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<div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">UNITED STATES</font></div>

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<div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="center"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">9530 Main Street</font></div>

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<font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:</font></div>

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<div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font style="DISPLAY: inline;" face="Wingdings">o </font>Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</font><br>
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<div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-WEIGHT: bold; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Entry into a Material Definitive Agreement.</font></div>
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<div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; MARGIN-RIGHT: 0pt; TEXT-ALIGN: justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font style="DISPLAY: inline; FONT-SIZE: 10pt">On November 22, 2011, 22nd Century Limited, LLC (the &#8220;Company&#8221;) <font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">a wholly-owned subsidiary of 22nd Century Group, Inc.,</font> entered into a Letter Agreement (the &#8220;Letter Agreement&#8221;) with North Carolina State University (&#8220;NCSU&#8221;).&#160;&#160;The Letter Agreement provides that NCSU agreed to&#160;extend terms for (i) payments due and (ii) a peformance milestone under a license agreement&#160;effective as of March 6, 2009 between the Company and NCSU (the &#8220;License Agreement&#8221;). </font>In addition, the Company agreed to pay&#160;&#160;all outstanding amounts owed to NCSU on the earlier of (i) the closing of a capital raise of at least $5 million or (ii) October 15, 2012.</font></div>

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<div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</font></div>

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<td valign="top" width="35%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman"><font style="DISPLAY: inline; FONT-WEIGHT: bold">22nd Century Group, Inc.</font></font></td>
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<div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">Date:&#160;November 23, 2011</font></div>
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<td align="left" nowrap valign="top" width="35%" style="BORDER-BOTTOM: black 2px solid"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">/s/&#160;Joseph Pandolfino</font></td>
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<td align="left" nowrap valign="bottom" width="35%"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: times new roman">Joseph Pandolfino</font></td>
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[{"type": "8-K", "sequence": "1", "filename": "v241596_8k.htm", "description": "CURRENT REPORT ON FORM 8-K", "secsgml_size_bytes": 22824}]
{"company-data": {"conformed-name": "22nd Century Group, Inc.", "cik": "0001347858", "assigned-sic": "2111", "irs-number": "980468420", "state-of-incorporation": "NV", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-54111", "film-number": "111225298"}, "business-address": {"street1": "9530 MAIN STREET", "city": "CLARENCE,", "state": "NY", "zip": "14031", "phone": "716 270 1253"}, "mail-address": {"street1": "9530 MAIN STREET", "city": "CLARENCE,", "state": "NY", "zip": "14031"}, "former-company": {"former-conformed-name": "Touchstone Mining LTD", "date-changed": "20051222"}}
Unassociated Document
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C.  20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of Report (Date of earliest event reported):  November 22, 2011
22nd Century Group, Inc.
(Exact Name of Registrant as Specified in Charter)
Nevada
000-54111
98-0468420
(State or Other Jurisdiction of Incorporation)
(Commission File Number)
(I.R.S. Employer
dentification No.)
9530 Main Street
Clarence, New York
(Address of Principal Executive Office)
14031
(Zip Code)
Registrant's telephone number, including area code:
(716) 270-1523
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 1.01
Entry into a Material Definitive Agreement.
On November 22, 2011, 22nd Century Limited, LLC (the "Company")
a wholly-owned subsidiary of 22nd Century Group, Inc.,
entered into a Letter Agreement (the "Letter Agreement") with North Carolina State University ("NCSU").  The Letter Agreement provides that NCSU agreed to extend terms for (i) payments due and (ii) a peformance milestone under a license agreement effective as of March 6, 2009 between the Company and NCSU (the "License Agreement").
In addition, the Company agreed to pay  all outstanding amounts owed to NCSU on the earlier of (i) the closing of a capital raise of at least $5 million or (ii) October 15, 2012.
A copy of the Letter Agreement is attached hereto as Exhibit 10.1 to this Current Report on Form 8-K and is incorporated herein by reference.
Item 9.01
Financial Statements and Exhibits
(d)
Exhibits
10.1
Letter Agreement between the Company and NCSU dated November 22, 2011
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
22nd Century Group, Inc.
Date: November 23, 2011
/s/ Joseph Pandolfino
Joseph Pandolfino
Chief Executive Officer