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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001611681</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001402436</issuerCik>
            <issuerName>SS&amp;C TECHNOLOGIES HOLDINGS, INC.</issuerName>
            <secFileNumber>001-34675</secFileNumber>
            <issuerAddress>
                <ns2:street1>80 Lamberton Road</ns2:street1>
                <ns2:city>Windsor</ns2:city>
                <ns2:stateOrCountry>CT</ns2:stateOrCountry>
                <ns2:zipCode>06095</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>860-298-4500</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MICHAEL ZAMKOW</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>10000</noOfUnitsSold>
            <aggregateMarketValue>616925.00</aggregateMarketValue>
            <noOfUnitsOutstanding>247323277</noOfUnitsOutstanding>
            <approxSaleDate>06/04/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/09/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
            <paymentDate>05/09/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL ZAMKOW</name>
                <address>
                    <ns2:street1>80 Lamberton Road</ns2:street1>
                    <ns2:city>Windsor</ns2:city>
                    <ns2:stateOrCountry>CT</ns2:stateOrCountry>
                    <ns2:zipCode>06095</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/23/2024</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>619206.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL ZAMKOW</name>
                <address>
                    <ns2:street1>80 Lamberton Road</ns2:street1>
                    <ns2:city>Windsor</ns2:city>
                    <ns2:stateOrCountry>CT</ns2:stateOrCountry>
                    <ns2:zipCode>06095</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/16/2024</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>639400.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL ZAMKOW</name>
                <address>
                    <ns2:street1>80 Lamberton Road</ns2:street1>
                    <ns2:city>Windsor</ns2:city>
                    <ns2:stateOrCountry>CT</ns2:stateOrCountry>
                    <ns2:zipCode>06095</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/09/2024</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>315720.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/04/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Michael Jay Zamkow</signature>
        </noticeSignature>
    </formData>
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144
0001611681
XXXXXXXX
LIVE
0001402436
SS&C TECHNOLOGIES HOLDINGS, INC.
001-34675
80 Lamberton Road
Windsor
CT
06095
860-298-4500
MICHAEL ZAMKOW
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
10000
616925.00
247323277
06/04/2024
NASDAQ
Common
05/09/2024
Exercise of options under a registered plan
Issuer
N
10000
05/09/2024
Cash
N
MICHAEL ZAMKOW
80 Lamberton Road
Windsor
CT
06095
Common
05/23/2024
10000
619206.00
MICHAEL ZAMKOW
80 Lamberton Road
Windsor
CT
06095
Common
05/16/2024
10000
639400.00
MICHAEL ZAMKOW
80 Lamberton Road
Windsor
CT
06095
Common
05/09/2024
5000
315720.50
06/04/2024
/s/ Michael Jay Zamkow