<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001237262</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001808665</issuerCik>
            <issuerName>ASSERTIO HOLDINGS, INC.</issuerName>
            <secFileNumber>001-39294</secFileNumber>
            <issuerAddress>
                <ns2:street1>100 South Saunders Road, Suite 300</ns2:street1>
                <ns2:city>Lake Forest</ns2:city>
                <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                <ns2:zipCode>60045</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(224) 419-7106</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>WILLIAM MCKEE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>22000</noOfUnitsSold>
            <aggregateMarketValue>69044.80</aggregateMarketValue>
            <noOfUnitsOutstanding>93111974</noOfUnitsOutstanding>
            <approxSaleDate>08/14/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>05/11/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>22000</amountOfSecuritiesAcquired>
            <paymentDate>05/11/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>08/14/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/15/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ William Thomas McKee</signature>
        </noticeSignature>
    </formData>
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144
0001237262
XXXXXXXX
LIVE
0001808665
ASSERTIO HOLDINGS, INC.
001-39294
100 South Saunders Road, Suite 300
Lake Forest
IL
60045
(224) 419-7106
WILLIAM MCKEE
Director
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
22000
69044.80
93111974
08/14/2023
NASDAQ
COMMON
05/11/2022
Restricted Stock
ISSUER
N
22000
05/11/2022
Not Applicable
Y
08/14/2023
05/15/2023
/s/ William Thomas McKee