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            <liveTestFlag>LIVE</liveTestFlag>



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            <secFileNumber>001-34632</secFileNumber>
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                <ns2:city>Brentwood</ns2:city>
                <ns2:stateOrCountry>TN</ns2:stateOrCountry>
                <ns2:zipCode>37027</ns2:zipCode>
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            <issuerContactPhone>949-470-2300</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>RAMKUMAR MANDALAM</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>13321</noOfUnitsSold>
            <aggregateMarketValue>87385.76</aggregateMarketValue>
            <noOfUnitsOutstanding>50137218</noOfUnitsOutstanding>
            <approxSaleDate>06/24/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/24/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>13321</amountOfSecuritiesAcquired>
            <paymentDate>06/24/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <address>
                    <ns2:street1>112 Westwood Place, Suite 350</ns2:street1>
                    <ns2:city>Brentwood</ns2:city>
                    <ns2:stateOrCountry>TN</ns2:stateOrCountry>
                    <ns2:zipCode>37027</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2025</saleDate>
            <amountOfSecuritiesSold>624</amountOfSecuritiesSold>
            <grossProceeds>4246.13</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>RAMKUMAR MANDALAM</name>
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                    <ns2:stateOrCountry>TN</ns2:stateOrCountry>
                    <ns2:zipCode>37027</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/12/2025</saleDate>
            <amountOfSecuritiesSold>1895</amountOfSecuritiesSold>
            <grossProceeds>13286.41</grossProceeds>
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            <sellerDetails>
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                    <ns2:stateOrCountry>TN</ns2:stateOrCountry>
                    <ns2:zipCode>37027</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/11/2025</saleDate>
            <amountOfSecuritiesSold>8193</amountOfSecuritiesSold>
            <grossProceeds>57815.54</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
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                <address>
                    <ns2:street1>112 Westwood Place, Suite 350</ns2:street1>
                    <ns2:city>Brentwood</ns2:city>
                    <ns2:stateOrCountry>TN</ns2:stateOrCountry>
                    <ns2:zipCode>37027</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/09/2025</saleDate>
            <amountOfSecuritiesSold>5622</amountOfSecuritiesSold>
            <grossProceeds>39672.77</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/24/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Ramkumar Mandalam</signature>
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144
0001611439
XXXXXXXX
LIVE
0001124524
CRYOPORT INC
001-34632
112 Westwood Place, Suite 350
Brentwood
TN
37027
949-470-2300
RAMKUMAR MANDALAM
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
13321
87385.76
50137218
06/24/2025
NASDAQ
Common
06/24/2025
Exercise of Stock Options
Issuer
N
13321
06/24/2025
Cash
N
RAMKUMAR MANDALAM
112 Westwood Place, Suite 350
Brentwood
TN
37027
Common
06/13/2025
624
4246.13
RAMKUMAR MANDALAM
112 Westwood Place, Suite 350
Brentwood
TN
37027
Common
06/12/2025
1895
13286.41
RAMKUMAR MANDALAM
112 Westwood Place, Suite 350
Brentwood
TN
37027
Common
06/11/2025
8193
57815.54
RAMKUMAR MANDALAM
112 Westwood Place, Suite 350
Brentwood
TN
37027
Common
06/09/2025
5622
39672.77
06/24/2025
/s/ Ramkumar Mandalam