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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 12pt/0.75pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>FORM 8-K</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Current Report Pursuant</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>to Section 13 or 15(d) of the</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Securities Exchange Act of 1934</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Date of Report (Date of earliest event reported)
December 5, 2012</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 24pt Times New Roman, Times, Serif; margin: 0; text-align: center">PRESSURE BIOSCIENCES, INC.</P>

<P STYLE="font: 12pt/1.5pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">(Exact Name of Registrant as Specified
in its Charter)</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">MASSACHUSETTS</P>

<P STYLE="font: 12pt/1.5pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">&nbsp; (State or Other Jurisdiction
of Incorporation)</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR>
    <TD STYLE="width: 41%; border-bottom: black 1.5pt solid; padding-right: 0.8pt; text-align: center">&nbsp; 0-21615</TD>
    <TD STYLE="width: 19%; border-bottom: white 9pt double; padding-right: 0.8pt">&nbsp;</TD>
    <TD STYLE="width: 40%; border-bottom: black 1.5pt solid; padding-right: 0.8pt; text-align: center">&nbsp; 04-2652826</TD></TR>
<TR>
    <TD STYLE="padding-right: 0.8pt; text-align: center">&nbsp; (Commission File Number)</TD>
    <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
    <TD STYLE="padding-right: 0.8pt; text-align: center">&nbsp;&nbsp; (IRS Employer Identification No.)</TD></TR>
</TABLE>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR>
    <TD STYLE="width: 41%; border-bottom: black 1.5pt solid; padding-right: 0.8pt; text-align: center">&nbsp; 14 Norfolk Avenue, South Easton, MA</TD>
    <TD STYLE="width: 19%; border-bottom: white 9pt double; padding-right: 0.8pt">&nbsp;</TD>
    <TD STYLE="width: 40%; border-bottom: black 1.5pt solid; padding-right: 0.8pt; text-align: center">02375</TD></TR>
<TR>
    <TD STYLE="padding-right: 0.8pt; text-align: center">(Address of Principal Executive Offices)</TD>
    <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
    <TD STYLE="padding-right: 0.8pt; text-align: center">&nbsp;&nbsp; (Zip Code)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(508) 230-1828</P>

<P STYLE="font: 12pt/1.5pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">(Registrant&#8217;s Telephone Number,
Including Area Code)</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 12pt/1.5pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">(Former Name or Former Address, if Changed
Since Last Report)</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions ( <I>see</I> General Instruction
A.2. below):</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; padding-right: 0.8pt; font-family: Wingdings">o</TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</TD></TR>
</TABLE>
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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; padding-right: 0.8pt; font-family: Wingdings">o</TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</TD></TR>
</TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; padding-right: 0.8pt; font-family: Wingdings">o</TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</TD></TR>
</TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; padding-right: 0.8pt; font-family: Wingdings">o</TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt/0.05pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 12pt/0.75pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 12pt/3pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center; background-color: black">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8.5pt 0 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-right: 0; margin-left: 0"><B>Item 5.02 Departure of Directors or Certain
Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">On
December 5, 2012, <B>Pressure BioSciences, Inc. (OTCQB: PBIO)</B> (&#8220;PBI&#8221; or the &#8220;Company&#8221;) announced that
Mr. Conrad F. Mir has joined the Company as its chief financial officer (&#8220;CFO&#8221;), effective immediately. Mr. Mir will
receive an annual salary of $150,000. He is eligible to receive all benefits offered to full-time PBI employees. He will be included
in all stock option awards granted to officers of PBI as voted by the Board of Directors; his award level will be commensurate
with his position in the Company. Mr. Mir will be eligible to receive a bonus based on the successful completion of his responsibilities
as CFO, including his success in raising funds for the Company. The terms of the bonus have not yet been determined.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font-size: 10pt">Mr. Mir has
over twenty years experience in investment banking, financial structuring, and corporate reengineering. He has served in various
executive management roles and on the Board of Directors of several companies in the biotechnology industry. From June 2011 to
October 2012, Mr. Mir was chairman and CEO of Genetic Immunity, Inc. (GI), a plasmid, DNA company in the HIV space. From November
2008 to June 2011, Mr. Mir served as executive director of Advaxis, Inc., a vaccine company. During his tenure at
GI and Advaxis, Mr. Mir was responsible for raising nearly $40 million in growth capital and broadening corporate reach to new
investors and current shareholders.</FONT></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font-size: 10pt">Prior to GI
and Advaxis, Mr. Mir worked for several investment banks including Sanford C. Bernstein, First Liberty Investment Group, and Nomura
Securities International. He holds a BA/BS in Economics and English with special concentrations in Mathematics and Physics from
New York University. He is a classically trained pianist and teacher, and a student of martial arts. He is married with two children,
the alumni council chairman of Tau Kappa Epsilon fraternity &ndash; Tau Alpha chapter (NYU), and a member of NIRI. Mr. Mir is
44 years of age.</FONT></P>



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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><B>Item 9.01&#9;Financial Statements and Exhibits</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><B>(d)&#9;Exhibits</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">99.1&#9;Pressure BioSciences, Inc. Press Release
dated December 5, 2012</P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 9pt/0.05pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0; text-align: center">-2-</P>

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<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 9pt 0 0">&nbsp;</P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: right">&nbsp;</P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B><U>SIGNATURES</U></B></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0">Pursuant to the requirements of the Securities Exchange Act of 1934,
the Registrant has duly caused this Report to be signed on its behalf by the undersigned, thereunto duly authorized.</P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 49%; padding-right: 0.8pt; font: 9pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 6%; padding-right: 0.8pt; font: 9pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 45%; padding-right: 0.8pt; font: 9pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 9pt Times New Roman, Times, Serif; padding-right: 0.8pt">Dated: December 5, 2012</TD>
    <TD COLSPAN="2" STYLE="font: bold 9pt Times New Roman, Times, Serif; padding-right: 1.8pt">PRESSURE BIOSCIENCES, INC.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>
        <P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P>
        <P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P></TD>
    <TD>
        <P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P>
        <P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P></TD>
    <TD>
        <P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P>
        <P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 9pt Times New Roman, Times, Serif; padding-right: 0.8pt">&nbsp;</TD>
    <TD STYLE="font: 9pt Times New Roman, Times, Serif; padding-right: 0.8pt">By:&nbsp;&nbsp;</TD>
    <TD>
        <P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">/s/&nbsp;Richard T. Schumacher</P>
        <P STYLE="font: 9pt/1.5pt Times New Roman, Times, Serif; margin: 8.5pt 53.5pt 0 0; background-color: black">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font: 9pt Times New Roman, Times, Serif; padding-right: 1.8pt">&nbsp;</TD>
    <TD>
        <P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">Richard T. Schumacher,</P>
        <P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">President and Chief Executive Officer</P>
        <P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P></TD></TR>
</TABLE>
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<P STYLE="font: 9pt/0.05pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: right">&nbsp;</P>

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{"company-data": {"conformed-name": "PRESSURE BIOSCIENCES INC", "cik": "0000830656", "assigned-sic": "3826", "irs-number": "042652826", "state-of-incorporation": "MA", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-21615", "film-number": "121255289"}, "business-address": {"street1": "14 NORFOLK AVENUE", "city": "SOUTH EASTON", "state": "MA", "zip": "02375", "phone": "5082301828"}, "mail-address": {"street1": "14 NORFOLK AVENUE", "city": "SOUTH EASTON", "state": "MA", "zip": "02375"}, "former-company": {"former-conformed-name": "BOSTON BIOMEDICA INC", "date-changed": "19960812"}}
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
Current Report Pursuant
to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of Report (Date of earliest event reported)
December 5, 2012
PRESSURE BIOSCIENCES, INC.
(Exact Name of Registrant as Specified
in its Charter)
MASSACHUSETTS
(State or Other Jurisdiction
of Incorporation)
0-21615
04-2652826
(Commission File Number)
(IRS Employer Identification No.)
14 Norfolk Avenue, South Easton, MA
02375
(Address of Principal Executive Offices)
(Zip Code)
(508) 230-1828
(Registrant's Telephone Number,
Including Area Code)
(Former Name or Former Address, if Changed
Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (
see
General Instruction
A.2. below):
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 5.02 Departure of Directors or Certain
Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
On
December 5, 2012,
Pressure BioSciences, Inc. (OTCQB: PBIO)
("PBI" or the "Company") announced that
Mr. Conrad F. Mir has joined the Company as its chief financial officer ("CFO"), effective immediately. Mr. Mir will
receive an annual salary of $150,000. He is eligible to receive all benefits offered to full-time PBI employees. He will be included
in all stock option awards granted to officers of PBI as voted by the Board of Directors; his award level will be commensurate
with his position in the Company. Mr. Mir will be eligible to receive a bonus based on the successful completion of his responsibilities
as CFO, including his success in raising funds for the Company. The terms of the bonus have not yet been determined.
Mr. Mir has
over twenty years experience in investment banking, financial structuring, and corporate reengineering. He has served in various
executive management roles and on the Board of Directors of several companies in the biotechnology industry. From June 2011 to
October 2012, Mr. Mir was chairman and CEO of Genetic Immunity, Inc. (GI), a plasmid, DNA company in the HIV space. From November
2008 to June 2011, Mr. Mir served as executive director of Advaxis, Inc., a vaccine company. During his tenure at
GI and Advaxis, Mr. Mir was responsible for raising nearly $40 million in growth capital and broadening corporate reach to new
investors and current shareholders.
Prior to GI
and Advaxis, Mr. Mir worked for several investment banks including Sanford C. Bernstein, First Liberty Investment Group, and Nomura
Securities International. He holds a BA/BS in Economics and English with special concentrations in Mathematics and Physics from
New York University. He is a classically trained pianist and teacher, and a student of martial arts. He is married with two children,
the alumni council chairman of Tau Kappa Epsilon fraternity – Tau Alpha chapter (NYU), and a member of NIRI. Mr. Mir is
44 years of age.
Item 9.01	Financial Statements and Exhibits
(d)	Exhibits
99.1	Pressure BioSciences, Inc. Press Release
dated December 5, 2012
-2-
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934,
the Registrant has duly caused this Report to be signed on its behalf by the undersigned, thereunto duly authorized.
Dated: December 5, 2012
PRESSURE BIOSCIENCES, INC.
By:
/s/ Richard T. Schumacher
Richard T. Schumacher,
President and Chief Executive Officer
-3-