<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001665881</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001287865</issuerCik>
      <issuerName>MEDICAL PROPERTIES TRUST INC</issuerName>
      <secFileNumber>001-32559</secFileNumber>
      <issuerAddress>
        <com:street1>1000 URBAN CENTER DRIVE</com:street1>
        <com:street2>SUITE 501</com:street2>
        <com:city>BIRMINGHAM</com:city>
        <com:stateOrCountry>AL</com:stateOrCountry>
        <com:zipCode>35242</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>205-969-3755</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Hanna James Kevin</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Wells Fargo Clearing Services</name>
        <address>
          <com:street1>One North Jefferson Avenue</com:street1>
          <com:city>St. Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63103</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>11641</noOfUnitsSold>
      <aggregateMarketValue>42540.77</aggregateMarketValue>
      <noOfUnitsOutstanding>600400000</noOfUnitsOutstanding>
      <approxSaleDate>12/26/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/01/2019</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11641</amountOfSecuritiesAcquired>
      <paymentDate>01/01/2019</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>The sale was made in connection with the reporting persons year end tax planning for 2024 The reporting person intends but is not required to repurchase an equal number of shares, subject to compliance with laws and company policies, as well as then market conditions</remarks>
    <noticeSignature>
      <noticeDate>12/26/2024</noticeDate>
      <signature>James Kevin Hanna</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
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144
0001665881
XXXXXXXX
LIVE
0001287865
MEDICAL PROPERTIES TRUST INC
001-32559
1000 URBAN CENTER DRIVE
SUITE 501
BIRMINGHAM
AL
35242
205-969-3755
Hanna James Kevin
Officer
Common
Wells Fargo Clearing Services
One North Jefferson Avenue
St. Louis
MO
63103
11641
42540.77
600400000
12/26/2024
NYSE
Common
01/01/2019
Compensation
Issuer
N
11641
01/01/2019
N/A
Y
The sale was made in connection with the reporting persons year end tax planning for 2024 The reporting person intends but is not required to repurchase an equal number of shares, subject to compliance with laws and company policies, as well as then market conditions
12/26/2024
James Kevin Hanna