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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001717115</issuerCik>
            <issuerName>Tempus AI, Inc. </issuerName>
            <secFileNumber>001-42130</secFileNumber>
            <issuerAddress>
                <ns2:street1>600 WEST CHICAGO AVENUE, Suite 510</ns2:street1>
                <ns2:city>CHICAGO</ns2:city>
                <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                <ns2:zipCode>60654</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8009765448</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JAMES ROGERS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>31780</noOfUnitsSold>
            <aggregateMarketValue>2842403.20</aggregateMarketValue>
            <noOfUnitsOutstanding>152401894</noOfUnitsOutstanding>
            <approxSaleDate>02/18/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>04/17/2019</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>31780</amountOfSecuritiesAcquired>
            <paymentDate>04/17/2019</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JAMES ROGERS</name>
                <address>
                    <ns2:street1>600 WEST CHICAGO AVENUE, Suite 510</ns2:street1>
                    <ns2:city>CHICAGO</ns2:city>
                    <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                    <ns2:zipCode>60654</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/05/2025</saleDate>
            <amountOfSecuritiesSold>8712</amountOfSecuritiesSold>
            <grossProceeds>588669.84</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JAMES ROGERS</name>
                <address>
                    <ns2:street1>600 WEST CHICAGO AVENUE, Suite 510</ns2:street1>
                    <ns2:city>CHICAGO</ns2:city>
                    <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                    <ns2:zipCode>60654</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/16/2024</saleDate>
            <amountOfSecuritiesSold>1468</amountOfSecuritiesSold>
            <grossProceeds>59057.64</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JAMES ROGERS</name>
                <address>
                    <ns2:street1>600 WEST CHICAGO AVENUE, Suite 510</ns2:street1>
                    <ns2:city>CHICAGO</ns2:city>
                    <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                    <ns2:zipCode>60654</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/11/2024</saleDate>
            <amountOfSecuritiesSold>83025</amountOfSecuritiesSold>
            <grossProceeds>3511940.90</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 4/17/2019 through 7/18/2023

</remarks>
        <noticeSignature>
            <noticeDate>02/18/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/06/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jim Rogers</signature>
        </noticeSignature>
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144
0002024630
XXXXXXXX
LIVE
0001717115
Tempus AI, Inc.
001-42130
600 WEST CHICAGO AVENUE, Suite 510
CHICAGO
IL
60654
8009765448
JAMES ROGERS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
31780
2842403.20
152401894
02/18/2025
NASDAQ
Common
04/17/2019
Restricted Stock Units
Issuer
N
31780
04/17/2019
N/A
N
JAMES ROGERS
600 WEST CHICAGO AVENUE, Suite 510
CHICAGO
IL
60654
Common
02/05/2025
8712
588669.84
JAMES ROGERS
600 WEST CHICAGO AVENUE, Suite 510
CHICAGO
IL
60654
Common
12/16/2024
1468
59057.64
10b5-1 Sales for JAMES ROGERS
600 WEST CHICAGO AVENUE, Suite 510
CHICAGO
IL
60654
Common
12/11/2024
83025
3511940.90
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 4/17/2019 through 7/18/2023
02/18/2025
09/06/2024
/s/ Jim Rogers