<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001400973</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001178879</issuerCik>
            <issuerName>AMICUS THERAPEUTICS INC</issuerName>
            <secFileNumber>001-33497</secFileNumber>
            <issuerAddress>
                <ns2:street1>3675 Market Street</ns2:street1>
                <ns2:city>Philadelphia</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19104</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>2159217600</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JOHN F. CROWLEY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>6043</noOfUnitsSold>
            <aggregateMarketValue>65083.11</aggregateMarketValue>
            <noOfUnitsOutstanding>293245738</noOfUnitsOutstanding>
            <approxSaleDate>11/15/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/31/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6043</amountOfSecuritiesAcquired>
            <paymentDate>12/31/2022</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for JOHN CROWLEY</name>
                <address>
                    <ns2:street1>3675 Market Street</ns2:street1>
                    <ns2:city>Philadelphia</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/01/2023</saleDate>
            <amountOfSecuritiesSold>6044</amountOfSecuritiesSold>
            <grossProceeds>66327.46</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for JOHN CROWLEY</name>
                <address>
                    <ns2:street1>3675 Market Street</ns2:street1>
                    <ns2:city>Philadelphia</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/16/2023</saleDate>
            <amountOfSecuritiesSold>6044</amountOfSecuritiesSold>
            <grossProceeds>63449.31</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for JOHN CROWLEY</name>
                <address>
                    <ns2:street1>3675 Market Street</ns2:street1>
                    <ns2:city>Philadelphia</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/02/2023</saleDate>
            <amountOfSecuritiesSold>6044</amountOfSecuritiesSold>
            <grossProceeds>67967.20</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for JOHN CROWLEY</name>
                <address>
                    <ns2:street1>3675 Market Street</ns2:street1>
                    <ns2:city>Philadelphia</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/15/2023</saleDate>
            <amountOfSecuritiesSold>6044</amountOfSecuritiesSold>
            <grossProceeds>78963.65</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for JOHN CROWLEY</name>
                <address>
                    <ns2:street1>3675 Market Street</ns2:street1>
                    <ns2:city>Philadelphia</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/01/2023</saleDate>
            <amountOfSecuritiesSold>6044</amountOfSecuritiesSold>
            <grossProceeds>78447.49</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>11/15/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/07/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ John F. Crowley</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6945}]
144
0001400973
XXXXXXXX
LIVE
0001178879
AMICUS THERAPEUTICS INC
001-33497
3675 Market Street
Philadelphia
PA
19104
2159217600
JOHN F. CROWLEY
Director
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
6043
65083.11
293245738
11/15/2023
NASDAQ
Common
12/31/2022
Performance Stock Units
Issuer
N
6043
12/31/2022
N/A
N
10b5-1 Sales Plan for JOHN CROWLEY
3675 Market Street
Philadelphia
PA
19104
Common
11/01/2023
6044
66327.46
10b5-1 Sales Plan for JOHN CROWLEY
3675 Market Street
Philadelphia
PA
19104
Common
10/16/2023
6044
63449.31
10b5-1 Sales Plan for JOHN CROWLEY
3675 Market Street
Philadelphia
PA
19104
Common
10/02/2023
6044
67967.20
10b5-1 Sales Plan for JOHN CROWLEY
3675 Market Street
Philadelphia
PA
19104
Common
09/15/2023
6044
78963.65
10b5-1 Sales Plan for JOHN CROWLEY
3675 Market Street
Philadelphia
PA
19104
Common
09/01/2023
6044
78447.49
11/15/2023
09/07/2022
/s/ John F. Crowley