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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001762749</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001768224</issuerCik>
            <issuerName>ARCTURUS THERAPEUTICS HOLDINGS  INC.</issuerName>
            <secFileNumber>001-38942</secFileNumber>
            <issuerAddress>
                <ns2:street1>10628 SCIENCE CENTER DRIVE, SUITE 250</ns2:street1>
                <ns2:city>SAN DIEGO</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92121</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(858) 900-2660</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KEITH C KUMMERFELD</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>6968</noOfUnitsSold>
            <aggregateMarketValue>243880.00</aggregateMarketValue>
            <noOfUnitsOutstanding>26562951</noOfUnitsOutstanding>
            <approxSaleDate>07/14/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>07/14/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6968</amountOfSecuritiesAcquired>
            <paymentDate>07/14/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>KEITH C KUMMERFELD</name>
                <address>
                    <ns2:street1>10628 SCIENCE CENTER DRIVE, SUITE 250</ns2:street1>
                    <ns2:city>SAN DIEGO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/17/2023</saleDate>
            <amountOfSecuritiesSold>6968</amountOfSecuritiesSold>
            <grossProceeds>196342.91</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>07/14/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/16/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Keith Carl Kummerfeld</signature>
        </noticeSignature>
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144
0001762749
XXXXXXXX
LIVE
0001768224
ARCTURUS THERAPEUTICS HOLDINGS  INC.
001-38942
10628 SCIENCE CENTER DRIVE, SUITE 250
SAN DIEGO
CA
92121
(858) 900-2660
KEITH C KUMMERFELD
Officer
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
6968
243880.00
26562951
07/14/2023
NASD
COMMON
07/14/2023
Stock Option Exercise
ISSUER
N
6968
07/14/2023
Cash
N
KEITH C KUMMERFELD
10628 SCIENCE CENTER DRIVE, SUITE 250
SAN DIEGO
CA
92121
Common
04/17/2023
6968
196342.91
07/14/2023
12/16/2022
/s/ Keith Carl Kummerfeld