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      <liveTestFlag>LIVE</liveTestFlag>


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      <issuerName>Cboe Global Markets, Inc.</issuerName>
      <secFileNumber>001-34774</secFileNumber>
      <issuerAddress>
        <com:street1>433 WEST VAN BUREN STREET</com:street1>
        <com:city>CHICAGO</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60607</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>312 786 7200</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>RATTERMAN JOSEPH P</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>245 summer street</com:street1>
          <com:city>boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>15000</noOfUnitsSold>
      <aggregateMarketValue>2052500.00</aggregateMarketValue>
      <noOfUnitsOutstanding>105574464</noOfUnitsOutstanding>
      <approxSaleDate>05/24/2023</approxSaleDate>
      <securitiesExchangeName>Other</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
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    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
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      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
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    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
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      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
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      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
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      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/01/2016</acquiredDate>
      <natureOfAcquisitionTransaction>stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>CBOE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6184</amountOfSecuritiesAcquired>
      <paymentDate>12/01/2016</paymentDate>
      <natureOfPayment>compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>shares being sold from JOSEPH &amp; SANDRA RATTERMAN TRUST</remarks>
    <noticeSignature>
      <noticeDate>05/24/2023</noticeDate>
      <signature>/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Joseph Ratterman</signature>
    </noticeSignature>
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144
0001163949
XXXXXXXX
LIVE
0001374310
Cboe Global Markets, Inc.
001-34774
433 WEST VAN BUREN STREET
CHICAGO
IL
60607
312 786 7200
RATTERMAN JOSEPH P
Director
common
Fidelity Brokerage Services LLC
245 summer street
boston
MA
02110
15000
2052500.00
105574464
05/24/2023
Other
Common
12/01/2016
stock award
CBOE
N
6184
12/01/2016
compensation
Common
12/01/2016
stock award
CBOE
N
6184
12/01/2016
compensation
Common
12/01/2016
stock award
CBOE
N
6184
12/01/2016
compensation
Common
12/01/2016
stock award
CBOE
N
6184
12/01/2016
compensation
Common
12/01/2016
stock award
CBOE
N
6184
12/01/2016
compensation
Common
12/01/2016
stock award
CBOE
N
6184
12/01/2016
compensation
Common
12/01/2016
stock award
CBOE
N
6184
12/01/2016
compensation
Common
12/01/2016
stock award
CBOE
N
6184
12/01/2016
compensation
Y
shares being sold from JOSEPH & SANDRA RATTERMAN TRUST
05/24/2023
/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Joseph Ratterman