<?xml version="1.0" encoding="UTF-8"?><ns2:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:ns2="http://www.sec.gov/edgar/ownership">
    <ns2:headerData>
        <ns2:submissionType>144</ns2:submissionType>
        <ns2:filerInfo>
            <ns2:filer>
                <ns2:filerCredentials>
                    <ns2:cik>0001422996</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
                </ns2:filerCredentials>
            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



        </ns2:filerInfo>
    </ns2:headerData>
    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0001724521</ns2:issuerCik>
            <ns2:issuerName>Arcus Biosciences, Inc.</ns2:issuerName>
            <ns2:secFileNumber>001-38419</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>3928 Point Eden Way</com:street1>
                <com:city>Hayward</com:city>
                <com:stateOrCountry>CA</com:stateOrCountry>
                <com:zipCode>94545</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>1-510-694-6200</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Juan Jaen</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Officer</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>Class A Common Stock</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>100000</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>1968000</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>74855565</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>01/02/2024</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NYSE</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Class A Common Stock</ns2:securitiesClassTitle>
            <ns2:acquiredDate>05/08/2015</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from issuer in private transaction</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>The issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>100000</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>05/08/2015</ns2:paymentDate>
            <ns2:natureOfPayment>None</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:remarks>The sales of shares set forth herein are made in connection with a selling plan dated 08-Aug-2023 that is intended to comply with Rule 10b5-1(c).</ns2:remarks>
        <ns2:noticeSignature>
            <ns2:noticeDate>01/02/2024</ns2:noticeDate>
            <ns2:planAdoptionDates>
                <ns2:planAdoptionDate>08/08/2023</ns2:planAdoptionDate>
            </ns2:planAdoptionDates>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of Juan Jaen</ns2:signature>
        </ns2:noticeSignature>
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144
0001422996
XXXXXXXX
LIVE
0001724521
Arcus Biosciences, Inc.
001-38419
3928 Point Eden Way
Hayward
CA
94545
1-510-694-6200
Juan Jaen
Officer
Class A Common Stock
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
100000
1968000
74855565
01/02/2024
NYSE
Class A Common Stock
05/08/2015
Acquired from issuer in private transaction
The issuer
N
100000
05/08/2015
None
Y
The sales of shares set forth herein are made in connection with a selling plan dated 08-Aug-2023 that is intended to comply with Rule 10b5-1(c).
01/02/2024
08/08/2023
Goldman Sachs & Co. LLC on behalf of Juan Jaen