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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001959229</cik>
                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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        <issuerInfo>
            <issuerCik>0001812364</issuerCik>
            <issuerName>RELAY THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-39385</secFileNumber>
            <issuerAddress>
                <ns2:street1>399 Binney Street</ns2:street1>
                <ns2:city>Cambridge</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02142</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(617)  370-8837</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PETER J RAHMER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>32177</noOfUnitsSold>
            <aggregateMarketValue>138489.81</aggregateMarketValue>
            <noOfUnitsOutstanding>167382958</noOfUnitsOutstanding>
            <approxSaleDate>01/03/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/31/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>32177</amountOfSecuritiesAcquired>
            <paymentDate>12/31/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>PETER J RAHMER</name>
                <address>
                    <ns2:street1>399 Binney Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02142</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/02/2025</saleDate>
            <amountOfSecuritiesSold>32156</amountOfSecuritiesSold>
            <grossProceeds>133447.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>PETER J RAHMER</name>
                <address>
                    <ns2:street1>399 Binney Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02142</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/27/2024</saleDate>
            <amountOfSecuritiesSold>400</amountOfSecuritiesSold>
            <grossProceeds>1752.03</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>PETER J RAHMER</name>
                <address>
                    <ns2:street1>399 Binney Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02142</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/28/2024</saleDate>
            <amountOfSecuritiesSold>1621</amountOfSecuritiesSold>
            <grossProceeds>9823.26</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>01/03/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/22/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Peter Joseph Rahmer</signature>
        </noticeSignature>
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144
0001959229
XXXXXXXX
LIVE
0001812364
RELAY THERAPEUTICS, INC.
001-39385
399 Binney Street
Cambridge
MA
02142
(617)  370-8837
PETER J RAHMER
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
32177
138489.81
167382958
01/03/2025
NASDAQ
Common
12/31/2024
Restricted Stock
ISSUER
N
32177
12/31/2024
Not Applicable
N
PETER J RAHMER
399 Binney Street
Cambridge
MA
02142
Common
01/02/2025
32156
133447.40
PETER J RAHMER
399 Binney Street
Cambridge
MA
02142
Common
12/27/2024
400
1752.03
PETER J RAHMER
399 Binney Street
Cambridge
MA
02142
Common
10/28/2024
1621
9823.26
01/03/2025
02/22/2024
/s/ Peter Joseph Rahmer