<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001014095</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001157601</issuerCik>
            <issuerName>MADRIGAL PHARMACEUTICALS, INC.</issuerName>
            <secFileNumber>001-33277</secFileNumber>
            <issuerAddress>
                <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                <ns2:street2>Suite 200</ns2:street2>
                <ns2:city>West Conshohocken</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19428</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(267) 824-2827</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>FRED CRAVES</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>7742</noOfUnitsSold>
            <aggregateMarketValue>2518053.76</aggregateMarketValue>
            <noOfUnitsOutstanding>22080246</noOfUnitsOutstanding>
            <approxSaleDate>03/13/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/06/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7742</amountOfSecuritiesAcquired>
            <paymentDate>03/06/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name> FRED CRAVES</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/12/2025</saleDate>
            <amountOfSecuritiesSold>1428</amountOfSecuritiesSold>
            <grossProceeds>473878.08</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name> FRED CRAVES</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/12/2025</saleDate>
            <amountOfSecuritiesSold>6000</amountOfSecuritiesSold>
            <grossProceeds>1991084.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name> FRED CRAVES</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/12/2025</saleDate>
            <amountOfSecuritiesSold>300</amountOfSecuritiesSold>
            <grossProceeds>99554.22</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>03/13/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Fred Craves</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5570}]
144
0001014095
XXXXXXXX
LIVE
0001157601
MADRIGAL PHARMACEUTICALS, INC.
001-33277
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
(267) 824-2827
FRED CRAVES
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
7742
2518053.76
22080246
03/13/2025
NASDAQ
Common
03/06/2025
Exercise of options under a registered plan
Issuer
N
7742
03/06/2025
Cash
N
FRED CRAVES
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
03/12/2025
1428
473878.08
FRED CRAVES
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
03/12/2025
6000
1991084.40
FRED CRAVES
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
03/12/2025
300
99554.22
03/13/2025
/s/ Fred Craves