<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001359098</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001093557</issuerCik>
            <issuerName>DEXCOM, INC.</issuerName>
            <secFileNumber>000-51222</secFileNumber>
            <issuerAddress>
                <ns2:street1>6340 Sequence Drive</ns2:street1>
                <ns2:city>San Diego</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>92121</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(858) 200-0200</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEVEN PACELLI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>E*TRADE FINANCIAL CORPORATION</name>
                <address>
                    <ns2:street1>3 EDISON DRIVE</ns2:street1>
                    <ns2:city>ALPHARETTA</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30005</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>411</noOfUnitsSold>
            <aggregateMarketValue>43989.33</aggregateMarketValue>
            <noOfUnitsOutstanding>387871796</noOfUnitsOutstanding>
            <approxSaleDate>08/23/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <acquiredDate>09/08/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>411</amountOfSecuritiesAcquired>
            <paymentDate>09/08/2021</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN PACELLI</name>
                <address>
                    <ns2:street1>6340 Sequence Drive</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/24/2023</saleDate>
            <amountOfSecuritiesSold>412</amountOfSecuritiesSold>
            <grossProceeds>53798.96</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN PACELLI</name>
                <address>
                    <ns2:street1>6340 Sequence Drive</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/14/2023</saleDate>
            <amountOfSecuritiesSold>5031</amountOfSecuritiesSold>
            <grossProceeds>684216.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>STEVEN PACELLI</name>
                <address>
                    <ns2:street1>6340 Sequence Drive</ns2:street1>
                    <ns2:city>San Diego</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>92121</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/23/2023</saleDate>
            <amountOfSecuritiesSold>412</amountOfSecuritiesSold>
            <grossProceeds>51879.04</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>08/23/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/15/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Steven R Pacelli</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001359098
XXXXXXXX
LIVE
0001093557
DEXCOM, INC.
000-51222
6340 Sequence Drive
San Diego
CA
92121
(858) 200-0200
STEVEN PACELLI
Officer
Common
E*TRADE FINANCIAL CORPORATION
3 EDISON DRIVE
ALPHARETTA
GA
30005
411
43989.33
387871796
08/23/2023
NASDAQ
COMMON
09/08/2021
Restricted Stock
ISSUER
N
411
09/08/2021
Not Applicable
N
STEVEN PACELLI
6340 Sequence Drive
San Diego
CA
92121
Common
07/24/2023
412
53798.96
STEVEN PACELLI
6340 Sequence Drive
San Diego
CA
92121
Common
07/14/2023
5031
684216.00
STEVEN PACELLI
6340 Sequence Drive
San Diego
CA
92121
Common
06/23/2023
412
51879.04
08/23/2023
09/15/2022
/s/ Steven R Pacelli