<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
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    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001665419</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001110803</issuerCik>
      <issuerName>ILLUMINA, INC.</issuerName>
      <secFileNumber>001-35406</secFileNumber>
      <issuerAddress>
        <com:street1>5200 ILLUMINA WAY</com:street1>
        <com:city>SAN DIEGO</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92122</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>8582024500</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ARNOLD FRANCES</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>THE CHARLES SCHWAB CORPORATION</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>120</noOfUnitsSold>
      <aggregateMarketValue>11217.60</aggregateMarketValue>
      <noOfUnitsOutstanding>158400000</noOfUnitsOutstanding>
      <approxSaleDate>02/27/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>11/10/2015</acquiredDate>
      <natureOfAcquisitionTransaction>VARIOUS VIA FOLLOWING DATE RANGE: 11/10/15 TO 12/30/20</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>120</amountOfSecuritiesAcquired>
      <paymentDate>11/10/2015</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>FULL ACCOUNT TITLES PER PLAN: FRANCES H ARNOLD INH IRA &amp; FRANCES H ARNOLD TTEE FRANCES H ARNOLD LIVING TRUST</remarks>
    <noticeSignature>
      <noticeDate>02/27/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>11/06/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>FRANCES H. ARNOLD</signature>
    </noticeSignature>
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144
0001665419
XXXXXXXX
LIVE
0001110803
ILLUMINA, INC.
001-35406
5200 ILLUMINA WAY
SAN DIEGO
CA
92122
8582024500
ARNOLD FRANCES
Director
COMMON
THE CHARLES SCHWAB CORPORATION
3000 Schwab Way
Westlake
TX
76262
120
11217.60
158400000
02/27/2025
NASDAQ
COMMON
11/10/2015
VARIOUS VIA FOLLOWING DATE RANGE: 11/10/15 TO 12/30/20
ISSUER
N
120
11/10/2015
NA
Y
FULL ACCOUNT TITLES PER PLAN: FRANCES H ARNOLD INH IRA & FRANCES H ARNOLD TTEE FRANCES H ARNOLD LIVING TRUST
02/27/2025
11/06/2024
FRANCES H. ARNOLD