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            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



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            <ns2:issuerName>Vertex Pharmaceuticals Incorporated</ns2:issuerName>
            <ns2:secFileNumber>000-19319</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>50 Northern Avenue</com:street1>
                <com:city>Boston</com:city>
                <com:stateOrCountry>MA</com:stateOrCountry>
                <com:zipCode>02210</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>1-617-341-6100</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SR 2019 Benefit Trust</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Director</ns2:relationshipToIssuer>
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        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>170</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>76020.6</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>256797187</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>05/21/2025</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
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            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>11/08/2013</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from public market</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Public market</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>20</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>11/08/2013</ns2:paymentDate>
            <ns2:natureOfPayment>Cash</ns2:natureOfPayment>
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        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>05/06/2014</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from public market</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Public market</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>75</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>05/06/2014</ns2:paymentDate>
            <ns2:natureOfPayment>Cash</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>05/14/2014</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from public market</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Public market</ns2:nameOfPersonfromWhomAcquired>
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            <ns2:paymentDate>05/14/2014</ns2:paymentDate>
            <ns2:natureOfPayment>Cash</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:noticeSignature>
            <ns2:noticeDate>05/21/2025</ns2:noticeDate>
            <ns2:planAdoptionDates/>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of SR 2019 Benefit Trust</ns2:signature>
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144
0002068574
XXXXXXXX
LIVE
0000875320
Vertex Pharmaceuticals Incorporated
000-19319
50 Northern Avenue
Boston
MA
02210
1-617-341-6100
SR 2019 Benefit Trust
Director
Common
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
170
76020.6
256797187
05/21/2025
NASD
Common
11/08/2013
Acquired from public market
Public market
N
20
11/08/2013
Cash
Common
05/06/2014
Acquired from public market
Public market
N
75
05/06/2014
Cash
Common
05/14/2014
Acquired from public market
Public market
N
75
05/14/2014
Cash
Y
05/21/2025
Goldman Sachs & Co. LLC on behalf of SR 2019 Benefit Trust