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            <filer>
                <filerCredentials>
                    <cik>0001588862</cik>
                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001042074</issuerCik>
            <issuerName>CYMABAY THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-36500</secFileNumber>
            <issuerAddress>
                <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                <ns2:city>Newark</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94560</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 293-8800</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CHARLES MCWHERTER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>11332</noOfUnitsSold>
            <aggregateMarketValue>243440.46</aggregateMarketValue>
            <noOfUnitsOutstanding>113403353</noOfUnitsOutstanding>
            <approxSaleDate>12/18/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>12/18/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>11332</amountOfSecuritiesAcquired>
            <paymentDate>12/18/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHARLES MCWHERTER</name>
                <address>
                    <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                    <ns2:city>Newark</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94560</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/17/2023</saleDate>
            <amountOfSecuritiesSold>11342</amountOfSecuritiesSold>
            <grossProceeds>207293.20</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHARLES MCWHERTER</name>
                <address>
                    <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                    <ns2:city>Newark</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94560</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/18/2023</saleDate>
            <amountOfSecuritiesSold>21743</amountOfSecuritiesSold>
            <grossProceeds>305939.23</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>12/18/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/24/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>Charles McWherter</signature>
        </noticeSignature>
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144
0001588862
XXXXXXXX
LIVE
0001042074
CYMABAY THERAPEUTICS, INC.
001-36500
7575 Gateway Blvd, Suite 110
Newark
CA
94560
(510) 293-8800
CHARLES MCWHERTER
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
11332
243440.46
113403353
12/18/2023
NASDAQ
COMMON
12/18/2023
Stock Option Exercise
ISSUER
N
11332
12/18/2023
Cash
N
CHARLES MCWHERTER
7575 Gateway Blvd, Suite 110
Newark
CA
94560
Common
11/17/2023
11342
207293.20
CHARLES MCWHERTER
7575 Gateway Blvd, Suite 110
Newark
CA
94560
Common
10/18/2023
21743
305939.23
12/18/2023
02/24/2023
Charles McWherter