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                    <ccc>XXXXXXXX</ccc>
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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001812364</issuerCik>
            <issuerName>RELAY THERAPEUTICS, INC.</issuerName>
            <secFileNumber>001-39385</secFileNumber>
            <issuerAddress>
                <ns2:street1>399 Binney Street</ns2:street1>
                <ns2:city>Cambridge</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02142</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(617)  370-8837</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>THOMAS J CATINAZZO</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
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        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>4566</noOfUnitsSold>
            <aggregateMarketValue>12967.44</aggregateMarketValue>
            <noOfUnitsOutstanding>169521849</noOfUnitsOutstanding>
            <approxSaleDate>03/27/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/26/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>698</amountOfSecuritiesAcquired>
            <paymentDate>12/26/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>07/27/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>257</amountOfSecuritiesAcquired>
            <paymentDate>07/27/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/27/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1262</amountOfSecuritiesAcquired>
            <paymentDate>01/27/2025</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/26/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>32</amountOfSecuritiesAcquired>
            <paymentDate>09/26/2023</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>10/27/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1727</amountOfSecuritiesAcquired>
            <paymentDate>10/27/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/26/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>590</amountOfSecuritiesAcquired>
            <paymentDate>03/26/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>THOMAS J CATINAZZO</name>
                <address>
                    <ns2:street1>399 Binney Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02142</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/30/2025</saleDate>
            <amountOfSecuritiesSold>20791</amountOfSecuritiesSold>
            <grossProceeds>91912.06</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>THOMAS J CATINAZZO</name>
                <address>
                    <ns2:street1>399 Binney Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02142</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/29/2025</saleDate>
            <amountOfSecuritiesSold>2109</amountOfSecuritiesSold>
            <grossProceeds>9595.95</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>THOMAS J CATINAZZO</name>
                <address>
                    <ns2:street1>399 Binney Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02142</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/28/2025</saleDate>
            <amountOfSecuritiesSold>33753</amountOfSecuritiesSold>
            <grossProceeds>156295.19</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>THOMAS J CATINAZZO</name>
                <address>
                    <ns2:street1>399 Binney Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02142</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/28/2025</saleDate>
            <amountOfSecuritiesSold>156</amountOfSecuritiesSold>
            <grossProceeds>722.28</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>THOMAS J CATINAZZO</name>
                <address>
                    <ns2:street1>399 Binney Street</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02142</ns2:zipCode>
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            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/28/2025</saleDate>
            <amountOfSecuritiesSold>660</amountOfSecuritiesSold>
            <grossProceeds>3055.80</grossProceeds>
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        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>THOMAS J CATINAZZO</name>
                <address>
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                    <ns2:zipCode>02142</ns2:zipCode>
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            <saleDate>01/28/2025</saleDate>
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            <grossProceeds>6792.21</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>03/27/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>02/15/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Thomas Catinazzo</signature>
        </noticeSignature>
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144
0001818261
XXXXXXXX
LIVE
0001812364
RELAY THERAPEUTICS, INC.
001-39385
399 Binney Street
Cambridge
MA
02142
(617)  370-8837
THOMAS J CATINAZZO
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
4566
12967.44
169521849
03/27/2025
NASDAQ
Common
12/26/2023
Restricted Stock
ISSUER
N
698
12/26/2023
Not Applicable
Common
07/27/2024
Restricted Stock
ISSUER
N
257
07/27/2024
Not Applicable
Common
01/27/2025
Restricted Stock
ISSUER
N
1262
01/27/2025
Not Applicable
Common
09/26/2023
Restricted Stock
ISSUER
N
32
09/26/2023
Not Applicable
Common
10/27/2024
Restricted Stock
ISSUER
N
1727
10/27/2024
Not Applicable
Common
03/26/2024
Restricted Stock
ISSUER
N
590
03/26/2024
Not Applicable
N
THOMAS J CATINAZZO
399 Binney Street
Cambridge
MA
02142
Common
01/30/2025
20791
91912.06
THOMAS J CATINAZZO
399 Binney Street
Cambridge
MA
02142
Common
01/29/2025
2109
9595.95
THOMAS J CATINAZZO
399 Binney Street
Cambridge
MA
02142
Common
01/28/2025
33753
156295.19
THOMAS J CATINAZZO
399 Binney Street
Cambridge
MA
02142
Common
01/28/2025
156
722.28
THOMAS J CATINAZZO
399 Binney Street
Cambridge
MA
02142
Common
01/28/2025
660
3055.80
THOMAS J CATINAZZO
399 Binney Street
Cambridge
MA
02142
Common
01/28/2025
1467
6792.21
03/27/2025
02/15/2024
/s/ Thomas Catinazzo