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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001484612</issuerCik>
            <issuerName>OUTSET MEDICAL, INC.</issuerName>
            <secFileNumber>001-39513</secFileNumber>
            <issuerAddress>
                <ns2:street1>3052 ORCHARD DRIVE</ns2:street1>
                <ns2:city>SAN JOSE</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>95134</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(669) 231-8200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JOHN BROTTEM</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2732</noOfUnitsSold>
            <aggregateMarketValue>54858.56</aggregateMarketValue>
            <noOfUnitsOutstanding>49228078</noOfUnitsOutstanding>
            <approxSaleDate>05/17/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
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        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>05/15/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1317</amountOfSecuritiesAcquired>
            <paymentDate>05/15/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>05/17/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1415</amountOfSecuritiesAcquired>
            <paymentDate>05/17/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JOHN BROTTEM</name>
                <address>
                    <ns2:street1>3052 ORCHARD DRIVE</ns2:street1>
                    <ns2:city>SAN JOSE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95134</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/16/2023</saleDate>
            <amountOfSecuritiesSold>1335</amountOfSecuritiesSold>
            <grossProceeds>26576.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JOHN BROTTEM</name>
                <address>
                    <ns2:street1>3052 ORCHARD DRIVE</ns2:street1>
                    <ns2:city>SAN JOSE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95134</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/03/2023</saleDate>
            <amountOfSecuritiesSold>1414</amountOfSecuritiesSold>
            <grossProceeds>28280.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JOHN BROTTEM</name>
                <address>
                    <ns2:street1>3052 ORCHARD DRIVE</ns2:street1>
                    <ns2:city>SAN JOSE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95134</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/20/2023</saleDate>
            <amountOfSecuritiesSold>4130</amountOfSecuritiesSold>
            <grossProceeds>85984.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/17/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/17/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>JOHN BROTTEM</signature>
        </noticeSignature>
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144
0001823381
XXXXXXXX
LIVE
0001484612
OUTSET MEDICAL, INC.
001-39513
3052 ORCHARD DRIVE
SAN JOSE
CA
95134
(669) 231-8200
JOHN BROTTEM
Officer
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
2732
54858.56
49228078
05/17/2023
NASD
COMMON
05/15/2023
Restricted Stock
ISSUER
N
1317
05/15/2023
Not Applicable
COMMON
05/17/2023
Stock Option Exercise
ISSUER
N
1415
05/17/2023
Cash
N
JOHN BROTTEM
3052 ORCHARD DRIVE
SAN JOSE
CA
95134
Common
05/16/2023
1335
26576.00
JOHN BROTTEM
3052 ORCHARD DRIVE
SAN JOSE
CA
95134
Common
05/03/2023
1414
28280.00
JOHN BROTTEM
3052 ORCHARD DRIVE
SAN JOSE
CA
95134
Common
03/20/2023
4130
85984.00
05/17/2023
02/17/2023
JOHN BROTTEM