<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001870610</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
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    <formData>
        <issuerInfo>
            <issuerCik>0001484612</issuerCik>
            <issuerName>OUTSET MEDICAL, INC.</issuerName>
            <secFileNumber>001-39513</secFileNumber>
            <issuerAddress>
                <ns2:street1>3052 ORCHARD DRIVE</ns2:street1>
                <ns2:city>SAN JOSE</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>95134</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(669) 231-8200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>NABEEL AHMED</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>990</noOfUnitsSold>
            <aggregateMarketValue>20621.70</aggregateMarketValue>
            <noOfUnitsOutstanding>49228078</noOfUnitsOutstanding>
            <approxSaleDate>06/01/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>08/05/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>190</amountOfSecuritiesAcquired>
            <paymentDate>08/05/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>01/26/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>700</amountOfSecuritiesAcquired>
            <paymentDate>01/26/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>03/08/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>100</amountOfSecuritiesAcquired>
            <paymentDate>03/08/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>NABEEL AHMED</name>
                <address>
                    <ns2:street1>3052 ORCHARD DRIVE</ns2:street1>
                    <ns2:city>SAN JOSE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95134</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>05/16/2023</saleDate>
            <amountOfSecuritiesSold>1532</amountOfSecuritiesSold>
            <grossProceeds>30471.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>NABEEL AHMED</name>
                <address>
                    <ns2:street1>3052 ORCHARD DRIVE</ns2:street1>
                    <ns2:city>SAN JOSE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95134</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/03/2023</saleDate>
            <amountOfSecuritiesSold>990</amountOfSecuritiesSold>
            <grossProceeds>19800.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/01/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/17/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Nabeel Syed Ahmed</signature>
        </noticeSignature>
    </formData>
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144
0001870610
XXXXXXXX
LIVE
0001484612
OUTSET MEDICAL, INC.
001-39513
3052 ORCHARD DRIVE
SAN JOSE
CA
95134
(669) 231-8200
NABEEL AHMED
Officer
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
990
20621.70
49228078
06/01/2023
NASD
COMMON
08/05/2022
Restricted Stock
ISSUER
N
190
08/05/2022
Not Applicable
COMMON
01/26/2023
Restricted Stock
ISSUER
N
700
01/26/2023
Not Applicable
COMMON
03/08/2022
Restricted Stock
ISSUER
N
100
03/08/2022
Not Applicable
N
NABEEL AHMED
3052 ORCHARD DRIVE
SAN JOSE
CA
95134
common
05/16/2023
1532
30471.00
NABEEL AHMED
3052 ORCHARD DRIVE
SAN JOSE
CA
95134
Common
05/03/2023
990
19800.00
06/01/2023
02/17/2023
/s/ Nabeel Syed Ahmed