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      Progenics Form 8-K December 1, 2005
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        8-K</strong></font></div>
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        to Section 13 or 15(d) of the Securities Exchange Act of
        1934</strong></font></div>
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        of
        Report (Date of earliest event reported) </font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><u>December
        1, 2005</u></font></div>
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        Pharmaceuticals, Inc.</strong></font></div>
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        name of registrant as specified in its charter)</font></div>
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                  Number)</font></div>
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                  telephone number, including area code </font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><u>(914)
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        the
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        satisfy the filing obligation of the registrant under any of the following
        provisions (</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><em>see
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</font>Written
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</font>Soliciting
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</font>Pre-commencement
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</font>Pre-commencement
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>Item
        7.01. Regulation FD Disclosure</strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><br></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;</font><font id="TAB2" style="COLOR: black; LETTER-SPACING: 27pt">&#160;<font id="TAB2" style="LETTER-SPACING: 9pt">&#160;&#160;&#160;</font>&#160;</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Progenics
        Pharmaceuticals, Inc. announced that it is today initiating a phase 1b clinical
        trial of a new investigational HIV therapy - a humanized monoclonal antibody
        that specifically binds CCR5, a receptor that serves as a portal of entry
        for
        HIV into cells of the immune system. PRO 140 belongs to a new class of drugs,
        viral-entry inhibitors, which are designed to prevent HIV from entering and
        infecting healthy cells. The phase 1b trial is designed to evaluate the
        tolerability, pharmacology and antiviral activity of PRO 140 in patients
        infected with HIV (human immunodeficiency virus), the virus that causes AIDS.
        A
        copy of the press release is attached hereto as Exhibit 99.1 and the information
        contained therein is incorporated by reference into this Item 7.01 of this
        Current Report on Form 8-K.</font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font id="TAB1" style="MARGIN-LEFT: 36pt"></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">The
        information furnished pursuant to Item 7.01 in this Form 8-K shall not be
        deemed
        to be &#8220;filed&#8221; for the purposes of Section 18 of the Securities Exchange Act of
        1934 or otherwise subject to the liabilities of that Section, unless we
        specifically incorporate it by reference in a document filed under the
        Securities Act of 1933 or the Securities Exchange Act of 1934. We undertake
        no
        duty or obligation to publicly update or revise the information furnished
        pursuant to Item 7.01 in this Form 8-K.</font></div>
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        9.01&#160;&#160;&#160;Financial Statements and Exhibits.</strong></font></div>
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        Exhibits </font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong><u>Exhibit
        No.</u></strong></font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;&#160;&#160;&#160;&#160;</font><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong><u>Description</u></strong></font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
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              <td align="right" style="width: 72pt;"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">99.1&#160;&#160;</font></td>
              <td>
                <div style="MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; MARGIN-RIGHT: 0pt" align="justify"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">&#160;&#160;&#160;&#160;
                  Press Release dated December 1, 2005 regarding PRO 140 Phase 1b
                  trial
                  </font></div>
              </td>
            </tr>

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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="center"><a name="p_"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><strong>SIGNATURES</strong></font></a></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Pursuant
        to the requirements of the Securities Exchange Act of 1934, the registrant
        has
        duly caused this report to be signed on its behalf by the undersigned hereunto
        duly authorized.</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 153pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">PROGENICS
        PHARMACEUTICALS, INC.</font></div>
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        ROBERT A.
        MCKINNEY&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</u></font></div>
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        A.
        McKinney</font></div>
      <div style="DISPLAY: block; MARGIN-LEFT: 189pt; TEXT-INDENT: -36pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"><font id="TAB2" style="LETTER-SPACING: 9pt">&#160;&#160;&#160;</font>&#160;Chief
        Financial Officer, Vice President,</font></div>
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        and
        Operations and Treasurer</font></div>
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      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="justify">&#160;</div>
      <div style="DISPLAY: block; MARGIN-LEFT: 0pt; TEXT-INDENT: 0pt; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 0pt" align="left"><font style="DISPLAY: inline; FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman">Date:
        December 1, 2005</font></div>
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Progenics Form 8-K December 1, 2005
SECURITIES
        AND EXCHANGE COMMISSION
Washington,
        D.C. 20549
FORM
        8-K
CURRENT
        REPORT
Pursuant
        to Section 13 or 15(d) of the Securities Exchange Act of
        1934
Date
        of
        Report (Date of earliest event reported)
December
        1, 2005
Progenics
        Pharmaceuticals, Inc.
(Exact
        name of registrant as specified in its charter)
Delaware
000-23143
13-3379479
(State
                  or other jurisdiction
of
                  incorporation)
(Commission
File
                  Number)
(IRS
                  Employer
Identification
                  No.)
777
                  Old Saw Mill River Road, Tarrytown, New York
10591
(Address
                  of principal executive offices)
(Zip
                  Code)
Registrant's
                  telephone number, including area code
(914)
                  789-2800
Check
        the
        appropriate box below if the Form 8-K filing is intended to simultaneously
        satisfy the filing obligation of the registrant under any of the following
        provisions (
see
General
        Instruction A.2. below):
o
Written
        communications
        pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting
        material
        pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement
        communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR
        240.14d-2(b))
o
Pre-commencement
        communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR
        240.13e-4(c))
Item
        7.01. Regulation FD Disclosure
Progenics
        Pharmaceuticals, Inc. announced that it is today initiating a phase 1b clinical
        trial of a new investigational HIV therapy - a humanized monoclonal antibody
        that specifically binds CCR5, a receptor that serves as a portal of entry
        for
        HIV into cells of the immune system. PRO 140 belongs to a new class of drugs,
        viral-entry inhibitors, which are designed to prevent HIV from entering and
        infecting healthy cells. The phase 1b trial is designed to evaluate the
        tolerability, pharmacology and antiviral activity of PRO 140 in patients
        infected with HIV (human immunodeficiency virus), the virus that causes AIDS.
        A
        copy of the press release is attached hereto as Exhibit 99.1 and the information
        contained therein is incorporated by reference into this Item 7.01 of this
        Current Report on Form 8-K.
The
        information furnished pursuant to Item 7.01 in this Form 8-K shall not be
        deemed
        to be "filed" for the purposes of Section 18 of the Securities Exchange Act of
        1934 or otherwise subject to the liabilities of that Section, unless we
        specifically incorporate it by reference in a document filed under the
        Securities Act of 1933 or the Securities Exchange Act of 1934. We undertake
        no
        duty or obligation to publicly update or revise the information furnished
        pursuant to Item 7.01 in this Form 8-K.
Item
        9.01   Financial Statements and Exhibits.
(c)
        Exhibits
Exhibit
        No.
Description
99.1
Press Release dated December 1, 2005 regarding PRO 140 Phase 1b
                  trial
SIGNATURES
Pursuant
        to the requirements of the Securities Exchange Act of 1934, the registrant
        has
        duly caused this report to be signed on its behalf by the undersigned hereunto
        duly authorized.
PROGENICS
        PHARMACEUTICALS, INC.
By:
/s/
        ROBERT A.
        MCKINNEY
Robert
        A.
        McKinney
Chief
        Financial Officer, Vice President,
Finance
        and
        Operations and Treasurer
Date:
        December 1, 2005