<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001817217</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001549595</issuerCik>
            <issuerName>NURIX THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-39398</secFileNumber>
            <issuerAddress>
                <ns2:street1>1700 Owens Street, Suite 205</ns2:street1>
                <ns2:city>San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94158</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>4156605320</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JOHANNES VAN HOUTE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>6198</noOfUnitsSold>
            <aggregateMarketValue>69169.68</aggregateMarketValue>
            <noOfUnitsOutstanding>76235594</noOfUnitsOutstanding>
            <approxSaleDate>05/02/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>04/30/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6198</amountOfSecuritiesAcquired>
            <paymentDate>04/30/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JOHANNES VAN HOUTE</name>
                <address>
                    <ns2:street1>1700 Owens Street, Suite 205</ns2:street1>
                    <ns2:city>San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94158</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/30/2025</saleDate>
            <amountOfSecuritiesSold>2438</amountOfSecuritiesSold>
            <grossProceeds>28041.14</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JOHANNES VAN HOUTE</name>
                <address>
                    <ns2:street1>1700 Owens Street, Suite 205</ns2:street1>
                    <ns2:city>San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94158</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/03/2025</saleDate>
            <amountOfSecuritiesSold>5825</amountOfSecuritiesSold>
            <grossProceeds>84387.36</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/02/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/12/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Johannes van Houte</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4757}]
144
0001817217
XXXXXXXX
LIVE
0001549595
NURIX THERAPEUTICS, INC.
001-39398
1700 Owens Street, Suite 205
San Francisco
CA
94158
4156605320
JOHANNES VAN HOUTE
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
6198
69169.68
76235594
05/02/2025
NASDAQ
Common
04/30/2025
Restricted Stock Units
Issuer
N
6198
04/30/2025
N/A
N
JOHANNES VAN HOUTE
1700 Owens Street, Suite 205
San Francisco
CA
94158
Common
04/30/2025
2438
28041.14
10b5-1 Sales for JOHANNES VAN HOUTE
1700 Owens Street, Suite 205
San Francisco
CA
94158
Common
03/03/2025
5825
84387.36
05/02/2025
11/12/2024
/s/ Johannes van Houte