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        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001853529</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001710072</issuerCik>
            <issuerName>EDGEWISE THERAPEUTICS INC</issuerName>
            <secFileNumber>001-40236</secFileNumber>
            <issuerAddress>
                <ns2:street1>1715 38th Street</ns2:street1>
                <ns2:city>Boulder</ns2:city>
                <ns2:stateOrCountry>CO</ns2:stateOrCountry>
                <ns2:zipCode>80301</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>7202627002</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ALAN J RUSSELL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>100000</noOfUnitsSold>
            <aggregateMarketValue>2950000.00</aggregateMarketValue>
            <noOfUnitsOutstanding>94688517</noOfUnitsOutstanding>
            <approxSaleDate>02/05/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/05/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>100000</amountOfSecuritiesAcquired>
            <paymentDate>02/05/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for ALAN J RUSSELL</name>
                <address>
                    <ns2:street1>1715 38th Street</ns2:street1>
                    <ns2:city>Boulder</ns2:city>
                    <ns2:stateOrCountry>CO</ns2:stateOrCountry>
                    <ns2:zipCode>80301</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/30/2024</saleDate>
            <amountOfSecuritiesSold>100000</amountOfSecuritiesSold>
            <grossProceeds>2737470.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>02/05/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/30/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Alan J Russell</signature>
        </noticeSignature>
    </formData>
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144
0001853529
XXXXXXXX
LIVE
0001710072
EDGEWISE THERAPEUTICS INC
001-40236
1715 38th Street
Boulder
CO
80301
7202627002
ALAN J RUSSELL
Director
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
100000
2950000.00
94688517
02/05/2025
NASDAQ
Common
02/05/2025
Exercise of Stock Options
Issuer
N
100000
02/05/2025
Cash
N
10b5-1 Sales for ALAN J RUSSELL
1715 38th Street
Boulder
CO
80301
Common
12/30/2024
100000
2737470.00
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
02/05/2025
09/30/2024
/s/ Alan J Russell