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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001815442</issuerCik>
            <issuerName>KYMERA THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-39460</secFileNumber>
            <issuerAddress>
                <ns2:street1>500 North Beacon Street, 4th Floor</ns2:street1>
                <ns2:city>Watertown</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02472</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8572855300</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ELENA RIDLOFF</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>4500</noOfUnitsSold>
            <aggregateMarketValue>218700.00</aggregateMarketValue>
            <noOfUnitsOutstanding>65119568</noOfUnitsOutstanding>
            <approxSaleDate>06/11/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/11/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>4500</amountOfSecuritiesAcquired>
            <paymentDate>06/11/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ELENA RIDLOFF</name>
                <address>
                    <ns2:street1>500 North Beacon Street, 4th Floor</ns2:street1>
                    <ns2:city>Watertown</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02472</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/03/2025</saleDate>
            <amountOfSecuritiesSold>12000</amountOfSecuritiesSold>
            <grossProceeds>553200.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/11/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/25/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Elena Ridloff</signature>
        </noticeSignature>
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144
0001772518
XXXXXXXX
LIVE
0001815442
KYMERA THERAPEUTICS, INC.
001-39460
500 North Beacon Street, 4th Floor
Watertown
MA
02472
8572855300
ELENA RIDLOFF
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
4500
218700.00
65119568
06/11/2025
NASDAQ
Common
06/11/2025
Exercise of Stock Options
Issuer
N
4500
06/11/2025
Cash
N
10b5-1 Sales for ELENA RIDLOFF
500 North Beacon Street, 4th Floor
Watertown
MA
02472
Common
06/03/2025
12000
553200.00
06/11/2025
11/25/2024
/s/ Elena Ridloff