<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001808942</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001035267</issuerCik>
            <issuerName>INTUITIVE SURGICAL, INC.</issuerName>
            <secFileNumber>000-30713</secFileNumber>
            <issuerAddress>
                <ns2:street1>1020 KIFER ROAD</ns2:street1>
                <ns2:city>SUNNYVALE</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94086</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(408) 523-2100</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROBERT DESANTIS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>239</noOfUnitsSold>
            <aggregateMarketValue>129033.71</aggregateMarketValue>
            <noOfUnitsOutstanding>356179445</noOfUnitsOutstanding>
            <approxSaleDate>11/11/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/11/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>239</amountOfSecuritiesAcquired>
            <paymentDate>11/11/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT DESANTIS</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/11/2024</saleDate>
            <amountOfSecuritiesSold>239</amountOfSecuritiesSold>
            <grossProceeds>129033.71</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT DESANTIS</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/29/2024</saleDate>
            <amountOfSecuritiesSold>188</amountOfSecuritiesSold>
            <grossProceeds>95225.76</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT DESANTIS</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/28/2024</saleDate>
            <amountOfSecuritiesSold>584</amountOfSecuritiesSold>
            <grossProceeds>299977.44</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT DESANTIS</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/25/2024</saleDate>
            <amountOfSecuritiesSold>1012</amountOfSecuritiesSold>
            <grossProceeds>520168.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT DESANTIS</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/10/2024</saleDate>
            <amountOfSecuritiesSold>238</amountOfSecuritiesSold>
            <grossProceeds>113645.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT DESANTIS</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/29/2024</saleDate>
            <amountOfSecuritiesSold>188</amountOfSecuritiesSold>
            <grossProceeds>90655.48</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT DESANTIS</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/28/2024</saleDate>
            <amountOfSecuritiesSold>188</amountOfSecuritiesSold>
            <grossProceeds>90790.84</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT DESANTIS</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/26/2024</saleDate>
            <amountOfSecuritiesSold>396</amountOfSecuritiesSold>
            <grossProceeds>192804.48</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings November 11, 2024 in observance of the federal holiday. </remarks>
        <noticeSignature>
            <noticeDate>11/12/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/08/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Robert James DeSantis</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 9061}]
144
0001808942
XXXXXXXX
LIVE
0001035267
INTUITIVE SURGICAL, INC.
000-30713
1020 KIFER ROAD
SUNNYVALE
CA
94086
(408) 523-2100
ROBERT DESANTIS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
239
129033.71
356179445
11/11/2024
NASDAQ
Common
11/11/2024
Stock Option Exercise
Issuer
N
239
11/11/2024
Cash
N
ROBERT DESANTIS
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
11/11/2024
239
129033.71
ROBERT DESANTIS
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
10/29/2024
188
95225.76
ROBERT DESANTIS
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
10/28/2024
584
299977.44
ROBERT DESANTIS
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
10/25/2024
1012
520168.00
ROBERT DESANTIS
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
09/10/2024
238
113645.00
ROBERT DESANTIS
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
08/29/2024
188
90655.48
ROBERT DESANTIS
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
08/28/2024
188
90790.84
ROBERT DESANTIS
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
08/26/2024
396
192804.48
Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings November 11, 2024 in observance of the federal holiday.
11/12/2024
12/08/2023
/s/ Robert James DeSantis