<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001365306</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000318154</issuerCik>
      <issuerName>AMGEN INC</issuerName>
      <secFileNumber>001-37702</secFileNumber>
      <issuerAddress>
        <com:street1>ONE AMGEN CENTER DRIVE</com:street1>
        <com:city>THOUSAND OAKS</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>91320</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(805)447-1000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Graham Jonathan P</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab Corporation</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>10000</noOfUnitsSold>
      <aggregateMarketValue>2728300.00</aggregateMarketValue>
      <noOfUnitsOutstanding>535178027</noOfUnitsOutstanding>
      <approxSaleDate>11/08/2023</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>08/14/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Unit</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
      <paymentDate>08/14/2018</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Table I acquisition and payment date range: 08/14/2018 through 11/02/2023

2a) The Graham-Ulmer Family Trust 6/24/2019, Jonathan Graham &amp; Elizabeth Ulmer TTEES</remarks>
    <noticeSignature>
      <noticeDate>11/08/2023</noticeDate>
      <signature>Jonathan P Graham TTEE for The Graham-Ulmer Fam Trust</signature>
    </noticeSignature>
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144
0001365306
XXXXXXXX
LIVE
0000318154
AMGEN INC
001-37702
ONE AMGEN CENTER DRIVE
THOUSAND OAKS
CA
91320
(805)447-1000
Graham Jonathan P
Officer
Common
Charles Schwab Corporation
3000 Schwab Way
Westlake
TX
76262
10000
2728300.00
535178027
11/08/2023
Nasdaq
Common
08/14/2018
Restricted Stock Unit
Issuer
N
10000
08/14/2018
Equity Compensation
Y
Table I acquisition and payment date range: 08/14/2018 through 11/02/2023

2a) The Graham-Ulmer Family Trust 6/24/2019, Jonathan Graham & Elizabeth Ulmer TTEES
11/08/2023
Jonathan P Graham TTEE for The Graham-Ulmer Fam Trust