<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001783908</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001232524</issuerCik>
            <issuerName>JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY</issuerName>
            <secFileNumber>001-33500</secFileNumber>
            <issuerAddress>
                <ns2:street1>Fifth Floor, Waterloo Exchange</ns2:street1>
                <ns2:street2>Waterloo Road</ns2:street2>
                <ns2:city>Dublin 4</ns2:city>
                <ns2:stateOrCountry>L2</ns2:stateOrCountry>
                <ns2:zipCode>D04 E5W7</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>011-353-1-634-7800</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>NEENA PATIL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>1500</noOfUnitsSold>
            <aggregateMarketValue>216375.00</aggregateMarketValue>
            <noOfUnitsOutstanding>63134812</noOfUnitsOutstanding>
            <approxSaleDate>09/01/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/05/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1442</amountOfSecuritiesAcquired>
            <paymentDate>03/05/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/05/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>58</amountOfSecuritiesAcquired>
            <paymentDate>08/05/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>NEENA PATIL</name>
                <address>
                    <ns2:street1>Fifth Floor, Waterloo Exchange</ns2:street1>
                    <ns2:street2>Waterloo Road</ns2:street2>
                    <ns2:city>Dublin 4</ns2:city>
                    <ns2:stateOrCountry>L2</ns2:stateOrCountry>
                    <ns2:zipCode>D04 E5W7</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/15/2023</saleDate>
            <amountOfSecuritiesSold>750</amountOfSecuritiesSold>
            <grossProceeds>104694.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>09/01/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>06/02/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Neena M Patil</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001783908
XXXXXXXX
LIVE
0001232524
JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY
001-33500
Fifth Floor, Waterloo Exchange
Waterloo Road
Dublin 4
L2
D04 E5W7
011-353-1-634-7800
NEENA PATIL
Officer
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
1500
216375.00
63134812
09/01/2023
NASDAQ
Common
03/05/2023
Restricted Stock
Issuer
N
1442
03/05/2023
Not Applicable
Common
08/05/2022
Restricted Stock
Issuer
N
58
08/05/2022
Not Applicable
N
NEENA PATIL
Fifth Floor, Waterloo Exchange
Waterloo Road
Dublin 4
L2
D04 E5W7
Common
08/15/2023
750
104694.00
09/01/2023
06/02/2023
/s/ Neena M Patil