<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001278219</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001055726</issuerCik>
            <issuerName>INOVIO PHARMACEUTICALS, INC.</issuerName>
            <secFileNumber>001-14888</secFileNumber>
            <issuerAddress>
                <ns2:street1>660 W. GERMANTOWN PIKE</ns2:street1>
                <ns2:street2>Suite 110</ns2:street2>
                <ns2:city>PLYMOUTH MEETING</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19462</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(267) 440-4200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>LOTA ZOTH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>5700</noOfUnitsSold>
            <aggregateMarketValue>3213.63</aggregateMarketValue>
            <noOfUnitsOutstanding>262740113</noOfUnitsOutstanding>
            <approxSaleDate>06/05/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/16/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5700</amountOfSecuritiesAcquired>
            <paymentDate>05/16/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/05/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/06/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Lota Zoth</signature>
        </noticeSignature>
    </formData>
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144
0001278219
XXXXXXXX
LIVE
0001055726
INOVIO PHARMACEUTICALS, INC.
001-14888
660 W. GERMANTOWN PIKE
Suite 110
PLYMOUTH MEETING
PA
19462
(267) 440-4200
LOTA ZOTH
Director
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
5700
3213.63
262740113
06/05/2023
NASD
Common
05/16/2023
Restricted Stock
Issuer
N
5700
05/16/2023
Not Applicable
Y
06/05/2023
03/06/2023
/s/ Lota Zoth