<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001724605</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001714899</issuerCik>
            <issuerName>DENALI THERAPEUTICS INC</issuerName>
            <secFileNumber>001-38311</secFileNumber>
            <issuerAddress>
                <ns2:street1>161 Oyster Point Blvd.</ns2:street1>
                <ns2:city>South San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6508668548</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CAROLE HO</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>4668</noOfUnitsSold>
            <aggregateMarketValue>92146.32</aggregateMarketValue>
            <noOfUnitsOutstanding>138196848</noOfUnitsOutstanding>
            <approxSaleDate>01/10/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/03/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3256</amountOfSecuritiesAcquired>
            <paymentDate>01/03/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/04/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1412</amountOfSecuritiesAcquired>
            <paymentDate>01/04/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CAROLE HO</name>
                <address>
                    <ns2:street1>161 Oyster Point Blvd.</ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/05/2024</saleDate>
            <amountOfSecuritiesSold>9972</amountOfSecuritiesSold>
            <grossProceeds>193755.96</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>01/10/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/29/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Carole Ho</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4587}]
144
0001724605
XXXXXXXX
LIVE
0001714899
DENALI THERAPEUTICS INC
001-38311
161 Oyster Point Blvd.
South San Francisco
CA
94080
6508668548
CAROLE HO
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
4668
92146.32
138196848
01/10/2024
NASDAQ
Common
01/03/2024
Restricted Stock Units
Issuer
N
3256
01/03/2024
N/A
Common
01/04/2024
Restricted Stock Units
Issuer
N
1412
01/04/2024
N/A
N
CAROLE HO
161 Oyster Point Blvd.
South San Francisco
CA
94080
Common
01/05/2024
9972
193755.96
01/10/2024
09/29/2023
/s/ Carole Ho