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                <filerCredentials>
                    <cik>0001983476</cik>
                    <ccc>XXXXXXXX</ccc>
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            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



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    <formData>
        <issuerInfo>
            <issuerCik>0001974640</issuerCik>
            <issuerName>APOGEE THERAPEUTICS INC</issuerName>
            <secFileNumber>001-41740</secFileNumber>
            <issuerAddress>
                <ns2:street1>221 Crescent St., Building 17</ns2:street1>
                <ns2:street2>Suite 102b</ns2:street2>
                <ns2:city>Waltham</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02453</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6503945230</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>CARL DAMBKOWSKI</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>18160</noOfUnitsSold>
            <aggregateMarketValue>878580.80</aggregateMarketValue>
            <noOfUnitsOutstanding>58513198</noOfUnitsOutstanding>
            <approxSaleDate>12/11/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/16/2022</acquiredDate>
            <natureOfAcquisitionTransaction>RSA</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10900</amountOfSecuritiesAcquired>
            <paymentDate>09/16/2022</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/11/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>7260</amountOfSecuritiesAcquired>
            <paymentDate>12/11/2024</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CARL L DAMBKOWSKI</name>
                <address>
                    <ns2:street1>221 Crescent St., Building 17</ns2:street1>
                    <ns2:street2>Suite 102b</ns2:street2>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02453</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>12/04/2024</saleDate>
            <amountOfSecuritiesSold>6665</amountOfSecuritiesSold>
            <grossProceeds>307056.55</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CARL L DAMBKOWSKI</name>
                <address>
                    <ns2:street1>221 Crescent St., Building 17</ns2:street1>
                    <ns2:street2>Suite 102b</ns2:street2>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02453</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/06/2024</saleDate>
            <amountOfSecuritiesSold>6665</amountOfSecuritiesSold>
            <grossProceeds>394044.86</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>10b5-1 Sales for CARL L DAMBKOWSKI</name>
                <address>
                    <ns2:street1>221 Crescent St., Building 17</ns2:street1>
                    <ns2:street2>Suite 102b</ns2:street2>
                    <ns2:city>Waltham</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02453</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>10/02/2024</saleDate>
            <amountOfSecuritiesSold>6665</amountOfSecuritiesSold>
            <grossProceeds>374932.83</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.

</remarks>
        <noticeSignature>
            <noticeDate>12/11/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>08/21/2024</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Carl Dambkowski</signature>
        </noticeSignature>
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144
0001983476
XXXXXXXX
LIVE
0001974640
APOGEE THERAPEUTICS INC
001-41740
221 Crescent St., Building 17
Suite 102b
Waltham
MA
02453
6503945230
CARL DAMBKOWSKI
Officer
Common
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
18160
878580.80
58513198
12/11/2024
NASDAQ
Common
09/16/2022
RSA
Issuer
N
10900
09/16/2022
N/A
Common
12/11/2024
Exercise of Stock Options
Issuer
N
7260
12/11/2024
Cash
N
10b5-1 Sales for CARL L DAMBKOWSKI
221 Crescent St., Building 17
Suite 102b
Waltham
MA
02453
Common
12/04/2024
6665
307056.55
10b5-1 Sales for CARL L DAMBKOWSKI
221 Crescent St., Building 17
Suite 102b
Waltham
MA
02453
Common
11/06/2024
6665
394044.86
10b5-1 Sales for CARL L DAMBKOWSKI
221 Crescent St., Building 17
Suite 102b
Waltham
MA
02453
Common
10/02/2024
6665
374932.83
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
12/11/2024
08/21/2024
/s/ Carl Dambkowski