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      <issuerCik>0001439222</issuerCik>
      <issuerName>AGIOS PHARMACEUTICALS, INC.</issuerName>
      <secFileNumber>001-36014</secFileNumber>
      <issuerAddress>
        <com:street1>88 SIDNEY STREET</com:street1>
        <com:city>CAMBRIDGE</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02139</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>617-649-8600</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jones Cecilia</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
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    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1761</noOfUnitsSold>
      <aggregateMarketValue>60596.00</aggregateMarketValue>
      <noOfUnitsOutstanding>57915199</noOfUnitsOutstanding>
      <approxSaleDate>06/24/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/24/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Vesting of Restricted Stock Units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1761</amountOfSecuritiesAcquired>
      <paymentDate>06/24/2025</paymentDate>
      <natureOfPayment>Not Applicable</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/24/2025</noticeDate>
      <signature>William Cook, attorney-in-fact for Cecilia Jones</signature>
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144
0001840056
XXXXXXXX
LIVE
0001439222
AGIOS PHARMACEUTICALS, INC.
001-36014
88 SIDNEY STREET
CAMBRIDGE
MA
02139
617-649-8600
Jones Cecilia
Officer
Common Stock
Morgan Stanley Smith Barney LLC Executive Financial Services
1 New York Plaza
8th Floor
New York
NY
10004
1761
60596.00
57915199
06/24/2025
Nasdaq
Common Stock
06/24/2025
Vesting of Restricted Stock Units
Issuer
N
1761
06/24/2025
Not Applicable
Y
06/24/2025
William Cook, attorney-in-fact for Cecilia Jones