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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001462808</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001628171</issuerCik>
            <issuerName>Revolution Medicines, Inc.</issuerName>
            <secFileNumber>001-39219</secFileNumber>
            <issuerAddress>
                <ns2:street1>700 Saginaw Drive </ns2:street1>
                <ns2:city>Redwood City</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94063</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6504816801</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEPHEN M. KELSEY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>16667</noOfUnitsSold>
            <aggregateMarketValue>636846.07</aggregateMarketValue>
            <noOfUnitsOutstanding>164986227</noOfUnitsOutstanding>
            <approxSaleDate>06/24/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/24/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>16667</amountOfSecuritiesAcquired>
            <paymentDate>06/24/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEPHEN M. KELSEY</name>
                <address>
                    <ns2:street1>700 Saginaw Drive </ns2:street1>
                    <ns2:city>Redwood City</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94063</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/17/2024</saleDate>
            <amountOfSecuritiesSold>3349</amountOfSecuritiesSold>
            <grossProceeds>125209.06</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.</remarks>
        <noticeSignature>
            <noticeDate>06/24/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/14/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Stephen M Kelsey</signature>
        </noticeSignature>
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144
0001462808
XXXXXXXX
LIVE
0001628171
Revolution Medicines, Inc.
001-39219
700 Saginaw Drive
Redwood City
CA
94063
6504816801
STEPHEN M. KELSEY
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
16667
636846.07
164986227
06/24/2024
NASDAQ
Common
06/24/2024
Exercise of Stock Options
Issuer
N
16667
06/24/2024
Cash
N
STEPHEN M. KELSEY
700 Saginaw Drive
Redwood City
CA
94063
Common
06/17/2024
3349
125209.06
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
06/24/2024
03/14/2024
/s/ Stephen M Kelsey