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      <filer>
        <filerCredentials>
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          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>


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      <issuerCik>0001157601</issuerCik>
      <issuerName>MADRIGAL PHARMACEUTICALS, INC.</issuerName>
      <secFileNumber>001-33277</secFileNumber>
      <issuerAddress>
        <com:street1>200 BARR HARBOR DRIVE, SUITE 400</com:street1>
        <com:city>WEST CONSHOHOCKEN</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>19428</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>404-380-9263</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Gollust Keith R</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>245 Summer Street</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>5000</noOfUnitsSold>
      <aggregateMarketValue>1105300.00</aggregateMarketValue>
      <noOfUnitsOutstanding>18289173</noOfUnitsOutstanding>
      <approxSaleDate>07/12/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/15/2008</acquiredDate>
      <natureOfAcquisitionTransaction>Private placement</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
      <paymentDate>07/15/2008</paymentDate>
      <natureOfPayment>Cash/ check</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Keith Gollust</name>
        <address>
          <com:street1>Four Tower Bridge</com:street1>
          <com:street2>200 Barr Harbor Dr, Suite 200</com:street2>
          <com:city>West Conshohocken</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19428</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/26/2023</saleDate>
      <amountOfSecuritiesSold>55452</amountOfSecuritiesSold>
      <grossProceeds>13043418.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>07/12/2023</noticeDate>
      <signature>/s/ Cristina Garcia as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Keith Gollust</signature>
    </noticeSignature>
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144
0001325712
XXXXXXXX
LIVE
0001157601
MADRIGAL PHARMACEUTICALS, INC.
001-33277
200 BARR HARBOR DRIVE, SUITE 400
WEST CONSHOHOCKEN
PA
19428
404-380-9263
Gollust Keith R
Director
Common
Fidelity Brokerage Services LLC
245 Summer Street
Boston
MA
02110
5000
1105300.00
18289173
07/12/2023
NASDAQ
Common
07/15/2008
Private placement
Issuer
N
5000
07/15/2008
Cash/ check
N
Keith Gollust
Four Tower Bridge
200 Barr Harbor Dr, Suite 200
West Conshohocken
PA
19428
Common
06/26/2023
55452
13043418.00
07/12/2023
/s/ Cristina Garcia as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Keith Gollust