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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerName>23andMe Holding Co.</issuerName>
            <secFileNumber>001-39587</secFileNumber>
            <issuerAddress>
                <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
                <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 938-6300</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KATHY L HIBBS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Former Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>192288</noOfUnitsSold>
            <aggregateMarketValue>79088.05</aggregateMarketValue>
            <noOfUnitsOutstanding>323542807</noOfUnitsOutstanding>
            <approxSaleDate>06/06/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>06/05/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>28561</amountOfSecuritiesAcquired>
            <paymentDate>06/05/2023</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>08/20/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>8753</amountOfSecuritiesAcquired>
            <paymentDate>08/20/2023</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>02/28/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Shares Purchased through Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2835</amountOfSecuritiesAcquired>
            <paymentDate>02/28/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>05/20/2022</acquiredDate>
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            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3080</amountOfSecuritiesAcquired>
            <paymentDate>05/20/2022</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>05/20/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>8753</amountOfSecuritiesAcquired>
            <paymentDate>05/20/2023</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>02/20/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7923</amountOfSecuritiesAcquired>
            <paymentDate>02/20/2023</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>01/06/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>58800</amountOfSecuritiesAcquired>
            <paymentDate>01/06/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>08/31/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Shares Purchased through Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>6472</amountOfSecuritiesAcquired>
            <paymentDate>08/31/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>11/20/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>8753</amountOfSecuritiesAcquired>
            <paymentDate>11/20/2023</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>02/20/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7897</amountOfSecuritiesAcquired>
            <paymentDate>02/20/2024</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>02/20/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>8382</amountOfSecuritiesAcquired>
            <paymentDate>02/20/2024</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>common</securitiesClassTitle>
            <acquiredDate>02/24/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>42079</amountOfSecuritiesAcquired>
            <paymentDate>02/24/2024</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Kathy Hibbs</name>
                <address>
                    <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>05/02/2024</saleDate>
            <amountOfSecuritiesSold>38551</amountOfSecuritiesSold>
            <grossProceeds>18565.19</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Kathy Hibbs</name>
                <address>
                    <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>04/18/2024</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>17688.04</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Kathy Hibbs</name>
                <address>
                    <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>04/04/2024</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>18793.01</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Kathy Hibbs</name>
                <address>
                    <ns2:street1>349 OYSTER POINT BOULEVARD</ns2:street1>
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                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
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            </sellerDetails>
            <securitiesClassTitle>common</securitiesClassTitle>
            <saleDate>03/21/2024</saleDate>
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            <grossProceeds>17439.98</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Kathy Hibbs</name>
                <address>
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                    <ns2:zipCode>94080</ns2:zipCode>
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            <saleDate>03/07/2024</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>19913.01</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/06/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Kathy L Hibbs</signature>
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144
0001267487
XXXXXXXX
LIVE
0001804591
23andMe Holding Co.
001-39587
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
(650) 938-6300
KATHY L HIBBS
Former Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
192288
79088.05
323542807
06/06/2024
NASDAQ
common
06/05/2023
Restricted stock vesting under a registered plan
Issuer
N
28561
06/05/2023
Services Rendered
common
08/20/2023
Restricted stock vesting under a registered plan
Issuer
N
8753
08/20/2023
Services Rendered
common
02/28/2023
Shares Purchased through Employee Stock Purchase Plan
Issuer
N
2835
02/28/2023
Cash
common
05/20/2022
Restricted stock vesting under a registered plan
Issuer
N
3080
05/20/2022
Services Rendered
common
05/20/2023
Restricted stock vesting under a registered plan
Issuer
N
8753
05/20/2023
Services Rendered
common
02/20/2023
Restricted stock vesting under a registered plan
Issuer
N
7923
02/20/2023
Services Rendered
common
01/06/2022
Exercise of options under a registered plan
Issuer
N
58800
01/06/2022
Cash
common
08/31/2023
Shares Purchased through Employee Stock Purchase Plan
Issuer
N
6472
08/31/2023
Cash
common
11/20/2023
Restricted stock vesting under a registered plan
Issuer
N
8753
11/20/2023
Services Rendered
common
02/20/2024
Restricted stock vesting under a registered plan
Issuer
N
7897
02/20/2024
Services Rendered
common
02/20/2024
Restricted stock vesting under a registered plan
Issuer
N
8382
02/20/2024
Services Rendered
common
02/24/2024
Restricted stock vesting under a registered plan
Issuer
N
42079
02/24/2024
Services Rendered
N
Kathy Hibbs
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
common
05/02/2024
38551
18565.19
Kathy Hibbs
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
common
04/18/2024
38548
17688.04
Kathy Hibbs
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
common
04/04/2024
38548
18793.01
Kathy Hibbs
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
common
03/21/2024
38548
17439.98
Kathy Hibbs
349 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
common
03/07/2024
38548
19913.01
06/06/2024
/s/ Kathy L Hibbs