<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
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            <filer>
                <filerCredentials>
                    <cik>0001421563</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001534969</issuerCik>
            <issuerName>SERA PROGNOSTICS, INC.</issuerName>
            <secFileNumber>001-40606</secFileNumber>
            <issuerAddress>
                <ns2:street1>2749 East Parleys Way, Suite 200</ns2:street1>
                <ns2:city>Salt Lake City</ns2:city>
                <ns2:stateOrCountry>UT</ns2:stateOrCountry>
                <ns2:zipCode>84109</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(801) 990-0520</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ROBERT HARRISON</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>5000</noOfUnitsSold>
            <aggregateMarketValue>16164.50</aggregateMarketValue>
            <noOfUnitsOutstanding>31052102</noOfUnitsOutstanding>
            <approxSaleDate>06/05/2023</approxSaleDate>
            <securitiesExchangeName>NASD</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common Stock</securitiesClassTitle>
            <acquiredDate>05/31/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5000</amountOfSecuritiesAcquired>
            <paymentDate>05/31/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/05/2023</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Robert Gardner Harrison</signature>
        </noticeSignature>
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144
0001421563
XXXXXXXX
LIVE
0001534969
SERA PROGNOSTICS, INC.
001-40606
2749 East Parleys Way, Suite 200
Salt Lake City
UT
84109
(801) 990-0520
ROBERT HARRISON
Officer
Common
Morgan Stanley Smith Barney LLC
1 New York Plaza
38th Floor
New York
NY
10004
5000
16164.50
31052102
06/05/2023
NASD
Common Stock
05/31/2023
Employee Stock Purchase Plan
Issuer
N
5000
05/31/2023
Cash
Y
06/05/2023
/s/ Robert Gardner Harrison