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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001522780</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001623526</issuerCik>
            <issuerName>STOKE THERAPEUTICS INC</issuerName>
            <secFileNumber>001-38938</secFileNumber>
            <issuerAddress>
                <ns2:street1>45 Wiggins Ave</ns2:street1>
                <ns2:city>Bedford</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>01730</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>7814308200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>EDWARD M KAYE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>42350</noOfUnitsSold>
            <aggregateMarketValue>588665.00</aggregateMarketValue>
            <noOfUnitsOutstanding>52119860</noOfUnitsOutstanding>
            <approxSaleDate>05/20/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/25/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Previously Exercised Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>8000</amountOfSecuritiesAcquired>
            <paymentDate>05/25/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/15/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>24350</amountOfSecuritiesAcquired>
            <paymentDate>03/15/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/30/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Previously Exercised Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
            <paymentDate>12/30/2020</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/20/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/26/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Edward Michael Kaye</signature>
        </noticeSignature>
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144
0001522780
XXXXXXXX
LIVE
0001623526
STOKE THERAPEUTICS INC
001-38938
45 Wiggins Ave
Bedford
MA
01730
7814308200
EDWARD M KAYE
Director
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
42350
588665.00
52119860
05/20/2024
NASDAQ
Common
05/25/2022
Previously Exercised Stock Options
Issuer
N
8000
05/25/2022
Cash
Common
03/15/2024
Restricted Stock Units
Issuer
N
24350
03/15/2024
N/A
Common
12/30/2020
Previously Exercised Stock Options
Issuer
N
10000
12/30/2020
Cash
Y
05/20/2024
12/26/2023
/s/ Edward Michael Kaye