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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001832571</cik>
                    <ccc>XXXXXXXX</ccc>
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            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001551152</issuerCik>
            <issuerName>ABBVIE INC.</issuerName>
            <secFileNumber>001-35565</secFileNumber>
            <issuerAddress>
                <ns2:street1>1 North Waukegan Road</ns2:street1>
                <ns2:city>North Chicago</ns2:city>
                <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                <ns2:zipCode>60064</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>847-932-7900</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ELAINE SORG</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>6130</noOfUnitsSold>
            <aggregateMarketValue>1011486.78</aggregateMarketValue>
            <noOfUnitsOutstanding>1764141787</noOfUnitsOutstanding>
            <approxSaleDate>04/25/2023</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>04/25/2023</acquiredDate>
            <natureOfAcquisitionTransaction>STOCK OPTIONS</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6130</amountOfSecuritiesAcquired>
            <paymentDate>04/25/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ELAINE SORG</name>
                <address>
                    <ns2:street1>1 North Waukegan Road</ns2:street1>
                    <ns2:city>North Chicago</ns2:city>
                    <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                    <ns2:zipCode>60064</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/17/2023</saleDate>
            <amountOfSecuritiesSold>7499</amountOfSecuritiesSold>
            <grossProceeds>1212344.58</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ELAINE SORG</name>
                <address>
                    <ns2:street1>1 North Waukegan Road</ns2:street1>
                    <ns2:city>North Chicago</ns2:city>
                    <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                    <ns2:zipCode>60064</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>04/03/2023</saleDate>
            <amountOfSecuritiesSold>15002</amountOfSecuritiesSold>
            <grossProceeds>2400750.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ELAINE SORG</name>
                <address>
                    <ns2:street1>1 North Waukegan Road</ns2:street1>
                    <ns2:city>North Chicago</ns2:city>
                    <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                    <ns2:zipCode>60064</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>03/01/2023</saleDate>
            <amountOfSecuritiesSold>15003</amountOfSecuritiesSold>
            <grossProceeds>2325446.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ELAINE SORG</name>
                <address>
                    <ns2:street1>1 North Waukegan Road</ns2:street1>
                    <ns2:city>North Chicago</ns2:city>
                    <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                    <ns2:zipCode>60064</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>02/21/2023</saleDate>
            <amountOfSecuritiesSold>15321</amountOfSecuritiesSold>
            <grossProceeds>2314068.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/25/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/14/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>ELAINE SORG</signature>
        </noticeSignature>
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144
0001832571
XXXXXXXX
LIVE
0001551152
ABBVIE INC.
001-35565
1 North Waukegan Road
North Chicago
IL
60064
847-932-7900
ELAINE SORG
Officer
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
6130
1011486.78
1764141787
04/25/2023
NYSE
COMMON
04/25/2023
STOCK OPTIONS
ISSUER
N
6130
04/25/2023
Cash
N
ELAINE SORG
1 North Waukegan Road
North Chicago
IL
60064
Common
04/17/2023
7499
1212344.58
ELAINE SORG
1 North Waukegan Road
North Chicago
IL
60064
COMMON
04/03/2023
15002
2400750.00
ELAINE SORG
1 North Waukegan Road
North Chicago
IL
60064
COMMON
03/01/2023
15003
2325446.00
ELAINE SORG
1 North Waukegan Road
North Chicago
IL
60064
COMMON
02/21/2023
15321
2314068.00
04/25/2023
02/14/2023
ELAINE SORG