<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001631803</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001043219</issuerCik>
            <issuerName>ANNALY CAPITAL MANAGEMENT, INC.</issuerName>
            <secFileNumber>001-13447</secFileNumber>
            <issuerAddress>
                <ns2:street1>1211 Avenue of the Americas</ns2:street1>
                <ns2:city>New York</ns2:city>
                <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                <ns2:zipCode>10036</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>212-696-0100</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEVEN F CAMPBELL </nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>44374</noOfUnitsSold>
            <aggregateMarketValue>864849.26</aggregateMarketValue>
            <noOfUnitsOutstanding>605089071</noOfUnitsOutstanding>
            <approxSaleDate>05/13/2025</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/22/2017</acquiredDate>
            <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>12500</amountOfSecuritiesAcquired>
            <paymentDate>02/22/2017</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/31/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>29097</amountOfSecuritiesAcquired>
            <paymentDate>01/31/2021</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/15/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2777</amountOfSecuritiesAcquired>
            <paymentDate>02/15/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon open market purchases during the period of 02/22/2017 through 05/23/2019.
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 01/31/2021 through 02/15/2024.
</remarks>
        <noticeSignature>
            <noticeDate>05/13/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/05/2025</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Steven Francis Campbell</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001631803
XXXXXXXX
LIVE
0001043219
ANNALY CAPITAL MANAGEMENT, INC.
001-13447
1211 Avenue of the Americas
New York
NY
10036
212-696-0100
STEVEN F CAMPBELL
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
44374
864849.26
605089071
05/13/2025
NYSE
Common
02/22/2017
Open Market Purchase
Issuer
N
12500
02/22/2017
Cash
Common
01/31/2021
Restricted Stock Units
Issuer
N
29097
01/31/2021
N/A
Common
02/15/2024
Performance Stock Units
Issuer
N
2777
02/15/2024
N/A
Y
The securities to be sold were acquired upon open market purchases during the period of 02/22/2017 through 05/23/2019.
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 01/31/2021 through 02/15/2024.
05/13/2025
02/05/2025
/s/ Steven Francis Campbell