<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001611303</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0000822818</issuerCik>
            <issuerName>CLEAN HARBORS, INC.</issuerName>
            <secFileNumber>001-34223</secFileNumber>
            <issuerAddress>
                <ns2:street1>42 Longwater Drive</ns2:street1>
                <ns2:city>Norwell</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02061</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(781) 792-5000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JOHN R WELCH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>1000</noOfUnitsSold>
            <aggregateMarketValue>150430.60</aggregateMarketValue>
            <noOfUnitsOutstanding>54104121</noOfUnitsOutstanding>
            <approxSaleDate>06/02/2023</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/08/2017</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>104</amountOfSecuritiesAcquired>
            <paymentDate>06/08/2017</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/07/2018</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>896</amountOfSecuritiesAcquired>
            <paymentDate>06/07/2018</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/02/2023</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ John R. Welch</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001611303
XXXXXXXX
LIVE
0000822818
CLEAN HARBORS, INC.
001-34223
42 Longwater Drive
Norwell
MA
02061
(781) 792-5000
JOHN R WELCH
Director
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
1000
150430.60
54104121
06/02/2023
NYSE
Common
06/08/2017
Restricted Stock
Issuer
N
104
06/08/2017
Not Applicable
Common
06/07/2018
Restricted Stock
Issuer
N
896
06/07/2018
Not Applicable
Y
06/02/2023
/s/ John R. Welch