<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001870674</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001534969</issuerCik>
            <issuerName>SERA PROGNOSTICS INC</issuerName>
            <secFileNumber>001-40606</secFileNumber>
            <issuerAddress>
                <ns2:street1>2749 East Parleys Way, Suite 200</ns2:street1>
                <ns2:city>Salt Lake City</ns2:city>
                <ns2:stateOrCountry>UT</ns2:stateOrCountry>
                <ns2:zipCode>84109</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>801-990-0520</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JOHN BONIFACE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>120737</noOfUnitsSold>
            <aggregateMarketValue>1207370.00</aggregateMarketValue>
            <noOfUnitsOutstanding>31457902</noOfUnitsOutstanding>
            <approxSaleDate>03/25/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/25/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>73383</amountOfSecuritiesAcquired>
            <paymentDate>03/25/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/06/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>47354</amountOfSecuritiesAcquired>
            <paymentDate>12/06/2021</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JOHN J BONIFACE</name>
                <address>
                    <ns2:street1>2749 East Parleys Way, Suite 200</ns2:street1>
                    <ns2:city>Salt Lake City</ns2:city>
                    <ns2:stateOrCountry>UT</ns2:stateOrCountry>
                    <ns2:zipCode>84109</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/06/2024</saleDate>
            <amountOfSecuritiesSold>1664</amountOfSecuritiesSold>
            <grossProceeds>15009.28</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JOHN J BONIFACE</name>
                <address>
                    <ns2:street1>2749 East Parleys Way, Suite 200</ns2:street1>
                    <ns2:city>Salt Lake City</ns2:city>
                    <ns2:stateOrCountry>UT</ns2:stateOrCountry>
                    <ns2:zipCode>84109</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/06/2024</saleDate>
            <amountOfSecuritiesSold>5665</amountOfSecuritiesSold>
            <grossProceeds>45489.95</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 12/06/2021 through 09/08/2022.
</remarks>
        <noticeSignature>
            <noticeDate>03/25/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/15/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ John Boniface</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001870674
XXXXXXXX
LIVE
0001534969
SERA PROGNOSTICS INC
001-40606
2749 East Parleys Way, Suite 200
Salt Lake City
UT
84109
801-990-0520
JOHN BONIFACE
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
120737
1207370.00
31457902
03/25/2024
NASDAQ
Common
03/25/2024
Exercise of Stock Options
Issuer
N
73383
03/25/2024
Cash
Common
12/06/2021
Restricted Stock Units
Issuer
N
47354
12/06/2021
N/A
N
JOHN J BONIFACE
2749 East Parleys Way, Suite 200
Salt Lake City
UT
84109
Common
03/06/2024
1664
15009.28
JOHN J BONIFACE
2749 East Parleys Way, Suite 200
Salt Lake City
UT
84109
Common
02/06/2024
5665
45489.95
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 12/06/2021 through 09/08/2022.
03/25/2024
12/15/2023
/s/ John Boniface