<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001821102</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001802665</issuerCik>
            <issuerName>HARMONY BIOSCIENCES HLDGS INC</issuerName>
            <secFileNumber>001-39450</secFileNumber>
            <issuerAddress>
                <ns2:street1>630 W Germantown Pike, Suite 215</ns2:street1>
                <ns2:city>Plymouth Meeting</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19462</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>4845399800</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JEFFREY G DIERKS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>28971</noOfUnitsSold>
            <aggregateMarketValue>1152756.09</aggregateMarketValue>
            <noOfUnitsOutstanding>56834745</noOfUnitsOutstanding>
            <approxSaleDate>09/27/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/27/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>28971</amountOfSecuritiesAcquired>
            <paymentDate>09/27/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>09/27/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/23/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jeffrey G Dierks</signature>
        </noticeSignature>
    </formData>
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144
0001821102
XXXXXXXX
LIVE
0001802665
HARMONY BIOSCIENCES HLDGS INC
001-39450
630 W Germantown Pike, Suite 215
Plymouth Meeting
PA
19462
4845399800
JEFFREY G DIERKS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
28971
1152756.09
56834745
09/27/2024
NASDAQ
Common
09/27/2024
Exercise of Stock Options
Issuer
N
28971
09/27/2024
Cash
Y
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
09/27/2024
02/23/2024
/s/ Jeffrey G Dierks