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<P align=center><FONT face="Times New Roman, Times, Serif"><FONT
size=4><B>UNITED STATES</B><BR><B>SECURITIES AND EXCHANGE
COMMISSION</B></FONT></FONT><BR><FONT face="Times New Roman, Times, Serif"><FONT
size=2><B>WASHINGTON, D.C. 20549</B><BR></FONT></FONT><BR><FONT
face="Times New Roman, Times, Serif"><FONT size=5><B>
FORM 8-K</B></FONT></FONT></P>

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<P align=center><FONT face="Times New Roman, Times, Serif"><FONT
size=2><B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CURRENT REPORT
</B></FONT></FONT> </P>

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<P align=center><FONT face="Times New Roman, Times, Serif"><FONT
size=3><B>Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934</B></FONT></FONT></P>

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<P align=center><FONT face="Times New Roman, Times, Serif"><FONT
size=3><B>Date of Report (Date of earliest event reported): June 2, 2005
</B></FONT></FONT></P><BR>


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<P align=center><FONT face="Times New Roman, Times, Serif"><FONT size=6>Integrated
Surgical Systems, Inc.</FONT></FONT><BR><FONT
face="Times New Roman, Times, Serif"><FONT size=2>(Exact name of Registrant as specified
in charter)</FONT></FONT> </P><BR>


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    <TH colSpan=2><FONT face="Times New Roman, Times, Serif" size=2></FONT></TH>
    <TH colSpan=2><FONT face="Times New Roman, Times, Serif" size=2></FONT></TH>
    <TH colSpan=2><FONT face="Times New Roman, Times, Serif"
  size=2></FONT></TH></TR>
  <TR vAlign=bottom>
    <TD align=left width="37%"><FONT face="Times New Roman, Times, Serif"
      size=3>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Delaware</B></FONT></TD>
    <TD align=left width="4%"><FONT face="Times New Roman, Times, Serif"
      size=2>&nbsp;</FONT></TD>
    <TD align=left width="30%"><FONT face="Times New Roman, Times, Serif"
      size=3>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>1-12471</B></FONT></TD>
    <TD align=left width="4%"><FONT face="Times New Roman, Times, Serif"
      size=2>&nbsp;</FONT></TD>
    <TD align=left width="23%"><FONT face="Times New Roman, Times, Serif"
      size=3>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>68-0232575</B></FONT></TD>
    <TD align=left width="2%"><FONT face="Times New Roman, Times, Serif"
      size=2>&nbsp;</FONT></TD></TR>
  <TR vAlign=bottom>
    <TD align=left><FONT face="Times New Roman, Times, Serif" size=2>(State or
      other jurisdiction</FONT></TD>
    <TD align=left><FONT face="Times New Roman, Times, Serif"
      size=2>&nbsp;</FONT></TD>
    <TD align=left><FONT face="Times New Roman, Times, Serif"
      size=2>(Commission File Number)</FONT></TD>
    <TD align=left><FONT face="Times New Roman, Times, Serif"
      size=2>&nbsp;</FONT></TD>
    <TD align=center><FONT face="Times New Roman, Times, Serif" size=2>(I.R.S.
      Employer</FONT></TD>
    <TD align=left><FONT face="Times New Roman, Times, Serif"
      size=2>&nbsp;</FONT></TD></TR>
  <TR vAlign=bottom>
    <TD align=left><FONT face="Times New Roman, Times, Serif" size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;of
      incorporation)</FONT></TD>
    <TD align=left><FONT face="Times New Roman, Times, Serif"
      size=2>&nbsp;</FONT></TD>
    <TD align=left><FONT face="Times New Roman, Times, Serif"
size=2></FONT></TD>
    <TD align=left><FONT face="Times New Roman, Times, Serif"
      size=2>&nbsp;</FONT></TD>
    <TD align=left><FONT face="Times New Roman, Times, Serif"
      size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Identification No.)</FONT></TD>
    <TD align=left><FONT face="Times New Roman, Times, Serif"
      size=2>&nbsp;</FONT></TD></TR></TABLE><BR><BR>


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<P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="3"><B>1850 Research Park Drive
Davis, California &nbsp;&nbsp;&nbsp;95616-4884</B><BR>(Address of principal executive
offices)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(Zip Code)</FONT></FONT> </P>


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<P ALIGN="LEFT">
<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Registrant&#146;s telephone number, including area code:&nbsp;&nbsp;&nbsp;<B>(530) 792-2600</B></FONT></FONT> </P>

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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Check the
appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the
filing obligation of the registrant  under any of the following provisions:
</FONT></FONT> </P>

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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">|_|&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Written
communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</FONT></FONT> </P>

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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">|_|&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Soliciting
material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</FONT></FONT> </P>

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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">|_|&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR
240.14d-2(b))</FONT></FONT> </P>

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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">|_|&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR
240.13e-4(c))</FONT></FONT> </P>



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<HR align=center width="100%" color=#999999 SIZE=3>



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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>Item 5.02&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Departure of Directors or Principal Officers; Election of Directors; Appointment of
Principal Officers</B></FONT></FONT> </P>

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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">On June 2,
2005, Jack W. Moorman elected to resign from the board of directors of Integrated
Surgical Systems, Inc. (&quot;ISS&quot;) for  personal reasons.  Mr. Moorman served as a
director of ISS since October 2002.  Mr. Moorman also served as a member of the board's
audit committee and compensation committee.  There were no disagreements between Mr.
Moorman and ISS on any matter relating to ISS  operations, policies or practices.</FONT></FONT> </P>

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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">On
June 2, 2005, Paul A.H. Pankow elected to resign from the board of directors of
ISS for personal reasons. Mr. Pankow served as a director of ISS since January
2003, and previously served as a director of the Company from May 1995 through
December 1999. Mr. Pankow also served as a member of the board&#146;s audit
committee. There were no disagreements between Mr. Pankow and ISS on any matter
relating to ISS operations, policies or practices.</FONT></FONT> </P>

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<A NAME="A009"></A>
<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>Item 8.01&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Other Events</B></FONT></FONT></P>

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<P ALIGN="LEFT">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">On
June 2, 2005, ISS terminated all employees of the Company and ceased operations.
The officers of ISS are evaluating all options available, including securing
additional capital, the sale of assets and the seeking of protection under the
Federal Securities Laws.</FONT></FONT> </P>

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<A NAME="A010"></A>
<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>Item 9.01&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Financial Exhibits and Exhibits</B></FONT></FONT></P>

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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Exhibit
10.1 &#150; Resignation Letter from Jack W. Moorman, dated June 2, 2005. <BR>Exhibit
10.2 &#150; Resignation Letter from Paul A.H. Pankow, dated June 2, 2005.</FONT></FONT> </P>






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<P ALIGN="CENTER"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2"><B>SIGNATURES</B></FONT></FONT></P>

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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Pursuant
to the requirements of the Securities Exchange Act of 1934, the registrant has
duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.</FONT></FONT> </P>



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<P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Dated:&nbsp;&nbsp;&nbsp;&nbsp;
June 10, 2005 </FONT></FONT> </P>



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     <TD WIDTH="50%">&nbsp;</TD>
     <TD><P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">Integrated
Surgical Systems, Inc.</FONT></FONT> </P></TD>
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<BR>

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     <TD WIDTH="50%">&nbsp;</TD>
     <TD><P ALIGN="LEFT"><FONT FACE="Times New Roman, Times, Serif"><FONT SIZE="2">By:&nbsp;&nbsp;&nbsp;&nbsp;<U>/s/ &nbsp;&nbsp;&nbsp;RAMESH C. TRIVEDI</U><BR> Ramesh Trivedi, Chief Executive
Officer</FONT></FONT> </P></TD>
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AutoCoded Document
UNITED STATES
SECURITIES AND EXCHANGE
COMMISSION
WASHINGTON, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): June 2, 2005
Integrated
Surgical Systems, Inc.
(Exact name of Registrant as specified
in charter)
Delaware
1-12471
68-0232575
(State or
      other jurisdiction
(Commission File Number)
(I.R.S.
      Employer
of
      incorporation)
Identification No.)
1850 Research Park Drive
Davis, California    95616-4884
(Address of principal executive
offices)               (Zip Code)
Registrant's telephone number, including area code:
(530) 792-2600
Check the
appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the
filing obligation of the registrant  under any of the following provisions:
|_|      Written
communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
|_|      Soliciting
material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
|_|     
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR
240.14d-2(b))
|_|     
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR
240.13e-4(c))
Item 5.02     
Departure of Directors or Principal Officers; Election of Directors; Appointment of
Principal Officers
On June 2,
2005, Jack W. Moorman elected to resign from the board of directors of Integrated
Surgical Systems, Inc. ("ISS") for  personal reasons.  Mr. Moorman served as a
director of ISS since October 2002.  Mr. Moorman also served as a member of the board's
audit committee and compensation committee.  There were no disagreements between Mr.
Moorman and ISS on any matter relating to ISS  operations, policies or practices.
On
June 2, 2005, Paul A.H. Pankow elected to resign from the board of directors of
ISS for personal reasons. Mr. Pankow served as a director of ISS since January
2003, and previously served as a director of the Company from May 1995 through
December 1999. Mr. Pankow also served as a member of the board's audit
committee. There were no disagreements between Mr. Pankow and ISS on any matter
relating to ISS operations, policies or practices.
Item 8.01     
Other Events
On
June 2, 2005, ISS terminated all employees of the Company and ceased operations.
The officers of ISS are evaluating all options available, including securing
additional capital, the sale of assets and the seeking of protection under the
Federal Securities Laws.
Item 9.01     
Financial Exhibits and Exhibits
Exhibit
10.1 – Resignation Letter from Jack W. Moorman, dated June 2, 2005.
Exhibit
10.2 – Resignation Letter from Paul A.H. Pankow, dated June 2, 2005.
SIGNATURES
Pursuant
to the requirements of the Securities Exchange Act of 1934, the registrant has
duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.
Dated:    
June 10, 2005
Integrated
Surgical Systems, Inc.
By:
/s/    RAMESH C. TRIVEDI
Ramesh Trivedi, Chief Executive
Officer