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                    <com:stateOrCountry>TX</com:stateOrCountry>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
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                    <com:stateOrCountry>TX</com:stateOrCountry>
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            <ns2:grossProceeds>33722.42</ns2:grossProceeds>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
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        <ns2:remarks>Total number of shares to be sold includes 30,000 shares by BioBrit, LLC, 10,000 shares by The Daniel M. Bradbury Irrevocable Descendants Trust, 10,000 shares by The Annette E. Bradbury
Irrevocable Descendants Trust. The sales set forth herein are made in connection with a selling plan dated 11/23/2022, that is intended to comply with Rule 105-1 (c).</ns2:remarks>
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            <ns2:noticeDate>05/04/2023</ns2:noticeDate>
            <ns2:planAdoptionDates>
                <ns2:planAdoptionDate>11/23/2022</ns2:planAdoptionDate>
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            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of Daniel M. Bradbury</ns2:signature>
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144
0001236397
XXXXXXXX
LIVE
0001447362
Castle Biosciences, Inc.
001-38984
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
1-602-535-1997
Daniel Bradbury
Affiliate
Common
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
50000
1100500
26575616
05/04/2023
NASD
Common
12/08/2020
Acquired as a gift
Daniel M. Bradbury
Y
08/12/2014
10000
12/08/2020
N/A
Common
12/08/2020
Acquired as a gift
Daniel M. Bradbury
Y
08/12/2014
10000
12/08/2020
N/A
Common
08/24/2018
Acquired as consideration of merger or acquisition
Issuer
N
1647
08/24/2018
Cash
Common
09/28/2018
Acquired as consideration of merger or acquisition
Issuer
N
1465
09/28/2018
Cash
Common
01/03/2018
Acquired from issuer in private transaction
Issuer
N
26888
01/03/2018
N/A
N
The Daniel M. Bradbury Irrevocable Descendants Trust
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
03/02/2023
2270
52887.6
The Annette E. Bradbury Irrevocable Descendants Trust
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
03/02/2023
2270
52887.6
BioBrit, LLC
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
03/02/2023
6809
158639.49
The Daniel M. Bradbury Irrevocable Descendants Trust
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
04/03/2023
2060
45598.72
The Annette E. Bradbury Irrevocable Descendants Trust
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
04/03/2023
2060
45598.72
BioBrit, LLC
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
04/03/2023
6180
136796.15
The Daniel M. Bradbury Irrevocable Descendants Trust
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
04/05/2023
1420
31521.73
The Annette E. Bradbury Irrevocable Descendants Trust
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
04/05/2023
1420
31521.73
BioBrit, LLC
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
04/05/2023
4260
94565.18
The Daniel M. Bradbury Irrevocable Descendants Trust
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
04/04/2023
1520
33722.42
The Annette E. Bradbury Irrevocable Descendants Trust
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
04/04/2023
1520
33722.42
BioBrit, LLC
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
04/04/2023
4560
101167.25
The Daniel M. Bradbury Irrevocable Descendants Trust
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
03/03/2023
2730
66966.35
The Annette E. Bradbury Irrevocable Descendants Trust
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
03/03/2023
2730
66966.35
BioBrit, LLC
820 S FRIENDSWOOD DR
SUITE 201
FRIENDSWOOD
TX
77546
Common
03/03/2023
8191
200923.59
Total number of shares to be sold includes 30,000 shares by BioBrit, LLC, 10,000 shares by The Daniel M. Bradbury Irrevocable Descendants Trust, 10,000 shares by The Annette E. Bradbury
Irrevocable Descendants Trust. The sales set forth herein are made in connection with a selling plan dated 11/23/2022, that is intended to comply with Rule 105-1 (c).
05/04/2023
11/23/2022
Goldman Sachs & Co. LLC on behalf of Daniel M. Bradbury