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        <com:stateOrCountry>CT</com:stateOrCountry>
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        <address>
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          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
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      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
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      <natureOfAcquisitionTransaction>Compensation for Sale of GeneDX to Sema 4</natureOfAcquisitionTransaction>
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        <name>Opko Health, INC</name>
        <address>
          <com:street1>333 Ludlow Street, North Tower,</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>09/16/2024</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>1878619.49</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Opko Health, INC</name>
        <address>
          <com:street1>333 Ludlow Street, North Tower,</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>09/17/2024</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>1874392.75</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Adam Logal is authorized agent for Opko Health Weekly volume per Yahoo Finance 9/9/24 - 1,888,400 9/2/24- 1,432,500 8/26/24- 1,710,800 8/19/24- 1,722,800 4wk avg volume LATE FILLING FOR A TRADE ON 9-17-24</remarks>
    <noticeSignature>
      <noticeDate>09/20/2024</noticeDate>
      <signature>Adam Logal</signature>
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144
0000944809
XXXXXXXX
LIVE
0001818331
GeneDx Holdings Corp.
001-39482
333 LUDLOW STREET
NORTH TOWER, 6TH FLOOR
STAMFORD
CT
06902
8887291206
OPKO HEALTH, INC.
10% Stockholder
Class A Common Stock
Charles Schwab & Co.
3000 Schwab Way
Westlake
TX
76262
13404
547955.52
26935897
09/17/2024
Nasdaq
Class A Common Stock
04/29/2022
Compensation for Sale of GeneDX to Sema 4
Issuer
N
13404
04/29/2022
N/a
N
Opko Health, INC
333 Ludlow Street, North Tower
6th Floor
Stamford
CT
06902
Class A Common Stock
07/01/2024
50000
1331629.33
Opko Health, INC
333 Ludlow Street, North Tower
6th Floor
Stamford
CT
06902
Class A Common Stock
07/02/2024
25000
728045.85
Opko Health, INC
333 Ludlow Street, North Tower
6th Floor
Stamford
CT
06902
Class A Common Stock
07/03/2024
14082
397427.18
Opko Health, INC
333 Ludlow Street, North Tower
6th Floor
Stamford
CT
06902
Class A Common Stock
07/05/2024
36118
1019956.04
Opko Health, INC
333 Ludlow Street, North Tower
6th Floor
Stamford
CT
06902
Class A Common Stock
07/17/2024
25000
823134.63
Opko Health, INC
333 Ludlow Street, North Tower
6th Floor
Stamford
CT
06902
Class A Common Stock
07/19/2024
25000
807193.41
Opko Health, INC
333 Ludlow Street, North Tower
6th Floor
Stamford
CT
06902
Class A Common Stock
07/22/2024
50000
1630338.88
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
07/23/2024
75000
2509095.52
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
07/24/2024
75000
2528928.90
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
07/26/2024
60000
2031110.15
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
07/29/2024
50000
1692809.79
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
07/31/2024
88839
2976129.26
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/06/2024
12994
381377.69
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/08/2024
100000
3158971.43
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/12/2024
59787
2029629.56
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/13/2024
24987
868451.66
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/15/2024
39824
1317441.91
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/16/2024
50000
1714770.62
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/19/2024
50000
1724437.49
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/21/2024
94826
3270053.20
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/22/2024
25000
851893.73
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/23/2024
25000
884412.73
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/26/2024
10000
348575.15
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/26/2024
10000
348575.15
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
08/29/2024
4461
147328.27
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
09/04/2024
7345
232558.80
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
09/09/2024
50000
1668188.68
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
09/11/2024
50000
1743233.71
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
09/12/2024
100000
3828672.85
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
09/13/2024
8666
331769.47
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
09/16/2024
50000
1878619.49
Opko Health, INC
333 Ludlow Street, North Tower,
6th Floor
Stamford
CT
06902
Class A Common Stock
09/17/2024
50000
1874392.75
Adam Logal is authorized agent for Opko Health Weekly volume per Yahoo Finance 9/9/24 - 1,888,400 9/2/24- 1,432,500 8/26/24- 1,710,800 8/19/24- 1,722,800 4wk avg volume LATE FILLING FOR A TRADE ON 9-17-24
09/20/2024
Adam Logal