<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001711968</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001604821</issuerCik>
            <issuerName>NATERA, INC.</issuerName>
            <secFileNumber>001-37478</secFileNumber>
            <issuerAddress>
                <ns2:street1>13011 McCallen Pass</ns2:street1>
                <ns2:street2>Building A Suite 100</ns2:street2>
                <ns2:city>Austin</ns2:city>
                <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                <ns2:zipCode>78753</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 980-9190</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEVEN L CHAPMAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>15898</noOfUnitsSold>
            <aggregateMarketValue>2233330.11</aggregateMarketValue>
            <noOfUnitsOutstanding>135186184</noOfUnitsOutstanding>
            <approxSaleDate>04/01/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/21/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>15898</amountOfSecuritiesAcquired>
            <paymentDate>01/21/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/31/2025</saleDate>
            <amountOfSecuritiesSold>9563</amountOfSecuritiesSold>
            <grossProceeds>1323617.07</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/17/2025</saleDate>
            <amountOfSecuritiesSold>6702</amountOfSecuritiesSold>
            <grossProceeds>978677.65</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/05/2025</saleDate>
            <amountOfSecuritiesSold>7666</amountOfSecuritiesSold>
            <grossProceeds>1099486.85</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/05/2025</saleDate>
            <amountOfSecuritiesSold>51711</amountOfSecuritiesSold>
            <grossProceeds>7415507.36</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/05/2025</saleDate>
            <amountOfSecuritiesSold>27895</amountOfSecuritiesSold>
            <grossProceeds>4000006.31</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/29/2025</saleDate>
            <amountOfSecuritiesSold>13685</amountOfSecuritiesSold>
            <grossProceeds>2269928.10</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/22/2025</saleDate>
            <amountOfSecuritiesSold>78553</amountOfSecuritiesSold>
            <grossProceeds>12958585.04</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of Restricted Stock during the period of 01/21/2022 through 03/28/2025.</remarks>
        <noticeSignature>
            <noticeDate>04/01/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/02/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Steven Leonard Chapman</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 8931}]
144
0001711968
XXXXXXXX
LIVE
0001604821
NATERA, INC.
001-37478
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
(650) 980-9190
STEVEN L CHAPMAN
Officer
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
15898
2233330.11
135186184
04/01/2025
NASDAQ
Common
01/21/2022
Restricted Stock
Issuer
N
15898
01/21/2022
Not Applicable
N
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
03/31/2025
9563
1323617.07
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
03/17/2025
6702
978677.65
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
03/05/2025
7666
1099486.85
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
03/05/2025
51711
7415507.36
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
03/05/2025
27895
4000006.31
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
01/29/2025
13685
2269928.10
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
01/22/2025
78553
12958585.04
The securities to be sold were acquired upon the vesting of Restricted Stock during the period of 01/21/2022 through 03/28/2025.
04/01/2025
12/02/2024
/s/ Steven Leonard Chapman