<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001702265</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001658247</issuerCik>
            <issuerName>CRINETICS PHARMACEUTICALS, INC.</issuerName>
            <secFileNumber>001-38583</secFileNumber>
            <issuerAddress>
                <ns2:street1>10222 Barnes Canyon Road, Bldg. #2,</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92121</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(858) 450-6464</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MARC WILSON</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>30922</noOfUnitsSold>
            <aggregateMarketValue>617361.34</aggregateMarketValue>
            <noOfUnitsOutstanding>54026103</noOfUnitsOutstanding>
            <approxSaleDate>06/20/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>11/20/2020</acquiredDate>
            <natureOfAcquisitionTransaction>ESPP</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>702</amountOfSecuritiesAcquired>
            <paymentDate>11/20/2020</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>05/20/2022</acquiredDate>
            <natureOfAcquisitionTransaction>ESPP</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1446</amountOfSecuritiesAcquired>
            <paymentDate>05/20/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>05/20/2020</acquiredDate>
            <natureOfAcquisitionTransaction>ESPP</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>697</amountOfSecuritiesAcquired>
            <paymentDate>05/20/2020</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>11/19/2021</acquiredDate>
            <natureOfAcquisitionTransaction>ESPP</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>837</amountOfSecuritiesAcquired>
            <paymentDate>11/19/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>05/20/2019</acquiredDate>
            <natureOfAcquisitionTransaction>ESPP</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1471</amountOfSecuritiesAcquired>
            <paymentDate>05/20/2019</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>03/15/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3209</amountOfSecuritiesAcquired>
            <paymentDate>03/15/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>05/20/2021</acquiredDate>
            <natureOfAcquisitionTransaction>ESPP</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1090</amountOfSecuritiesAcquired>
            <paymentDate>05/20/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>06/20/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>20000</amountOfSecuritiesAcquired>
            <paymentDate>06/20/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>11/20/2018</acquiredDate>
            <natureOfAcquisitionTransaction>ESPP</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1470</amountOfSecuritiesAcquired>
            <paymentDate>11/20/2018</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/20/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/21/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Marc Wilson</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 7782}]
144
0001702265
XXXXXXXX
LIVE
0001658247
CRINETICS PHARMACEUTICALS, INC.
001-38583
10222 Barnes Canyon Road, Bldg. #2,
San Diego
CA
92121
(858) 450-6464
MARC WILSON
Officer
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
30922
617361.34
54026103
06/20/2023
NASD
COMMON
11/20/2020
ESPP
ISSUER
N
702
11/20/2020
Cash
COMMON
05/20/2022
ESPP
ISSUER
N
1446
05/20/2022
Cash
COMMON
05/20/2020
ESPP
ISSUER
N
697
05/20/2020
Cash
COMMON
11/19/2021
ESPP
ISSUER
N
837
11/19/2021
Cash
COMMON
05/20/2019
ESPP
ISSUER
N
1471
05/20/2019
Cash
COMMON
03/15/2023
Restricted Stock
ISSUER
N
3209
03/15/2023
Not Applicable
COMMON
05/20/2021
ESPP
ISSUER
N
1090
05/20/2021
Cash
COMMON
06/20/2023
Stock Option Exercise
ISSUER
N
20000
06/20/2023
Cash
COMMON
11/20/2018
ESPP
ISSUER
N
1470
11/20/2018
Cash
Y
06/20/2023
03/21/2023
/s/ Marc Wilson