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      <issuerCik>0000350698</issuerCik>
      <issuerName>AUTONATION, INC.</issuerName>
      <secFileNumber>001-13107</secFileNumber>
      <issuerAddress>
        <com:street1>200 SW 1ST AVE</com:street1>
        <com:street2>SUITE 1600</com:street2>
        <com:city>FORT LAUDERDALE</com:city>
        <com:stateOrCountry>FL</com:stateOrCountry>
        <com:zipCode>33301</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>9547696000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Mikan George Lawrence III</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Wells Fargo Clearing Services</name>
        <address>
          <com:street1>1 North Jefferson Avenue</com:street1>
          <com:city>St. Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63103</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>16771</noOfUnitsSold>
      <aggregateMarketValue>2675585.98</aggregateMarketValue>
      <noOfUnitsOutstanding>44047628</noOfUnitsOutstanding>
      <approxSaleDate>08/21/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
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      <securitiesClassTitle>common</securitiesClassTitle>
      <acquiredDate>02/01/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Settlement of a stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>9837</amountOfSecuritiesAcquired>
      <paymentDate>02/01/2022</paymentDate>
      <natureOfPayment>compensatory payment</natureOfPayment>
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      <securitiesClassTitle>common</securitiesClassTitle>
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      <natureOfAcquisitionTransaction>Settlement of a stock award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6934</amountOfSecuritiesAcquired>
      <paymentDate>02/01/2023</paymentDate>
      <natureOfPayment>compensatory payment</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>08/21/2023</noticeDate>
      <signature>George Lawrence Mikan III</signature>
    </noticeSignature>
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144
0001381037
XXXXXXXX
LIVE
0000350698
AUTONATION, INC.
001-13107
200 SW 1ST AVE
SUITE 1600
FORT LAUDERDALE
FL
33301
9547696000
Mikan George Lawrence III
Director
common
Wells Fargo Clearing Services
1 North Jefferson Avenue
St. Louis
MO
63103
16771
2675585.98
44047628
08/21/2023
NYSE
common
02/01/2022
Settlement of a stock award
Issuer
N
9837
02/01/2022
compensatory payment
common
02/01/2023
Settlement of a stock award
Issuer
N
6934
02/01/2023
compensatory payment
Y
08/21/2023
George Lawrence Mikan III