<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0002009280</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001840706</issuerCik>
            <issuerName>SOPHIA GENETICS SA</issuerName>
            <secFileNumber>001-40627</secFileNumber>
            <issuerAddress>
                <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                <ns2:city>Rolle</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41216941060</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MANUELA VALENTE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>3423</noOfUnitsSold>
            <aggregateMarketValue>11330.13</aggregateMarketValue>
            <noOfUnitsOutstanding>65230559</noOfUnitsOutstanding>
            <approxSaleDate>12/24/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/18/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3423</amountOfSecuritiesAcquired>
            <paymentDate>12/18/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MANUELA DA SILVA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/19/2024</saleDate>
            <amountOfSecuritiesSold>495</amountOfSecuritiesSold>
            <grossProceeds>1633.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MANUELA DA SILVA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/22/2024</saleDate>
            <amountOfSecuritiesSold>495</amountOfSecuritiesSold>
            <grossProceeds>1633.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MANUELA DA SILVA VALENTE</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/04/2024</saleDate>
            <amountOfSecuritiesSold>1860</amountOfSecuritiesSold>
            <grossProceeds>6026.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 12/18/2024 through 03/18/2025.
Sales that were executed on December 24, 2024 are being reported on this Form 144 filed on December 26, 2024 given the EDGAR system was not accepting filings on December 24, 2024, which is being treated as a federal holiday for filing purposes.</remarks>
        <noticeSignature>
            <noticeDate>12/24/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/09/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Manuela Valente</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5790}]
144
0002009280
XXXXXXXX
LIVE
0001840706
SOPHIA GENETICS SA
001-40627
La Piece 12 ch-1180
Rolle
V8
00000
41216941060
MANUELA VALENTE
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
3423
11330.13
65230559
12/24/2024
NASDAQ
Common
12/18/2024
Restricted Stock Units
Issuer
N
3423
12/18/2024
N/A
N
MANUELA DA SILVA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
11/19/2024
495
1633.50
MANUELA DA SILVA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
10/22/2024
495
1633.50
MANUELA DA SILVA VALENTE
La Piece 12 ch-1180
Rolle
V8
00000
Common
10/04/2024
1860
6026.40
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 12/18/2024 through 03/18/2025.
Sales that were executed on December 24, 2024 are being reported on this Form 144 filed on December 26, 2024 given the EDGAR system was not accepting filings on December 24, 2024, which is being treated as a federal holiday for filing purposes.
12/24/2024
09/09/2024
/s/ Manuela Valente