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                <filerCredentials>
                    <cik>0001876996</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001157601</issuerCik>
            <issuerName>MADRIGAL PHARMACEUTICALS, INC.</issuerName>
            <secFileNumber>001-33277</secFileNumber>
            <issuerAddress>
                <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                <ns2:street2>Suite 200</ns2:street2>
                <ns2:city>West Conshohocken</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19428</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(267) 824-2827</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROBERT E. WALTERMIRE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>1900</noOfUnitsSold>
            <aggregateMarketValue>532000.00</aggregateMarketValue>
            <noOfUnitsOutstanding>21311526</noOfUnitsOutstanding>
            <approxSaleDate>06/14/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/14/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1900</amountOfSecuritiesAcquired>
            <paymentDate>06/14/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT E. WALTERMIRE</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/12/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>580000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT E. WALTERMIRE</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/12/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>570000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT E. WALTERMIRE</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/12/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>586000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT E. WALTERMIRE</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/21/2024</saleDate>
            <amountOfSecuritiesSold>1036</amountOfSecuritiesSold>
            <grossProceeds>239668.24</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/14/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Robert E. Waltermire</signature>
        </noticeSignature>
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144
0001876996
XXXXXXXX
LIVE
0001157601
MADRIGAL PHARMACEUTICALS, INC.
001-33277
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
(267) 824-2827
ROBERT E. WALTERMIRE
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
1900
532000.00
21311526
06/14/2024
NASDAQ
Common
06/14/2024
Stock Option Exercise
Issuer
N
1900
06/14/2024
Cash
N
ROBERT E. WALTERMIRE
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/12/2024
2000
580000.00
ROBERT E. WALTERMIRE
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/12/2024
2000
570000.00
ROBERT E. WALTERMIRE
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/12/2024
2000
586000.00
ROBERT E. WALTERMIRE
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
05/21/2024
1036
239668.24
06/14/2024
/s/ Robert E. Waltermire