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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001695955</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001665918</issuerCik>
      <issuerName>US Foods Holding Corp.</issuerName>
      <secFileNumber>001-37786</secFileNumber>
      <issuerAddress>
        <com:street1>9399 W. HIGGINS RD.</com:street1>
        <com:street2>SUITE 100</com:street2>
        <com:city>ROSEMONT</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60018</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>8477208000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Iacobucci Andrew E.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>189453</noOfUnitsSold>
      <aggregateMarketValue>7448448.47</aggregateMarketValue>
      <noOfUnitsOutstanding>232652077</noOfUnitsOutstanding>
      <approxSaleDate>05/24/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/24/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted - 06/03/2017</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>25101</amountOfSecuritiesAcquired>
      <paymentDate>05/24/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/24/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted - 03/26/2018</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>21863</amountOfSecuritiesAcquired>
      <paymentDate>05/24/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/24/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted - 03/25/2019</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>34651</amountOfSecuritiesAcquired>
      <paymentDate>05/24/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/24/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted - 03/23/2020</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>85252</amountOfSecuritiesAcquired>
      <paymentDate>05/24/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/24/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted - 03/29/2021</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>22354</amountOfSecuritiesAcquired>
      <paymentDate>05/24/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>11/29/2019</acquiredDate>
      <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>89</amountOfSecuritiesAcquired>
      <paymentDate>11/29/2019</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/28/2020</acquiredDate>
      <natureOfAcquisitionTransaction>ESPP Purchase</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>143</amountOfSecuritiesAcquired>
      <paymentDate>02/28/2020</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Andrew Iacobucci</name>
        <address>
          <com:street1>9399 W. Higgins Road</com:street1>
          <com:street2>Suite 100</com:street2>
          <com:city>Rosemont</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60018</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/24/2023</saleDate>
      <amountOfSecuritiesSold>21954</amountOfSecuritiesSold>
      <grossProceeds>761145.18</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Andrew Iacobucci</name>
        <address>
          <com:street1>9399 W. Higgins Road</com:street1>
          <com:street2>Suite 100</com:street2>
          <com:city>Rosemont</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60018</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/29/2023</saleDate>
      <amountOfSecuritiesSold>2728</amountOfSecuritiesSold>
      <grossProceeds>99844.80</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Andrew Iacobucci</name>
        <address>
          <com:street1>9399 W. Higgins Road</com:street1>
          <com:street2>Suite 100</com:street2>
          <com:city>Rosemont</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60018</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/30/2023</saleDate>
      <amountOfSecuritiesSold>2278</amountOfSecuritiesSold>
      <grossProceeds>83238.12</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/24/2023</noticeDate>
      <signature>/s/ Jennifer Ruchti, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Andrew E. Iacobucci</signature>
    </noticeSignature>
  </formData>
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144
0001695955
XXXXXXXX
LIVE
0001665918
US Foods Holding Corp.
001-37786
9399 W. HIGGINS RD.
SUITE 100
ROSEMONT
IL
60018
8477208000
Iacobucci Andrew E.
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
189453
7448448.47
232652077
05/24/2023
NYSE
Common
05/24/2023
Option Granted - 06/03/2017
Issuer
N
25101
05/24/2023
Cash
Common
05/24/2023
Option Granted - 03/26/2018
Issuer
N
21863
05/24/2023
Cash
Common
05/24/2023
Option Granted - 03/25/2019
Issuer
N
34651
05/24/2023
Cash
Common
05/24/2023
Option Granted - 03/23/2020
Issuer
N
85252
05/24/2023
Cash
Common
05/24/2023
Option Granted - 03/29/2021
Issuer
N
22354
05/24/2023
Cash
Common
11/29/2019
ESPP Purchase
Issuer
N
89
11/29/2019
Cash
Common
02/28/2020
ESPP Purchase
Issuer
N
143
02/28/2020
Cash
N
Andrew Iacobucci
9399 W. Higgins Road
Suite 100
Rosemont
IL
60018
Common
03/24/2023
21954
761145.18
Andrew Iacobucci
9399 W. Higgins Road
Suite 100
Rosemont
IL
60018
Common
03/29/2023
2728
99844.80
Andrew Iacobucci
9399 W. Higgins Road
Suite 100
Rosemont
IL
60018
Common
03/30/2023
2278
83238.12
05/24/2023
/s/ Jennifer Ruchti, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Andrew E. Iacobucci