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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001711968</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
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        <issuerInfo>
            <issuerCik>0001604821</issuerCik>
            <issuerName>NATERA, INC.</issuerName>
            <secFileNumber>001-37478</secFileNumber>
            <issuerAddress>
                <ns2:street1>13011 McCallen Pass</ns2:street1>
                <ns2:street2>Building A Suite 100</ns2:street2>
                <ns2:city>Austin</ns2:city>
                <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                <ns2:zipCode>78753</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 980-9190</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEVEN L CHAPMAN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>37500</noOfUnitsSold>
            <aggregateMarketValue>4053806.25</aggregateMarketValue>
            <noOfUnitsOutstanding>122802694</noOfUnitsOutstanding>
            <approxSaleDate>07/01/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>06/30/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>37500</amountOfSecuritiesAcquired>
            <paymentDate>06/30/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/17/2024</saleDate>
            <amountOfSecuritiesSold>6105</amountOfSecuritiesSold>
            <grossProceeds>681371.11</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/15/2024</saleDate>
            <amountOfSecuritiesSold>6779</amountOfSecuritiesSold>
            <grossProceeds>725910.91</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/29/2024</saleDate>
            <amountOfSecuritiesSold>4084</amountOfSecuritiesSold>
            <grossProceeds>380378.45</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/23/2024</saleDate>
            <amountOfSecuritiesSold>2552</amountOfSecuritiesSold>
            <grossProceeds>233199.46</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN L CHAPMAN</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/15/2024</saleDate>
            <amountOfSecuritiesSold>6816</amountOfSecuritiesSold>
            <grossProceeds>634797.25</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>07/01/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/11/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Steven Leonard Chapman</signature>
        </noticeSignature>
    </formData>
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[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 7244}]
144
0001711968
XXXXXXXX
LIVE
0001604821
NATERA, INC.
001-37478
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
(650) 980-9190
STEVEN L CHAPMAN
Officer
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
37500
4053806.25
122802694
07/01/2024
NASDAQ
COMMON
06/30/2024
Restricted Stock
ISSUER
N
37500
06/30/2024
Not Applicable
N
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
06/17/2024
6105
681371.11
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
05/15/2024
6779
725910.91
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
04/29/2024
4084
380378.45
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
04/23/2024
2552
233199.46
STEVEN L CHAPMAN
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
04/15/2024
6816
634797.25
07/01/2024
12/11/2023
/s/ Steven Leonard Chapman