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    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001983476</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001974640</issuerCik>
            <issuerName>APOGEE THERAPEUTICS INC</issuerName>
            <secFileNumber>001-41740</secFileNumber>
            <issuerAddress>
                <ns2:street1>221 Crescent St., Building 17</ns2:street1>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02453</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6503945230</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CARL DAMBKOWSKI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>22345</noOfUnitsSold>
            <aggregateMarketValue>988989.70</aggregateMarketValue>
            <noOfUnitsOutstanding>46047416</noOfUnitsOutstanding>
            <approxSaleDate>07/02/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>07/02/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>11445</amountOfSecuritiesAcquired>
            <paymentDate>07/02/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/16/2022</acquiredDate>
            <natureOfAcquisitionTransaction>RSA</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10900</amountOfSecuritiesAcquired>
            <paymentDate>09/16/2022</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CARL DAMBKOWSKI</name>
                <address>
                    <ns2:street1>221 Crescent St., Building 17</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02453</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/04/2025</saleDate>
            <amountOfSecuritiesSold>2725</amountOfSecuritiesSold>
            <grossProceeds>100716.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CARL DAMBKOWSKI</name>
                <address>
                    <ns2:street1>221 Crescent St., Building 17</ns2:street1>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02453</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/07/2025</saleDate>
            <amountOfSecuritiesSold>2725</amountOfSecuritiesSold>
            <grossProceeds>97410.77</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>07/02/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/21/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Carl Dambkowski</signature>
        </noticeSignature>
    </formData>
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144
0001983476
XXXXXXXX
LIVE
0001974640
APOGEE THERAPEUTICS INC
001-41740
221 Crescent St., Building 17
Waltham
MA
02453
6503945230
CARL DAMBKOWSKI
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
22345
988989.70
46047416
07/02/2025
NASDAQ
Common
07/02/2025
Exercise of Stock Options
Issuer
N
11445
07/02/2025
Cash
Common
09/16/2022
RSA
Issuer
N
10900
09/16/2022
N/A
N
10b5-1 Sales for CARL DAMBKOWSKI
221 Crescent St., Building 17
Waltham
MA
02453
Common
06/04/2025
2725
100716.00
10b5-1 Sales for CARL DAMBKOWSKI
221 Crescent St., Building 17
Waltham
MA
02453
Common
05/07/2025
2725
97410.77
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
07/02/2025
08/21/2024
/s/ Carl Dambkowski