<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001569225</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001178879</issuerCik>
            <issuerName>AMICUS THERAPEUTICS INC</issuerName>
            <secFileNumber>001-33497</secFileNumber>
            <issuerAddress>
                <ns2:street1>3675 Market Street</ns2:street1>
                <ns2:city>Philadelphia</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19104</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>2159217600</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JEFFREY CASTELLI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>1575</noOfUnitsSold>
            <aggregateMarketValue>22727.25</aggregateMarketValue>
            <noOfUnitsOutstanding>293245738</noOfUnitsOutstanding>
            <approxSaleDate>12/28/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>10/19/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1575</amountOfSecuritiesAcquired>
            <paymentDate>10/19/2020</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JEFFREY CASTELLI</name>
                <address>
                    <ns2:street1>3675 Market Street</ns2:street1>
                    <ns2:city>Philadelphia</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/20/2023</saleDate>
            <amountOfSecuritiesSold>1654</amountOfSecuritiesSold>
            <grossProceeds>21667.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JEFFREY CASTELLI</name>
                <address>
                    <ns2:street1>3675 Market Street</ns2:street1>
                    <ns2:city>Philadelphia</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19104</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/19/2023</saleDate>
            <amountOfSecuritiesSold>17500</amountOfSecuritiesSold>
            <grossProceeds>231875.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 10/19/2020 through 01/04/2022</remarks>
        <noticeSignature>
            <noticeDate>12/28/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/25/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jeffrey Castelli</signature>
        </noticeSignature>
    </formData>
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144
0001569225
XXXXXXXX
LIVE
0001178879
AMICUS THERAPEUTICS INC
001-33497
3675 Market Street
Philadelphia
PA
19104
2159217600
JEFFREY CASTELLI
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
1575
22727.25
293245738
12/28/2023
NASDAQ
Common
10/19/2020
Restricted Stock Units
Issuer
N
1575
10/19/2020
N/A
N
10b5-1 Sales for JEFFREY CASTELLI
3675 Market Street
Philadelphia
PA
19104
Common
12/20/2023
1654
21667.40
10b5-1 Sales for JEFFREY CASTELLI
3675 Market Street
Philadelphia
PA
19104
Common
12/19/2023
17500
231875.00
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 10/19/2020 through 01/04/2022
12/28/2023
08/25/2023
/s/ Jeffrey Castelli