<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001185829</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001710072</issuerCik>
            <issuerName>EDGEWISE THERAPEUTICS INC</issuerName>
            <secFileNumber>001-40236</secFileNumber>
            <issuerAddress>
                <ns2:street1>1715 38th Street</ns2:street1>
                <ns2:city>Boulder</ns2:city>
                <ns2:stateOrCountry>CO</ns2:stateOrCountry>
                <ns2:zipCode>80301</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>7202627002</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KEVIN KOCH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>51181</noOfUnitsSold>
            <aggregateMarketValue>1509839.50</aggregateMarketValue>
            <noOfUnitsOutstanding>94688517</noOfUnitsOutstanding>
            <approxSaleDate>02/05/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/05/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>51181</amountOfSecuritiesAcquired>
            <paymentDate>02/05/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>02/05/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/30/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Kevin Koch</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001185829
XXXXXXXX
LIVE
0001710072
EDGEWISE THERAPEUTICS INC
001-40236
1715 38th Street
Boulder
CO
80301
7202627002
KEVIN KOCH
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
51181
1509839.50
94688517
02/05/2025
NASDAQ
Common
02/05/2025
Exercise of Stock Options
Issuer
N
51181
02/05/2025
Cash
Y
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
02/05/2025
09/30/2024
/s/ Kevin Koch