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    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001453096</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001324404</issuerCik>
      <issuerName>CF Industries Holdings, Inc.</issuerName>
      <secFileNumber>001-32597</secFileNumber>
      <issuerAddress>
        <com:street1>2375 WATERVIEW DRIVE</com:street1>
        <com:city>NORTHBROOK</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60062</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(847) 405-2400</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Frost Bert A</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>21003</noOfUnitsSold>
      <aggregateMarketValue>2047643.00</aggregateMarketValue>
      <noOfUnitsOutstanding>162010025</noOfUnitsOutstanding>
      <approxSaleDate>06/13/2025</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/02/2023</acquiredDate>
      <natureOfAcquisitionTransaction>RSU / PSU - See Remarks</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CF INDUSTRIES HOLDINGS, INC.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>21003</amountOfSecuritiesAcquired>
      <paymentDate>01/02/2023</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Shares on this filing were acquired and paid for 01/02/2023 through 01/04/2025 and may be sold over various dates.</remarks>
    <noticeSignature>
      <noticeDate>06/13/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>03/06/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>BERT A FROST</signature>
    </noticeSignature>
  </formData>
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144
0001453096
XXXXXXXX
LIVE
0001324404
CF Industries Holdings, Inc.
001-32597
2375 WATERVIEW DRIVE
NORTHBROOK
IL
60062
(847) 405-2400
Frost Bert A
Officer
Common
Charles Schwab & Co., Inc.
3000 Schwab Way
Westlake
TX
76262
21003
2047643.00
162010025
06/13/2025
NYSE
Common
01/02/2023
RSU / PSU - See Remarks
CF INDUSTRIES HOLDINGS, INC.
N
21003
01/02/2023
Equity Compensation
Y
Shares on this filing were acquired and paid for 01/02/2023 through 01/04/2025 and may be sold over various dates.
06/13/2025
03/06/2025
BERT A FROST