<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001961477</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
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    <issuerInfo>
      <issuerCik>0001468929</issuerCik>
      <issuerName>NEXGEL, INC.</issuerName>
      <secFileNumber>001-41173</secFileNumber>
      <issuerAddress>
        <com:street1>2150 CABOT BLVD WEST,</com:street1>
        <com:street2>SUITE B</com:street2>
        <com:city>LANGHORNE</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>19047</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>215 702-8550</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Henry Scott Robert</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>THE CHARLES SCHWAB CORPORATION</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>9000</noOfUnitsSold>
      <aggregateMarketValue>23400.00</aggregateMarketValue>
      <noOfUnitsOutstanding>7654037</noOfUnitsOutstanding>
      <approxSaleDate>04/10/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>09/15/2022</acquiredDate>
      <natureOfAcquisitionTransaction>OPEN MARKET PURCHASES</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>OPEN MARKET</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>9000</amountOfSecuritiesAcquired>
      <paymentDate>09/15/2022</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>SCOTT ROBERT HENRY</name>
        <address>
          <com:street1>2150 Cabot Blvd West,</com:street1>
          <com:street2>Suite B</com:street2>
          <com:city>Langhorne</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19047</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>02/10/2025</saleDate>
      <amountOfSecuritiesSold>3000</amountOfSecuritiesSold>
      <grossProceeds>9798.30</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>SCOTT ROBERT HENRY</name>
        <address>
          <com:street1>2150 Cabot Blvd West,</com:street1>
          <com:street2>Suite B</com:street2>
          <com:city>Langhorne</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19047</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>03/10/2025</saleDate>
      <amountOfSecuritiesSold>3000</amountOfSecuritiesSold>
      <grossProceeds>8621.10</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>SHARES ACQUIRED VIA OPEN MARKET PURCHASE BETWEEN 9/15/22 - 9/26/22</remarks>
    <noticeSignature>
      <noticeDate>04/10/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>09/20/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>SCOTT ROBERT HENRY</signature>
    </noticeSignature>
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144
0001961477
XXXXXXXX
LIVE
0001468929
NEXGEL, INC.
001-41173
2150 CABOT BLVD WEST,
SUITE B
LANGHORNE
PA
19047
215 702-8550
Henry Scott Robert
Director
COMMON
THE CHARLES SCHWAB CORPORATION
3000 Schwab Way
Westlake
TX
76262
9000
23400.00
7654037
04/10/2025
NASDAQ
COMMON
09/15/2022
OPEN MARKET PURCHASES
OPEN MARKET
N
9000
09/15/2022
NA
N
SCOTT ROBERT HENRY
2150 Cabot Blvd West,
Suite B
Langhorne
PA
19047
COMMON
02/10/2025
3000
9798.30
SCOTT ROBERT HENRY
2150 Cabot Blvd West,
Suite B
Langhorne
PA
19047
COMMON
03/10/2025
3000
8621.10
SHARES ACQUIRED VIA OPEN MARKET PURCHASE BETWEEN 9/15/22 - 9/26/22
04/10/2025
09/20/2024
SCOTT ROBERT HENRY