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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001938943</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001410384</issuerCik>
      <issuerName>Q2 Holdings, Inc.</issuerName>
      <secFileNumber>001-36350</secFileNumber>
      <issuerAddress>
        <com:street1>10355 PECAN PARK BOULEVARD</com:street1>
        <com:city>Austin</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>78729</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>1-833-444-3469</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kerr Michael S</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Etrade Financial Corporation</name>
        <address>
          <com:street1>3 Edison Dr</com:street1>
          <com:city>Alpharetta</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30005</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>635</noOfUnitsSold>
      <aggregateMarketValue>21399.50</aggregateMarketValue>
      <noOfUnitsOutstanding>43254</noOfUnitsOutstanding>
      <approxSaleDate>09/11/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Stock</securitiesClassTitle>
      <acquiredDate>09/11/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>635</amountOfSecuritiesAcquired>
      <paymentDate>09/11/2023</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>09/11/2023</noticeDate>
      <signature>/s/ Scott Kerr</signature>
    </noticeSignature>
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144
0001938943
XXXXXXXX
LIVE
0001410384
Q2 Holdings, Inc.
001-36350
10355 PECAN PARK BOULEVARD
Austin
TX
78729
1-833-444-3469
Kerr Michael S
Officer
Stock
Etrade Financial Corporation
3 Edison Dr
Alpharetta
GA
30005
635
21399.50
43254
09/11/2023
NYSE
Stock
09/11/2023
Restricted Stock
Issuer
N
635
09/11/2023
N/A
Y
09/11/2023
/s/ Scott Kerr