<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001181556</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001599901</issuerCik>
            <issuerName>AVIDITY BIOSCIENCES INC</issuerName>
            <secFileNumber>001-39321</secFileNumber>
            <issuerAddress>
                <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92121</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8584017900</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ARTHUR A LEVIN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>8323</noOfUnitsSold>
            <aggregateMarketValue>419895.35</aggregateMarketValue>
            <noOfUnitsOutstanding>109801397</noOfUnitsOutstanding>
            <approxSaleDate>10/21/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>10/21/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>8323</amountOfSecuritiesAcquired>
            <paymentDate>10/21/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ARTHUR A LEVIN</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/19/2024</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>228658.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ARTHUR A LEVIN</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/19/2024</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>225946.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>10/21/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/26/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Arthur A Levin</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5011}]
144
0001181556
XXXXXXXX
LIVE
0001599901
AVIDITY BIOSCIENCES INC
001-39321
10578 Science Center Drive, Suite 125
San Diego
CA
92121
8584017900
ARTHUR A LEVIN
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
8323
419895.35
109801397
10/21/2024
NASDAQ
Common
10/21/2024
Exercise of Stock Options
Issuer
N
8323
10/21/2024
Cash
N
10b5-1 Sales for ARTHUR A LEVIN
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
09/19/2024
5000
228658.00
10b5-1 Sales for ARTHUR A LEVIN
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
08/19/2024
5000
225946.50
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
10/21/2024
05/26/2023
/s/ Arthur A Levin