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      <filer>
        <filerCredentials>
          <cik>0001329557</cik>
          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



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    <issuerInfo>
      <issuerCik>0001324404</issuerCik>
      <issuerName>CF Industries Holdings, Inc.</issuerName>
      <secFileNumber>001-32597</secFileNumber>
      <issuerAddress>
        <com:street1>2375 WATERVIEW DRIVE</com:street1>
        <com:city>NORTHBROOK</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60062</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(847) 405-2400</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Barnard Douglas C</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Former Affiliate</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>4777</noOfUnitsSold>
      <aggregateMarketValue>371488.00</aggregateMarketValue>
      <noOfUnitsOutstanding>191056501</noOfUnitsOutstanding>
      <approxSaleDate>02/20/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/03/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CF INDUSTRIES HOLDINGS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>961</amountOfSecuritiesAcquired>
      <paymentDate>01/03/2024</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/04/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CF INDUSTRIES HOLDINGS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>3816</amountOfSecuritiesAcquired>
      <paymentDate>01/04/2024</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>02/20/2024</noticeDate>
      <signature>Douglas C Barnard</signature>
    </noticeSignature>
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144
0001329557
XXXXXXXX
LIVE
0001324404
CF Industries Holdings, Inc.
001-32597
2375 WATERVIEW DRIVE
NORTHBROOK
IL
60062
(847) 405-2400
Barnard Douglas C
Former Affiliate
Common
Charles Schwab & Co., Inc.
3000 Schwab Way
Westlake
TX
76262
4777
371488.00
191056501
02/20/2024
NYSE
Common
01/03/2024
Restricted Stock Lapse
CF INDUSTRIES HOLDINGS, INC.
N
961
01/03/2024
Equity Compensation
Common
01/04/2024
Restricted Stock Lapse
CF INDUSTRIES HOLDINGS, INC.
N
3816
01/04/2024
Equity Compensation
Y
02/20/2024
Douglas C Barnard