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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>001-40606</secFileNumber>
            <issuerAddress>
                <ns2:street1>2749 East Parleys Way, Suite 200</ns2:street1>
                <ns2:city>Salt Lake City</ns2:city>
                <ns2:stateOrCountry>UT</ns2:stateOrCountry>
                <ns2:zipCode>84109</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8019900520</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>AUSTIN AERTS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>20000</noOfUnitsSold>
            <aggregateMarketValue>166400.00</aggregateMarketValue>
            <noOfUnitsOutstanding>32804741</noOfUnitsOutstanding>
            <approxSaleDate>01/10/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/25/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>20000</amountOfSecuritiesAcquired>
            <paymentDate>03/25/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <address>
                    <ns2:street1>2749 East Parleys Way, Suite 200</ns2:street1>
                    <ns2:city>Salt Lake City</ns2:city>
                    <ns2:stateOrCountry>UT</ns2:stateOrCountry>
                    <ns2:zipCode>84109</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/10/2024</saleDate>
            <amountOfSecuritiesSold>5730</amountOfSecuritiesSold>
            <grossProceeds>42459.30</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>AUSTIN AERTS</name>
                <address>
                    <ns2:street1>2749 East Parleys Way, Suite 200</ns2:street1>
                    <ns2:city>Salt Lake City</ns2:city>
                    <ns2:stateOrCountry>UT</ns2:stateOrCountry>
                    <ns2:zipCode>84109</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/11/2024</saleDate>
            <amountOfSecuritiesSold>7179</amountOfSecuritiesSold>
            <grossProceeds>52550.28</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>01/10/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/22/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Austin Aerts</signature>
        </noticeSignature>
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144
0001979974
XXXXXXXX
LIVE
0001534969
SERA PROGNOSTICS INC
001-40606
2749 East Parleys Way, Suite 200
Salt Lake City
UT
84109
8019900520
AUSTIN AERTS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
20000
166400.00
32804741
01/10/2025
NASDAQ
Common
03/25/2024
Restricted Stock Units
Issuer
N
20000
03/25/2024
N/A
N
AUSTIN AERTS
2749 East Parleys Way, Suite 200
Salt Lake City
UT
84109
Common
12/10/2024
5730
42459.30
AUSTIN AERTS
2749 East Parleys Way, Suite 200
Salt Lake City
UT
84109
Common
11/11/2024
7179
52550.28
01/10/2025
05/22/2024
/s/ Austin Aerts