<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001434577</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001046311</issuerCik>
            <issuerName>CHOICE HOTELS INTERNATIONAL, INC.</issuerName>
            <secFileNumber>001-13393</secFileNumber>
            <issuerAddress>
                <ns2:street1>915 Meeting Street Suite 600</ns2:street1>
                <ns2:city>North Bethesda</ns2:city>
                <ns2:stateOrCountry>MD</ns2:stateOrCountry>
                <ns2:zipCode>20852</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>3015925000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PATRICK PACIOUS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>44968</noOfUnitsSold>
            <aggregateMarketValue>6239759.68</aggregateMarketValue>
            <noOfUnitsOutstanding>47214338</noOfUnitsOutstanding>
            <approxSaleDate>11/04/2024</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/04/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>44968</amountOfSecuritiesAcquired>
            <paymentDate>11/04/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for PATRICK PACIOUS</name>
                <address>
                    <ns2:street1>915 Meeting Street Suite 600</ns2:street1>
                    <ns2:city>North Bethesda</ns2:city>
                    <ns2:stateOrCountry>MD</ns2:stateOrCountry>
                    <ns2:zipCode>20852</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/10/2024</saleDate>
            <amountOfSecuritiesSold>10025</amountOfSecuritiesSold>
            <grossProceeds>1206728.30</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>11/04/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/14/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Patrick Pacious</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4359}]
144
0001434577
XXXXXXXX
LIVE
0001046311
CHOICE HOTELS INTERNATIONAL, INC.
001-13393
915 Meeting Street Suite 600
North Bethesda
MD
20852
3015925000
PATRICK PACIOUS
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
44968
6239759.68
47214338
11/04/2024
NYSE
Common
11/04/2024
Exercise of Stock Options
Issuer
N
44968
11/04/2024
Cash
N
10b5-1 Sales for PATRICK PACIOUS
915 Meeting Street Suite 600
North Bethesda
MD
20852
Common
09/10/2024
10025
1206728.30
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
11/04/2024
03/14/2024
/s/ Patrick Pacious