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      <liveTestFlag>LIVE</liveTestFlag>



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    <issuerInfo>
      <issuerCik>0001048695</issuerCik>
      <issuerName>F5, INC.</issuerName>
      <secFileNumber>000-26041</secFileNumber>
      <issuerAddress>
        <com:street1>801 5TH AVENUE</com:street1>
        <com:city>SEATTLE</com:city>
        <com:stateOrCountry>WA</com:stateOrCountry>
        <com:zipCode>98104</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>2062725555</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Dreyer Michael L</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab Corporation</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2250</noOfUnitsSold>
      <aggregateMarketValue>380250.00</aggregateMarketValue>
      <noOfUnitsOutstanding>58611430</noOfUnitsOutstanding>
      <approxSaleDate>05/29/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/01/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2250</amountOfSecuritiesAcquired>
      <paymentDate>01/01/2020</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>2a) The Michael L. &amp; Amy S. Dreyer Trust 8/28/2009, Michael &amp; Amy Dreyer TTEES

2,250 shares to be sold were acquired between 01/01/2020 - 12/31/2021 via Restricted Stock Units</remarks>
    <noticeSignature>
      <noticeDate>05/29/2024</noticeDate>
      <signature>Michael Lewis Dreyer TTEE for The Michael L. &amp; Amy S. Dreyer Trust 8/28/2009</signature>
    </noticeSignature>
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144
0001560297
XXXXXXXX
LIVE
0001048695
F5, INC.
000-26041
801 5TH AVENUE
SEATTLE
WA
98104
2062725555
Dreyer Michael L
Director
Common
Charles Schwab Corporation
3000 Schwab Way
Westlake
TX
76262
2250
380250.00
58611430
05/29/2024
NASDAQ
Common
01/01/2020
Restricted Stock Units
Issuer
N
2250
01/01/2020
Equity Compensation
Y
2a) The Michael L. & Amy S. Dreyer Trust 8/28/2009, Michael & Amy Dreyer TTEES

2,250 shares to be sold were acquired between 01/01/2020 - 12/31/2021 via Restricted Stock Units
05/29/2024
Michael Lewis Dreyer TTEE for The Michael L. & Amy S. Dreyer Trust 8/28/2009