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                <filerCredentials>
                    <cik>0001698149</cik>
                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001888886</issuerCik>
            <issuerName>STRUCTURE THERAPEUTICS USA INC.</issuerName>
            <secFileNumber>001-41608</secFileNumber>
            <issuerAddress>
                <ns2:street1>601 Gateway Blvd.</ns2:street1>
                <ns2:street2>Suite 900</ns2:street2>
                <ns2:city>South San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 457-1978</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>RAYMOND C STEVENS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>ADR</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>185000</noOfUnitsSold>
            <aggregateMarketValue>9767352.50</aggregateMarketValue>
            <noOfUnitsOutstanding>57045779</noOfUnitsOutstanding>
            <approxSaleDate>06/10/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>ADR</securitiesClassTitle>
            <acquiredDate>03/11/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Founder Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>185000</amountOfSecuritiesAcquired>
            <paymentDate>03/11/2021</paymentDate>
            <natureOfPayment>Compensation</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>Exercise of options, loan repayment and tax obligations.</remarks>
        <noticeSignature>
            <noticeDate>06/10/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Raymon Stevens</signature>
        </noticeSignature>
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144
0001698149
XXXXXXXX
LIVE
0001888886
STRUCTURE THERAPEUTICS USA INC.
001-41608
601 Gateway Blvd.
Suite 900
South San Francisco
CA
94080
(650) 457-1978
RAYMOND C STEVENS
Officer
ADR
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
185000
9767352.50
57045779
06/10/2024
NASDAQ
ADR
03/11/2021
Founder Stock
Issuer
N
185000
03/11/2021
Compensation
Y
Exercise of options, loan repayment and tax obligations.
06/10/2024
/s/ Raymon Stevens