<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001800668</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001628171</issuerCik>
            <issuerName>Revolution Medicines, Inc.</issuerName>
            <secFileNumber>001-39219</secFileNumber>
            <issuerAddress>
                <ns2:street1>700 Saginaw Drive </ns2:street1>
                <ns2:city>Redwood City</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94063</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>650-481-6801</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JACK LEE ANDERS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>10000</noOfUnitsSold>
            <aggregateMarketValue>391900.00</aggregateMarketValue>
            <noOfUnitsOutstanding>164690408</noOfUnitsOutstanding>
            <approxSaleDate>05/03/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/03/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
            <paymentDate>05/03/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The date of acquisition and payment was and will be the date of exercise/sale.
</remarks>
        <noticeSignature>
            <noticeDate>05/03/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/27/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jack Lee Anders</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001800668
XXXXXXXX
LIVE
0001628171
Revolution Medicines, Inc.
001-39219
700 Saginaw Drive
Redwood City
CA
94063
650-481-6801
JACK LEE ANDERS
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
10000
391900.00
164690408
05/03/2024
NASDAQ
Common
05/03/2024
Exercise of Stock Options
Issuer
N
10000
05/03/2024
Cash
Y
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The date of acquisition and payment was and will be the date of exercise/sale.
05/03/2024
03/27/2023
/s/ Jack Lee Anders