<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001722024</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001567514</issuerCik>
            <issuerName>INTRA-CELLULAR THERAPIES INC.</issuerName>
            <secFileNumber>001-36274</secFileNumber>
            <issuerAddress>
                <ns2:street1>430 EAST 29TH STREET</ns2:street1>
                <ns2:city>NEW YORK</ns2:city>
                <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                <ns2:zipCode>10016</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>212-923-3344</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ALEXANDRIA VENTURE INVESTMENTS LLC</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>55000</noOfUnitsSold>
            <aggregateMarketValue>3416567.00</aggregateMarketValue>
            <noOfUnitsOutstanding>96238126</noOfUnitsOutstanding>
            <approxSaleDate>12/01/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/10/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Private Acquisition from Issuer/Affiliate</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>55000</amountOfSecuritiesAcquired>
            <paymentDate>02/10/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Alexandria Venture Investments LLC</name>
                <address>
                    <ns2:street1>430 EAST 29TH STREET</ns2:street1>
                    <ns2:city>NEW YORK</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10016</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/06/2023</saleDate>
            <amountOfSecuritiesSold>23000</amountOfSecuritiesSold>
            <grossProceeds>1280382.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ALEXANDRIA VENTURE INVESTMENTS LLC</name>
                <address>
                    <ns2:street1>430 EAST 29TH STREET</ns2:street1>
                    <ns2:city>NEW YORK</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10016</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/13/2023</saleDate>
            <amountOfSecuritiesSold>55500</amountOfSecuritiesSold>
            <grossProceeds>3223287.38</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>12/01/2023</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Marc Binda</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4682}]
144
0001722024
XXXXXXXX
LIVE
0001567514
INTRA-CELLULAR THERAPIES INC.
001-36274
430 EAST 29TH STREET
NEW YORK
NY
10016
212-923-3344
ALEXANDRIA VENTURE INVESTMENTS LLC
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
55000
3416567.00
96238126
12/01/2023
NASD
Common
02/10/2021
Private Acquisition from Issuer/Affiliate
Issuer
N
55000
02/10/2021
Cash
N
Alexandria Venture Investments LLC
430 EAST 29TH STREET
NEW YORK
NY
10016
Common
11/06/2023
23000
1280382.40
ALEXANDRIA VENTURE INVESTMENTS LLC
430 EAST 29TH STREET
NEW YORK
NY
10016
Common
09/13/2023
55500
3223287.38
12/01/2023
/s/ Marc Binda