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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001796068</cik>
                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001321732</issuerCik>
            <issuerName>PENUMBRA, INC.</issuerName>
            <secFileNumber>001-37557</secFileNumber>
            <issuerAddress>
                <ns2:street1>One Penumbra Place</ns2:street1>
                <ns2:city>Alameda</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94502</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 748-3200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>LAMBERT SHIU</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>654</noOfUnitsSold>
            <aggregateMarketValue>158928.54</aggregateMarketValue>
            <noOfUnitsOutstanding>38379199</noOfUnitsOutstanding>
            <approxSaleDate>12/02/2024</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>10/15/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>654</amountOfSecuritiesAcquired>
            <paymentDate>10/15/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>LAMBERT SHIU</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/29/2024</saleDate>
            <amountOfSecuritiesSold>473</amountOfSecuritiesSold>
            <grossProceeds>114730.88</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>LAMBERT SHIU</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/29/2024</saleDate>
            <amountOfSecuritiesSold>473</amountOfSecuritiesSold>
            <grossProceeds>114730.88</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>LAMBERT SHIU</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/29/2024</saleDate>
            <amountOfSecuritiesSold>612</amountOfSecuritiesSold>
            <grossProceeds>148446.72</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>LAMBERT SHIU</name>
                <address>
                    <ns2:street1>One Penumbra Place</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/29/2024</saleDate>
            <amountOfSecuritiesSold>240</amountOfSecuritiesSold>
            <grossProceeds>58214.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>12/02/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/29/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Lambert M Shiu</signature>
        </noticeSignature>
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144
0001796068
XXXXXXXX
LIVE
0001321732
PENUMBRA, INC.
001-37557
One Penumbra Place
Alameda
CA
94502
(510) 748-3200
LAMBERT SHIU
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
654
158928.54
38379199
12/02/2024
NYSE
Common
10/15/2022
Restricted Stock
Issuer
N
654
10/15/2022
Not Applicable
N
LAMBERT SHIU
One Penumbra Place
Alameda
CA
94502
Common
11/29/2024
473
114730.88
LAMBERT SHIU
One Penumbra Place
Alameda
CA
94502
Common
11/29/2024
473
114730.88
LAMBERT SHIU
One Penumbra Place
Alameda
CA
94502
Common
11/29/2024
612
148446.72
LAMBERT SHIU
One Penumbra Place
Alameda
CA
94502
Common
11/29/2024
240
58214.40
12/02/2024
08/29/2024
/s/ Lambert M Shiu