<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001776196</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001157601</issuerCik>
            <issuerName>MADRIGAL PHARMACEUTICALS, INC.</issuerName>
            <secFileNumber>001-33277</secFileNumber>
            <issuerAddress>
                <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                <ns2:street2>Suite 200</ns2:street2>
                <ns2:city>West Conshohocken</ns2:city>
                <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                <ns2:zipCode>19428</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(267) 824-2827</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BRIAN J. LYNCH</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>17311</noOfUnitsSold>
            <aggregateMarketValue>4744856.63</aggregateMarketValue>
            <noOfUnitsOutstanding>21311526</noOfUnitsOutstanding>
            <approxSaleDate>06/14/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>06/14/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>17311</amountOfSecuritiesAcquired>
            <paymentDate>06/14/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2052</amountOfSecuritiesSold>
            <grossProceeds>570595.95</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2040</amountOfSecuritiesSold>
            <grossProceeds>576909.35</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2042</amountOfSecuritiesSold>
            <grossProceeds>575344.12</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>575540.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2052</amountOfSecuritiesSold>
            <grossProceeds>569733.29</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2038</amountOfSecuritiesSold>
            <grossProceeds>576083.91</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>575472.60</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>576500.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>564781.60</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>577290.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>750</amountOfSecuritiesSold>
            <grossProceeds>215414.33</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>573205.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>576062.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>574849.80</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>574013.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>572517.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>586</amountOfSecuritiesSold>
            <grossProceeds>164080.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>574460.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/13/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>575023.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/11/2024</saleDate>
            <amountOfSecuritiesSold>1852</amountOfSecuritiesSold>
            <grossProceeds>532254.61</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/11/2024</saleDate>
            <amountOfSecuritiesSold>1850</amountOfSecuritiesSold>
            <grossProceeds>535145.25</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/11/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>573006.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/11/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>573482.20</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/11/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>575638.60</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>1939</amountOfSecuritiesSold>
            <grossProceeds>465487.39</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>1941</amountOfSecuritiesSold>
            <grossProceeds>465248.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>1937</amountOfSecuritiesSold>
            <grossProceeds>464850.75</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>1935</amountOfSecuritiesSold>
            <grossProceeds>466249.09</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>2140</amountOfSecuritiesSold>
            <grossProceeds>513343.20</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>480721.20</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>479774.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>470000.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>1138</amountOfSecuritiesSold>
            <grossProceeds>266911.19</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>480199.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>BRIAN J. LYNCH</name>
                <address>
                    <ns2:street1>200 Barr Harbor Drive</ns2:street1>
                    <ns2:street2>Suite 200</ns2:street2>
                    <ns2:city>West Conshohocken</ns2:city>
                    <ns2:stateOrCountry>PA</ns2:stateOrCountry>
                    <ns2:zipCode>19428</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/06/2024</saleDate>
            <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
            <grossProceeds>480180.80</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>06/14/2024</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Brian Lynch</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
[{"type": "144", "sequence": "1", "filename": "primary_doc.xml", "secsgml_size_bytes": 29877}]
144
0001776196
XXXXXXXX
LIVE
0001157601
MADRIGAL PHARMACEUTICALS, INC.
001-33277
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
(267) 824-2827
BRIAN J. LYNCH
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
17311
4744856.63
21311526
06/14/2024
NASDAQ
Common
06/14/2024
Stock Option Exercise
Issuer
N
17311
06/14/2024
Cash
N
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2052
570595.95
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2040
576909.35
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2042
575344.12
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
575540.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2052
569733.29
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2038
576083.91
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
575472.60
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
576500.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
564781.60
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
577290.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
750
215414.33
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
573205.40
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
576062.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
574849.80
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
574013.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
572517.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
586
164080.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
574460.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/13/2024
2000
575023.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/11/2024
1852
532254.61
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/11/2024
1850
535145.25
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/11/2024
2000
573006.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/11/2024
2000
573482.20
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/11/2024
2000
575638.60
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
1939
465487.39
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
1941
465248.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
1937
464850.75
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
1935
466249.09
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
2140
513343.20
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
2000
480721.20
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
2000
479774.40
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
2000
470000.00
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
1138
266911.19
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
2000
480199.40
BRIAN J. LYNCH
200 Barr Harbor Drive
Suite 200
West Conshohocken
PA
19428
Common
06/06/2024
2000
480180.80
06/14/2024
/s/ Brian Lynch