<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001727606</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0000914475</issuerCik>
            <issuerName>NEUROCRINE BIOSCIENCES INC</issuerName>
            <secFileNumber>000-22705</secFileNumber>
            <issuerAddress>
                <ns2:street1>12780 El Camino Real </ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92130</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8586177714</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Eiry Wyn Roberts</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>14400</noOfUnitsSold>
            <aggregateMarketValue>1500048.00</aggregateMarketValue>
            <noOfUnitsOutstanding>96587911</noOfUnitsOutstanding>
            <approxSaleDate>04/24/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/06/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>14400</amountOfSecuritiesAcquired>
            <paymentDate>02/06/2023</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for EIRY WYN ROBERTS</name>
                <address>
                    <ns2:street1>12780 El Camino Real </ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/08/2023</saleDate>
            <amountOfSecuritiesSold>980</amountOfSecuritiesSold>
            <grossProceeds>102072.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for EIRY WYN ROBERTS</name>
                <address>
                    <ns2:street1>12780 El Camino Real </ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/07/2023</saleDate>
            <amountOfSecuritiesSold>1623</amountOfSecuritiesSold>
            <grossProceeds>166114.05</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for EIRY WYN ROBERTS</name>
                <address>
                    <ns2:street1>12780 El Camino Real </ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/07/2023</saleDate>
            <amountOfSecuritiesSold>12801</amountOfSecuritiesSold>
            <grossProceeds>1310918.41</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for EIRY WYN ROBERTS</name>
                <address>
                    <ns2:street1>12780 El Camino Real </ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/06/2023</saleDate>
            <amountOfSecuritiesSold>1121</amountOfSecuritiesSold>
            <grossProceeds>118602.25</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for EIRY WYN ROBERTS</name>
                <address>
                    <ns2:street1>12780 El Camino Real </ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/31/2023</saleDate>
            <amountOfSecuritiesSold>1457</amountOfSecuritiesSold>
            <grossProceeds>160253.54</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>Shares acquired from 2/6/2023 thru 2/8/2023</remarks>
        <noticeSignature>
            <noticeDate>04/24/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/23/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Eiry Wyn Roberts</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6979}]
144
0001727606
XXXXXXXX
LIVE
0000914475
NEUROCRINE BIOSCIENCES INC
000-22705
12780 El Camino Real
San Diego
CA
92130
8586177714
Eiry Wyn Roberts
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
14400
1500048.00
96587911
04/24/2023
NASDAQ
Common
02/06/2023
Restricted Stock Units
Issuer
N
14400
02/06/2023
N/A
N
10b5-1 Sales Plan for EIRY WYN ROBERTS
12780 El Camino Real
San Diego
CA
92130
Common
02/08/2023
980
102072.00
10b5-1 Sales Plan for EIRY WYN ROBERTS
12780 El Camino Real
San Diego
CA
92130
Common
02/07/2023
1623
166114.05
10b5-1 Sales Plan for EIRY WYN ROBERTS
12780 El Camino Real
San Diego
CA
92130
Common
02/07/2023
12801
1310918.41
10b5-1 Sales Plan for EIRY WYN ROBERTS
12780 El Camino Real
San Diego
CA
92130
Common
02/06/2023
1121
118602.25
10b5-1 Sales Plan for EIRY WYN ROBERTS
12780 El Camino Real
San Diego
CA
92130
Common
01/31/2023
1457
160253.54
Shares acquired from 2/6/2023 thru 2/8/2023
04/24/2023
02/23/2023
/s/ Eiry Wyn Roberts