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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001468308</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001211583</issuerCik>
            <issuerName>FENNEC PHARMACEUTICALS INC.</issuerName>
            <secFileNumber>001-32295</secFileNumber>
            <issuerAddress>
                <ns2:street1>PO BOX 13628, 68 TW ALEXANDER DRIVE</ns2:street1>
                <ns2:city>Research Triangle Park</ns2:city>
                <ns2:stateOrCountry>NC</ns2:stateOrCountry>
                <ns2:zipCode>27709</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(919) 636-4530</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROBERT ANDRADE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>7500</noOfUnitsSold>
            <aggregateMarketValue>66118.50</aggregateMarketValue>
            <noOfUnitsOutstanding>26419511</noOfUnitsOutstanding>
            <approxSaleDate>06/30/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>08/13/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Exercised Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7500</amountOfSecuritiesAcquired>
            <paymentDate>08/13/2020</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANDRADE</name>
                <address>
                    <ns2:street1>PO BOX 13628, 68 TW ALEXANDER DRIVE</ns2:street1>
                    <ns2:city>Research Triangle Park</ns2:city>
                    <ns2:stateOrCountry>NC</ns2:stateOrCountry>
                    <ns2:zipCode>27709</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/29/2023</saleDate>
            <amountOfSecuritiesSold>7500</amountOfSecuritiesSold>
            <grossProceeds>67300.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANDRADE</name>
                <address>
                    <ns2:street1>PO BOX 13628, 68 TW ALEXANDER DRIVE</ns2:street1>
                    <ns2:city>Research Triangle Park</ns2:city>
                    <ns2:stateOrCountry>NC</ns2:stateOrCountry>
                    <ns2:zipCode>27709</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/28/2023</saleDate>
            <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
            <grossProceeds>89899.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/30/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/15/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Robert Andrade</signature>
        </noticeSignature>
    </formData>
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144
0001468308
XXXXXXXX
LIVE
0001211583
FENNEC PHARMACEUTICALS INC.
001-32295
PO BOX 13628, 68 TW ALEXANDER DRIVE
Research Triangle Park
NC
27709
(919) 636-4530
ROBERT ANDRADE
Officer
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
7500
66118.50
26419511
06/30/2023
NASD
COMMON
08/13/2020
Exercised Shares
ISSUER
N
7500
08/13/2020
Cash
N
ROBERT ANDRADE
PO BOX 13628, 68 TW ALEXANDER DRIVE
Research Triangle Park
NC
27709
Common
06/29/2023
7500
67300.50
ROBERT ANDRADE
PO BOX 13628, 68 TW ALEXANDER DRIVE
Research Triangle Park
NC
27709
Common
06/28/2023
10000
89899.00
06/30/2023
12/15/2022
/s/ Robert Andrade