<?xml version="1.0" encoding="UTF-8"?><ns2:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:ns2="http://www.sec.gov/edgar/ownership">
    <ns2:headerData>
        <ns2:submissionType>144</ns2:submissionType>
        <ns2:filerInfo>
            <ns2:filer>
                <ns2:filerCredentials>
                    <ns2:cik>0001802897</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
                </ns2:filerCredentials>
            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



        </ns2:filerInfo>
    </ns2:headerData>
    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0001776985</ns2:issuerCik>
            <ns2:issuerName>BIONTECH SE</ns2:issuerName>
            <ns2:secFileNumber>001-39081</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>An der Goldgrube 12</com:street1>
                <com:city>Mainz</com:city>
                <com:stateOrCountry>2M</com:stateOrCountry>
                <com:zipCode>55131</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>49-6131-9084-0</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ATHOS KG</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>10% Stockholder</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>500000</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>61700000</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>237725735</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>09/16/2024</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Ordinary Shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:acquiredDate>01/05/2018</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Private placement</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>BioNTech SE</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>500000</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>01/05/2018</ns2:paymentDate>
            <ns2:natureOfPayment>Cash</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
                    <com:street1>Rosenheimer Platz 6</com:street1>
                    <com:city>Munich</com:city>
                    <com:stateOrCountry>2M</com:stateOrCountry>
                    <com:zipCode>81669</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>09/13/2024</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>170000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>19552584</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
                    <com:street1>Rosenheimer Platz 6</com:street1>
                    <com:city>Munich</com:city>
                    <com:stateOrCountry>2M</com:stateOrCountry>
                    <com:zipCode>81669</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>09/16/2024</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>90000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>11341611</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:remarks>The filing of this Form 144 shall not be construed as an admission that the undersigned is an affiliate of the issuer. All ADS to be sold by AT Impf GmbH. </ns2:remarks>
        <ns2:noticeSignature>
            <ns2:noticeDate>09/16/2024</ns2:noticeDate>
            <ns2:planAdoptionDates/>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of /s/ Thomas Maier /s/ Stephan Sperber</ns2:signature>
        </ns2:noticeSignature>
    </ns2:formData>
</ns2:edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5458}]
144
0001802897
XXXXXXXX
LIVE
0001776985
BIONTECH SE
001-39081
An der Goldgrube 12
Mainz
2M
55131
49-6131-9084-0
ATHOS KG
10% Stockholder
American Depositary Shares representing ordinary shares, no par value per share
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
500000
61700000
237725735
09/16/2024
NASD
Ordinary Shares, no par value per share
01/05/2018
Private placement
BioNTech SE
N
500000
01/05/2018
Cash
N
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
09/13/2024
170000
19552584
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
09/16/2024
90000
11341611
The filing of this Form 144 shall not be construed as an admission that the undersigned is an affiliate of the issuer. All ADS to be sold by AT Impf GmbH.
09/16/2024
Goldman Sachs & Co. LLC on behalf of /s/ Thomas Maier /s/ Stephan Sperber