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            <filer>
                <filerCredentials>
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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001785173</issuerCik>
            <issuerName>89BIO, INC.</issuerName>
            <secFileNumber>001-39122</secFileNumber>
            <issuerAddress>
                <ns2:street1>655 Montgomery</ns2:street1>
                <ns2:street2>Suite 1500</ns2:street2>
                <ns2:city>San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94111</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(415) 432-9270</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>QUOC LE-NGUYEN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>15329</noOfUnitsSold>
            <aggregateMarketValue>91170.76</aggregateMarketValue>
            <noOfUnitsOutstanding>145984182</noOfUnitsOutstanding>
            <approxSaleDate>04/15/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/05/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>15329</amountOfSecuritiesAcquired>
            <paymentDate>01/05/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/15/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>07/01/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Quoc Le-Nguyen</signature>
        </noticeSignature>
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144
0001792062
XXXXXXXX
LIVE
0001785173
89BIO, INC.
001-39122
655 Montgomery
Suite 1500
San Francisco
CA
94111
(415) 432-9270
QUOC LE-NGUYEN
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
15329
91170.76
145984182
04/15/2025
NASDAQ
Common
01/05/2024
Performance Shares
ISSUER
N
15329
01/05/2024
Not Applicable
Y
04/15/2025
07/01/2024
/s/ Quoc Le-Nguyen