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      <filer>
        <filerCredentials>
          <cik>0001677686</cik>
          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



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    <issuerInfo>
      <issuerCik>0001423689</issuerCik>
      <issuerName>AGNC Investment Corp.</issuerName>
      <secFileNumber>001-34057</secFileNumber>
      <issuerAddress>
        <com:street1>2 BETHESDA METRO CENTER 12TH FLOOR</com:street1>
        <com:city>BETHESDA</com:city>
        <com:stateOrCountry>MD</com:stateOrCountry>
        <com:zipCode>20814</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>301 968 9300</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Pollack Kenneth L.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>7003</noOfUnitsSold>
      <aggregateMarketValue>69330.40</aggregateMarketValue>
      <noOfUnitsOutstanding>574656885</noOfUnitsOutstanding>
      <approxSaleDate>04/26/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/09/2016</acquiredDate>
      <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1000</amountOfSecuritiesAcquired>
      <paymentDate>12/09/2016</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/15/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>5090</amountOfSecuritiesAcquired>
      <paymentDate>03/15/2021</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/15/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>913</amountOfSecuritiesAcquired>
      <paymentDate>03/15/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kenneth Pollack</name>
        <address>
          <com:street1>2 Bethesda Metro Center</com:street1>
          <com:street2>12th Floor</com:street2>
          <com:city>Bethesda</com:city>
          <com:stateOrCountry>MD</com:stateOrCountry>
          <com:zipCode>20814</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/15/2023</saleDate>
      <amountOfSecuritiesSold>10910</amountOfSecuritiesSold>
      <grossProceeds>123719.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>04/26/2023</noticeDate>
      <signature>/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Kenneth Pollack</signature>
    </noticeSignature>
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144
0001677686
XXXXXXXX
LIVE
0001423689
AGNC Investment Corp.
001-34057
2 BETHESDA METRO CENTER 12TH FLOOR
BETHESDA
MD
20814
301 968 9300
Pollack Kenneth L.
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
7003
69330.40
574656885
04/26/2023
NASDAQ
Common
12/09/2016
Open Market Purchase
Issuer
N
1000
12/09/2016
Cash
Common
03/15/2021
Restricted Stock Vesting
Issuer
N
5090
03/15/2021
Compensation
Common
03/15/2022
Restricted Stock Vesting
Issuer
N
913
03/15/2022
Compensation
N
Kenneth Pollack
2 Bethesda Metro Center
12th Floor
Bethesda
MD
20814
Common
02/15/2023
10910
123719.40
04/26/2023
/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Kenneth Pollack