<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001785299</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001703647</issuerCik>
      <issuerName>Frequency Therapeutics, Inc.</issuerName>
      <secFileNumber>001-39062</secFileNumber>
      <issuerAddress>
        <com:street1>75 HAYDEN AVENUE</com:street1>
        <com:street2>SUITE 300</com:street2>
        <com:city>LEXINGTON</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02421</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>781-315-4600</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Loose Christopher R.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1378</noOfUnitsSold>
      <aggregateMarketValue>783.81</aggregateMarketValue>
      <noOfUnitsOutstanding>35751956</noOfUnitsOutstanding>
      <approxSaleDate>08/03/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>08/02/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1378</amountOfSecuritiesAcquired>
      <paymentDate>08/02/2023</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/06/2023</saleDate>
      <amountOfSecuritiesSold>1384</amountOfSecuritiesSold>
      <grossProceeds>469.73</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/07/2023</saleDate>
      <amountOfSecuritiesSold>1306</amountOfSecuritiesSold>
      <grossProceeds>467.94</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/10/2023</saleDate>
      <amountOfSecuritiesSold>1304</amountOfSecuritiesSold>
      <grossProceeds>487.57</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/11/2023</saleDate>
      <amountOfSecuritiesSold>1363</amountOfSecuritiesSold>
      <grossProceeds>507.31</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/12/2023</saleDate>
      <amountOfSecuritiesSold>1335</amountOfSecuritiesSold>
      <grossProceeds>521.18</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/13/2023</saleDate>
      <amountOfSecuritiesSold>1329</amountOfSecuritiesSold>
      <grossProceeds>521.23</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/14/2023</saleDate>
      <amountOfSecuritiesSold>906</amountOfSecuritiesSold>
      <grossProceeds>534.63</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/17/2023</saleDate>
      <amountOfSecuritiesSold>1415</amountOfSecuritiesSold>
      <grossProceeds>947.77</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/18/2023</saleDate>
      <amountOfSecuritiesSold>1484</amountOfSecuritiesSold>
      <grossProceeds>827.92</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/19/2023</saleDate>
      <amountOfSecuritiesSold>1335</amountOfSecuritiesSold>
      <grossProceeds>861.74</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/20/2023</saleDate>
      <amountOfSecuritiesSold>1361</amountOfSecuritiesSold>
      <grossProceeds>871.86</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MD</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/21/2023</saleDate>
      <amountOfSecuritiesSold>1333</amountOfSecuritiesSold>
      <grossProceeds>814.86</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/24/2023</saleDate>
      <amountOfSecuritiesSold>1438</amountOfSecuritiesSold>
      <grossProceeds>781.55</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/25/2023</saleDate>
      <amountOfSecuritiesSold>1390</amountOfSecuritiesSold>
      <grossProceeds>694.58</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/26/2023</saleDate>
      <amountOfSecuritiesSold>1329</amountOfSecuritiesSold>
      <grossProceeds>679.38</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/27/2023</saleDate>
      <amountOfSecuritiesSold>1373</amountOfSecuritiesSold>
      <grossProceeds>722.47</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue, Suite 300</com:street1>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/28/2023</saleDate>
      <amountOfSecuritiesSold>1344</amountOfSecuritiesSold>
      <grossProceeds>623.35</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/31/2023</saleDate>
      <amountOfSecuritiesSold>1329</amountOfSecuritiesSold>
      <grossProceeds>668.22</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>08/01/2023</saleDate>
      <amountOfSecuritiesSold>1397</amountOfSecuritiesSold>
      <grossProceeds>682.43</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christopher Loose</name>
        <address>
          <com:street1>75 Hayden Avenue, Suite 300</com:street1>
          <com:city>Lexington</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02421</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>08/02/2023</saleDate>
      <amountOfSecuritiesSold>1293</amountOfSecuritiesSold>
      <grossProceeds>671.45</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>08/03/2023</noticeDate>
      <signature>/s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Christopher Loose</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 15403}]
144
0001785299
XXXXXXXX
LIVE
0001703647
Frequency Therapeutics, Inc.
001-39062
75 HAYDEN AVENUE
SUITE 300
LEXINGTON
MA
02421
781-315-4600
Loose Christopher R.
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
1378
783.81
35751956
08/03/2023
NASDAQ
Common
08/02/2023
Restricted Stock Vesting
Issuer
N
1378
08/02/2023
Compensation
N
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/06/2023
1384
469.73
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/07/2023
1306
467.94
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/10/2023
1304
487.57
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/11/2023
1363
507.31
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/12/2023
1335
521.18
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/13/2023
1329
521.23
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/14/2023
906
534.63
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/17/2023
1415
947.77
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/18/2023
1484
827.92
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/19/2023
1335
861.74
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/20/2023
1361
871.86
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MD
02421
Common
07/21/2023
1333
814.86
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/24/2023
1438
781.55
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/25/2023
1390
694.58
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/26/2023
1329
679.38
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/27/2023
1373
722.47
Christopher Loose
75 Hayden Avenue, Suite 300
Lexington
MA
02421
Common
07/28/2023
1344
623.35
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
07/31/2023
1329
668.22
Christopher Loose
75 Hayden Avenue
Suite 300
Lexington
MA
02421
Common
08/01/2023
1397
682.43
Christopher Loose
75 Hayden Avenue, Suite 300
Lexington
MA
02421
Common
08/02/2023
1293
671.45
08/03/2023
/s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Christopher Loose