<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001513019</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001503584</issuerCik>
            <issuerName>COSTAMARE INC.</issuerName>
            <secFileNumber>001-34934</secFileNumber>
            <issuerAddress>
                <ns2:street1>Republic of The Marshall Islands</ns2:street1>
                <ns2:city>7 Rue du Gabian</ns2:city>
                <ns2:stateOrCountry>O9</ns2:stateOrCountry>
                <ns2:zipCode>MC 98000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>377-93-25-09-40</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CHRISTOS KONSTANTAKOPOULOS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>137135</noOfUnitsSold>
            <aggregateMarketValue>2123946.88</aggregateMarketValue>
            <noOfUnitsOutstanding>118374623</noOfUnitsOutstanding>
            <approxSaleDate>06/06/2024</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/22/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Dividend in Kind</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Vasska Maritime Investments S.A.</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>137135</amountOfSecuritiesAcquired>
            <paymentDate>11/22/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHRISTOS KONSTANTAKOPOULOS</name>
                <address>
                    <ns2:street1>Republic of The Marshall Islands</ns2:street1>
                    <ns2:city>7 Rue du Gabian</ns2:city>
                    <ns2:stateOrCountry>O9</ns2:stateOrCountry>
                    <ns2:zipCode>MC 98000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/05/2024</saleDate>
            <amountOfSecuritiesSold>150000</amountOfSecuritiesSold>
            <grossProceeds>2399460.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/06/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Christos Konstantakopoulos</signature>
        </noticeSignature>
    </formData>
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144
0001513019
XXXXXXXX
LIVE
0001503584
COSTAMARE INC.
001-34934
Republic of The Marshall Islands
7 Rue du Gabian
O9
MC 98000
377-93-25-09-40
CHRISTOS KONSTANTAKOPOULOS
10% Stockholder
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
137135
2123946.88
118374623
06/06/2024
NYSE
Common
11/22/2022
Dividend in Kind
Vasska Maritime Investments S.A.
N
137135
11/22/2022
Not Applicable
N
CHRISTOS KONSTANTAKOPOULOS
Republic of The Marshall Islands
7 Rue du Gabian
O9
MC 98000
Common
06/05/2024
150000
2399460.00
06/06/2024
/s/ Christos Konstantakopoulos