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    <ns2:headerData>
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            <ns2:filer>
                <ns2:filerCredentials>
                    <ns2:cik>0001802897</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
                </ns2:filerCredentials>
            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



        </ns2:filerInfo>
    </ns2:headerData>
    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0001776985</ns2:issuerCik>
            <ns2:issuerName>BIONTECH SE</ns2:issuerName>
            <ns2:secFileNumber>001-39081</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>An der Goldgrube 12</com:street1>
                <com:city>Mainz</com:city>
                <com:stateOrCountry>2M</com:stateOrCountry>
                <com:zipCode>55131</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>49-6131-9084-0</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ATHOS KG</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>10% Stockholder</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>100000</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>9279000</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>237715500</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>02/28/2024</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Ordinary Shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:acquiredDate>01/05/2018</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Private placement</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>BioNTech SE</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>100000</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>01/05/2018</ns2:paymentDate>
            <ns2:natureOfPayment>Cash</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
                    <com:street1>Rosenheimer Platz 6</com:street1>
                    <com:city>Munich</com:city>
                    <com:stateOrCountry>2M</com:stateOrCountry>
                    <com:zipCode>81669</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
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        <ns2:securitiesSoldInPast3Months>
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            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>12/15/2023</ns2:saleDate>
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        <ns2:securitiesSoldInPast3Months>
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            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
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        <ns2:securitiesSoldInPast3Months>
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            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>12/19/2023</ns2:saleDate>
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        <ns2:securitiesSoldInPast3Months>
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                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
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                    <com:stateOrCountry>2M</com:stateOrCountry>
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                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>12/20/2023</ns2:saleDate>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
                    <com:street1>Rosenheimer Platz 6</com:street1>
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                    <com:stateOrCountry>2M</com:stateOrCountry>
                    <com:zipCode>81669</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>12/21/2023</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>50000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>5168910</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
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                    <com:stateOrCountry>2M</com:stateOrCountry>
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            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>12/22/2023</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>60000</ns2:amountOfSecuritiesSold>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
                    <com:street1>Rosenheimer Platz 6</com:street1>
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                    <com:stateOrCountry>2M</com:stateOrCountry>
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            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>12/26/2023</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>54000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>5659291.8</ns2:grossProceeds>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
                    <com:street1>Rosenheimer Platz 6</com:street1>
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                    <com:stateOrCountry>2M</com:stateOrCountry>
                    <com:zipCode>81669</com:zipCode>
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            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>12/27/2023</ns2:saleDate>
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        <ns2:securitiesSoldInPast3Months>
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            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
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            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
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            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
                    <com:street1>Rosenheimer Platz 6</com:street1>
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                    <com:stateOrCountry>2M</com:stateOrCountry>
                    <com:zipCode>81669</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>01/03/2024</ns2:saleDate>
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            <ns2:grossProceeds>3423921.73</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
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                    <com:stateOrCountry>2M</com:stateOrCountry>
                    <com:zipCode>81669</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>01/04/2024</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>25000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>2690510</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
                    <com:street1>Rosenheimer Platz 6</com:street1>
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                    <com:stateOrCountry>2M</com:stateOrCountry>
                    <com:zipCode>81669</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>01/05/2024</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>150000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>16535685</ns2:grossProceeds>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
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            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
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            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
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                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
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                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>01/12/2024</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>3900</ns2:amountOfSecuritiesSold>
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        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
                    <com:street1>Rosenheimer Platz 6</com:street1>
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                    <com:stateOrCountry>2M</com:stateOrCountry>
                    <com:zipCode>81669</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>01/23/2024</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>10000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>1000626</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>AT Impf GmbH</ns2:name>
                <ns2:address>
                    <com:street1>Rosenheimer Platz 6</com:street1>
                    <com:city>Munich</com:city>
                    <com:stateOrCountry>2M</com:stateOrCountry>
                    <com:zipCode>81669</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</ns2:securitiesClassTitle>
            <ns2:saleDate>01/24/2024</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1647</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>165192.12</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:remarks>The filing of this Form 144 shall not be construed as an admission that the undersigned is an affiliate of the issuer. All ADS to be sold by AT Impf GmbH. </ns2:remarks>
        <ns2:noticeSignature>
            <ns2:noticeDate>02/28/2024</ns2:noticeDate>
            <ns2:planAdoptionDates/>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of /s/ Thomas Maier /s/ Stephan Sperber</ns2:signature>
        </ns2:noticeSignature>
    </ns2:formData>
</ns2:edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 21134}]
144
0001802897
XXXXXXXX
LIVE
0001776985
BIONTECH SE
001-39081
An der Goldgrube 12
Mainz
2M
55131
49-6131-9084-0
ATHOS KG
10% Stockholder
American Depositary Shares representing ordinary shares, no par value per share
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
100000
9279000
237715500
02/28/2024
NASD
Ordinary Shares, no par value per share
01/05/2018
Private placement
BioNTech SE
N
100000
01/05/2018
Cash
N
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/14/2023
42000
4360410.6
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/15/2023
60000
6138888
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/18/2023
52036
5340496.31
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/19/2023
60000
6354228
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/20/2023
50852
5306040.07
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/21/2023
50000
5168910
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/22/2023
60000
6330108
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/26/2023
54000
5659291.8
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/27/2023
60000
6421350
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/28/2023
50500
5350919.4
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
12/29/2023
50000
5262440
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
01/02/2024
85000
9473233
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
01/03/2024
31089
3423921.73
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
01/04/2024
25000
2690510
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
01/05/2024
150000
16535685
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
01/08/2024
150000
16595295
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
01/10/2024
20000
2094096
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
01/11/2024
12494
1302990.51
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
01/12/2024
3900
407675.97
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
01/23/2024
10000
1000626
AT Impf GmbH
Rosenheimer Platz 6
Munich
2M
81669
American Depositary Shares representing ordinary shares, no par value per share
01/24/2024
1647
165192.12
The filing of this Form 144 shall not be construed as an admission that the undersigned is an affiliate of the issuer. All ADS to be sold by AT Impf GmbH.
02/28/2024
Goldman Sachs & Co. LLC on behalf of /s/ Thomas Maier /s/ Stephan Sperber