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<B><P ALIGN="CENTER">UNITED STATES<br>
SECURITIES AND EXCHANGE COMMISSION<br>
Washington, D.C. 20549</P></B>

<B><P ALIGN="CENTER">FORM 8-K</P></B>

<B><P ALIGN="CENTER">CURRENT REPORT<br>
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934</P></B>

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<B><P ALIGN="CENTER">August 13, 2003<br>
</B>Date of Report (Date of earliest event reported) </TD>
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<B><P ALIGN="CENTER">ORAGENICS, INC.<br>
</B>(Exact name of registrant as specified in its charter)</TD>
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<B><P ALIGN="CENTER">Florida</B></TD>
<TD WIDTH="32%" VALIGN="TOP">

<B><P ALIGN="CENTER">333-100568</B></TD>
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<B><P ALIGN="CENTER">59-3410522</B></TD>
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<P ALIGN="CENTER">(State or other jurisdiction<br>
of incorporation)</TD>
<TD WIDTH="32%" VALIGN="TOP">

<P ALIGN="CENTER">(Commission<br>
File Number)</TD>
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<P ALIGN="CENTER">(IRS Employer<br>
Identification No.)</TD>
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<B><P ALIGN="CENTER">12085 Research Drive<br>
Alachua, Florida 32615<br>
</B>(Address of principal executive offices including zip code)</TD>
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<B><P ALIGN="CENTER">(386) 418-4018<br>
</B>Registrant's telephone number, including area code</TD>
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<B><P ALIGN="CENTER">None<br>
</B>(Former name or former address, if changed since last report.)</TD>
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<B><P>ITEM 7. &nbsp; &nbsp; FINANCIAL INFORMATION AND EXHIBITS</P></B>

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<B><P>Exhibit No.</B></TD>
<TD WIDTH="76%" VALIGN="TOP">
<B>
<P>Description</B></TD>
</TR>
<TR><TD WIDTH="24%" VALIGN="TOP">
<B>
</B><P>99.1</TD>
<TD WIDTH="76%" VALIGN="TOP">

<P>Press Release</TD>
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<br><B><P>ITEM 9. &nbsp; &nbsp; REGULATION FD DISCLOSURE</P></B>

<P>The Company announced that it had filed a patent application with the United States Patent and Trademark Office covering its probiotic based technology.  A copy of the press release is filed as an exhibit to this Form 8-K.</P>

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<B><P ALIGN="CENTER">SIGNATURES</P></B>

<P>In accordance with the requirements of the Exchange Act, the registrant caused this report to be signed on its behalf by the undersigned, thereunto duly authorized on this 13<SUP>th</SUP> day of August, 2003.</P>

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<P>&nbsp;</TD>
<TD WIDTH="62%" VALIGN="TOP" COLSPAN=2>

<B><P>ORAGENICS, INC.<br>
(Registrant)</B></TD>
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<P>&nbsp;</TD>
<TD WIDTH="7%" VALIGN="TOP"><br>

<P>BY:</TD>
<TD WIDTH="55%" VALIGN="TOP"><br>

<P>/s/ Mento A. Soponis</TD>
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<P>&nbsp;</TD>
<TD WIDTH="7%" VALIGN="TOP">

<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">

<P>Mento A. Soponis<br
<P>President, Principal Executive Officer and a member of the Board of Directors.</TD>
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{"company-data": {"conformed-name": "ORAGENICS INC", "cik": "0001174940", "assigned-sic": "2834", "irs-number": "593410522", "state-of-incorporation": "FL", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "333-100568", "film-number": "03842772"}, "business-address": {"street1": "12085 RESEARCH DRIVE", "city": "ALACHUA", "state": "FL", "zip": "32615", "phone": "3864184018"}, "mail-address": {"street1": "12085 RESEARCH DRIVE", "city": "ALACHUA", "state": "FL", "zip": "32615"}}
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
August 13, 2003
Date of Report (Date of earliest event reported)
ORAGENICS, INC.
(Exact name of registrant as specified in its charter)
Florida
333-100568
59-3410522
(State or other jurisdiction
of incorporation)
(Commission
File Number)
(IRS Employer
Identification No.)
12085 Research Drive
Alachua, Florida 32615
(Address of principal executive offices including zip code)
(386) 418-4018
Registrant's telephone number, including area code
None
(Former name or former address, if changed since last report.)
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ITEM 7.     FINANCIAL INFORMATION AND EXHIBITS
Exhibit No.
Description
99.1
Press Release
ITEM 9.     REGULATION FD DISCLOSURE
The Company announced that it had filed a patent application with the United States Patent and Trademark Office covering its probiotic based technology.  A copy of the press release is filed as an exhibit to this Form 8-K.
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SIGNATURES
In accordance with the requirements of the Exchange Act, the registrant caused this report to be signed on its behalf by the undersigned, thereunto duly authorized on this 13
th
day of August, 2003.
ORAGENICS, INC.
(Registrant)
BY:
/s/ Mento A. Soponis
Mento A. Soponis
President, Principal Executive Officer and a member of the Board of Directors.
- 3 -