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          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



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    <issuerInfo>
      <issuerCik>0001604821</issuerCik>
      <issuerName>Natera, Inc.</issuerName>
      <secFileNumber>001-37478</secFileNumber>
      <issuerAddress>
        <com:street1>13011 MCCALLEN PASS</com:street1>
        <com:street2>BUILDING A SUITE 100</com:street2>
        <com:city>AUSTIN</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>78753</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>650-249-9090</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sheena Jonathan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>15546</noOfUnitsSold>
      <aggregateMarketValue>739367.00</aggregateMarketValue>
      <noOfUnitsOutstanding>114301688</noOfUnitsOutstanding>
      <approxSaleDate>07/21/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/19/2021</acquiredDate>
      <natureOfAcquisitionTransaction>VARIOUS</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>15546</amountOfSecuritiesAcquired>
      <paymentDate>01/19/2021</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Jonathan Sheena</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/07/2023</saleDate>
      <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
      <grossProceeds>245627.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Jonathan Sheena</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/28/2023</saleDate>
      <amountOfSecuritiesSold>5313</amountOfSecuritiesSold>
      <grossProceeds>270049.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Jonathan Sheena</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass,</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>04/24/2023</saleDate>
      <amountOfSecuritiesSold>43</amountOfSecuritiesSold>
      <grossProceeds>2364.14</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Jonathan Sheena</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass,</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>05/10/2023</saleDate>
      <amountOfSecuritiesSold>5000</amountOfSecuritiesSold>
      <grossProceeds>270500.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>SOUTH DAKOTA TRUST COMPANY LLC CARALUNA 2 TRUST Grantor JONATHAN SHEENA</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass,</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>06/07/2023</saleDate>
      <amountOfSecuritiesSold>500</amountOfSecuritiesSold>
      <grossProceeds>24547.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>SOUTH DAKOTA TRUST COMPANY LLC CARALUNA 1 TR</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass,</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>06/07/2023</saleDate>
      <amountOfSecuritiesSold>500</amountOfSecuritiesSold>
      <grossProceeds>24547.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Shares Acquired via various Methods of Acquisition &amp; Dates.</remarks>
    <noticeSignature>
      <noticeDate>07/21/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>12/13/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>Jonathan Sheena</signature>
    </noticeSignature>
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144
0001646649
XXXXXXXX
LIVE
0001604821
Natera, Inc.
001-37478
13011 MCCALLEN PASS
BUILDING A SUITE 100
AUSTIN
TX
78753
650-249-9090
Sheena Jonathan
Director
Common
Charles Schwab & Co., Inc.
3000 Schwab Way
Westlake
TX
76262
15546
739367.00
114301688
07/21/2023
NASDAQ
Common
01/19/2021
VARIOUS
ISSUER
N
15546
01/19/2021
NA
N
Jonathan Sheena
C/O 13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
06/07/2023
5000
245627.00
Jonathan Sheena
C/O 13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
06/28/2023
5313
270049.00
Jonathan Sheena
C/O 13011 McCallen Pass,
Building A Suite 100
Austin
TX
78753
COMMON
04/24/2023
43
2364.14
Jonathan Sheena
C/O 13011 McCallen Pass,
Building A Suite 100
Austin
TX
78753
COMMON
05/10/2023
5000
270500.00
SOUTH DAKOTA TRUST COMPANY LLC CARALUNA 2 TRUST Grantor JONATHAN SHEENA
C/O 13011 McCallen Pass,
Building A Suite 100
Austin
TX
78753
COMMON
06/07/2023
500
24547.00
SOUTH DAKOTA TRUST COMPANY LLC CARALUNA 1 TR
C/O 13011 McCallen Pass,
Building A Suite 100
Austin
TX
78753
COMMON
06/07/2023
500
24547.00
Shares Acquired via various Methods of Acquisition & Dates.
07/21/2023
12/13/2022
Jonathan Sheena