<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001246842</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001628171</issuerCik>
            <issuerName>REVOLUTION MEDICINES INC</issuerName>
            <secFileNumber>001-39219</secFileNumber>
            <issuerAddress>
                <ns2:street1>700 Saginaw Drive </ns2:street1>
                <ns2:city>Redwood City</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94063</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6504816801</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MARK A GOLDSMITH </nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>60000</noOfUnitsSold>
            <aggregateMarketValue>3210000.00</aggregateMarketValue>
            <noOfUnitsOutstanding>167038943</noOfUnitsOutstanding>
            <approxSaleDate>11/01/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/01/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>60000</amountOfSecuritiesAcquired>
            <paymentDate>11/01/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MARK A GOLDSMITH </name>
                <address>
                    <ns2:street1>700 Saginaw Drive </ns2:street1>
                    <ns2:city>Redwood City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/11/2024</saleDate>
            <amountOfSecuritiesSold>30000</amountOfSecuritiesSold>
            <grossProceeds>1510773.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for MARK A GOLDSMITH </name>
                <address>
                    <ns2:street1>700 Saginaw Drive </ns2:street1>
                    <ns2:city>Redwood City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/01/2024</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>449322.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>11/01/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/01/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Mark A Goldsmith</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5032}]
144
0001246842
XXXXXXXX
LIVE
0001628171
REVOLUTION MEDICINES INC
001-39219
700 Saginaw Drive
Redwood City
CA
94063
6504816801
MARK A GOLDSMITH
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
60000
3210000.00
167038943
11/01/2024
NASDAQ
Common
11/01/2024
Exercise of Stock Options
Issuer
N
60000
11/01/2024
Cash
N
10b5-1 Sales for MARK A GOLDSMITH
700 Saginaw Drive
Redwood City
CA
94063
Common
10/11/2024
30000
1510773.00
10b5-1 Sales for MARK A GOLDSMITH
700 Saginaw Drive
Redwood City
CA
94063
Common
10/01/2024
10000
449322.00
The securities to be sold will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment will be the dates of exercise/sale.
11/01/2024
12/01/2023
/s/ Mark A Goldsmith