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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001744659</issuerCik>
            <issuerName>AKERO THERAPEUTICS INC</issuerName>
            <secFileNumber>001-38944</secFileNumber>
            <issuerAddress>
                <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                <ns2:city>South San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6504876488</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CATRIONA YALE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>69073</noOfUnitsSold>
            <aggregateMarketValue>1808331.14</aggregateMarketValue>
            <noOfUnitsOutstanding>69799148</noOfUnitsOutstanding>
            <approxSaleDate>01/27/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/27/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>69073</amountOfSecuritiesAcquired>
            <paymentDate>01/27/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CATRIONA YALE</name>
                <address>
                    <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/16/2024</saleDate>
            <amountOfSecuritiesSold>9074</amountOfSecuritiesSold>
            <grossProceeds>264117.83</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CATRIONA YALE</name>
                <address>
                    <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/10/2024</saleDate>
            <amountOfSecuritiesSold>2810</amountOfSecuritiesSold>
            <grossProceeds>86519.90</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CATRIONA YALE</name>
                <address>
                    <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/15/2024</saleDate>
            <amountOfSecuritiesSold>9061</amountOfSecuritiesSold>
            <grossProceeds>251274.22</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CATRIONA YALE</name>
                <address>
                    <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/06/2024</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>351892.00</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CATRIONA YALE</name>
                <address>
                    <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/01/2024</saleDate>
            <amountOfSecuritiesSold>15485</amountOfSecuritiesSold>
            <grossProceeds>505106.76</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CATRIONA YALE</name>
                <address>
                    <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/30/2024</saleDate>
            <amountOfSecuritiesSold>4515</amountOfSecuritiesSold>
            <grossProceeds>146855.79</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>01/27/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/24/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Catriona Yale</signature>
        </noticeSignature>
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144
0001779308
XXXXXXXX
LIVE
0001744659
AKERO THERAPEUTICS INC
001-38944
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
6504876488
CATRIONA YALE
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
69073
1808331.14
69799148
01/27/2025
NASDAQ
Common
01/27/2025
Exercise of Stock Options
Issuer
N
69073
01/27/2025
Cash
N
10b5-1 Sales for CATRIONA YALE
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
Common
12/16/2024
9074
264117.83
CATRIONA YALE
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
Common
12/10/2024
2810
86519.90
10b5-1 Sales for CATRIONA YALE
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
Common
11/15/2024
9061
251274.22
10b5-1 Sales for CATRIONA YALE
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
Common
11/06/2024
10000
351892.00
10b5-1 Sales for CATRIONA YALE
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
Common
11/01/2024
15485
505106.76
10b5-1 Sales for CATRIONA YALE
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
Common
10/30/2024
4515
146855.79
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
01/27/2025
05/24/2024
/s/ Catriona Yale