<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001864158</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001817713</issuerCik>
      <issuerName>Janux Therapeutics, Inc.</issuerName>
      <secFileNumber>001-40475</secFileNumber>
      <issuerAddress>
        <com:street1>10955 VISTA SORRENTO PARKWAY</com:street1>
        <com:street2>SUITE 200</com:street2>
        <com:city>SAN DIEGO</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92130</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(858) 751-4493</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Campbell David Alan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>THE CHARLES SCHWAB CORPORATION</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>5000</noOfUnitsSold>
      <aggregateMarketValue>300004.00</aggregateMarketValue>
      <noOfUnitsOutstanding>52482020</noOfUnitsOutstanding>
      <approxSaleDate>01/07/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>07/24/2017</acquiredDate>
      <natureOfAcquisitionTransaction>PRIVATE PLACEMENT</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
      <paymentDate>07/24/2017</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>DAVID ALAN CAMPBELL</name>
        <address>
          <com:street1>10955 Vista Sorrento Parkway</com:street1>
          <com:street2>Suite 200</com:street2>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>10/28/2024</saleDate>
      <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
      <grossProceeds>1338557.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>DAVID ALAN CAMPBELL</name>
        <address>
          <com:street1>10955 Vista Sorrento Parkway</com:street1>
          <com:street2>Suite 200</com:street2>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>11/25/2024</saleDate>
      <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
      <grossProceeds>1289880.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>DAVID ALAN CAMPBELL</name>
        <address>
          <com:street1>10955 Vista Sorrento Parkway</com:street1>
          <com:street2>Suite 200</com:street2>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>12/03/2024</saleDate>
      <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
      <grossProceeds>1005000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>DAVID ALAN CAMPBELL</name>
        <address>
          <com:street1>10955 Vista Sorrento Parkway</com:street1>
          <com:street2>Suite 200</com:street2>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>12/24/2024</saleDate>
      <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
      <grossProceeds>1404805.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>01/07/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>06/21/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>DAVID ALAN CAMPBELL</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5467}]
144
0001864158
XXXXXXXX
LIVE
0001817713
Janux Therapeutics, Inc.
001-40475
10955 VISTA SORRENTO PARKWAY
SUITE 200
SAN DIEGO
CA
92130
(858) 751-4493
Campbell David Alan
Officer
COMMON
THE CHARLES SCHWAB CORPORATION
3000 Schwab Way
Westlake
TX
76262
5000
300004.00
52482020
01/07/2025
NASDAQ
COMMON
07/24/2017
PRIVATE PLACEMENT
ISSUER
N
5000
07/24/2017
NA
N
DAVID ALAN CAMPBELL
10955 Vista Sorrento Parkway
Suite 200
San Diego
CA
92130
COMMON
10/28/2024
25000
1338557.00
DAVID ALAN CAMPBELL
10955 Vista Sorrento Parkway
Suite 200
San Diego
CA
92130
COMMON
11/25/2024
25000
1289880.00
DAVID ALAN CAMPBELL
10955 Vista Sorrento Parkway
Suite 200
San Diego
CA
92130
COMMON
12/03/2024
15000
1005000.00
DAVID ALAN CAMPBELL
10955 Vista Sorrento Parkway
Suite 200
San Diego
CA
92130
COMMON
12/24/2024
25000
1404805.00
01/07/2025
06/21/2024
DAVID ALAN CAMPBELL