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            <secFileNumber>001-39782</secFileNumber>
            <issuerAddress>
                <ns2:street1>5858 Horton Street, #455</ns2:street1>
                <ns2:city>Emeryville</ns2:city>
                <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                <ns2:zipCode>94608</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>5105052680</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Scott Bizily</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
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            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>38th Fl.</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
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            </brokerOrMarketmakerDetails>
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            <aggregateMarketValue>193672.89</aggregateMarketValue>
            <noOfUnitsOutstanding>33234357</noOfUnitsOutstanding>
            <approxSaleDate>04/21/2023</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>04/21/2023</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>9375</amountOfSecuritiesAcquired>
            <paymentDate>04/21/2023</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
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        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>05/01/2022</acquiredDate>
            <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>372</amountOfSecuritiesAcquired>
            <paymentDate>05/01/2022</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
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                <address>
                    <ns2:street1>5858 Horton Street, #455</ns2:street1>
                    <ns2:city>Emeryville</ns2:city>
                    <ns2:stateOrCountry>CA</ns2:stateOrCountry>
                    <ns2:zipCode>94608</ns2:zipCode>
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            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>03/01/2023</saleDate>
            <amountOfSecuritiesSold>2248</amountOfSecuritiesSold>
            <grossProceeds>43386.40</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>04/21/2023</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>10/13/2022</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Scott Bizily</signature>
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144
0001920738
XXXXXXXX
LIVE
0001650648
4D MOLECULAR THERAPEUTICS INC
001-39782
5858 Horton Street, #455
Emeryville
CA
94608
5105052680
Scott Bizily
Officer
COMMON
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
38th Fl.
New York
NY
10004
9747
193672.89
33234357
04/21/2023
NASDAQ
Common
04/21/2023
Exercise of Stock Options
Issuer
N
9375
04/21/2023
Cash
Common
05/01/2022
Employee Stock Purchase Plan
Issuer
N
372
05/01/2022
N/A
N
10b5-1 Sales Plan for SCOTT BIZILY
5858 Horton Street, #455
Emeryville
CA
94608
Common
03/01/2023
2248
43386.40
04/21/2023
10/13/2022
/s/ Scott Bizily