<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001559422</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001559053</issuerCik>
            <issuerName>PROTHENA CORPORATION PLC</issuerName>
            <secFileNumber>001-35676</secFileNumber>
            <issuerAddress>
                <ns2:street1>77 Sir John Rogersons Quay, Block C Gran</ns2:street1>
                <ns2:street2>d Canal Docklands</ns2:street2>
                <ns2:city>Dublin 2</ns2:city>
                <ns2:stateOrCountry>L2</ns2:stateOrCountry>
                <ns2:zipCode>D02 VK60</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>011-353-1-236-2500</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KARIN WALKER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>5000</noOfUnitsSold>
            <aggregateMarketValue>344494.00</aggregateMarketValue>
            <noOfUnitsOutstanding>52751775</noOfUnitsOutstanding>
            <approxSaleDate>06/20/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/20/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
            <paymentDate>06/20/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>KARIN WALKER</name>
                <address>
                    <ns2:street1>77 Sir John Rogersons Quay, Block C Gran</ns2:street1>
                    <ns2:street2>d Canal Docklands</ns2:street2>
                    <ns2:city>Dublin 2</ns2:city>
                    <ns2:stateOrCountry>L2</ns2:stateOrCountry>
                    <ns2:zipCode>D02 VK60</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/19/2023</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>369978.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>KARIN WALKER</name>
                <address>
                    <ns2:street1>77 Sir John Rogersons Quay, Block C Gran</ns2:street1>
                    <ns2:street2>d Canal Docklands</ns2:street2>
                    <ns2:city>Dublin 2</ns2:city>
                    <ns2:stateOrCountry>L2</ns2:stateOrCountry>
                    <ns2:zipCode>D02 VK60</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/19/2023</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>264479.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/20/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/22/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Karin Lorraine Walker</signature>
        </noticeSignature>
    </formData>
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144
0001559422
XXXXXXXX
LIVE
0001559053
PROTHENA CORPORATION PLC
001-35676
77 Sir John Rogersons Quay, Block C Gran
d Canal Docklands
Dublin 2
L2
D02 VK60
011-353-1-236-2500
KARIN WALKER
Officer
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
5000
344494.00
52751775
06/20/2023
NASD
Common
06/20/2023
Stock Option Exercise
Issuer
N
5000
06/20/2023
Cash
N
KARIN WALKER
77 Sir John Rogersons Quay, Block C Gran
d Canal Docklands
Dublin 2
L2
D02 VK60
Common
05/19/2023
5000
369978.00
KARIN WALKER
77 Sir John Rogersons Quay, Block C Gran
d Canal Docklands
Dublin 2
L2
D02 VK60
Common
04/19/2023
5000
264479.50
06/20/2023
09/22/2022
/s/ Karin Lorraine Walker