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            <secFileNumber>001-37449</secFileNumber>
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            <issuerContactPhone>206-788-4545</issuerContactPhone>
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            <relationshipsToIssuer>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
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            <aggregateMarketValue>1373440.00</aggregateMarketValue>
            <noOfUnitsOutstanding>58097961</noOfUnitsOutstanding>
            <approxSaleDate>01/25/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <acquiredDate>01/25/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>74000</amountOfSecuritiesAcquired>
            <paymentDate>01/25/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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            <sellerDetails>
                <name>10b5-1 Sales for PAUL RICKEY</name>
                <address>
                    <ns2:street1>188 East Blaine Street, Suite 200</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98102</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/19/2023</saleDate>
            <amountOfSecuritiesSold>15213</amountOfSecuritiesSold>
            <grossProceeds>292221.95</grossProceeds>
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                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98102</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/18/2023</saleDate>
            <amountOfSecuritiesSold>1800</amountOfSecuritiesSold>
            <grossProceeds>34203.06</grossProceeds>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/15/2023</saleDate>
            <amountOfSecuritiesSold>45387</amountOfSecuritiesSold>
            <grossProceeds>866383.37</grossProceeds>
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        <securitiesSoldInPast3Months>
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                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98102</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/14/2023</saleDate>
            <amountOfSecuritiesSold>11600</amountOfSecuritiesSold>
            <grossProceeds>220405.76</grossProceeds>
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            <grossProceeds>103649.75</grossProceeds>
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                    <ns2:zipCode>98102</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
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            <amountOfSecuritiesSold>418</amountOfSecuritiesSold>
            <grossProceeds>6693.81</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PAUL RICKEY</name>
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                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98102</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
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            <amountOfSecuritiesSold>63947</amountOfSecuritiesSold>
            <grossProceeds>1026885.18</grossProceeds>
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                    <ns2:zipCode>98102</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/30/2023</saleDate>
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            <grossProceeds>11200.00</grossProceeds>
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        <noticeSignature>
            <noticeDate>01/25/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>06/12/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ James Paul Rickey</signature>
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144
0001606243
XXXXXXXX
LIVE
0001626199
ALPINE IMMUNE SCIENCES INC
001-37449
188 East Blaine Street, Suite 200
Seattle
WA
98102
206-788-4545
JAMES PAUL RICKEY
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
74000
1373440.00
58097961
01/25/2024
NASDAQ
Common
01/25/2024
Exercise of Stock Options
Issuer
N
74000
01/25/2024
Cash
N
10b5-1 Sales for PAUL RICKEY
188 East Blaine Street, Suite 200
Seattle
WA
98102
Common
12/19/2023
15213
292221.95
10b5-1 Sales for PAUL RICKEY
188 East Blaine Street, Suite 200
Seattle
WA
98102
Common
12/18/2023
1800
34203.06
10b5-1 Sales for PAUL RICKEY
188 East Blaine Street, Suite 200
Seattle
WA
98102
Common
12/15/2023
45387
866383.37
10b5-1 Sales for PAUL RICKEY
188 East Blaine Street, Suite 200
Seattle
WA
98102
Common
12/14/2023
11600
220405.76
10b5-1 Sales for PAUL RICKEY
188 East Blaine Street, Suite 200
Seattle
WA
98102
Common
12/06/2023
6446
103649.75
10b5-1 Sales for PAUL RICKEY
188 East Blaine Street, Suite 200
Seattle
WA
98102
Common
12/05/2023
418
6693.81
10b5-1 Sales for PAUL RICKEY
188 East Blaine Street, Suite 200
Seattle
WA
98102
Common
12/04/2023
63947
1026885.18
10b5-1 Sales for PAUL RICKEY
188 East Blaine Street, Suite 200
Seattle
WA
98102
Common
11/30/2023
700
11200.00
10b5-1 Sales for PAUL RICKEY
188 East Blaine Street, Suite 200
Seattle
WA
98102
Common
11/06/2023
18003
288554.10
01/25/2024
06/12/2023
/s/ James Paul Rickey