<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001543970</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000763901</issuerCik>
      <issuerName>POPULAR, INC.</issuerName>
      <secFileNumber>001-34084</secFileNumber>
      <issuerAddress>
        <com:street1>209 MUNOZ RIVERA AVE</com:street1>
        <com:street2>POPULAR CENTER BUILDING</com:street2>
        <com:city>HATO REY</com:city>
        <com:stateOrCountry>PR</com:stateOrCountry>
        <com:zipCode>00918</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>7877659800</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Garcia Jorge J.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>affiliate</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1355</noOfUnitsSold>
      <aggregateMarketValue>87085.00</aggregateMarketValue>
      <noOfUnitsOutstanding>72127733</noOfUnitsOutstanding>
      <approxSaleDate>08/22/2023</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/23/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Popular, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1355</amountOfSecuritiesAcquired>
      <paymentDate>02/23/2023</paymentDate>
      <natureOfPayment>Restricted Stock Award</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>acquisition dates: award date 2/14/2019-2/22/2022 vesting date 2/23/2023</remarks>
    <noticeSignature>
      <noticeDate>08/22/2023</noticeDate>
      <signature>Jorge J. Garcia</signature>
    </noticeSignature>
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144
0001543970
XXXXXXXX
LIVE
0000763901
POPULAR, INC.
001-34084
209 MUNOZ RIVERA AVE
POPULAR CENTER BUILDING
HATO REY
PR
00918
7877659800
Garcia Jorge J.
affiliate
Common
Charles Schwab & Co., Inc.
3000 Schwab Way
Westlake
TX
76262
1355
87085.00
72127733
08/22/2023
Nasdaq
Common
02/23/2023
Restricted Stock Award
Popular, Inc.
N
1355
02/23/2023
Restricted Stock Award
Y
acquisition dates: award date 2/14/2019-2/22/2022 vesting date 2/23/2023
08/22/2023
Jorge J. Garcia