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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001042074</issuerCik>
            <issuerName>CYMABAY THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-36500</secFileNumber>
            <issuerAddress>
                <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                <ns2:city>Newark</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94560</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 293-8800</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JANET DORLING</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>6000</noOfUnitsSold>
            <aggregateMarketValue>143143.80</aggregateMarketValue>
            <noOfUnitsOutstanding>113403353</noOfUnitsOutstanding>
            <approxSaleDate>01/10/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>01/10/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6000</amountOfSecuritiesAcquired>
            <paymentDate>01/10/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <name>JANET DORLING</name>
                <address>
                    <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                    <ns2:city>Newark</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94560</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/11/2023</saleDate>
            <amountOfSecuritiesSold>6000</amountOfSecuritiesSold>
            <grossProceeds>120421.80</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JANET DORLING</name>
                <address>
                    <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                    <ns2:city>Newark</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94560</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/10/2023</saleDate>
            <amountOfSecuritiesSold>7000</amountOfSecuritiesSold>
            <grossProceeds>106699.60</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>01/10/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/09/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Janet Dorling</signature>
        </noticeSignature>
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144
0001738144
XXXXXXXX
LIVE
0001042074
CYMABAY THERAPEUTICS, INC.
001-36500
7575 Gateway Blvd, Suite 110
Newark
CA
94560
(510) 293-8800
JANET DORLING
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
6000
143143.80
113403353
01/10/2024
NASDAQ
COMMON
01/10/2024
Stock Option Exercise
ISSUER
N
6000
01/10/2024
Cash
N
JANET DORLING
7575 Gateway Blvd, Suite 110
Newark
CA
94560
Common
12/11/2023
6000
120421.80
JANET DORLING
7575 Gateway Blvd, Suite 110
Newark
CA
94560
Common
11/10/2023
7000
106699.60
01/10/2024
08/09/2023
/s/ Janet Dorling