<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001814883</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
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    <formData>
        <issuerInfo>
            <issuerCik>0001393434</issuerCik>
            <issuerName>OCULAR THERAPEUTIX, INC.</issuerName>
            <secFileNumber>001-36554</secFileNumber>
            <issuerAddress>
                <ns2:street1>24 Crosby Drive</ns2:street1>
                <ns2:city>Bedford</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>01730</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>781-895-3235</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>RABIA OZDEN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>6346</noOfUnitsSold>
            <aggregateMarketValue>30855.10</aggregateMarketValue>
            <noOfUnitsOutstanding>110212114</noOfUnitsOutstanding>
            <approxSaleDate>02/05/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/03/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6346</amountOfSecuritiesAcquired>
            <paymentDate>02/03/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>RABIA OZDEN</name>
                <address>
                    <ns2:street1>24 Crosby Drive</ns2:street1>
                    <ns2:city>Bedford</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>01730</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/31/2024</saleDate>
            <amountOfSecuritiesSold>5360</amountOfSecuritiesSold>
            <grossProceeds>26522.35</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>RABIA OZDEN</name>
                <address>
                    <ns2:street1>24 Crosby Drive</ns2:street1>
                    <ns2:city>Bedford</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>01730</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/31/2024</saleDate>
            <amountOfSecuritiesSold>2404</amountOfSecuritiesSold>
            <grossProceeds>11894.75</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>02/05/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Rabia Ozden</signature>
        </noticeSignature>
    </formData>
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144
0001814883
XXXXXXXX
LIVE
0001393434
OCULAR THERAPEUTIX, INC.
001-36554
24 Crosby Drive
Bedford
MA
01730
781-895-3235
RABIA OZDEN
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
6346
30855.10
110212114
02/05/2024
NASDAQ
Common
02/03/2024
Restricted stock vesting under a registered plan
Issuer
N
6346
02/03/2024
Not Applicable
N
RABIA OZDEN
24 Crosby Drive
Bedford
MA
01730
Common
01/31/2024
5360
26522.35
RABIA OZDEN
24 Crosby Drive
Bedford
MA
01730
Common
01/31/2024
2404
11894.75
02/05/2024
/s/ Rabia Ozden