<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001321402</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001437402</issuerCik>
            <issuerName>ARDELYX, INC.</issuerName>
            <secFileNumber>001-36485</secFileNumber>
            <issuerAddress>
                <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02451</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 745-1700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MICHAEL G. RAAB</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2743</noOfUnitsSold>
            <aggregateMarketValue>13440.70</aggregateMarketValue>
            <noOfUnitsOutstanding>236854270</noOfUnitsOutstanding>
            <approxSaleDate>11/11/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/28/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2743</amountOfSecuritiesAcquired>
            <paymentDate>02/28/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL G. RAAB</name>
                <address>
                    <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/11/2024</saleDate>
            <amountOfSecuritiesSold>2743</amountOfSecuritiesSold>
            <grossProceeds>13440.70</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL G. RAAB</name>
                <address>
                    <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/28/2024</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>147740.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL G. RAAB</name>
                <address>
                    <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/11/2024</saleDate>
            <amountOfSecuritiesSold>7500</amountOfSecuritiesSold>
            <grossProceeds>45075.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL G. RAAB</name>
                <address>
                    <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/26/2024</saleDate>
            <amountOfSecuritiesSold>3000</amountOfSecuritiesSold>
            <grossProceeds>18210.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL G. RAAB</name>
                <address>
                    <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/11/2024</saleDate>
            <amountOfSecuritiesSold>35000</amountOfSecuritiesSold>
            <grossProceeds>196399.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL G. RAAB</name>
                <address>
                    <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/27/2024</saleDate>
            <amountOfSecuritiesSold>7500</amountOfSecuritiesSold>
            <grossProceeds>46635.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL G. RAAB</name>
                <address>
                    <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/20/2024</saleDate>
            <amountOfSecuritiesSold>32225</amountOfSecuritiesSold>
            <grossProceeds>188847.94</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings November 11, 2024 in observance of the federal holiday.  </remarks>
        <noticeSignature>
            <noticeDate>11/12/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/13/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Michael George Raab</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 8526}]
144
0001321402
XXXXXXXX
LIVE
0001437402
ARDELYX, INC.
001-36485
400 Fifth Avenue, Suite 210
Waltham
MA
02451
(510) 745-1700
MICHAEL G. RAAB
Officer
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
2743
13440.70
236854270
11/11/2024
NASDAQ
Common
02/28/2021
Employee Stock Purchase Plan
Issuer
N
2743
02/28/2021
Cash
N
MICHAEL G. RAAB
400 Fifth Avenue, Suite 210
Waltham
MA
02451
Common
11/11/2024
2743
13440.70
MICHAEL G. RAAB
400 Fifth Avenue, Suite 210
Waltham
MA
02451
Common
10/28/2024
25000
147740.00
MICHAEL G. RAAB
400 Fifth Avenue, Suite 210
Waltham
MA
02451
Common
10/11/2024
7500
45075.00
MICHAEL G. RAAB
400 Fifth Avenue, Suite 210
Waltham
MA
02451
Common
09/26/2024
3000
18210.00
MICHAEL G. RAAB
400 Fifth Avenue, Suite 210
Waltham
MA
02451
Common
09/11/2024
35000
196399.00
MICHAEL G. RAAB
400 Fifth Avenue, Suite 210
Waltham
MA
02451
Common
08/27/2024
7500
46635.00
MICHAEL G. RAAB
400 Fifth Avenue, Suite 210
Waltham
MA
02451
Common
08/20/2024
32225
188847.94
Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings November 11, 2024 in observance of the federal holiday.
11/12/2024
12/13/2023
/s/ Michael George Raab