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            <filer>
                <filerCredentials>
                    <cik>0001692954</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0000939767</issuerCik>
            <issuerName>EXELIXIS, INC.</issuerName>
            <secFileNumber>000-30235</secFileNumber>
            <issuerAddress>
                <ns2:street1>1851 Harbor Bay Parkway</ns2:street1>
                <ns2:city>Alameda</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94502</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 837-7000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PATRICK JOSEPH HALEY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>14149</noOfUnitsSold>
            <aggregateMarketValue>318397.78</aggregateMarketValue>
            <noOfUnitsOutstanding>310974113</noOfUnitsOutstanding>
            <approxSaleDate>12/12/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>02/15/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>14149</amountOfSecuritiesAcquired>
            <paymentDate>02/15/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>12/12/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/07/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Patrick J Haley</signature>
        </noticeSignature>
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144
0001692954
XXXXXXXX
LIVE
0000939767
EXELIXIS, INC.
000-30235
1851 Harbor Bay Parkway
Alameda
CA
94502
(650) 837-7000
PATRICK JOSEPH HALEY
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
14149
318397.78
310974113
12/12/2023
NASDAQ
COMMON
02/15/2022
Performance Shares
ISSUER
N
14149
02/15/2022
Not Applicable
Y
12/12/2023
08/07/2023
/s/ Patrick J Haley