<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001213041</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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    <formData>
        <issuerInfo>
            <issuerCik>0001437402</issuerCik>
            <issuerName>ARDELYX, INC.</issuerName>
            <secFileNumber>001-36485</secFileNumber>
            <issuerAddress>
                <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02451</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 745-1700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ELIZABETH GRAMMER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>45000</noOfUnitsSold>
            <aggregateMarketValue>405000.00</aggregateMarketValue>
            <noOfUnitsOutstanding>233976572</noOfUnitsOutstanding>
            <approxSaleDate>05/03/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>06/01/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>45000</amountOfSecuritiesAcquired>
            <paymentDate>06/01/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ELIZABETH GRAMMER</name>
                <address>
                    <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/20/2024</saleDate>
            <amountOfSecuritiesSold>86000</amountOfSecuritiesSold>
            <grossProceeds>664977.80</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ELIZABETH GRAMMER</name>
                <address>
                    <ns2:street1>400 Fifth Avenue, Suite 210</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/20/2024</saleDate>
            <amountOfSecuritiesSold>4432</amountOfSecuritiesSold>
            <grossProceeds>38738.29</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/03/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/20/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Elizabeth Anne Grammer</signature>
        </noticeSignature>
    </formData>
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144
0001213041
XXXXXXXX
LIVE
0001437402
ARDELYX, INC.
001-36485
400 Fifth Avenue, Suite 210
Waltham
MA
02451
(510) 745-1700
ELIZABETH GRAMMER
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
45000
405000.00
233976572
05/03/2024
NASDAQ
COMMON
06/01/2022
Restricted Stock
ISSUER
N
45000
06/01/2022
Not Applicable
N
ELIZABETH GRAMMER
400 Fifth Avenue, Suite 210
Waltham
MA
02451
Common
03/20/2024
86000
664977.80
ELIZABETH GRAMMER
400 Fifth Avenue, Suite 210
Waltham
MA
02451
Common
02/20/2024
4432
38738.29
05/03/2024
12/20/2023
/s/ Elizabeth Anne Grammer