<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001201096</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0000914475</issuerCik>
            <issuerName>NEUROCRINE BIOSCIENCES INC</issuerName>
            <secFileNumber>000-22705</secFileNumber>
            <issuerAddress>
                <ns2:street1>6027 Edgewood Bend Court</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92130</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8586177600</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KEVIN CHARLES GORMAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>146105</noOfUnitsSold>
            <aggregateMarketValue>21730196.65</aggregateMarketValue>
            <noOfUnitsOutstanding>101246911</noOfUnitsOutstanding>
            <approxSaleDate>01/27/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/27/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>146105</amountOfSecuritiesAcquired>
            <paymentDate>01/27/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>01/27/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>06/14/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Kevin Charles Gorman</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3332}]
144
0001201096
XXXXXXXX
LIVE
0000914475
NEUROCRINE BIOSCIENCES INC
000-22705
6027 Edgewood Bend Court
San Diego
CA
92130
8586177600
KEVIN CHARLES GORMAN
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
146105
21730196.65
101246911
01/27/2025
NASDAQ
Common
01/27/2025
Exercise of Stock Options
Issuer
N
146105
01/27/2025
Cash
Y
01/27/2025
06/14/2024
/s/ Kevin Charles Gorman