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                <filerCredentials>
                    <cik>0001237257</cik>
                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0000721371</issuerCik>
            <issuerName>CARDINAL HEALTH, INC.</issuerName>
            <secFileNumber>001-11373</secFileNumber>
            <issuerAddress>
                <ns2:street1>7000 Cardinal Place</ns2:street1>
                <ns2:city>Dublin</ns2:city>
                <ns2:stateOrCountry>OH</ns2:stateOrCountry>
                <ns2:zipCode>43017</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6147573033</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BRUCE DOWNEY &amp; DEBORAH DOWNEY </nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director.  Retired 11/15/2023</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>24890</noOfUnitsSold>
            <aggregateMarketValue>2661151.69</aggregateMarketValue>
            <noOfUnitsOutstanding>246468133</noOfUnitsOutstanding>
            <approxSaleDate>12/04/2023</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/21/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>24890</amountOfSecuritiesAcquired>
            <paymentDate>11/21/2023</paymentDate>
            <natureOfPayment>Compensation</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>12/04/2023</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Bruce Downey</signature>
        </noticeSignature>
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144
0001237257
XXXXXXXX
LIVE
0000721371
CARDINAL HEALTH, INC.
001-11373
7000 Cardinal Place
Dublin
OH
43017
6147573033
BRUCE DOWNEY & DEBORAH DOWNEY
Director.  Retired 11/15/2023
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
24890
2661151.69
246468133
12/04/2023
NYSE
Common
11/21/2023
Restricted stock vesting under a registered plan
Issuer
N
24890
11/21/2023
Compensation
Y
12/04/2023
/s/ Bruce Downey