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    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0002006961</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001571949</issuerCik>
            <issuerName>INTERCONTINENTAL EXCHANGE, INC.</issuerName>
            <secFileNumber>001-36198</secFileNumber>
            <issuerAddress>
                <ns2:street1>5660 NEW NORTHSIDE DRIVE</ns2:street1>
                <ns2:city>ATLANTA</ns2:city>
                <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                <ns2:zipCode>30328</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>770-857-4700</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ELIZABETH K KING</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>3783</noOfUnitsSold>
            <aggregateMarketValue>499469.49</aggregateMarketValue>
            <noOfUnitsOutstanding>572616425</noOfUnitsOutstanding>
            <approxSaleDate>02/08/2024</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>02/18/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3783</amountOfSecuritiesAcquired>
            <paymentDate>02/18/2022</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ELIZABETH K KING</name>
                <address>
                    <ns2:street1>5660 NEW NORTHSIDE DRIVE</ns2:street1>
                    <ns2:city>ATLANTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30328</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/13/2023</saleDate>
            <amountOfSecuritiesSold>10939</amountOfSecuritiesSold>
            <grossProceeds>1312754.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>02/08/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/23/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Elizabeth Kathryn King</signature>
        </noticeSignature>
    </formData>
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144
0002006961
XXXXXXXX
LIVE
0001571949
INTERCONTINENTAL EXCHANGE, INC.
001-36198
5660 NEW NORTHSIDE DRIVE
ATLANTA
GA
30328
770-857-4700
ELIZABETH K KING
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
3783
499469.49
572616425
02/08/2024
NYSE
COMMON
02/18/2022
Performance Shares
ISSUER
N
3783
02/18/2022
Not Applicable
N
ELIZABETH K KING
5660 NEW NORTHSIDE DRIVE
ATLANTA
GA
30328
Common
12/13/2023
10939
1312754.00
02/08/2024
11/23/2022
/s/ Elizabeth Kathryn King