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                <ns2:street2>Suite 703</ns2:street2>
                <ns2:city>Boston</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02116</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>617-468-4219</issuerContactPhone>
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            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
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            <securitiesClassTitle>Common</securitiesClassTitle>
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                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
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            <noOfUnitsSold>79146</noOfUnitsSold>
            <aggregateMarketValue>1056599.10</aggregateMarketValue>
            <noOfUnitsOutstanding>54415619</noOfUnitsOutstanding>
            <approxSaleDate>03/14/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <acquiredDate>03/14/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>79146</amountOfSecuritiesAcquired>
            <paymentDate>03/14/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>03/14/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/13/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Lara S Meisner</signature>
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144
0001883986
XXXXXXXX
LIVE
0002023658
BICARA THERAPEUTICS INC
001-42271
116 Huntington Ave
Suite 703
Boston
MA
02116
617-468-4219
LARA S. MEISNER
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
79146
1056599.10
54415619
03/14/2025
NASDAQ
Common
03/14/2025
Exercise of Stock Options
Issuer
N
79146
03/14/2025
Cash
Y
03/14/2025
11/13/2024
/s/ Lara S Meisner