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      <secFileNumber>001-38276</secFileNumber>
      <issuerAddress>
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        <com:city>WALTHAM</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02451</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>617-977-5700</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Deschatelets Pascal</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>12000</noOfUnitsSold>
      <aggregateMarketValue>938520.00</aggregateMarketValue>
      <noOfUnitsOutstanding>111290699</noOfUnitsOutstanding>
      <approxSaleDate>04/10/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>04/10/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted - 12/05/2013</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>12000</amountOfSecuritiesAcquired>
      <paymentDate>04/10/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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        <name>Pascal Deschatelets</name>
        <address>
          <com:street1>100 Fifth Avenue</com:street1>
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          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
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      <securitiesClassTitle>Common</securitiesClassTitle>
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      <amountOfSecuritiesSold>12000</amountOfSecuritiesSold>
      <grossProceeds>653400.00</grossProceeds>
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      <sellerDetails>
        <name>Pascal Deschatelets</name>
        <address>
          <com:street1>100 Fifth Avenue</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
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      <amountOfSecuritiesSold>12000</amountOfSecuritiesSold>
      <grossProceeds>765480.00</grossProceeds>
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    <noticeSignature>
      <noticeDate>04/10/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>05/09/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Pascal Deschatelets</signature>
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144
0001657720
XXXXXXXX
LIVE
0001492422
Apellis Pharmaceuticals, Inc.
001-38276
100 FIFTH AVENUE
WALTHAM
MA
02451
617-977-5700
Deschatelets Pascal
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
12000
938520.00
111290699
04/10/2023
NASDAQ
Common
04/10/2023
Option Granted - 12/05/2013
Issuer
N
12000
04/10/2023
Cash
N
Pascal Deschatelets
100 Fifth Avenue
Waltham
MA
02451
Common
02/08/2023
12000
653400.00
Pascal Deschatelets
100 Fifth Avenue
Waltham
MA
02451
Common
03/08/2023
12000
765480.00
04/10/2023
05/09/2022
/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Pascal Deschatelets