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        <com:street1>101 SPEAR STREET</com:street1>
        <com:street2>SUITE 500</com:street2>
        <com:city>San Francisco</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94105</com:zipCode>
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      <issuerContactPhone>415-390-2337</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Viggiano Aidan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
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    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
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      <aggregateMarketValue>106739.00</aggregateMarketValue>
      <noOfUnitsOutstanding>181042862</noOfUnitsOutstanding>
      <approxSaleDate>02/15/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
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      <acquiredDate>02/15/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse - See Remarks</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>TWILIO INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
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      <paymentDate>02/15/2024</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
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        <name>AIDAN VIGGIANO</name>
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          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94105</com:zipCode>
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      <saleDate>11/15/2023</saleDate>
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      <grossProceeds>135390.00</grossProceeds>
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      <sellerDetails>
        <name>AIDAN VIGGIANO</name>
        <address>
          <com:street1>101 Spear Street, Fifth Floor</com:street1>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94105</com:zipCode>
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      <securitiesClassTitle>TWILIO INC</securitiesClassTitle>
      <saleDate>11/20/2023</saleDate>
      <amountOfSecuritiesSold>1121</amountOfSecuritiesSold>
      <grossProceeds>70062.00</grossProceeds>
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        <name>AIDAN VIGGIANO</name>
        <address>
          <com:street1>101 Spear Street, Fifth Floor</com:street1>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94105</com:zipCode>
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      <securitiesClassTitle>TWILIO INC</securitiesClassTitle>
      <saleDate>01/02/2024</saleDate>
      <amountOfSecuritiesSold>6581</amountOfSecuritiesSold>
      <grossProceeds>475141.00</grossProceeds>
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      <sellerDetails>
        <name>AIDAN VIGGIANO</name>
        <address>
          <com:street1>101 Spear Street, Fifth Floor</com:street1>
          <com:city>San Francisco,</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94105</com:zipCode>
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      <securitiesClassTitle>TWILIO INC</securitiesClassTitle>
      <saleDate>01/05/2024</saleDate>
      <amountOfSecuritiesSold>3025</amountOfSecuritiesSold>
      <grossProceeds>207138.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Shares sold to cover tax obligation from settlement of vested Restricted Stock Units.</remarks>
    <noticeSignature>
      <noticeDate>02/15/2024</noticeDate>
      <signature>AIDAN VIGGIANO</signature>
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144
0001965469
XXXXXXXX
LIVE
0001447669
TWILIO INC
001-37806
101 SPEAR STREET
SUITE 500
San Francisco
CA
94105
415-390-2337
Viggiano Aidan
Officer
Common
Charles Schwab & Co., Inc.
3000 Schwab Way
Westlake
TX
76262
1694
106739.00
181042862
02/15/2024
NYSE
Common
02/15/2024
Restricted Stock Lapse - See Remarks
TWILIO INC.
N
1694
02/15/2024
Equity Compensation
N
AIDAN VIGGIANO
101 Spear Street, Fifth Floor
San Francisco
CA
94105
TWILIO INC
11/15/2023
2187
135390.00
AIDAN VIGGIANO
101 Spear Street, Fifth Floor
San Francisco
CA
94105
TWILIO INC
11/20/2023
1121
70062.00
AIDAN VIGGIANO
101 Spear Street, Fifth Floor
San Francisco
CA
94105
TWILIO INC
01/02/2024
6581
475141.00
AIDAN VIGGIANO
101 Spear Street, Fifth Floor
San Francisco,
CA
94105
TWILIO INC
01/05/2024
3025
207138.00
Shares sold to cover tax obligation from settlement of vested Restricted Stock Units.
02/15/2024
AIDAN VIGGIANO