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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerName>ANAPTYSBIO, INC.</issuerName>
            <secFileNumber>001-37985</secFileNumber>
            <issuerAddress>
                <ns2:street1>10770 Wateridge Circle, Suite 210</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92121</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(858) 362-6295</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PAUL F LIZZUL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>1500</noOfUnitsSold>
            <aggregateMarketValue>58005.00</aggregateMarketValue>
            <noOfUnitsOutstanding>27449316</noOfUnitsOutstanding>
            <approxSaleDate>09/23/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>09/23/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1500</amountOfSecuritiesAcquired>
            <paymentDate>09/23/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <name>PAUL F LIZZUL</name>
                <address>
                    <ns2:street1>10770 Wateridge Circle, Suite 210</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>09/16/2024</saleDate>
            <amountOfSecuritiesSold>2220</amountOfSecuritiesSold>
            <grossProceeds>86437.73</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>PAUL F LIZZUL</name>
                <address>
                    <ns2:street1>10770 Wateridge Circle, Suite 210</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>08/14/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>80000.00</grossProceeds>
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                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/18/2024</saleDate>
            <amountOfSecuritiesSold>1500</amountOfSecuritiesSold>
            <grossProceeds>52500.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>09/23/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>06/10/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Paul F Lizzul</signature>
        </noticeSignature>
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144
0001711462
XXXXXXXX
LIVE
0001370053
ANAPTYSBIO, INC.
001-37985
10770 Wateridge Circle, Suite 210
San Diego
CA
92121
(858) 362-6295
PAUL F LIZZUL
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
1500
58005.00
27449316
09/23/2024
NASDAQ
COMMON
09/23/2024
Stock Option Exercise
ISSUER
N
1500
09/23/2024
Cash
N
PAUL F LIZZUL
10770 Wateridge Circle, Suite 210
San Diego
CA
92121
Common
09/16/2024
2220
86437.73
PAUL F LIZZUL
10770 Wateridge Circle, Suite 210
San Diego
CA
92121
Common
08/14/2024
2000
80000.00
PAUL F LIZZUL
10770 Wateridge Circle, Suite 210
San Diego
CA
92121
Common
07/18/2024
1500
52500.00
09/23/2024
06/10/2024
/s/ Paul F Lizzul