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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0000883984</issuerCik>
            <issuerName>ICU MEDICAL INC.</issuerName>
            <secFileNumber>001-34634</secFileNumber>
            <issuerAddress>
                <ns2:street1>951 Calle Amanecer</ns2:street1>
                <ns2:city>San Clemente</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92673</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(949) 366-2183</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>VIRGINIA SANZONE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>250</noOfUnitsSold>
            <aggregateMarketValue>43750.00</aggregateMarketValue>
            <noOfUnitsOutstanding>23998252</noOfUnitsOutstanding>
            <approxSaleDate>04/11/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/06/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Corporate Stock Plan/Benefit Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>250</amountOfSecuritiesAcquired>
            <paymentDate>03/06/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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            <sellerDetails>
                <name>Virginia Sanzone</name>
                <address>
                    <ns2:street1>951 Calle Amanecer</ns2:street1>
                    <ns2:city>San Clemente</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92673</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/05/2023</saleDate>
            <amountOfSecuritiesSold>458</amountOfSecuritiesSold>
            <grossProceeds>77860.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/11/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/19/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Virginia Ruth Sanzone</signature>
        </noticeSignature>
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144
0001669639
XXXXXXXX
LIVE
0000883984
ICU MEDICAL INC.
001-34634
951 Calle Amanecer
San Clemente
CA
92673
(949) 366-2183
VIRGINIA SANZONE
Officer
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
250
43750.00
23998252
04/11/2023
NASDAQ
Common
03/06/2021
Corporate Stock Plan/Benefit Plan
Issuer
N
250
03/06/2021
Cash
N
Virginia Sanzone
951 Calle Amanecer
San Clemente
CA
92673
Common
04/05/2023
458
77860.00
04/11/2023
08/19/2022
/s/ Virginia Ruth Sanzone