<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001666236</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001714899</issuerCik>
            <issuerName>DENALI THERAPEUTICS INC</issuerName>
            <secFileNumber>001-38311</secFileNumber>
            <issuerAddress>
                <ns2:street1>161 Oyster Point Blvd.</ns2:street1>
                <ns2:city>South San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6508668548</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEVE KROGNES</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>30000</noOfUnitsSold>
            <aggregateMarketValue>882900.00</aggregateMarketValue>
            <noOfUnitsOutstanding>143165264</noOfUnitsOutstanding>
            <approxSaleDate>09/30/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>07/19/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Previously Exercised Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>30000</amountOfSecuritiesAcquired>
            <paymentDate>07/19/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVE EDWARD KROGNES</name>
                <address>
                    <ns2:street1>161 Oyster Point Blvd.</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/20/2024</saleDate>
            <amountOfSecuritiesSold>1727</amountOfSecuritiesSold>
            <grossProceeds>41085.33</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for STEVE EDWARD KROGNES</name>
                <address>
                    <ns2:street1>161 Oyster Point Blvd.</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/01/2024</saleDate>
            <amountOfSecuritiesSold>30000</amountOfSecuritiesSold>
            <grossProceeds>663684.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>09/30/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/01/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Steve Krognes</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4764}]
144
0001666236
XXXXXXXX
LIVE
0001714899
DENALI THERAPEUTICS INC
001-38311
161 Oyster Point Blvd.
South San Francisco
CA
94080
6508668548
STEVE KROGNES
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
30000
882900.00
143165264
09/30/2024
NASDAQ
Common
07/19/2022
Previously Exercised Options
Issuer
N
30000
07/19/2022
Cash
N
STEVE EDWARD KROGNES
161 Oyster Point Blvd.
South San Francisco
CA
94080
Common
08/20/2024
1727
41085.33
10b5-1 Sales for STEVE EDWARD KROGNES
161 Oyster Point Blvd.
South San Francisco
CA
94080
Common
07/01/2024
30000
663684.00
09/30/2024
12/01/2023
/s/ Steve Krognes