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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>001-40627</secFileNumber>
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                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41216941060</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ZHENYU XU</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>12000</noOfUnitsSold>
            <aggregateMarketValue>57600.00</aggregateMarketValue>
            <noOfUnitsOutstanding>65230559</noOfUnitsOutstanding>
            <approxSaleDate>06/13/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/20/2012</acquiredDate>
            <natureOfAcquisitionTransaction>Founders Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>12000</amountOfSecuritiesAcquired>
            <paymentDate>06/20/2012</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>05/29/2024</saleDate>
            <amountOfSecuritiesSold>20000</amountOfSecuritiesSold>
            <grossProceeds>113484.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
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                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/20/2024</saleDate>
            <amountOfSecuritiesSold>758</amountOfSecuritiesSold>
            <grossProceeds>3441.32</grossProceeds>
        </securitiesSoldInPast3Months>
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                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>05/13/2024</saleDate>
            <amountOfSecuritiesSold>4000</amountOfSecuritiesSold>
            <grossProceeds>18590.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
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                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>04/15/2024</saleDate>
            <amountOfSecuritiesSold>4000</amountOfSecuritiesSold>
            <grossProceeds>19432.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
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                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
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            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>03/14/2024</saleDate>
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            <grossProceeds>16932.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/13/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/14/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Zhenyu Xu</signature>
        </noticeSignature>
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144
0002006362
XXXXXXXX
LIVE
0001840706
SOPHIA GENETICS SA
001-40627
La Piece 12 ch-1180
Rolle
V8
00000
41216941060
ZHENYU XU
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
12000
57600.00
65230559
06/13/2024
NASDAQ
Common
06/20/2012
Founders Shares
Issuer
N
12000
06/20/2012
N/A
N
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
COMMON
05/29/2024
20000
113484.00
ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
05/20/2024
758
3441.32
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
COMMON
05/13/2024
4000
18590.40
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
COMMON
04/15/2024
4000
19432.00
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
COMMON
03/14/2024
4000
16932.00
06/13/2024
12/14/2023
/s/ Zhenyu Xu