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      <secFileNumber>001-36305</secFileNumber>
      <issuerAddress>
        <com:street1>2340-2348 WALSH AVENUE</com:street1>
        <com:street2>SUITE 2344</com:street2>
        <com:city>SANTA CLARA</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>95051</com:zipCode>
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      <issuerContactPhone>877-774-4211</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Douglas Murphy-Chutorian</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>CEO</relationshipToIssuer>
      </relationshipsToIssuer>
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    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>APEX CLEARING</name>
        <address>
          <com:street1>350 N ST. PAUL ST</com:street1>
          <com:street2>SUITE 300</com:street2>
          <com:city>DALLAS</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75201</com:zipCode>
        </address>
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      <noOfUnitsSold>100000</noOfUnitsSold>
      <aggregateMarketValue>6200000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>8288567</noOfUnitsOutstanding>
      <approxSaleDate>12/10/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/10/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>SEMLER SCIENTIFIC, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>180000</amountOfSecuritiesAcquired>
      <paymentDate>12/10/2024</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
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    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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        <name>Douglas Murphy-Chutorian</name>
        <address>
          <com:street1>335 Churhchill Ave.</com:street1>
          <com:city>Palo Alto</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94301</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>11/07/2024</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>1896500.00</grossProceeds>
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    <noticeSignature>
      <noticeDate>12/09/2024</noticeDate>
      <signature>/s/ Douglas Murphy-Chutorian</signature>
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144
0001594342
XXXXXXXX
LIVE
0001554859
Semler Scientific, Inc.
001-36305
2340-2348 WALSH AVENUE
SUITE 2344
SANTA CLARA
CA
95051
877-774-4211
Douglas Murphy-Chutorian
CEO
Common Stock
APEX CLEARING
350 N ST. PAUL ST
SUITE 300
DALLAS
TX
75201
100000
6200000.00
8288567
12/10/2024
NASDAQ
Common
12/10/2024
Stock Option Exercise
SEMLER SCIENTIFIC, INC.
N
180000
12/10/2024
N/A
N
Douglas Murphy-Chutorian
335 Churhchill Ave.
Palo Alto
CA
94301
Common Stock
11/07/2024
50000
1896500.00
12/09/2024
/s/ Douglas Murphy-Chutorian