<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0002005463</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001840706</issuerCik>
            <issuerName>SOPHIA GENETICS SA</issuerName>
            <secFileNumber>001-40627</secFileNumber>
            <issuerAddress>
                <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                <ns2:city>Rolle</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41216941060</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROSS MUKEN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>3378</noOfUnitsSold>
            <aggregateMarketValue>15268.56</aggregateMarketValue>
            <noOfUnitsOutstanding>65230559</noOfUnitsOutstanding>
            <approxSaleDate>07/09/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>07/03/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3378</amountOfSecuritiesAcquired>
            <paymentDate>07/03/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/05/2024</saleDate>
            <amountOfSecuritiesSold>6500</amountOfSecuritiesSold>
            <grossProceeds>30290.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>06/27/2024</saleDate>
            <amountOfSecuritiesSold>445</amountOfSecuritiesSold>
            <grossProceeds>1983.68</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/20/2024</saleDate>
            <amountOfSecuritiesSold>1484</amountOfSecuritiesSold>
            <grossProceeds>7405.16</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>05/28/2024</saleDate>
            <amountOfSecuritiesSold>445</amountOfSecuritiesSold>
            <grossProceeds>2140.45</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/20/2024</saleDate>
            <amountOfSecuritiesSold>1427</amountOfSecuritiesSold>
            <grossProceeds>6478.58</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>04/26/2024</saleDate>
            <amountOfSecuritiesSold>445</amountOfSecuritiesSold>
            <grossProceeds>2140.45</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/19/2024</saleDate>
            <amountOfSecuritiesSold>1426</amountOfSecuritiesSold>
            <grossProceeds>6844.80</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/10/2024</saleDate>
            <amountOfSecuritiesSold>1436</amountOfSecuritiesSold>
            <grossProceeds>7065.12</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were or will be acquired upon the vesting of restricted stock units during the period of 07/03/2024 through 09/22/2024.
</remarks>
        <noticeSignature>
            <noticeDate>07/09/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/15/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Ross Muken</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 8987}]
144
0002005463
XXXXXXXX
LIVE
0001840706
SOPHIA GENETICS SA
001-40627
La Piece 12 ch-1180
Rolle
V8
00000
41216941060
ROSS MUKEN
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
3378
15268.56
65230559
07/09/2024
NASDAQ
Common
07/03/2024
Restricted Stock Units
Issuer
N
3378
07/03/2024
N/A
N
ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
07/05/2024
6500
30290.00
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
COMMON
06/27/2024
445
1983.68
ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
06/20/2024
1484
7405.16
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
COMMON
05/28/2024
445
2140.45
ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
05/20/2024
1427
6478.58
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
COMMON
04/26/2024
445
2140.45
ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/19/2024
1426
6844.80
ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/10/2024
1436
7065.12
The securities to be sold were or will be acquired upon the vesting of restricted stock units during the period of 07/03/2024 through 09/22/2024.
07/09/2024
12/15/2023
/s/ Ross Muken