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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001178879</issuerCik>
            <issuerName>AMICUS THERAPEUTICS INC</issuerName>
            <secFileNumber>001-33497</secFileNumber>
            <issuerAddress>
                <ns2:street1>47 Hulfish Street</ns2:street1>
                <ns2:city>Princeton</ns2:city>
                <ns2:stateOrCountry>NJ</ns2:stateOrCountry>
                <ns2:zipCode>08542</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>609-662-2000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ELLEN ROSENBERG</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>30000</noOfUnitsSold>
            <aggregateMarketValue>381000.00</aggregateMarketValue>
            <noOfUnitsOutstanding>293245738</noOfUnitsOutstanding>
            <approxSaleDate>02/06/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/06/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>30000</amountOfSecuritiesAcquired>
            <paymentDate>02/06/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <address>
                    <ns2:street1>47 Hulfish Street</ns2:street1>
                    <ns2:city>Princeton</ns2:city>
                    <ns2:stateOrCountry>NJ</ns2:stateOrCountry>
                    <ns2:zipCode>08542</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>01/02/2024</saleDate>
            <amountOfSecuritiesSold>30000</amountOfSecuritiesSold>
            <grossProceeds>426219.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ELLEN ROSENBERG</name>
                <address>
                    <ns2:street1>47 Hulfish Street</ns2:street1>
                    <ns2:city>Princeton</ns2:city>
                    <ns2:stateOrCountry>NJ</ns2:stateOrCountry>
                    <ns2:zipCode>08542</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>12/27/2023</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>70327.00</grossProceeds>
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                    <ns2:stateOrCountry>NJ</ns2:stateOrCountry>
                    <ns2:zipCode>08542</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>12/26/2023</saleDate>
            <amountOfSecuritiesSold>30000</amountOfSecuritiesSold>
            <grossProceeds>420084.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>02/06/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/08/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Ellen Rosenberg</signature>
        </noticeSignature>
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144
0001666380
XXXXXXXX
LIVE
0001178879
AMICUS THERAPEUTICS INC
001-33497
47 Hulfish Street
Princeton
NJ
08542
609-662-2000
ELLEN ROSENBERG
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
30000
381000.00
293245738
02/06/2024
NASDAQ
Common
02/06/2024
Exercise of Stock Options
Issuer
N
30000
02/06/2024
Cash
N
10b5-1 Sales for ELLEN ROSENBERG
47 Hulfish Street
Princeton
NJ
08542
COMMON
01/02/2024
30000
426219.00
10b5-1 Sales for ELLEN ROSENBERG
47 Hulfish Street
Princeton
NJ
08542
COMMON
12/27/2023
5000
70327.00
10b5-1 Sales for ELLEN ROSENBERG
47 Hulfish Street
Princeton
NJ
08542
COMMON
12/26/2023
30000
420084.00
02/06/2024
09/08/2023
/s/ Ellen Rosenberg