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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001157601</issuerCik>
            <issuerName>MADRIGAL PHARMACEUTICALS, INC.</issuerName>
            <secFileNumber>001-33277</secFileNumber>
            <issuerAddress>
                <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                <ns2:street2>Suite 200</ns2:street2>
                <ns2:city>West Conshohocken</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19428</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(267) 824-2827</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROBERT WALTERMIRE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>14113</noOfUnitsSold>
            <aggregateMarketValue>4817104.20</aggregateMarketValue>
            <noOfUnitsOutstanding>22080246</noOfUnitsOutstanding>
            <approxSaleDate>03/05/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/27/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6825</amountOfSecuritiesAcquired>
            <paymentDate>02/27/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
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        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/27/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7288</amountOfSecuritiesAcquired>
            <paymentDate>02/27/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT WALTERMIRE</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
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            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/28/2025</saleDate>
            <amountOfSecuritiesSold>1227</amountOfSecuritiesSold>
            <grossProceeds>418488.10</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>03/05/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Robert E. Waltermire</signature>
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144
0001876996
XXXXXXXX
LIVE
0001157601
MADRIGAL PHARMACEUTICALS, INC.
001-33277
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
(267) 824-2827
ROBERT WALTERMIRE
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
14113
4817104.20
22080246
03/05/2025
NASDAQ
Common
02/27/2025
Exercise of options under a registered plan
Issuer
N
6825
02/27/2025
Cash
Common
02/27/2025
Exercise of options under a registered plan
Issuer
N
7288
02/27/2025
Cash
N
ROBERT WALTERMIRE
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
02/28/2025
1227
418488.10
03/05/2025
/s/ Robert E. Waltermire