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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerName>SI-BONE, INC.</issuerName>
            <secFileNumber>001-38701</secFileNumber>
            <issuerAddress>
                <ns2:street1>471 El Camino Real, Suite 101</ns2:street1>
                <ns2:city>Santa Clara</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>95050</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>4082070700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ANSHUL MAHESHWARI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2424</noOfUnitsSold>
            <aggregateMarketValue>47970.96</aggregateMarketValue>
            <noOfUnitsOutstanding>42614514</noOfUnitsOutstanding>
            <approxSaleDate>05/19/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/15/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2424</amountOfSecuritiesAcquired>
            <paymentDate>05/15/2025</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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            <sellerDetails>
                <name>10b5-1 Sales for ANSHUL MAHESHWARI</name>
                <address>
                    <ns2:street1>471 El Camino Real, Suite 101</ns2:street1>
                    <ns2:city>Santa Clara</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95050</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/16/2025</saleDate>
            <amountOfSecuritiesSold>4958</amountOfSecuritiesSold>
            <grossProceeds>99230.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ANSHUL MAHESHWARI</name>
                <address>
                    <ns2:street1>471 El Camino Real, Suite 101</ns2:street1>
                    <ns2:city>Santa Clara</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95050</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/12/2025</saleDate>
            <amountOfSecuritiesSold>4937</amountOfSecuritiesSold>
            <grossProceeds>93925.96</grossProceeds>
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        <securitiesSoldInPast3Months>
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                    <ns2:street1>471 El Camino Real, Suite 101</ns2:street1>
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                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95050</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/08/2025</saleDate>
            <amountOfSecuritiesSold>28350</amountOfSecuritiesSold>
            <grossProceeds>515093.99</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ANSHUL MAHESHWARI</name>
                <address>
                    <ns2:street1>471 El Camino Real, Suite 101</ns2:street1>
                    <ns2:city>Santa Clara</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95050</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/07/2025</saleDate>
            <amountOfSecuritiesSold>4937</amountOfSecuritiesSold>
            <grossProceeds>83939.33</grossProceeds>
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        <securitiesSoldInPast3Months>
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                <name>ANSHUL MAHESHWARI</name>
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                    <ns2:street1>471 El Camino Real, Suite 101</ns2:street1>
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                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>95050</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/02/2025</saleDate>
            <amountOfSecuritiesSold>3311</amountOfSecuritiesSold>
            <grossProceeds>46723.49</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/19/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/13/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Anshul Maheshwari</signature>
        </noticeSignature>
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144
0001853089
XXXXXXXX
LIVE
0001459839
SI-BONE, INC.
001-38701
471 El Camino Real, Suite 101
Santa Clara
CA
95050
4082070700
ANSHUL MAHESHWARI
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
2424
47970.96
42614514
05/19/2025
NASDAQ
Common
05/15/2025
Restricted Stock Units
Issuer
N
2424
05/15/2025
N/A
N
10b5-1 Sales for ANSHUL MAHESHWARI
471 El Camino Real, Suite 101
Santa Clara
CA
95050
Common
05/16/2025
4958
99230.40
10b5-1 Sales for ANSHUL MAHESHWARI
471 El Camino Real, Suite 101
Santa Clara
CA
95050
Common
05/12/2025
4937
93925.96
10b5-1 Sales for ANSHUL MAHESHWARI
471 El Camino Real, Suite 101
Santa Clara
CA
95050
Common
05/08/2025
28350
515093.99
10b5-1 Sales for ANSHUL MAHESHWARI
471 El Camino Real, Suite 101
Santa Clara
CA
95050
Common
05/07/2025
4937
83939.33
ANSHUL MAHESHWARI
471 El Camino Real, Suite 101
Santa Clara
CA
95050
Common
04/02/2025
3311
46723.49
05/19/2025
12/13/2024
/s/ Anshul Maheshwari