<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001888075</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001534969</issuerCik>
            <issuerName>SERA PROGNOSTICS INC</issuerName>
            <secFileNumber>001-40606</secFileNumber>
            <issuerAddress>
                <ns2:street1>2749 East Parleys Way, Suite 200</ns2:street1>
                <ns2:city>Salt Lake City</ns2:city>
                <ns2:stateOrCountry>UT</ns2:stateOrCountry>
                <ns2:zipCode>84109</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8019900520</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PAUL KEARNEY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>52231</noOfUnitsSold>
            <aggregateMarketValue>434561.92</aggregateMarketValue>
            <noOfUnitsOutstanding>32804741</noOfUnitsOutstanding>
            <approxSaleDate>01/10/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/10/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>15000</amountOfSecuritiesAcquired>
            <paymentDate>01/10/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/06/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>37231</amountOfSecuritiesAcquired>
            <paymentDate>03/06/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>PAUL KEARNEY</name>
                <address>
                    <ns2:street1>2749 East Parleys Way, Suite 200</ns2:street1>
                    <ns2:city>Salt Lake City</ns2:city>
                    <ns2:stateOrCountry>UT</ns2:stateOrCountry>
                    <ns2:zipCode>84109</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/11/2024</saleDate>
            <amountOfSecuritiesSold>4078</amountOfSecuritiesSold>
            <grossProceeds>29850.96</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. The securities to be sold were acquired upon the vesting of restricted stock units during the period of 3/6/2024 through 11/6/2024.
</remarks>
        <noticeSignature>
            <noticeDate>01/10/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/14/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Paul Kearney</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4967}]
144
0001888075
XXXXXXXX
LIVE
0001534969
SERA PROGNOSTICS INC
001-40606
2749 East Parleys Way, Suite 200
Salt Lake City
UT
84109
8019900520
PAUL KEARNEY
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
52231
434561.92
32804741
01/10/2025
NASDAQ
Common
01/10/2025
Exercise of Stock Options
Issuer
N
15000
01/10/2025
Cash
Common
03/06/2024
Restricted Stock Units
Issuer
N
37231
03/06/2024
N/A
N
PAUL KEARNEY
2749 East Parleys Way, Suite 200
Salt Lake City
UT
84109
Common
11/11/2024
4078
29850.96
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. The securities to be sold were acquired upon the vesting of restricted stock units during the period of 3/6/2024 through 11/6/2024.
01/10/2025
05/14/2024
/s/ Paul Kearney