<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001856304</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
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    <formData>
        <issuerInfo>
            <issuerCik>0001816017</issuerCik>
            <issuerName>SPIRE GLOBAL, INC.</issuerName>
            <secFileNumber>001-39493</secFileNumber>
            <issuerAddress>
                <ns2:street1>8000 Towers Crescent Drive  Suite 1100</ns2:street1>
                <ns2:city>Vienna,</ns2:city>
                <ns2:stateOrCountry>VA</ns2:stateOrCountry>
                <ns2:zipCode>22182</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(202) 301-5127</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEPHEN D MESSER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>16661</noOfUnitsSold>
            <aggregateMarketValue>180840.16</aggregateMarketValue>
            <noOfUnitsOutstanding>32583984</noOfUnitsOutstanding>
            <approxSaleDate>06/13/2025</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/02/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>12572</amountOfSecuritiesAcquired>
            <paymentDate>06/02/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/16/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>4089</amountOfSecuritiesAcquired>
            <paymentDate>08/16/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/13/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Stephen Dale Messer</signature>
        </noticeSignature>
    </formData>
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144
0001856304
XXXXXXXX
LIVE
0001816017
SPIRE GLOBAL, INC.
001-39493
8000 Towers Crescent Drive  Suite 1100
Vienna,
VA
22182
(202) 301-5127
STEPHEN D MESSER
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
16661
180840.16
32583984
06/13/2025
NYSE
Common
06/02/2023
Restricted Stock
Issuer
N
12572
06/02/2023
Not Applicable
Common
08/16/2022
Restricted Stock
Issuer
N
4089
08/16/2022
Not Applicable
Y
06/13/2025
/s/ Stephen Dale Messer