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          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



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      <issuerCik>0000014272</issuerCik>
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      <secFileNumber>001-01136</secFileNumber>
      <issuerAddress>
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        <com:street2>14 FLOOR</com:street2>
        <com:city>NEW YORK</com:city>
        <com:stateOrCountry>NY</com:stateOrCountry>
        <com:zipCode>10016</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>2125464000</issuerContactPhone>
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      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
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    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
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      </brokerOrMarketmakerDetails>
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      <noOfUnitsOutstanding>2100847138</noOfUnitsOutstanding>
      <approxSaleDate>05/03/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
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      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/30/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
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      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>621</amountOfSecuritiesAcquired>
      <paymentDate>07/30/2021</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
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    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/02/2021</acquiredDate>
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      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4294</amountOfSecuritiesAcquired>
      <paymentDate>12/02/2021</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/31/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>17710</amountOfSecuritiesAcquired>
      <paymentDate>12/31/2021</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/04/2022</acquiredDate>
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      <paymentDate>02/04/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
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    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/01/2022</acquiredDate>
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      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>13047</amountOfSecuritiesAcquired>
      <paymentDate>03/01/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/10/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>8355</amountOfSecuritiesAcquired>
      <paymentDate>03/10/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/16/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4077</amountOfSecuritiesAcquired>
      <paymentDate>03/16/2022</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/03/2023</noticeDate>
      <signature>/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Stephen John Rupert Vessey</signature>
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144
0001677618
XXXXXXXX
LIVE
0000014272
BRISTOL MYERS SQUIBB CO
001-01136
430 E. 29TH STREET
14 FLOOR
NEW YORK
NY
10016
2125464000
VESSEY RUPERT
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
50385
3378940.88
2100847138
05/03/2023
NYSE
Common
07/30/2021
Stock Option Exercise
Issuer
N
621
07/30/2021
Cash
Common
12/02/2021
Restricted Stock Vesting
Issuer
N
4294
12/02/2021
Compensation
Common
12/31/2021
Restricted Stock Vesting
Issuer
N
17710
12/31/2021
Compensation
Common
02/04/2022
Restricted Stock Vesting
Issuer
N
2281
02/04/2022
Compensation
Common
03/01/2022
Restricted Stock Vesting
Issuer
N
13047
03/01/2022
Compensation
Common
03/10/2022
Restricted Stock Vesting
Issuer
N
8355
03/10/2022
Compensation
Common
03/16/2022
Stock Option Exercise
Issuer
N
4077
03/16/2022
Cash
Y
05/03/2023
/s/ Ryan Riviere, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Stephen John Rupert Vessey