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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001840706</issuerCik>
            <issuerName>SOPHIA GENETICS SA</issuerName>
            <secFileNumber>001-40627</secFileNumber>
            <issuerAddress>
                <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                <ns2:city>Rolle</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41216941060</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PHILIPPE MENU</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>7148</noOfUnitsSold>
            <aggregateMarketValue>21158.08</aggregateMarketValue>
            <noOfUnitsOutstanding>66687085</noOfUnitsOutstanding>
            <approxSaleDate>05/19/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/18/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7148</amountOfSecuritiesAcquired>
            <paymentDate>05/18/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/23/2025</saleDate>
            <amountOfSecuritiesSold>104</amountOfSecuritiesSold>
            <grossProceeds>314.91</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
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                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/21/2025</saleDate>
            <amountOfSecuritiesSold>609</amountOfSecuritiesSold>
            <grossProceeds>1660.44</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/09/2025</saleDate>
            <amountOfSecuritiesSold>3916</amountOfSecuritiesSold>
            <grossProceeds>10975.37</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/08/2025</saleDate>
            <amountOfSecuritiesSold>1873</amountOfSecuritiesSold>
            <grossProceeds>5174.72</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/07/2025</saleDate>
            <amountOfSecuritiesSold>1857</amountOfSecuritiesSold>
            <grossProceeds>4974.53</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/04/2025</saleDate>
            <amountOfSecuritiesSold>1512</amountOfSecuritiesSold>
            <grossProceeds>4158.60</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/03/2025</saleDate>
            <amountOfSecuritiesSold>654</amountOfSecuritiesSold>
            <grossProceeds>1994.31</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/24/2025</saleDate>
            <amountOfSecuritiesSold>105</amountOfSecuritiesSold>
            <grossProceeds>326.55</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/19/2025</saleDate>
            <amountOfSecuritiesSold>608</amountOfSecuritiesSold>
            <grossProceeds>1857.93</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/24/2025</saleDate>
            <amountOfSecuritiesSold>104</amountOfSecuritiesSold>
            <grossProceeds>426.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PHILIPPE MENU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/20/2025</saleDate>
            <amountOfSecuritiesSold>3995</amountOfSecuritiesSold>
            <grossProceeds>19586.69</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 05/18/2025 through 07/22/2025.
</remarks>
        <noticeSignature>
            <noticeDate>05/19/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/09/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Phillippe Menu</signature>
        </noticeSignature>
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144
0002014308
XXXXXXXX
LIVE
0001840706
SOPHIA GENETICS SA
001-40627
La Piece 12 ch-1180
Rolle
V8
00000
41216941060
PHILIPPE MENU
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
7148
21158.08
66687085
05/19/2025
NASDAQ
Common
05/18/2025
Restricted Stock Units
Issuer
N
7148
05/18/2025
N/A
N
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/23/2025
104
314.91
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/21/2025
609
1660.44
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/09/2025
3916
10975.37
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/08/2025
1873
5174.72
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/07/2025
1857
4974.53
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/04/2025
1512
4158.60
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/03/2025
654
1994.31
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
03/24/2025
105
326.55
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
03/19/2025
608
1857.93
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
02/24/2025
104
426.40
10b5-1 Sales for PHILIPPE MENU
La Piece 12 ch-1180
Rolle
V8
00000
Common
02/20/2025
3995
19586.69
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 05/18/2025 through 07/22/2025.
05/19/2025
09/09/2024
/s/ Phillippe Menu