<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001899922</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001093557</issuerCik>
            <issuerName>DEXCOM, INC.</issuerName>
            <secFileNumber>000-51222</secFileNumber>
            <issuerAddress>
                <ns2:street1>6340 Sequence Drive</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92121</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(858) 200-0200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MICHAEL BROWN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>500</noOfUnitsSold>
            <aggregateMarketValue>41400.00</aggregateMarketValue>
            <noOfUnitsOutstanding>392107501</noOfUnitsOutstanding>
            <approxSaleDate>06/16/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/08/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>500</amountOfSecuritiesAcquired>
            <paymentDate>03/08/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>MICHAEL BROWN</name>
                <address>
                    <ns2:street1>6340 Sequence Drive</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/23/2025</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>842849.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/16/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/21/2025</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Michael Jon Brown</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001899922
XXXXXXXX
LIVE
0001093557
DEXCOM, INC.
000-51222
6340 Sequence Drive
San Diego
CA
92121
(858) 200-0200
MICHAEL BROWN
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
500
41400.00
392107501
06/16/2025
NASDAQ
Common
03/08/2024
Restricted Stock
ISSUER
N
500
03/08/2024
Not Applicable
N
MICHAEL BROWN
6340 Sequence Drive
San Diego
CA
92121
Common
05/23/2025
10000
842849.00
06/16/2025
02/21/2025
/s/ Michael Jon Brown