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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>000-30235</secFileNumber>
            <issuerAddress>
                <ns2:street1>1851 Harbor Bay Parkway </ns2:street1>
                <ns2:city>Alameda</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94502</ns2:zipCode>
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            <issuerContactPhone>6508377000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JEFFREY J HESSEKIEL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>25000</noOfUnitsSold>
            <aggregateMarketValue>830000.00</aggregateMarketValue>
            <noOfUnitsOutstanding>285579020</noOfUnitsOutstanding>
            <approxSaleDate>11/01/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/08/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Previously Exercised Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>25000</amountOfSecuritiesAcquired>
            <paymentDate>09/08/2020</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <address>
                    <ns2:street1>1851 Harbor Bay Parkway </ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>10/28/2024</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>709692.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MSL FBO JEFFREY J HESSEKIEL</name>
                <address>
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                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>09/23/2024</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>659385.00</grossProceeds>
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                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>08/26/2024</saleDate>
            <amountOfSecuritiesSold>20000</amountOfSecuritiesSold>
            <grossProceeds>515712.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MSL FBO JEFFREY J HESSEKIEL</name>
                <address>
                    <ns2:street1>1851 Harbor Bay Parkway </ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>08/07/2024</saleDate>
            <amountOfSecuritiesSold>80000</amountOfSecuritiesSold>
            <grossProceeds>2077962.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>11/01/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/28/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jeffrey J Hessekiel</signature>
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144
0001599803
XXXXXXXX
LIVE
0000939767
EXELIXIS INC
000-30235
1851 Harbor Bay Parkway
Alameda
CA
94502
6508377000
JEFFREY J HESSEKIEL
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
25000
830000.00
285579020
11/01/2024
NASDAQ
Common
09/08/2020
Previously Exercised Options
Issuer
N
25000
09/08/2020
Cash
N
10b5-1 Sales for MSL FBO JEFFREY J HESSEKIEL
1851 Harbor Bay Parkway
Alameda
CA
94502
COMMON
10/28/2024
25000
709692.50
10b5-1 Sales for MSL FBO JEFFREY J HESSEKIEL
1851 Harbor Bay Parkway
Alameda
CA
94502
COMMON
09/23/2024
25000
659385.00
10b5-1 Sales for MSL FBO JEFFREY J HESSEKIEL
1851 Harbor Bay Parkway
Alameda
CA
94502
COMMON
08/26/2024
20000
515712.00
10b5-1 Sales for MSL FBO JEFFREY J HESSEKIEL
1851 Harbor Bay Parkway
Alameda
CA
94502
COMMON
08/07/2024
80000
2077962.00
11/01/2024
02/28/2024
/s/ Jeffrey J Hessekiel