<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001780088</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001623526</issuerCik>
            <issuerName>STOKE THERAPEUTICS INC</issuerName>
            <secFileNumber>001-38938</secFileNumber>
            <issuerAddress>
                <ns2:street1>45 Wiggins Ave</ns2:street1>
                <ns2:city>Bedford</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>01730</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>7814308200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BARUCH TICHO</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>30000</noOfUnitsSold>
            <aggregateMarketValue>449100.00</aggregateMarketValue>
            <noOfUnitsOutstanding>52119860</noOfUnitsOutstanding>
            <approxSaleDate>08/01/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/01/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>30000</amountOfSecuritiesAcquired>
            <paymentDate>08/01/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for BARUCH S. TICHO</name>
                <address>
                    <ns2:street1>45 Wiggins Ave</ns2:street1>
                    <ns2:city>Bedford</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>01730</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/01/2024</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>137458.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for BARUCH S. TICHO</name>
                <address>
                    <ns2:street1>45 Wiggins Ave</ns2:street1>
                    <ns2:city>Bedford</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>01730</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/03/2024</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>152184.88</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>08/01/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/14/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ BARUCH TICHO</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001780088
XXXXXXXX
LIVE
0001623526
STOKE THERAPEUTICS INC
001-38938
45 Wiggins Ave
Bedford
MA
01730
7814308200
BARUCH TICHO
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
30000
449100.00
52119860
08/01/2024
NASDAQ
Common
08/01/2024
Exercise of Stock Options
Issuer
N
30000
08/01/2024
Cash
N
10b5-1 Sales Plan for BARUCH S. TICHO
45 Wiggins Ave
Bedford
MA
01730
Common
07/01/2024
10000
137458.00
10b5-1 Sales Plan for BARUCH S. TICHO
45 Wiggins Ave
Bedford
MA
01730
Common
06/03/2024
10000
152184.88
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
08/01/2024
09/14/2023
/s/ BARUCH TICHO