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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001702265</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001658247</issuerCik>
            <issuerName>CRINETICS PHARMACEUTICALS, INC.</issuerName>
            <secFileNumber>001-38583</secFileNumber>
            <issuerAddress>
                <ns2:street1>6055 Lusk Boulevard</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92121</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(858) 450-6464</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MARC WILSON</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>25000</noOfUnitsSold>
            <aggregateMarketValue>1277625.00</aggregateMarketValue>
            <noOfUnitsOutstanding>80035610</noOfUnitsOutstanding>
            <approxSaleDate>09/26/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>09/26/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>25000</amountOfSecuritiesAcquired>
            <paymentDate>09/26/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MARC WILSON</name>
                <address>
                    <ns2:street1>6055 Lusk Boulevard</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/25/2024</saleDate>
            <amountOfSecuritiesSold>19056</amountOfSecuritiesSold>
            <grossProceeds>1026701.07</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MARC WILSON</name>
                <address>
                    <ns2:street1>6055 Lusk Boulevard</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/15/2024</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>1375000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MARC WILSON</name>
                <address>
                    <ns2:street1>6055 Lusk Boulevard</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/28/2024</saleDate>
            <amountOfSecuritiesSold>32129</amountOfSecuritiesSold>
            <grossProceeds>1401251.72</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>09/26/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/28/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Marc Wilson</signature>
        </noticeSignature>
    </formData>
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144
0001702265
XXXXXXXX
LIVE
0001658247
CRINETICS PHARMACEUTICALS, INC.
001-38583
6055 Lusk Boulevard
San Diego
CA
92121
(858) 450-6464
MARC WILSON
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
25000
1277625.00
80035610
09/26/2024
NASDAQ
COMMON
09/26/2024
Stock Option Exercise
ISSUER
N
25000
09/26/2024
Cash
N
MARC WILSON
6055 Lusk Boulevard
San Diego
CA
92121
Common
07/25/2024
19056
1026701.07
MARC WILSON
6055 Lusk Boulevard
San Diego
CA
92121
Common
07/15/2024
25000
1375000.00
MARC WILSON
6055 Lusk Boulevard
San Diego
CA
92121
Common
06/28/2024
32129
1401251.72
09/26/2024
03/28/2024
/s/ Marc Wilson