<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001047058</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001039065</issuerCik>
            <issuerName>OSI SYSTEMS INC</issuerName>
            <secFileNumber>000-23125</secFileNumber>
            <issuerAddress>
                <ns2:street1>12525 Chadron Avenue</ns2:street1>
                <ns2:city>Hawthorne</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>90250</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>3109780516</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>DEEPAK CHOPRA </nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>20000</noOfUnitsSold>
            <aggregateMarketValue>2703600.00</aggregateMarketValue>
            <noOfUnitsOutstanding>16728000</noOfUnitsOutstanding>
            <approxSaleDate>08/30/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/01/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>20000</amountOfSecuritiesAcquired>
            <paymentDate>01/01/2021</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for DEEPAK CHOPRA &amp;NANDINI CHOPRA JT TEN</name>
                <address>
                    <ns2:street1>12525 Chadron Avenue</ns2:street1>
                    <ns2:city>Hawthorne</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>90250</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/01/2023</saleDate>
            <amountOfSecuritiesSold>12620</amountOfSecuritiesSold>
            <grossProceeds>1514830.34</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for DEEPAK CHOPRA &amp;NANDINI CHOPRA JT TEN</name>
                <address>
                    <ns2:street1>12525 Chadron Avenue</ns2:street1>
                    <ns2:city>Hawthorne</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>90250</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/31/2023</saleDate>
            <amountOfSecuritiesSold>27380</amountOfSecuritiesSold>
            <grossProceeds>3256651.13</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 2021 through 2022.
</remarks>
        <noticeSignature>
            <noticeDate>08/30/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/01/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Deepak Chopra</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001047058
XXXXXXXX
LIVE
0001039065
OSI SYSTEMS INC
000-23125
12525 Chadron Avenue
Hawthorne
CA
90250
3109780516
DEEPAK CHOPRA
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
20000
2703600.00
16728000
08/30/2023
NASDAQ
Common
01/01/2021
Restricted Stock Units
Issuer
N
20000
01/01/2021
N/A
N
10b5-1 Sales for DEEPAK CHOPRA &NANDINI CHOPRA JT TEN
12525 Chadron Avenue
Hawthorne
CA
90250
Common
06/01/2023
12620
1514830.34
10b5-1 Sales for DEEPAK CHOPRA &NANDINI CHOPRA JT TEN
12525 Chadron Avenue
Hawthorne
CA
90250
Common
05/31/2023
27380
3256651.13
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 2021 through 2022.
08/30/2023
03/01/2023
/s/ Deepak Chopra