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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001505545</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000740260</issuerCik>
      <issuerName>Ventas, Inc.</issuerName>
      <secFileNumber>001-10989</secFileNumber>
      <issuerAddress>
        <com:street1>353 N. CLARK STREET</com:street1>
        <com:street2>SUITE 3300</com:street2>
        <com:city>CHICAGO</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60654</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>3126603800</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Cobb John D.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co. Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>50000</noOfUnitsSold>
      <aggregateMarketValue>2391000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>399993581</noOfUnitsOutstanding>
      <approxSaleDate>04/28/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/24/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Ventas Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>3609</amountOfSecuritiesAcquired>
      <paymentDate>02/24/2021</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/24/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Ventas Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6878</amountOfSecuritiesAcquired>
      <paymentDate>02/24/2021</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/27/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Ventas Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2522</amountOfSecuritiesAcquired>
      <paymentDate>01/27/2018</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/18/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Ventas Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4035</amountOfSecuritiesAcquired>
      <paymentDate>01/18/2018</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/18/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Ventas Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>7547</amountOfSecuritiesAcquired>
      <paymentDate>01/18/2018</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/24/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Ventas Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6478</amountOfSecuritiesAcquired>
      <paymentDate>02/24/2022</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/25/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Ventas Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11059</amountOfSecuritiesAcquired>
      <paymentDate>01/25/2022</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/01/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Ventas Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>3799</amountOfSecuritiesAcquired>
      <paymentDate>02/01/2023</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/25/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Ventas Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4073</amountOfSecuritiesAcquired>
      <paymentDate>01/25/2023</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>John D Cobb</name>
        <address>
          <com:street1>416 W Deming Place</com:street1>
          <com:street2>Unit 3</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60614</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Ventas Inc.</securitiesClassTitle>
      <saleDate>04/11/2023</saleDate>
      <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
      <grossProceeds>551495.95</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>John D Cobb</name>
        <address>
          <com:street1>416 W Deming Place</com:street1>
          <com:street2>Unit 3</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60614</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Ventas Inc.</securitiesClassTitle>
      <saleDate>04/24/2023</saleDate>
      <amountOfSecuritiesSold>20000</amountOfSecuritiesSold>
      <grossProceeds>905740.90</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>sec electronic filing reviewed all in good order</remarks>
    <noticeSignature>
      <noticeDate>04/28/2023</noticeDate>
      <signature>John D Cobb</signature>
    </noticeSignature>
  </formData>
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144
0001505545
XXXXXXXX
LIVE
0000740260
Ventas, Inc.
001-10989
353 N. CLARK STREET
SUITE 3300
CHICAGO
IL
60654
3126603800
Cobb John D.
Officer
Common
Charles Schwab & Co. Inc.
3000 Schwab Way
Westlake
TX
76262
50000
2391000.00
399993581
04/28/2023
NYSE
Common
02/24/2021
Restricted Stock Award
Ventas Inc.
N
3609
02/24/2021
N/A
Common
02/24/2021
Restricted Stock Award
Ventas Inc.
N
6878
02/24/2021
N/A
Common
01/27/2018
Restricted Stock Award
Ventas Inc.
N
2522
01/27/2018
N/A
Common
01/18/2018
Restricted Stock Award
Ventas Inc.
N
4035
01/18/2018
N/A
Common
01/18/2018
Restricted Stock Award
Ventas Inc.
N
7547
01/18/2018
N/A
Common
02/24/2022
Restricted Stock Award
Ventas Inc.
N
6478
02/24/2022
N/A
Common
01/25/2022
Restricted Stock Award
Ventas Inc.
N
11059
01/25/2022
N/A
Common
02/01/2023
Restricted Stock Award
Ventas Inc.
N
3799
02/01/2023
N/A
Common
01/25/2023
Restricted Stock Award
Ventas Inc.
N
4073
01/25/2023
N/A
N
John D Cobb
416 W Deming Place
Unit 3
Chicago
IL
60614
Ventas Inc.
04/11/2023
10000
551495.95
John D Cobb
416 W Deming Place
Unit 3
Chicago
IL
60614
Ventas Inc.
04/24/2023
20000
905740.90
sec electronic filing reviewed all in good order
04/28/2023
John D Cobb