<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001331453</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001287865</issuerCik>
      <issuerName>MEDICAL PROPERTIES TRUST INC</issuerName>
      <secFileNumber>001-32559</secFileNumber>
      <issuerAddress>
        <com:street1>1000 URBAN CENTER DRIVE</com:street1>
        <com:street2>SUITE 501</com:street2>
        <com:city>BIRMINGHAM</com:city>
        <com:stateOrCountry>AL</com:stateOrCountry>
        <com:zipCode>35242</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>205-969-3755</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Stewart Michael G</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab Corp.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>32780</noOfUnitsSold>
      <aggregateMarketValue>179962.20</aggregateMarketValue>
      <noOfUnitsOutstanding>600200000</noOfUnitsOutstanding>
      <approxSaleDate>10/09/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>309</amountOfSecuritiesAcquired>
      <paymentDate>10/01/2016</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/01/2017</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>309</amountOfSecuritiesAcquired>
      <paymentDate>01/01/2017</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>04/01/2017</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>915</amountOfSecuritiesAcquired>
      <paymentDate>04/01/2017</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/01/2017</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>915</amountOfSecuritiesAcquired>
      <paymentDate>07/01/2017</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/01/2017</acquiredDate>
      <natureOfAcquisitionTransaction>Copmensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Isssuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>915</amountOfSecuritiesAcquired>
      <paymentDate>10/01/2017</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/01/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>915</amountOfSecuritiesAcquired>
      <paymentDate>01/01/2018</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>04/01/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>915</amountOfSecuritiesAcquired>
      <paymentDate>04/01/2018</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/01/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2289</amountOfSecuritiesAcquired>
      <paymentDate>07/01/2018</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/01/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Copmensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1602</amountOfSecuritiesAcquired>
      <paymentDate>10/01/2018</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/01/2019</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1598</amountOfSecuritiesAcquired>
      <paymentDate>01/01/2019</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>04/01/2019</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1811</amountOfSecuritiesAcquired>
      <paymentDate>04/01/2019</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/01/2019</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1811</amountOfSecuritiesAcquired>
      <paymentDate>07/01/2019</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/01/2019</acquiredDate>
      <natureOfAcquisitionTransaction>Copmensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1811</amountOfSecuritiesAcquired>
      <paymentDate>10/01/2019</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/01/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1802</amountOfSecuritiesAcquired>
      <paymentDate>01/01/2020</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>04/01/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1642</amountOfSecuritiesAcquired>
      <paymentDate>04/01/2020</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/01/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1642</amountOfSecuritiesAcquired>
      <paymentDate>07/01/2020</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/01/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1642</amountOfSecuritiesAcquired>
      <paymentDate>10/01/2020</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/01/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1640</amountOfSecuritiesAcquired>
      <paymentDate>01/01/2021</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>04/01/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1449</amountOfSecuritiesAcquired>
      <paymentDate>04/01/2021</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/01/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1449</amountOfSecuritiesAcquired>
      <paymentDate>07/01/2021</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/01/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1449</amountOfSecuritiesAcquired>
      <paymentDate>10/01/2021</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/01/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1439</amountOfSecuritiesAcquired>
      <paymentDate>01/01/2022</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>04/01/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1394</amountOfSecuritiesAcquired>
      <paymentDate>04/01/2022</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/01/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1117</amountOfSecuritiesAcquired>
      <paymentDate>07/01/2022</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/09/2024</noticeDate>
      <signature>MICHAEL STEWART</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 14631}]
144
0001331453
XXXXXXXX
LIVE
0001287865
MEDICAL PROPERTIES TRUST INC
001-32559
1000 URBAN CENTER DRIVE
SUITE 501
BIRMINGHAM
AL
35242
205-969-3755
Stewart Michael G
Director
Common
Charles Schwab Corp.
3000 Schwab Way
Westlake
TX
76262
32780
179962.20
600200000
10/09/2024
NYSE
Common
10/01/2016
Compensation
Issuer
N
309
10/01/2016
N/A
Common
01/01/2017
Compensation
Issuer
N
309
01/01/2017
N/A
Common
04/01/2017
Compensation
Issuer
N
915
04/01/2017
N/A
Common
07/01/2017
Compensation
Issuer
N
915
07/01/2017
N/A
Common
10/01/2017
Copmensation
Isssuer
N
915
10/01/2017
N/A
Common
01/01/2018
Compensation
Issuer
N
915
01/01/2018
N/A
Common
04/01/2018
Compensation
Issuer
N
915
04/01/2018
N/A
Common
07/01/2018
Compensation
Issuer
N
2289
07/01/2018
N/A
Common
10/01/2018
Copmensation
Issuer
N
1602
10/01/2018
N/A
Common
01/01/2019
Compensation
Issuer
N
1598
01/01/2019
N/A
Common
04/01/2019
Compensation
Issuer
N
1811
04/01/2019
N/A
Common
07/01/2019
Compensation
Issuer
N
1811
07/01/2019
N/A
Common
10/01/2019
Copmensation
Issuer
N
1811
10/01/2019
N/A
Common
01/01/2020
Compensation
Issuer
N
1802
01/01/2020
N/A
Common
04/01/2020
Compensation
Issuer
N
1642
04/01/2020
N/A
Common
07/01/2020
Compensation
Issuer
N
1642
07/01/2020
N/A
Common
10/01/2020
Compensation
Issuer
N
1642
10/01/2020
N/A
Common
01/01/2021
Compensation
Issuer
N
1640
01/01/2021
N/A
Common
04/01/2021
Compensation
Issuer
N
1449
04/01/2021
N/A
Common
07/01/2021
Compensation
Issuer
N
1449
07/01/2021
N/A
Common
10/01/2021
Compensation
Issuer
N
1449
10/01/2021
N/A
Common
01/01/2022
Compensation
Issuer
N
1439
01/01/2022
N/A
Common
04/01/2022
Compensation
Issuer
N
1394
04/01/2022
N/A
Common
07/01/2022
Compensation
Issuer
N
1117
07/01/2022
N/A
Y
10/09/2024
MICHAEL STEWART