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<TITLE>Form 8-K</TITLE>
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 <P STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #000000">&nbsp;</P>
<P STYLE="line-height:3.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&nbsp;</P> <P STYLE="margin-top:4pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman" ALIGN="center"><B>UNITED STATES </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman" ALIGN="center"><B>SECURITIES AND EXCHANGE COMMISSION </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman" ALIGN="center"><B>WASHINGTON, D.C. 20549 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center>
<P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman" ALIGN="center"><B>FORM <FONT
STYLE="white-space:nowrap">8-K</FONT> </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center>
<P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman" ALIGN="center"><B>CURRENT
REPORT </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman" ALIGN="center"><B>Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934 </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman" ALIGN="center"><B>Date of Report (Date of earliest event reported):&nbsp;January 8, 2019 </B></P>
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<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:24pt; font-family:Times New Roman" ALIGN="center"><B>SHIRE&nbsp;PLC </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>(Exact
name of registrant as specified in its charter) </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center>
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<TD VALIGN="top" ALIGN="center"><B>Jersey, Channel Islands</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" ALIGN="center"><B><FONT STYLE="white-space:nowrap">0-29630</FONT></B></TD>
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<TD VALIGN="top" ALIGN="center"><B><FONT STYLE="white-space:nowrap">98-0601486</FONT></B></TD></TR>
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<TD VALIGN="top" ALIGN="center"><B>(State or other jurisdiction<BR>of incorporation)</B></TD>
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<TD VALIGN="top" ALIGN="center"><B>(Commission<BR>File Number)</B></TD>
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<TD VALIGN="top" ALIGN="center"><B>(IRS Employer<BR>Identification No.)</B></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Block 2 </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Miesian Plaza </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B><FONT
STYLE="white-space:nowrap">50-58</FONT> Baggot Street Lower </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Dublin 2 </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Republic of Ireland </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>(Address of principal executive offices) </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Registrant&#146;s telephone number, including area code:&nbsp;+353 1&nbsp;429 7700 </B></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>(Former name or former address, if changed since last report) </B></P>
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<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Check the appropriate box below if the <FONT STYLE="white-space:nowrap">Form&nbsp;8-K</FONT> filing is intended to simultaneously satisfy the filing
obligation of the registrant under any of the following provisions: </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">Written communications pursuant to Rule&nbsp;425 under the Securities Act (17 CFR
230.425)</P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">Soliciting material pursuant to <FONT STYLE="white-space:nowrap">Rule&nbsp;14a-12</FONT> under the Exchange Act
(17 CFR <FONT STYLE="white-space:nowrap">240.14a-12)</FONT></P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left"><FONT STYLE="white-space:nowrap">Pre-commencement</FONT> communications pursuant to <FONT
STYLE="white-space:nowrap">Rule&nbsp;14d-2(b)</FONT> under the Exchange Act <FONT STYLE="white-space:nowrap">(17&nbsp;CFR&nbsp;240.14d-2(b))</FONT></P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left"><FONT STYLE="white-space:nowrap">Pre-commencement</FONT> communications pursuant to <FONT
STYLE="white-space:nowrap">Rule&nbsp;13e-4(c)</FONT> under the Exchange Act <FONT STYLE="white-space:nowrap">(17&nbsp;CFR&nbsp;240.13e-4(c))</FONT> </P></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR &#167;230.405) or
Rule <FONT STYLE="white-space:nowrap">12b-2</FONT> of the Securities Exchange Act of 1934 (17 CFR <FONT STYLE="white-space:nowrap">&#167;240.12b-2).</FONT> </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Emerging growth company&nbsp;&nbsp;&#9744; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">If an emerging
growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section&nbsp;13(a) of the Exchange
Act.&nbsp;&nbsp;&#9744; </P> <P STYLE="font-size:10pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #000000">&nbsp;</P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B><U>INTRODUCTORY NOTE </U></B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">On May&nbsp;8, 2018, Shire plc (&#147;<B>Shire</B>&#148;) and Takeda Pharmaceutical Company Limited (&#147;<B>Takeda</B>&#148;) announced that
they had reached agreement on the terms of a recommended cash and share offer to be made by Takeda for the entire issued and to be issued share capital of Shire (the &#147;<B>Acquisition</B>&#148;). The Acquisition is to be effected by means of a
scheme of arrangement under Article 125 of the Companies (Jersey) Law 1991 (as amended) (the &#147;<B>Scheme</B>&#148;). The Scheme took effect, and the Acquisition was completed, on January&nbsp;8, 2019 (the &#147;<B>Effective Date</B>&#148;).
Accordingly, as a result of the Acquisition, Shire became a wholly-owned subsidiary of Takeda.</P> <P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="9%" VALIGN="top" ALIGN="left"><B>Item&nbsp;1.02</B></TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left"><B>Termination of a Material Definitive Agreement. </B></P></TD></TR></TABLE>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">On May&nbsp;8, 2018, Shire and Takeda entered into the <FONT STYLE="white-space:nowrap">Co-Operation</FONT> Agreement in connection with the
proposed Acquisition. Under the <FONT STYLE="white-space:nowrap">Co-Operation</FONT> Agreement, Shire agreed to provide Takeda with such information and assistance as Takeda may reasonably require for the purposes of obtaining all regulatory
clearances and making any submission, filing or notification to any regulatory authority, and Takeda gave certain undertakings to implement the Acquisition. Pursuant to Section&nbsp;14.1(G) of the <FONT STYLE="white-space:nowrap">Co-Operation</FONT>
Agreement, the <FONT STYLE="white-space:nowrap">Co-Operation</FONT> Agreement was terminated with immediate effect on the Effective Date. In connection with the termination of the <FONT STYLE="white-space:nowrap">Co-Operation</FONT> Agreement, all
rights and obligations of Shire and Takeda under the <FONT STYLE="white-space:nowrap">Co-Operation</FONT> Agreement ceased. </P> <P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="9%" VALIGN="top" ALIGN="left"><B>Item&nbsp;2.01</B></TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left"><B>Completion of Acquisition or Disposition of Assets. </B></P></TD></TR></TABLE>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Acquisition was completed on January&nbsp;8, 2019.&nbsp;Accordingly, as a result of the Acquisition and as of the Effective Date, Shire
became a wholly-owned subsidiary of Takeda.&nbsp;Under the terms of the Acquisition, each Shire Shareholder is entitled to receive for each Shire Share (i) $30.33 in cash and (ii)&nbsp;either 0.839 New Takeda Shares or, subject to a valid election
being made, 1.678 New Takeda ADSs (the &#147;<B>Consideration</B>&#148;). Shire ADS holders were not entitled to make elections in respect of their Shire ADSs. Instead, Citibank, N.A., as depositary for Shire&#146;s ADR program, will be entitled to
receive $30.33 in cash and has elected to receive 1.678 New Takeda ADSs in respect of each Shire Share underlying a Shire ADS. As each Shire ADS represents three Shire Shares, Shire ADS holders will be entitled to receive $90.99 in cash and 5.034
New Takeda ADS for each Shire ADS held at the ADS Effective Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The foregoing description of the Scheme and the Acquisition is not
complete and is qualified in its entirety by reference to the <FONT STYLE="white-space:nowrap">Co-Operation</FONT> Agreement filed as Exhibit 2.1 to Shire&#146;s Form <FONT STYLE="white-space:nowrap">8-K</FONT> filed on May&nbsp;9, 2018, which is
incorporated herein in its entirety by reference. </P> <P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="9%" VALIGN="top" ALIGN="left"><B>Item&nbsp;3.01</B></TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left"><B>Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing.
</B></P></TD></TR></TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">On January&nbsp;8, 2019, Shire notified NASDAQ that the Acquisition had been completed. Shire also requested that
NASDAQ file with the Securities and Exchange Commission (the &#147;<B>SEC</B>&#148;) a notification of removal from listing and registration on Form 25 to effect the delisting of the Shire ADSs from NASDAQ and the deregistration of Shire ADSs and
Shire Shares under Section&nbsp;12(b) of the Securities Exchange Act of 1934, as amended (the &#147;<B>Exchange</B> <B>Act</B>&#148;). As a result, Shire ADSs will no longer be listed on NASDAQ. In addition, Shire intends to file a certification on
Form 15 with the SEC requesting the termination of registration of Shire ADSs under Section&nbsp;12(g) of the Exchange Act and the suspension of Shire&#146;s reporting obligations under Sections 13 and 15(d) of the Exchange Act with respect to Shire
ADSs. </P> <P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="9%" VALIGN="top" ALIGN="left"><B>Item&nbsp;3.03</B></TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left"><B>Material Modification to Rights of Security Holders. </B></P></TD></TR></TABLE>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The information in Item 2.01 and 3.01 is incorporated by reference herein. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">On the Effective Date, Shire&#146;s shareholders ceased to have any rights as shareholders of Shire, other than their right to receive the
Consideration. </P>
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<TD WIDTH="9%" VALIGN="top" ALIGN="left"><B>Item&nbsp;5.01</B></TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left"><B>Changes in Control of Registrant. </B></P></TD></TR></TABLE>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The information in Item 2.01 and 3.01, as well as the information in &#147;Item 5. Operating and Financial Review and Prospects&#151;B.
Liquidity and Capital Resources&#151;Financing Arrangements for the Shire Acquisition&#148; of Takeda&#146;s Form <FONT STYLE="white-space:nowrap">20-F</FONT> filed on December&nbsp;17, 2018, is incorporated by reference herein. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">On the Effective Date, a change of control of Shire occurred, and Shire is now a wholly-owned subsidiary of Takeda. </P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>Item&nbsp;5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain
Officers. </B></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">On January&nbsp;8, 2019, in connection with the Acquisition, Susan Kilsby, Flemming Ornskov, Thomas Dittrich, Olivier
Bohuon, Ian Clark, Gail Fosler, Steven Gillis, David Ginsburg, Sara Mathew and Albert Stroucken resigned and ceased to be members of the Board of Directors of Shire (including any committees thereof) and Bill Mordan resigned and ceased to be company
secretary of Shire.&nbsp;These resignations were not a result of any disagreements between Shire and its directors on any matter relating to Shire&#146;s operations, policies or practices. On the Effective Date, the following persons were elected
members of the Board of Directors of Shire: Susan O&#146;Reilly, Amitabh Singh, Anthony Denis Ahern, Nigel Coffey, Paul Keogh, Anthony Grannell, John Ryan and James Dinniss. On the Effective Date, Susan O&#146;Reilly was appointed as secretary of
Shire with immediate effect and Mourant Secretaries (Jersey) Limited was appointed as assistant secretary of Shire with immediate effect. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Mssrs. Bohuon, Clark and Gillis were previously elected to the Board of Directors of Takeda on December&nbsp;5, 2018, and such appointments
took effect as of the Effective Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Pursuant to separation agreements entered into with each of Dr.&nbsp;Ornskov and Mr.&nbsp;Dittrich,
Dr.&nbsp;Ornskov and Mr.&nbsp;Dittrich are&nbsp;each eligible to receive a contract termination payment in an amount equal to the sum of two times each executive&#146;s respective base salary payable for the 2018 financial year and two times each
executive&#146;s respective target bonus for the 2018 financial year, reduced by the amount paid to each executive under his executive employment agreement, on June&nbsp;30, 2019. Shire will also cover the reasonable costs of Dr.&nbsp;Ornskov&#146;s
health and dental benefits for twelve months from January&nbsp;8, 2019 and will cover the reasonable costs associated with his repatriation up to a maximum cost of $500,000 should he work in Switzerland as a result of visa considerations. </P>
<P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="9%" VALIGN="top" ALIGN="left"><B>Item&nbsp;5.03</B></TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left"><B>Amendments to Articles of Association or Bylaws; Change in Fiscal Year. </B></P></TD></TR></TABLE>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The information in Item 2.01 and 3.01 is incorporated by reference herein. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Following the Effectiveness of the Scheme, on January 8, 2019, the Articles of Association of Shire were amended and restated in their
entirety, a copy of which is filed as Exhibit 3.1 to this Form <FONT STYLE="white-space:nowrap">8-K</FONT> and is incorporated by reference herein. </P> <P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="9%" VALIGN="top" ALIGN="left"><B>Item&nbsp;9.01</B></TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left"><B>Financial Statements and Exhibits.</B></P></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="5%" VALIGN="top" ALIGN="left">(d)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">Exhibits </P></TD></TR></TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP ALIGN="center"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Times New Roman; " ALIGN="center"><B>Exhibit<BR>No.</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Times New Roman; "><B>Description</B></P></TD></TR>


<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" NOWRAP>&nbsp;&nbsp;3.1</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Articles of Association of Shire plc as amended and adopted by a special resolution on January 8, 2019.</TD></TR>
</TABLE>
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<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>EXHIBIT INDEX</B></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt" ALIGN="center">


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<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Times New Roman; "><B>Description</B></P></TD></TR>


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<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" NOWRAP>&nbsp;&nbsp;3.1</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><A HREF="d673508dex31.htm">Articles of Association of Shire plc as amended and adopted by a special resolution on January&nbsp;8, 2019.</A></TD></TR>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>SIGNATURES </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="5">SHIRE&nbsp;PLC</TD>
<TD VALIGN="bottom">&nbsp;</TD>
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<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Date: January&nbsp;8, 2019</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Susan O&#146;Reilly</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">&nbsp;&nbsp;&nbsp;&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
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<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Susan O&#146;Reilly</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Company Secretary</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD></TR>
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</BODY></HTML>
[{"type": "8-K", "sequence": "1", "filename": "d673508d8k.htm", "description": "FORM 8-K", "secsgml_size_bytes": 28790}]
{"company-data": {"conformed-name": "Shire plc", "cik": "0000936402", "assigned-sic": "2834", "irs-number": "000000000", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "001-37896", "film-number": "19515874"}, "business-address": {"street1": "BLOCK 2, MIESIAN PLAZA", "street2": "50-58 BAGGOT STREET LOWER", "city": "DUBLIN 2", "state": "L2", "zip": "D02 HW68", "phone": "353-1-609-6000"}, "mail-address": {"street1": "BLOCK 2, MIESIAN PLAZA", "street2": "50-58 BAGGOT STREET LOWER", "city": "DUBLIN 2", "state": "L2", "zip": "D02 HW68"}, "former-company": [{"former-conformed-name": "Shire Ltd.", "date-changed": "20080523"}, {"former-conformed-name": "Shire plc", "date-changed": "20051125"}, {"former-conformed-name": "SHIRE PHARMACEUTICALS GROUP PLC", "date-changed": "19980302"}]}
Form 8-K
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM
8-K
CURRENT
REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): January 8, 2019
SHIRE PLC
(Exact
name of registrant as specified in its charter)
Jersey, Channel Islands
0-29630
98-0601486
(State or other jurisdiction
of incorporation)
(Commission
File Number)
(IRS Employer
Identification No.)
Block 2
Miesian Plaza
50-58
Baggot Street Lower
Dublin 2
Republic of Ireland
(Address of principal executive offices)
Registrant's telephone number, including area code: +353 1 429 7700
(Former name or former address, if changed since last report)
Check the appropriate box below if the
Form 8-K
filing is intended to simultaneously satisfy the filing
obligation of the registrant under any of the following provisions:
☐
Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)
☐
Soliciting material pursuant to
Rule 14a-12
under the Exchange Act
(17 CFR
240.14a-12)
☐
Pre-commencement
communications pursuant to
Rule 14d-2(b)
under the Exchange Act
(17 CFR 240.14d-2(b))
☐
Pre-commencement
communications pursuant to
Rule 13e-4(c)
under the Exchange Act
(17 CFR 240.13e-4(c))
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or
Rule
12b-2
of the Securities Exchange Act of 1934 (17 CFR
§240.12b-2).
Emerging growth company  ☐
If an emerging
growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange
Act.  ☐
INTRODUCTORY NOTE
On May 8, 2018, Shire plc ("
Shire
") and Takeda Pharmaceutical Company Limited ("
Takeda
") announced that
they had reached agreement on the terms of a recommended cash and share offer to be made by Takeda for the entire issued and to be issued share capital of Shire (the "
Acquisition
"). The Acquisition is to be effected by means of a
scheme of arrangement under Article 125 of the Companies (Jersey) Law 1991 (as amended) (the "
Scheme
"). The Scheme took effect, and the Acquisition was completed, on January 8, 2019 (the "
Effective Date
").
Accordingly, as a result of the Acquisition, Shire became a wholly-owned subsidiary of Takeda.
Item 1.02
Termination of a Material Definitive Agreement.
On May 8, 2018, Shire and Takeda entered into the
Co-Operation
Agreement in connection with the
proposed Acquisition. Under the
Co-Operation
Agreement, Shire agreed to provide Takeda with such information and assistance as Takeda may reasonably require for the purposes of obtaining all regulatory
clearances and making any submission, filing or notification to any regulatory authority, and Takeda gave certain undertakings to implement the Acquisition. Pursuant to Section 14.1(G) of the
Co-Operation
Agreement, the
Co-Operation
Agreement was terminated with immediate effect on the Effective Date. In connection with the termination of the
Co-Operation
Agreement, all
rights and obligations of Shire and Takeda under the
Co-Operation
Agreement ceased.
Item 2.01
Completion of Acquisition or Disposition of Assets.
The Acquisition was completed on January 8, 2019. Accordingly, as a result of the Acquisition and as of the Effective Date, Shire
became a wholly-owned subsidiary of Takeda. Under the terms of the Acquisition, each Shire Shareholder is entitled to receive for each Shire Share (i) $30.33 in cash and (ii) either 0.839 New Takeda Shares or, subject to a valid election
being made, 1.678 New Takeda ADSs (the "
Consideration
"). Shire ADS holders were not entitled to make elections in respect of their Shire ADSs. Instead, Citibank, N.A., as depositary for Shire's ADR program, will be entitled to
receive $30.33 in cash and has elected to receive 1.678 New Takeda ADSs in respect of each Shire Share underlying a Shire ADS. As each Shire ADS represents three Shire Shares, Shire ADS holders will be entitled to receive $90.99 in cash and 5.034
New Takeda ADS for each Shire ADS held at the ADS Effective Date.
The foregoing description of the Scheme and the Acquisition is not
complete and is qualified in its entirety by reference to the
Co-Operation
Agreement filed as Exhibit 2.1 to Shire's Form
8-K
filed on May 9, 2018, which is
incorporated herein in its entirety by reference.
Item 3.01
Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing.
On January 8, 2019, Shire notified NASDAQ that the Acquisition had been completed. Shire also requested that
NASDAQ file with the Securities and Exchange Commission (the "
SEC
") a notification of removal from listing and registration on Form 25 to effect the delisting of the Shire ADSs from NASDAQ and the deregistration of Shire ADSs and
Shire Shares under Section 12(b) of the Securities Exchange Act of 1934, as amended (the "
Exchange
Act
"). As a result, Shire ADSs will no longer be listed on NASDAQ. In addition, Shire intends to file a certification on
Form 15 with the SEC requesting the termination of registration of Shire ADSs under Section 12(g) of the Exchange Act and the suspension of Shire's reporting obligations under Sections 13 and 15(d) of the Exchange Act with respect to Shire
ADSs.
Item 3.03
Material Modification to Rights of Security Holders.
The information in Item 2.01 and 3.01 is incorporated by reference herein.
On the Effective Date, Shire's shareholders ceased to have any rights as shareholders of Shire, other than their right to receive the
Consideration.
Item 5.01
Changes in Control of Registrant.
The information in Item 2.01 and 3.01, as well as the information in "Item 5. Operating and Financial Review and Prospects—B.
Liquidity and Capital Resources—Financing Arrangements for the Shire Acquisition" of Takeda's Form
20-F
filed on December 17, 2018, is incorporated by reference herein.
On the Effective Date, a change of control of Shire occurred, and Shire is now a wholly-owned subsidiary of Takeda.
Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain
Officers.
On January 8, 2019, in connection with the Acquisition, Susan Kilsby, Flemming Ornskov, Thomas Dittrich, Olivier
Bohuon, Ian Clark, Gail Fosler, Steven Gillis, David Ginsburg, Sara Mathew and Albert Stroucken resigned and ceased to be members of the Board of Directors of Shire (including any committees thereof) and Bill Mordan resigned and ceased to be company
secretary of Shire. These resignations were not a result of any disagreements between Shire and its directors on any matter relating to Shire's operations, policies or practices. On the Effective Date, the following persons were elected
members of the Board of Directors of Shire: Susan O'Reilly, Amitabh Singh, Anthony Denis Ahern, Nigel Coffey, Paul Keogh, Anthony Grannell, John Ryan and James Dinniss. On the Effective Date, Susan O'Reilly was appointed as secretary of
Shire with immediate effect and Mourant Secretaries (Jersey) Limited was appointed as assistant secretary of Shire with immediate effect.
Mssrs. Bohuon, Clark and Gillis were previously elected to the Board of Directors of Takeda on December 5, 2018, and such appointments
took effect as of the Effective Date.
Pursuant to separation agreements entered into with each of Dr. Ornskov and Mr. Dittrich,
Dr. Ornskov and Mr. Dittrich are each eligible to receive a contract termination payment in an amount equal to the sum of two times each executive's respective base salary payable for the 2018 financial year and two times each
executive's respective target bonus for the 2018 financial year, reduced by the amount paid to each executive under his executive employment agreement, on June 30, 2019. Shire will also cover the reasonable costs of Dr. Ornskov's
health and dental benefits for twelve months from January 8, 2019 and will cover the reasonable costs associated with his repatriation up to a maximum cost of $500,000 should he work in Switzerland as a result of visa considerations.
Item 5.03
Amendments to Articles of Association or Bylaws; Change in Fiscal Year.
The information in Item 2.01 and 3.01 is incorporated by reference herein.
Following the Effectiveness of the Scheme, on January 8, 2019, the Articles of Association of Shire were amended and restated in their
entirety, a copy of which is filed as Exhibit 3.1 to this Form
8-K
and is incorporated by reference herein.
Item 9.01
Financial Statements and Exhibits.
(d)
Exhibits
Exhibit
No.
Description
3.1
Articles of Association of Shire plc as amended and adopted by a special resolution on January 8, 2019.
EXHIBIT INDEX
Exhibit
No.
Description
3.1
Articles of Association of Shire plc as amended and adopted by a special resolution on January 8, 2019.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.
SHIRE PLC
Date: January 8, 2019
By:
/s/ Susan O'Reilly
Name:
Susan O'Reilly
Title:
Company Secretary