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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001599901</issuerCik>
            <issuerName>AVIDITY BIOSCIENCES INC</issuerName>
            <secFileNumber>001-39321</secFileNumber>
            <issuerAddress>
                <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92121</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8584017900</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SARAH BOYCE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>84000</noOfUnitsSold>
            <aggregateMarketValue>2260440.00</aggregateMarketValue>
            <noOfUnitsOutstanding>95636748</noOfUnitsOutstanding>
            <approxSaleDate>06/04/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/04/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>84000</amountOfSecuritiesAcquired>
            <paymentDate>06/04/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for SARAH BOYCE</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/07/2024</saleDate>
            <amountOfSecuritiesSold>28000</amountOfSecuritiesSold>
            <grossProceeds>715050.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for SARAH BOYCE</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/02/2024</saleDate>
            <amountOfSecuritiesSold>28000</amountOfSecuritiesSold>
            <grossProceeds>734918.80</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for SARAH BOYCE</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/12/2024</saleDate>
            <amountOfSecuritiesSold>28000</amountOfSecuritiesSold>
            <grossProceeds>633682.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for SARAH BOYCE</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/08/2024</saleDate>
            <amountOfSecuritiesSold>84000</amountOfSecuritiesSold>
            <grossProceeds>1796712.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months.&#13;
The date of acquisition and payment was and will be the date of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>06/04/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>06/09/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Sarah Boyce</signature>
        </noticeSignature>
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144
0001629383
XXXXXXXX
LIVE
0001599901
AVIDITY BIOSCIENCES INC
001-39321
10578 Science Center Drive, Suite 125
San Diego
CA
92121
8584017900
SARAH BOYCE
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
84000
2260440.00
95636748
06/04/2024
NASDAQ
Common
06/04/2024
Exercise of Stock Options
Issuer
N
84000
06/04/2024
Cash
N
10b5-1 Sales for SARAH BOYCE
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
05/07/2024
28000
715050.00
10b5-1 Sales for SARAH BOYCE
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
04/02/2024
28000
734918.80
10b5-1 Sales for SARAH BOYCE
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
03/12/2024
28000
633682.00
10b5-1 Sales for SARAH BOYCE
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
03/08/2024
84000
1796712.40
The securities to be sold were and will be received upon the exercise of stock options over the next three months.
The date of acquisition and payment was and will be the date of exercise/sale.
06/04/2024
06/09/2023
/s/ Sarah Boyce