<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001462808</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001628171</issuerCik>
            <issuerName>REVOLUTION MEDICINES INC</issuerName>
            <secFileNumber>001-39219</secFileNumber>
            <issuerAddress>
                <ns2:street1>700 Saginaw Drive </ns2:street1>
                <ns2:city>Redwood City</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94063</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6504816801</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEPHEN M. KELSEY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>16666</noOfUnitsSold>
            <aggregateMarketValue>841299.68</aggregateMarketValue>
            <noOfUnitsOutstanding>167038943</noOfUnitsOutstanding>
            <approxSaleDate>10/14/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>10/14/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>16666</amountOfSecuritiesAcquired>
            <paymentDate>10/14/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for STEPHEN M. KELSEY</name>
                <address>
                    <ns2:street1>700 Saginaw Drive </ns2:street1>
                    <ns2:city>Redwood City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>09/13/2024</saleDate>
            <amountOfSecuritiesSold>16667</amountOfSecuritiesSold>
            <grossProceeds>722087.77</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for STEPHEN M. KELSEY</name>
                <address>
                    <ns2:street1>700 Saginaw Drive </ns2:street1>
                    <ns2:city>Redwood City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>08/13/2024</saleDate>
            <amountOfSecuritiesSold>16667</amountOfSecuritiesSold>
            <grossProceeds>716389.33</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for STEPHEN M. KELSEY</name>
                <address>
                    <ns2:street1>700 Saginaw Drive </ns2:street1>
                    <ns2:city>Redwood City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>07/15/2024</saleDate>
            <amountOfSecuritiesSold>16667</amountOfSecuritiesSold>
            <grossProceeds>774517.16</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>Sales that were executed on October 14, 2024 are being reported on this Form 144 filed on October 15, 2024 given the EDGAR system was not accepting filings on October 14, 2024 in observance of the federal holiday. </remarks>
        <noticeSignature>
            <noticeDate>10/14/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/14/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Stephen M Kelsey</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5706}]
144
0001462808
XXXXXXXX
LIVE
0001628171
REVOLUTION MEDICINES INC
001-39219
700 Saginaw Drive
Redwood City
CA
94063
6504816801
STEPHEN M. KELSEY
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
16666
841299.68
167038943
10/14/2024
NASDAQ
Common
10/14/2024
Exercise of Stock Options
Issuer
N
16666
10/14/2024
Cash
N
10b5-1 Sales for STEPHEN M. KELSEY
700 Saginaw Drive
Redwood City
CA
94063
COMMON
09/13/2024
16667
722087.77
10b5-1 Sales for STEPHEN M. KELSEY
700 Saginaw Drive
Redwood City
CA
94063
COMMON
08/13/2024
16667
716389.33
10b5-1 Sales for STEPHEN M. KELSEY
700 Saginaw Drive
Redwood City
CA
94063
COMMON
07/15/2024
16667
774517.16
Sales that were executed on October 14, 2024 are being reported on this Form 144 filed on October 15, 2024 given the EDGAR system was not accepting filings on October 14, 2024 in observance of the federal holiday.
10/14/2024
03/14/2024
/s/ Stephen M Kelsey