<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001254781</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001107843</issuerCik>
            <issuerName>QUALYS, INC.</issuerName>
            <secFileNumber>001-35662</secFileNumber>
            <issuerAddress>
                <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                <ns2:city> Foster City</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94404</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6508016100</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BRUCE POSEY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>3999</noOfUnitsSold>
            <aggregateMarketValue>588332.88</aggregateMarketValue>
            <noOfUnitsOutstanding>36939262</noOfUnitsOutstanding>
            <approxSaleDate>05/20/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/20/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3000</amountOfSecuritiesAcquired>
            <paymentDate>05/20/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/01/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>999</amountOfSecuritiesAcquired>
            <paymentDate>05/01/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for BRUCE K. POSEY</name>
                <address>
                    <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                    <ns2:city> Foster City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94404</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/22/2024</saleDate>
            <amountOfSecuritiesSold>1443</amountOfSecuritiesSold>
            <grossProceeds>241456.75</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for BRUCE K. POSEY</name>
                <address>
                    <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                    <ns2:city> Foster City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94404</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/20/2024</saleDate>
            <amountOfSecuritiesSold>1430</amountOfSecuritiesSold>
            <grossProceeds>235818.37</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.</remarks>
        <noticeSignature>
            <noticeDate>05/20/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/28/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Bruce Posey</signature>
        </noticeSignature>
    </formData>
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144
0001254781
XXXXXXXX
LIVE
0001107843
QUALYS, INC.
001-35662
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
6508016100
BRUCE POSEY
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
3999
588332.88
36939262
05/20/2024
NASDAQ
Common
05/20/2024
Exercise of Stock Options
Issuer
N
3000
05/20/2024
Cash
Common
05/01/2024
Restricted Stock Units
Issuer
N
999
05/01/2024
N/A
N
10b5-1 Sales Plan for BRUCE K. POSEY
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
Common
04/22/2024
1443
241456.75
10b5-1 Sales Plan for BRUCE K. POSEY
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
Common
03/20/2024
1430
235818.37
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
05/20/2024
08/28/2023
/s/ Bruce Posey