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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>001-37478</secFileNumber>
            <issuerAddress>
                <ns2:street1>13011 MCCALLEN PASS</ns2:street1>
                <ns2:street2>Building A Suite 100</ns2:street2>
                <ns2:city>AUSTIN</ns2:city>
                <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                <ns2:zipCode>78753</ns2:zipCode>
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            <issuerContactPhone>650-980-9190</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MICHAEL BURKES BROPHY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>1378</noOfUnitsSold>
            <aggregateMarketValue>128098.88</aggregateMarketValue>
            <noOfUnitsOutstanding>120757877</noOfUnitsOutstanding>
            <approxSaleDate>04/02/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/27/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1378</amountOfSecuritiesAcquired>
            <paymentDate>03/27/2020</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
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                    <ns2:street1>13011 MCCALLEN PASS</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>AUSTIN</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/06/2024</saleDate>
            <amountOfSecuritiesSold>34029</amountOfSecuritiesSold>
            <grossProceeds>2383126.90</grossProceeds>
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            <sellerDetails>
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                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>AUSTIN</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
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                    <ns2:city>AUSTIN</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/24/2024</saleDate>
            <amountOfSecuritiesSold>944</amountOfSecuritiesSold>
            <grossProceeds>63248.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for MICHAEL BURKES BROPHY</name>
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                    <ns2:street1>13011 MCCALLEN PASS</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>AUSTIN</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
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            <grossProceeds>124569.85</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/02/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/14/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Michael Burkes Brophy</signature>
        </noticeSignature>
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144
0001697362
XXXXXXXX
LIVE
0001604821
NATERA INC
001-37478
13011 MCCALLEN PASS
Building A Suite 100
AUSTIN
TX
78753
650-980-9190
MICHAEL BURKES BROPHY
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
1378
128098.88
120757877
04/02/2024
NASDAQ
Common
03/27/2020
Restricted Stock Units
Issuer
N
1378
03/27/2020
N/A
N
10b5-1 Sales Plan for MICHAEL BURKES BROPHY
13011 MCCALLEN PASS
Building A Suite 100
AUSTIN
TX
78753
Common
02/06/2024
34029
2383126.90
10b5-1 Sales Plan for MICHAEL BURKES BROPHY
13011 MCCALLEN PASS
Building A Suite 100
AUSTIN
TX
78753
Common
02/01/2024
22281
1509080.99
10b5-1 Sales Plan for MICHAEL BURKES BROPHY
13011 MCCALLEN PASS
Building A Suite 100
AUSTIN
TX
78753
Common
01/24/2024
944
63248.00
10b5-1 Sales Plan for MICHAEL BURKES BROPHY
13011 MCCALLEN PASS
Building A Suite 100
AUSTIN
TX
78753
Common
01/23/2024
1896
124569.85
04/02/2024
03/14/2023
/s/ Michael Burkes Brophy