<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0002007050</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001840706</issuerCik>
            <issuerName>SOPHIA GENETICS SA</issuerName>
            <secFileNumber>001-40627</secFileNumber>
            <issuerAddress>
                <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                <ns2:city>Rolle</ns2:city>
                <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                <ns2:zipCode>00000</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>41216941060</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JURGI CAMBLONG</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>40343</noOfUnitsSold>
            <aggregateMarketValue>133535.33</aggregateMarketValue>
            <noOfUnitsOutstanding>65230559</noOfUnitsOutstanding>
            <approxSaleDate>12/24/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/18/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>40343</amountOfSecuritiesAcquired>
            <paymentDate>12/18/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/19/2024</saleDate>
            <amountOfSecuritiesSold>5839</amountOfSecuritiesSold>
            <grossProceeds>19268.70</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/22/2024</saleDate>
            <amountOfSecuritiesSold>5838</amountOfSecuritiesSold>
            <grossProceeds>19265.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JURGI CAMBLONG</name>
                <address>
                    <ns2:street1>La Piece 12 ch-1180</ns2:street1>
                    <ns2:city>Rolle</ns2:city>
                    <ns2:stateOrCountry>V8</ns2:stateOrCountry>
                    <ns2:zipCode>00000</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/04/2024</saleDate>
            <amountOfSecuritiesSold>21456</amountOfSecuritiesSold>
            <grossProceeds>69517.44</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 12/18/2024 through 03/18/2025.
Sales that were executed on December 24, 2024 are being reported on this Form 144 filed on December 26, 2024 given the EDGAR system was not accepting filings on December 24, 2024, which is being treated as a federal holiday for filing purposes.</remarks>
        <noticeSignature>
            <noticeDate>12/24/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/09/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Jurgi Camblong</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 5837}]
144
0002007050
XXXXXXXX
LIVE
0001840706
SOPHIA GENETICS SA
001-40627
La Piece 12 ch-1180
Rolle
V8
00000
41216941060
JURGI CAMBLONG
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
40343
133535.33
65230559
12/24/2024
NASDAQ
Common
12/18/2024
Restricted Stock Units
Issuer
N
40343
12/18/2024
N/A
N
JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
11/19/2024
5839
19268.70
JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
10/22/2024
5838
19265.40
JURGI CAMBLONG
La Piece 12 ch-1180
Rolle
V8
00000
Common
10/04/2024
21456
69517.44
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 12/18/2024 through 03/18/2025.
Sales that were executed on December 24, 2024 are being reported on this Form 144 filed on December 26, 2024 given the EDGAR system was not accepting filings on December 24, 2024, which is being treated as a federal holiday for filing purposes.
12/24/2024
09/09/2024
/s/ Jurgi Camblong