<?xml version="1.0" encoding="UTF-8"?><ns2:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:ns2="http://www.sec.gov/edgar/ownership">
    <ns2:headerData>
        <ns2:submissionType>144</ns2:submissionType>
        <ns2:filerInfo>
            <ns2:filer>
                <ns2:filerCredentials>
                    <ns2:cik>0001434805</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
                </ns2:filerCredentials>
            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



        </ns2:filerInfo>
    </ns2:headerData>
    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0001423689</ns2:issuerCik>
            <ns2:issuerName>AGNC Investment Corp.</ns2:issuerName>
            <ns2:secFileNumber>001-34057</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>2 Bethesda Metro Center</com:street1>
                <com:street2>12th Floor</com:street2>
                <com:city>Bethesda</com:city>
                <com:stateOrCountry>MD</com:stateOrCountry>
                <com:zipCode>20814</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>1-301-968-9315</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Gary Daniel Kain</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Officer</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>500000</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>4680000</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>595712000</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>05/10/2023</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>03/15/2020</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>1022</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>03/15/2020</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>03/15/2021</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>71164</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>03/15/2021</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>02/15/2022</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>277814</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>02/15/2022</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>03/22/2014</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>39580</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>03/22/2014</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>01/29/2015</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>4663</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>01/29/2015</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>02/18/2015</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>19604</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>02/18/2015</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>03/06/2015</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>72</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>03/06/2015</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>03/12/2015</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>26789</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>03/12/2015</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>03/12/2015</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>19501</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>03/12/2015</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>03/15/2015</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>6985</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>03/15/2015</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>03/22/2015</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Compensation -- Restricted Stock Units</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>32806</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>03/22/2015</ns2:paymentDate>
            <ns2:natureOfPayment>Compensation</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:noticeSignature>
            <ns2:noticeDate>05/10/2023</ns2:noticeDate>
            <ns2:planAdoptionDates/>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of Gary Daniel Kain</ns2:signature>
        </ns2:noticeSignature>
    </ns2:formData>
</ns2:edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 10388}]
144
0001434805
XXXXXXXX
LIVE
0001423689
AGNC Investment Corp.
001-34057
2 Bethesda Metro Center
12th Floor
Bethesda
MD
20814
1-301-968-9315
Gary Daniel Kain
Officer
Common
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
500000
4680000
595712000
05/10/2023
NASD
Common
03/15/2020
Compensation -- Restricted Stock Units
Issuer
N
1022
03/15/2020
Compensation
Common
03/15/2021
Compensation -- Restricted Stock Units
Issuer
N
71164
03/15/2021
Compensation
Common
02/15/2022
Compensation -- Restricted Stock Units
Issuer
N
277814
02/15/2022
Compensation
Common
03/22/2014
Compensation -- Restricted Stock Units
Issuer
N
39580
03/22/2014
Compensation
Common
01/29/2015
Compensation -- Restricted Stock Units
Issuer
N
4663
01/29/2015
Compensation
Common
02/18/2015
Compensation -- Restricted Stock Units
Issuer
N
19604
02/18/2015
Compensation
Common
03/06/2015
Compensation -- Restricted Stock Units
Issuer
N
72
03/06/2015
Compensation
Common
03/12/2015
Compensation -- Restricted Stock Units
Issuer
N
26789
03/12/2015
Compensation
Common
03/12/2015
Compensation -- Restricted Stock Units
Issuer
N
19501
03/12/2015
Compensation
Common
03/15/2015
Compensation -- Restricted Stock Units
Issuer
N
6985
03/15/2015
Compensation
Common
03/22/2015
Compensation -- Restricted Stock Units
Issuer
N
32806
03/22/2015
Compensation
Y
05/10/2023
Goldman Sachs & Co. LLC on behalf of Gary Daniel Kain