<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001711968</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001604821</issuerCik>
            <issuerName>NATERA, INC.</issuerName>
            <secFileNumber>001-37478</secFileNumber>
            <issuerAddress>
                <ns2:street1>13011 MCCALLEN PASS</ns2:street1>
                <ns2:city>Austin</ns2:city>
                <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                <ns2:zipCode>78753</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 249-9090</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEVEN CHAPMAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2578</noOfUnitsSold>
            <aggregateMarketValue>141790.00</aggregateMarketValue>
            <noOfUnitsOutstanding>114601688</noOfUnitsOutstanding>
            <approxSaleDate>08/11/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>06/27/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2578</amountOfSecuritiesAcquired>
            <paymentDate>06/27/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN CHAPMAN</name>
                <address>
                    <ns2:street1>13011 MCCALLEN PASS</ns2:street1>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/24/2023</saleDate>
            <amountOfSecuritiesSold>2578</amountOfSecuritiesSold>
            <grossProceeds>123294.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN CHAPMAN</name>
                <address>
                    <ns2:street1>13011 MCCALLEN PASS</ns2:street1>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/28/2023</saleDate>
            <amountOfSecuritiesSold>5183</amountOfSecuritiesSold>
            <grossProceeds>132543.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>08/11/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/12/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Steven Leonard Chapman</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4665}]
144
0001711968
XXXXXXXX
LIVE
0001604821
NATERA, INC.
001-37478
13011 MCCALLEN PASS
Austin
TX
78753
(650) 249-9090
STEVEN CHAPMAN
Officer
Director
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
2578
141790.00
114601688
08/11/2023
NASD
COMMON
06/27/2023
Restricted Stock
ISSUER
N
2578
06/27/2023
Not Applicable
N
STEVEN CHAPMAN
13011 MCCALLEN PASS
Austin
TX
78753
Common
07/24/2023
2578
123294.00
STEVEN CHAPMAN
13011 MCCALLEN PASS
Austin
TX
78753
Common
06/28/2023
5183
132543.00
08/11/2023
12/12/2022
/s/ Steven Leonard Chapman