<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001453970</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0000354950</issuerCik>
            <issuerName>THE HOME DEPOT, INC.</issuerName>
            <secFileNumber>001-08207</secFileNumber>
            <issuerAddress>
                <ns2:street1>2455 Paces Ferry Road</ns2:street1>
                <ns2:city>Atlanta</ns2:city>
                <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                <ns2:zipCode>30339</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(770) 433-8211</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>THE ANN M AND CHRIS CAMPBELL CRUT</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>100</noOfUnitsSold>
            <aggregateMarketValue>40258.00</aggregateMarketValue>
            <noOfUnitsOutstanding>993362612</noOfUnitsOutstanding>
            <approxSaleDate>11/20/2024</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/16/2000</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>100</amountOfSecuritiesAcquired>
            <paymentDate>11/16/2000</paymentDate>
            <natureOfPayment>Services Rendered</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Ann Marie Campbell</name>
                <address>
                    <ns2:street1>2455 Paces Ferry Road</ns2:street1>
                    <ns2:city>Atlanta</ns2:city>
                    <ns2:stateOrCountry>GA</ns2:stateOrCountry>
                    <ns2:zipCode>30339</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>stock option</securitiesClassTitle>
            <saleDate>11/14/2024</saleDate>
            <amountOfSecuritiesSold>29968</amountOfSecuritiesSold>
            <grossProceeds>12239711.39</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>11/20/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Ann-Marie Campbell</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001453970
XXXXXXXX
LIVE
0000354950
THE HOME DEPOT, INC.
001-08207
2455 Paces Ferry Road
Atlanta
GA
30339
(770) 433-8211
THE ANN M AND CHRIS CAMPBELL CRUT
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
100
40258.00
993362612
11/20/2024
NYSE
Common
11/16/2000
Restricted stock vesting under a registered plan
Issuer
N
100
11/16/2000
Services Rendered
N
Ann Marie Campbell
2455 Paces Ferry Road
Atlanta
GA
30339
stock option
11/14/2024
29968
12239711.39
11/20/2024
/s/ Ann-Marie Campbell