<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001036630</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001046311</issuerCik>
            <issuerName>CHOICE HOTELS INTERNATIONAL, INC.</issuerName>
            <secFileNumber>001-13393</secFileNumber>
            <issuerAddress>
                <ns2:street1>915 Meeting Street</ns2:street1>
                <ns2:street2>Suite 600</ns2:street2>
                <ns2:city>North Bethesda</ns2:city>
                <ns2:stateOrCountry>MD</ns2:stateOrCountry>
                <ns2:zipCode>20852</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>301-592-5000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>WELLNESS ADVOCACY FUND</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>66400</noOfUnitsSold>
            <aggregateMarketValue>8372435.76</aggregateMarketValue>
            <noOfUnitsOutstanding>49560122</noOfUnitsOutstanding>
            <approxSaleDate>03/13/2024</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/01/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Gift from Affiliate</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Jane Bainum</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>Y</isGiftTransaction>
            <donarAcquiredDate>12/31/1997</donarAcquiredDate>
            <amountOfSecuritiesAcquired>66400</amountOfSecuritiesAcquired>
            <natureOfPayment>NA</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>03/13/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Barbara J Bainum</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3306}]
144
0001036630
XXXXXXXX
LIVE
0001046311
CHOICE HOTELS INTERNATIONAL, INC.
001-13393
915 Meeting Street
Suite 600
North Bethesda
MD
20852
301-592-5000
WELLNESS ADVOCACY FUND
10% Stockholder
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
66400
8372435.76
49560122
03/13/2024
NYSE
Common
01/01/2020
Gift from Affiliate
Jane Bainum
Y
12/31/1997
66400
NA
Y
03/13/2024
/s/ Barbara J Bainum