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      <secFileNumber>001-37372</secFileNumber>
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        <com:street1>100 TECHNOLOGY CENTER DRIVE</com:street1>
        <com:city>STOUGHTON</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02072</com:zipCode>
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      <issuerContactPhone>781-713-3699</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Ciaffoni Joseph</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
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        <relationshipToIssuer>Director</relationshipToIssuer>
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          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
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      <aggregateMarketValue>698929.20</aggregateMarketValue>
      <noOfUnitsOutstanding>34594760</noOfUnitsOutstanding>
      <approxSaleDate>06/02/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/10/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>31272</amountOfSecuritiesAcquired>
      <paymentDate>02/10/2023</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
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        <name>Joseph J. Ciaffoni</name>
        <address>
          <com:street1>100 Technology Center Drive</com:street1>
          <com:city>Stoughton</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02072</com:zipCode>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/30/2023</saleDate>
      <amountOfSecuritiesSold>31271</amountOfSecuritiesSold>
      <grossProceeds>684906.77</grossProceeds>
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      <sellerDetails>
        <name>Joseph J. Ciaffoni</name>
        <address>
          <com:street1>100 Technology Center Drive</com:street1>
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          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02072</com:zipCode>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/31/2023</saleDate>
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          <com:zipCode>02072</com:zipCode>
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      <saleDate>06/01/2023</saleDate>
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      <grossProceeds>690758.47</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/01/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>02/27/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Joseph Ciaffoni</signature>
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144
0001443841
XXXXXXXX
LIVE
0001267565
COLLEGIUM PHARMACEUTICAL, INC
001-37372
100 TECHNOLOGY CENTER DRIVE
STOUGHTON
MA
02072
781-713-3699
Ciaffoni Joseph
Officer
Director
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
31272
698929.20
34594760
06/02/2023
NASDAQ
Common
02/10/2023
Restricted Stock Vesting
Issuer
N
31272
02/10/2023
Compensation
N
Joseph J. Ciaffoni
100 Technology Center Drive
Stoughton
MA
02072
Common
05/30/2023
31271
684906.77
Joseph J. Ciaffoni
100 Technology Center Drive
Stoughton
MA
02072
Common
05/31/2023
31272
683796.29
Joseph J. Ciaffoni
100 Technology Center Drive
Stoughton
MA
02072
Common
06/01/2023
31272
690758.47
06/01/2023
02/27/2023
/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Joseph Ciaffoni