<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001798998</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000927653</issuerCik>
      <issuerName>MCKESSON CORP</issuerName>
      <secFileNumber>001-13252</secFileNumber>
      <issuerAddress>
        <com:street1>6555 STATE HIGHWAY 161</com:street1>
        <com:city>IRVING</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>75039</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>972-446-4800</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Avila Nancy</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>491</noOfUnitsSold>
      <aggregateMarketValue>193640.58</aggregateMarketValue>
      <noOfUnitsOutstanding>135602262</noOfUnitsOutstanding>
      <approxSaleDate>05/26/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/24/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>491</amountOfSecuritiesAcquired>
      <paymentDate>05/24/2023</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Nancy Avila and Nancy Flores are one and the same person.</remarks>
    <noticeSignature>
      <noticeDate>05/26/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>02/21/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Nancy Flores</signature>
    </noticeSignature>
  </formData>
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144
0001798998
XXXXXXXX
LIVE
0000927653
MCKESSON CORP
001-13252
6555 STATE HIGHWAY 161
IRVING
TX
75039
972-446-4800
Avila Nancy
Officer
Common
Fidelity Brokerage Services LLC
900 Salem Street
Smithfield
RI
02917
491
193640.58
135602262
05/26/2023
NYSE
Common
05/24/2023
Restricted Stock Vesting
Issuer
N
491
05/24/2023
Compensation
Y
Nancy Avila and Nancy Flores are one and the same person.
05/26/2023
02/21/2023
/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Nancy Flores