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      <issuerCik>0001062822</issuerCik>
      <issuerName>LEXICON PHARMACEUTICALS, INC.</issuerName>
      <secFileNumber>000-30111</secFileNumber>
      <issuerAddress>
        <com:street1>2445 TECHNOLOGY FOREST BLVD.</com:street1>
        <com:street2>SUITE 1100</com:street2>
        <com:city>THE WOODLANDS</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>77381</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>2818633000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Seth Kiernan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Former Affiliate</relationshipToIssuer>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>19000</noOfUnitsSold>
      <aggregateMarketValue>43890.00</aggregateMarketValue>
      <noOfUnitsOutstanding>189561819</noOfUnitsOutstanding>
      <approxSaleDate>07/12/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/28/2002</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Lexicon Pharmaceuticals, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>19000</amountOfSecuritiesAcquired>
      <paymentDate>02/28/2002</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>07/12/2023</noticeDate>
      <signature>Kiernan Seth</signature>
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144
0001890439
XXXXXXXX
LIVE
0001062822
LEXICON PHARMACEUTICALS, INC.
000-30111
2445 TECHNOLOGY FOREST BLVD.
SUITE 1100
THE WOODLANDS
TX
77381
2818633000
Seth Kiernan
Former Affiliate
Common
Charles Schwab & Co., Inc.
3000 Schwab Way
Westlake
TX
76262
19000
43890.00
189561819
07/12/2023
NASDAQ
Common
02/28/2002
Restricted Stock Lapse
Lexicon Pharmaceuticals, Inc.
N
19000
02/28/2002
Equity Compensation
Y
07/12/2023
Kiernan Seth