<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001330269</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001035267</issuerCik>
            <issuerName>INTUITIVE SURGICAL, INC.</issuerName>
            <secFileNumber>000-30713</secFileNumber>
            <issuerAddress>
                <ns2:street1>1020 KIFER ROAD</ns2:street1>
                <ns2:city>SUNNYVALE</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94086</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(408) 523-2100</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JAMIE E SAMATH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>270</noOfUnitsSold>
            <aggregateMarketValue>145841.85</aggregateMarketValue>
            <noOfUnitsOutstanding>356179445</noOfUnitsOutstanding>
            <approxSaleDate>12/10/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/10/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>270</amountOfSecuritiesAcquired>
            <paymentDate>12/10/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JAMIE E SAMATH</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/29/2024</saleDate>
            <amountOfSecuritiesSold>188</amountOfSecuritiesSold>
            <grossProceeds>101332.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JAMIE E SAMATH</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/26/2024</saleDate>
            <amountOfSecuritiesSold>108</amountOfSecuritiesSold>
            <grossProceeds>58542.48</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JAMIE E SAMATH</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/11/2024</saleDate>
            <amountOfSecuritiesSold>269</amountOfSecuritiesSold>
            <grossProceeds>145230.41</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JAMIE E SAMATH</name>
                <address>
                    <ns2:street1>1020 KIFER ROAD</ns2:street1>
                    <ns2:city>SUNNYVALE</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94086</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/08/2024</saleDate>
            <amountOfSecuritiesSold>22903</amountOfSecuritiesSold>
            <grossProceeds>12024075.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>12/10/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/06/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jamie Elmo Samath</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 6059}]
144
0001330269
XXXXXXXX
LIVE
0001035267
INTUITIVE SURGICAL, INC.
000-30713
1020 KIFER ROAD
SUNNYVALE
CA
94086
(408) 523-2100
JAMIE E SAMATH
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
270
145841.85
356179445
12/10/2024
NASDAQ
Common
12/10/2024
Stock Option Exercise
ISSUER
N
270
12/10/2024
Cash
N
JAMIE E SAMATH
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
11/29/2024
188
101332.00
JAMIE E SAMATH
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
11/26/2024
108
58542.48
JAMIE E SAMATH
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
11/11/2024
269
145230.41
JAMIE E SAMATH
1020 KIFER ROAD
SUNNYVALE
CA
94086
Common
11/08/2024
22903
12024075.00
12/10/2024
05/06/2024
/s/ Jamie Elmo Samath