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    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001813684</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000927653</issuerCik>
      <issuerName>MCKESSON CORP</issuerName>
      <secFileNumber>001-13252</secFileNumber>
      <issuerAddress>
        <com:street1>6555 STATE HIGHWAY 161</com:street1>
        <com:city>IRVING</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>75039</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>972-446-4800</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Rodgers Thomas L</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>645</noOfUnitsSold>
      <aggregateMarketValue>255226.50</aggregateMarketValue>
      <noOfUnitsOutstanding>135602262</noOfUnitsOutstanding>
      <approxSaleDate>06/06/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/05/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>645</amountOfSecuritiesAcquired>
      <paymentDate>06/05/2023</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>THOMAS RODGERS</name>
        <address>
          <com:street1>6555 State Hwy 161</com:street1>
          <com:city>Irving</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75039</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/26/2023</saleDate>
      <amountOfSecuritiesSold>356</amountOfSecuritiesSold>
      <grossProceeds>140399.28</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>THOMAS RODGERS</name>
        <address>
          <com:street1>6555 State Hwy 161</com:street1>
          <com:city>Irving</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75039</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/30/2023</saleDate>
      <amountOfSecuritiesSold>536</amountOfSecuritiesSold>
      <grossProceeds>205765.04</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>THOMAS RODGERS</name>
        <address>
          <com:street1>6555 State Hwy 161</com:street1>
          <com:city>Irving</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75039</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/31/2023</saleDate>
      <amountOfSecuritiesSold>6044</amountOfSecuritiesSold>
      <grossProceeds>2256104.32</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/06/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/08/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Thomas L. Rodgers</signature>
    </noticeSignature>
  </formData>
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144
0001813684
XXXXXXXX
LIVE
0000927653
MCKESSON CORP
001-13252
6555 STATE HIGHWAY 161
IRVING
TX
75039
972-446-4800
Rodgers Thomas L
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
645
255226.50
135602262
06/06/2023
NYSE
Common
06/05/2023
Restricted Stock Vesting
Issuer
N
645
06/05/2023
Compensation
N
THOMAS RODGERS
6555 State Hwy 161
Irving
TX
75039
Common
05/26/2023
356
140399.28
THOMAS RODGERS
6555 State Hwy 161
Irving
TX
75039
Common
05/30/2023
536
205765.04
THOMAS RODGERS
6555 State Hwy 161
Irving
TX
75039
Common
05/31/2023
6044
2256104.32
06/06/2023
08/08/2022
/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Thomas L. Rodgers