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      <issuerCik>0001410384</issuerCik>
      <issuerName>Q2 Holdings, Inc.</issuerName>
      <secFileNumber>001-36350</secFileNumber>
      <issuerAddress>
        <com:street1>10355 PECAN PARK BOULEVARD</com:street1>
        <com:city>Austin</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>78729</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>1-833-444-3469</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Seale R. H.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>245 Summer Street</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>22300</noOfUnitsSold>
      <aggregateMarketValue>742168.92</aggregateMarketValue>
      <noOfUnitsOutstanding>58198202</noOfUnitsOutstanding>
      <approxSaleDate>07/14/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>08/16/2004</acquiredDate>
      <natureOfAcquisitionTransaction>Initial Investment</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>22300</amountOfSecuritiesAcquired>
      <paymentDate>08/16/2004</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>RHS Investments - I LP</name>
        <address>
          <com:street1>c/o Q2 Holdings, Inc.</com:street1>
          <com:street2>10355 Pecan Park Boulevard</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78729</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>04/14/2023</saleDate>
      <amountOfSecuritiesSold>22300</amountOfSecuritiesSold>
      <grossProceeds>524408.49</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>RHS Investments - I LP</name>
        <address>
          <com:street1>c/o Q2 Holdings, Inc.</com:street1>
          <com:street2>10355 Pecan Park Boulevard</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78729</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>05/15/2023</saleDate>
      <amountOfSecuritiesSold>22300</amountOfSecuritiesSold>
      <grossProceeds>564628.52</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>RHS Investments - I LP</name>
        <address>
          <com:street1>c/o Q2 Holdings, Inc.</com:street1>
          <com:street2>10355 Pecan Park Boulevard</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78729</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>06/12/2023</saleDate>
      <amountOfSecuritiesSold>22300</amountOfSecuritiesSold>
      <grossProceeds>633453.06</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Shares sold for RHS Investments-I, LP where Robert H. Seale is President of Seale Inc., GP</remarks>
    <noticeSignature>
      <noticeDate>07/14/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>11/21/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Myra King, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Robert H. Seale</signature>
    </noticeSignature>
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144
0001597947
XXXXXXXX
LIVE
0001410384
Q2 Holdings, Inc.
001-36350
10355 PECAN PARK BOULEVARD
Austin
TX
78729
1-833-444-3469
Seale R. H.
Director
Common Stock
Fidelity Brokerage Services LLC
245 Summer Street
Boston
MA
02110
22300
742168.92
58198202
07/14/2023
NYSE
Common Stock
08/16/2004
Initial Investment
Issuer
N
22300
08/16/2004
Cash
N
RHS Investments - I LP
c/o Q2 Holdings, Inc.
10355 Pecan Park Boulevard
Austin
TX
78729
Common Stock
04/14/2023
22300
524408.49
RHS Investments - I LP
c/o Q2 Holdings, Inc.
10355 Pecan Park Boulevard
Austin
TX
78729
Common Stock
05/15/2023
22300
564628.52
RHS Investments - I LP
c/o Q2 Holdings, Inc.
10355 Pecan Park Boulevard
Austin
TX
78729
Common Stock
06/12/2023
22300
633453.06
Shares sold for RHS Investments-I, LP where Robert H. Seale is President of Seale Inc., GP
07/14/2023
11/21/2022
/s/ Myra King, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Robert H. Seale