<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001808047</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000090498</issuerCik>
      <issuerName>SIMMONS FIRST NATIONAL CORP</issuerName>
      <secFileNumber>000-06253</secFileNumber>
      <issuerAddress>
        <com:street1>501 MAIN STREET</com:street1>
        <com:city>PINE BLUFF</com:city>
        <com:stateOrCountry>AR</com:stateOrCountry>
        <com:zipCode>71601</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>8705411000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MAKRIS GEORGE A III</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>The Charles Schwab Corporation</name>
        <address>
          <com:street1>9825 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>15626</noOfUnitsSold>
      <aggregateMarketValue>273600.00</aggregateMarketValue>
      <noOfUnitsOutstanding>125327684</noOfUnitsOutstanding>
      <approxSaleDate>04/30/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>08/23/2012</acquiredDate>
      <natureOfAcquisitionTransaction>Open Market purchases, forward stock split, dividend reinvestment</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Open market purchase, forward stock split, dividend reinvestment</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>15626</amountOfSecuritiesAcquired>
      <paymentDate>08/23/2012</paymentDate>
      <natureOfPayment>Open Market purchase, forward stock split, dividend reinvestment</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Shares obtained in the following methods: Open market purchase - 6,210 shares - various tranches from 08/23/2012 to 10/30/2015 Dividend reinvestment - 3,001 shares - various tranches from 10/02/2012 to 04/02/2014 Forward stock split - 6,415 shares - 02/08/2018</remarks>
    <noticeSignature>
      <noticeDate>04/30/2024</noticeDate>
      <signature>George A. Makris III</signature>
    </noticeSignature>
  </formData>
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144
0001808047
XXXXXXXX
LIVE
0000090498
SIMMONS FIRST NATIONAL CORP
000-06253
501 MAIN STREET
PINE BLUFF
AR
71601
8705411000
MAKRIS GEORGE A III
Officer
Common
The Charles Schwab Corporation
9825 Schwab Way
Westlake
TX
76262
15626
273600.00
125327684
04/30/2024
NASDAQ
Common
08/23/2012
Open Market purchases, forward stock split, dividend reinvestment
Open market purchase, forward stock split, dividend reinvestment
N
15626
08/23/2012
Open Market purchase, forward stock split, dividend reinvestment
Y
Shares obtained in the following methods: Open market purchase - 6,210 shares - various tranches from 08/23/2012 to 10/30/2015 Dividend reinvestment - 3,001 shares - various tranches from 10/02/2012 to 04/02/2014 Forward stock split - 6,415 shares - 02/08/2018
04/30/2024
George A. Makris III