
            <aggregateMarketValue>20484.15</aggregateMarketValue>
            <noOfUnitsOutstanding>38436663</noOfUnitsOutstanding>
            <approxSaleDate>10/02/2023</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/30/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>85</amountOfSecuritiesAcquired>
            <paymentDate>09/30/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SURBHI SARNA</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>09/01/2023</saleDate>
            <amountOfSecuritiesSold>85</amountOfSecuritiesSold>
            <grossProceeds>22632.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SURBHI SARNA</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>07/03/2023</saleDate>
            <amountOfSecuritiesSold>27</amountOfSecuritiesSold>
            <grossProceeds>9189.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>10/02/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/18/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Surbini Sarna</signature>
        </noticeSignature>
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144
0001781561
XXXXXXXX
LIVE
0001321732
PENUMBRA, INC.
001-37557
One Penumbra Place
Alameda
CA
94502
(510) 748-3200
SURBHI SARNA
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
85
20484.15
38436663
10/02/2023
NYSE
Common
09/30/2023
Restricted Stock
Issuer
N
85
09/30/2023
Not Applicable
N
SURBHI SARNA
One Penumbra Place
Alameda
CA
94502
common
09/01/2023
85
22632.00
SURBHI SARNA
One Penumbra Place
Alameda
CA
94502
common
07/03/2023
27
9189.00
10/02/2023
05/18/2023
/s/ Surbini Sarna