<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001449101</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000916907</issuerCik>
      <issuerName>SOUTHERN MISSOURI BANCORP, INC.</issuerName>
      <secFileNumber>000-23406</secFileNumber>
      <issuerAddress>
        <com:street1>2991 OAK GROVE ROAD</com:street1>
        <com:city>POPLAR BLUFF</com:city>
        <com:stateOrCountry>MO</com:stateOrCountry>
        <com:zipCode>63901</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>573-778-1800</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Robison Dennis C</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab Corporation</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>3621</noOfUnitsSold>
      <aggregateMarketValue>200760.00</aggregateMarketValue>
      <noOfUnitsOutstanding>11277167</noOfUnitsOutstanding>
      <approxSaleDate>03/06/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/23/2013</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2827</amountOfSecuritiesAcquired>
      <paymentDate>03/06/2025</paymentDate>
      <natureOfPayment>Employee Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/29/2009</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>794</amountOfSecuritiesAcquired>
      <paymentDate>05/29/2009</paymentDate>
      <natureOfPayment>Employee Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>793.576 shares are being sold in the IRA account 2,827 shares are being sold in the Individual account - Acquisition date range 07.23.2013 - 09.12.2023</remarks>
    <noticeSignature>
      <noticeDate>03/06/2025</noticeDate>
      <signature>Dennis C Robison</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
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144
0001449101
XXXXXXXX
LIVE
0000916907
SOUTHERN MISSOURI BANCORP, INC.
000-23406
2991 OAK GROVE ROAD
POPLAR BLUFF
MO
63901
573-778-1800
Robison Dennis C
Director
Common
Charles Schwab Corporation
3000 Schwab Way
Westlake
TX
76262
3621
200760.00
11277167
03/06/2025
Nasdaq
Common
07/23/2013
Employee Compensation
Issuer
N
2827
03/06/2025
Employee Compensation
Common
05/29/2009
Employee Compensation
Issuer
N
794
05/29/2009
Employee Compensation
Y
793.576 shares are being sold in the IRA account 2,827 shares are being sold in the Individual account - Acquisition date range 07.23.2013 - 09.12.2023
03/06/2025
Dennis C Robison