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            <filer>
                <filerCredentials>
                    <cik>0001267487</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
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    <formData>
        <issuerInfo>
            <issuerCik>0001804591</issuerCik>
            <issuerName>23ANDME HOLDING CO </issuerName>
            <secFileNumber>001-39587</secFileNumber>
            <issuerAddress>
                <ns2:street1>349 Oyster Point Boulevard  </ns2:street1>
                <ns2:city>South San Francisco</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>650-938-6300</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KATHY L HIBBS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>192743</noOfUnitsSold>
            <aggregateMarketValue>100014.34</aggregateMarketValue>
            <noOfUnitsOutstanding>315436358</noOfUnitsOutstanding>
            <approxSaleDate>03/07/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/07/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>192743</amountOfSecuritiesAcquired>
            <paymentDate>03/07/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for KATHY L HIBBS</name>
                <address>
                    <ns2:street1>349 Oyster Point Boulevard  </ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>02/22/2024</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>23325.39</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for KATHY L HIBBS</name>
                <address>
                    <ns2:street1>349 Oyster Point Boulevard  </ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>02/15/2024</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>30210.07</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for KATHY L HIBBS</name>
                <address>
                    <ns2:street1>349 Oyster Point Boulevard  </ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>01/25/2024</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>27997.41</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for KATHY L HIBBS</name>
                <address>
                    <ns2:street1>349 Oyster Point Boulevard  </ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>01/11/2024</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>27581.09</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for KATHY L HIBBS</name>
                <address>
                    <ns2:street1>349 Oyster Point Boulevard  </ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>12/28/2023</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>35904.55</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales Plan for KATHY L HIBBS</name>
                <address>
                    <ns2:street1>349 Oyster Point Boulevard  </ns2:street1>
                    <ns2:city>South San Francisco</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <saleDate>12/14/2023</saleDate>
            <amountOfSecuritiesSold>38548</amountOfSecuritiesSold>
            <grossProceeds>37221.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months.
</remarks>
        <noticeSignature>
            <noticeDate>03/07/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>03/09/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Kathy L Hibbs</signature>
        </noticeSignature>
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144
0001267487
XXXXXXXX
LIVE
0001804591
23ANDME HOLDING CO
001-39587
349 Oyster Point Boulevard
South San Francisco
CA
94080
650-938-6300
KATHY L HIBBS
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
192743
100014.34
315436358
03/07/2024
NASDAQ
Common
03/07/2024
Exercise of Stock Options
Issuer
N
192743
03/07/2024
Cash
N
10b5-1 Sales Plan for KATHY L HIBBS
349 Oyster Point Boulevard
South San Francisco
CA
94080
COMMON
02/22/2024
38548
23325.39
10b5-1 Sales Plan for KATHY L HIBBS
349 Oyster Point Boulevard
South San Francisco
CA
94080
COMMON
02/15/2024
38548
30210.07
10b5-1 Sales Plan for KATHY L HIBBS
349 Oyster Point Boulevard
South San Francisco
CA
94080
COMMON
01/25/2024
38548
27997.41
10b5-1 Sales Plan for KATHY L HIBBS
349 Oyster Point Boulevard
South San Francisco
CA
94080
COMMON
01/11/2024
38548
27581.09
10b5-1 Sales Plan for KATHY L HIBBS
349 Oyster Point Boulevard
South San Francisco
CA
94080
COMMON
12/28/2023
38548
35904.55
10b5-1 Sales Plan for KATHY L HIBBS
349 Oyster Point Boulevard
South San Francisco
CA
94080
COMMON
12/14/2023
38548
37221.00
The securities to be sold were and will be received upon the exercise of stock options over the next three months.
03/07/2024
03/09/2023
/s/ Kathy L Hibbs