<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">UNITED STATES</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">SECURITIES AND EXCHANGE COMMISSION</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Washington, D.C. 20549</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><BR>
FORM 8-K</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><BR>
CURRENT REPORT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><BR>
Pursuant to Section 13 or 15(d) of the<BR>
Securities Exchange Act of 1934</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Date of Report (Date of earliest event reported)<BR>
June 5, 2012</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><BR>
HEMISPHERX BIOPHARMA, INC.<BR>
(Exact name of registrant as specified in its charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="width: 75%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 34%; padding-right: 0; padding-left: 0; text-align: center">Delaware</TD>
    <TD STYLE="width: 33%; padding-right: 0; padding-left: 0; text-align: center">0&#45;27072</TD>
    <TD STYLE="width: 33%; padding-right: 0; padding-left: 0; text-align: center">52-0845822</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center">(state or other juris-</TD>
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center">(Commission</TD>
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center">(I.R.S. Employer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center">diction of incorporation)</TD>
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center">File Number)</TD>
    <TD STYLE="padding-right: 0; padding-left: 0; text-align: center">(Identification No.)</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="width: 75%; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; padding-right: 0; padding-left: 0; font-size: 10pt; text-align: center">1617 JFK Boulevard, Philadelphia, Pennsylvania</TD>
    <TD STYLE="width: 50%; padding-right: 0; padding-left: 0; font-size: 10pt; text-align: center">19103</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0; padding-left: 0; font-size: 10pt; text-align: center">(Address of principal executive offices)</TD>
    <TD STYLE="padding-right: 0; padding-left: 0; font-size: 10pt; text-align: center">(Zip Code)</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Registrant's telephone number, including area code: (215) 988-0080</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<!-- Field: Rule-Page --><DIV ALIGN="CENTER" STYLE="margin-top: 3pt; margin-bottom: 3pt"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; width: 50%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Former name or former address, if changed
since last report)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction
A.2. below):</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT> Written communications pursuant to Rule 425 under the Securities
Act (17 CFR 230.425)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT> Soliciting material pursuant to Rule 14a-12 under the Exchange
Act (17 CFR 240.14a-12)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT> Pre-commencement communications pursuant to Rule 14d-2(b)
under the Exchange Act (17 CFR 240.14d-2(b))</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Wingdings">&#168;</FONT> Pre-commencement communications pursuant to Rule 13e-4(c)
under the Exchange Act (17 CFR 240.13e-4(c))</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<!-- Field: Page; Sequence: 1 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%"><TR><TD STYLE="text-align: left; width: 50%">&nbsp;</TD><TD STYLE="text-align: right; width: 50%"></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 5.02 Departure of Directors or Certain Officers; Election
of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">On June 5, 2012, our
Board of Directors (&ldquo;Board&rdquo;) and the Board&rsquo;s Compensation Committee (&ldquo;Compensation Committee&rdquo;) confirmed
their belief that long-term performance is achieved through an ownership culture that encourages such performance by the Company&rsquo;s
Directors, Officers and employees through the use of stock and stock-based awards as to align their interests to that of the stockholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">In furtherance of this
belief, the Board and Compensation Committee in recognition of the dedication and performance of Robert Dickey IV, Senior Vice
President and Chairman of Disclosure Controls Committee, and Wayne Springate, Senior Vice President of Operations, granted to each
50,000 Options to purchase shares of the Company common stock. Additionally, the Board and Compensation Committee recognizing that
the Board&rsquo;s commitment of time and effort has increased over time for the benefit of the Company as the demand for specific
expertise has grown and corporate governance issues require greater attention in a highly regulated environment, granted 100,000
Options to each current Directors to purchase Company common stock:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">William A. Carter: Chairman of the Board
and member of Disclosure Controls Committee;</FONT></TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Thomas K. Equels: Executive Vice Chairman
of the Board, Secretary and member of Disclosure Controls Committee</FONT>;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Richard Piani: Independent Director, Chairman
of Audit Committee</FONT>;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">William Mitchell: Independent
                                                                                                              Director, Chairman of Corporate Governance &amp; Nomination Committee and member of Disclosure Controls Committee; and</FONT></TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif">Iraj E. Kiani: Independent Director and
Chairman of Compensation Committee</FONT>.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Besides being a Chairman
of their respective committee, the Independent Directors serve as members of two of the following committees: Audit, Compensation
or Corporate Governance &amp; Nomination.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The Options identified
above were granted with an exercise price equal to 110% of the final closing price of the Company&rsquo;s common stock on the NYSE
MKT LLC as of June 5, 2012 ($0.26), will vest one year after issuance, contain a cashless exercise provision, have a ten year term
and were issued from the Company&rsquo;s 2009 Equity Incentive Plan.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">For the past five years,
Options issued to Officers and employees have contained cashless exercise provisions. That is, the holders of the Options have
the right to exercise the Options pursuant to a formula where they utilize the increase in the stock price over the exercise price
to pay the exercise price rather than pay cash. The Board and Compensation Committee recognized that some outstanding Options and
Warrants held by currently employed Officers and employees did not contain a cashless exercise provision. As a result, the Board
and Compensation Committee approved an amendment to these Options and Warrants to provide for cashless exercise. The following
Options and Warrants held by Named Executive Officers are affected by this change:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<!-- Field: Page; Sequence: 2; Options: NewSection; Value: 2 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt"><TR><TD STYLE="text-align: center; width: 100%"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="width: 26%; padding-right: 0; padding-left: 0; font-weight: bold; text-decoration: underline">Named Executive Officer</TD>
    <TD NOWRAP STYLE="width: 18%; padding-right: 0; padding-left: 0; font-weight: bold; text-decoration: underline">Instrument</TD>
    <TD NOWRAP STYLE="width: 10%; padding-right: 0; padding-left: 0; font-weight: bold; text-decoration: underline">Number</TD>
    <TD NOWRAP STYLE="width: 11%; padding-right: 0; padding-left: 0; font-weight: bold; text-decoration: underline; text-align: center">Issued</TD>
    <TD NOWRAP STYLE="width: 11%; padding-right: 0; padding-left: 0; font-weight: bold; text-decoration: underline; text-align: center">Expiration</TD>
    <TD NOWRAP STYLE="width: 12%; padding-right: 0; padding-left: 0; font-weight: bold; text-decoration: underline; text-align: center">Shares</TD>
    <TD NOWRAP STYLE="width: 12%; padding-right: 0; padding-left: 0; font-weight: bold; text-decoration: underline; text-align: center">Price</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">David Strayer</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">Option</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">04-12-28</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">12/7/2004</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">12/6/2014</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">10,000</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">&nbsp;$&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 1.90</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">William A. Carter</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">Option</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">06-01-312</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">12/9/2005</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">12/8/2015</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">10,000</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">&nbsp;$&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2.61</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">David Strayer</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">Option</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">06-01-30</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">12/9/2005</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">12/8/2015</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">10,000</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">&nbsp;$&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2.61</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">David Strayer</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">Option</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">06-12-18</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">11/20/2006</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">11/19/2016</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">15,000</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">&nbsp;$&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2.20</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">David Strayer</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">Option</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">07-12-01</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">12/7/2007</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">12/6/2017</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">25,000</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">&nbsp;$&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 1.30</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">Robert Dickey IV</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">Option</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">09-07-02</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">6/12/2009</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">6/11/2019</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">150,000</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">&nbsp;$&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2.81</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">William A. Carter</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">Stand-by Warrant</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">09-02-01</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">2/1/2009</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">1/31/2019</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">491,196</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">&nbsp;$&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 0.51</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">Thomas K. Equels</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">Stand-by Warrant</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0">09-02-02</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">2/1/2009</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">1/31/2019</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center"> 491,196</TD>
    <TD NOWRAP STYLE="padding-right: 0; padding-left: 0; text-align: center">&nbsp;$&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 0.51</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Item 8.01 Other Events. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">On June 5, 2012, the
Compensation Committee and the Corporate Governance &amp; Nomination Committee undertook the annual evaluation of their respective
charters and, accordingly, amended their charters to better reflect the duties and responsibilities of these Committees as well
as better reflect the current industry standard for such Committees. The revised charters are available on our website at http://www.hemispherx.net/content/investor/corp_governance.htm.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 9.01.&#9;Financial Statements and Exhibits.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: left; margin-bottom: 0pt; margin-left: 0.25in">(c) Exhibits:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 12%; padding-right: 0; padding-left: 0; text-align: center">4.1</TD>
    <TD STYLE="width: 88%; padding-right: 0; padding-left: 0">Form of Amendment to Officer and Employee Options and Warrants.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<!-- Field: Page; Sequence: 3; Value: 2 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt"><TR><TD STYLE="text-align: center; width: 100%"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --></TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">SIGNATURES</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the requirements of the Securities Exchange Act
of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0; margin-top: 0pt; margin-bottom: 6pt"></P>

<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2">HEMISPHERX BIOPHARMA, INC.</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 50%">June 8, 2012</TD>
    <TD STYLE="width: 4%">By:&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 46%">/s/ William A. Carter&#9;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-top: #000000 1px solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: left; margin-bottom: 0pt">William A. Carter M.D.,</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: left; margin-bottom: 0pt">Chief Executive Officer</P>
</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0pt; margin-top: 0pt; margin-bottom: 6pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0pt; margin-top: 0pt; margin-bottom: 6pt"></P>

<!-- Field: Page; Sequence: 4; Options: Last -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt"><TR><TD STYLE="text-align: center; width: 100%"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->4<!-- Field: /Sequence --></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; text-indent: 0pt; margin-top: 0pt; margin-bottom: 6pt"></P>

</BODY>
</HTML>
[{"type": "8-K", "sequence": "1", "filename": "v315624_8k.htm", "description": "FORM 8-K", "secsgml_size_bytes": 27048}]
{"company-data": {"conformed-name": "HEMISPHERX BIOPHARMA INC", "cik": "0000946644", "assigned-sic": "2836", "irs-number": "520845822", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-13441", "film-number": "12896880"}, "business-address": {"street1": "1617 JFK BLVD #660", "street2": "ONE PENN CENTER", "city": "PHILADELPHIA", "state": "PA", "zip": "19104", "phone": "2159880080"}, "mail-address": {"street1": "1617 JFK BLVD", "street2": "ONE PENN CENTER", "city": "PHILADELPHIA", "state": "PA", "zip": "19103"}}
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of Report (Date of earliest event reported)
June 5, 2012
HEMISPHERX BIOPHARMA, INC.
(Exact name of registrant as specified in its charter)
Delaware
0-27072
52-0845822
(state or other juris-
(Commission
(I.R.S. Employer
diction of incorporation)
File Number)
(Identification No.)
1617 JFK Boulevard, Philadelphia, Pennsylvania
19103
(Address of principal executive offices)
(Zip Code)
Registrant's telephone number, including area code: (215) 988-0080
(Former name or former address, if changed
since last report)
Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction
A.2. below):
¨
Written communications pursuant to Rule 425 under the Securities
Act (17 CFR 230.425)
¨
Soliciting material pursuant to Rule 14a-12 under the Exchange
Act (17 CFR 240.14a-12)
¨
Pre-commencement communications pursuant to Rule 14d-2(b)
under the Exchange Act (17 CFR 240.14d-2(b))
¨
Pre-commencement communications pursuant to Rule 13e-4(c)
under the Exchange Act (17 CFR 240.13e-4(c))
Item 5.02 Departure of Directors or Certain Officers; Election
of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
On June 5, 2012, our
Board of Directors ("Board") and the Board's Compensation Committee ("Compensation Committee") confirmed
their belief that long-term performance is achieved through an ownership culture that encourages such performance by the Company's
Directors, Officers and employees through the use of stock and stock-based awards as to align their interests to that of the stockholders.
In furtherance of this
belief, the Board and Compensation Committee in recognition of the dedication and performance of Robert Dickey IV, Senior Vice
President and Chairman of Disclosure Controls Committee, and Wayne Springate, Senior Vice President of Operations, granted to each
50,000 Options to purchase shares of the Company common stock. Additionally, the Board and Compensation Committee recognizing that
the Board's commitment of time and effort has increased over time for the benefit of the Company as the demand for specific
expertise has grown and corporate governance issues require greater attention in a highly regulated environment, granted 100,000
Options to each current Directors to purchase Company common stock:
·
William A. Carter: Chairman of the Board
and member of Disclosure Controls Committee;
·
Thomas K. Equels: Executive Vice Chairman
of the Board, Secretary and member of Disclosure Controls Committee
;
·
Richard Piani: Independent Director, Chairman
of Audit Committee
;
·
William Mitchell: Independent
                                                                                                              Director, Chairman of Corporate Governance & Nomination Committee and member of Disclosure Controls Committee; and
·
Iraj E. Kiani: Independent Director and
Chairman of Compensation Committee
.
Besides being a Chairman
of their respective committee, the Independent Directors serve as members of two of the following committees: Audit, Compensation
or Corporate Governance & Nomination.
The Options identified
above were granted with an exercise price equal to 110% of the final closing price of the Company's common stock on the NYSE
MKT LLC as of June 5, 2012 ($0.26), will vest one year after issuance, contain a cashless exercise provision, have a ten year term
and were issued from the Company's 2009 Equity Incentive Plan.
For the past five years,
Options issued to Officers and employees have contained cashless exercise provisions. That is, the holders of the Options have
the right to exercise the Options pursuant to a formula where they utilize the increase in the stock price over the exercise price
to pay the exercise price rather than pay cash. The Board and Compensation Committee recognized that some outstanding Options and
Warrants held by currently employed Officers and employees did not contain a cashless exercise provision. As a result, the Board
and Compensation Committee approved an amendment to these Options and Warrants to provide for cashless exercise. The following
Options and Warrants held by Named Executive Officers are affected by this change:
2
Named Executive Officer
Instrument
Number
Issued
Expiration
Shares
Price
David Strayer
Option
04-12-28
12/7/2004
12/6/2014
10,000
$       1.90
William A. Carter
Option
06-01-312
12/9/2005
12/8/2015
10,000
$       2.61
David Strayer
Option
06-01-30
12/9/2005
12/8/2015
10,000
$       2.61
David Strayer
Option
06-12-18
11/20/2006
11/19/2016
15,000
$       2.20
David Strayer
Option
07-12-01
12/7/2007
12/6/2017
25,000
$       1.30
Robert Dickey IV
Option
09-07-02
6/12/2009
6/11/2019
150,000
$       2.81
William A. Carter
Stand-by Warrant
09-02-01
2/1/2009
1/31/2019
491,196
$       0.51
Thomas K. Equels
Stand-by Warrant
09-02-02
2/1/2009
1/31/2019
491,196
$       0.51
Item 8.01 Other Events.
On June 5, 2012, the
Compensation Committee and the Corporate Governance & Nomination Committee undertook the annual evaluation of their respective
charters and, accordingly, amended their charters to better reflect the duties and responsibilities of these Committees as well
as better reflect the current industry standard for such Committees. The revised charters are available on our website at http://www.hemispherx.net/content/investor/corp_governance.htm.
Item 9.01.	Financial Statements and Exhibits.
(c) Exhibits:
4.1
Form of Amendment to Officer and Employee Options and Warrants.
3
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act
of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
HEMISPHERX BIOPHARMA, INC.
June 8, 2012
By:
/s/ William A. Carter
William A. Carter M.D.,
Chief Executive Officer
4