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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>FORM 8-K</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Current Report Pursuant</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>to Section 13 or 15(d) of the</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Securities Exchange Act of 1934</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Date of Report (Date of earliest event reported)
December 28, 2012</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 24pt Times New Roman, Times, Serif; margin: 0; text-align: center">PRESSURE BIOSCIENCES, INC.</P>

<P STYLE="font: 12pt/1.5pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">(Exact Name of Registrant as Specified
in its Charter)</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">MASSACHUSETTS</P>

<P STYLE="font: 12pt/1.5pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">&nbsp; (State or Other Jurisdiction
of Incorporation)</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="width: 40%; border-bottom: black 1.5pt solid; text-align: center">&nbsp; 0-21615</TD>
    <TD STYLE="width: 12%; border-bottom: white 9pt double">&nbsp;</TD>
    <TD STYLE="width: 48%; border-bottom: black 1.5pt solid; text-align: center">&nbsp; 04-2652826</TD></TR>
<TR>
    <TD STYLE="padding-right: 0.8pt; text-align: center">&nbsp; (Commission File Number)</TD>
    <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
    <TD STYLE="padding-right: 0.8pt; text-align: center">&nbsp;&nbsp; (IRS Employer Identification No.)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="width: 40%; border-bottom: black 1.5pt solid; text-align: center">&nbsp; 14 Norfolk Avenue, South Easton, MA</TD>
    <TD STYLE="width: 12%; border-bottom: white 9pt double">&nbsp;</TD>
    <TD STYLE="width: 48%; border-bottom: black 1.5pt solid; text-align: center">02375</TD></TR>
<TR>
    <TD STYLE="padding-right: 0.8pt; text-align: center">(Address of Principal Executive Offices)</TD>
    <TD STYLE="padding-right: 0.8pt">&nbsp;</TD>
    <TD STYLE="padding-right: 0.8pt; text-align: center">&nbsp;&nbsp; (Zip Code)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(508) 230-1828</P>

<P STYLE="font: 12pt/1.5pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">(Registrant&#8217;s Telephone Number,
Including Area Code)</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 12pt/1.5pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">(Former Name or Former Address, if Changed
Since Last Report)</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions ( <I>see</I> General Instruction
A.2. below):</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; padding-right: 0.8pt; font-family: Wingdings">o</TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</TD></TR>
</TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; padding-right: 0.8pt; font-family: Wingdings">o</TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</TD></TR>
</TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; padding-right: 0.8pt; font-family: Wingdings">o</TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</TD></TR>
</TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; padding-right: 0.8pt; font-family: Wingdings"><FONT STYLE="font: 10pt Wingdings">o</FONT></TD>
    <TD STYLE="width: 96%; padding-right: 0.8pt">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 12pt/0.05pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; text-indent: -1in; margin-right: 0; margin-left: 1in"><B>Item 1.01 &#9;Entry
into a Material Definitive Agreement</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><I>Securities Purchase Agreement</I></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">On December 28, 2012, Pressure BioSciences, Inc. (the &#8220;<U>Company</U>&#8221;)
entered into a Securities Purchase and Exchange Agreement (the &#8220;<U>Securities Purchase and Exchange Agreement</U>&#8221;)
with Clayton A. Struve, pursuant to which the Company agreed to exchange an aggregate of 10,000 shares of a newly created series
of preferred stock, designated Series H Convertible Preferred Stock, par value $0.01 per share (the &#8220;Series H Convertible
Preferred Stock&#8221;) for 1,000,000 shares of the Company&#8217;s common stock, par value $0.01 per share (&#8220;Common Stock&#8221;)
held by Mr. Struve in a non-cash transaction. [***Discuss:***] Mr. Struve originally purchased the Common Stock from the Company
for $0.8025 per share. The closing price of the Common Stock on the date of the exchange was $0.24.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">The Series H Convertible Preferred Stock is convertible into Common
Stock at a conversion price of $0.8025. The exchange ratio is 100 shares of Common Stock for each share of Series H Convertible
Preferred Stock, or a stated conversion price of $0.8025 per share.. The 10,000 shares of Series H Convertible Preferred Stock
issued to Mr. Struve are therefore convertible into 1,000,000 shares of Common Stock.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">This description of the Securities Purchase and Exchange Agreement
does not purport to be complete and is qualified in its entirety by reference to the Securities Purchase Agreement, a copy of which
is attached to this Current Report on Form 8-K as <FONT STYLE="background-color: yellow">Exhibit 4.1</FONT> and is incorporated
herein by reference.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><I>Series H Convertible Preferred Stock </I></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">The Series H Convertible preferred Stock was created by Amendment
to the Company&#8217;s Restated Articles of Organization, as amended, filed by the Company with the Secretary of the Commonwealth
of Massachusetts on December 28, 2012.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><U>Dividends</U>. The holders of Series H Convertible Preferred
Stock shall be entitled to receive dividends equal (on an as-if-converted into shares of Common Stock basis) to and in the same
form as dividends paid on shares of Common Stock.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><U>Liquidation</U>. Upon liquidation, dissolution or winding up
of the Company, the holders of Series H Convertible Preferred Stock shall be entitled to be paid out of the remaining assets of
the Company available for distribution to the holders of Common Stock (on an as-if-converted into Common Stock basis) on a pari
passu basis with the holders of Common Stock. The Series H Convertible Preferred Stock is junior to the shares of the Company&#8217;s
Series D Preferred Stock and pari passu with the Company&#8217;s Series G Convertible Preferred Stock.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><U>Voluntary Conversion</U>. Each share of Series H Convertible
Preferred Stock is convertible into 100 shares of Common Stock at any time at the option of the holder, subject to adjustment for
stock splits, stock dividends, recapitalizations and similar transactions (the &#8220;<U>Conversion Ratio</U>&#8221;). Unless waived
under certain circumstances by the holder of Series H Convertible Preferred Stock, such holder&#8217;s shares of Series H Convertible
Preferred Stock may not be converted if upon such conversion the holder&#8217;s beneficial ownership would exceed certain thresholds.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><U>Mandatory Conversion</U>. At the election of the Company and
upon written notice, each share of Series H Convertible Preferred Stock will automatically be converted into shares of Common Stock
at the Conversion Ratio then in effect:&nbsp;&nbsp;(i) if the Common Stock trades on the OTC QB Market (or other primary trading
market or exchange on which the Common Stock is then traded) at a price equal to at least $1.50, for 7 out of 10 consecutive trading
days with average daily trading volume of at least 10,000 shares, (ii) on or after the first anniversary of the original issuance
date of the Series H Convertible Preferred Stock or (iii) upon completion of a firm-commitment underwritten registered public offering
by the Company at a per share price equal to at least $1.50, with aggregate gross proceeds to the Company of not less than $2.5
million.&nbsp;&nbsp;Unless waived under certain circumstances by the holder of the Series H Convertible Preferred Stock, such holder&#8217;s
Series H Convertible Preferred Stock may not be converted if upon such conversion the holder&#8217;s beneficial ownership would
exceed certain thresholds.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><U>Voting Rights</U>. The holders of Series H Convertible Preferred
Stock are not entitled to vote on any matters presented to the stockholders of the Company for their action or consideration at
any meeting of stockholders of the Company (or by written consent of stockholders in lieu of meeting), except as required by law.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">This description of the Series H Convertible Preferred Stock does
not purport to be complete and is qualified in its entirety by reference to the Company&#8217;s Articles of Amendment, a copy of
which is attached to this Current Report on Form 8-K as Exhibit 3.1 and is incorporated herein by reference.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><B>Item 5.03&#9;Amendments to Articles of Incorporation or Bylaws;
Change in Fiscal Year</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">See &#8220;Series H Convertible Preferred Stock&#8221; under Item
1.01, above, of this Current Report on Form 8-K. The information set forth therein is incorporated herein by this reference.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 12pt"><B>Item 9.01 &#9;Financial Statements and Exhibits </B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin-right: 0; margin-left: 0">(d)&nbsp;&nbsp;&nbsp;&nbsp;<U> Exhibits</U>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<BR>
<BR>
</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="border-collapse: collapse; width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 10%; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt; font-weight: bold">Exhibit Number&nbsp;</TD>
    <TD STYLE="width: 90%; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt; font-weight: bold">Exhibit Description&nbsp;&nbsp;&nbsp;&nbsp;</TD></TR>
</TABLE>
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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 10%; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">3.1</TD>
    <TD STYLE="width: 90%; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">Articles of Amendment to the Company&#8217;s Restated Articles of Organization, as amended</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">4.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">Securities and Exchange Purchase Agreement</TD></TR>
</TABLE>
<P STYLE="font: 11pt Times New Roman, Times, Serif; margin-right: 0; margin-left: 0">&nbsp;</P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt">&nbsp;</DIV>
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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin-right: 0; margin-left: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B><U>SIGNATURES</U></B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">Pursuant to the requirements of the Securities Exchange Act of 1934,
the Registrant has duly caused this Report to be signed on its behalf by the undersigned, thereunto duly authorized.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 41%; padding-right: 0.8pt; font: 11pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 7%; padding-right: 0.8pt; font: 11pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 52%; padding-right: 0.8pt; font: 11pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 11pt Times New Roman, Times, Serif; padding-right: 0.8pt">Dated: January 3, 2012</TD>
    <TD COLSPAN="2" STYLE="font: bold 11pt Times New Roman, Times, Serif; padding-right: 1.8pt">PRESSURE BIOSCIENCES, INC.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>
        <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P>
        <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P></TD>
    <TD>
        <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P>
        <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P></TD>
    <TD>
        <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;</P>
        <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">&nbsp;/s/ Richard T. Schumacher</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 11pt Times New Roman, Times, Serif; padding-right: 0.8pt">&nbsp;</TD>
    <TD STYLE="font: 11pt Times New Roman, Times, Serif; padding-right: 0.8pt">By:&nbsp;&nbsp;</TD>
    <TD STYLE="font: 11pt Times New Roman, Times, Serif; padding-right: 0.8pt">_____________________________</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font: 11pt Times New Roman, Times, Serif; padding-right: 1.8pt">&nbsp;</TD>
    <TD>
        <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">Richard T. Schumacher</P>
        <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0.8pt 0 0">President</P></TD></TR>
</TABLE>
<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 9pt 0 0">&nbsp;</P>

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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 9pt 0 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center"><B>EXHIBIT INDEX</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 10%; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt; font-weight: bold">Exhibit Number&nbsp;</TD>
    <TD STYLE="width: 90%; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt; font-weight: bold">Exhibit Description&nbsp;&nbsp;&nbsp;&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">3.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">Articles of Amendment to the Company&#8217;s Restated Articles of Organization, as amended</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">4.1</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">Form of Securities Purchase Agreement</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">4.3</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">Registration Rights Agreement (Necesasary?)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; font-size: 11pt">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 9pt 0 0">&nbsp;</P>


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{"company-data": {"conformed-name": "PRESSURE BIOSCIENCES INC", "cik": "0000830656", "assigned-sic": "3826", "irs-number": "042652826", "state-of-incorporation": "MA", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-21615", "film-number": "13508012"}, "business-address": {"street1": "14 NORFOLK AVENUE", "city": "SOUTH EASTON", "state": "MA", "zip": "02375", "phone": "5082301828"}, "mail-address": {"street1": "14 NORFOLK AVENUE", "city": "SOUTH EASTON", "state": "MA", "zip": "02375"}, "former-company": {"former-conformed-name": "BOSTON BIOMEDICA INC", "date-changed": "19960812"}}
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
Current Report Pursuant
to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of Report (Date of earliest event reported)
December 28, 2012
PRESSURE BIOSCIENCES, INC.
(Exact Name of Registrant as Specified
in its Charter)
MASSACHUSETTS
(State or Other Jurisdiction
of Incorporation)
0-21615
04-2652826
(Commission File Number)
(IRS Employer Identification No.)
14 Norfolk Avenue, South Easton, MA
02375
(Address of Principal Executive Offices)
(Zip Code)
(508) 230-1828
(Registrant's Telephone Number,
Including Area Code)
(Former Name or Former Address, if Changed
Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (
see
General Instruction
A.2. below):
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 1.01 	Entry
into a Material Definitive Agreement
Securities Purchase Agreement
On December 28, 2012, Pressure BioSciences, Inc. (the "
Company
")
entered into a Securities Purchase and Exchange Agreement (the "
Securities Purchase and Exchange Agreement
")
with Clayton A. Struve, pursuant to which the Company agreed to exchange an aggregate of 10,000 shares of a newly created series
of preferred stock, designated Series H Convertible Preferred Stock, par value $0.01 per share (the "Series H Convertible
Preferred Stock") for 1,000,000 shares of the Company's common stock, par value $0.01 per share ("Common Stock")
held by Mr. Struve in a non-cash transaction. [***Discuss:***] Mr. Struve originally purchased the Common Stock from the Company
for $0.8025 per share. The closing price of the Common Stock on the date of the exchange was $0.24.
The Series H Convertible Preferred Stock is convertible into Common
Stock at a conversion price of $0.8025. The exchange ratio is 100 shares of Common Stock for each share of Series H Convertible
Preferred Stock, or a stated conversion price of $0.8025 per share.. The 10,000 shares of Series H Convertible Preferred Stock
issued to Mr. Struve are therefore convertible into 1,000,000 shares of Common Stock.
This description of the Securities Purchase and Exchange Agreement
does not purport to be complete and is qualified in its entirety by reference to the Securities Purchase Agreement, a copy of which
is attached to this Current Report on Form 8-K as
Exhibit 4.1
and is incorporated
herein by reference.
Series H Convertible Preferred Stock
The Series H Convertible preferred Stock was created by Amendment
to the Company's Restated Articles of Organization, as amended, filed by the Company with the Secretary of the Commonwealth
of Massachusetts on December 28, 2012.
Dividends
. The holders of Series H Convertible Preferred
Stock shall be entitled to receive dividends equal (on an as-if-converted into shares of Common Stock basis) to and in the same
form as dividends paid on shares of Common Stock.
Liquidation
. Upon liquidation, dissolution or winding up
of the Company, the holders of Series H Convertible Preferred Stock shall be entitled to be paid out of the remaining assets of
the Company available for distribution to the holders of Common Stock (on an as-if-converted into Common Stock basis) on a pari
passu basis with the holders of Common Stock. The Series H Convertible Preferred Stock is junior to the shares of the Company's
Series D Preferred Stock and pari passu with the Company's Series G Convertible Preferred Stock.
Voluntary Conversion
. Each share of Series H Convertible
Preferred Stock is convertible into 100 shares of Common Stock at any time at the option of the holder, subject to adjustment for
stock splits, stock dividends, recapitalizations and similar transactions (the "
Conversion Ratio
"). Unless waived
under certain circumstances by the holder of Series H Convertible Preferred Stock, such holder's shares of Series H Convertible
Preferred Stock may not be converted if upon such conversion the holder's beneficial ownership would exceed certain thresholds.
Mandatory Conversion
. At the election of the Company and
upon written notice, each share of Series H Convertible Preferred Stock will automatically be converted into shares of Common Stock
at the Conversion Ratio then in effect:  (i) if the Common Stock trades on the OTC QB Market (or other primary trading
market or exchange on which the Common Stock is then traded) at a price equal to at least $1.50, for 7 out of 10 consecutive trading
days with average daily trading volume of at least 10,000 shares, (ii) on or after the first anniversary of the original issuance
date of the Series H Convertible Preferred Stock or (iii) upon completion of a firm-commitment underwritten registered public offering
by the Company at a per share price equal to at least $1.50, with aggregate gross proceeds to the Company of not less than $2.5
million.  Unless waived under certain circumstances by the holder of the Series H Convertible Preferred Stock, such holder's
Series H Convertible Preferred Stock may not be converted if upon such conversion the holder's beneficial ownership would
exceed certain thresholds.
Voting Rights
. The holders of Series H Convertible Preferred
Stock are not entitled to vote on any matters presented to the stockholders of the Company for their action or consideration at
any meeting of stockholders of the Company (or by written consent of stockholders in lieu of meeting), except as required by law.
This description of the Series H Convertible Preferred Stock does
not purport to be complete and is qualified in its entirety by reference to the Company's Articles of Amendment, a copy of
which is attached to this Current Report on Form 8-K as Exhibit 3.1 and is incorporated herein by reference.
Item 5.03	Amendments to Articles of Incorporation or Bylaws;
Change in Fiscal Year
See "Series H Convertible Preferred Stock" under Item
1.01, above, of this Current Report on Form 8-K. The information set forth therein is incorporated herein by this reference.
Item 9.01 	Financial Statements and Exhibits
(d)
Exhibits
Exhibit Number
Exhibit Description
3.1
Articles of Amendment to the Company's Restated Articles of Organization, as amended
4.1
Securities and Exchange Purchase Agreement
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934,
the Registrant has duly caused this Report to be signed on its behalf by the undersigned, thereunto duly authorized.
Dated: January 3, 2012
PRESSURE BIOSCIENCES, INC.
/s/ Richard T. Schumacher
By:
_____________________________
Richard T. Schumacher
President
EXHIBIT INDEX
Exhibit Number
Exhibit Description
3.1
Articles of Amendment to the Company's Restated Articles of Organization, as amended
4.1
Form of Securities Purchase Agreement
4.3
Registration Rights Agreement (Necesasary?)