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                <filerCredentials>
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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001711279</issuerCik>
            <issuerName>KRYSTAL BIOTECH INC</issuerName>
            <secFileNumber>001-38210</secFileNumber>
            <issuerAddress>
                <ns2:street1>2100 Wharton Street, Suite 701 </ns2:street1>
                <ns2:city>Pittsburgh</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>15203</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>4125865830</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Suma Krishnan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>25000</noOfUnitsSold>
            <aggregateMarketValue>2159500.00</aggregateMarketValue>
            <noOfUnitsOutstanding>25763743</noOfUnitsOutstanding>
            <approxSaleDate>04/17/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/31/2017</acquiredDate>
            <natureOfAcquisitionTransaction>Founders Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>25000</amountOfSecuritiesAcquired>
            <paymentDate>03/31/2017</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for SUMA KRISHNAN</name>
                <address>
                    <ns2:street1>2100 Wharton Street, Suite 701 </ns2:street1>
                    <ns2:city>Pittsburgh</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>15203</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/18/2023</saleDate>
            <amountOfSecuritiesSold>2852</amountOfSecuritiesSold>
            <grossProceeds>230955.25</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/17/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/13/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Suma Krishnan</signature>
        </noticeSignature>
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144
0001298711
XXXXXXXX
LIVE
0001711279
KRYSTAL BIOTECH INC
001-38210
2100 Wharton Street, Suite 701
Pittsburgh
PA
15203
4125865830
Suma Krishnan
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
25000
2159500.00
25763743
04/17/2023
NASDAQ
Common
03/31/2017
Founders Shares
Issuer
N
25000
03/31/2017
N/A
N
10b5-1 Sales Plan for SUMA KRISHNAN
2100 Wharton Street, Suite 701
Pittsburgh
PA
15203
Common
01/18/2023
2852
230955.25
04/17/2023
05/13/2022
/s/ Suma Krishnan