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      <liveTestFlag>LIVE</liveTestFlag>



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      <issuerCik>0000103145</issuerCik>
      <issuerName>VEECO INSTRUMENTS INC</issuerName>
      <secFileNumber>000-16244</secFileNumber>
      <issuerAddress>
        <com:street1>TERMINAL DRIVE</com:street1>
        <com:city>PLAINVIEW</com:city>
        <com:stateOrCountry>NY</com:stateOrCountry>
        <com:zipCode>11803</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>516 677-0200</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SIMONE PETER J</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>10000</noOfUnitsSold>
      <aggregateMarketValue>251522.48</aggregateMarketValue>
      <noOfUnitsOutstanding>51692973</noOfUnitsOutstanding>
      <approxSaleDate>06/09/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/05/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4622</amountOfSecuritiesAcquired>
      <paymentDate>05/05/2021</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/07/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>5378</amountOfSecuritiesAcquired>
      <paymentDate>05/07/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>PETER SIMONE</name>
        <address>
          <com:street1>Terminal Drive</com:street1>
          <com:city>Plainview</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>11803</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/24/2023</saleDate>
      <amountOfSecuritiesSold>19929</amountOfSecuritiesSold>
      <grossProceeds>448881.47</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/09/2023</noticeDate>
      <signature>/s/ Rae Pierson, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Peter Simone</signature>
    </noticeSignature>
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144
0001194518
XXXXXXXX
LIVE
0000103145
VEECO INSTRUMENTS INC
000-16244
TERMINAL DRIVE
PLAINVIEW
NY
11803
516 677-0200
SIMONE PETER J
Director
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
10000
251522.48
51692973
06/09/2023
NASDAQ
Common
05/05/2021
Restricted Stock Vesting
Issuer
N
4622
05/05/2021
Compensation
Common
05/07/2022
Restricted Stock Vesting
Issuer
N
5378
05/07/2022
Compensation
N
PETER SIMONE
Terminal Drive
Plainview
NY
11803
Common
05/24/2023
19929
448881.47
06/09/2023
/s/ Rae Pierson, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Peter Simone