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                    <ccc>XXXXXXXX</ccc>
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            <secFileNumber>001-40445</secFileNumber>
            <issuerAddress>
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                <ns2:city>ALTRINCHAM</ns2:city>
                <ns2:stateOrCountry>X0</ns2:stateOrCountry>
                <ns2:zipCode>WA14 2DT</ns2:zipCode>
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            <issuerContactPhone>44 203 9206789</issuerContactPhone>
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            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>ADR</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>9350</noOfUnitsSold>
            <aggregateMarketValue>67684.65</aggregateMarketValue>
            <noOfUnitsOutstanding>97402945</noOfUnitsOutstanding>
            <approxSaleDate>09/01/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
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            <securitiesClassTitle>ADR</securitiesClassTitle>
            <acquiredDate>09/01/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>9350</amountOfSecuritiesAcquired>
            <paymentDate>09/01/2023</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <address>
                    <ns2:street1>3RD FLOOR, 1 ASHLEY ROAD</ns2:street1>
                    <ns2:city>ALTRINCHAM</ns2:city>
                    <ns2:stateOrCountry>X0</ns2:stateOrCountry>
                    <ns2:zipCode>WA14 2DT</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>ADR</securitiesClassTitle>
            <saleDate>08/01/2023</saleDate>
            <amountOfSecuritiesSold>9800</amountOfSecuritiesSold>
            <grossProceeds>70386.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
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                <address>
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                    <ns2:city>ALTRINCHAM</ns2:city>
                    <ns2:stateOrCountry>X0</ns2:stateOrCountry>
                    <ns2:zipCode>WA14 2DT</ns2:zipCode>
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            </sellerDetails>
            <securitiesClassTitle>ADR</securitiesClassTitle>
            <saleDate>07/03/2023</saleDate>
            <amountOfSecuritiesSold>9350</amountOfSecuritiesSold>
            <grossProceeds>55907.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>09/01/2023</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Antoine Yver</signature>
        </noticeSignature>
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144
0001861878
XXXXXXXX
LIVE
0001847903
CENTESSA PHARMACEUTICALS PLC
001-40445
3RD FLOOR, 1 ASHLEY ROAD
ALTRINCHAM
X0
WA14 2DT
44 203 9206789
ANTOINE JEAN YVER
Officer
ADR
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
9350
67684.65
97402945
09/01/2023
NASDAQ
ADR
09/01/2023
Restricted stock vesting under a registered plan
Issuer
N
9350
09/01/2023
Services Rendered
N
Antoine Yver
3RD FLOOR, 1 ASHLEY ROAD
ALTRINCHAM
X0
WA14 2DT
ADR
08/01/2023
9800
70386.00
Antoine Yver
3RD FLOOR, 1 ASHLEY ROAD
ALTRINCHAM
X0
WA14 2DT
ADR
07/03/2023
9350
55907.00
09/01/2023
/s/ Antoine Yver