<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001197203</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001101239</issuerCik>
            <issuerName>EQUINIX INC.</issuerName>
            <secFileNumber>001-40205</secFileNumber>
            <issuerAddress>
                <ns2:street1>ONE LAGOON DRIVE</ns2:street1>
                <ns2:city>REDWOOD CITY</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94065</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(650) 598-6000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KEITH D TAYLOR &amp; ELIZABETH A TAYLOR 2004 REV TRUST DTD 5/3/04</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>2500</noOfUnitsSold>
            <aggregateMarketValue>2079075.00</aggregateMarketValue>
            <noOfUnitsOutstanding>94944994</noOfUnitsOutstanding>
            <approxSaleDate>08/15/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/12/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>831</amountOfSecuritiesAcquired>
            <paymentDate>02/12/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/15/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>1649</amountOfSecuritiesAcquired>
            <paymentDate>01/15/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/15/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted stock vesting under a registered plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>20</amountOfSecuritiesAcquired>
            <paymentDate>02/15/2024</paymentDate>
            <natureOfPayment>Not Applicable</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>08/15/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Keith D Taylor</signature>
        </noticeSignature>
    </formData>
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144
0001197203
XXXXXXXX
LIVE
0001101239
EQUINIX INC.
001-40205
ONE LAGOON DRIVE
REDWOOD CITY
CA
94065
(650) 598-6000
KEITH D TAYLOR & ELIZABETH A TAYLOR 2004 REV TRUST DTD 5/3/04
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
2500
2079075.00
94944994
08/15/2024
NASDAQ
Common
02/12/2024
Restricted stock vesting under a registered plan
Issuer
N
831
02/12/2024
Not Applicable
Common
01/15/2024
Restricted stock vesting under a registered plan
Issuer
N
1649
01/15/2024
Not Applicable
Common
02/15/2024
Restricted stock vesting under a registered plan
Issuer
N
20
02/15/2024
Not Applicable
Y
08/15/2024
/s/ Keith D Taylor