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                <filerCredentials>
                    <cik>0001588334</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001048695</issuerCik>
            <issuerName>F5, INC.</issuerName>
            <secFileNumber>000-26041</secFileNumber>
            <issuerAddress>
                <ns2:street1>801 5TH AVENUE</ns2:street1>
                <ns2:city>Seattle</ns2:city>
                <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                <ns2:zipCode>98104</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>206-272-5555</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SCOT FRAZIER ROGERS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2955</noOfUnitsSold>
            <aggregateMarketValue>781715.70</aggregateMarketValue>
            <noOfUnitsOutstanding>57919000</noOfUnitsOutstanding>
            <approxSaleDate>05/01/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/01/2019</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>697</amountOfSecuritiesAcquired>
            <paymentDate>05/01/2019</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/01/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>455</amountOfSecuritiesAcquired>
            <paymentDate>05/01/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/01/2019</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>700</amountOfSecuritiesAcquired>
            <paymentDate>02/01/2019</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/01/2019</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>95</amountOfSecuritiesAcquired>
            <paymentDate>08/01/2019</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/01/2018</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1008</amountOfSecuritiesAcquired>
            <paymentDate>05/01/2018</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SCOT FRAZIER ROGERS</name>
                <address>
                    <ns2:street1>801 5TH AVENUE</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/26/2025</saleDate>
            <amountOfSecuritiesSold>283</amountOfSecuritiesSold>
            <grossProceeds>82969.94</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SCOT FRAZIER ROGERS</name>
                <address>
                    <ns2:street1>801 5TH AVENUE</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/26/2025</saleDate>
            <amountOfSecuritiesSold>703</amountOfSecuritiesSold>
            <grossProceeds>206105.54</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SCOT FRAZIER ROGERS</name>
                <address>
                    <ns2:street1>801 5TH AVENUE</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/26/2025</saleDate>
            <amountOfSecuritiesSold>936</amountOfSecuritiesSold>
            <grossProceeds>274416.48</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SCOT FRAZIER ROGERS</name>
                <address>
                    <ns2:street1>801 5TH AVENUE</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/26/2025</saleDate>
            <amountOfSecuritiesSold>122</amountOfSecuritiesSold>
            <grossProceeds>35767.96</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SCOT FRAZIER ROGERS</name>
                <address>
                    <ns2:street1>801 5TH AVENUE</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/26/2025</saleDate>
            <amountOfSecuritiesSold>103</amountOfSecuritiesSold>
            <grossProceeds>30197.54</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SCOT FRAZIER ROGERS</name>
                <address>
                    <ns2:street1>801 5TH AVENUE</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/26/2025</saleDate>
            <amountOfSecuritiesSold>1173</amountOfSecuritiesSold>
            <grossProceeds>343900.14</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SCOT FRAZIER ROGERS</name>
                <address>
                    <ns2:street1>801 5TH AVENUE</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/26/2025</saleDate>
            <amountOfSecuritiesSold>166</amountOfSecuritiesSold>
            <grossProceeds>48667.88</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/01/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/27/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Scot F. Rogers</signature>
        </noticeSignature>
    </formData>
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144
0001588334
XXXXXXXX
LIVE
0001048695
F5, INC.
000-26041
801 5TH AVENUE
Seattle
WA
98104
206-272-5555
SCOT FRAZIER ROGERS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
2955
781715.70
57919000
05/01/2025
NASDAQ
Common
05/01/2019
Restricted Stock
ISSUER
N
697
05/01/2019
Not Applicable
Common
05/01/2024
Restricted Stock
ISSUER
N
455
05/01/2024
Not Applicable
Common
02/01/2019
Restricted Stock
ISSUER
N
700
02/01/2019
Not Applicable
Common
08/01/2019
Restricted Stock
ISSUER
N
95
08/01/2019
Not Applicable
Common
05/01/2018
Restricted Stock
ISSUER
N
1008
05/01/2018
Not Applicable
N
SCOT FRAZIER ROGERS
801 5TH AVENUE
Seattle
WA
98104
Common
02/26/2025
283
82969.94
SCOT FRAZIER ROGERS
801 5TH AVENUE
Seattle
WA
98104
Common
02/26/2025
703
206105.54
SCOT FRAZIER ROGERS
801 5TH AVENUE
Seattle
WA
98104
Common
02/26/2025
936
274416.48
SCOT FRAZIER ROGERS
801 5TH AVENUE
Seattle
WA
98104
Common
02/26/2025
122
35767.96
SCOT FRAZIER ROGERS
801 5TH AVENUE
Seattle
WA
98104
Common
02/26/2025
103
30197.54
SCOT FRAZIER ROGERS
801 5TH AVENUE
Seattle
WA
98104
Common
02/26/2025
1173
343900.14
SCOT FRAZIER ROGERS
801 5TH AVENUE
Seattle
WA
98104
Common
02/26/2025
166
48667.88
05/01/2025
11/27/2024
/s/ Scot F. Rogers