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      <filer>
        <filerCredentials>
          <cik>0001214130</cik>
          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001576280</issuerCik>
      <issuerName>Guardant Health, Inc.</issuerName>
      <secFileNumber>001-38683</secFileNumber>
      <issuerAddress>
        <com:street1>3100 HANOVER STREET</com:street1>
        <com:city>PALO ALTO</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94304</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>855-698-8887</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>POTTER MYRTLE S</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2626</noOfUnitsSold>
      <aggregateMarketValue>130512.00</aggregateMarketValue>
      <noOfUnitsOutstanding>123888045</noOfUnitsOutstanding>
      <approxSaleDate>06/16/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/15/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse - See Remarks</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Guardant Health, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2626</amountOfSecuritiesAcquired>
      <paymentDate>12/15/2024</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Shares on this filing were acquired and paid for from 12/15/2024 through 06/12/2025.</remarks>
    <noticeSignature>
      <noticeDate>06/16/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>03/15/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>MYRTLE S POTTER</signature>
    </noticeSignature>
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144
0001214130
XXXXXXXX
LIVE
0001576280
Guardant Health, Inc.
001-38683
3100 HANOVER STREET
PALO ALTO
CA
94304
855-698-8887
POTTER MYRTLE S
Director
Common
Charles Schwab & Co., Inc.
3000 Schwab Way
Westlake
TX
76262
2626
130512.00
123888045
06/16/2025
NASDAQ
Common
12/15/2024
Restricted Stock Lapse - See Remarks
Guardant Health, Inc.
N
2626
12/15/2024
Equity Compensation
Y
Shares on this filing were acquired and paid for from 12/15/2024 through 06/12/2025.
06/16/2025
03/15/2025
MYRTLE S POTTER