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            <filer>
                <filerCredentials>
                    <cik>0001884375</cik>
                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001831840</issuerCik>
            <issuerName>SEMRUSH HOLDINGS, INC.</issuerName>
            <secFileNumber>001-40276</secFileNumber>
            <issuerAddress>
                <ns2:street1>800 BOYLSTON STREET, SUITE 2475</ns2:street1>
                <ns2:city>BOSTON</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02199</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>800-851-9959</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ANDREW WARDEN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>10656</noOfUnitsSold>
            <aggregateMarketValue>116036.38</aggregateMarketValue>
            <noOfUnitsOutstanding>148183469</noOfUnitsOutstanding>
            <approxSaleDate>05/13/2025</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>04/01/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>8361</amountOfSecuritiesAcquired>
            <paymentDate>04/01/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>10/01/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2295</amountOfSecuritiesAcquired>
            <paymentDate>10/01/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ANDREW WARDEN</name>
                <address>
                    <ns2:street1>800 BOYLSTON STREET, SUITE 2475</ns2:street1>
                    <ns2:city>BOSTON</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02199</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>05/12/2025</saleDate>
            <amountOfSecuritiesSold>7344</amountOfSecuritiesSold>
            <grossProceeds>79397.45</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Andrew Warden</name>
                <address>
                    <ns2:street1>800 BOYLSTON STREET, SUITE 2475</ns2:street1>
                    <ns2:city>BOSTON</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02199</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>04/02/2025</saleDate>
            <amountOfSecuritiesSold>3993</amountOfSecuritiesSold>
            <grossProceeds>37788.55</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Andrew Warden</name>
                <address>
                    <ns2:street1>800 BOYLSTON STREET, SUITE 2475</ns2:street1>
                    <ns2:city>BOSTON</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02199</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/03/2025</saleDate>
            <amountOfSecuritiesSold>17118</amountOfSecuritiesSold>
            <grossProceeds>191309.06</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>05/13/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Andrew Warden</signature>
        </noticeSignature>
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144
0001884375
XXXXXXXX
LIVE
0001831840
SEMRUSH HOLDINGS, INC.
001-40276
800 BOYLSTON STREET, SUITE 2475
BOSTON
MA
02199
800-851-9959
ANDREW WARDEN
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
10656
116036.38
148183469
05/13/2025
NYSE
Common
04/01/2023
Restricted Stock
Issuer
N
8361
04/01/2023
Not Applicable
Common
10/01/2022
Restricted Stock
Issuer
N
2295
10/01/2022
Not Applicable
N
ANDREW WARDEN
800 BOYLSTON STREET, SUITE 2475
BOSTON
MA
02199
Common
05/12/2025
7344
79397.45
Andrew Warden
800 BOYLSTON STREET, SUITE 2475
BOSTON
MA
02199
Common
04/02/2025
3993
37788.55
Andrew Warden
800 BOYLSTON STREET, SUITE 2475
BOSTON
MA
02199
Common
03/03/2025
17118
191309.06
05/13/2025
/s/ Andrew Warden