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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0002006362</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001840706</issuerCik>
            <issuerName>SOPHIA GENETICS SA</issuerName>
            <secFileNumber>001-40627</secFileNumber>
            <issuerAddress>
                <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                <ns2:city>Rolle</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41216941060</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ZHENYU XU</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>6939</noOfUnitsSold>
            <aggregateMarketValue>21094.56</aggregateMarketValue>
            <noOfUnitsOutstanding>66687085</noOfUnitsOutstanding>
            <approxSaleDate>07/03/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>07/02/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6939</amountOfSecuritiesAcquired>
            <paymentDate>07/02/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/23/2025</saleDate>
            <amountOfSecuritiesSold>104</amountOfSecuritiesSold>
            <grossProceeds>314.72</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/20/2025</saleDate>
            <amountOfSecuritiesSold>608</amountOfSecuritiesSold>
            <grossProceeds>1800.84</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/23/2025</saleDate>
            <amountOfSecuritiesSold>105</amountOfSecuritiesSold>
            <grossProceeds>299.76</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/19/2025</saleDate>
            <amountOfSecuritiesSold>609</amountOfSecuritiesSold>
            <grossProceeds>1746.49</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/23/2025</saleDate>
            <amountOfSecuritiesSold>104</amountOfSecuritiesSold>
            <grossProceeds>315.09</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/21/2025</saleDate>
            <amountOfSecuritiesSold>609</amountOfSecuritiesSold>
            <grossProceeds>1661.23</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/09/2025</saleDate>
            <amountOfSecuritiesSold>3896</amountOfSecuritiesSold>
            <grossProceeds>10935.68</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/08/2025</saleDate>
            <amountOfSecuritiesSold>1875</amountOfSecuritiesSold>
            <grossProceeds>5175.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/07/2025</saleDate>
            <amountOfSecuritiesSold>1900</amountOfSecuritiesSold>
            <grossProceeds>5097.32</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ZHENYU XU</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/04/2025</saleDate>
            <amountOfSecuritiesSold>1526</amountOfSecuritiesSold>
            <grossProceeds>4197.57</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were or will be acquired upon the vesting of restricted stock units during the period of 07/02/2025 through 09/18/2025.
</remarks>
        <noticeSignature>
            <noticeDate>07/03/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/09/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Zhenyu Xu</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 10438}]
144
0002006362
XXXXXXXX
LIVE
0001840706
SOPHIA GENETICS SA
001-40627
La Piece 12 ch-1180
Rolle
V8
00000
41216941060
ZHENYU XU
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
6939
21094.56
66687085
07/03/2025
NASDAQ
Common
07/02/2025
Restricted Stock Units
Issuer
N
6939
07/02/2025
N/A
N
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
06/23/2025
104
314.72
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
06/20/2025
608
1800.84
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
05/23/2025
105
299.76
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
05/19/2025
609
1746.49
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/23/2025
104
315.09
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/21/2025
609
1661.23
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/09/2025
3896
10935.68
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/08/2025
1875
5175.00
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/07/2025
1900
5097.32
10b5-1 Sales for ZHENYU XU
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/04/2025
1526
4197.57
The securities to be sold were or will be acquired upon the vesting of restricted stock units during the period of 07/02/2025 through 09/18/2025.
07/03/2025
09/09/2024
/s/ Zhenyu Xu