<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001852129</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001061983</issuerCik>
            <issuerName>CYTOKINETICS, INCORPORATED</issuerName>
            <secFileNumber>000-50633</secFileNumber>
            <issuerAddress>
                <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6506243000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ANDREW CALLOS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>21000</noOfUnitsSold>
            <aggregateMarketValue>932400.00</aggregateMarketValue>
            <noOfUnitsOutstanding>118410689</noOfUnitsOutstanding>
            <approxSaleDate>03/14/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/14/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>21000</amountOfSecuritiesAcquired>
            <paymentDate>03/14/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ANDREW CALLOS</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/13/2025</saleDate>
            <amountOfSecuritiesSold>26771</amountOfSecuritiesSold>
            <grossProceeds>1167830.32</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ANDREW CALLOS</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/06/2025</saleDate>
            <amountOfSecuritiesSold>3341</amountOfSecuritiesSold>
            <grossProceeds>144565.07</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ANDREW CALLOS</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/03/2025</saleDate>
            <amountOfSecuritiesSold>1114</amountOfSecuritiesSold>
            <grossProceeds>47768.32</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>03/14/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/12/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Andrew Callos</signature>
        </noticeSignature>
    </formData>
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144
0001852129
XXXXXXXX
LIVE
0001061983
CYTOKINETICS, INCORPORATED
000-50633
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
6506243000
ANDREW CALLOS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
21000
932400.00
118410689
03/14/2025
NASDAQ
Common
03/14/2025
Exercise of Stock Options
Issuer
N
21000
03/14/2025
Cash
N
10b5-1 Sales for ANDREW CALLOS
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
03/13/2025
26771
1167830.32
ANDREW CALLOS
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
03/06/2025
3341
144565.07
ANDREW CALLOS
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
03/03/2025
1114
47768.32
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
03/14/2025
12/12/2024
/s/ Andrew Callos