content: SECURITIES AND EXCHANGE COMMISSION
                               Washington, D.C. 20549
  
                                      FORM 8-K
  
                                   CURRENT REPORT
  
     Pursuant to Section 13 or 15(d) of the Securities and Exchange Act of 1934
  
                          Date of Report: December 13, 2000
                          (Date of earliest event reported)
  
                             XECHEM INTERNATIONAL, INC.
               (Exact name of registrant as specified in the charter)
  
             Delaware                     0-23788                   32-3284403
  (State or other jurisdiction     (Commission File No.)          (IRS Employer
         of incorporation)                                     Identification No.)
  
                      100 Jersey Avenue, Building B, Suite 310
                        New Brunswick, New Jersey 08901-3279
                      (Address of Principal Executive Offices)
  
                                   (732) 247-3300
                 Registrant's telephone number including area code)
  
            (Former name or former address, if changed since last report)
  
  <PAGE>
  
  ITEM 4. CHANGES IN REGISTRANT'S CERTIFYING ACCOUNTANT
  
       On  December  6,  2000,  Xechem  International,   Inc.  (the  "Registrant")
  announced that it had decided to terminate its relationship with its independent
  accountants,  Wiss and Company, LLP, and had engaged Grant Thornton,  LLP as the
  Registrant's  independent  accountants  to audit and report on the  Registrant's
  annual  financial  statements  for the year ending  December 31, 2000. The Audit
  Committee of the Registrant approved this decision. Over the last two years, the
  report of Wiss & Company, LLP contained a statement that there were doubts about
  the  ability of the  Registrant  to  continue  as a going  concern.  The Company
  disagreed  with Wiss & Company's  requirement  to use quoted market value (where
  there was no  objective  evidence  of fair  value) in  valuing  stock  issued to
  employees.  Further,  it disagreed with Wiss & Company to value shares issued to
  consultants  at fair  value.  The  Company  had  originally  used par  value but
  ultimately accepted Wiss' position. These matters were discussed on July 7, 2000
  with the Audit  Committee.  Except for these  valuations,  at no time during the
  Registrant's  two most recent years,  and any  subsequent  interim period before
  retaining Grant Thornton,  LLP, did Registrant have any disagreements  with Wiss
  and Company,  LLP  concerning  accounting  principles  or  practices,  financial
  statement  disclosure  or  auditing  scope or  procedure.  At no time during the
  Registrant's  two most recent fiscal years,  and any  subsequent  interim period
  prior  to  engaging  Grant  Thornton,  LLP,  did the  Registrant  consult  Grant
  Thornton, LLP regarding: (i) either: the application of accounting principles to
  a specified  transaction,  either  completed or  proposed,  or the type of audit
  opinion that might be rendered on the Registrant's financial statements; or (ii)
  any matter that was either the subject of a disagreement as defined in paragraph
  304(a)(1)(iv)  of Regulation  S-K and the related  instructions  or a reportable
  event described in paragraph  304(a)(1)(v).  At no time during the  Registrant's
  two most recent  fiscal years and the interim  period  through  December 6, 2000
  were there any  reportable  events with Wiss and  Company,  LLP, as described in
  Item 304(a)(1)(v) of Regulation S-K.
  
  ITEM 7. FINANCIAL STATEMENTS AND EXHIBITS
  
       (b)(i) Letter from Wiss and Company, LLP
  
  <PAGE>
  
                                     SIGNATURES
  
       Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
  Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
  undersigned hereunto duly authorized.
  
                                          XECHEM INTERNATIONAL, INC.
  
  Dated:  December 13, 2000               By: /s/ Dr. Ramesh C. Pandey
                                              -----------------------------
                                          Its: President and Chairman of the
                                               Board of Directors
  
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text: SECURITIES AND EXCHANGE COMMISSION
                               Washington, D.C. 20549
  
                                      FORM 8-K
  
                                   CURRENT REPORT
  
     Pursuant to Section 13 or 15(d) of the Securities and Exchange Act of 1934
  
                          Date of Report: December 13, 2000
                          (Date of earliest event reported)
  
                             XECHEM INTERNATIONAL, INC.
               (Exact name of registrant as specified in the charter)
  
             Delaware                     0-23788                   32-3284403
  (State or other jurisdiction     (Commission File No.)          (IRS Employer
         of incorporation)                                     Identification No.)
  
                      100 Jersey Avenue, Building B, Suite 310
                        New Brunswick, New Jersey 08901-3279
                      (Address of Principal Executive Offices)
  
                                   (732) 247-3300
                 Registrant's telephone number including area code)
  
            (Former name or former address, if changed since last report)
  ITEM 4. CHANGES IN REGISTRANT'S CERTIFYING ACCOUNTANT
  
       On  December  6,  2000,  Xechem  International,   Inc.  (the  "Registrant")
  announced that it had decided to terminate its relationship with its independent
  accountants,  Wiss and Company, LLP, and had engaged Grant Thornton,  LLP as the
  Registrant's  independent  accountants  to audit and report on the  Registrant's
  annual  financial  statements  for the year ending  December 31, 2000. The Audit
  Committee of the Registrant approved this decision. Over the last two years, the
  report of Wiss & Company, LLP contained a statement that there were doubts about
  the  ability of the  Registrant  to  continue  as a going  concern.  The Company
  disagreed  with Wiss & Company's  requirement  to use quoted market value (where
  there was no  objective  evidence  of fair  value) in  valuing  stock  issued to
  employees.  Further,  it disagreed with Wiss & Company to value shares issued to
  consultants  at fair  value.  The  Company  had  originally  used par  value but
  ultimately accepted Wiss' position. These matters were discussed on July 7, 2000
  with the Audit  Committee.  Except for these  valuations,  at no time during the
  Registrant's  two most recent years,  and any  subsequent  interim period before
  retaining Grant Thornton,  LLP, did Registrant have any disagreements  with Wiss
  and Company,  LLP  concerning  accounting  principles  or  practices,  financial
  statement  disclosure  or  auditing  scope or  procedure.  At no time during the
  Registrant's  two most recent fiscal years,  and any  subsequent  interim period
  prior  to  engaging  Grant  Thornton,  LLP,  did the  Registrant  consult  Grant
  Thornton, LLP regarding: (i) either: the application of accounting principles to
  a specified  transaction,  either  completed or  proposed,  or the type of audit
  opinion that might be rendered on the Registrant's financial statements; or (ii)
  any matter that was either the subject of a disagreement as defined in paragraph
  304(a)(1)(iv)  of Regulation  S-K and the related  instructions  or a reportable
  event described in paragraph  304(a)(1)(v).  At no time during the  Registrant's
  two most recent  fiscal years and the interim  period  through  December 6, 2000
  were there any  reportable  events with Wiss and  Company,  LLP, as described in
  Item 304(a)(1)(v) of Regulation S-K.
  
  ITEM 7. FINANCIAL STATEMENTS AND EXHIBITS
  
       (b)(i) Letter from Wiss and Company, LLP
  SIGNATURES
  
       Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
  Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
  undersigned hereunto duly authorized.
  
                                          XECHEM INTERNATIONAL, INC.
  
  Dated:  December 13, 2000               By: /s/ Dr. Ramesh C. Pandey
                                              -----------------------------
                                          Its: President and Chairman of the
                                               Board of Directors
  
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