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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001178879</issuerCik>
            <issuerName>AMICUS THERAPEUTICS INC</issuerName>
            <secFileNumber>001-33497</secFileNumber>
            <issuerAddress>
                <ns2:street1>47 Hulfish Street</ns2:street1>
                <ns2:city>Princeton</ns2:city>
                <ns2:stateOrCountry>NJ</ns2:stateOrCountry>
                <ns2:zipCode>08542</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6096622000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BRADLEY CAMPBELL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>400</noOfUnitsSold>
            <aggregateMarketValue>3940.00</aggregateMarketValue>
            <noOfUnitsOutstanding>298805773</noOfUnitsOutstanding>
            <approxSaleDate>02/19/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/19/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>400</amountOfSecuritiesAcquired>
            <paymentDate>02/19/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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            <sellerDetails>
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                <address>
                    <ns2:street1>47 Hulfish Street</ns2:street1>
                    <ns2:city>Princeton</ns2:city>
                    <ns2:stateOrCountry>NJ</ns2:stateOrCountry>
                    <ns2:zipCode>08542</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>12/02/2024</saleDate>
            <amountOfSecuritiesSold>7500</amountOfSecuritiesSold>
            <grossProceeds>75124.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>02/19/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/13/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Bradley Campbell</signature>
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144
0001400971
XXXXXXXX
LIVE
0001178879
AMICUS THERAPEUTICS INC
001-33497
47 Hulfish Street
Princeton
NJ
08542
6096622000
BRADLEY CAMPBELL
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
400
3940.00
298805773
02/19/2025
NASDAQ
Common
02/19/2025
Exercise of Stock Options
Issuer
N
400
02/19/2025
Cash
N
10b5-1 Sales Plan for BRADLEY CAMPBELL
47 Hulfish Street
Princeton
NJ
08542
COMMON
12/02/2024
7500
75124.50
02/19/2025
09/13/2024
/s/ Bradley Campbell