<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001718648</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001597264</issuerCik>
            <issuerName>BLUEPRINT MEDICINES CORPORATION</issuerName>
            <secFileNumber>001-37359</secFileNumber>
            <issuerAddress>
                <ns2:street1>45 Sidney Street</ns2:street1>
                <ns2:city>Cambridge</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02139</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(617) 374-7580</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CHRISTOPHER MURRAY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>621</noOfUnitsSold>
            <aggregateMarketValue>58158.82</aggregateMarketValue>
            <noOfUnitsOutstanding>61232297</noOfUnitsOutstanding>
            <approxSaleDate>03/04/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>03/01/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>621</amountOfSecuritiesAcquired>
            <paymentDate>03/01/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHRISTOPHER MURRAY</name>
                <address>
                    <ns2:street1>45 Sidney Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02139</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/28/2024</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>500000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>CHRISTOPHER MURRAY</name>
                <address>
                    <ns2:street1>45 Sidney Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02139</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/07/2023</saleDate>
            <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
            <grossProceeds>375000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>03/04/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>06/05/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Christopher Kenneth Murray</signature>
        </noticeSignature>
    </formData>
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144
0001718648
XXXXXXXX
LIVE
0001597264
BLUEPRINT MEDICINES CORPORATION
001-37359
45 Sidney Street
Cambridge
MA
02139
(617) 374-7580
CHRISTOPHER MURRAY
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
621
58158.82
61232297
03/04/2024
NASDAQ
COMMON
03/01/2022
Restricted Stock
ISSUER
N
621
03/01/2022
Not Applicable
N
CHRISTOPHER MURRAY
45 Sidney Street
Cambridge
MA
02139
Common
02/28/2024
5000
500000.00
CHRISTOPHER MURRAY
45 Sidney Street
Cambridge
MA
02139
Common
12/07/2023
5000
375000.00
03/04/2024
06/05/2023
/s/ Christopher Kenneth Murray