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            <filer>
                <filerCredentials>
                    <cik>0001963879</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
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    <formData>
        <issuerInfo>
            <issuerCik>0001745999</issuerCik>
            <issuerName>BEAM THERAPEUTICS INC.</issuerName>
            <secFileNumber>001-39208</secFileNumber>
            <issuerAddress>
                <ns2:street1>238 Main Street</ns2:street1>
                <ns2:city>Cambridge</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02142</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(857) 327-8775</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>AMY SIMON</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>20997</noOfUnitsSold>
            <aggregateMarketValue>372293.61</aggregateMarketValue>
            <noOfUnitsOutstanding>82805627</noOfUnitsOutstanding>
            <approxSaleDate>04/02/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/31/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>20997</amountOfSecuritiesAcquired>
            <paymentDate>03/31/2025</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>AMY SIMON</name>
                <address>
                    <ns2:street1>238 Main Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02142</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/01/2025</saleDate>
            <amountOfSecuritiesSold>9566</amountOfSecuritiesSold>
            <grossProceeds>175526.69</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/02/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/07/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Amy Simon</signature>
        </noticeSignature>
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144
0001963879
XXXXXXXX
LIVE
0001745999
BEAM THERAPEUTICS INC.
001-39208
238 Main Street
Cambridge
MA
02142
(857) 327-8775
AMY SIMON
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
20997
372293.61
82805627
04/02/2025
NASDAQ
Common
03/31/2025
Restricted Stock
ISSUER
N
20997
03/31/2025
Not Applicable
N
AMY SIMON
238 Main Street
Cambridge
MA
02142
Common
04/01/2025
9566
175526.69
04/02/2025
11/07/2024
/s/ Amy Simon