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            <secFileNumber>001-41740</secFileNumber>
            <issuerAddress>
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                <ns2:street2>Suite 102b</ns2:street2>
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                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02453</ns2:zipCode>
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            <issuerContactPhone>6503945230</issuerContactPhone>
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            <relationshipsToIssuer>
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            <securitiesClassTitle>Common</securitiesClassTitle>
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                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
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            <aggregateMarketValue>917533.10</aggregateMarketValue>
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            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>16010</amountOfSecuritiesAcquired>
            <paymentDate>09/16/2022</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
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                    <ns2:street1>221 Crescent St., Building 17</ns2:street1>
                    <ns2:street2>Suite 102b</ns2:street2>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02453</ns2:zipCode>
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            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/04/2024</saleDate>
            <amountOfSecuritiesSold>6665</amountOfSecuritiesSold>
            <grossProceeds>316956.38</grossProceeds>
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                    <ns2:street2>Suite 102b</ns2:street2>
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                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02453</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/07/2024</saleDate>
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                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02453</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/03/2024</saleDate>
            <amountOfSecuritiesSold>5995</amountOfSecuritiesSold>
            <grossProceeds>225402.43</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>10/02/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/27/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Carl Dambkowski</signature>
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144
0001983476
XXXXXXXX
LIVE
0001974640
APOGEE THERAPEUTICS INC
001-41740
221 Crescent St., Building 17
Suite 102b
Waltham
MA
02453
6503945230
CARL DAMBKOWSKI
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
16010
917533.10
44999000
10/02/2024
NASDAQ
Common
09/16/2022
RSA
Issuer
N
16010
09/16/2022
N/A
N
10b5-1 Sales for CARL L DAMBKOWSKI
221 Crescent St., Building 17
Suite 102b
Waltham
MA
02453
Common
09/04/2024
6665
316956.38
10b5-1 Sales for CARL L DAMBKOWSKI
221 Crescent St., Building 17
Suite 102b
Waltham
MA
02453
Common
08/07/2024
7335
298317.35
10b5-1 Sales for CARL L DAMBKOWSKI
221 Crescent St., Building 17
Suite 102b
Waltham
MA
02453
Common
07/03/2024
5995
225402.43
10/02/2024
09/27/2023
/s/ Carl Dambkowski