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    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001919795</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001571949</issuerCik>
            <issuerName>INTERCONTINENTAL EXCHANGE, INC.</issuerName>
            <secFileNumber>001-36198</secFileNumber>
            <issuerAddress>
                <ns2:street1>5660 New Northside Drive</ns2:street1>
                <ns2:city>Atlanta</ns2:city>
                <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                <ns2:zipCode>30328</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>7708574700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CHRISTOPHER EDMONDS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>601</noOfUnitsSold>
            <aggregateMarketValue>87295.25</aggregateMarketValue>
            <noOfUnitsOutstanding>574176497</noOfUnitsOutstanding>
            <approxSaleDate>01/15/2025</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>04/04/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Previously Exercised Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>601</amountOfSecuritiesAcquired>
            <paymentDate>04/04/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CHRISTOPHER EDMONDS</name>
                <address>
                    <ns2:street1>5660 New Northside Drive</ns2:street1>
                    <ns2:city>Atlanta</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30328</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>11/13/2024</saleDate>
            <amountOfSecuritiesSold>602</amountOfSecuritiesSold>
            <grossProceeds>94411.66</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>01/15/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/04/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Christopher Edmonds</signature>
        </noticeSignature>
    </formData>
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144
0001919795
XXXXXXXX
LIVE
0001571949
INTERCONTINENTAL EXCHANGE, INC.
001-36198
5660 New Northside Drive
Atlanta
GA
30328
7708574700
CHRISTOPHER EDMONDS
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
601
87295.25
574176497
01/15/2025
NYSE
Common
04/04/2022
Previously Exercised Stock Options
Issuer
N
601
04/04/2022
Cash
N
10b5-1 Sales for CHRISTOPHER EDMONDS
5660 New Northside Drive
Atlanta
GA
30328
COMMON
11/13/2024
602
94411.66
01/15/2025
03/04/2024
/s/ Christopher Edmonds