content: <PAGE>
  
                       SECURITIES  AND  EXCHANGE  COMMISSION
  
                              Washington, D.C. 20549
  
                                   ____________
  
  
  
  
                                     FORM 8-K
  
                                  CURRENT REPORT
  
  
  
  
                      Pursuant to Section 13 or 15(d) of the
                          Securities Exchange Act of 1934
  
                        Date of Report:  December 19, 2000
                         (Date of earliest event reported)
  
                                   CARDIMA, INC.
              (Exact name of registrant as specified in its charter)
  
           Delaware                    0-22419                     94-3177883
  (State or other jurisdiction      (Commission               (IRS Employer
         of incorporation)           File Number)              Identification No.)
  
                  47266 Benicia Street, Fremont, California 94538
             (Address of principal executive offices)       (Zip Code)
  
        Registrant's telephone number, including area code:  (510) 354-0300
  <PAGE>
  
  ITEM 2.    ACQUISITION OR DISPOSITION OF ASSETS
  
       Cardima, Inc. sold a portion of its patent portfolio and related
  intellectual property pertaining to intravascular sensing and signal detection
  and certain guiding catheters to Medtronic, Inc. for $8,000,000 in cash,
  $4,000,000 of which was paid on execution of the agreement on December 19, 2000.
  The balance will be paid on completion of the transfer of the property, which is
  expected to take less than 45 days. Cardima received back a co-exclusive,
  perpetual, fully paid license for the right to use these patents for its core
  business interest, mapping and ablation.  The terms of the transaction were
  based on arms-length negotiations between the parties and were not based on an
  appraisal or any other formal method of valuation of the property.
  
  ITEM 7.    FINANCIAL STATEMENTS AND EXHIBITS
  
       Cardima, Inc. is not filing the required financial statements and pro forma
  information at this time. Cardima, Inc. will file such financial statements as
  an amendment to this Form 8-K no later than sixty (60) days after the date of
  filing of this initial Form 8-K pursuant to Item 7 of Form 8-K.
  
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  <PAGE>
  
                                     SIGNATURE
  
       Pursuant to the requirements of the Securities Exchange Act of 1934, the
  registrant has duly caused this report to be signed on its behalf by the
  undersigned hereunto duly authorized.
  
       Dated:  December 22, 2000
  
                               CARDIMA, INC.
  
                                By  /s/  Ronald E. Bourquin
                                    -----------------------
                                    Ronald E. Bourquin
                                    Vice President and
                                    Chief Financial Officer
  
  
  
  
  
  
                                         3
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text: SECURITIES  AND  EXCHANGE  COMMISSION
  
                              Washington, D.C. 20549
  
                                   ____________
  
                                     FORM 8-K
  
                                  CURRENT REPORT
  
                      Pursuant to Section 13 or 15(d) of the
                          Securities Exchange Act of 1934
  
                        Date of Report:  December 19, 2000
                         (Date of earliest event reported)
  
                                   CARDIMA, INC.
              (Exact name of registrant as specified in its charter)
  
           Delaware                    0-22419                     94-3177883
  (State or other jurisdiction      (Commission               (IRS Employer
         of incorporation)           File Number)              Identification No.)
  
                  47266 Benicia Street, Fremont, California 94538
             (Address of principal executive offices)       (Zip Code)
  
        Registrant's telephone number, including area code:  (510) 354-0300
  ITEM 2.    ACQUISITION OR DISPOSITION OF ASSETS
  
       Cardima, Inc. sold a portion of its patent portfolio and related
  intellectual property pertaining to intravascular sensing and signal detection
  and certain guiding catheters to Medtronic, Inc. for $8,000,000 in cash,
  $4,000,000 of which was paid on execution of the agreement on December 19, 2000.
  The balance will be paid on completion of the transfer of the property, which is
  expected to take less than 45 days. Cardima received back a co-exclusive,
  perpetual, fully paid license for the right to use these patents for its core
  business interest, mapping and ablation.  The terms of the transaction were
  based on arms-length negotiations between the parties and were not based on an
  appraisal or any other formal method of valuation of the property.
  
  ITEM 7.    FINANCIAL STATEMENTS AND EXHIBITS
  
       Cardima, Inc. is not filing the required financial statements and pro forma
  information at this time. Cardima, Inc. will file such financial statements as
  an amendment to this Form 8-K no later than sixty (60) days after the date of
  filing of this initial Form 8-K pursuant to Item 7 of Form 8-K.
  
                                         2
  SIGNATURE
  
       Pursuant to the requirements of the Securities Exchange Act of 1934, the
  registrant has duly caused this report to be signed on its behalf by the
  undersigned hereunto duly authorized.
  
       Dated:  December 22, 2000
  
                               CARDIMA, INC.
  
                                By  /s/  Ronald E. Bourquin
                                    -----------------------
                                    Ronald E. Bourquin
                                    Vice President and
                                    Chief Financial Officer
  
                                         3