<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001218802</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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    <formData>
        <issuerInfo>
            <issuerCik>0001459839</issuerCik>
            <issuerName>SI-BONE, Inc.</issuerName>
            <secFileNumber>001-38701</secFileNumber>
            <issuerAddress>
                <ns2:street1>471 El Camino Real, Suite 101</ns2:street1>
                <ns2:city>Santa Clara</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>95050</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>4082070700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>DAVID &amp; LAURA FRANCIS JOINT REV TRU/A DTD 01/03/2003</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>38504</noOfUnitsSold>
            <aggregateMarketValue>633390.80</aggregateMarketValue>
            <noOfUnitsOutstanding>42614514</noOfUnitsOutstanding>
            <approxSaleDate>05/07/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/01/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7303</amountOfSecuritiesAcquired>
            <paymentDate>01/01/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/15/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>31201</amountOfSecuritiesAcquired>
            <paymentDate>02/15/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>DAVID &amp; LAURA FRANCIS JOINT REV TRU/A DTD 01/03/2003</name>
                <address>
                    <ns2:street1>471 El Camino Real, Suite 101</ns2:street1>
                    <ns2:city>Santa Clara</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95050</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/18/2025</saleDate>
            <amountOfSecuritiesSold>46233</amountOfSecuritiesSold>
            <grossProceeds>795914.58</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 1/15/25 through 2/15/25
</remarks>
        <noticeSignature>
            <noticeDate>05/07/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/13/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Laura Francis</signature>
        </noticeSignature>
    </formData>
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144
0001218802
XXXXXXXX
LIVE
0001459839
SI-BONE, Inc.
001-38701
471 El Camino Real, Suite 101
Santa Clara
CA
95050
4082070700
DAVID & LAURA FRANCIS JOINT REV TRU/A DTD 01/03/2003
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
38504
633390.80
42614514
05/07/2025
NASDAQ
Common
01/01/2025
Restricted Stock Units
Issuer
N
7303
01/01/2025
N/A
Common
02/15/2025
Performance Stock Units
Issuer
N
31201
02/15/2025
N/A
N
DAVID & LAURA FRANCIS JOINT REV TRU/A DTD 01/03/2003
471 El Camino Real, Suite 101
Santa Clara
CA
95050
Common
02/18/2025
46233
795914.58
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 1/15/25 through 2/15/25
05/07/2025
12/13/2024
/s/ Laura Francis