<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001883821</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001556263</issuerCik>
            <issuerName>SYROS PHARMACEUTICALS, INC.</issuerName>
            <secFileNumber>001-37813</secFileNumber>
            <issuerAddress>
                <ns2:street1>35 Cambridge Park Drive</ns2:street1>
                <ns2:street2>4th Floor</ns2:street2>
                <ns2:city>Cambridge</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02140</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>671-744-1340</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JASON HAAS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>100000</noOfUnitsSold>
            <aggregateMarketValue>20310.00</aggregateMarketValue>
            <noOfUnitsOutstanding>26832457</noOfUnitsOutstanding>
            <approxSaleDate>11/18/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/10/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Open Market</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>35363</amountOfSecuritiesAcquired>
            <paymentDate>09/10/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/12/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Open Market</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>45344</amountOfSecuritiesAcquired>
            <paymentDate>09/12/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/11/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Open Market Purchase</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Open Market</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>19293</amountOfSecuritiesAcquired>
            <paymentDate>09/11/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>11/18/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Jason Haas</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001883821
XXXXXXXX
LIVE
0001556263
SYROS PHARMACEUTICALS, INC.
001-37813
35 Cambridge Park Drive
4th Floor
Cambridge
MA
02140
671-744-1340
JASON HAAS
Officer
Director
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
100000
20310.00
26832457
11/18/2024
NASDAQ
Common
09/10/2024
Open Market Purchase
Open Market
N
35363
09/10/2024
Cash
Common
09/12/2024
Open Market Purchase
Open Market
N
45344
09/12/2024
Cash
Common
09/11/2024
Open Market Purchase
Open Market
N
19293
09/11/2024
Cash
Y
11/18/2024
/s/ Jason Haas