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    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001766042</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001484565</issuerCik>
            <issuerName>SOLENO THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-36593</secFileNumber>
            <issuerAddress>
                <ns2:street1>100 Marine Parkway</ns2:street1>
                <ns2:street2>Suite 400</ns2:street2>
                <ns2:city>Redwood City</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94065</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 213-8444</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PATRICIA HIRANO</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>3830</noOfUnitsSold>
            <aggregateMarketValue>316970.80</aggregateMarketValue>
            <noOfUnitsOutstanding>50393931</noOfUnitsOutstanding>
            <approxSaleDate>07/01/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/30/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3830</amountOfSecuritiesAcquired>
            <paymentDate>06/30/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>PATRICIA HIRANO</name>
                <address>
                    <ns2:street1>100 Marine Parkway</ns2:street1>
                    <ns2:street2>Suite 400</ns2:street2>
                    <ns2:city>Redwood City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94065</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/24/2025</saleDate>
            <amountOfSecuritiesSold>266</amountOfSecuritiesSold>
            <grossProceeds>22410.50</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>07/01/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/13/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Patricia Colleen Hirano</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001766042
XXXXXXXX
LIVE
0001484565
SOLENO THERAPEUTICS, INC.
001-36593
100 Marine Parkway
Suite 400
Redwood City
CA
94065
(650) 213-8444
PATRICIA HIRANO
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
3830
316970.80
50393931
07/01/2025
NASDAQ
Common
06/30/2024
Restricted Stock
Issuer
N
3830
06/30/2024
Not Applicable
N
PATRICIA HIRANO
100 Marine Parkway
Suite 400
Redwood City
CA
94065
Common
06/24/2025
266
22410.50
07/01/2025
09/13/2024
/s/ Patricia Colleen Hirano