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    <ns2:headerData>
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        <ns2:filerInfo>
            <ns2:filer>
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                    <ns2:cik>0001844267</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
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            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



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        <ns2:issuerInfo>
            <ns2:issuerCik>0001819580</ns2:issuerCik>
            <ns2:issuerName>YATSEN HOLDING LIMITED</ns2:issuerName>
            <ns2:secFileNumber>001-39703</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>Building 35, No. 2519 East Xingang Road</com:street1>
                <com:street2>Haizhu District</com:street2>
                <com:city>Guangzhou</com:city>
                <com:stateOrCountry>F4</com:stateOrCountry>
                <com:zipCode>510330</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>86-20-3837-3543</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>HUANG JINFENG</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Director</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
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            <ns2:securitiesClassTitle>American Depositary Shares (each representing 20 Class A Ordinary Shares)</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>617234</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>2370178.56</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>74377306</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>01/02/2025</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NYSE</ns2:securitiesExchangeName>
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            <ns2:securitiesClassTitle>American Depositary Shares (each representing 20 Class A Ordinary Shares)</ns2:securitiesClassTitle>
            <ns2:acquiredDate>09/05/2018</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from issuer in private transaction</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Yatsen Holding Limited</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>617234</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>09/05/2018</ns2:paymentDate>
            <ns2:natureOfPayment>For service rendered</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <ns2:name>SLUMDUNK HOLDING LIMITED</ns2:name>
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                    <com:street2>Haizhu District</com:street2>
                    <com:city>Guangzhou</com:city>
                    <com:stateOrCountry>F4</com:stateOrCountry>
                    <com:zipCode>510330</com:zipCode>
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            <ns2:securitiesClassTitle>American Depositary Shares (each representing 20 Class A Ordinary Shares)</ns2:securitiesClassTitle>
            <ns2:saleDate>11/14/2024</ns2:saleDate>
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                    <com:city>Guangzhou</com:city>
                    <com:stateOrCountry>F4</com:stateOrCountry>
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            <ns2:securitiesClassTitle>American Depositary Shares (each representing 20 Class A Ordinary Shares)</ns2:securitiesClassTitle>
            <ns2:saleDate>10/03/2024</ns2:saleDate>
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            <ns2:grossProceeds>54857.48</ns2:grossProceeds>
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                    <com:stateOrCountry>F4</com:stateOrCountry>
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        <ns2:remarks>The sales of shares set forth herein are made in connection with a selling plan dated 06/28/2024 that is intended to comply with Rule 10b5-1(c). The representation below regarding the sellers knowledge of material information was true as of the date the selling plan was entered into.</ns2:remarks>
        <ns2:noticeSignature>
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            <ns2:planAdoptionDates>
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            </ns2:planAdoptionDates>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of HUANG JINFENG</ns2:signature>
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</ns2:edgarSubmission>
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144
0001844267
XXXXXXXX
LIVE
0001819580
YATSEN HOLDING LIMITED
001-39703
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
86-20-3837-3543
HUANG JINFENG
Director
American Depositary Shares (each representing 20 Class A Ordinary Shares)
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
617234
2370178.56
74377306
01/02/2025
NYSE
American Depositary Shares (each representing 20 Class A Ordinary Shares)
09/05/2018
Acquired from issuer in private transaction
Yatsen Holding Limited
N
617234
09/05/2018
For service rendered
N
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/14/2024
16243
65337.47
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/03/2024
16243
54857.48
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/02/2024
16243
54789.26
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/05/2024
16243
64038.03
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/30/2024
16243
61781.87
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/23/2024
16243
59779.11
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/19/2024
16243
72596.46
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/12/2024
16243
80177.07
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/27/2024
16243
72201.76
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/17/2024
16243
76342.1
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/15/2024
16243
56176.42
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/17/2024
16243
57982.64
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/27/2024
16243
77412.51
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/24/2024
16243
59192.74
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/19/2024
16243
63951.94
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/10/2024
16243
58034.61
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/29/2024
16243
60474.31
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/26/2024
16243
77687.02
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/20/2024
16243
68157.25
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/24/2024
16243
76665.34
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/26/2024
16243
77225.72
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/07/2024
16243
62896.14
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/06/2024
16243
62814.93
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/22/2024
16243
59678.41
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/25/2024
16243
73106.49
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/03/2024
16243
77946.91
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/31/2024
16243
61721.78
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/13/2024
16243
65124.68
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/01/2024
16372
56154.32
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/11/2024
16243
80852.78
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/08/2024
16243
55377.26
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/18/2024
16243
72632.2
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/10/2024
16243
81187.39
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/09/2024
16243
54360.45
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/05/2024
16243
79148.89
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/12/2024
16243
63592.97
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
10/16/2024
16243
57584.68
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
11/21/2024
16243
72700.42
SLUMDUNK HOLDING LIMITED
Building 35, No. 2519 East Xingang Road
Haizhu District
Guangzhou
F4
510330
American Depositary Shares (each representing 20 Class A Ordinary Shares)
12/04/2024
16243
78523.53
The sales of shares set forth herein are made in connection with a selling plan dated 06/28/2024 that is intended to comply with Rule 10b5-1(c). The representation below regarding the sellers knowledge of material information was true as of the date the selling plan was entered into.
01/02/2025
06/28/2024
Goldman Sachs & Co. LLC on behalf of HUANG JINFENG