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            <issuerCik>0001819133</issuerCik>
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            <secFileNumber>001-39485</secFileNumber>
            <issuerAddress>
                <ns2:street1>201 BROOKLINE AVENUE, SUITE 901</ns2:street1>
                <ns2:city>BOSTON</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02215</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8573204900</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>LESLEY A CALHOUN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>5000</noOfUnitsSold>
            <aggregateMarketValue>35600.00</aggregateMarketValue>
            <noOfUnitsOutstanding>106846262</noOfUnitsOutstanding>
            <approxSaleDate>06/05/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/05/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
            <paymentDate>06/05/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/05/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/06/2023</planAdoptionDate>
            </planAdoptionDates>
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144
0001730866
XXXXXXXX
LIVE
0001819133
TANGO THERAPEUTICS INC
001-39485
201 BROOKLINE AVENUE, SUITE 901
BOSTON
MA
02215
8573204900
LESLEY A CALHOUN
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
5000
35600.00
106846262
06/05/2024
NASDAQ
Common
06/05/2024
Restricted Stock Units
Issuer
N
5000
06/05/2024
N/A
Y
06/05/2024
11/06/2023
/s/ Lesley Ann Calhoun