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            <filer>
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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>001-40445</secFileNumber>
            <issuerAddress>
                <ns2:street1>1 Ashley Road</ns2:street1>
                <ns2:city>Altrincham</ns2:city>
                <ns2:stateOrCountry>X0</ns2:stateOrCountry>
                <ns2:zipCode>WA14 2DT</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>44 203 9206789</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ANTOINE YVER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer> Director</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>6700</noOfUnitsSold>
            <aggregateMarketValue>24729.70</aggregateMarketValue>
            <noOfUnitsOutstanding>94961169</noOfUnitsOutstanding>
            <approxSaleDate>04/03/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>04/03/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6700</amountOfSecuritiesAcquired>
            <paymentDate>04/03/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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            <sellerDetails>
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                <address>
                    <ns2:street1>1 Ashley Road</ns2:street1>
                    <ns2:city>Altrincham</ns2:city>
                    <ns2:stateOrCountry>X0</ns2:stateOrCountry>
                    <ns2:zipCode>WA14 2DT</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/01/2023</saleDate>
            <amountOfSecuritiesSold>7000</amountOfSecuritiesSold>
            <grossProceeds>23403.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
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                <address>
                    <ns2:street1>1 Ashley Road</ns2:street1>
                    <ns2:city>Altrincham</ns2:city>
                    <ns2:stateOrCountry>X0</ns2:stateOrCountry>
                    <ns2:zipCode>WA14 2DT</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/01/2023</saleDate>
            <amountOfSecuritiesSold>7700</amountOfSecuritiesSold>
            <grossProceeds>28655.00</grossProceeds>
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                    <ns2:stateOrCountry>X0</ns2:stateOrCountry>
                    <ns2:zipCode>WA14 2DT</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/04/2023</saleDate>
            <amountOfSecuritiesSold>6970</amountOfSecuritiesSold>
            <grossProceeds>21641.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/03/2023</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Antoine Yver</signature>
        </noticeSignature>
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144
0001861878
XXXXXXXX
LIVE
0001847903
CENTESSA PHARMACEUTICALS PLC
001-40445
1 Ashley Road
Altrincham
X0
WA14 2DT
44 203 9206789
ANTOINE YVER
Officer
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
6700
24729.70
94961169
04/03/2023
NASDAQ
Common
04/03/2023
Restricted Stock Units
Issuer
N
6700
04/03/2023
Cash
N
Antoine Yver
1 Ashley Road
Altrincham
X0
WA14 2DT
Common
03/01/2023
7000
23403.00
Antoine Yver
1 Ashley Road
Altrincham
X0
WA14 2DT
Common
02/01/2023
7700
28655.00
Antoine Yver
1 Ashley Road
Altrincham
X0
WA14 2DT
Common
01/04/2023
6970
21641.00
04/03/2023
/s/ Antoine Yver