<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001578200</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001714899</issuerCik>
            <issuerName>DENALI THERAPEUTICS INC</issuerName>
            <secFileNumber>001-38311</secFileNumber>
            <issuerAddress>
                <ns2:street1>161 Oyster Point Blvd.</ns2:street1>
                <ns2:city>South San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6508668548</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>DAVID SCHENKEIN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>59441</noOfUnitsSold>
            <aggregateMarketValue>1863475.35</aggregateMarketValue>
            <noOfUnitsOutstanding>143921624</noOfUnitsOutstanding>
            <approxSaleDate>11/11/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/11/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>47165</amountOfSecuritiesAcquired>
            <paymentDate>11/11/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/02/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>12276</amountOfSecuritiesAcquired>
            <paymentDate>06/02/2022</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings November 11, 2024 in observance of the federal holiday.

The securities to be sold were acquired upon the vesting of restricted stock units during the period of 06/02/2022 through 05/30/2024.
</remarks>
        <noticeSignature>
            <noticeDate>11/11/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/12/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ David Schenkein</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001578200
XXXXXXXX
LIVE
0001714899
DENALI THERAPEUTICS INC
001-38311
161 Oyster Point Blvd.
South San Francisco
CA
94080
6508668548
DAVID SCHENKEIN
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
59441
1863475.35
143921624
11/11/2024
NASDAQ
Common
11/11/2024
Exercise of Stock Options
Issuer
N
47165
11/11/2024
Cash
Common
06/02/2022
Restricted Stock Units
Issuer
N
12276
06/02/2022
N/A
Y
Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings November 11, 2024 in observance of the federal holiday.

The securities to be sold were acquired upon the vesting of restricted stock units during the period of 06/02/2022 through 05/30/2024.
11/11/2024
08/12/2024
/s/ David Schenkein