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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>001-38938</secFileNumber>
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                <ns2:city>Bedford</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>01730</ns2:zipCode>
            </issuerAddress>
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            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
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        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>9007</noOfUnitsSold>
            <aggregateMarketValue>102229.45</aggregateMarketValue>
            <noOfUnitsOutstanding>54596924</noOfUnitsOutstanding>
            <approxSaleDate>07/01/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/15/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>9007</amountOfSecuritiesAcquired>
            <paymentDate>03/15/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <name>10b5-1 Sales for BARUCH TICHO</name>
                <address>
                    <ns2:street1>45 Wiggins Ave</ns2:street1>
                    <ns2:city>Bedford</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>01730</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/03/2025</saleDate>
            <amountOfSecuritiesSold>6471</amountOfSecuritiesSold>
            <grossProceeds>64892.48</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for BARUCH TICHO</name>
                <address>
                    <ns2:street1>45 Wiggins Ave</ns2:street1>
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                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>01730</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/02/2025</saleDate>
            <amountOfSecuritiesSold>1745</amountOfSecuritiesSold>
            <grossProceeds>17450.00</grossProceeds>
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                    <ns2:zipCode>01730</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/02/2025</saleDate>
            <amountOfSecuritiesSold>22790</amountOfSecuritiesSold>
            <grossProceeds>228542.93</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
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                <name>10b5-1 Sales for BARUCH TICHO</name>
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                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>01730</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/01/2025</saleDate>
            <amountOfSecuritiesSold>3841</amountOfSecuritiesSold>
            <grossProceeds>38410.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>07/01/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/11/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ BARUCH TICHO</signature>
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144
0001780088
XXXXXXXX
LIVE
0001623526
STOKE THERAPEUTICS INC
001-38938
45 Wiggins Ave
Bedford
MA
01730
7814308200
BARUCH TICHO
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
9007
102229.45
54596924
07/01/2025
NASDAQ
Common
03/15/2025
Restricted Stock Units
Issuer
N
9007
03/15/2025
N/A
N
10b5-1 Sales for BARUCH TICHO
45 Wiggins Ave
Bedford
MA
01730
Common
06/03/2025
6471
64892.48
10b5-1 Sales for BARUCH TICHO
45 Wiggins Ave
Bedford
MA
01730
Common
06/02/2025
1745
17450.00
10b5-1 Sales for BARUCH TICHO
45 Wiggins Ave
Bedford
MA
01730
Common
05/02/2025
22790
228542.93
10b5-1 Sales for BARUCH TICHO
45 Wiggins Ave
Bedford
MA
01730
Common
05/01/2025
3841
38410.00
07/01/2025
12/11/2024
/s/ BARUCH TICHO