<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001852129</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001061983</issuerCik>
            <issuerName>CYTOKINETICS, INCORPORATED</issuerName>
            <secFileNumber>000-50633</secFileNumber>
            <issuerAddress>
                <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94080</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6506243000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ANDREW CALLOS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>26771</noOfUnitsSold>
            <aggregateMarketValue>1177656.29</aggregateMarketValue>
            <noOfUnitsOutstanding>118410689</noOfUnitsOutstanding>
            <approxSaleDate>03/13/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>03/02/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>18493</amountOfSecuritiesAcquired>
            <paymentDate>03/02/2023</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/16/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Performance Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>5900</amountOfSecuritiesAcquired>
            <paymentDate>02/16/2022</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>11/30/2021</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>2378</amountOfSecuritiesAcquired>
            <paymentDate>11/30/2021</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ANDREW CALLOS</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/06/2025</saleDate>
            <amountOfSecuritiesSold>3341</amountOfSecuritiesSold>
            <grossProceeds>144565.07</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ANDREW CALLOS</name>
                <address>
                    <ns2:street1>350 OYSTER POINT BOULEVARD</ns2:street1>
                    <ns2:city>SOUTH SAN FRANCISCO</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94080</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/03/2025</saleDate>
            <amountOfSecuritiesSold>1114</amountOfSecuritiesSold>
            <grossProceeds>47768.32</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 03/02/2023 through 03/06/2024.
The securities to be sold were acquired upon the vesting of performance stock units during the period of 02/16/2022 through 12/03/2024.
The securities to be sold were acquired upon the vesting of an employee stock purchase plan during the period of 11/30/2021 through 11/30/2023.

</remarks>
        <noticeSignature>
            <noticeDate>03/13/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/12/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Andrew Callos</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
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144
0001852129
XXXXXXXX
LIVE
0001061983
CYTOKINETICS, INCORPORATED
000-50633
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
6506243000
ANDREW CALLOS
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
26771
1177656.29
118410689
03/13/2025
NASDAQ
Common
03/02/2023
Restricted Stock Units
Issuer
N
18493
03/02/2023
N/A
Common
02/16/2022
Performance Stock Units
Issuer
N
5900
02/16/2022
N/A
Common
11/30/2021
Employee Stock Purchase Plan
Issuer
N
2378
11/30/2021
Cash
N
ANDREW CALLOS
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
03/06/2025
3341
144565.07
ANDREW CALLOS
350 OYSTER POINT BOULEVARD
SOUTH SAN FRANCISCO
CA
94080
Common
03/03/2025
1114
47768.32
The securities to be sold were acquired upon the vesting of restricted stock units during the period of 03/02/2023 through 03/06/2024.
The securities to be sold were acquired upon the vesting of performance stock units during the period of 02/16/2022 through 12/03/2024.
The securities to be sold were acquired upon the vesting of an employee stock purchase plan during the period of 11/30/2021 through 11/30/2023.
03/13/2025
12/12/2024
/s/ Andrew Callos