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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001705745</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001042074</issuerCik>
            <issuerName>CYMABAY THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-36500</secFileNumber>
            <issuerAddress>
                <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                <ns2:city>Newark</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94560</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 293-8800</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>DANIEL MENOLD</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>17500</noOfUnitsSold>
            <aggregateMarketValue>304146.50</aggregateMarketValue>
            <noOfUnitsOutstanding>113403353</noOfUnitsOutstanding>
            <approxSaleDate>11/15/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/15/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>17500</amountOfSecuritiesAcquired>
            <paymentDate>11/15/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>DANIEL MENOLD</name>
                <address>
                    <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                    <ns2:city>Newark</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94560</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/16/2023</saleDate>
            <amountOfSecuritiesSold>17500</amountOfSecuritiesSold>
            <grossProceeds>240868.25</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>DANIEL MENOLD</name>
                <address>
                    <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                    <ns2:city>Newark</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94560</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/15/2023</saleDate>
            <amountOfSecuritiesSold>16545</amountOfSecuritiesSold>
            <grossProceeds>279162.13</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>11/15/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>04/10/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Daniel Patrick Menold</signature>
        </noticeSignature>
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144
0001705745
XXXXXXXX
LIVE
0001042074
CYMABAY THERAPEUTICS, INC.
001-36500
7575 Gateway Blvd, Suite 110
Newark
CA
94560
(510) 293-8800
DANIEL MENOLD
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
17500
304146.50
113403353
11/15/2023
NASDAQ
Common
11/15/2023
Stock Option Exercise
Issuer
N
17500
11/15/2023
Cash
N
DANIEL MENOLD
7575 Gateway Blvd, Suite 110
Newark
CA
94560
Common
10/16/2023
17500
240868.25
DANIEL MENOLD
7575 Gateway Blvd, Suite 110
Newark
CA
94560
Common
09/15/2023
16545
279162.13
11/15/2023
04/10/2023
/s/ Daniel Patrick Menold