<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001254781</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001107843</issuerCik>
            <issuerName>QUALYS, INC.</issuerName>
            <secFileNumber>001-35662</secFileNumber>
            <issuerAddress>
                <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                <ns2:city> Foster City</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94404</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6508016100</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BRUCE POSEY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>3999</noOfUnitsSold>
            <aggregateMarketValue>494396.37</aggregateMarketValue>
            <noOfUnitsOutstanding>36811018</noOfUnitsOutstanding>
            <approxSaleDate>08/20/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/01/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>999</amountOfSecuritiesAcquired>
            <paymentDate>08/01/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/20/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3000</amountOfSecuritiesAcquired>
            <paymentDate>08/20/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for BRUCE K. POSEY</name>
                <address>
                    <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                    <ns2:city> Foster City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94404</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/22/2024</saleDate>
            <amountOfSecuritiesSold>1339</amountOfSecuritiesSold>
            <grossProceeds>191941.47</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for BRUCE K. POSEY</name>
                <address>
                    <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                    <ns2:city> Foster City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94404</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/20/2024</saleDate>
            <amountOfSecuritiesSold>1330</amountOfSecuritiesSold>
            <grossProceeds>179740.75</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>08/20/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/28/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Bruce K. Posey</signature>
        </noticeSignature>
    </formData>
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144
0001254781
XXXXXXXX
LIVE
0001107843
QUALYS, INC.
001-35662
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
6508016100
BRUCE POSEY
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
3999
494396.37
36811018
08/20/2024
NASDAQ
Common
08/01/2024
Restricted Stock Units
Issuer
N
999
08/01/2024
N/A
Common
08/20/2024
Exercise of Stock Options
Issuer
N
3000
08/20/2024
Cash
N
10b5-1 Sales Plan for BRUCE K. POSEY
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
Common
07/22/2024
1339
191941.47
10b5-1 Sales Plan for BRUCE K. POSEY
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
Common
06/20/2024
1330
179740.75
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
08/20/2024
08/28/2023
/s/ Bruce K. Posey