<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
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        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0002010019</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001604821</issuerCik>
            <issuerName>NATERA, INC.</issuerName>
            <secFileNumber>001-37478</secFileNumber>
            <issuerAddress>
                <ns2:street1>13011 McCallen Pass</ns2:street1>
                <ns2:street2>Building A Suite 100</ns2:street2>
                <ns2:city>Austin</ns2:city>
                <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                <ns2:zipCode>78753</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 980-9190</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SOLOMON MOSHKEVICH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>3000</noOfUnitsSold>
            <aggregateMarketValue>421428.00</aggregateMarketValue>
            <noOfUnitsOutstanding>135186184</noOfUnitsOutstanding>
            <approxSaleDate>04/01/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/16/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>3000</amountOfSecuritiesAcquired>
            <paymentDate>01/16/2025</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SOLOMON MOSHKEVICH</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/17/2025</saleDate>
            <amountOfSecuritiesSold>1026</amountOfSecuritiesSold>
            <grossProceeds>149835.56</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SOLOMON MOSHKEVICH</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/05/2025</saleDate>
            <amountOfSecuritiesSold>745</amountOfSecuritiesSold>
            <grossProceeds>106750.31</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SOLOMON MOSHKEVICH</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/05/2025</saleDate>
            <amountOfSecuritiesSold>5255</amountOfSecuritiesSold>
            <grossProceeds>752983.70</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SOLOMON MOSHKEVICH</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>02/06/2025</saleDate>
            <amountOfSecuritiesSold>1632</amountOfSecuritiesSold>
            <grossProceeds>290120.64</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SOLOMON MOSHKEVICH</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/29/2025</saleDate>
            <amountOfSecuritiesSold>5201</amountOfSecuritiesSold>
            <grossProceeds>862687.58</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>SOLOMON MOSHKEVICH</name>
                <address>
                    <ns2:street1>13011 McCallen Pass</ns2:street1>
                    <ns2:street2>Building A Suite 100</ns2:street2>
                    <ns2:city>Austin</ns2:city>
                    <ns2:stateOrCountry>TX</ns2:stateOrCountry>
                    <ns2:zipCode>78753</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/22/2025</saleDate>
            <amountOfSecuritiesSold>24861</amountOfSecuritiesSold>
            <grossProceeds>4101226.46</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/01/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>11/26/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Solomon Moshkevich</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0002010019
XXXXXXXX
LIVE
0001604821
NATERA, INC.
001-37478
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
(650) 980-9190
SOLOMON MOSHKEVICH
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
3000
421428.00
135186184
04/01/2025
NASDAQ
Common
01/16/2025
Performance Shares
Issuer
N
3000
01/16/2025
Not Applicable
N
SOLOMON MOSHKEVICH
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
03/17/2025
1026
149835.56
SOLOMON MOSHKEVICH
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
03/05/2025
745
106750.31
SOLOMON MOSHKEVICH
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
03/05/2025
5255
752983.70
SOLOMON MOSHKEVICH
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
02/06/2025
1632
290120.64
SOLOMON MOSHKEVICH
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
01/29/2025
5201
862687.58
SOLOMON MOSHKEVICH
13011 McCallen Pass
Building A Suite 100
Austin
TX
78753
Common
01/22/2025
24861
4101226.46
04/01/2025
11/26/2024
/s/ Solomon Moshkevich