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            <ns2:issuerContactPhone>1-866-788-9007</ns2:issuerContactPhone>
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            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
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            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
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        <ns2:securitiesSoldInPast3Months>
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            <ns2:grossProceeds>164654.14</ns2:grossProceeds>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>The Annette E. Bradbury Irrevocable Descendants Trust</ns2:name>
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            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>03/04/2024</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>7967</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>164736.85</ns2:grossProceeds>
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        <ns2:securitiesSoldInPast3Months>
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            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>03/04/2024</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>7393</ns2:amountOfSecuritiesSold>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>The Daniel M. Bradbury Irrevocable Descendants Trust</ns2:name>
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                <ns2:name>The Daniel M. Bradbury Irrevocable Descendants Trust</ns2:name>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>The Annette E. Bradbury Irrevocable Descendants Trust</ns2:name>
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            <ns2:grossProceeds>126960.74</ns2:grossProceeds>
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        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>BioBrit, LLC</ns2:name>
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                    <com:street2>SUITE 401</com:street2>
                    <com:city>FRIENDSWOOD</com:city>
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            <ns2:grossProceeds>117803.25</ns2:grossProceeds>
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        <ns2:remarks>Total number of shares to be sold includes 14,787 shares by BioBrit, LLC, 15,925 shares by The Daniel M. Bradbury Irrevocable Descendants Trust, 15,934  shares by The Annette E. Bradbury Irrevocable Descendants Trust. The sales set forth herein are made in connection with a selling plan dated 8/22/2023, that is intended to comply with Rule 105-1 (c).</ns2:remarks>
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            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of Daniel Bradbury</ns2:signature>
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144
0001236397
XXXXXXXX
LIVE
0001447362
Castle Biosciences, Inc.
001-38984
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
1-866-788-9007
Daniel Bradbury
Other: Affiliate
Common
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
46646
990761.04
27449983
04/04/2024
NASD
Common
12/08/2020
Gift
Daniel Bradbury
Y
01/30/2019
15934
01/30/2019
N/A
Common
12/08/2020
Gift
Daniel Bradbury
Y
01/30/2019
15925
01/30/2019
N/A
Common
06/06/2018
Private Transaction
Issuer
N
14787
06/06/2018
N/A
N
The Daniel M. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
02/07/2024
708
16427.79
The Annette E. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
02/07/2024
708
16427.79
BioBrit, LLC
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
02/07/2024
658
15267.64
The Daniel M. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
02/06/2024
3362
79455.83
The Annette E. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
02/06/2024
3364
79503.09
BioBrit, LLC
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
02/06/2024
3121
73760.15
The Daniel M. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
02/05/2024
3893
89155.15
The Annette E. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
02/05/2024
3895
89200.95
BioBrit, LLC
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
02/05/2024
3614
82765.66
The Daniel M. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
03/04/2024
7963
164654.14
The Annette E. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
03/04/2024
7967
164736.85
BioBrit, LLC
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
03/04/2024
7393
152868.02
The Daniel M. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
01/05/2024
1741
35441.54
The Annette E. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
01/05/2024
1742
35461.89
BioBrit, LLC
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
01/05/2024
1617
32917.27
The Daniel M. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
01/04/2024
6222
126899.56
The Annette E. Bradbury Irrevocable Descendants Trust
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
01/04/2024
6225
126960.74
BioBrit, LLC
505 S FRIENDSWOOD DR
SUITE 401
FRIENDSWOOD
TX
77546
Common
01/04/2024
5776
117803.25
Total number of shares to be sold includes 14,787 shares by BioBrit, LLC, 15,925 shares by The Daniel M. Bradbury Irrevocable Descendants Trust, 15,934  shares by The Annette E. Bradbury Irrevocable Descendants Trust. The sales set forth herein are made in connection with a selling plan dated 8/22/2023, that is intended to comply with Rule 105-1 (c).
04/04/2024
08/22/2023
Goldman Sachs & Co. LLC on behalf of Daniel Bradbury