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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001657719</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001492422</issuerCik>
            <issuerName>APELLIS PHARMACEUTICALS, INC</issuerName>
            <secFileNumber>001-38276</secFileNumber>
            <issuerAddress>
                <ns2:street1>100 FIFTH AVENUE</ns2:street1>
                <ns2:city>WALTHAM</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02451</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>617-977-5700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>DAVID OSBORNE WATSON</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>5569</noOfUnitsSold>
            <aggregateMarketValue>139789.14</aggregateMarketValue>
            <noOfUnitsOutstanding>125515813</noOfUnitsOutstanding>
            <approxSaleDate>03/05/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/10/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1125</amountOfSecuritiesAcquired>
            <paymentDate>02/10/2021</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/22/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>397</amountOfSecuritiesAcquired>
            <paymentDate>12/22/2021</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/22/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2944</amountOfSecuritiesAcquired>
            <paymentDate>12/22/2021</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/10/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1103</amountOfSecuritiesAcquired>
            <paymentDate>02/10/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>DAVID OSBORNE WATSON</name>
                <address>
                    <ns2:street1>100 FIFTH AVENUE</ns2:street1>
                    <ns2:city>WALTHAM</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/11/2024</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>171175.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>03/05/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ David Osborne Watson</signature>
        </noticeSignature>
    </formData>
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144
0001657719
XXXXXXXX
LIVE
0001492422
APELLIS PHARMACEUTICALS, INC
001-38276
100 FIFTH AVENUE
WALTHAM
MA
02451
617-977-5700
DAVID OSBORNE WATSON
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
5569
139789.14
125515813
03/05/2025
NASDAQ
Common
02/10/2021
Restricted stock vesting under a registered plan
Issuer
N
1125
02/10/2021
Not Applicable
Common
12/22/2021
Exercise of options under a registered plan
Issuer
N
397
12/22/2021
Not Applicable
Common
12/22/2021
Exercise of options under a registered plan
Issuer
N
2944
12/22/2021
Not Applicable
Common
02/10/2022
Restricted stock vesting under a registered plan
Issuer
N
1103
02/10/2022
Not Applicable
N
DAVID OSBORNE WATSON
100 FIFTH AVENUE
WALTHAM
MA
02451
Common
12/11/2024
5000
171175.00
03/05/2025
/s/ David Osborne Watson