<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001727606</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0000914475</issuerCik>
            <issuerName>NEUROCRINE BIOSCIENCES, INC.</issuerName>
            <secFileNumber>000-22705</secFileNumber>
            <issuerAddress>
                <ns2:street1>6027 Edgewood Bend Court</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92130</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(858) 617-7600</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>EIRY WYN ROBERTS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>500</noOfUnitsSold>
            <aggregateMarketValue>57521.25</aggregateMarketValue>
            <noOfUnitsOutstanding>99703527</noOfUnitsOutstanding>
            <approxSaleDate>02/14/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/13/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Employee stock unit award(s)</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>500</amountOfSecuritiesAcquired>
            <paymentDate>02/14/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Eiry Roberts</name>
                <address>
                    <ns2:street1>6027 Edgewood Bend Court</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/13/2025</saleDate>
            <amountOfSecuritiesSold>880</amountOfSecuritiesSold>
            <grossProceeds>102718.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Eiry Roberts</name>
                <address>
                    <ns2:street1>6027 Edgewood Bend Court</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/10/2025</saleDate>
            <amountOfSecuritiesSold>980</amountOfSecuritiesSold>
            <grossProceeds>115784.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Eiry Roberts</name>
                <address>
                    <ns2:street1>6027 Edgewood Bend Court</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92130</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/31/2025</saleDate>
            <amountOfSecuritiesSold>1457</amountOfSecuritiesSold>
            <grossProceeds>222536.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>02/14/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Eiry Wyn Roberts</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5313}]
144
0001727606
XXXXXXXX
LIVE
0000914475
NEUROCRINE BIOSCIENCES, INC.
000-22705
6027 Edgewood Bend Court
San Diego
CA
92130
(858) 617-7600
EIRY WYN ROBERTS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
500
57521.25
99703527
02/14/2025
NASDAQ
Common
02/13/2025
Employee stock unit award(s)
Issuer
N
500
02/14/2025
Cash
N
Eiry Roberts
6027 Edgewood Bend Court
San Diego
CA
92130
Common
02/13/2025
880
102718.00
Eiry Roberts
6027 Edgewood Bend Court
San Diego
CA
92130
Common
02/10/2025
980
115784.00
Eiry Roberts
6027 Edgewood Bend Court
San Diego
CA
92130
Common
01/31/2025
1457
222536.00
02/14/2025
/s/ Eiry Wyn Roberts