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        <ns2:filerInfo>
            <ns2:filer>
                <ns2:filerCredentials>
                    <ns2:cik>0001611681</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
                </ns2:filerCredentials>
            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



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    </ns2:headerData>
    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0001402436</ns2:issuerCik>
            <ns2:issuerName>SS&amp;C Technologies Holdings, Inc.</ns2:issuerName>
            <ns2:secFileNumber>001-34675</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>80 Lamberton Road</com:street1>
                <com:city>Windsor</com:city>
                <com:stateOrCountry>CT</com:stateOrCountry>
                <com:zipCode>06095</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>1-860-298-4500</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Michael Zamkow</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Director</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>12500</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>995750</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>246662398</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>05/13/2025</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>11/17/2018</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from public market</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Public Market</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>6100</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>11/17/2018</ns2:paymentDate>
            <ns2:natureOfPayment>Cash</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:acquiredDate>02/19/2016</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Acquired from public market</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>Public Market</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>6400</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>02/19/2016</ns2:paymentDate>
            <ns2:natureOfPayment>Cash</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Michael Zamkow</ns2:name>
                <ns2:address>
                    <com:street1>80 Lamberton Road</com:street1>
                    <com:city>Windsor</com:city>
                    <com:stateOrCountry>CT</com:stateOrCountry>
                    <com:zipCode>06095</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>02/25/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>23000</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>2033151.7</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Michael Zamkow</ns2:name>
                <ns2:address>
                    <com:street1>80 Lamberton Road</com:street1>
                    <com:city>Windsor</com:city>
                    <com:stateOrCountry>CT</com:stateOrCountry>
                    <com:zipCode>06095</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common</ns2:securitiesClassTitle>
            <ns2:saleDate>05/02/2025</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>12900</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>1000260.1</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:noticeSignature>
            <ns2:noticeDate>05/13/2025</ns2:noticeDate>
            <ns2:planAdoptionDates/>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of Michael Zamkow</ns2:signature>
        </ns2:noticeSignature>
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144
0001611681
XXXXXXXX
LIVE
0001402436
SS&C Technologies Holdings, Inc.
001-34675
80 Lamberton Road
Windsor
CT
06095
1-860-298-4500
Michael Zamkow
Director
Common
Goldman Sachs & Co. LLC
200 West Street
New York
NY
10282
12500
995750
246662398
05/13/2025
NASD
Common
11/17/2018
Acquired from public market
Public Market
N
6100
11/17/2018
Cash
Common
02/19/2016
Acquired from public market
Public Market
N
6400
02/19/2016
Cash
N
Michael Zamkow
80 Lamberton Road
Windsor
CT
06095
Common
02/25/2025
23000
2033151.7
Michael Zamkow
80 Lamberton Road
Windsor
CT
06095
Common
05/02/2025
12900
1000260.1
05/13/2025
Goldman Sachs & Co. LLC on behalf of Michael Zamkow