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          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



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    <issuerInfo>
      <issuerCik>0001521036</issuerCik>
      <issuerName>Lantheus Holdings, Inc.</issuerName>
      <secFileNumber>001-36569</secFileNumber>
      <issuerAddress>
        <com:street1>331 TREBLE COVE ROAD</com:street1>
        <com:city>NORTH BILLERICA</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>01862</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>978 671-8001</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Heino Mary Anne</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Wells Fargo Clearing Services</name>
        <address>
          <com:street1>1 N. Jefferson Ave</com:street1>
          <com:city>St. Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63103</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>11780</noOfUnitsSold>
      <aggregateMarketValue>749419.61</aggregateMarketValue>
      <noOfUnitsOutstanding>68489153</noOfUnitsOutstanding>
      <approxSaleDate>11/13/2023</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/03/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11780</amountOfSecuritiesAcquired>
      <paymentDate>03/03/2022</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>11/13/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>03/09/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>Mary Anne Heino</signature>
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144
0001610676
XXXXXXXX
LIVE
0001521036
Lantheus Holdings, Inc.
001-36569
331 TREBLE COVE ROAD
NORTH BILLERICA
MA
01862
978 671-8001
Heino Mary Anne
Officer
Director
Common
Wells Fargo Clearing Services
1 N. Jefferson Ave
St. Louis
MO
63103
11780
749419.61
68489153
11/13/2023
Nasdaq
Common
03/03/2022
Compensation
Issuer
N
11780
03/03/2022
N/A
Y
11/13/2023
03/09/2023
Mary Anne Heino