<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001618364</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001841387</issuerCik>
            <issuerName>CANDEL THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-40629</secFileNumber>
            <issuerAddress>
                <ns2:street1>117 Kendrick St, Suite 450</ns2:street1>
                <ns2:city>Needham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02494</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6179165445</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>WILLIAM GARRETT NICHOLS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>3593</noOfUnitsSold>
            <aggregateMarketValue>17605.70</aggregateMarketValue>
            <noOfUnitsOutstanding>50102679</noOfUnitsOutstanding>
            <approxSaleDate>06/30/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/30/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3593</amountOfSecuritiesAcquired>
            <paymentDate>06/30/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>06/30/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/22/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ William Garrett Nichols</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001618364
XXXXXXXX
LIVE
0001841387
CANDEL THERAPEUTICS, INC.
001-40629
117 Kendrick St, Suite 450
Needham
MA
02494
6179165445
WILLIAM GARRETT NICHOLS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
3593
17605.70
50102679
06/30/2025
NASDAQ
Common
06/30/2025
Exercise of Stock Options
Issuer
N
3593
06/30/2025
Cash
Y
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
06/30/2025
11/22/2024
/s/ William Garrett Nichols