<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001350000</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001478242</issuerCik>
      <issuerName>IQVIA HOLDINGS INC.</issuerName>
      <secFileNumber>001-35907</secFileNumber>
      <issuerAddress>
        <com:street1>2400 ELLIS ROAD</com:street1>
        <com:city>DURHAM</com:city>
        <com:stateOrCountry>NC</com:stateOrCountry>
        <com:zipCode>27703</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>919-998-2000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Knightly Kevin C</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab Corporation</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>5821</noOfUnitsSold>
      <aggregateMarketValue>1152732.00</aggregateMarketValue>
      <noOfUnitsOutstanding>185549128</noOfUnitsOutstanding>
      <approxSaleDate>05/25/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/13/2019</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>358</amountOfSecuritiesAcquired>
      <paymentDate>02/09/2022</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/09/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4240</amountOfSecuritiesAcquired>
      <paymentDate>02/09/2022</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/09/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1223</amountOfSecuritiesAcquired>
      <paymentDate>02/09/2022</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/25/2023</noticeDate>
      <signature>Kevin Kightly</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3793}]
144
0001350000
XXXXXXXX
LIVE
0001478242
IQVIA HOLDINGS INC.
001-35907
2400 ELLIS ROAD
DURHAM
NC
27703
919-998-2000
Knightly Kevin C
Officer
Common
Charles Schwab Corporation
3000 Schwab Way
Westlake
TX
76262
5821
1152732.00
185549128
05/25/2023
NYSE
Common
02/13/2019
Restricted Stock Award
Issuer
N
358
02/09/2022
Equity Compensation
Common
02/09/2022
Restricted Stock Award
Issuer
N
4240
02/09/2022
Equity Compensation
Common
02/09/2022
Restricted Stock Award
Issuer
N
1223
02/09/2022
Equity Compensation
Y
05/25/2023
Kevin Kightly