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    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001657709</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001631574</issuerCik>
            <issuerName>WAVE LIFE SCIENCES LTD.</issuerName>
            <secFileNumber>001-37627</secFileNumber>
            <issuerAddress>
                <ns2:street1>7 Straits View #12-00</ns2:street1>
                <ns2:street2>Marina One East Tower</ns2:street2>
                <ns2:city>Singapore</ns2:city>
                <ns2:stateOrCountry>U0</ns2:stateOrCountry>
                <ns2:zipCode>018936</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>65 6236 3388</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CHRISTOPHER FRANCIS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>36000</noOfUnitsSold>
            <aggregateMarketValue>576000.00</aggregateMarketValue>
            <noOfUnitsOutstanding>145604290</noOfUnitsOutstanding>
            <approxSaleDate>11/08/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>11/08/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>36000</amountOfSecuritiesAcquired>
            <paymentDate>11/08/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHRISTOPHER FRANCIS</name>
                <address>
                    <ns2:street1>7 Straits View #12-00</ns2:street1>
                    <ns2:street2>Marina One East Tower</ns2:street2>
                    <ns2:city>Singapore</ns2:city>
                    <ns2:stateOrCountry>U0</ns2:stateOrCountry>
                    <ns2:zipCode>018936</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/16/2024</saleDate>
            <amountOfSecuritiesSold>79714</amountOfSecuritiesSold>
            <grossProceeds>1115996.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHRISTOPHER FRANCIS</name>
                <address>
                    <ns2:street1>7 Straits View #12-00</ns2:street1>
                    <ns2:street2>Marina One East Tower</ns2:street2>
                    <ns2:city>Singapore</ns2:city>
                    <ns2:stateOrCountry>U0</ns2:stateOrCountry>
                    <ns2:zipCode>018936</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/16/2024</saleDate>
            <amountOfSecuritiesSold>65625</amountOfSecuritiesSold>
            <grossProceeds>902343.75</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHRISTOPHER FRANCIS</name>
                <address>
                    <ns2:street1>7 Straits View #12-00</ns2:street1>
                    <ns2:street2>Marina One East Tower</ns2:street2>
                    <ns2:city>Singapore</ns2:city>
                    <ns2:stateOrCountry>U0</ns2:stateOrCountry>
                    <ns2:zipCode>018936</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/16/2024</saleDate>
            <amountOfSecuritiesSold>22500</amountOfSecuritiesSold>
            <grossProceeds>303750.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHRISTOPHER FRANCIS</name>
                <address>
                    <ns2:street1>7 Straits View #12-00</ns2:street1>
                    <ns2:street2>Marina One East Tower</ns2:street2>
                    <ns2:city>Singapore</ns2:city>
                    <ns2:stateOrCountry>U0</ns2:stateOrCountry>
                    <ns2:zipCode>018936</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/16/2024</saleDate>
            <amountOfSecuritiesSold>40997</amountOfSecuritiesSold>
            <grossProceeds>532961.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>11/08/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/21/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Christopher John Francis</signature>
        </noticeSignature>
    </formData>
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144
0001657709
XXXXXXXX
LIVE
0001631574
WAVE LIFE SCIENCES LTD.
001-37627
7 Straits View #12-00
Marina One East Tower
Singapore
U0
018936
65 6236 3388
CHRISTOPHER FRANCIS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
36000
576000.00
145604290
11/08/2024
NASDAQ
COMMON
11/08/2024
Stock Option Exercise
ISSUER
N
36000
11/08/2024
Cash
N
CHRISTOPHER FRANCIS
7 Straits View #12-00
Marina One East Tower
Singapore
U0
018936
Common
10/16/2024
79714
1115996.00
CHRISTOPHER FRANCIS
7 Straits View #12-00
Marina One East Tower
Singapore
U0
018936
Common
10/16/2024
65625
902343.75
CHRISTOPHER FRANCIS
7 Straits View #12-00
Marina One East Tower
Singapore
U0
018936
Common
10/16/2024
22500
303750.00
CHRISTOPHER FRANCIS
7 Straits View #12-00
Marina One East Tower
Singapore
U0
018936
Common
10/16/2024
40997
532961.00
11/08/2024
11/21/2023
/s/ Christopher John Francis