<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001592280</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001679363</issuerCik>
            <issuerName>MORPHIC HOLDING, INC.</issuerName>
            <secFileNumber>001-38940</secFileNumber>
            <issuerAddress>
                <ns2:street1>35 GATEHOUSE DRIVE, A2</ns2:street1>
                <ns2:city>WALTHAM,</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02451</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(781) 996-0955</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROBERT FARRELL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>20000</noOfUnitsSold>
            <aggregateMarketValue>850002.00</aggregateMarketValue>
            <noOfUnitsOutstanding>39534138</noOfUnitsOutstanding>
            <approxSaleDate>04/17/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>12/05/2018</acquiredDate>
            <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
            <paymentDate>12/05/2018</paymentDate>
            <natureOfPayment>NONE</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>11/03/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Exercised Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
            <paymentDate>11/03/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT FARRELL</name>
                <address>
                    <ns2:street1>35 GATEHOUSE DRIVE, A2</ns2:street1>
                    <ns2:city>WALTHAM,</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02451</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>04/17/2023</saleDate>
            <amountOfSecuritiesSold>1248</amountOfSecuritiesSold>
            <grossProceeds>38166.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/17/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/30/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Robert Edward Farrell Jr.</signature>
        </noticeSignature>
    </formData>
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144
0001592280
XXXXXXXX
LIVE
0001679363
MORPHIC HOLDING, INC.
001-38940
35 GATEHOUSE DRIVE, A2
WALTHAM,
MA
02451
(781) 996-0955
ROBERT FARRELL
Officer
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
20000
850002.00
39534138
04/17/2023
NASD
COMMON
12/05/2018
RSU
Issuer
N
10000
12/05/2018
NONE
COMMON
11/03/2021
Exercised Shares
Issuer
N
10000
11/03/2021
Cash
N
ROBERT FARRELL
35 GATEHOUSE DRIVE, A2
WALTHAM,
MA
02451
COMMON
04/17/2023
1248
38166.00
04/17/2023
12/30/2022
/s/ Robert Edward Farrell Jr.