<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001047058</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001039065</issuerCik>
            <issuerName>OSI SYSTEMS INC</issuerName>
            <secFileNumber>000-23125</secFileNumber>
            <issuerAddress>
                <ns2:street1>12525 Chadron Avenue</ns2:street1>
                <ns2:city>Hawthorne</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>90250</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>310-978-0516</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CHOPRA 2012 IRREVOCABLE TRUST</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>spouse </relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>5000</noOfUnitsSold>
            <aggregateMarketValue>767325.50</aggregateMarketValue>
            <noOfUnitsOutstanding>16710749</noOfUnitsOutstanding>
            <approxSaleDate>11/11/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/27/2012</acquiredDate>
            <natureOfAcquisitionTransaction>Gift from Affiliate</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Deepak Chopra</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>Y</isGiftTransaction>
            <donarAcquiredDate>01/01/1989</donarAcquiredDate>
            <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
            <natureOfPayment>NA</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings on November 11, 2024 in observance of the federal holiday.</remarks>
        <noticeSignature>
            <noticeDate>11/11/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Nandini Chopra, trustee</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3483}]
144
0001047058
XXXXXXXX
LIVE
0001039065
OSI SYSTEMS INC
000-23125
12525 Chadron Avenue
Hawthorne
CA
90250
310-978-0516
CHOPRA 2012 IRREVOCABLE TRUST
spouse
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
5000
767325.50
16710749
11/11/2024
NASDAQ
Common
12/27/2012
Gift from Affiliate
Deepak Chopra
Y
01/01/1989
5000
NA
Y
Sales that were executed on November 11, 2024 are being reported on this Form 144 filed on November 12, 2024 given the EDGAR system was not accepting filings on November 11, 2024 in observance of the federal holiday.
11/11/2024
/s/ Nandini Chopra, trustee