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      <issuerCik>0001492691</issuerCik>
      <issuerName>Knight-Swift Transportation Holdings Inc.</issuerName>
      <secFileNumber>001-35007</secFileNumber>
      <issuerAddress>
        <com:street1>2002 West Wahalla Lane</com:street1>
        <com:city>PHOENIX</com:city>
        <com:stateOrCountry>AZ</com:stateOrCountry>
        <com:zipCode>85027</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>602-269-2000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SYNOWICKI ROBERT E JR</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
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    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab Corp</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2627</noOfUnitsSold>
      <aggregateMarketValue>140912.00</aggregateMarketValue>
      <noOfUnitsOutstanding>161864000</noOfUnitsOutstanding>
      <approxSaleDate>08/16/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/14/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Awards</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2627</amountOfSecuritiesAcquired>
      <paymentDate>05/14/2024</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
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    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>08/16/2024</noticeDate>
      <signature>Robert E. Synowicki Jr.</signature>
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144
0001233274
XXXXXXXX
LIVE
0001492691
Knight-Swift Transportation Holdings Inc.
001-35007
2002 West Wahalla Lane
PHOENIX
AZ
85027
602-269-2000
SYNOWICKI ROBERT E JR
Director
Common
Charles Schwab Corp
3000 Schwab Way
Westlake
TX
76262
2627
140912.00
161864000
08/16/2024
NYSE
Common
05/14/2024
Stock Awards
Issuer
N
2627
05/14/2024
Equity Compensation
Y
08/16/2024
Robert E. Synowicki Jr.