content: <PAGE>
  
  ================================================================================
  
                                   UNITED STATES
                        SECURITIES AND EXCHANGE COMMISSION
                              Washington, D.C. 20549
  
                           -----------------------------
                                     FORM 8-K
  
                 Current Report Pursuant to Section 13 or 15(d) of
                        the Securities Exchange Act of 1934
  
       Date of Report (Date of Earliest Event Reported):  November 30, 2000
  
  
                           CENTAUR PHARMACEUTICALS, INC.
              (Exact Name of Registrant as Specified in its Charter)
  
                                     Delaware
                  (State or Other Jurisdiction of Incorporation)
  
  
               000-24831                                   77-0304313
        (Commission File Number)                (IRS Employer Identification No.)
  
  
                                484 Oakmead Parkway
                            Sunnyvale, California 94085
                (Address of principal executive offices) (zip code)
  
                                  (408) 822-1600
               (Registrant's Telephone Number, Including Area Code)
  
                                  Not Applicable
           (Former Name or Former Address, if Changed Since Last Report)
  
  ================================================================================
  
  ITEM 5.  OTHER EVENTS
  
        Effective November 30, 2000, the Certificate of Incorporation of Centaur
  was amended to permit stockholders to act by written consent beyond December 31,
  2000. This amendment was approved at a meeting of the Board of Directors and by
  the written consent of stockholders of Centaur. As a result of the amendment,
  stockholders will continue to be able to act by written consent until such time
  as Centaur closes an underwritten offering, which results in Centaur shares
  being traded on a significant public market specified in the amendment.
  
        Effective November 30, 2000 pursuant to Board approval, the Bylaws of
  Centaur were also amended to permit stockholders to act by written consent
  beyond December 31, 2000.
  <PAGE>
  
  ITEM 7. FINANCIAL STATEMENTS AND EXHIBITS
  
  (c)  Exhibits
  
       Exhibit
       Number     Exhibit Title
       ------     -------------
       3.01       Certificate of Amendment of Registrant's Restated Certificate
                  of Incorporation
       3.02       Amendment of Registrant's Bylaws
  
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  Registrant has duly caused this report to be signed on its behalf by the
  undersigned thereunto duly authorized.
  
                                           CENTAUR PHARMACEUTICALS, INC.
                                           (Registrant)
  
  
  December 8, 2000.                        By:  /s/ Lucy O. Day
                                              -----------------------------------
                                                         Lucy O. Day
                                                Chief Financial Officer, Treasurer
                                                         and Secretary
  <PAGE>
  
                                   EXHBIT INDEX
                                   ------------
  
       Exhibit
       Number      Exhibit Title
       ------      -------------
       3.01        Certificate of Amendment of Registrant's Restated Certificate
                   of Incorporation
       3.02        Amendment of Registrant's Bylaws
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text: ================================================================================
  
                                   UNITED STATES
                        SECURITIES AND EXCHANGE COMMISSION
                              Washington, D.C. 20549
  
                           -----------------------------
                                     FORM 8-K
  
                 Current Report Pursuant to Section 13 or 15(d) of
                        the Securities Exchange Act of 1934
  
       Date of Report (Date of Earliest Event Reported):  November 30, 2000
  
                           CENTAUR PHARMACEUTICALS, INC.
              (Exact Name of Registrant as Specified in its Charter)
  
                                     Delaware
                  (State or Other Jurisdiction of Incorporation)
  
               000-24831                                   77-0304313
        (Commission File Number)                (IRS Employer Identification No.)
  
                                484 Oakmead Parkway
                            Sunnyvale, California 94085
                (Address of principal executive offices) (zip code)
  
                                  (408) 822-1600
               (Registrant's Telephone Number, Including Area Code)
  
                                  Not Applicable
           (Former Name or Former Address, if Changed Since Last Report)
  
  ================================================================================
  
  ITEM 5.  OTHER EVENTS
  
        Effective November 30, 2000, the Certificate of Incorporation of Centaur
  was amended to permit stockholders to act by written consent beyond December 31,
  2000. This amendment was approved at a meeting of the Board of Directors and by
  the written consent of stockholders of Centaur. As a result of the amendment,
  stockholders will continue to be able to act by written consent until such time
  as Centaur closes an underwritten offering, which results in Centaur shares
  being traded on a significant public market specified in the amendment.
  
        Effective November 30, 2000 pursuant to Board approval, the Bylaws of
  Centaur were also amended to permit stockholders to act by written consent
  beyond December 31, 2000.
  ITEM 7. FINANCIAL STATEMENTS AND EXHIBITS
  
  (c)  Exhibits
  
       Exhibit
       Number     Exhibit Title
       ------     -------------
       3.01       Certificate of Amendment of Registrant's Restated Certificate
                  of Incorporation
       3.02       Amendment of Registrant's Bylaws
  
  Pursuant to the requirements of the Securities Exchange Act of 1934, the
  Registrant has duly caused this report to be signed on its behalf by the
  undersigned thereunto duly authorized.
  
                                           CENTAUR PHARMACEUTICALS, INC.
                                           (Registrant)
  
  December 8, 2000.                        By:  /s/ Lucy O. Day
                                              -----------------------------------
                                                         Lucy O. Day
                                                Chief Financial Officer, Treasurer
                                                         and Secretary
  EXHBIT INDEX
                                   ------------
  
       Exhibit
       Number      Exhibit Title
       ------      -------------
       3.01        Certificate of Amendment of Registrant's Restated Certificate
                   of Incorporation
       3.02        Amendment of Registrant's Bylaws