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      <issuerAddress>
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        <com:stateOrCountry>WI</com:stateOrCountry>
        <com:zipCode>53719</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>608-284-5700</issuerContactPhone>
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      <relationshipsToIssuer>
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          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
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      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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      <isGiftTransaction>N</isGiftTransaction>
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      <paymentDate>02/19/2022</paymentDate>
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      <paymentDate>02/23/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
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    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/26/2022</acquiredDate>
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      <paymentDate>02/26/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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      <sellerDetails>
        <name>JAMES HERRIOTT</name>
        <address>
          <com:street1>5505 Endeavor Lane</com:street1>
          <com:city>Madison</com:city>
          <com:stateOrCountry>WI</com:stateOrCountry>
          <com:zipCode>53719</com:zipCode>
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      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
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      <grossProceeds>103805.00</grossProceeds>
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          <com:stateOrCountry>WI</com:stateOrCountry>
          <com:zipCode>53719</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/08/2023</saleDate>
      <amountOfSecuritiesSold>1300</amountOfSecuritiesSold>
      <grossProceeds>117000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>07/19/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>11/21/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Jennifer Ruchti, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for James Herriott</signature>
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144
0001957680
XXXXXXXX
LIVE
0001124140
EXACT SCIENCES CORP
001-35092
5505 ENDEAVOR LANE
MADISON
WI
53719
608-284-5700
Herriott James
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
1300
130000.00
180388167
07/19/2023
NASDAQ
Common
02/19/2022
Restricted Stock Vesting
Issuer
N
326
02/19/2022
Compensation
Common
02/23/2022
Restricted Stock Vesting
Issuer
N
849
02/23/2022
Compensation
Common
02/26/2022
Restricted Stock Vesting
Issuer
N
125
02/26/2022
Compensation
N
JAMES HERRIOTT
5505 Endeavor Lane
Madison
WI
53719
Common
05/10/2023
1300
103805.00
JAMES HERRIOTT
5505 Endeavor Lane
Madison
WI
53719
Common
06/08/2023
1300
117000.00
07/19/2023
11/21/2022
/s/ Jennifer Ruchti, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for James Herriott