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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001124524</issuerCik>
            <issuerName>CRYOPORT, INC.</issuerName>
            <secFileNumber>001-34632</secFileNumber>
            <issuerAddress>
                <ns2:street1>112 Westwood Place, Suite 350</ns2:street1>
                <ns2:city>Brentwood</ns2:city>
                <ns2:stateOrCountry>TN</ns2:stateOrCountry>
                <ns2:zipCode>37027</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(949) 470-2300</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JERRELL SHELTON</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>26875</noOfUnitsSold>
            <aggregateMarketValue>383404.13</aggregateMarketValue>
            <noOfUnitsOutstanding>48879018</noOfUnitsOutstanding>
            <approxSaleDate>09/01/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/01/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>26875</amountOfSecuritiesAcquired>
            <paymentDate>09/01/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>09/01/2023</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Jerrell Wilson Shelton</signature>
        </noticeSignature>
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144
0001283212
XXXXXXXX
LIVE
0001124524
CRYOPORT, INC.
001-34632
112 Westwood Place, Suite 350
Brentwood
TN
37027
(949) 470-2300
JERRELL SHELTON
Officer
Director
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
26875
383404.13
48879018
09/01/2023
NASDAQ
Common
09/01/2023
Stock Option Exercise
Issuer
N
26875
09/01/2023
Cash
Y
09/01/2023
/s/ Jerrell Wilson Shelton