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            <liveTestFlag>LIVE</liveTestFlag>



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            <issuerCik>0001805387</issuerCik>
            <issuerName>CEREVEL THERAPEUTICS HOLDINGS, INC.</issuerName>
            <secFileNumber>001-39311</secFileNumber>
            <issuerAddress>
                <ns2:street1>222 Jacobs Street</ns2:street1>
                <ns2:street2>Suite 200</ns2:street2>
                <ns2:city>Cambridge</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02141</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(844) 304-2048</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SCOTT AKAMINE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>10000</noOfUnitsSold>
            <aggregateMarketValue>413700.00</aggregateMarketValue>
            <noOfUnitsOutstanding>180278078</noOfUnitsOutstanding>
            <approxSaleDate>12/07/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/07/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
            <paymentDate>12/07/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <name>SCOTT AKAMINE</name>
                <address>
                    <ns2:street1>222 Jacobs Street</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02141</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/05/2023</saleDate>
            <amountOfSecuritiesSold>7500</amountOfSecuritiesSold>
            <grossProceeds>262500.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>12/07/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/04/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Scott Akamine</signature>
        </noticeSignature>
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144
0001816720
XXXXXXXX
LIVE
0001805387
CEREVEL THERAPEUTICS HOLDINGS, INC.
001-39311
222 Jacobs Street
Suite 200
Cambridge
MA
02141
(844) 304-2048
SCOTT AKAMINE
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Floor
New York
NY
10004
10000
413700.00
180278078
12/07/2023
NASDAQ
Common
12/07/2023
Stock Option Exercise
Issuer
N
10000
12/07/2023
Cash
N
SCOTT AKAMINE
222 Jacobs Street
Suite 200
Cambridge
MA
02141
Common
12/05/2023
7500
262500.00
12/07/2023
08/04/2023
/s/ Scott Akamine