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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM 8-K</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">CURRENT REPORT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Pursuant to Section 13 or 15(d) of
the Securities Exchange Act of 1934</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Date of Report (Date of earliest event
reported): April 30, 2012</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>ENTREMED, INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact Name of Registrant as Specified in
its Charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE ALIGN="CENTER" CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<TR>
    <TD STYLE="width: 33%; vertical-align: bottom; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 10pt; text-align: center"><U>DELAWARE<BR>
</U>(State or other jurisdiction of <BR>
incorporation or organization)</TD>
    <TD STYLE="width: 33%; vertical-align: bottom; padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>0-20713</U></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Commission File Number)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></TD>
    <TD STYLE="width: 33%; vertical-align: top; padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>58-1959440<BR>
        </U>(IRS Employer Identification</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">No.)</P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>9640 Medical Center Drive</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Rockville, Maryland</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">______________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of principal executive offices)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>20850</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">____________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Zip Code)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(240) 864-2600</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">_____________________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Registrant&rsquo;s telephone number, including
area code)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Not Applicable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Former name or former address, if changed
since last report)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">registrant under any of the following provisions:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Wingdings">o</FONT></TD><TD>Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Wingdings">o</FONT></TD><TD>Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Wingdings">o</FONT></TD><TD>Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-family: Wingdings">o</FONT></TD><TD>Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3.01. Notice of Delisting or Failure to Satisfy a Continued
Listing Rule or Standard; Transfer of Listing</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As previously reported, on November 22,
2011, EntreMed, Inc. (the &ldquo;Company&rdquo;) received a letter (the &ldquo;Letter&rdquo;) from the Listing Qualifications Staff
(the &ldquo;Staff&rdquo;) of the Nasdaq Stock Market (&ldquo;Nasdaq&rdquo;), notifying the Company that it did not comply with
Nasdaq Listing Rule 5550(b)(1) (the &ldquo;Rule&rdquo;), which requires the Company to maintain a minimum of $2.5 million in stockholders&rsquo;
equity for continued listing on the Nasdaq Capital Market if it does not otherwise meet the other requirements under the Nasdaq
Capital Market continued listing rules.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company submitted a plan to regain compliance
and, on February 3, 2012, was granted an extension until May 21, 2012 to evidence compliance with the Rule. The extension was contingent
on completion and shareholder approval of the strategic financing of convertible notes with an aggregate principal amount of $10
million, and warrants to purchase 1,739,132 shares of the Company&rsquo;s common stock (collectively, the &ldquo;Strategic Financing&rdquo;).
The Company held its 2012 annual meeting of stockholders on April 30, 2012, and at the meeting the Company&rsquo;s stockholders
approved the Strategic Financing. As of the date of this report, the Company believes it has regained compliance with the stockholders&rsquo;
equity requirement based upon stockholder approval of the Strategic Financing. Nasdaq will continue to monitor the Company&rsquo;s
ongoing compliance with the stockholders&rsquo; equity requirement and, if at the time of its periodic report for the quarter ending
June 30, 2012, the Company does not evidence compliance, then it may be subject to delisting, at which time the Company may appeal
the Nasdaq Staff&rsquo;s determination to a Nasdaq Hearings Panel.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;5.02. Departure of Directors or Certain Officers;
Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(e) The Company held its 2012 annual meeting
of stockholders (the &ldquo;Annual Meeting&rdquo;) on April 30, 2012. At the Annual Meeting, the Company&rsquo;s stockholders approved
the amendment to the Company&rsquo;s 2011 Long-Term Incentive Plan (the &ldquo;2011 Plan&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">Under the
amendment to the 2011 Plan, (i) the number of shares of Common Stock reserved for issuance increased from 835,341 to 1,730,000,
and (ii) the maximum number of shares of Common Stock that may be awarded to any one individual under the Plan from 250,000 to
750,000.</FONT> <FONT STYLE="font-size: 10pt">The Company&rsquo;s executive officers and directors are eligible to receive awards
under the 2011 Plan in accordance with the terms and conditions set forth therein. A copy of the 2011 Plan was filed with the Securities
and Exchange Commission on March 22, 2012 as Appendix A to the Company&rsquo;s Definitive Proxy Statement on Schedule&nbsp;14A
(the &ldquo;Proxy Statement&rdquo;) for the Annual Meeting and is incorporated herein by reference.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 5.07. Submission of Matters to a Vote of Security Holders.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">At the Annual Meeting, the Company&rsquo;s
stockholders considered and approved four proposals, each of which is described in more detail in the Proxy Statement. The following
is a brief description of each matter voted upon at the Annual Meeting, and the final voting results for each matter, including
the number of votes cast for or against each matter and the number of abstentions and broker non-votes with respect to each matter.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>Election of Directors</I>.&nbsp; Each
of Dr. Wei-Wu He, PhD and Mr. Dwight L. Bush were elected to serve as a member of the board of directors for a term expiring at
the annual meeting of stockholders to be held in 2015 and until his successor is duly elected and qualified, as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 70%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 35%; border-bottom: windowtext 1pt solid">Director</TD>
    <TD STYLE="width: 3%; font-weight: bold; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 15%; border-bottom: windowtext 1pt solid; text-align: center">&nbsp;FOR</TD>
    <TD STYLE="width: 3%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 20%; border-bottom: windowtext 1pt solid; text-align: center">&nbsp;WITHHELD</TD>
    <TD STYLE="width: 3%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 20%; border-bottom: windowtext 1pt solid; text-align: center">BROKER&nbsp;<BR> NON-VOTES</TD>
    <TD STYLE="width: 1%; font-weight: bold; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="padding-left: 10pt; text-indent: -10pt">Dr. Wei-Wu He, PhD</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">6,165,912</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">43,388</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">5,859,778</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-left: 10pt; text-indent: -10pt">Mr. Dwight L. Bush</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">6,157,679</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">51,621</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">5,859,778</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="font-size: 10pt"><I>Approval
of the conversion or exercise of the convertible notes or warrants issued in connection with Strategic Financing in January as
described in the Proxy Statement.</I></FONT> <FONT STYLE="font-size: 10pt">The stockholders voted to approve the conversion or
exercise of the convertible notes or warrants, as follows:</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 60%; border-collapse: collapse">
<TR STYLE="background-color: rgb(204,255,204)">
    <TD STYLE="width: 68%; vertical-align: top; padding-left: 10pt; text-indent: -10pt">FOR</TD>
    <TD STYLE="width: 5%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 25%; vertical-align: bottom; text-align: right">5,952,794</TD>
    <TD STYLE="width: 2%; vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt">AGAINST</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">245,763</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,255,204)">
    <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt">ABSTAIN</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">10,743</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt">BROKER NON-VOTES</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">5,859,778</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>Approval of the amendment to the 2011
Long-Term Incentive Plan. </I>The stockholders voted to approve the amendment to the 2011 Plan, as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 60%; border-collapse: collapse">
<TR STYLE="background-color: rgb(204,255,204)">
    <TD STYLE="width: 68%; vertical-align: top; padding-left: 10pt; text-indent: -10pt">FOR</TD>
    <TD STYLE="width: 5%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 25%; vertical-align: bottom; text-align: right">5,924,648</TD>
    <TD STYLE="width: 2%; vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt">AGAINST</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">269,238</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,255,204)">
    <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt">ABSTAIN</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">15,413</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt">BROKER NON-VOTES</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">5,859,779</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>Ratify Independent Registered Public
Accountants</I>.&nbsp; The stockholders ratified the appointment of Reznick Group, P.C. as the Company&rsquo;s independent registered
public accounting firm for the fiscal year ending December&nbsp;31, 2012, as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 60%; border-collapse: collapse">
<TR STYLE="background-color: rgb(204,255,204)">
    <TD STYLE="width: 68%; vertical-align: top; padding-left: 10pt; text-indent: -10pt">FOR</TD>
    <TD STYLE="width: 5%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 25%; vertical-align: bottom; text-align: right">11,947,204</TD>
    <TD STYLE="width: 2%; vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt">AGAINST</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">101,875</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,255,204)">
    <TD STYLE="vertical-align: top; padding-left: 10pt; text-indent: -10pt">ABSTAIN</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: right">19,999</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;9.01 Financial Statements and Exhibits.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(d)&nbsp;&nbsp; Exhibits</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in">10.1</TD><TD>EntreMed, Inc. 2011 Long-Term Incentive Plan, As Amended (previously filed with, and incorporated herein by reference to,
                                                                the Company&rsquo;s Definitive Proxy Statement filed on March, 22, 2012)&nbsp;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">ENTREMED, INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in"><U>/s/ Cynthia W. Hu</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">Cynthia W. Hu</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 5in">Chief Operating Officer, General Counsel &amp; Secretary</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 225.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date: May 4, 2012</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

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[{"type": "8-K", "sequence": "1", "filename": "v311903_8k.htm", "description": "FORM 8-K", "secsgml_size_bytes": 25606}]
{"company-data": {"conformed-name": "ENTREMED INC", "cik": "0000895051", "assigned-sic": "2836", "irs-number": "581959440", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-20713", "film-number": "12811838"}, "business-address": {"street1": "9640 MEDICAL CNTR DR", "street2": "STE 200", "city": "ROCKVILLE", "state": "MD", "zip": "20850", "phone": "3012179858"}, "mail-address": {"street1": "9640 MEDICAL CNTR SR", "street2": "STE 200", "city": "ROCKVILLE", "state": "MD", "zip": "20850"}}
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of
the Securities Exchange Act of 1934
Date of Report (Date of earliest event
reported): April 30, 2012
ENTREMED, INC.
(Exact Name of Registrant as Specified in
its Charter)
DELAWARE
(State or other jurisdiction of
incorporation or organization)
0-20713
(Commission File Number)
58-1959440
(IRS Employer Identification
No.)
9640 Medical Center Drive
Rockville, Maryland
______________________
(Address of principal executive offices)
20850
____________________
(Zip Code)
(240) 864-2600
_____________________
(Registrant's telephone number, including
area code)
Not Applicable
(Former name or former address, if changed
since last report)
Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the
registrant under any of the following provisions:
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 3.01. Notice of Delisting or Failure to Satisfy a Continued
Listing Rule or Standard; Transfer of Listing
As previously reported, on November 22,
2011, EntreMed, Inc. (the "Company") received a letter (the "Letter") from the Listing Qualifications Staff
(the "Staff") of the Nasdaq Stock Market ("Nasdaq"), notifying the Company that it did not comply with
Nasdaq Listing Rule 5550(b)(1) (the "Rule"), which requires the Company to maintain a minimum of $2.5 million in stockholders'
equity for continued listing on the Nasdaq Capital Market if it does not otherwise meet the other requirements under the Nasdaq
Capital Market continued listing rules.
The Company submitted a plan to regain compliance
and, on February 3, 2012, was granted an extension until May 21, 2012 to evidence compliance with the Rule. The extension was contingent
on completion and shareholder approval of the strategic financing of convertible notes with an aggregate principal amount of $10
million, and warrants to purchase 1,739,132 shares of the Company's common stock (collectively, the "Strategic Financing").
The Company held its 2012 annual meeting of stockholders on April 30, 2012, and at the meeting the Company's stockholders
approved the Strategic Financing. As of the date of this report, the Company believes it has regained compliance with the stockholders'
equity requirement based upon stockholder approval of the Strategic Financing. Nasdaq will continue to monitor the Company's
ongoing compliance with the stockholders' equity requirement and, if at the time of its periodic report for the quarter ending
June 30, 2012, the Company does not evidence compliance, then it may be subject to delisting, at which time the Company may appeal
the Nasdaq Staff's determination to a Nasdaq Hearings Panel.
Item 5.02. Departure of Directors or Certain Officers;
Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
(e) The Company held its 2012 annual meeting
of stockholders (the "Annual Meeting") on April 30, 2012. At the Annual Meeting, the Company's stockholders approved
the amendment to the Company's 2011 Long-Term Incentive Plan (the "2011 Plan").
Under the
amendment to the 2011 Plan, (i) the number of shares of Common Stock reserved for issuance increased from 835,341 to 1,730,000,
and (ii) the maximum number of shares of Common Stock that may be awarded to any one individual under the Plan from 250,000 to
750,000.
The Company's executive officers and directors are eligible to receive awards
under the 2011 Plan in accordance with the terms and conditions set forth therein. A copy of the 2011 Plan was filed with the Securities
and Exchange Commission on March 22, 2012 as Appendix A to the Company's Definitive Proxy Statement on Schedule 14A
(the "Proxy Statement") for the Annual Meeting and is incorporated herein by reference.
Item 5.07. Submission of Matters to a Vote of Security Holders.
At the Annual Meeting, the Company's
stockholders considered and approved four proposals, each of which is described in more detail in the Proxy Statement. The following
is a brief description of each matter voted upon at the Annual Meeting, and the final voting results for each matter, including
the number of votes cast for or against each matter and the number of abstentions and broker non-votes with respect to each matter.
Election of Directors
.  Each
of Dr. Wei-Wu He, PhD and Mr. Dwight L. Bush were elected to serve as a member of the board of directors for a term expiring at
the annual meeting of stockholders to be held in 2015 and until his successor is duly elected and qualified, as follows:
Director
FOR
WITHHELD
BROKER
NON-VOTES
Dr. Wei-Wu He, PhD
6,165,912
43,388
5,859,778
Mr. Dwight L. Bush
6,157,679
51,621
5,859,778
Approval
of the conversion or exercise of the convertible notes or warrants issued in connection with Strategic Financing in January as
described in the Proxy Statement.
The stockholders voted to approve the conversion or
exercise of the convertible notes or warrants, as follows:
FOR
5,952,794
AGAINST
245,763
ABSTAIN
10,743
BROKER NON-VOTES
5,859,778
Approval of the amendment to the 2011
Long-Term Incentive Plan.
The stockholders voted to approve the amendment to the 2011 Plan, as follows:
FOR
5,924,648
AGAINST
269,238
ABSTAIN
15,413
BROKER NON-VOTES
5,859,779
Ratify Independent Registered Public
Accountants
.  The stockholders ratified the appointment of Reznick Group, P.C. as the Company's independent registered
public accounting firm for the fiscal year ending December 31, 2012, as follows:
FOR
11,947,204
AGAINST
101,875
ABSTAIN
19,999
Item 9.01 Financial Statements and Exhibits.
(d)   Exhibits
10.1
EntreMed, Inc. 2011 Long-Term Incentive Plan, As Amended (previously filed with, and incorporated herein by reference to,
                                                                the Company's Definitive Proxy Statement filed on March, 22, 2012)
SIGNATURES
Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
ENTREMED, INC.
/s/ Cynthia W. Hu
Cynthia W. Hu
Chief Operating Officer, General Counsel & Secretary
Date: May 4, 2012