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        <submissionType>144</submissionType>
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            <filer>
                <filerCredentials>
                    <cik>0002009280</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001840706</issuerCik>
            <issuerName>SOPHIA GENETICS SA</issuerName>
            <secFileNumber>001-40627</secFileNumber>
            <issuerAddress>
                <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                <ns2:city>Rolle</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41216941060</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MANUELA VALENTE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>3930</noOfUnitsSold>
            <aggregateMarketValue>11947.20</aggregateMarketValue>
            <noOfUnitsOutstanding>66687085</noOfUnitsOutstanding>
            <approxSaleDate>07/03/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>07/02/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3930</amountOfSecuritiesAcquired>
            <paymentDate>07/02/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/23/2025</saleDate>
            <amountOfSecuritiesSold>66</amountOfSecuritiesSold>
            <grossProceeds>198.56</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/20/2025</saleDate>
            <amountOfSecuritiesSold>381</amountOfSecuritiesSold>
            <grossProceeds>1126.96</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/23/2025</saleDate>
            <amountOfSecuritiesSold>65</amountOfSecuritiesSold>
            <grossProceeds>186.78</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/19/2025</saleDate>
            <amountOfSecuritiesSold>381</amountOfSecuritiesSold>
            <grossProceeds>1094.80</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/23/2025</saleDate>
            <amountOfSecuritiesSold>66</amountOfSecuritiesSold>
            <grossProceeds>201.29</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/21/2025</saleDate>
            <amountOfSecuritiesSold>381</amountOfSecuritiesSold>
            <grossProceeds>1038.68</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/08/2025</saleDate>
            <amountOfSecuritiesSold>2041</amountOfSecuritiesSold>
            <grossProceeds>5574.58</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/07/2025</saleDate>
            <amountOfSecuritiesSold>1681</amountOfSecuritiesSold>
            <grossProceeds>4492.98</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MANUELA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/04/2025</saleDate>
            <amountOfSecuritiesSold>1518</amountOfSecuritiesSold>
            <grossProceeds>4176.93</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were or will be acquired upon the vesting of restricted stock units during the period of 07/02/2025 through 09/18/2025.

</remarks>
        <noticeSignature>
            <noticeDate>07/03/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/09/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Manuela Valente</signature>
        </noticeSignature>
    </formData>
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144
0002009280
XXXXXXXX
LIVE
0001840706
SOPHIA GENETICS SA
001-40627
La Piece 12 ch-1180
Rolle
V8
00000
41216941060
MANUELA VALENTE
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
3930
11947.20
66687085
07/03/2025
NASDAQ
Common
07/02/2025
Restricted Stock Units
Issuer
N
3930
07/02/2025
N/A
N
10b5-1 Sales for MANUELA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
06/23/2025
66
198.56
10b5-1 Sales for MANUELA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
06/20/2025
381
1126.96
10b5-1 Sales for MANUELA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
05/23/2025
65
186.78
10b5-1 Sales for MANUELA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
05/19/2025
381
1094.80
10b5-1 Sales for MANUELA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/23/2025
66
201.29
10b5-1 Sales for MANUELA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/21/2025
381
1038.68
10b5-1 Sales for MANUELA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/08/2025
2041
5574.58
10b5-1 Sales for MANUELA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/07/2025
1681
4492.98
10b5-1 Sales for MANUELA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/04/2025
1518
4176.93
The securities to be sold were or will be acquired upon the vesting of restricted stock units during the period of 07/02/2025 through 09/18/2025.
07/03/2025
09/09/2024
/s/ Manuela Valente