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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001023225</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0000939767</issuerCik>
            <issuerName>EXELIXIS, INC.</issuerName>
            <secFileNumber>000-30235</secFileNumber>
            <issuerAddress>
                <ns2:street1>1851 Harbor Bay Parkway</ns2:street1>
                <ns2:city>Alameda</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94502</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 837-7000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JACK L WYSZOMIERSKI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>8287</noOfUnitsSold>
            <aggregateMarketValue>182335.55</aggregateMarketValue>
            <noOfUnitsOutstanding>291292704</noOfUnitsOutstanding>
            <approxSaleDate>06/04/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>06/01/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>8287</amountOfSecuritiesAcquired>
            <paymentDate>06/01/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JACK L WYSZOMIERSKI</name>
                <address>
                    <ns2:street1>1851 Harbor Bay Parkway</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/13/2024</saleDate>
            <amountOfSecuritiesSold>10923</amountOfSecuritiesSold>
            <grossProceeds>233402.66</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/04/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/12/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jack Wyszomierski</signature>
        </noticeSignature>
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144
0001023225
XXXXXXXX
LIVE
0000939767
EXELIXIS, INC.
000-30235
1851 Harbor Bay Parkway
Alameda
CA
94502
(650) 837-7000
JACK L WYSZOMIERSKI
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
8287
182335.55
291292704
06/04/2024
NASDAQ
COMMON
06/01/2024
Restricted Stock
ISSUER
N
8287
06/01/2024
Not Applicable
N
JACK L WYSZOMIERSKI
1851 Harbor Bay Parkway
Alameda
CA
94502
Common
05/13/2024
10923
233402.66
06/04/2024
02/12/2024
/s/ Jack Wyszomierski