<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001738144</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001042074</issuerCik>
            <issuerName>CYMABAY THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-36500</secFileNumber>
            <issuerAddress>
                <ns2:street1>7575 Gateway Blvd, Suite 110</ns2:street1>
                <ns2:city>Newark</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94560</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(510) 293-8800</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JANET DORLING</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>7000</noOfUnitsSold>
            <aggregateMarketValue>106699.60</aggregateMarketValue>
            <noOfUnitsOutstanding>113403353</noOfUnitsOutstanding>
            <approxSaleDate>11/10/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/10/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7000</amountOfSecuritiesAcquired>
            <paymentDate>11/10/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>Sales that were executed on November 10, 2023 are being reported on this Form 144 filed on November 13, 2023 given the EDGAR system was not accepting filings on November 10 in observance of the federal holiday.</remarks>
        <noticeSignature>
            <noticeDate>11/13/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/09/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Janet Dorling</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 3553}]
144
0001738144
XXXXXXXX
LIVE
0001042074
CYMABAY THERAPEUTICS, INC.
001-36500
7575 Gateway Blvd, Suite 110
Newark
CA
94560
(510) 293-8800
JANET DORLING
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
7000
106699.60
113403353
11/10/2023
NASDAQ
Common
11/10/2023
Stock Option Exercise
Issuer
N
7000
11/10/2023
Cash
Y
Sales that were executed on November 10, 2023 are being reported on this Form 144 filed on November 13, 2023 given the EDGAR system was not accepting filings on November 10 in observance of the federal holiday.
11/13/2023
08/09/2023
/s/ Janet Dorling