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            <filer>
                <filerCredentials>
                    <cik>0001969082</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001628171</issuerCik>
            <issuerName>REVOLUTION MEDICINES INC</issuerName>
            <secFileNumber>001-39219</secFileNumber>
            <issuerAddress>
                <ns2:street1>700 Saginaw Drive </ns2:street1>
                <ns2:city>Redwood</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94063</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6504816801</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JEFFREY CISLINI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2000</noOfUnitsSold>
            <aggregateMarketValue>57800.00</aggregateMarketValue>
            <noOfUnitsOutstanding>109169897</noOfUnitsOutstanding>
            <approxSaleDate>09/28/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/15/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2000</amountOfSecuritiesAcquired>
            <paymentDate>12/15/2022</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JEFFREY TODD CISLINI</name>
                <address>
                    <ns2:street1>700 Saginaw Drive </ns2:street1>
                    <ns2:city>Redwood</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/31/2023</saleDate>
            <amountOfSecuritiesSold>1500</amountOfSecuritiesSold>
            <grossProceeds>39030.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>09/28/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/27/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jeffrey Cislini</signature>
        </noticeSignature>
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144
0001969082
XXXXXXXX
LIVE
0001628171
REVOLUTION MEDICINES INC
001-39219
700 Saginaw Drive
Redwood
CA
94063
6504816801
JEFFREY CISLINI
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
2000
57800.00
109169897
09/28/2023
NASDAQ
Common
12/15/2022
Restricted Stock Units
Issuer
N
2000
12/15/2022
N/A
N
10b5-1 Sales for JEFFREY TODD CISLINI
700 Saginaw Drive
Redwood
CA
94063
Common
07/31/2023
1500
39030.00
09/28/2023
03/27/2023
/s/ Jeffrey Cislini