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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>001-41740</secFileNumber>
            <issuerAddress>
                <ns2:street1>221 Crescent St., Building 17</ns2:street1>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02453</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6503945230</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CARL DAMBKOWSKI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
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            <aggregateMarketValue>331529.10</aggregateMarketValue>
            <noOfUnitsOutstanding>59503184</noOfUnitsOutstanding>
            <approxSaleDate>04/02/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/16/2022</acquiredDate>
            <natureOfAcquisitionTransaction>RSA</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>9310</amountOfSecuritiesAcquired>
            <paymentDate>09/16/2022</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <address>
                    <ns2:street1>221 Crescent St., Building 17</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02453</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/05/2025</saleDate>
            <amountOfSecuritiesSold>1590</amountOfSecuritiesSold>
            <grossProceeds>48463.20</grossProceeds>
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                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02453</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/05/2025</saleDate>
            <amountOfSecuritiesSold>795</amountOfSecuritiesSold>
            <grossProceeds>32141.85</grossProceeds>
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                    <ns2:zipCode>02453</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/05/2025</saleDate>
            <amountOfSecuritiesSold>2725</amountOfSecuritiesSold>
            <grossProceeds>111095.86</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/02/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/21/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Carl Dambkowski</signature>
        </noticeSignature>
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144
0001983476
XXXXXXXX
LIVE
0001974640
APOGEE THERAPEUTICS INC
001-41740
221 Crescent St., Building 17
Waltham
MA
02453
6503945230
CARL DAMBKOWSKI
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
9310
331529.10
59503184
04/02/2025
NASDAQ
Common
09/16/2022
RSA
Issuer
N
9310
09/16/2022
N/A
N
10b5-1 Sales for CARL L DAMBKOWSKI
221 Crescent St., Building 17
Waltham
MA
02453
Common
03/05/2025
1590
48463.20
10b5-1 Sales for CARL L DAMBKOWSKI
221 Crescent St., Building 17
Waltham
MA
02453
Common
02/05/2025
795
32141.85
10b5-1 Sales for CARL L DAMBKOWSKI
221 Crescent St., Building 17
Waltham
MA
02453
Common
02/05/2025
2725
111095.86
04/02/2025
08/21/2024
/s/ Carl Dambkowski