<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001711968</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001604821</issuerCik>
            <issuerName>NATERA, INC.</issuerName>
            <secFileNumber>001-37478</secFileNumber>
            <issuerAddress>
                <ns2:street1>13011 McCallen Pass</ns2:street1>
                <ns2:street2>Building A Suite 100</ns2:street2>
                <ns2:city>Austin</ns2:city>
                <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                <ns2:zipCode>78753</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 980-9190</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEVEN L CHAPMAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>5343</noOfUnitsSold>
            <aggregateMarketValue>889777.80</aggregateMarketValue>
            <noOfUnitsOutstanding>136546580</noOfUnitsOutstanding>
            <approxSaleDate>07/01/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/21/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5343</amountOfSecuritiesAcquired>
            <paymentDate>01/21/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/02/2025</saleDate>
            <amountOfSecuritiesSold>6111</amountOfSecuritiesSold>
            <grossProceeds>960062.54</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/01/2025</saleDate>
            <amountOfSecuritiesSold>6980</amountOfSecuritiesSold>
            <grossProceeds>1047702.19</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/28/2025</saleDate>
            <amountOfSecuritiesSold>6203</amountOfSecuritiesSold>
            <grossProceeds>943987.43</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/21/2025</saleDate>
            <amountOfSecuritiesSold>1664</amountOfSecuritiesSold>
            <grossProceeds>242189.72</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock during the period of 1/21/2022 through 4/27/2025.</remarks>
        <noticeSignature>
            <noticeDate>07/01/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/02/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Steven Leonard Chapman</signature>
        </noticeSignature>
    </formData>
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144
0001711968
XXXXXXXX
LIVE
0001604821
NATERA, INC.
001-37478
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
(650) 980-9190
STEVEN L CHAPMAN
Officer
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
5343
889777.80
136546580
07/01/2025
NASDAQ
Common
01/21/2022
Restricted Stock
Issuer
N
5343
01/21/2022
Not Applicable
N
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
06/02/2025
6111
960062.54
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
05/01/2025
6980
1047702.19
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
04/28/2025
6203
943987.43
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
04/21/2025
1664
242189.72
The securities to be sold were acquired upon the vesting of restricted stock during the period of 1/21/2022 through 4/27/2025.
07/01/2025
12/02/2024
/s/ Steven Leonard Chapman