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      <filer>
        <filerCredentials>
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          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
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      <liveTestFlag>LIVE</liveTestFlag>



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  <formData>
    <issuerInfo>
      <issuerCik>0001068851</issuerCik>
      <issuerName>PROSPERITY BANCSHARES INC</issuerName>
      <secFileNumber>001-35388</secFileNumber>
      <issuerAddress>
        <com:street1>4295 SAN FELIPE</com:street1>
        <com:street2>N/A</com:street2>
        <com:city>HOUSTON</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>77027</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>7136939300</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Henderson Leah</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab Corp.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1100</noOfUnitsSold>
      <aggregateMarketValue>91586.00</aggregateMarketValue>
      <noOfUnitsOutstanding>95264666</noOfUnitsOutstanding>
      <approxSaleDate>11/18/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>04/20/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Vested RSUs</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1100</amountOfSecuritiesAcquired>
      <paymentDate>04/20/2021</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>11/18/2024</noticeDate>
      <signature>Leah B Henderson</signature>
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144
0001397178
XXXXXXXX
LIVE
0001068851
PROSPERITY BANCSHARES INC
001-35388
4295 SAN FELIPE
N/A
HOUSTON
TX
77027
7136939300
Henderson Leah
Director
Common
Charles Schwab Corp.
3000 Schwab Way
Westlake
TX
76262
1100
91586.00
95264666
11/18/2024
NYSE
Common
04/20/2021
Vested RSUs
Issuer
N
1100
04/20/2021
Equity Compensation
Y
11/18/2024
Leah B Henderson