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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerName>AEROVATE THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-40544</secFileNumber>
            <issuerAddress>
                <ns2:street1>930 Winter Street, Suite M-500</ns2:street1>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02451</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(617) 443-2400</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>HUNTER C GILLIES</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>7000</noOfUnitsSold>
            <aggregateMarketValue>181056.20</aggregateMarketValue>
            <noOfUnitsOutstanding>27668887</noOfUnitsOutstanding>
            <approxSaleDate>03/18/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>03/18/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7000</amountOfSecuritiesAcquired>
            <paymentDate>03/18/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <name>HUNTER C GILLIES</name>
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                    <ns2:street1>930 Winter Street, Suite M-500</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/07/2024</saleDate>
            <amountOfSecuritiesSold>8975</amountOfSecuritiesSold>
            <grossProceeds>219887.50</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
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                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/23/2024</saleDate>
            <amountOfSecuritiesSold>511</amountOfSecuritiesSold>
            <grossProceeds>9964.50</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
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                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/20/2024</saleDate>
            <amountOfSecuritiesSold>3489</amountOfSecuritiesSold>
            <grossProceeds>70574.45</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>HUNTER C GILLIES</name>
                <address>
                    <ns2:street1>930 Winter Street, Suite M-500</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/17/2024</saleDate>
            <amountOfSecuritiesSold>4000</amountOfSecuritiesSold>
            <grossProceeds>78000.00</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>HUNTER C GILLIES</name>
                <address>
                    <ns2:street1>930 Winter Street, Suite M-500</ns2:street1>
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                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/27/2023</saleDate>
            <amountOfSecuritiesSold>125</amountOfSecuritiesSold>
            <grossProceeds>3062.50</grossProceeds>
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        <securitiesSoldInPast3Months>
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                <name>HUNTER C GILLIES</name>
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                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
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            <saleDate>12/20/2023</saleDate>
            <amountOfSecuritiesSold>4000</amountOfSecuritiesSold>
            <grossProceeds>78000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>03/18/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>01/19/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Hunter Gillies</signature>
        </noticeSignature>
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144
0001868997
XXXXXXXX
LIVE
0001798749
AEROVATE THERAPEUTICS, INC.
001-40544
930 Winter Street, Suite M-500
Waltham
MA
02451
(617) 443-2400
HUNTER C GILLIES
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
7000
181056.20
27668887
03/18/2024
NASDAQ
COMMON
03/18/2024
Stock Option Exercise
ISSUER
N
7000
03/18/2024
Cash
N
HUNTER C GILLIES
930 Winter Street, Suite M-500
Waltham
MA
02451
Common
03/07/2024
8975
219887.50
HUNTER C GILLIES
930 Winter Street, Suite M-500
Waltham
MA
02451
Common
02/23/2024
511
9964.50
HUNTER C GILLIES
930 Winter Street, Suite M-500
Waltham
MA
02451
Common
02/20/2024
3489
70574.45
HUNTER C GILLIES
930 Winter Street, Suite M-500
Waltham
MA
02451
Common
01/17/2024
4000
78000.00
HUNTER C GILLIES
930 Winter Street, Suite M-500
Waltham
MA
02451
Common
12/27/2023
125
3062.50
HUNTER C GILLIES
930 Winter Street, Suite M-500
Waltham
MA
02451
Common
12/20/2023
4000
78000.00
03/18/2024
01/19/2023
/s/ Hunter Gillies