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      <securitiesClassTitle>Common</securitiesClassTitle>
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      <securitiesClassTitle>Common</securitiesClassTitle>
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    <noticeSignature>
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      <planAdoptionDates>
        <planAdoptionDate>02/28/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Carli McPherson, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Sarah Condella</signature>
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144
0001839989
XXXXXXXX
LIVE
0001124140
EXACT SCIENCES CORP
001-35092
5505 ENDEAVOR LANE
MADISON
WI
53719
608-284-5700
Condella Sarah
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
1000
67190.00
178217142
04/03/2023
NASDAQ
Common
01/16/2019
Restricted Stock Vesting
Issuer
N
1000
01/16/2019
Compensation
N
Sarah Condella
5505 Endeavor Lane
Madison
WI
53719
Common
01/09/2023
1000
60000.00
Sarah Condella
5505 Endeavor Lane
Madison
WI
53719
Common
02/01/2023
1000
67930.00
Sarah Condella
5505 Endeavor Lane
Madison
WI
53719
Common
02/15/2023
954
62575.44
Sarah Condella
5505 Endeavor Lane
Madison
WI
53719
Common
02/16/2023
1076
68767.16
Sarah Condella
5505 Endeavor Lane
Madison
WI
53719
Common
02/22/2023
1033
64784.29
Sarah Condella
5505 Endeavor Lane
Madison
WI
53719
Common
02/28/2023
2924
178717.22
Sarah Condella
5505 Endeavor Lane
Madison
WI
53719
Common
03/01/2023
1000
62000.00
04/03/2023
02/28/2022
/s/ Carli McPherson, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Sarah Condella