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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerName>SOPHIA GENETICS SA</issuerName>
            <secFileNumber>001-40627</secFileNumber>
            <issuerAddress>
                <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                <ns2:city>Rolle</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41216941060</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROSS J MUKEN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>14509</noOfUnitsSold>
            <aggregateMarketValue>44107.36</aggregateMarketValue>
            <noOfUnitsOutstanding>66687085</noOfUnitsOutstanding>
            <approxSaleDate>06/20/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/18/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>14509</amountOfSecuritiesAcquired>
            <paymentDate>06/18/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/23/2025</saleDate>
            <amountOfSecuritiesSold>131</amountOfSecuritiesSold>
            <grossProceeds>377.25</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
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                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/19/2025</saleDate>
            <amountOfSecuritiesSold>761</amountOfSecuritiesSold>
            <grossProceeds>2186.66</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/23/2025</saleDate>
            <amountOfSecuritiesSold>131</amountOfSecuritiesSold>
            <grossProceeds>397.69</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/21/2025</saleDate>
            <amountOfSecuritiesSold>761</amountOfSecuritiesSold>
            <grossProceeds>2072.13</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/09/2025</saleDate>
            <amountOfSecuritiesSold>6785</amountOfSecuritiesSold>
            <grossProceeds>19097.06</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/08/2025</saleDate>
            <amountOfSecuritiesSold>1877</amountOfSecuritiesSold>
            <grossProceeds>5185.02</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/07/2025</saleDate>
            <amountOfSecuritiesSold>1865</amountOfSecuritiesSold>
            <grossProceeds>4999.88</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/04/2025</saleDate>
            <amountOfSecuritiesSold>1533</amountOfSecuritiesSold>
            <grossProceeds>4211.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/03/2025</saleDate>
            <amountOfSecuritiesSold>567</amountOfSecuritiesSold>
            <grossProceeds>1726.97</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ROSS J MUKEN</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/24/2025</saleDate>
            <amountOfSecuritiesSold>131</amountOfSecuritiesSold>
            <grossProceeds>407.41</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 06/18/2025 through 09/18/2025.
</remarks>
        <noticeSignature>
            <noticeDate>06/20/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/10/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Ross J Muken</signature>
        </noticeSignature>
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144
0002005463
XXXXXXXX
LIVE
0001840706
SOPHIA GENETICS SA
001-40627
La Piece 12 ch-1180
Rolle
V8
00000
41216941060
ROSS J MUKEN
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
14509
44107.36
66687085
06/20/2025
NASDAQ
Common
06/18/2025
Restricted Stock Units
Issuer
N
14509
06/18/2025
N/A
N
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
05/23/2025
131
377.25
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
05/19/2025
761
2186.66
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/23/2025
131
397.69
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/21/2025
761
2072.13
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/09/2025
6785
19097.06
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/08/2025
1877
5185.02
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/07/2025
1865
4999.88
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/04/2025
1533
4211.00
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/03/2025
567
1726.97
10b5-1 Sales for ROSS J MUKEN
La Piece 12 ch-1180
Rolle
V8
00000
Common
03/24/2025
131
407.41
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 06/18/2025 through 09/18/2025.
06/20/2025
09/10/2024
/s/ Ross J Muken