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    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001418975</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001324404</issuerCik>
      <issuerName>CF Industries Holdings, Inc.</issuerName>
      <secFileNumber>001-32597</secFileNumber>
      <issuerAddress>
        <com:street1>2375 WATERVIEW DRIVE</com:street1>
        <com:city>NORTHBROOK</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60062</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(847) 405-2400</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Hoker Richard A</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>11029</noOfUnitsSold>
      <aggregateMarketValue>927611.00</aggregateMarketValue>
      <noOfUnitsOutstanding>188337896</noOfUnitsOutstanding>
      <approxSaleDate>03/14/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/02/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CF INDUSTRIES HOLDINGS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1452</amountOfSecuritiesAcquired>
      <paymentDate>01/02/2022</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/04/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CF INDUSTRIES HOLDINGS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1015</amountOfSecuritiesAcquired>
      <paymentDate>01/04/2022</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/02/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CF INDUSTRIES HOLDINGS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>688</amountOfSecuritiesAcquired>
      <paymentDate>01/02/2023</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/04/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CF INDUSTRIES HOLDINGS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1541</amountOfSecuritiesAcquired>
      <paymentDate>01/04/2023</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/28/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Performance Award Lapse</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CF INDUSTRIES HOLDINGS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6333</amountOfSecuritiesAcquired>
      <paymentDate>02/28/2023</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Shares sold in RICHARD A HOKER REVOCABLE TRUST account.</remarks>
    <noticeSignature>
      <noticeDate>03/14/2024</noticeDate>
      <signature>Richard A Hoker TTEE</signature>
    </noticeSignature>
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144
0001418975
XXXXXXXX
LIVE
0001324404
CF Industries Holdings, Inc.
001-32597
2375 WATERVIEW DRIVE
NORTHBROOK
IL
60062
(847) 405-2400
Hoker Richard A
Officer
Common
Charles Schwab & Co., Inc.
3000 Schwab Way
Westlake
TX
76262
11029
927611.00
188337896
03/14/2024
NYSE
Common
01/02/2022
Restricted Stock Lapse
CF INDUSTRIES HOLDINGS, INC.
N
1452
01/02/2022
Equity Compensation
Common
01/04/2022
Restricted Stock Lapse
CF INDUSTRIES HOLDINGS, INC.
N
1015
01/04/2022
Equity Compensation
Common
01/02/2023
Restricted Stock Lapse
CF INDUSTRIES HOLDINGS, INC.
N
688
01/02/2023
Equity Compensation
Common
01/04/2023
Restricted Stock Lapse
CF INDUSTRIES HOLDINGS, INC.
N
1541
01/04/2023
Equity Compensation
Common
02/28/2023
Performance Award Lapse
CF INDUSTRIES HOLDINGS, INC.
N
6333
02/28/2023
Equity Compensation
Y
Shares sold in RICHARD A HOKER REVOCABLE TRUST account.
03/14/2024
Richard A Hoker TTEE