<?xml version="1.0" encoding="UTF-8"?><ns2:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:ns2="http://www.sec.gov/edgar/ownership">
    <ns2:headerData>
        <ns2:submissionType>144</ns2:submissionType>
        <ns2:filerInfo>
            <ns2:filer>
                <ns2:filerCredentials>
                    <ns2:cik>0001780851</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
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            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



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    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0001478320</ns2:issuerCik>
            <ns2:issuerName>Adaptive Biotechnologies Corporation</ns2:issuerName>
            <ns2:secFileNumber>001-38957</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>1165 Eastlake Avenue East</com:street1>
                <com:city>Seattle</com:city>
                <com:stateOrCountry>WA</com:stateOrCountry>
                <com:zipCode>98109</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>1-206-659-0067</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Harlan Robins</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Officer</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>68412</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>503512.32</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>151916722</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>05/01/2025</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:acquiredDate>06/09/2015</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired as compensation -- Stock Options</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>68412</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>06/09/2015</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation -- Cashless exercise / same-day sale</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Harlan Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>03/24/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>1698</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>15283.36</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:remarks>The sales of shares set forth herein are made in connection with a selling plan dated 8/26/2024, that is intended to comply with Rule 10b501(c). </ns2:remarks>
        <ns2:noticeSignature>
            <ns2:noticeDate>05/01/2025</ns2:noticeDate>
            <ns2:planAdoptionDates>
                <ns2:planAdoptionDate>08/26/2024</ns2:planAdoptionDate>
            </ns2:planAdoptionDates>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of Harlan Robins</ns2:signature>
        </ns2:noticeSignature>
    </ns2:formData>
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144
0001780851
XXXXXXXX
LIVE
0001478320
Adaptive Biotechnologies Corporation
001-38957
1165 Eastlake Avenue East
Seattle
WA
98109
1-206-659-0067
Harlan Robins
Officer
Common Stock
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
68412
503512.32
151916722
05/01/2025
NASD
Common Stock
06/09/2015
Acquired as compensation -- Stock Options
Issuer
N
68412
06/09/2015
Compensation -- Cashless exercise / same-day sale
N
Harlan Robins
1165 Eastlake Avenue East
Seattle
WA
98109
Common Stock
03/24/2025
1698
15283.36
The sales of shares set forth herein are made in connection with a selling plan dated 8/26/2024, that is intended to comply with Rule 10b501(c).
05/01/2025
08/26/2024
Goldman Sachs & Co. LLC on behalf of Harlan Robins