<?xml version="1.0" encoding="UTF-8"?><ns2:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:ns2="http://www.sec.gov/edgar/ownership">
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                    <ns2:ccc>XXXXXXXX</ns2:ccc>
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            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



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    </ns2:headerData>
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        <ns2:issuerInfo>
            <ns2:issuerCik>0001650648</ns2:issuerCik>
            <ns2:issuerName>4D Molecular Therapeutics, Inc.</ns2:issuerName>
            <ns2:secFileNumber>001-39782</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>5858 Horton Street</com:street1>
                <com:street2>Suite 455</com:street2>
                <com:city>Emeryville</com:city>
                <com:stateOrCountry>CA</com:stateOrCountry>
                <com:zipCode>94608</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>1-510-505-2680</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>David Kirn</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Officer</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>Class A Common</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>28237</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>553162.83</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>42753607</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>01/05/2024</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Class A Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>12/15/2020</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Founder's Shares</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>28237</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>12/15/2020</ns2:paymentDate>
            <ns2:natureOfPayment>None</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>David Kirn</ns2:name>
                <ns2:address>
                    <com:street1>5858 Horton Street</com:street1>
                    <com:street2>Suite 455</com:street2>
                    <com:city>Emeryville</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>94608</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Class A Common</ns2:securitiesClassTitle>
            <ns2:saleDate>01/04/2024</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>40732</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>827201.75</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>David Kirn</ns2:name>
                <ns2:address>
                    <com:street1>5858 Horton Street</com:street1>
                    <com:street2>Suite 455</com:street2>
                    <com:city>Emeryville</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>94608</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Class A Common</ns2:securitiesClassTitle>
            <ns2:saleDate>12/15/2023</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>28632</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>494431.69</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>David Kirn</ns2:name>
                <ns2:address>
                    <com:street1>5858 Horton Street</com:street1>
                    <com:street2>Suite 455</com:street2>
                    <com:city>Emeryville</com:city>
                    <com:stateOrCountry>CA</com:stateOrCountry>
                    <com:zipCode>94608</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Class A Common</ns2:securitiesClassTitle>
            <ns2:saleDate>12/18/2023</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>4702</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>85242.56</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:remarks>The sales of shares set forth herein are made in connection with a selling plan dated 8/17/2023, that is intended to comply with Rule 10b5-1(c).</ns2:remarks>
        <ns2:noticeSignature>
            <ns2:noticeDate>01/05/2024</ns2:noticeDate>
            <ns2:planAdoptionDates>
                <ns2:planAdoptionDate>08/17/2023</ns2:planAdoptionDate>
            </ns2:planAdoptionDates>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of David Kirn</ns2:signature>
        </ns2:noticeSignature>
    </ns2:formData>
</ns2:edgarSubmission>
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144
0001834021
XXXXXXXX
LIVE
0001650648
4D Molecular Therapeutics, Inc.
001-39782
5858 Horton Street
Suite 455
Emeryville
CA
94608
1-510-505-2680
David Kirn
Officer
Class A Common
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
28237
553162.83
42753607
01/05/2024
NASD
Class A Common
12/15/2020
Founder's Shares
Issuer
N
28237
12/15/2020
None
N
David Kirn
5858 Horton Street
Suite 455
Emeryville
CA
94608
Class A Common
01/04/2024
40732
827201.75
David Kirn
5858 Horton Street
Suite 455
Emeryville
CA
94608
Class A Common
12/15/2023
28632
494431.69
David Kirn
5858 Horton Street
Suite 455
Emeryville
CA
94608
Class A Common
12/18/2023
4702
85242.56
The sales of shares set forth herein are made in connection with a selling plan dated 8/17/2023, that is intended to comply with Rule 10b5-1(c).
01/05/2024
08/17/2023
Goldman Sachs & Co. LLC on behalf of David Kirn