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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001644557</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001192448</issuerCik>
      <issuerName>GLAUKOS Corp</issuerName>
      <secFileNumber>001-37463</secFileNumber>
      <issuerAddress>
        <com:street1>229 AVENIDA FABRICANTE</com:street1>
        <com:city>SAN CLEMENTE</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92672</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>949-367-9600</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Burns Thomas William</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1</noOfUnitsSold>
      <aggregateMarketValue>60.21</aggregateMarketValue>
      <noOfUnitsOutstanding>48208692</noOfUnitsOutstanding>
      <approxSaleDate>05/19/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/19/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted - 07/10/2014</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1</amountOfSecuritiesAcquired>
      <paymentDate>05/19/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Thomas Burns</name>
        <address>
          <com:street1>One Glaukos Way</com:street1>
          <com:city>Aliso Viejo</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92656</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/15/2023</saleDate>
      <amountOfSecuritiesSold>3864</amountOfSecuritiesSold>
      <grossProceeds>231942.01</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Thomas Burns</name>
        <address>
          <com:street1>One Glaukos Way</com:street1>
          <com:city>Aliso Viejo</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92656</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/16/2023</saleDate>
      <amountOfSecuritiesSold>3704</amountOfSecuritiesSold>
      <grossProceeds>222271.48</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Thomas Burns</name>
        <address>
          <com:street1>One Glaukos Way</com:street1>
          <com:city>Aliso Viejo</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92656</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/17/2023</saleDate>
      <amountOfSecuritiesSold>620</amountOfSecuritiesSold>
      <grossProceeds>37223.37</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Thomas Burns</name>
        <address>
          <com:street1>One Glaukos Way</com:street1>
          <com:city>Aliso Viejo</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92656</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/18/2023</saleDate>
      <amountOfSecuritiesSold>11662</amountOfSecuritiesSold>
      <grossProceeds>701746.86</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/19/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>02/24/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Gary Redman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Thomas Burns</signature>
    </noticeSignature>
  </formData>
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144
0001644557
XXXXXXXX
LIVE
0001192448
GLAUKOS Corp
001-37463
229 AVENIDA FABRICANTE
SAN CLEMENTE
CA
92672
949-367-9600
Burns Thomas William
Officer
Director
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
1
60.21
48208692
05/19/2023
NYSE
Common
05/19/2023
Option Granted - 07/10/2014
Issuer
N
1
05/19/2023
Cash
N
Thomas Burns
One Glaukos Way
Aliso Viejo
CA
92656
Common
05/15/2023
3864
231942.01
Thomas Burns
One Glaukos Way
Aliso Viejo
CA
92656
Common
05/16/2023
3704
222271.48
Thomas Burns
One Glaukos Way
Aliso Viejo
CA
92656
Common
05/17/2023
620
37223.37
Thomas Burns
One Glaukos Way
Aliso Viejo
CA
92656
Common
05/18/2023
11662
701746.86
05/19/2023
02/24/2023
/s/ Gary Redman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Thomas Burns