<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001222357</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0000805928</issuerCik>
            <issuerName>AXOGEN INC.</issuerName>
            <secFileNumber>001-36046</secFileNumber>
            <issuerAddress>
                <ns2:street1>13631 Progress Blvd.</ns2:street1>
                <ns2:street2>Suite 400</ns2:street2>
                <ns2:city>Alachua</ns2:city>
                <ns2:stateOrCountry>FL</ns2:stateOrCountry>
                <ns2:zipCode>32615</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>386-462-6800</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PETER J MARIANI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>12500</noOfUnitsSold>
            <aggregateMarketValue>93810.00</aggregateMarketValue>
            <noOfUnitsOutstanding>43043606</noOfUnitsOutstanding>
            <approxSaleDate>12/11/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/15/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2207</amountOfSecuritiesAcquired>
            <paymentDate>02/15/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>07/18/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2763</amountOfSecuritiesAcquired>
            <paymentDate>07/18/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/20/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1143</amountOfSecuritiesAcquired>
            <paymentDate>12/20/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/30/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Shares Purchased through Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3000</amountOfSecuritiesAcquired>
            <paymentDate>06/30/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/16/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1410</amountOfSecuritiesAcquired>
            <paymentDate>03/16/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/27/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1977</amountOfSecuritiesAcquired>
            <paymentDate>12/27/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Peter Mariani</name>
                <address>
                    <ns2:street1>13631 Progress Blvd.</ns2:street1>
                    <ns2:street2>Suite 400</ns2:street2>
                    <ns2:city>Alachua</ns2:city>
                    <ns2:stateOrCountry>FL</ns2:stateOrCountry>
                    <ns2:zipCode>32615</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/12/2023</saleDate>
            <amountOfSecuritiesSold>24</amountOfSecuritiesSold>
            <grossProceeds>97.47</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Peter Mariani</name>
                <address>
                    <ns2:street1>13631 Progress Blvd.</ns2:street1>
                    <ns2:street2>Suite 400</ns2:street2>
                    <ns2:city>Alachua</ns2:city>
                    <ns2:stateOrCountry>FL</ns2:stateOrCountry>
                    <ns2:zipCode>32615</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/12/2023</saleDate>
            <amountOfSecuritiesSold>3239</amountOfSecuritiesSold>
            <grossProceeds>12968.29</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>12/11/2023</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Peter James Mariani</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 7775}]
144
0001222357
XXXXXXXX
LIVE
0000805928
AXOGEN INC.
001-36046
13631 Progress Blvd.
Suite 400
Alachua
FL
32615
386-462-6800
PETER J MARIANI
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
12500
93810.00
43043606
12/11/2023
NASDAQ
Common
02/15/2022
Performance Stock Units
Issuer
N
2207
02/15/2022
Cash
Common
07/18/2022
Performance Stock Units
Issuer
N
2763
07/18/2022
Cash
Common
12/20/2021
Restricted stock vesting under a registered plan
Issuer
N
1143
12/20/2021
Cash
Common
06/30/2022
Shares Purchased through Employee Stock Purchase Plan
Issuer
N
3000
06/30/2022
Cash
Common
03/16/2022
Restricted stock vesting under a registered plan
Issuer
N
1410
03/16/2022
Cash
Common
12/27/2021
Restricted stock vesting under a registered plan
Issuer
N
1977
12/27/2021
Cash
N
Peter Mariani
13631 Progress Blvd.
Suite 400
Alachua
FL
32615
Common
10/12/2023
24
97.47
Peter Mariani
13631 Progress Blvd.
Suite 400
Alachua
FL
32615
Common
10/12/2023
3239
12968.29
12/11/2023
/s/ Peter James Mariani