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<title>Form 8-K
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<font face="Times New Roman, Times, Serif" size=5><b>UNITED STATES<br>
SECURITIES AND EXCHANGE COMMISSION<br></b></font>
<font face="Times New Roman, Times, Serif" size=2>Washington, DC 20549</font>
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<font face="Times New Roman, Times, Serif" size=5><b>FORM 8-K<br>
<br></b></font></p>
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<font face="Times New Roman, Times, Serif" size=5><b>CURRENT REPORT</b></font><br><font face="Times New Roman, Times, Serif" size=2><b>Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934<br></b></font></p>
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<font face="Times New Roman, Times, Serif" size=2>Date of Report&nbsp;&nbsp;(Date of earliest event reported):&nbsp;&nbsp;&nbsp;&nbsp;September 29, 2004</font><br></p>
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<font face="Times New Roman, Times, Serif" size=5><b>MILLENNIUM PHARMACEUTICALS, INC.</b></font><br><font face="Times New Roman, Times, Serif" size=2>(Exact name of registrant as specified in its charter)</font></p>
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<td width=33% align=center valign=top><font face="Times New Roman, Times, Serif" size=2><b>Delaware</b></font></td>
<td width=34% align=center valign=top><font face="Times New Roman, Times, Serif" size=2><b>0-28494</b></font></td>
<td width=33% align=center valign=top><font face="Times New Roman, Times, Serif" size=2><b>04-3177038</b></font></td>
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<td width=33% align=center valign=top><font face="Times New Roman, Times, Serif" size=2>(State or other jurisdiction<br>of incorporation)</font></td>
<td width=34% align=center valign=top><font face="Times New Roman, Times, Serif" size=2>(Commission file number)</font></td>
<td width=33% align=center valign=top><font face="Times New Roman, Times, Serif" size=2>(IRS&nbsp;Employer<br>Identification&nbsp;No.)</font></td>
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<p align=center><font face="Times New Roman, Times, Serif" size=2><b>40 Landsdowne Street<br>Cambridge, Massachusetts 02139</b><br>
(Address of principal executive offices)&nbsp;(zip code)</font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2><b>(617)&nbsp;&nbsp;679-7000<br></b>
(Registrant's telephone number, including area code)</font></p>

<p align=center><font face="Times New Roman, Times, Serif" size=2><b>Not applicable<br></b>
(Former name or former address if changed since last report)</font></p>

<p align=left><font face="Times New Roman, Times, Serif" size=2>Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy
the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):</font></p>

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<td align=right valign=top width=3%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=right valign=top width=1%><font face="Times New Roman, Times, Serif" size=2>&#144;</font></td>
<td align=right valign=top width=2%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=left valign=top width=94%><font face="Times New Roman, Times, Serif" size=2>Written communications
pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</font></td>
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<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
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<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&#144;</font></td>
<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=left valign=bottom><font face="Times New Roman, Times, Serif" size=2>Soliciting material pursuant to Rule
14a-12 under the Exchange Act (17 CFR 240.14a-12)</font></td>
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<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
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<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&#144;</font></td>
<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=left valign=bottom><font face="Times New Roman, Times, Serif" size=2>Pre-commencement communications pursuant
to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</font></td></tr>
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<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
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<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
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<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=left valign=bottom><font face="Times New Roman, Times, Serif" size=2>Pre-commencement communications pursuant to Rule 13e-4(c)
under the Exchange Act (17 CFR 240.13e-4(c))</font></td></tr>
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<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=right valign=top><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
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<td width=9%><font face="Times New Roman, Times, Serif" size=2><b>Item&nbsp;&nbsp;&nbsp;1.01.</b></font></td>
<td width=3%>&nbsp;</td>
<td width=68% align=left><font face="Times New Roman, Times, Serif" size=2><b>Entry into a Material Definitive Agreement.</b></font></td>
<td width=20% align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
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<p align=left><font face="Times New Roman, Times, Serif" size=2>On September 29, 2004, Laurie B.
Keating was appointed Senior Vice President, General Counsel and Secretary of Millennium
Pharmaceuticals, Inc. Millennium entered into an offer letter agreement with Ms. Keating
on September 28, 2004. Ms. Keating&#146;s employment with Millennium is at-will and may be
terminated by Millennium at any time with or without cause. If her employment with
Millennium is terminated by Millennium without Justifiable Cause or by her for Good
Reason (each as defined in the agreement) then, subject to certain conditions, Millennium is
obligated to pay her severance payments equal to twelve months&#146; salary.</FONT></P>



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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>On September 30, 2004, Millennium
granted, under the terms of its 2000 Stock Incentive Plan, an option to purchase 50,000
shares of Millennium common stock, $.001 par value per share, to Ms. Keating at an option
exercise price of $13.67 per share. The option becomes exercisable for one-quarter of the
number of shares subject to the option on September 29, 2005 and for one-forty-eighth of
the number of shares subject to the option monthly beginning on October 29, 2005. The
option is an incentive stock option to the extent permitted under the Internal Revenue
Code of 1986, as amended, with any amount in excess of permitted levels under the Code to
be treated as a non-statutory stock option to the extent of such excess. </FONT></P>

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<P><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Under the 2000 Plan, each option
becomes fully vested in the event of the death of the option holder. The 2000 Plan
provides for full vesting of options to option holders who terminate their employment for
good reason or are terminated without cause during the period one month before through one
year after a change in control. Each option terminates on the earlier of (i) ten years
from the date of grant or (ii) the date three months after the option holder ceases to
serve as a director or employee (except in the case of disability, the date one year after
the date of disability, in the event of death, the date three years after the date of
death and if the option holder retires after ten years of employment and is at least 55
years of age, the date three years after the date of retirement). Copies of the
forms of terms of the incentive stock option and non-statutory stock option are
incorporated by reference to Exhibit No. 99.2 and Exhibit No. 99.3 filed with
this Current Report on Form 8-K.</FONT></P>






<p align=left><font face="Times New Roman, Times, Serif" size=2><b>Item&nbsp;&nbsp;&nbsp;&nbsp;9.01&nbsp;&nbsp;&nbsp;&nbsp;Financial
Statements and Exhibits.</b></font></p>

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<td align=left width=20%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=left width=10%><font face="Times New Roman, Times, Serif" size=2>(c)</font></td>
<td align=left width=70%><font face="Times New Roman, Times, Serif" size=2>Exhibits</font></td>
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<td align=left width=20%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=10%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=left width=70%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
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<td width=20%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=10%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=70%><font face="Times New Roman, Times, Serif" size=2>See Exhibit Index attached to this Current Report on Form 8-K.</font></td>
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<td align=left width=20%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=10%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td align=left width=70%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
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<p align=center><font face="Times New Roman, Times, Serif" size=2>2</font></p>
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<p align=center><FONT FACE="Times New Roman, Times, Serif" SIZE=2><b><a name="sig">SIGNATURE</a></b></font></p>

<p><FONT FACE="Times New Roman, Times, Serif" SIZE=2>Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its
behalf by the undersigned hereunto duly authorized.</font></p>




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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td colspan=2><font face="Times New Roman, Times, Serif" size=2>MILLENNIUM PHARMACEUTICALS, INC.<br>(Registrant)<br><br></font></td>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Date: October 5, 2004&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>By&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2>/s/&nbsp;&nbsp;MARSHA H. FANUCCI</font></td>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2></font><hr noshade></td>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2>Marsha H. Fanucci</font></td>
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<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=30%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=4%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=36% align=left><font face="Times New Roman, Times, Serif" size=2>Senior Vice President and Chief Financial Officer</font></td>
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<p align=center><font face="Times New Roman, Times, Serif" size=2>3</font></p>
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<p><font face="Times New Roman, Times, Serif" size=2><b><a name="index">EXHIBIT INDEX</a></b></font></p>

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<tr valign=bottom>
<th width=9% align=center colspan=2><font face="Times New Roman, Times, Serif" size=2>Exhibit No.<br></font><hr noshade></th>
<th width=3%>&nbsp;</th>
<th width=68% align=center><font face="Times New Roman, Times, Serif" size=2>Description<br></font><hr noshade></th>
<th width=20% align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></th>
</tr>
<tr valign=top>
<td width=3%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=6%><font face="Times New Roman, Times, Serif" size=2>99.1</font></td>
<td width=3%>&nbsp;</td>
<td width=68% align=left><font face="Times New Roman, Times, Serif" size=2>2000 Stock Incentive
Plan, as amended (incorporated by reference to Exhibit 10.14 of the Company&#146;s Form 10-K for the fiscal year ended
December 31, 2002 filed on March 7, 2003)
</font></td>
<td width=20% align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
</tr>
<tr valign=top>
<td width=3%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=6%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=3%>&nbsp;</td>
<td width=68% align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=20% align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
</tr>
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<td width=3%><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td width=6%><font face="Times New Roman, Times, Serif" size=2>99.2</font></td>
<td width=3%>&nbsp;</td>
<td width=68% align=left><font face="Times New Roman, Times, Serif" size=2>Form of Terms of Incentive Stock Option Granted Under 2000 Stock Incentive Plan</font></td>
<td width=20% align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
</tr>
<tr valign=top>
<td><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td>&nbsp;</td>
<td><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
</tr>
<tr valign=top>
<td><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
<td><font face="Times New Roman, Times, Serif" size=2>99.3</font></td>
<td>&nbsp;</td>
<td align=left><font face="Times New Roman, Times, Serif" size=2>Form of Terms of Non-Statutory Stock Option Granted Under 2000 Stock Incentive Plan (incorporated
                                    by reference to Exhibit 99.2 of the Company's Form 8-K filed on September 7, 2004)</font></td>
<td align=left><font face="Times New Roman, Times, Serif" size=2>&nbsp;</font></td>
</tr>
</table>




<p align=center><font face="Times New Roman, Times, Serif" size=2>4</font></p>
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Form 8-K
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report  (Date of earliest event reported):    September 29, 2004
MILLENNIUM PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)
Delaware
0-28494
04-3177038
(State or other jurisdiction
of incorporation)
(Commission file number)
(IRS Employer
Identification No.)
40 Landsdowne Street
Cambridge, Massachusetts 02139
(Address of principal executive offices) (zip code)
(617)  679-7000
(Registrant's telephone number, including area code)
Not applicable
(Former name or former address if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy
the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

Written communications
pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

Soliciting material pursuant to Rule
14a-12 under the Exchange Act (17 CFR 240.14a-12)

Pre-commencement communications pursuant
to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

Pre-commencement communications pursuant to Rule 13e-4(c)
under the Exchange Act (17 CFR 240.13e-4(c))
Item   1.01.
Entry into a Material Definitive Agreement.
On September 29, 2004, Laurie B.
Keating was appointed Senior Vice President, General Counsel and Secretary of Millennium
Pharmaceuticals, Inc. Millennium entered into an offer letter agreement with Ms. Keating
on September 28, 2004. Ms. Keating's employment with Millennium is at-will and may be
terminated by Millennium at any time with or without cause. If her employment with
Millennium is terminated by Millennium without Justifiable Cause or by her for Good
Reason (each as defined in the agreement) then, subject to certain conditions, Millennium is
obligated to pay her severance payments equal to twelve months' salary.
On September 30, 2004, Millennium
granted, under the terms of its 2000 Stock Incentive Plan, an option to purchase 50,000
shares of Millennium common stock, $.001 par value per share, to Ms. Keating at an option
exercise price of $13.67 per share. The option becomes exercisable for one-quarter of the
number of shares subject to the option on September 29, 2005 and for one-forty-eighth of
the number of shares subject to the option monthly beginning on October 29, 2005. The
option is an incentive stock option to the extent permitted under the Internal Revenue
Code of 1986, as amended, with any amount in excess of permitted levels under the Code to
be treated as a non-statutory stock option to the extent of such excess.
Under the 2000 Plan, each option
becomes fully vested in the event of the death of the option holder. The 2000 Plan
provides for full vesting of options to option holders who terminate their employment for
good reason or are terminated without cause during the period one month before through one
year after a change in control. Each option terminates on the earlier of (i) ten years
from the date of grant or (ii) the date three months after the option holder ceases to
serve as a director or employee (except in the case of disability, the date one year after
the date of disability, in the event of death, the date three years after the date of
death and if the option holder retires after ten years of employment and is at least 55
years of age, the date three years after the date of retirement). Copies of the
forms of terms of the incentive stock option and non-statutory stock option are
incorporated by reference to Exhibit No. 99.2 and Exhibit No. 99.3 filed with
this Current Report on Form 8-K.
Item    9.01    Financial
Statements and Exhibits.
(c)
Exhibits
See Exhibit Index attached to this Current Report on Form 8-K.
2
SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its
behalf by the undersigned hereunto duly authorized.
MILLENNIUM PHARMACEUTICALS, INC.
(Registrant)
Date: October 5, 2004
By
/s/  MARSHA H. FANUCCI
Marsha H. Fanucci
Senior Vice President and Chief Financial Officer
3
EXHIBIT INDEX
Exhibit No.
Description
99.1
2000 Stock Incentive
Plan, as amended (incorporated by reference to Exhibit 10.14 of the Company's Form 10-K for the fiscal year ended
December 31, 2002 filed on March 7, 2003)
99.2
Form of Terms of Incentive Stock Option Granted Under 2000 Stock Incentive Plan
99.3
Form of Terms of Non-Statutory Stock Option Granted Under 2000 Stock Incentive Plan (incorporated
                                    by reference to Exhibit 99.2 of the Company's Form 8-K filed on September 7, 2004)
4