<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001691265</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001923840</issuerCik>
            <issuerName>THIRD HARMONIC BIO INC</issuerName>
            <secFileNumber>001-41498</secFileNumber>
            <issuerAddress>
                <ns2:street1>1700 Montgomery Street, Suite 210</ns2:street1>
                <ns2:city>San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94111</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>2097272457</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>EDWARD CONNER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>4790</noOfUnitsSold>
            <aggregateMarketValue>62988.50</aggregateMarketValue>
            <noOfUnitsOutstanding>41097512</noOfUnitsOutstanding>
            <approxSaleDate>10/28/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>10/28/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>4790</amountOfSecuritiesAcquired>
            <paymentDate>10/28/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for EDWARD CONNER</name>
                <address>
                    <ns2:street1>1700 Montgomery Street, Suite 210</ns2:street1>
                    <ns2:city>San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94111</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/19/2024</saleDate>
            <amountOfSecuritiesSold>4790</amountOfSecuritiesSold>
            <grossProceeds>71850.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>10/28/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/27/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Edward Conner</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4275}]
144
0001691265
XXXXXXXX
LIVE
0001923840
THIRD HARMONIC BIO INC
001-41498
1700 Montgomery Street, Suite 210
San Francisco
CA
94111
2097272457
EDWARD CONNER
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
4790
62988.50
41097512
10/28/2024
NASDAQ
Common
10/28/2024
Exercise of Stock Options
Issuer
N
4790
10/28/2024
Cash
N
10b5-1 Sales for EDWARD CONNER
1700 Montgomery Street, Suite 210
San Francisco
CA
94111
Common
09/19/2024
4790
71850.00
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
10/28/2024
03/27/2024
/s/ Edward Conner