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                    <cik>0001821102</cik>
                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001802665</issuerCik>
            <issuerName>HARMONY BIOSCIENCES HLDGS INC</issuerName>
            <secFileNumber>001-39450</secFileNumber>
            <issuerAddress>
                <ns2:street1>630 W Germantown Pike, Suite 215</ns2:street1>
                <ns2:city>Plymouth Meeting</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19462</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>4845399800</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JEFFREY G DIERKS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>47162</noOfUnitsSold>
            <aggregateMarketValue>1596905.32</aggregateMarketValue>
            <noOfUnitsOutstanding>57031297</noOfUnitsOutstanding>
            <approxSaleDate>01/13/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/13/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>47162</amountOfSecuritiesAcquired>
            <paymentDate>01/13/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JEFFREY G DIERKS</name>
                <address>
                    <ns2:street1>630 W Germantown Pike, Suite 215</ns2:street1>
                    <ns2:city>Plymouth Meeting</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19462</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/29/2024</saleDate>
            <amountOfSecuritiesSold>21496</amountOfSecuritiesSold>
            <grossProceeds>870018.44</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>01/13/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/27/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jeffrey G. Dierks</signature>
        </noticeSignature>
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144
0001821102
XXXXXXXX
LIVE
0001802665
HARMONY BIOSCIENCES HLDGS INC
001-39450
630 W Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
4845399800
JEFFREY G DIERKS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
47162
1596905.32
57031297
01/13/2025
NASDAQ
Common
01/13/2025
Exercise of Stock Options
Issuer
N
47162
01/13/2025
Cash
N
10b5-1 Sales for JEFFREY G DIERKS
630 W Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
Common
10/29/2024
21496
870018.44
The securities to be sold will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment will be the dates of exercise/sale.
01/13/2025
08/27/2024
/s/ Jeffrey G. Dierks