<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001755922</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001571949</issuerCik>
            <issuerName>INTERCONTINENTAL EXCHANGE, INC.</issuerName>
            <secFileNumber>001-36198</secFileNumber>
            <issuerAddress>
                <ns2:street1>5660 New Northside Drive</ns2:street1>
                <ns2:city>Atlanta</ns2:city>
                <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                <ns2:zipCode>30328</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>7708574700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold> ANDREW SURDYKOWSKI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>7698</noOfUnitsSold>
            <aggregateMarketValue>1378942.74</aggregateMarketValue>
            <noOfUnitsOutstanding>573626271</noOfUnitsOutstanding>
            <approxSaleDate>06/05/2025</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/05/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3540</amountOfSecuritiesAcquired>
            <paymentDate>06/05/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/04/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>4158</amountOfSecuritiesAcquired>
            <paymentDate>02/04/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
The securities to be sold were acquired upon the vesting of performance stock units during the period of 02/04/2025 through 02/15/2025.
</remarks>
        <noticeSignature>
            <noticeDate>06/05/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/20/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Andrew Surdykowski</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4270}]
144
0001755922
XXXXXXXX
LIVE
0001571949
INTERCONTINENTAL EXCHANGE, INC.
001-36198
5660 New Northside Drive
Atlanta
GA
30328
7708574700
ANDREW SURDYKOWSKI
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
7698
1378942.74
573626271
06/05/2025
NYSE
Common
06/05/2025
Exercise of Stock Options
Issuer
N
3540
06/05/2025
Cash
Common
02/04/2025
Performance Stock Units
Issuer
N
4158
02/04/2025
N/A
Y
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
The securities to be sold were acquired upon the vesting of performance stock units during the period of 02/04/2025 through 02/15/2025.
06/05/2025
11/20/2024
/s/ Andrew Surdykowski