<?xml version="1.0" encoding="UTF-8"?><ns2:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:ns2="http://www.sec.gov/edgar/ownership">
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                <ns2:filerCredentials>
                    <ns2:cik>0001844267</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
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            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



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    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0001819580</ns2:issuerCik>
            <ns2:issuerName>YATSEN HOLDING LIMITED</ns2:issuerName>
            <ns2:secFileNumber>001-39703</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>Building 35, No. 2519 East Xingang Road</com:street1>
                <com:street2>Haizhu District</com:street2>
                <com:city>Guangzhou</com:city>
                <com:stateOrCountry>F4</com:stateOrCountry>
                <com:zipCode>510330</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>86-20-3837-3543</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>HUANG JINFENG</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Director</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>American Depositary Shares (each representing 20 Class A Ordinary Shares)</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>649849</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>2248477.54</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>74377306</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>10/01/2024</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NYSE</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>American Depositary Shares (each representing 20 Class A Ordinary Shares)</ns2:securitiesClassTitle>
            <ns2:acquiredDate>09/05/2018</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from issuer in private transaction</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Yatsen Holding Limited</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>649849</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>09/05/2018</ns2:paymentDate>
            <ns2:natureOfPayment>For service rendered</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:remarks>The sales of shares set forth herein are made in connection with a selling plan dated 06/28/2024 that is intended to comply with Rule 10b5-1(c). The representation below regarding the sellers knowledge of material information was true as of the date the selling plan was entered into.</ns2:remarks>
        <ns2:noticeSignature>
            <ns2:noticeDate>10/01/2024</ns2:noticeDate>
            <ns2:planAdoptionDates>
                <ns2:planAdoptionDate>06/28/2024</ns2:planAdoptionDate>
            </ns2:planAdoptionDates>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of HUANG JINFENG</ns2:signature>
        </ns2:noticeSignature>
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144
0001844267
XXXXXXXX
LIVE
0001819580
YATSEN HOLDING LIMITED
001-39703
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
86-20-3837-3543
HUANG JINFENG
Director
American Depositary Shares (each representing 20 Class A Ordinary Shares)
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
649849
2248477.54
74377306
10/01/2024
NYSE
American Depositary Shares (each representing 20 Class A Ordinary Shares)
09/05/2018
Acquired from issuer in private transaction
Yatsen Holding Limited
N
649849
09/05/2018
For service rendered
Y
The sales of shares set forth herein are made in connection with a selling plan dated 06/28/2024 that is intended to comply with Rule 10b5-1(c). The representation below regarding the sellers knowledge of material information was true as of the date the selling plan was entered into.
10/01/2024
06/28/2024
Goldman Sachs & Co. LLC on behalf of HUANG JINFENG