<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001881190</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001439222</issuerCik>
            <issuerName>AGIOS PHARMACEUTICALS, INC.</issuerName>
            <secFileNumber>001-36014</secFileNumber>
            <issuerAddress>
                <ns2:street1>88 Sidney St.</ns2:street1>
                <ns2:city>Cambridge</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02139</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>617-649-8600</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SARAH GHEUENS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>11914</noOfUnitsSold>
            <aggregateMarketValue>452631.92</aggregateMarketValue>
            <noOfUnitsOutstanding>57915199</noOfUnitsOutstanding>
            <approxSaleDate>07/09/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>07/09/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>11914</amountOfSecuritiesAcquired>
            <paymentDate>07/09/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SARAH GHEUENS</name>
                <address>
                    <ns2:street1>88 Sidney St.</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02139</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/01/2025</saleDate>
            <amountOfSecuritiesSold>4091</amountOfSecuritiesSold>
            <grossProceeds>139787.42</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SARAH GHEUENS</name>
                <address>
                    <ns2:street1>88 Sidney St.</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02139</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/24/2025</saleDate>
            <amountOfSecuritiesSold>2909</amountOfSecuritiesSold>
            <grossProceeds>97553.90</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>07/09/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/25/2025</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Sarah Gheuens</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 4672}]
144
0001881190
XXXXXXXX
LIVE
0001439222
AGIOS PHARMACEUTICALS, INC.
001-36014
88 Sidney St.
Cambridge
MA
02139
617-649-8600
SARAH GHEUENS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
11914
452631.92
57915199
07/09/2025
NASDAQ
Common
07/09/2025
Stock Option Exercise
Issuer
N
11914
07/09/2025
Cash
N
SARAH GHEUENS
88 Sidney St.
Cambridge
MA
02139
Common
07/01/2025
4091
139787.42
SARAH GHEUENS
88 Sidney St.
Cambridge
MA
02139
Common
06/24/2025
2909
97553.90
07/09/2025
02/25/2025
/s/ Sarah Gheuens