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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0000939767</issuerCik>
            <issuerName>EXELIXIS, INC.</issuerName>
            <secFileNumber>000-30235</secFileNumber>
            <issuerAddress>
                <ns2:street1>1851 Harbor Bay Parkway</ns2:street1>
                <ns2:city>Alameda</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94502</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 837-7000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JEFFREY HESSEKIEL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>60000</noOfUnitsSold>
            <aggregateMarketValue>2200230.00</aggregateMarketValue>
            <noOfUnitsOutstanding>285579020</noOfUnitsOutstanding>
            <approxSaleDate>11/29/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/03/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>15276</amountOfSecuritiesAcquired>
            <paymentDate>02/03/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/03/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1563</amountOfSecuritiesAcquired>
            <paymentDate>02/03/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/06/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>14596</amountOfSecuritiesAcquired>
            <paymentDate>09/06/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/15/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7298</amountOfSecuritiesAcquired>
            <paymentDate>08/15/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>08/03/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7298</amountOfSecuritiesAcquired>
            <paymentDate>08/03/2022</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>10/22/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of options under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>13969</amountOfSecuritiesAcquired>
            <paymentDate>10/22/2020</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JEFF HESSEKIEL</name>
                <address>
                    <ns2:street1>1851 Harbor Bay Parkway</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>EXEL</securitiesClassTitle>
            <saleDate>11/01/2024</saleDate>
            <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
            <grossProceeds>1705491.55</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JEFF HESSEKIEL</name>
                <address>
                    <ns2:street1>1851 Harbor Bay Parkway</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>EXEL</securitiesClassTitle>
            <saleDate>10/28/2024</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>709166.70</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JEFF HESSEKIEL</name>
                <address>
                    <ns2:street1>1851 Harbor Bay Parkway</ns2:street1>
                    <ns2:city>Alameda</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94502</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>EXEL</securitiesClassTitle>
            <saleDate>09/23/2024</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>658860.60</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>11/29/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Jeffrey J Hessekiel</signature>
        </noticeSignature>
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144
0001599803
XXXXXXXX
LIVE
0000939767
EXELIXIS, INC.
000-30235
1851 Harbor Bay Parkway
Alameda
CA
94502
(650) 837-7000
JEFFREY HESSEKIEL
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
60000
2200230.00
285579020
11/29/2024
NASDAQ
Common
02/03/2021
Exercise of options under a registered plan
Issuer
N
15276
02/03/2021
Cash
Common
02/03/2021
Exercise of options under a registered plan
Issuer
N
1563
02/03/2021
Cash
Common
09/06/2023
Exercise of options under a registered plan
Issuer
N
14596
09/06/2023
Cash
Common
08/15/2023
Exercise of options under a registered plan
Issuer
N
7298
08/15/2023
Cash
Common
08/03/2022
Exercise of options under a registered plan
Issuer
N
7298
08/03/2022
Cash
Common
10/22/2020
Exercise of options under a registered plan
Issuer
N
13969
10/22/2020
Cash
N
JEFF HESSEKIEL
1851 Harbor Bay Parkway
Alameda
CA
94502
EXEL
11/01/2024
50000
1705491.55
JEFF HESSEKIEL
1851 Harbor Bay Parkway
Alameda
CA
94502
EXEL
10/28/2024
25000
709166.70
JEFF HESSEKIEL
1851 Harbor Bay Parkway
Alameda
CA
94502
EXEL
09/23/2024
25000
658860.60
11/29/2024
/s/ Jeffrey J Hessekiel