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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001185035</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001798749</issuerCik>
            <issuerName>AEROVATE THERAPEUTICS INC.</issuerName>
            <secFileNumber>001-40544</secFileNumber>
            <issuerAddress>
                <ns2:street1>930 Winter Street, Suite M-500</ns2:street1>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02451</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(617) 443-2400</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>TIMOTHY NOYES</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>4522</noOfUnitsSold>
            <aggregateMarketValue>81895.68</aggregateMarketValue>
            <noOfUnitsOutstanding>27601098</noOfUnitsOutstanding>
            <approxSaleDate>07/17/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>07/17/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>4522</amountOfSecuritiesAcquired>
            <paymentDate>07/17/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>TIMOTHY NOYES</name>
                <address>
                    <ns2:street1>930 Winter Street, Suite M-500</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/03/2023</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>180000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>TIMOTHY NOYES</name>
                <address>
                    <ns2:street1>930 Winter Street, Suite M-500</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/02/2023</saleDate>
            <amountOfSecuritiesSold>693</amountOfSecuritiesSold>
            <grossProceeds>14656.95</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>TIMOTHY NOYES</name>
                <address>
                    <ns2:street1>930 Winter Street, Suite M-500</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/01/2023</saleDate>
            <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
            <grossProceeds>309087.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>07/17/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/24/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>Timothy Paul Noyes</signature>
        </noticeSignature>
    </formData>
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144
0001185035
XXXXXXXX
LIVE
0001798749
AEROVATE THERAPEUTICS INC.
001-40544
930 Winter Street, Suite M-500
Waltham
MA
02451
(617) 443-2400
TIMOTHY NOYES
Officer
Director
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
4522
81895.68
27601098
07/17/2023
NASD
COMMON
07/17/2023
Stock Option Exercise
ISSUER
N
4522
07/17/2023
Cash
N
TIMOTHY NOYES
930 Winter Street, Suite M-500
Waltham
MA
02451
Common
07/03/2023
10000
180000.00
TIMOTHY NOYES
930 Winter Street, Suite M-500
Waltham
MA
02451
Common
05/02/2023
693
14656.95
TIMOTHY NOYES
930 Winter Street, Suite M-500
Waltham
MA
02451
Common
05/01/2023
15000
309087.00
07/17/2023
02/24/2023
Timothy Paul Noyes