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            <secFileNumber>001-39219</secFileNumber>
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                <ns2:city>Redwood City</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94063</ns2:zipCode>
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            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
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        <securitiesInformation>
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                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
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            <noOfUnitsSold>10000</noOfUnitsSold>
            <aggregateMarketValue>453500.00</aggregateMarketValue>
            <noOfUnitsOutstanding>167038943</noOfUnitsOutstanding>
            <approxSaleDate>10/01/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>10/01/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
            <paymentDate>10/01/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
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        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                    <ns2:street1>700 Saginaw Drive </ns2:street1>
                    <ns2:city>Redwood City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/01/2024</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>458827.00</grossProceeds>
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                <address>
                    <ns2:street1>700 Saginaw Drive </ns2:street1>
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                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/12/2024</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
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            <sellerDetails>
                <name>10b5-1 Sales for MARK A GOLDSMITH &amp; ANNE E MIDLERCO-TTEE REBECCA EVE GOLDSMITH TRU/A DTD 12/15/2011</name>
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                    <ns2:street1>700 Saginaw Drive </ns2:street1>
                    <ns2:city>Redwood City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/12/2024</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>225059.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for J H GOLDSMITH &amp; M A GOLDSMITHCO-TTEE JONATHAN GOLDSMITH REV TRU/A/D 8/16/2023</name>
                <address>
                    <ns2:street1>700 Saginaw Drive </ns2:street1>
                    <ns2:city>Redwood City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
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        <noticeSignature>
            <noticeDate>10/01/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/01/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Mark A Goldsmith</signature>
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144
0001246842
XXXXXXXX
LIVE
0001628171
REVOLUTION MEDICINES INC
001-39219
700 Saginaw Drive
Redwood City
CA
94063
6504816801
MARK A GOLDSMITH
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
10000
453500.00
167038943
10/01/2024
NASDAQ
Common
10/01/2024
Exercise of Stock Options
Issuer
N
10000
10/01/2024
Cash
N
10b5-1 Sales for MARK A GOLDSMITH
700 Saginaw Drive
Redwood City
CA
94063
Common
08/01/2024
10000
458827.00
10b5-1 Sales for MARK A GOLDSMITH
700 Saginaw Drive
Redwood City
CA
94063
Common
07/12/2024
25000
1126205.00
10b5-1 Sales for MARK A GOLDSMITH & ANNE E MIDLERCO-TTEE REBECCA EVE GOLDSMITH TRU/A DTD 12/15/2011
700 Saginaw Drive
Redwood City
CA
94063
Common
07/12/2024
5000
225059.00
10b5-1 Sales for J H GOLDSMITH & M A GOLDSMITHCO-TTEE JONATHAN GOLDSMITH REV TRU/A/D 8/16/2023
700 Saginaw Drive
Redwood City
CA
94063
COMMON
07/12/2024
5000
225058.00
10/01/2024
12/01/2023
/s/ Mark A Goldsmith