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      <issuerCik>0001665918</issuerCik>
      <issuerName>US Foods Holding Corp.</issuerName>
      <secFileNumber>001-37786</secFileNumber>
      <issuerAddress>
        <com:street1>9399 W. HIGGINS RD.</com:street1>
        <com:street2>SUITE 100</com:street2>
        <com:city>ROSEMONT</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60018</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>8477208000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Gupta Sunil</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
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    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>100 Summer Street</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>5756</noOfUnitsSold>
      <aggregateMarketValue>226164.18</aggregateMarketValue>
      <noOfUnitsOutstanding>224320466</noOfUnitsOutstanding>
      <approxSaleDate>02/22/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/04/2019</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
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      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>994</amountOfSecuritiesAcquired>
      <paymentDate>05/04/2019</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
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    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
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      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
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      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>924</amountOfSecuritiesAcquired>
      <paymentDate>05/01/2020</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
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    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
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      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
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      <paymentDate>05/04/2020</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
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    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
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      <paymentDate>05/01/2021</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
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    <securitiesToBeSold>
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      <amountOfSecuritiesAcquired>995</amountOfSecuritiesAcquired>
      <paymentDate>05/04/2021</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/01/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>925</amountOfSecuritiesAcquired>
      <paymentDate>05/01/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>02/22/2023</noticeDate>
      <signature>/s/ Lisa Gerard, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Sunil Gupta</signature>
    </noticeSignature>
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144
0001733497
XXXXXXXX
LIVE
0001665918
US Foods Holding Corp.
001-37786
9399 W. HIGGINS RD.
SUITE 100
ROSEMONT
IL
60018
8477208000
Gupta Sunil
Director
Common
Fidelity Brokerage Services LLC
100 Summer Street
Boston
MA
02110
5756
226164.18
224320466
02/22/2023
NYSE
Common
05/04/2019
Restricted Stock Vesting
Issuer
N
994
05/04/2019
Compensation
Common
05/01/2020
Restricted Stock Vesting
Issuer
N
924
05/01/2020
Compensation
Common
05/04/2020
Restricted Stock Vesting
Issuer
N
994
05/04/2020
Compensation
Common
05/01/2021
Restricted Stock Vesting
Issuer
N
924
05/01/2021
Compensation
Common
05/04/2021
Restricted Stock Vesting
Issuer
N
995
05/04/2021
Compensation
Common
05/01/2022
Restricted Stock Vesting
Issuer
N
925
05/01/2022
Compensation
Y
02/22/2023
/s/ Lisa Gerard, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Sunil Gupta