<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001614265</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001124140</issuerCik>
      <issuerName>EXACT SCIENCES CORP</issuerName>
      <secFileNumber>001-35092</secFileNumber>
      <issuerAddress>
        <com:street1>5505 ENDEAVOR LANE</com:street1>
        <com:city>MADISON</com:city>
        <com:stateOrCountry>WI</com:stateOrCountry>
        <com:zipCode>53719</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>608-284-5700</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Doyle James Edward</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2000</noOfUnitsSold>
      <aggregateMarketValue>194840.00</aggregateMarketValue>
      <noOfUnitsOutstanding>180388167</noOfUnitsOutstanding>
      <approxSaleDate>07/27/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/17/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2000</amountOfSecuritiesAcquired>
      <paymentDate>03/17/2022</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>James Doyle</name>
        <address>
          <com:street1>5505 Endeavor Lane</com:street1>
          <com:city>Madison</com:city>
          <com:stateOrCountry>WI</com:stateOrCountry>
          <com:zipCode>53719</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/26/2023</saleDate>
      <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
      <grossProceeds>161240.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>James Doyle</name>
        <address>
          <com:street1>5505 Endeavor Lane</com:street1>
          <com:city>Madison</com:city>
          <com:stateOrCountry>WI</com:stateOrCountry>
          <com:zipCode>53719</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/09/2023</saleDate>
      <amountOfSecuritiesSold>1402</amountOfSecuritiesSold>
      <grossProceeds>126895.02</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>07/27/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>02/24/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Jared Cook, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for James Doyle</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4085}]
144
0001614265
XXXXXXXX
LIVE
0001124140
EXACT SCIENCES CORP
001-35092
5505 ENDEAVOR LANE
MADISON
WI
53719
608-284-5700
Doyle James Edward
Director
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
2000
194840.00
180388167
07/27/2023
NASDAQ
Common
03/17/2022
Stock Option Exercise
Issuer
N
2000
03/17/2022
Cash
N
James Doyle
5505 Endeavor Lane
Madison
WI
53719
Common
05/26/2023
2000
161240.00
James Doyle
5505 Endeavor Lane
Madison
WI
53719
Common
06/09/2023
1402
126895.02
07/27/2023
02/24/2023
/s/ Jared Cook, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for James Doyle