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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001955589</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001776985</issuerCik>
      <issuerName>BioNTech SE</issuerName>
      <secFileNumber>001-39081</secFileNumber>
      <issuerAddress>
        <com:street1>AN DER GOLDGRUBE 12</com:street1>
        <com:city>MAINZ</com:city>
        <com:stateOrCountry>2M</com:stateOrCountry>
        <com:zipCode>55131</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>0049613190840</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Poetting Sierk</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Berenberg Capital Markets LLC</name>
        <address>
          <com:street1>1251 Avenue of the Americas</com:street1>
          <com:street2>53rd Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10020</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>120000</noOfUnitsSold>
      <aggregateMarketValue>14349600.00</aggregateMarketValue>
      <noOfUnitsOutstanding>239739752</noOfUnitsOutstanding>
      <approxSaleDate>02/20/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq Global Select</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Ordinary Shares, no par value per share</securitiesClassTitle>
      <acquiredDate>11/18/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>BioNTech SE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>120000</amountOfSecuritiesAcquired>
      <paymentDate>11/18/2022</paymentDate>
      <natureOfPayment>Stock Option Exercise</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>The filing of this Form 144 shall not be construed as an admission that the undersigned is an affiliate of the issuer.</remarks>
    <noticeSignature>
      <noticeDate>02/20/2025</noticeDate>
      <signature>/s/ Sierk Poetting</signature>
    </noticeSignature>
  </formData>
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144
0001955589
XXXXXXXX
LIVE
0001776985
BioNTech SE
001-39081
AN DER GOLDGRUBE 12
MAINZ
2M
55131
0049613190840
Poetting Sierk
Officer
American Depositary Shares representing ordinary shares, no par value per share
Berenberg Capital Markets LLC
1251 Avenue of the Americas
53rd Floor
New York
NY
10020
120000
14349600.00
239739752
02/20/2025
Nasdaq Global Select
Ordinary Shares, no par value per share
11/18/2022
Stock Option Exercise
BioNTech SE
N
120000
11/18/2022
Stock Option Exercise
Y
The filing of this Form 144 shall not be construed as an admission that the undersigned is an affiliate of the issuer.
02/20/2025
/s/ Sierk Poetting