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            <filer>
                <filerCredentials>
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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001674416</issuerCik>
            <issuerName>CRISPR THERAPEUTICS AG</issuerName>
            <secFileNumber>001-37923</secFileNumber>
            <issuerAddress>
                <ns2:street1>Baarerstrasse 14</ns2:street1>
                <ns2:city>Zug</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>6300</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41 (0)41 561 32 77</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SAMARTH KULKARNI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>25000</noOfUnitsSold>
            <aggregateMarketValue>1620845.00</aggregateMarketValue>
            <noOfUnitsOutstanding>78935098</noOfUnitsOutstanding>
            <approxSaleDate>05/30/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/30/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>25000</amountOfSecuritiesAcquired>
            <paymentDate>05/30/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <name>SAMARTH KULKARNI</name>
                <address>
                    <ns2:street1>Baarerstrasse 14</ns2:street1>
                    <ns2:city>Zug</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>6300</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/25/2023</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>1266635.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SAMARTH KULKARNI</name>
                <address>
                    <ns2:street1>Baarerstrasse 14</ns2:street1>
                    <ns2:city>Zug</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>6300</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/29/2023</saleDate>
            <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
            <grossProceeds>1111503.00</grossProceeds>
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            <sellerDetails>
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                    <ns2:city>Zug</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>6300</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/13/2023</saleDate>
            <amountOfSecuritiesSold>9444</amountOfSecuritiesSold>
            <grossProceeds>422152.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/30/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>05/26/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Samarth Kulkarni</signature>
        </noticeSignature>
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144
0001682019
XXXXXXXX
LIVE
0001674416
CRISPR THERAPEUTICS AG
001-37923
Baarerstrasse 14
Zug
V8
6300
41 (0)41 561 32 77
SAMARTH KULKARNI
Officer
Director
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
25000
1620845.00
78935098
05/30/2023
NASD
Common
05/30/2023
Stock Option Exercise
Issuer
N
25000
05/30/2023
Cash
N
SAMARTH KULKARNI
Baarerstrasse 14
Zug
V8
6300
Common
04/25/2023
25000
1266635.00
SAMARTH KULKARNI
Baarerstrasse 14
Zug
V8
6300
Common
03/29/2023
25000
1111503.00
SAMARTH KULKARNI
Baarerstrasse 14
Zug
V8
6300
Common
03/13/2023
9444
422152.00
05/30/2023
05/26/2022
/s/ Samarth Kulkarni