<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001330269</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001035267</issuerCik>
            <issuerName>INTUITIVE SURGICAL, INC.</issuerName>
            <secFileNumber>000-30713</secFileNumber>
            <issuerAddress>
                <ns2:street1>1020 KIFER ROAD</ns2:street1>
                <ns2:city>SUNNYVALE</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94086</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(408) 523-2100</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JAMIE E SAMATH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>269</noOfUnitsSold>
            <aggregateMarketValue>145230.41</aggregateMarketValue>
            <noOfUnitsOutstanding>356179445</noOfUnitsOutstanding>
            <approxSaleDate>11/11/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/11/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>269</amountOfSecuritiesAcquired>
            <paymentDate>11/11/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JAMIE E SAMATH</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/11/2024</saleDate>
            <amountOfSecuritiesSold>269</amountOfSecuritiesSold>
            <grossProceeds>145230.41</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JAMIE E SAMATH</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/08/2024</saleDate>
            <amountOfSecuritiesSold>22903</amountOfSecuritiesSold>
            <grossProceeds>12024075.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings November 11, 2024 in observance of the federal holiday. </remarks>
        <noticeSignature>
            <noticeDate>11/12/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/06/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jamie Elmo Samath</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4926}]
144
0001330269
XXXXXXXX
LIVE
0001035267
INTUITIVE SURGICAL, INC.
000-30713
1020 KIFER ROAD
SUNNYVALE
CA
94086
(408) 523-2100
JAMIE E SAMATH
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
269
145230.41
356179445
11/11/2024
NASDAQ
Common
11/11/2024
Stock Option Exercise
Issuer
N
269
11/11/2024
Cash
N
JAMIE E SAMATH
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
11/11/2024
269
145230.41
JAMIE E SAMATH
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
11/08/2024
22903
12024075.00
Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings November 11, 2024 in observance of the federal holiday.
11/12/2024
05/06/2024
/s/ Jamie Elmo Samath