<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
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            <filer>
                <filerCredentials>
                    <cik>0001466562</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
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    <formData>
        <issuerInfo>
            <issuerCik>0001437402</issuerCik>
            <issuerName>ARDELYX, INC.</issuerName>
            <secFileNumber>001-36485</secFileNumber>
            <issuerAddress>
                <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02451</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 745-1700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JUSTIN ANDREW RENZ</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>225000</noOfUnitsSold>
            <aggregateMarketValue>1430130.00</aggregateMarketValue>
            <noOfUnitsOutstanding>232137709</noOfUnitsOutstanding>
            <approxSaleDate>12/26/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/26/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>75000</amountOfSecuritiesAcquired>
            <paymentDate>12/26/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/01/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>150000</amountOfSecuritiesAcquired>
            <paymentDate>06/01/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JUSTIN ANDREW RENZ</name>
                <address>
                    <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/20/2023</saleDate>
            <amountOfSecuritiesSold>2873</amountOfSecuritiesSold>
            <grossProceeds>12533.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>12/26/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/12/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Justin Renz</signature>
        </noticeSignature>
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144
0001466562
XXXXXXXX
LIVE
0001437402
ARDELYX, INC.
001-36485
400 Fifth Avenue, Suite 210
Waltham
MA
02451
(510) 745-1700
JUSTIN ANDREW RENZ
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
225000
1430130.00
232137709
12/26/2023
NASDAQ
Common
12/26/2023
Stock Option Exercise
Issuer
N
75000
12/26/2023
Cash
Common
06/01/2022
Restricted Stock
Issuer
N
150000
06/01/2022
Not Applicable
N
JUSTIN ANDREW RENZ
400 Fifth Avenue, Suite 210
Waltham
MA
02451
Common
11/20/2023
2873
12533.00
12/26/2023
09/12/2023
/s/ Justin Renz