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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001744659</issuerCik>
            <issuerName>AKERO THERAPEUTICS INC</issuerName>
            <secFileNumber>001-38944</secFileNumber>
            <issuerAddress>
                <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                <ns2:city>South San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6504876488</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CATRIONA YALE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>30000</noOfUnitsSold>
            <aggregateMarketValue>1136400.00</aggregateMarketValue>
            <noOfUnitsOutstanding>79717570</noOfUnitsOutstanding>
            <approxSaleDate>05/15/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/15/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>30000</amountOfSecuritiesAcquired>
            <paymentDate>05/15/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CATRIONA YALE</name>
                <address>
                    <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/15/2025</saleDate>
            <amountOfSecuritiesSold>9073</amountOfSecuritiesSold>
            <grossProceeds>343965.60</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CATRIONA YALE</name>
                <address>
                    <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/17/2025</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>447608.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CATRIONA YALE</name>
                <address>
                    <ns2:street1>601 Gateway Boulevard, Suite 350</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/18/2025</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>498661.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
</remarks>
        <noticeSignature>
            <noticeDate>05/15/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/24/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Catriona Yale</signature>
        </noticeSignature>
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144
0001779308
XXXXXXXX
LIVE
0001744659
AKERO THERAPEUTICS INC
001-38944
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
6504876488
CATRIONA YALE
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
30000
1136400.00
79717570
05/15/2025
NASDAQ
Common
05/15/2025
Exercise of Stock Options
Issuer
N
30000
05/15/2025
Cash
N
10b5-1 Sales for CATRIONA YALE
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
Common
04/15/2025
9073
343965.60
10b5-1 Sales for CATRIONA YALE
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
Common
03/17/2025
10000
447608.00
10b5-1 Sales for CATRIONA YALE
601 Gateway Boulevard, Suite 350
South San Francisco
CA
94080
Common
02/18/2025
10000
498661.00
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
05/15/2025
05/24/2024
/s/ Catriona Yale