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            <secFileNumber>001-32295</secFileNumber>
            <issuerAddress>
                <ns2:street1>PO BOX 13628, 68 TW ALEXANDER DRIVE</ns2:street1>
                <ns2:city>Research Triangle Park</ns2:city>
                <ns2:stateOrCountry>NC</ns2:stateOrCountry>
                <ns2:zipCode>27709</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(919) 636-4530</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROSTISLAV RAYKOV</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2431</noOfUnitsSold>
            <aggregateMarketValue>10477.61</aggregateMarketValue>
            <noOfUnitsOutstanding>27364335</noOfUnitsOutstanding>
            <approxSaleDate>11/04/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>10/31/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2431</amountOfSecuritiesAcquired>
            <paymentDate>10/31/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
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                <address>
                    <ns2:street1>PO BOX 13628, 68 TW ALEXANDER DRIVE</ns2:street1>
                    <ns2:city>Research Triangle Park</ns2:city>
                    <ns2:stateOrCountry>NC</ns2:stateOrCountry>
                    <ns2:zipCode>27709</ns2:zipCode>
                </address>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/01/2024</saleDate>
            <amountOfSecuritiesSold>2431</amountOfSecuritiesSold>
            <grossProceeds>12009.14</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROSTISLAV RAYKOV</name>
                <address>
                    <ns2:street1>PO BOX 13628, 68 TW ALEXANDER DRIVE</ns2:street1>
                    <ns2:city>Research Triangle Park</ns2:city>
                    <ns2:stateOrCountry>NC</ns2:stateOrCountry>
                    <ns2:zipCode>27709</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/04/2024</saleDate>
            <amountOfSecuritiesSold>2431</amountOfSecuritiesSold>
            <grossProceeds>13419.12</grossProceeds>
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        <noticeSignature>
            <noticeDate>11/04/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/14/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Rostislav Raykov</signature>
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144
0001468316
XXXXXXXX
LIVE
0001211583
FENNEC PHARMACEUTICALS INC.
001-32295
PO BOX 13628, 68 TW ALEXANDER DRIVE
Research Triangle Park
NC
27709
(919) 636-4530
ROSTISLAV RAYKOV
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
2431
10477.61
27364335
11/04/2024
NASDAQ
COMMON
10/31/2024
Restricted Stock
ISSUER
N
2431
10/31/2024
Not Applicable
N
ROSTISLAV RAYKOV
PO BOX 13628, 68 TW ALEXANDER DRIVE
Research Triangle Park
NC
27709
Common
10/01/2024
2431
12009.14
ROSTISLAV RAYKOV
PO BOX 13628, 68 TW ALEXANDER DRIVE
Research Triangle Park
NC
27709
Common
09/04/2024
2431
13419.12
11/04/2024
12/14/2023
/s/ Rostislav Raykov