<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001558242</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001107843</issuerCik>
            <issuerName>QUALYS, INC.</issuerName>
            <secFileNumber>001-35662</secFileNumber>
            <issuerAddress>
                <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                <ns2:city> Foster City</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94404</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6508016100</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SUMEDH THAKAR</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>21000</noOfUnitsSold>
            <aggregateMarketValue>2963730.00</aggregateMarketValue>
            <noOfUnitsOutstanding>36590452</noOfUnitsOutstanding>
            <approxSaleDate>02/14/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/14/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>21000</amountOfSecuritiesAcquired>
            <paymentDate>02/14/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for SUMEDH THAKAR</name>
                <address>
                    <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                    <ns2:city> Foster City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94404</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/14/2025</saleDate>
            <amountOfSecuritiesSold>7000</amountOfSecuritiesSold>
            <grossProceeds>941413.90</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for SUMEDH THAKAR</name>
                <address>
                    <ns2:street1>919 E. Hillsdale Boulevard, 4th Floor</ns2:street1>
                    <ns2:city> Foster City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94404</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/16/2024</saleDate>
            <amountOfSecuritiesSold>7000</amountOfSecuritiesSold>
            <grossProceeds>1030137.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>02/14/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/28/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Sumedh Thakar</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001558242
XXXXXXXX
LIVE
0001107843
QUALYS, INC.
001-35662
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
6508016100
SUMEDH THAKAR
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
21000
2963730.00
36590452
02/14/2025
NASDAQ
Common
02/14/2025
Exercise of Stock Options
Issuer
N
21000
02/14/2025
Cash
N
10b5-1 Sales Plan for SUMEDH THAKAR
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
Common
01/14/2025
7000
941413.90
10b5-1 Sales Plan for SUMEDH THAKAR
919 E. Hillsdale Boulevard, 4th Floor
Foster City
CA
94404
Common
12/16/2024
7000
1030137.50
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
02/14/2025
02/28/2024
/s/ Sumedh Thakar