<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001883986</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0002023658</issuerCik>
            <issuerName>BICARA THERAPEUTICS INC.</issuerName>
            <secFileNumber>001-42271</secFileNumber>
            <issuerAddress>
                <ns2:street1>116 Huntington Ave</ns2:street1>
                <ns2:city>Boston</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02116</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>617-468-4219</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>LARA S. MEISNER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>31658</noOfUnitsSold>
            <aggregateMarketValue>343172.72</aggregateMarketValue>
            <noOfUnitsOutstanding>54536218</noOfUnitsOutstanding>
            <approxSaleDate>06/16/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/16/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>31658</amountOfSecuritiesAcquired>
            <paymentDate>06/16/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>06/16/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/13/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Lara S Meisner</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001883986
XXXXXXXX
LIVE
0002023658
BICARA THERAPEUTICS INC.
001-42271
116 Huntington Ave
Boston
MA
02116
617-468-4219
LARA S. MEISNER
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
31658
343172.72
54536218
06/16/2025
NASDAQ
Common
06/16/2025
Exercise of Stock Options
Issuer
N
31658
06/16/2025
Cash
Y
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
06/16/2025
11/13/2024
/s/ Lara S Meisner