<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001400971</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001178879</issuerCik>
            <issuerName>AMICUS THERAPEUTICS INC</issuerName>
            <secFileNumber>001-33497</secFileNumber>
            <issuerAddress>
                <ns2:street1>3675 Market Street</ns2:street1>
                <ns2:city>Philadelphia</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19104</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>2159217600</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BRADLEY  CAMPBELL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>8300</noOfUnitsSold>
            <aggregateMarketValue>101260.00</aggregateMarketValue>
            <noOfUnitsOutstanding>284576000</noOfUnitsOutstanding>
            <approxSaleDate>06/06/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/20/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>8300</amountOfSecuritiesAcquired>
            <paymentDate>01/20/2020</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for BRADLEY LEWIS CAMPBELL</name>
                <address>
                    <ns2:street1>3675 Market Street</ns2:street1>
                    <ns2:city>Philadelphia</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/01/2023</saleDate>
            <amountOfSecuritiesSold>11700</amountOfSecuritiesSold>
            <grossProceeds>132942.42</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for BRADLEY LEWIS CAMPBELL</name>
                <address>
                    <ns2:street1>3675 Market Street</ns2:street1>
                    <ns2:city>Philadelphia</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/01/2023</saleDate>
            <amountOfSecuritiesSold>11700</amountOfSecuritiesSold>
            <grossProceeds>138092.76</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for BRADLEY LEWIS CAMPBELL</name>
                <address>
                    <ns2:street1>3675 Market Street</ns2:street1>
                    <ns2:city>Philadelphia</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/03/2023</saleDate>
            <amountOfSecuritiesSold>11700</amountOfSecuritiesSold>
            <grossProceeds>131207.31</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/06/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/09/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/S/ Bradley Campbell</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5487}]
144
0001400971
XXXXXXXX
LIVE
0001178879
AMICUS THERAPEUTICS INC
001-33497
3675 Market Street
Philadelphia
PA
19104
2159217600
BRADLEY  CAMPBELL
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
8300
101260.00
284576000
06/06/2023
NASDAQ
Common
01/20/2020
Performance Stock Units
Issuer
N
8300
01/20/2020
N/A
N
10b5-1 Sales Plan for BRADLEY LEWIS CAMPBELL
3675 Market Street
Philadelphia
PA
19104
Common
06/01/2023
11700
132942.42
10b5-1 Sales Plan for BRADLEY LEWIS CAMPBELL
3675 Market Street
Philadelphia
PA
19104
Common
05/01/2023
11700
138092.76
10b5-1 Sales Plan for BRADLEY LEWIS CAMPBELL
3675 Market Street
Philadelphia
PA
19104
Common
04/03/2023
11700
131207.31
06/06/2023
12/09/2022
/S/ Bradley Campbell