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                    <cik>0002007050</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
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            <issuerName>SOPHIA GENETICS SA</issuerName>
            <secFileNumber>001-40627</secFileNumber>
            <issuerAddress>
                <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                <ns2:city>Rolle</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41216941060</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JURGI CAMBLONG</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
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            <brokerOrMarketmakerDetails>
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                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
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            <aggregateMarketValue>127679.60</aggregateMarketValue>
            <noOfUnitsOutstanding>66687085</noOfUnitsOutstanding>
            <approxSaleDate>05/19/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
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            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>43135</amountOfSecuritiesAcquired>
            <paymentDate>05/18/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/23/2025</saleDate>
            <amountOfSecuritiesSold>769</amountOfSecuritiesSold>
            <grossProceeds>2329.53</grossProceeds>
        </securitiesSoldInPast3Months>
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                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/21/2025</saleDate>
            <amountOfSecuritiesSold>4486</amountOfSecuritiesSold>
            <grossProceeds>12192.50</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
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                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/17/2025</saleDate>
            <amountOfSecuritiesSold>7507</amountOfSecuritiesSold>
            <grossProceeds>20745.59</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/16/2025</saleDate>
            <amountOfSecuritiesSold>4300</amountOfSecuritiesSold>
            <grossProceeds>12048.17</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/15/2025</saleDate>
            <amountOfSecuritiesSold>3244</amountOfSecuritiesSold>
            <grossProceeds>9172.73</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/14/2025</saleDate>
            <amountOfSecuritiesSold>5256</amountOfSecuritiesSold>
            <grossProceeds>15321.77</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/11/2025</saleDate>
            <amountOfSecuritiesSold>9011</amountOfSecuritiesSold>
            <grossProceeds>25517.35</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/10/2025</saleDate>
            <amountOfSecuritiesSold>1482</amountOfSecuritiesSold>
            <grossProceeds>4122.03</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/09/2025</saleDate>
            <amountOfSecuritiesSold>12323</amountOfSecuritiesSold>
            <grossProceeds>34842.05</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/08/2025</saleDate>
            <amountOfSecuritiesSold>1900</amountOfSecuritiesSold>
            <grossProceeds>5238.49</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/07/2025</saleDate>
            <amountOfSecuritiesSold>1837</amountOfSecuritiesSold>
            <grossProceeds>4912.51</grossProceeds>
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        <securitiesSoldInPast3Months>
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                <name>10b5-1 Sales for JURGI CAMBLONG</name>
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                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
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            <amountOfSecuritiesSold>1674</amountOfSecuritiesSold>
            <grossProceeds>4608.35</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
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            <grossProceeds>2049.57</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/24/2025</saleDate>
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            <grossProceeds>2434.35</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/19/2025</saleDate>
            <amountOfSecuritiesSold>4487</amountOfSecuritiesSold>
            <grossProceeds>13692.53</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/24/2025</saleDate>
            <amountOfSecuritiesSold>769</amountOfSecuritiesSold>
            <grossProceeds>3024.09</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 05/18/2025 through 07/22/2025.
</remarks>
        <noticeSignature>
            <noticeDate>05/19/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/09/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jurgi Camblong</signature>
        </noticeSignature>
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[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 14796}]
144
0002007050
XXXXXXXX
LIVE
0001840706
SOPHIA GENETICS SA
001-40627
La Piece 12 ch-1180
Rolle
V8
00000
41216941060
JURGI CAMBLONG
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
43135
127679.60
66687085
05/19/2025
NASDAQ
Common
05/18/2025
Restricted Stock Units
Issuer
N
43135
05/18/2025
N/A
N
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/23/2025
769
2329.53
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/21/2025
4486
12192.50
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/17/2025
7507
20745.59
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/16/2025
4300
12048.17
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/15/2025
3244
9172.73
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/14/2025
5256
15321.77
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/11/2025
9011
25517.35
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/10/2025
1482
4122.03
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/09/2025
12323
34842.05
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/08/2025
1900
5238.49
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/07/2025
1837
4912.51
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/04/2025
1674
4608.35
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
04/03/2025
671
2049.57
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
03/24/2025
769
2434.35
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
03/19/2025
4487
13692.53
10b5-1 Sales for JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
02/24/2025
769
3024.09
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 05/18/2025 through 07/22/2025.
05/19/2025
09/09/2024
/s/ Jurgi Camblong