<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001492125</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001048695</issuerCik>
            <issuerName>F5, INC.</issuerName>
            <secFileNumber>000-26041</secFileNumber>
            <issuerAddress>
                <ns2:street1>801 5TH AVENUE</ns2:street1>
                <ns2:city>Seattle</ns2:city>
                <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                <ns2:zipCode>98104</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>206-272-5555</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>FRANK PELZER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>500</noOfUnitsSold>
            <aggregateMarketValue>86870.00</aggregateMarketValue>
            <noOfUnitsOutstanding>58611430</noOfUnitsOutstanding>
            <approxSaleDate>05/20/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>11/01/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>500</amountOfSecuritiesAcquired>
            <paymentDate>11/01/2021</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FRANK PELZER</name>
                <address>
                    <ns2:street1>801 5TH AVENUE</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/22/2024</saleDate>
            <amountOfSecuritiesSold>500</amountOfSecuritiesSold>
            <grossProceeds>89405.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>FRANK PELZER</name>
                <address>
                    <ns2:street1>801 5TH AVENUE</ns2:street1>
                    <ns2:city>Seattle</ns2:city>
                    <ns2:stateOrCountry>WA</ns2:stateOrCountry>
                    <ns2:zipCode>98104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/20/2024</saleDate>
            <amountOfSecuritiesSold>500</amountOfSecuritiesSold>
            <grossProceeds>94560.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/20/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/11/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Francis J. Pelzer</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001492125
XXXXXXXX
LIVE
0001048695
F5, INC.
000-26041
801 5TH AVENUE
Seattle
WA
98104
206-272-5555
FRANK PELZER
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
500
86870.00
58611430
05/20/2024
NASDAQ
COMMON
11/01/2021
Restricted Stock
ISSUER
N
500
11/01/2021
Not Applicable
N
FRANK PELZER
801 5TH AVENUE
Seattle
WA
98104
Common
04/22/2024
500
89405.00
FRANK PELZER
801 5TH AVENUE
Seattle
WA
98104
Common
03/20/2024
500
94560.00
05/20/2024
08/11/2023
/s/ Francis J. Pelzer