<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001611311</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001437402</issuerCik>
            <issuerName>ARDELYX, INC.</issuerName>
            <secFileNumber>001-36485</secFileNumber>
            <issuerAddress>
                <ns2:street1>400 Fifth Avenue Suite 210</ns2:street1>
                <ns2:street2>Suite 210</ns2:street2>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02451</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>5107451700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>DAVID P ROSENBAUM </nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>110000</noOfUnitsSold>
            <aggregateMarketValue>588500.00</aggregateMarketValue>
            <noOfUnitsOutstanding>236854270</noOfUnitsOutstanding>
            <approxSaleDate>01/16/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/16/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>60000</amountOfSecuritiesAcquired>
            <paymentDate>01/16/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/01/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
            <paymentDate>06/01/2022</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>DAVID P ROSENBAUM</name>
                <address>
                    <ns2:street1>400 Fifth Avenue</ns2:street1>
                    <ns2:street2>Suite 210</ns2:street2>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/20/2024</saleDate>
            <amountOfSecuritiesSold>7184</amountOfSecuritiesSold>
            <grossProceeds>34443.69</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>DAVID P ROSENBAUM</name>
                <address>
                    <ns2:street1>400 Fifth Avenue</ns2:street1>
                    <ns2:street2>Suite 210</ns2:street2>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/06/2024</saleDate>
            <amountOfSecuritiesSold>27171</amountOfSecuritiesSold>
            <grossProceeds>165743.10</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>DAVID P ROSENBAUM</name>
                <address>
                    <ns2:street1>400 Fifth Avenue</ns2:street1>
                    <ns2:street2>Suite 210</ns2:street2>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/04/2024</saleDate>
            <amountOfSecuritiesSold>27172</amountOfSecuritiesSold>
            <grossProceeds>161673.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 06/01/2022 through 02/19/2023.
</remarks>
        <noticeSignature>
            <noticeDate>01/16/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/17/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ David Paul Rosenbaum</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001611311
XXXXXXXX
LIVE
0001437402
ARDELYX, INC.
001-36485
400 Fifth Avenue Suite 210
Suite 210
Waltham
MA
02451
5107451700
DAVID P ROSENBAUM
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
110000
588500.00
236854270
01/16/2025
NASDAQ
Common
01/16/2025
Exercise of Stock Options
Issuer
N
60000
01/16/2025
Cash
Common
06/01/2022
Restricted Stock Units
Issuer
N
50000
06/01/2022
N/A
N
DAVID P ROSENBAUM
400 Fifth Avenue
Suite 210
Waltham
MA
02451
Common
11/20/2024
7184
34443.69
DAVID P ROSENBAUM
400 Fifth Avenue
Suite 210
Waltham
MA
02451
Common
11/06/2024
27171
165743.10
DAVID P ROSENBAUM
400 Fifth Avenue
Suite 210
Waltham
MA
02451
Common
11/04/2024
27172
161673.40
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 06/01/2022 through 02/19/2023.
01/16/2025
05/17/2024
/s/ David Paul Rosenbaum