<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001848750</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001009001</issuerCik>
      <issuerName>Cameco Corporation</issuerName>
      <secFileNumber>001-14228</secFileNumber>
      <issuerAddress>
        <com:street1>2121 11th Street West</com:street1>
        <com:city>Saskatoon</com:city>
        <com:stateOrCountry>A9</com:stateOrCountry>
        <com:zipCode>S7M 1J3</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>13063855286</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Wong Alice</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Shares</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Solium Financial Inc.</name>
        <address>
          <com:street1>1500, 800 6th Avenue SW</com:street1>
          <com:city>Calgary</com:city>
          <com:stateOrCountry>A0</com:stateOrCountry>
          <com:zipCode>T2P 3G3</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>67300</noOfUnitsSold>
      <aggregateMarketValue>3208864.00</aggregateMarketValue>
      <noOfUnitsOutstanding>434205752</noOfUnitsOutstanding>
      <approxSaleDate>04/02/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Shares</securitiesClassTitle>
      <acquiredDate>04/02/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Cameco Corporation</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>67300</amountOfSecuritiesAcquired>
      <paymentDate>04/02/2024</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>04/02/2024</noticeDate>
      <signature>Alice Wong</signature>
    </noticeSignature>
  </formData>
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144
0001848750
XXXXXXXX
LIVE
0001009001
Cameco Corporation
001-14228
2121 11th Street West
Saskatoon
A9
S7M 1J3
13063855286
Wong Alice
Officer
Common Shares
Solium Financial Inc.
1500, 800 6th Avenue SW
Calgary
A0
T2P 3G3
67300
3208864.00
434205752
04/02/2024
NYSE
Common Shares
04/02/2024
Exercise of Stock Options
Cameco Corporation
N
67300
04/02/2024
Cash
Y
04/02/2024
Alice Wong