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      <issuerName>GeneDx Holdings Corp.</issuerName>
      <secFileNumber>001-39482</secFileNumber>
      <issuerAddress>
        <com:street1>333 LUDLOW STREET</com:street1>
        <com:street2>NORTH TOWER, 6TH FLOOR</com:street2>
        <com:city>STAMFORD</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06902</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>888-729-1206</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>OPKO HEALTH, INC.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
      </relationshipsToIssuer>
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    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>261417</noOfUnitsSold>
      <aggregateMarketValue>6964148.00</aggregateMarketValue>
      <noOfUnitsOutstanding>26141701</noOfUnitsOutstanding>
      <approxSaleDate>06/28/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
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      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <acquiredDate>04/29/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation for Sale of GeneDX to Sema 4</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>261417</amountOfSecuritiesAcquired>
      <paymentDate>04/29/2022</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
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    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/27/2024</noticeDate>
      <signature>Adam Logal</signature>
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144
0000944809
XXXXXXXX
LIVE
0001818331
GeneDx Holdings Corp.
001-39482
333 LUDLOW STREET
NORTH TOWER, 6TH FLOOR
STAMFORD
CT
06902
888-729-1206
OPKO HEALTH, INC.
10% Stockholder
Common Stock
Charles Schwab & Co.
3000 Schwab Way
Westlake
TX
76262
261417
6964148.00
26141701
06/28/2024
NASDAQ
Class A Common Stock
04/29/2022
Compensation for Sale of GeneDX to Sema 4
Issuer
N
261417
04/29/2022
N/A
Y
06/27/2024
Adam Logal