<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001597158</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001376339</issuerCik>
      <issuerName>MIMEDX GROUP, INC.</issuerName>
      <secFileNumber>001-35887</secFileNumber>
      <issuerAddress>
        <com:street1>1775 W OAK COMMONS COURT, NE</com:street1>
        <com:city>MARIETTA</com:city>
        <com:stateOrCountry>GA</com:stateOrCountry>
        <com:zipCode>30062</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(770) 651-9100</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Stein Robert Benjamin</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>FIDELITY BROKERAGE SERVICES, LLC</name>
        <address>
          <com:street1>900 SALEM STREET</com:street1>
          <com:city>SMITHFIELD</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>5987</noOfUnitsSold>
      <aggregateMarketValue>22415.93</aggregateMarketValue>
      <noOfUnitsOutstanding>114083096</noOfUnitsOutstanding>
      <approxSaleDate>04/25/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>04/21/2023</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK VESTING</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>5987</amountOfSecuritiesAcquired>
      <paymentDate>04/21/2023</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>ROBERT STEIN</name>
        <address>
          <com:street1>1775 West Oak Commons Court, NE</com:street1>
          <com:city>MARIETTA</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30062</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>04/11/2023</saleDate>
      <amountOfSecuritiesSold>5996</amountOfSecuritiesSold>
      <grossProceeds>19852.76</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>ROBERT STEIN</name>
        <address>
          <com:street1>1775 West Oak Commons Court, NE</com:street1>
          <com:city>MARIETTA</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30062</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>03/07/2023</saleDate>
      <amountOfSecuritiesSold>12355</amountOfSecuritiesSold>
      <grossProceeds>52442.03</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>04/25/2023</noticeDate>
      <signature>/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Robert Stein</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4033}]
144
0001597158
XXXXXXXX
LIVE
0001376339
MIMEDX GROUP, INC.
001-35887
1775 W OAK COMMONS COURT, NE
MARIETTA
GA
30062
(770) 651-9100
Stein Robert Benjamin
Officer
COMMON
FIDELITY BROKERAGE SERVICES, LLC
900 SALEM STREET
SMITHFIELD
RI
02917
5987
22415.93
114083096
04/25/2023
NASDAQ
COMMON
04/21/2023
RESTRICTED STOCK VESTING
ISSUER
N
5987
04/21/2023
COMPENSATION
N
ROBERT STEIN
1775 West Oak Commons Court, NE
MARIETTA
GA
30062
COMMON
04/11/2023
5996
19852.76
ROBERT STEIN
1775 West Oak Commons Court, NE
MARIETTA
GA
30062
COMMON
03/07/2023
12355
52442.03
04/25/2023
/s/ Daniel Tucci, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Robert Stein