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            <issuerName>HARMONY BIOSCIENCES HOLDINGS, INC.</issuerName>
            <secFileNumber>001-39450</secFileNumber>
            <issuerAddress>
                <ns2:street1>630 W. Germantown Pike, Suite 215</ns2:street1>
                <ns2:city>Plymouth Meeting</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19462</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(484) 539-9800</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JEFFREY G DIERKS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Former Officer</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>9844</noOfUnitsSold>
            <aggregateMarketValue>350083.16</aggregateMarketValue>
            <noOfUnitsOutstanding>57424319</noOfUnitsOutstanding>
            <approxSaleDate>05/19/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/07/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>9844</amountOfSecuritiesAcquired>
            <paymentDate>05/07/2025</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <name>JEFFREY G DIERKS</name>
                <address>
                    <ns2:street1>630 W. Germantown Pike, Suite 215</ns2:street1>
                    <ns2:city>Plymouth Meeting</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19462</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/16/2025</saleDate>
            <amountOfSecuritiesSold>2292</amountOfSecuritiesSold>
            <grossProceeds>80426.74</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
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                    <ns2:city>Plymouth Meeting</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19462</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/12/2025</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>175955.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
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                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19462</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/09/2025</saleDate>
            <amountOfSecuritiesSold>4972</amountOfSecuritiesSold>
            <grossProceeds>170119.47</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JEFFREY G DIERKS</name>
                <address>
                    <ns2:street1>630 W. Germantown Pike, Suite 215</ns2:street1>
                    <ns2:city>Plymouth Meeting</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19462</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/08/2025</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>170149.00</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JEFFREY G DIERKS</name>
                <address>
                    <ns2:street1>630 W. Germantown Pike, Suite 215</ns2:street1>
                    <ns2:city>Plymouth Meeting</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19462</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/08/2025</saleDate>
            <amountOfSecuritiesSold>8000</amountOfSecuritiesSold>
            <grossProceeds>268724.00</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JEFFREY G DIERKS</name>
                <address>
                    <ns2:street1>630 W. Germantown Pike, Suite 215</ns2:street1>
                    <ns2:city>Plymouth Meeting</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19462</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/07/2025</saleDate>
            <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
            <grossProceeds>483807.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JEFFREY G DIERKS</name>
                <address>
                    <ns2:street1>630 W. Germantown Pike, Suite 215</ns2:street1>
                    <ns2:city>Plymouth Meeting</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19462</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/07/2025</saleDate>
            <amountOfSecuritiesSold>16000</amountOfSecuritiesSold>
            <grossProceeds>522838.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Jeffrey Dierks</name>
                <address>
                    <ns2:street1>630 W. Germantown Pike, Suite 215</ns2:street1>
                    <ns2:city>Plymouth Meeting</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19462</ns2:zipCode>
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            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/03/2025</saleDate>
            <amountOfSecuritiesSold>4869</amountOfSecuritiesSold>
            <grossProceeds>158834.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/19/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Jeffrey Gustave Dierks</signature>
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144
0001821102
XXXXXXXX
LIVE
0001802665
HARMONY BIOSCIENCES HOLDINGS, INC.
001-39450
630 W. Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
(484) 539-9800
JEFFREY G DIERKS
Former Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
9844
350083.16
57424319
05/19/2025
NASDAQ
Common
05/07/2025
Exercise of options under a registered plan
Issuer
N
9844
05/07/2025
Services Rendered
N
JEFFREY G DIERKS
630 W. Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
05/16/2025
2292
80426.74
JEFFREY G DIERKS
630 W. Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
05/12/2025
5000
175955.00
JEFFREY G DIERKS
630 W. Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
05/09/2025
4972
170119.47
JEFFREY G DIERKS
630 W. Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
05/08/2025
5000
170149.00
JEFFREY G DIERKS
630 W. Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
05/08/2025
8000
268724.00
JEFFREY G DIERKS
630 W. Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
05/07/2025
15000
483807.00
JEFFREY G DIERKS
630 W. Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
05/07/2025
16000
522838.40
Jeffrey Dierks
630 W. Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
03/03/2025
4869
158834.00
05/19/2025
/s/ Jeffrey Gustave Dierks