<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001195340</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001039065</issuerCik>
            <issuerName>OSI SYSTEMS INC</issuerName>
            <secFileNumber>000-23125</secFileNumber>
            <issuerAddress>
                <ns2:street1>12525 Chadron Avenue</ns2:street1>
                <ns2:city>Hawthorne</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>90250</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>310-978-0516</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ALAN I EDRICK</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>13696</noOfUnitsSold>
            <aggregateMarketValue>1952285.36</aggregateMarketValue>
            <noOfUnitsOutstanding>17048704</noOfUnitsOutstanding>
            <approxSaleDate>06/05/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>08/24/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5875</amountOfSecuritiesAcquired>
            <paymentDate>08/24/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>09/20/2017</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7821</amountOfSecuritiesAcquired>
            <paymentDate>09/20/2017</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ALAN I EDRICK</name>
                <address>
                    <ns2:street1>12525 Chadron Avenue</ns2:street1>
                    <ns2:city>Hawthorne</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>90250</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/03/2024</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>3592500.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ALAN I EDRICK</name>
                <address>
                    <ns2:street1>12525 Chadron Avenue</ns2:street1>
                    <ns2:city>Hawthorne</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>90250</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/03/2024</saleDate>
            <amountOfSecuritiesSold>5386</amountOfSecuritiesSold>
            <grossProceeds>775584.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ALAN I EDRICK</name>
                <address>
                    <ns2:street1>12525 Chadron Avenue</ns2:street1>
                    <ns2:city>Hawthorne</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>90250</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/28/2024</saleDate>
            <amountOfSecuritiesSold>4216</amountOfSecuritiesSold>
            <grossProceeds>599271.94</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/05/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Alan Edrick</signature>
        </noticeSignature>
    </formData>
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144
0001195340
XXXXXXXX
LIVE
0001039065
OSI SYSTEMS INC
000-23125
12525 Chadron Avenue
Hawthorne
CA
90250
310-978-0516
ALAN I EDRICK
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
13696
1952285.36
17048704
06/05/2024
NASDAQ
COMMON
08/24/2022
Restricted stock vesting under a registered plan
Issuer
N
5875
08/24/2022
Not Applicable
COMMON
09/20/2017
Restricted stock vesting under a registered plan
Issuer
N
7821
09/20/2017
Not Applicable
N
ALAN I EDRICK
12525 Chadron Avenue
Hawthorne
CA
90250
Common
06/03/2024
25000
3592500.00
ALAN I EDRICK
12525 Chadron Avenue
Hawthorne
CA
90250
Common
06/03/2024
5386
775584.00
ALAN I EDRICK
12525 Chadron Avenue
Hawthorne
CA
90250
Common
05/28/2024
4216
599271.94
06/05/2024
/s/ Alan Edrick