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      <issuerCik>0001554859</issuerCik>
      <issuerName>Semler Scientific, Inc.</issuerName>
      <secFileNumber>001-36305</secFileNumber>
      <issuerAddress>
        <com:street1>2340-2348 WALSH AVENUE, SUITE 2344</com:street1>
        <com:street2>Suite 2344</com:street2>
        <com:city>SANTA CLARA</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>95051</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>877-774-4211</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Chang William H</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co. Inc.</name>
        <address>
          <com:street1>3000 schwab way</com:street1>
          <com:city>westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>10000</noOfUnitsSold>
      <aggregateMarketValue>617500.00</aggregateMarketValue>
      <noOfUnitsOutstanding>7266242</noOfUnitsOutstanding>
      <approxSaleDate>12/09/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>common</securitiesClassTitle>
      <acquiredDate>09/30/2012</acquiredDate>
      <natureOfAcquisitionTransaction>Direct Purchase from Company</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Semler Scientific Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
      <paymentDate>09/30/2012</paymentDate>
      <natureOfPayment>cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Sale executed in the Chang Family Trust dtd 10/23/2006</remarks>
    <noticeSignature>
      <noticeDate>12/09/2024</noticeDate>
      <signature>William Chang</signature>
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144
0001594408
XXXXXXXX
LIVE
0001554859
Semler Scientific, Inc.
001-36305
2340-2348 WALSH AVENUE, SUITE 2344
Suite 2344
SANTA CLARA
CA
95051
877-774-4211
Chang William H
Director
common
Charles Schwab & Co. Inc.
3000 schwab way
westlake
TX
76262
10000
617500.00
7266242
12/09/2024
NASDAQ
common
09/30/2012
Direct Purchase from Company
Semler Scientific Inc.
N
10000
09/30/2012
cash
Y
Sale executed in the Chang Family Trust dtd 10/23/2006
12/09/2024
William Chang