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            <filer>
                <filerCredentials>
                    <cik>0001815366</cik>
                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001808158</issuerCik>
            <issuerName>REPARE THERAPEUTICS INC</issuerName>
            <secFileNumber>001-39335</secFileNumber>
            <issuerAddress>
                <ns2:street1>7171 Frederick-Banting</ns2:street1>
                <ns2:street2>Building 2, Suite 270</ns2:street2>
                <ns2:city>St-Laurent, Qu?bec</ns2:city>
                <ns2:stateOrCountry>A8</ns2:stateOrCountry>
                <ns2:zipCode>H4S 1Z9</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8574127018</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MICHAEL ZINDA</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2210</noOfUnitsSold>
            <aggregateMarketValue>10806.90</aggregateMarketValue>
            <noOfUnitsOutstanding>42182177</noOfUnitsOutstanding>
            <approxSaleDate>03/25/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/30/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2210</amountOfSecuritiesAcquired>
            <paymentDate>01/30/2023</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>03/25/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/22/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Michael Zinda</signature>
        </noticeSignature>
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144
0001815366
XXXXXXXX
LIVE
0001808158
REPARE THERAPEUTICS INC
001-39335
7171 Frederick-Banting
Building 2, Suite 270
St-Laurent, Qu?bec
A8
H4S 1Z9
8574127018
MICHAEL ZINDA
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
2210
10806.90
42182177
03/25/2024
NASDAQ
Common
01/30/2023
Restricted Stock Units
Issuer
N
2210
01/30/2023
N/A
Y
03/25/2024
12/22/2023
/s/ Michael Zinda