<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001966716</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001623526</issuerCik>
            <issuerName>STOKE THERAPEUTICS INC</issuerName>
            <secFileNumber>001-38938</secFileNumber>
            <issuerAddress>
                <ns2:street1>45 Wiggins Ave</ns2:street1>
                <ns2:city>Bedford</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>01730</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>7814308200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JONATHAN ALLAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>1948</noOfUnitsSold>
            <aggregateMarketValue>26921.36</aggregateMarketValue>
            <noOfUnitsOutstanding>44188534</noOfUnitsOutstanding>
            <approxSaleDate>06/21/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/31/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1948</amountOfSecuritiesAcquired>
            <paymentDate>12/31/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/21/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/22/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jonathan Allen</signature>
        </noticeSignature>
    </formData>
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144
0001966716
XXXXXXXX
LIVE
0001623526
STOKE THERAPEUTICS INC
001-38938
45 Wiggins Ave
Bedford
MA
01730
7814308200
JONATHAN ALLAN
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
1948
26921.36
44188534
06/21/2023
NASDAQ
Common
12/31/2022
Employee Stock Purchase Plan
Issuer
N
1948
12/31/2022
Cash
Y
06/21/2023
03/22/2023
/s/ Jonathan Allen