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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001609550</issuerCik>
            <issuerName>INSPIRE MEDICAL SYSTEMS, INC.</issuerName>
            <secFileNumber>001-38468</secFileNumber>
            <issuerAddress>
                <ns2:street1>5500 Wayzata Blvd. Suite 1600</ns2:street1>
                <ns2:city>Golden Valley</ns2:city>
                <ns2:stateOrCountry>MN</ns2:stateOrCountry>
                <ns2:zipCode>55416</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(844) 672-4357</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SHAWN T MCCORMICK</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>800</noOfUnitsSold>
            <aggregateMarketValue>176000.00</aggregateMarketValue>
            <noOfUnitsOutstanding>29821707</noOfUnitsOutstanding>
            <approxSaleDate>09/09/2024</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>03/17/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Exercised Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>800</amountOfSecuritiesAcquired>
            <paymentDate>03/17/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>09/09/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/24/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Shawn T McCormick</signature>
        </noticeSignature>
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144
0001454092
XXXXXXXX
LIVE
0001609550
INSPIRE MEDICAL SYSTEMS, INC.
001-38468
5500 Wayzata Blvd. Suite 1600
Golden Valley
MN
55416
(844) 672-4357
SHAWN T MCCORMICK
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
800
176000.00
29821707
09/09/2024
NYSE
COMMON
03/17/2023
Exercised Shares
ISSUER
N
800
03/17/2023
Cash
Y
09/09/2024
05/24/2024
/s/ Shawn T McCormick