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<P STYLE="font: 10pt/0.05pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">CURRENT REPORT FOR ISSUERS SUBJECT TO
THE</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">1934 ACT REPORTING REQUIREMENTS</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>FORM 8-K</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">SECURITIES AND EXCHANGE COMMISSION</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">Washington, DC 20549</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">CURRENT REPORT</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">Pursuant to Section 13 or 15(d) of the
Securities Exchange Act</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">Date of Report&nbsp;&nbsp;(Date of Earliest
Event Reported): March 6, 2012</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Radient Pharmaceuticals Corporation</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">(Exact name of registrant as specified
in its charter)</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
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    <TD STYLE="width: 33%; padding-right: 0.8pt; line-height: 115%; text-align: center">Delaware</TD>
    <TD STYLE="width: 33%; padding-right: 0.8pt; line-height: 115%; text-align: center">001-16695</TD>
    <TD STYLE="width: 33%; padding-right: 0.8pt; line-height: 115%; text-align: center">33-0413161</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">(State&nbsp;or&nbsp;other</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">jurisdiction&nbsp;of</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">(Commission&nbsp;File&nbsp;Number)</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">(IRS&nbsp;Employer&nbsp;Identification&nbsp;No.)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">incorporation)</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">&nbsp;</TD></TR>
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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">2492 Walnut Avenue, Suite 100, Tustin,
California, 92780-7039</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">(Address of principal executive offices
(zip code))</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">714-505-4461</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">(Registrant&rsquo;s telephone number,
including area code)</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; text-align: center">Check the appropriate box below if the
Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions
(see General Instruction A.2 below):</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

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    <TD STYLE="width: 1%; line-height: 115%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 3%; padding-right: 0.8pt; line-height: 115%"><FONT STYLE="font-family: Wingdings 2">&#163;</FONT></TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt; line-height: 115%; text-align: justify">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1%; line-height: 115%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 3%; padding-right: 0.8pt; line-height: 115%"><FONT STYLE="font-family: Wingdings 2">&#163;</FONT></TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt; line-height: 115%; text-align: justify">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a - 12)</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1%; line-height: 115%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 3%; padding-right: 0.8pt; line-height: 115%"><FONT STYLE="font-family: Wingdings 2">&#163;</FONT></TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt; line-height: 115%; text-align: justify">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1%; line-height: 115%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 3%; padding-right: 0.8pt; line-height: 115%"><FONT STYLE="font-family: Wingdings 2">&#163;</FONT></TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt; line-height: 115%; text-align: justify">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13d-4(c))</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center"></P>

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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 2.9pt 0 0 2.9pt"><B>Item 7.01 - Regulation FD</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 2.9pt 0 0 2.9pt"><B>Item 8.01- Other Events</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 5.8pt 0 0 5.8pt; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">As disclosed on the Current Report
on Form 8-K that we filed on February 23, 2012, we are actively seeking financing to improve our working capital shortage.
Also as disclosed in that 8-K, we received a term sheet with a potential investor that contemplates the issuance of an 18
month $3,315,000 convertible note that provides for an initial $250,000 advance and, subject to our satisfaction of certain
funding conditions, entitles us to receive additional advances of up to $2,750,000 over a period of approximately 11 months.
Since the filing of such 8-K, on March 5, 2012, we received a Securities Purchase Agreement to receive a $53,000 bridge loan.
This loan will enable us to pay overdue rent, utilities and make payments to our independent auditors so we can timely
file our Annual Report on Form 10-K for the year ending December 31, 2011, which is due on March 30, 2012.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">Pursuant to the Securities Purchase
Agreement, we shall issue an 8% Convertible Promissory Note to the lender. The Note matures on December 7, 2012 and is convertible
into shares of our common stock at a price equal to 58% multiplied by the average of the lowest three trading prices for our common
stock during the 10 trading days prior to the conversion date, subject to adjustment. The conversion price is subject to adjustment
following certain events, including mergers, reorganizations and the issuance of securities at a price lower than the then current
conversion price, in which case the conversion price shall be reduced to such lower price. We maintain the right to prepay the
note, at different percentages based upon the timing of prepayment; for example, if we prepay the note within 60 days of the issuance
date, we shall pay the note back at the rate of 130% of the outstanding balance, including accrued interest. Upon an event of default,
the note shall be immediately due and payable. An event of default caused by our failure to effect a conversion upon a conversion
notice shall cause us to pay double the amount due on the Note.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">Incurring additional indebtedness,
such as the Note constitutes an event of default under the notes we issued in November 2011 and therefore a default under the
notes issued to the investors of the Registered Direct Offering we completed in 2009 if we do not first obtain their consent.
Therefore, we shall seek to obtain consent for the Note from each such note holder after filing this 8-K and are filing this
8-K so that the consent does not constitute or include any material non-public information. If we obtain the necessary
consent and upon receipt of the loan, we shall file an amendment to this 8-K and attach the form of Securities Purchase
Agreement and Note as an exhibit thereto.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">This Current Report on Form 8-K is neither
an offer to sell nor the solicitation of an offer to buy our securities or any other securities and shall not constitute an offer
to sell or solicitation of offers to buy any securities.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify"></P>

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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">Pursuant to the requirements of the
Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-right: 1.8pt; line-height: 115%; font-weight: bold; text-align: left">RADIENT PHARMACEUTICALS CORPORATION</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; padding-right: 0.8pt; line-height: 115%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 35%; padding-right: 0.8pt; line-height: 115%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 61%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: justify">By:</TD>
    <TD STYLE="border-bottom: black 1pt solid; padding-right: 0.8pt; line-height: 115%; text-align: justify">&nbsp; /s/ Douglas MacLellan</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-right: 1.8pt; line-height: 115%; text-align: justify">Name:&nbsp;&nbsp;Douglas MacLellan</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-right: 1.8pt; line-height: 115%; text-align: justify">Title:&nbsp;&nbsp;&nbsp; Chief Executive Officer</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-right: 1.8pt; line-height: 115%; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Dated: March 6, 2012</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 10pt 0 0"></P>

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{"company-data": {"conformed-name": "RADIENT PHARMACEUTICALS Corp", "cik": "0000838879", "assigned-sic": "2834", "irs-number": "330413161", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-16695", "film-number": "12672001"}, "business-address": {"street1": "2492 WALNUT AVENUE", "street2": "STE 100", "city": "TUSTIN", "state": "CA", "zip": "92780", "phone": "7145054460"}, "mail-address": {"street1": "2492 WALNUT AVENUE", "street2": "STE 100", "city": "TUSTIN", "state": "CA", "zip": "92780"}, "former-company": [{"former-conformed-name": "AMDL INC", "date-changed": "19920703"}, {"former-conformed-name": "CALIFORNIA VENTURES INC", "date-changed": "19890905"}]}
CURRENT REPORT FOR ISSUERS SUBJECT TO
THE
1934 ACT REPORTING REQUIREMENTS
FORM 8-K
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act
Date of Report  (Date of Earliest
Event Reported): March 6, 2012
Radient Pharmaceuticals Corporation
(Exact name of registrant as specified
in its charter)
Delaware
001-16695
33-0413161
(State or other
jurisdiction of
(Commission File Number)
(IRS Employer Identification No.)
incorporation)
2492 Walnut Avenue, Suite 100, Tustin,
California, 92780-7039
(Address of principal executive offices
(zip code))
714-505-4461
(Registrant's telephone number,
including area code)
Check the appropriate box below if the
Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions
(see General Instruction A.2 below):
£
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
£
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a - 12)
£
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
£
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13d-4(c))
Item 7.01 - Regulation FD
Item 8.01- Other Events
As disclosed on the Current Report
on Form 8-K that we filed on February 23, 2012, we are actively seeking financing to improve our working capital shortage.
Also as disclosed in that 8-K, we received a term sheet with a potential investor that contemplates the issuance of an 18
month $3,315,000 convertible note that provides for an initial $250,000 advance and, subject to our satisfaction of certain
funding conditions, entitles us to receive additional advances of up to $2,750,000 over a period of approximately 11 months.
Since the filing of such 8-K, on March 5, 2012, we received a Securities Purchase Agreement to receive a $53,000 bridge loan.
This loan will enable us to pay overdue rent, utilities and make payments to our independent auditors so we can timely
file our Annual Report on Form 10-K for the year ending December 31, 2011, which is due on March 30, 2012.
Pursuant to the Securities Purchase
Agreement, we shall issue an 8% Convertible Promissory Note to the lender. The Note matures on December 7, 2012 and is convertible
into shares of our common stock at a price equal to 58% multiplied by the average of the lowest three trading prices for our common
stock during the 10 trading days prior to the conversion date, subject to adjustment. The conversion price is subject to adjustment
following certain events, including mergers, reorganizations and the issuance of securities at a price lower than the then current
conversion price, in which case the conversion price shall be reduced to such lower price. We maintain the right to prepay the
note, at different percentages based upon the timing of prepayment; for example, if we prepay the note within 60 days of the issuance
date, we shall pay the note back at the rate of 130% of the outstanding balance, including accrued interest. Upon an event of default,
the note shall be immediately due and payable. An event of default caused by our failure to effect a conversion upon a conversion
notice shall cause us to pay double the amount due on the Note.
Incurring additional indebtedness,
such as the Note constitutes an event of default under the notes we issued in November 2011 and therefore a default under the
notes issued to the investors of the Registered Direct Offering we completed in 2009 if we do not first obtain their consent.
Therefore, we shall seek to obtain consent for the Note from each such note holder after filing this 8-K and are filing this
8-K so that the consent does not constitute or include any material non-public information. If we obtain the necessary
consent and upon receipt of the loan, we shall file an amendment to this 8-K and attach the form of Securities Purchase
Agreement and Note as an exhibit thereto.
This Current Report on Form 8-K is neither
an offer to sell nor the solicitation of an offer to buy our securities or any other securities and shall not constitute an offer
to sell or solicitation of offers to buy any securities.
SIGNATURES
Pursuant to the requirements of the
Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.
RADIENT PHARMACEUTICALS CORPORATION
By:
/s/ Douglas MacLellan
Name:  Douglas MacLellan
Title:    Chief Executive Officer
Dated: March 6, 2012