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    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001247024</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001863127</issuerCik>
            <issuerName>TYRA BIOSCIENCES, INC.</issuerName>
            <secFileNumber>001-40800</secFileNumber>
      <issuerAddress>
                <ns2:street1>2656 State Street</ns2:street1>
                <ns2:city>Carlsbad</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92008</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(619) 728-4760</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>GILLA KAPLAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>10</noOfUnitsSold>
            <aggregateMarketValue>103.50</aggregateMarketValue>
            <noOfUnitsOutstanding>53177990</noOfUnitsOutstanding>
            <approxSaleDate>06/17/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/13/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10</amountOfSecuritiesAcquired>
            <paymentDate>06/13/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>GILLA KAPLAN</name>
                <address>
                    <ns2:street1>2656 State Street</ns2:street1>
                    <ns2:city>Carlsbad</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92008</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/16/2025</saleDate>
            <amountOfSecuritiesSold>6814</amountOfSecuritiesSold>
            <grossProceeds>70725.91</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>GILLA KAPLAN</name>
                <address>
                    <ns2:street1>2656 State Street</ns2:street1>
                    <ns2:city>Carlsbad</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92008</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2025</saleDate>
            <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
            <grossProceeds>154582.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>GILLA KAPLAN</name>
                <address>
                    <ns2:street1>2656 State Street</ns2:street1>
                    <ns2:city>Carlsbad</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92008</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/12/2025</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>104227.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>GILLA KAPLAN</name>
                <address>
                    <ns2:street1>2656 State Street</ns2:street1>
                    <ns2:city>Carlsbad</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92008</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/12/2025</saleDate>
            <amountOfSecuritiesSold>20000</amountOfSecuritiesSold>
            <grossProceeds>205028.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/17/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Gilla Kaplan</signature>
        </noticeSignature>
    </formData>
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144
0001247024
XXXXXXXX
LIVE
0001863127
TYRA BIOSCIENCES, INC.
001-40800
2656 State Street
Carlsbad
CA
92008
(619) 728-4760
GILLA KAPLAN
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
10
103.50
53177990
06/17/2025
NASDAQ
Common
06/13/2024
Exercise of options under a registered plan
Issuer
N
10
06/13/2024
Cash
N
GILLA KAPLAN
2656 State Street
Carlsbad
CA
92008
Common
06/16/2025
6814
70725.91
GILLA KAPLAN
2656 State Street
Carlsbad
CA
92008
Common
06/13/2025
15000
154582.50
GILLA KAPLAN
2656 State Street
Carlsbad
CA
92008
Common
06/12/2025
10000
104227.00
GILLA KAPLAN
2656 State Street
Carlsbad
CA
92008
Common
06/12/2025
20000
205028.00
06/17/2025
/s/ Gilla Kaplan