<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001914769</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001404644</issuerCik>
            <issuerName>NEUROGENE INC.</issuerName>
            <secFileNumber>001-36327</secFileNumber>
            <issuerAddress>
                <ns2:street1>535 W 24th Street</ns2:street1>
                <ns2:street2>5th Floor</ns2:street2>
                <ns2:city>New York</ns2:city>
                <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                <ns2:zipCode>10011</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(877) 237-5020</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SEAN SMITH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>371</noOfUnitsSold>
            <aggregateMarketValue>13567.28</aggregateMarketValue>
            <noOfUnitsOutstanding>9397901</noOfUnitsOutstanding>
            <approxSaleDate>03/04/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/15/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>28</amountOfSecuritiesAcquired>
            <paymentDate>11/15/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/14/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>78</amountOfSecuritiesAcquired>
            <paymentDate>05/14/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/15/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>100</amountOfSecuritiesAcquired>
            <paymentDate>05/15/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/21/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1</amountOfSecuritiesAcquired>
            <paymentDate>11/21/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/13/2020</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>66</amountOfSecuritiesAcquired>
            <paymentDate>11/13/2020</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/15/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>100</amountOfSecuritiesAcquired>
            <paymentDate>11/15/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SEAN SMITH</name>
                <address>
                    <ns2:street1>535 W 24th Street</ns2:street1>
                    <ns2:street2>5th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10011</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/15/2024</saleDate>
            <amountOfSecuritiesSold>1141</amountOfSecuritiesSold>
            <grossProceeds>34800.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SEAN SMITH</name>
                <address>
                    <ns2:street1>535 W 24th Street</ns2:street1>
                    <ns2:street2>5th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10011</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/12/2024</saleDate>
            <amountOfSecuritiesSold>153</amountOfSecuritiesSold>
            <grossProceeds>4666.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SEAN SMITH</name>
                <address>
                    <ns2:street1>535 W 24th Street</ns2:street1>
                    <ns2:street2>5th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10011</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/26/2023</saleDate>
            <amountOfSecuritiesSold>141</amountOfSecuritiesSold>
            <grossProceeds>2224.98</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SEAN SMITH</name>
                <address>
                    <ns2:street1>535 W 24th Street</ns2:street1>
                    <ns2:street2>5th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10011</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/21/2023</saleDate>
            <amountOfSecuritiesSold>1</amountOfSecuritiesSold>
            <grossProceeds>10.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>03/04/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Sean Michael Smith</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 9151}]
144
0001914769
XXXXXXXX
LIVE
0001404644
NEUROGENE INC.
001-36327
535 W 24th Street
5th Floor
New York
NY
10011
(877) 237-5020
SEAN SMITH
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
371
13567.28
9397901
03/04/2024
NASDAQ
Common
11/15/2021
Employee Stock Purchase Plan
Issuer
N
28
11/15/2021
Cash
Common
05/14/2021
Employee Stock Purchase Plan
Issuer
N
78
05/14/2021
Cash
Common
05/15/2023
Employee Stock Purchase Plan
Issuer
N
100
05/15/2023
Cash
Common
11/21/2023
Employee Stock Purchase Plan
Issuer
N
1
11/21/2023
Cash
Common
11/13/2020
Employee Stock Purchase Plan
Issuer
N
66
11/13/2020
Cash
Common
11/15/2023
Employee Stock Purchase Plan
Issuer
N
100
11/15/2023
Cash
N
SEAN SMITH
535 W 24th Street
5th Floor
New York
NY
10011
Common
01/15/2024
1141
34800.00
SEAN SMITH
535 W 24th Street
5th Floor
New York
NY
10011
Common
01/12/2024
153
4666.00
SEAN SMITH
535 W 24th Street
5th Floor
New York
NY
10011
Common
12/26/2023
141
2224.98
SEAN SMITH
535 W 24th Street
5th Floor
New York
NY
10011
Common
12/21/2023
1
10.00
03/04/2024
/s/ Sean Michael Smith