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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001798749</issuerCik>
            <issuerName>AEROVATE THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-40544</secFileNumber>
            <issuerAddress>
                <ns2:street1>930 Winter Street, Suite M-500</ns2:street1>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02451</ns2:zipCode>
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            <issuerContactPhone>(617) 443-2400</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>RALPH W NIVEN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>4600</noOfUnitsSold>
            <aggregateMarketValue>74995.64</aggregateMarketValue>
            <noOfUnitsOutstanding>27668887</noOfUnitsOutstanding>
            <approxSaleDate>12/05/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/05/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>4600</amountOfSecuritiesAcquired>
            <paymentDate>12/05/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <name>RALPH W NIVEN</name>
                <address>
                    <ns2:street1>930 Winter Street, Suite M-500</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/22/2023</saleDate>
            <amountOfSecuritiesSold>13800</amountOfSecuritiesSold>
            <grossProceeds>207000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>12/05/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/25/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Ralph Niven</signature>
        </noticeSignature>
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144
0001168060
XXXXXXXX
LIVE
0001798749
AEROVATE THERAPEUTICS, INC.
001-40544
930 Winter Street, Suite M-500
Waltham
MA
02451
(617) 443-2400
RALPH W NIVEN
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
4600
74995.64
27668887
12/05/2023
NASDAQ
Common
12/05/2023
Stock Option Exercise
Issuer
N
4600
12/05/2023
Cash
N
RALPH W NIVEN
930 Winter Street, Suite M-500
Waltham
MA
02451
Common
11/22/2023
13800
207000.00
12/05/2023
05/25/2023
/s/ Ralph Niven