<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001657765</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001631574</issuerCik>
            <issuerName>WAVE LIFE SCIENCES LTD.</issuerName>
            <secFileNumber>001-37627</secFileNumber>
            <issuerAddress>
                <ns2:street1>7 Straits View #12-00</ns2:street1>
                <ns2:street2>Marina One East Tower</ns2:street2>
                <ns2:city>Singapore</ns2:city>
                <ns2:stateOrCountry>U0</ns2:stateOrCountry>
                <ns2:zipCode>018936</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>65 6236 3388</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KYLE MORAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>37062</noOfUnitsSold>
            <aggregateMarketValue>176131.94</aggregateMarketValue>
            <noOfUnitsOutstanding>98983261</noOfUnitsOutstanding>
            <approxSaleDate>08/23/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>02/15/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2642</amountOfSecuritiesAcquired>
            <paymentDate>02/15/2020</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>02/15/2019</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1310</amountOfSecuritiesAcquired>
            <paymentDate>02/15/2019</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>02/15/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2634</amountOfSecuritiesAcquired>
            <paymentDate>02/15/2021</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>02/15/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>19546</amountOfSecuritiesAcquired>
            <paymentDate>02/15/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>03/24/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Exercised Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10930</amountOfSecuritiesAcquired>
            <paymentDate>03/24/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>08/23/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>04/10/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Kyle Moran</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001657765
XXXXXXXX
LIVE
0001631574
WAVE LIFE SCIENCES LTD.
001-37627
7 Straits View #12-00
Marina One East Tower
Singapore
U0
018936
65 6236 3388
KYLE MORAN
Officer
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
37062
176131.94
98983261
08/23/2023
NASD
COMMON
02/15/2020
Restricted Stock
ISSUER
N
2642
02/15/2020
Not Applicable
COMMON
02/15/2019
Restricted Stock
ISSUER
N
1310
02/15/2019
Not Applicable
COMMON
02/15/2021
Restricted Stock
ISSUER
N
2634
02/15/2021
Not Applicable
COMMON
02/15/2022
Restricted Stock
ISSUER
N
19546
02/15/2022
Not Applicable
COMMON
03/24/2021
Exercised Shares
ISSUER
N
10930
03/24/2021
Cash
Y
08/23/2023
04/10/2023
/s/ Kyle Moran