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    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001579829</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001771917</issuerCik>
      <issuerName>Karuna Therapeutics, Inc.</issuerName>
      <secFileNumber>001-38958</secFileNumber>
      <issuerAddress>
        <com:street1>99 HIGH STREET</com:street1>
        <com:street2>26TH FLOOR</com:street2>
        <com:city>BOSTON</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02110</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>857-449-2244</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Ignelzi Troy A.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Former Affiliate</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>6000</noOfUnitsSold>
      <aggregateMarketValue>1121923.00</aggregateMarketValue>
      <noOfUnitsOutstanding>37727117</noOfUnitsOutstanding>
      <approxSaleDate>11/28/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>11/28/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Stock Option Exercise - see remarks</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Karuna Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6000</amountOfSecuritiesAcquired>
      <paymentDate>11/28/2023</paymentDate>
      <natureOfPayment>Broker Payment for Cashless Exercise</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>TROY IGNELZI</name>
        <address>
          <com:street1>99 HIGH STREET</com:street1>
          <com:street2>26TH FLOOR</com:street2>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Karuna Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>11/21/2023</saleDate>
      <amountOfSecuritiesSold>1500</amountOfSecuritiesSold>
      <grossProceeds>278687.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>TROY IGNELZI</name>
        <address>
          <com:street1>99 HIGH STREET, 26TH FLOOR</com:street1>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Karuna Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>11/22/2023</saleDate>
      <amountOfSecuritiesSold>1000</amountOfSecuritiesSold>
      <grossProceeds>187039.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>TROY IGNELZI</name>
        <address>
          <com:street1>99 HIGH STREET, 26TH FLOOR</com:street1>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Karuna Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>11/24/2023</saleDate>
      <amountOfSecuritiesSold>1000</amountOfSecuritiesSold>
      <grossProceeds>189018.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The options covered by this filing, may be sold over various dates.</remarks>
    <noticeSignature>
      <noticeDate>11/28/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>12/12/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>TROY IGNELZI</signature>
    </noticeSignature>
  </formData>
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144
0001579829
XXXXXXXX
LIVE
0001771917
Karuna Therapeutics, Inc.
001-38958
99 HIGH STREET
26TH FLOOR
BOSTON
MA
02110
857-449-2244
Ignelzi Troy A.
Former Affiliate
Common
Charles Schwab & Co., Inc.
3000 Schwab Way
Westlake
TX
76262
6000
1121923.00
37727117
11/28/2023
NASDAQ
Common
11/28/2023
Employee Stock Option Exercise - see remarks
Karuna Therapeutics, Inc.
N
6000
11/28/2023
Broker Payment for Cashless Exercise
N
TROY IGNELZI
99 HIGH STREET
26TH FLOOR
BOSTON
MA
02110
Karuna Therapeutics, Inc.
11/21/2023
1500
278687.00
TROY IGNELZI
99 HIGH STREET, 26TH FLOOR
BOSTON
MA
02110
Karuna Therapeutics, Inc.
11/22/2023
1000
187039.00
TROY IGNELZI
99 HIGH STREET, 26TH FLOOR
BOSTON
MA
02110
Karuna Therapeutics, Inc.
11/24/2023
1000
189018.00
The options covered by this filing, may be sold over various dates.
11/28/2023
12/12/2022
TROY IGNELZI