<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001551778</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001061983</issuerCik>
            <issuerName>CYTOKINETICS, INCORPORATED</issuerName>
            <secFileNumber>000-50633</secFileNumber>
            <issuerAddress>
                <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6506243000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>FADY MALIK</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>12000</noOfUnitsSold>
            <aggregateMarketValue>590280.00</aggregateMarketValue>
            <noOfUnitsOutstanding>118014240</noOfUnitsOutstanding>
            <approxSaleDate>01/07/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/07/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>12000</amountOfSecuritiesAcquired>
            <paymentDate>01/07/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/10/2024</saleDate>
            <amountOfSecuritiesSold>7300</amountOfSecuritiesSold>
            <grossProceeds>369639.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/26/2024</saleDate>
            <amountOfSecuritiesSold>7300</amountOfSecuritiesSold>
            <grossProceeds>366181.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/12/2024</saleDate>
            <amountOfSecuritiesSold>6342</amountOfSecuritiesSold>
            <grossProceeds>370880.16</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/30/2024</saleDate>
            <amountOfSecuritiesSold>7300</amountOfSecuritiesSold>
            <grossProceeds>378930.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FADY MALIK</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/15/2024</saleDate>
            <amountOfSecuritiesSold>7300</amountOfSecuritiesSold>
            <grossProceeds>395554.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>01/07/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/16/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Fady Malik</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 7080}]
144
0001551778
XXXXXXXX
LIVE
0001061983
CYTOKINETICS, INCORPORATED
000-50633
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
6506243000
FADY MALIK
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
12000
590280.00
118014240
01/07/2025
NASDAQ
Common
01/07/2025
Exercise of Stock Options
Issuer
N
12000
01/07/2025
Cash
N
FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
12/10/2024
7300
369639.00
FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
11/26/2024
7300
366181.00
FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
11/12/2024
6342
370880.16
FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
10/30/2024
7300
378930.00
FADY MALIK
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
10/15/2024
7300
395554.00
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
01/07/2025
09/16/2024
/s/ Fady Malik