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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>001-35406</secFileNumber>
            <issuerAddress>
                <ns2:street1>5200 Illumina Way</ns2:street1>
                <ns2:city>SAN DIEGO</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92122</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>858-202-4500</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PATRICIA L LECKMAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>1756</noOfUnitsSold>
            <aggregateMarketValue>175600.00</aggregateMarketValue>
            <noOfUnitsOutstanding>158400000</noOfUnitsOutstanding>
            <approxSaleDate>02/18/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/05/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
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            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>607</amountOfSecuritiesAcquired>
            <paymentDate>11/05/2022</paymentDate>
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            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>877</amountOfSecuritiesAcquired>
            <paymentDate>11/05/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>04/05/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
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            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>272</amountOfSecuritiesAcquired>
            <paymentDate>04/05/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>02/18/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/13/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Patricia Leigh Leckman</signature>
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144
0002015062
XXXXXXXX
LIVE
0001110803
ILLUMINA, INC.
001-35406
5200 Illumina Way
SAN DIEGO
CA
92122
858-202-4500
PATRICIA L LECKMAN
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
1756
175600.00
158400000
02/18/2025
NASDAQ
Common
11/05/2022
Restricted Stock
ISSUER
N
607
11/05/2022
Not Applicable
Common
11/05/2023
Restricted Stock
ISSUER
N
877
11/05/2023
Not Applicable
Common
04/05/2023
Restricted Stock
ISSUER
N
272
04/05/2023
Not Applicable
Y
02/18/2025
11/13/2024
/s/ Patricia Leigh Leckman