UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                             CURRENT REPORT PURSUANT
                          TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

      Date of report (Date of earliest event reported): September 20, 2006

                        INTEGRATED SURGICAL SYSTEMS, INC.
         ---------------------------------------------------------------
        (Exact name of small Business Issuer as specified in its charter)

          Delaware                    1-12471                     68-0232575
--------------------------------------------------------------------------------
(State or other jurisdiction        (Commission                 (IRS Employer
     of incorporation)             File Number)              Identification No.)

 6220 Belleau Wood Lane, Suite 4, Sacramento, California             95822
--------------------------------------------------------------------------------
         (Address of principal executive offices)                 (Zip Code)

Registrant's telephone number, including area code (916) 391-0450
                                                   --------------

                                       N/A
--------------------------------------------------------------------------------
          (Former name or former address, if changes since last report)

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

[ ]     Written communications pursuant to Rule 425 under the Securities Act
        (17 CFR 230.425)

[ ]     Soliciting material pursuant to Rule 14a-12 under the Exchange Act
        (17 CFR 240.14a-12)

[ ]     Pre-commencement communications pursuant to Rule 14d-2(b) under the
        Exchange Act (17 CFR 240.14d-2(b))

[ ]     Pre-commencement communications pursuant to Rule 13e-4(c) under the
        Exchange Act (17 CFR 240.13e-4(c))



<PAGE>



Item 4.01.        Changes in Registrant's Certifying Accountant.

On August 15, 2005, Macias Gini & O'Connell LLP ("Macias & Gini") resigned as
the Registrant's independent accountant. During the Registrant's fiscal years
ended December 31, 2004, there were no disagreements with Macias & Gini on any
matter of accounting principles or practices, financial statement disclosure, or
auditing scope or procedures, which, if not resolved to Macias & Gini's
satisfaction, would have caused Macias & Gini to make reference to the subject
matter of the disagreement(s) in connection with its reports.

The audit report of Macias & Gini on the consolidated financial statements of
the Registrant as of and for the fiscal years ended December 31, 2004, did not
contain any adverse opinion or disclaimer of opinion, nor were they qualified or
modified as to uncertainty, audit scope, or accounting principles, except that
the audit reports for such fiscal years contained an explanatory paragraph
indicating that there is substantial doubt about the Registrant's ability to
continue as a going concern.

On September 20, 2006, the Registrant retained Most & Company, LLP ("Most &
Company") as its new independent accountant to audit the financial statements of
the Registrant for the years ended December 31, 2004, 2005 and 2006. During the
Company's two most recent fiscal years, and during the subsequent period through
September 15, 2006, the Company did not consult with Most & Company on any
accounting or auditing issues.

Both the resignation of Macias & Gini and the retention of Most & Company were
discussed with and approved by the Registrant's Board of Directors.


Item 5.02.        Departure of Directors or Principal Officers; Election of
                  Directors; Appointment of Principal Officers.

Dr. Ramesh Trivedi continues to serve the Registrant as its Chief Executive
Officer and Lee Witherspoon also continues to serve the Registrant as its Vice
President of Operations and Chief Technical Officer.

On September 20, 2006, Michael Tomczak was appointed to serve as a Director of
the Registrant. Mr. Tomczak is currently an owner and President of Sequoia
Business Solutions, Inc., which primarily provides consulting and bookkeeping
services to small businesses. He served as Vice President, Chief Financial
Officer and Secretary for the Registrant from 1991 until 1997. Mr. Tomczak
served as Retail Technology International, Inc.'s (RTI) Chief Executive Officer
and President from 2002 until its sale to Island Pacific, Inc in 2004 and was
co-owner during that same time period. RTI was a developer of point-of-sale
software and Island Pacific is a developer of retail management software. Mr.
Tomczak was also Chairman of RTI's Board of Directors during that same period
and had previously served as RTI's Chief Financial Officer from 2001. Upon the
sale of RTI to Island Pacific, he became its President and Chief Operating
Officer until 2005. Mr. Tomczak was a member of Island Pacific's Board of
Directors from 2004 until 2005. Prior to joining the Registrant, Mr. Tomczak
served as director of Ernst & Young's Sacramento office's Entrepreneurial
Services Group. Mr. Tomczak holds a Bachelor of Business Administration degree
from Western Michigan University and has been a Certified Public Accountant in
both California and Michigan.


                                       2

<PAGE>


On September 20, 2006, Peter Mills was appointed to serve as a Director of the
Registrant. Mr. Mills is Vice President of Sales at Speck Design, a leading
product design firm with offices in Palo Alto, California and Shanghai, China.
He has spent 15 years selling sophisticated industrial robotics and automation
systems with Adept Technology, the leading U.S. manufacturer of industrial
robots, and Hewlett-Packard Company. He has also served as the Vice President of
Sales at Softchain, an enterprise supply chain software company acquired in
2001. Mr. Mills has significant experience with respect to the design and
manufacturing needs of a variety of industries including medical devices, disk
drives, consumer products, food packaging, printers, computers and networking,
and semiconductor equipment. He has extensive international business experience
in Japan, Singapore, and Korea. Mr. Mills earned an MBA from Harvard Business
School and an A.B. in engineering, cum laude, from Dartmouth College.

On September 20, 2006, David H. Adams was appointed as the Registrant's Chief
Financial Officer. Mr. Adams had been the Controller of the Registrant since
joining the Registrant early in 2004. From 2003 to 2004, Mr. Adams was the Chief
Financial Officer of Velocity Mobile, a provider of cellular phone equipment and
services. From 2000 to 2003, Mr. Adams was Chief Financial Officer of Unify
Corporation, a software development company. Prior to that, Mr. Adams was Chief
Financial Officer of Commerce Security Bank.

Item 8.01.         Other Events.

As a result of the Registrant securing funding pursuant to the transaction with
Novatrix Biomedical, Inc. (as previously reported), the Registrant has resumed
operations at its new principal offices in Sacramento, California.


                                       3
<PAGE>



                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                               Integrated Surgical Systems, Inc.
                                                         (Registrant)


Dated:  September 20, 2006                     By: /s/ Ramesh Trivedi
                                                   -----------------------------
                                                       Ramesh Trivedi,
                                                       Chief Executive Officer



                                       4
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UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                             CURRENT REPORT PURSUANT
                          TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

      Date of report (Date of earliest event reported): September 20, 2006

                        INTEGRATED SURGICAL SYSTEMS, INC.
         ---------------------------------------------------------------
        (Exact name of small Business Issuer as specified in its charter)

          Delaware                    1-12471                     68-0232575
--------------------------------------------------------------------------------
(State or other jurisdiction        (Commission                 (IRS Employer
     of incorporation)             File Number)              Identification No.)

 6220 Belleau Wood Lane, Suite 4, Sacramento, California             95822
--------------------------------------------------------------------------------
         (Address of principal executive offices)                 (Zip Code)

Registrant's telephone number, including area code (916) 391-0450
                                                   --------------

                                       N/A
--------------------------------------------------------------------------------
          (Former name or former address, if changes since last report)

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

[ ]     Written communications pursuant to Rule 425 under the Securities Act
        (17 CFR 230.425)

[ ]     Soliciting material pursuant to Rule 14a-12 under the Exchange Act
        (17 CFR 240.14a-12)

[ ]     Pre-commencement communications pursuant to Rule 14d-2(b) under the
        Exchange Act (17 CFR 240.14d-2(b))

[ ]     Pre-commencement communications pursuant to Rule 13e-4(c) under the
        Exchange Act (17 CFR 240.13e-4(c))
Item 4.01.        Changes in Registrant's Certifying Accountant.

On August 15, 2005, Macias Gini & O'Connell LLP ("Macias & Gini") resigned as
the Registrant's independent accountant. During the Registrant's fiscal years
ended December 31, 2004, there were no disagreements with Macias & Gini on any
matter of accounting principles or practices, financial statement disclosure, or
auditing scope or procedures, which, if not resolved to Macias & Gini's
satisfaction, would have caused Macias & Gini to make reference to the subject
matter of the disagreement(s) in connection with its reports.

The audit report of Macias & Gini on the consolidated financial statements of
the Registrant as of and for the fiscal years ended December 31, 2004, did not
contain any adverse opinion or disclaimer of opinion, nor were they qualified or
modified as to uncertainty, audit scope, or accounting principles, except that
the audit reports for such fiscal years contained an explanatory paragraph
indicating that there is substantial doubt about the Registrant's ability to
continue as a going concern.

On September 20, 2006, the Registrant retained Most & Company, LLP ("Most &
Company") as its new independent accountant to audit the financial statements of
the Registrant for the years ended December 31, 2004, 2005 and 2006. During the
Company's two most recent fiscal years, and during the subsequent period through
September 15, 2006, the Company did not consult with Most & Company on any
accounting or auditing issues.

Both the resignation of Macias & Gini and the retention of Most & Company were
discussed with and approved by the Registrant's Board of Directors.

Item 5.02.        Departure of Directors or Principal Officers; Election of
                  Directors; Appointment of Principal Officers.

Dr. Ramesh Trivedi continues to serve the Registrant as its Chief Executive
Officer and Lee Witherspoon also continues to serve the Registrant as its Vice
President of Operations and Chief Technical Officer.

On September 20, 2006, Michael Tomczak was appointed to serve as a Director of
the Registrant. Mr. Tomczak is currently an owner and President of Sequoia
Business Solutions, Inc., which primarily provides consulting and bookkeeping
services to small businesses. He served as Vice President, Chief Financial
Officer and Secretary for the Registrant from 1991 until 1997. Mr. Tomczak
served as Retail Technology International, Inc.'s (RTI) Chief Executive Officer
and President from 2002 until its sale to Island Pacific, Inc in 2004 and was
co-owner during that same time period. RTI was a developer of point-of-sale
software and Island Pacific is a developer of retail management software. Mr.
Tomczak was also Chairman of RTI's Board of Directors during that same period
and had previously served as RTI's Chief Financial Officer from 2001. Upon the
sale of RTI to Island Pacific, he became its President and Chief Operating
Officer until 2005. Mr. Tomczak was a member of Island Pacific's Board of
Directors from 2004 until 2005. Prior to joining the Registrant, Mr. Tomczak
served as director of Ernst & Young's Sacramento office's Entrepreneurial
Services Group. Mr. Tomczak holds a Bachelor of Business Administration degree
from Western Michigan University and has been a Certified Public Accountant in
both California and Michigan.

                                       2
On September 20, 2006, Peter Mills was appointed to serve as a Director of the
Registrant. Mr. Mills is Vice President of Sales at Speck Design, a leading
product design firm with offices in Palo Alto, California and Shanghai, China.
He has spent 15 years selling sophisticated industrial robotics and automation
systems with Adept Technology, the leading U.S. manufacturer of industrial
robots, and Hewlett-Packard Company. He has also served as the Vice President of
Sales at Softchain, an enterprise supply chain software company acquired in
2001. Mr. Mills has significant experience with respect to the design and
manufacturing needs of a variety of industries including medical devices, disk
drives, consumer products, food packaging, printers, computers and networking,
and semiconductor equipment. He has extensive international business experience
in Japan, Singapore, and Korea. Mr. Mills earned an MBA from Harvard Business
School and an A.B. in engineering, cum laude, from Dartmouth College.

On September 20, 2006, David H. Adams was appointed as the Registrant's Chief
Financial Officer. Mr. Adams had been the Controller of the Registrant since
joining the Registrant early in 2004. From 2003 to 2004, Mr. Adams was the Chief
Financial Officer of Velocity Mobile, a provider of cellular phone equipment and
services. From 2000 to 2003, Mr. Adams was Chief Financial Officer of Unify
Corporation, a software development company. Prior to that, Mr. Adams was Chief
Financial Officer of Commerce Security Bank.

Item 8.01.         Other Events.

As a result of the Registrant securing funding pursuant to the transaction with
Novatrix Biomedical, Inc. (as previously reported), the Registrant has resumed
operations at its new principal offices in Sacramento, California.

                                       3
SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                               Integrated Surgical Systems, Inc.
                                                         (Registrant)

Dated:  September 20, 2006                     By: /s/ Ramesh Trivedi
                                                   -----------------------------
                                                       Ramesh Trivedi,
                                                       Chief Executive Officer

                                       4