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  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0002006362</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001840706</issuerCik>
      <issuerName>SOPHiA GENETICS SA</issuerName>
      <secFileNumber>001-40627</secFileNumber>
      <issuerAddress>
        <com:street1>La Piece 12 CH-1180</com:street1>
        <com:street2>Rolle</com:street2>
        <com:city>Switzerland</com:city>
        <com:stateOrCountry>XX</com:stateOrCountry>
        <com:zipCode>00000</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>41216941060</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Zhenyu Xu</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>13640</noOfUnitsSold>
      <aggregateMarketValue>67654.4</aggregateMarketValue>
      <noOfUnitsOutstanding>65230559</noOfUnitsOutstanding>
      <approxSaleDate>04/03/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <acquiredDate>04/03/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Vesting of Restricted Stock Units Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>SOPHiA GENETICS SA</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>13640</amountOfSecuritiesAcquired>
      <paymentDate>04/03/2024</paymentDate>
      <natureOfPayment>Vesting of Restricted Stock Unit Grant</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>01/18/2024</saleDate>
      <amountOfSecuritiesSold>93</amountOfSecuritiesSold>
      <grossProceeds>441.75</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>01/22/2024</saleDate>
      <amountOfSecuritiesSold>16</amountOfSecuritiesSold>
      <grossProceeds>76</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>02/18/2024</saleDate>
      <amountOfSecuritiesSold>93</amountOfSecuritiesSold>
      <grossProceeds>438.03</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>02/22/2024</saleDate>
      <amountOfSecuritiesSold>16</amountOfSecuritiesSold>
      <grossProceeds>76.8</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>03/14/2024</saleDate>
      <amountOfSecuritiesSold>8000</amountOfSecuritiesSold>
      <grossProceeds>36240</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>03/18/2024</saleDate>
      <amountOfSecuritiesSold>93</amountOfSecuritiesSold>
      <grossProceeds>414.78</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>03/22/2024</saleDate>
      <amountOfSecuritiesSold>111</amountOfSecuritiesSold>
      <grossProceeds>527.25</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The Reporting Person is selling the securities set forth herein pursuant to an automatic "sell to cover" transaction that did not represent a discretionary trade by the Reporting Person in order to pay the tax liability arising from the vesting and settlement of restricted stock units.</remarks>
    <noticeSignature>
      <noticeDate>04/03/2024</noticeDate>
      <signature>/s/ Zhenyu Xu</signature>
    </noticeSignature>
  </formData>
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144
0002006362
XXXXXXXX
LIVE
0001840706
SOPHiA GENETICS SA
001-40627
La Piece 12 CH-1180
Rolle
Switzerland
XX
00000
41216941060
Zhenyu Xu
Officer
ORDINARY
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
13640
67654.4
65230559
04/03/2024
NASDAQ
ORDINARY
04/03/2024
Vesting of Restricted Stock Units Grant
SOPHiA GENETICS SA
N
13640
04/03/2024
Vesting of Restricted Stock Unit Grant
N
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
ORDINARY
01/18/2024
93
441.75
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
ORDINARY
01/22/2024
16
76
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
ORDINARY
02/18/2024
93
438.03
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
ORDINARY
02/22/2024
16
76.8
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
ORDINARY
03/14/2024
8000
36240
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
ORDINARY
03/18/2024
93
414.78
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
ORDINARY
03/22/2024
111
527.25
The Reporting Person is selling the securities set forth herein pursuant to an automatic "sell to cover" transaction that did not represent a discretionary trade by the Reporting Person in order to pay the tax liability arising from the vesting and settlement of restricted stock units.
04/03/2024
/s/ Zhenyu Xu