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            <secFileNumber>001-37985</secFileNumber>
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                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
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            <issuerContactPhone>(858) 362-6295</issuerContactPhone>
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                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
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            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <acquiredDate>02/16/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
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            <paymentDate>02/16/2024</paymentDate>
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                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/08/2024</saleDate>
            <amountOfSecuritiesSold>2305</amountOfSecuritiesSold>
            <grossProceeds>50274.59</grossProceeds>
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                    <ns2:zipCode>92121</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
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            <amountOfSecuritiesSold>882</amountOfSecuritiesSold>
            <grossProceeds>12515.58</grossProceeds>
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            <planAdoptionDates>
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144
0001239648
XXXXXXXX
LIVE
0001370053
ANAPTYSBIO, INC.
001-37985
10770 Wateridge Circle, Suite 210
San Diego
CA
92121
(858) 362-6295
ERIC J LOUMEAU
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
5000
125000.00
26575178
02/16/2024
NASDAQ
COMMON
02/16/2024
Stock Option Exercise
ISSUER
N
5000
02/16/2024
Cash
N
ERIC J LOUMEAU
10770 Wateridge Circle, Suite 210
San Diego
CA
92121
Common
01/08/2024
2305
50274.59
ERIC J LOUMEAU
10770 Wateridge Circle, Suite 210
San Diego
CA
92121
Common
11/22/2023
882
12515.58
02/16/2024
09/15/2023
ERIC J LOUMEAU