<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001181556</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001599901</issuerCik>
            <issuerName>AVIDITY BIOSCIENCES INC</issuerName>
            <secFileNumber>001-39321</secFileNumber>
            <issuerAddress>
                <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92121</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8584017900</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ARTHUR A LEVIN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>20000</noOfUnitsSold>
            <aggregateMarketValue>766600.00</aggregateMarketValue>
            <noOfUnitsOutstanding>95636748</noOfUnitsOutstanding>
            <approxSaleDate>06/20/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/20/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>20000</amountOfSecuritiesAcquired>
            <paymentDate>06/20/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for A A LEVIN &amp; M BUTLER CO-TTEEBUTLER-LEVIN REVOCABLE TRUST U/ADTD 05/27/2003</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>60000</amountOfSecuritiesSold>
            <grossProceeds>2404782.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for A A LEVIN &amp; M BUTLER CO-TTEEBUTLER-LEVIN REVOCABLE TRUST U/ADTD 05/27/2003</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>06/12/2024</saleDate>
            <amountOfSecuritiesSold>40000</amountOfSecuritiesSold>
            <grossProceeds>1402628.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ARTHUR A LEVIN</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/20/2024</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>149481.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ARTHUR A LEVIN</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/19/2024</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>114123.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for A A LEVIN &amp; M BUTLER CO-TTEEBUTLER-LEVIN REVOCABLE TRUST U/ADTD 05/27/2003</name>
                <address>
                    <ns2:street1>10578 Science Center Drive, Suite 125</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>04/03/2024</saleDate>
            <amountOfSecuritiesSold>20000</amountOfSecuritiesSold>
            <grossProceeds>542214.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months.&#13;
The date of acquisition and payment was and will be the date of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>06/20/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/26/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Arthur A Levin</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 7395}]
144
0001181556
XXXXXXXX
LIVE
0001599901
AVIDITY BIOSCIENCES INC
001-39321
10578 Science Center Drive, Suite 125
San Diego
CA
92121
8584017900
ARTHUR A LEVIN
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
20000
766600.00
95636748
06/20/2024
NASDAQ
Common
06/20/2024
Exercise of Stock Options
Issuer
N
20000
06/20/2024
Cash
N
10b5-1 Sales for A A LEVIN & M BUTLER CO-TTEEBUTLER-LEVIN REVOCABLE TRUST U/ADTD 05/27/2003
10578 Science Center Drive, Suite 125
San Diego
CA
92121
COMMON
06/13/2024
60000
2404782.00
10b5-1 Sales for A A LEVIN & M BUTLER CO-TTEEBUTLER-LEVIN REVOCABLE TRUST U/ADTD 05/27/2003
10578 Science Center Drive, Suite 125
San Diego
CA
92121
COMMON
06/12/2024
40000
1402628.00
10b5-1 Sales for ARTHUR A LEVIN
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
05/20/2024
5000
149481.00
10b5-1 Sales for ARTHUR A LEVIN
10578 Science Center Drive, Suite 125
San Diego
CA
92121
Common
04/19/2024
5000
114123.00
10b5-1 Sales for A A LEVIN & M BUTLER CO-TTEEBUTLER-LEVIN REVOCABLE TRUST U/ADTD 05/27/2003
10578 Science Center Drive, Suite 125
San Diego
CA
92121
COMMON
04/03/2024
20000
542214.00
The securities to be sold were and will be received upon the exercise of stock options over the next three months.
The date of acquisition and payment was and will be the date of exercise/sale.
06/20/2024
05/26/2023
/s/ Arthur A Levin