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            <secFileNumber>001-39450</secFileNumber>
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                <ns2:zipCode>19462</ns2:zipCode>
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                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
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                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
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            <noOfUnitsOutstanding>57031297</noOfUnitsOutstanding>
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            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <paymentDate>01/24/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
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                    <ns2:zipCode>19462</ns2:zipCode>
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                    <ns2:zipCode>19462</ns2:zipCode>
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            <amountOfSecuritiesSold>29475</amountOfSecuritiesSold>
            <grossProceeds>1102795.34</grossProceeds>
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        <securitiesSoldInPast3Months>
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                    <ns2:city>Plymouth Meeting</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19462</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
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            <grossProceeds>265946.60</grossProceeds>
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                    <ns2:zipCode>19462</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/29/2024</saleDate>
            <amountOfSecuritiesSold>21496</amountOfSecuritiesSold>
            <grossProceeds>870018.44</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>01/27/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/27/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jeffrey G. Dierks</signature>
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144
0001821102
XXXXXXXX
LIVE
0001802665
HARMONY BIOSCIENCES HLDGS INC
001-39450
630 W Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
4845399800
JEFFREY G DIERKS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
1629
61918.29
57031297
01/27/2025
NASDAQ
Common
01/24/2025
Restricted Stock Units
Issuer
N
1629
01/24/2025
N/A
N
10b5-1 Sales for JEFFREY G DIERKS
630 W Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
01/24/2025
13125
489634.69
10b5-1 Sales for JEFFREY G DIERKS
630 W Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
01/21/2025
1123
44920.00
10b5-1 Sales for JEFFREY G DIERKS
630 W Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
01/16/2025
29475
1102795.34
10b5-1 Sales for JEFFREY G DIERKS
630 W Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
01/15/2025
10507
388840.72
10b5-1 Sales for JEFFREY G DIERKS
630 W Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
01/13/2025
7180
265946.60
10b5-1 Sales for JEFFREY G DIERKS
630 W Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
10/29/2024
21496
870018.44
01/27/2025
08/27/2024
/s/ Jeffrey G. Dierks