<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001846905</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001652130</issuerCik>
            <issuerName>INTELLIA THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-37766</secFileNumber>
            <issuerAddress>
                <ns2:street1>40 Erie Street, Suite 130</ns2:street1>
                <ns2:city>Cambridge</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02139</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>857-285-6200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MUNA BHANJI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>265</noOfUnitsSold>
            <aggregateMarketValue>11217.45</aggregateMarketValue>
            <noOfUnitsOutstanding>88140978</noOfUnitsOutstanding>
            <approxSaleDate>07/31/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>07/28/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>265</amountOfSecuritiesAcquired>
            <paymentDate>07/28/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MUNA BHANJI</name>
                <address>
                    <ns2:street1>40 Erie Street, Suite 130</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02139</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/06/2023</saleDate>
            <amountOfSecuritiesSold>1867</amountOfSecuritiesSold>
            <grossProceeds>73377.77</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>07/31/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/08/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Muna Bhanji</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001846905
XXXXXXXX
LIVE
0001652130
INTELLIA THERAPEUTICS, INC.
001-37766
40 Erie Street, Suite 130
Cambridge
MA
02139
857-285-6200
MUNA BHANJI
Director
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
265
11217.45
88140978
07/31/2023
NASD
COMMON
07/28/2023
Restricted Stock
ISSUER
N
265
07/28/2023
Not Applicable
N
MUNA BHANJI
40 Erie Street, Suite 130
Cambridge
MA
02139
Common
07/06/2023
1867
73377.77
07/31/2023
03/08/2023
/s/ Muna Bhanji