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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">UNITED STATES SECURITIES AND EXCHANGE COMMISSION</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Washington, D.C. 20549</font></b></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">FORM&nbsp;8-K</font></b></p>
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<p align="center" style="font-size:12.0pt;margin:0in 0in .0001pt;text-align:center;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">CURRENT REPORT</font></b><b><font style="font-weight:bold;"><br>  </font>Pursuant to Section&nbsp;13 or 15(d)&nbsp;of the Securities Exchange Act of 1934</b></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Date of </font><font size="2" style="font-size:10.0pt;">Report (Date of earliest event reported):<b> &nbsp;September&nbsp;</b></font><b><font size="2" style="font-size:10.0pt;font-weight:bold;">11</font></b><b><font size="2" style="font-size:10.0pt;font-weight:bold;">, 2013</font></b></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">Trius Therapeutics,&nbsp;Inc.</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Exact name of registrant as specified in its charter)</font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Delaware</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">001-34828</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">20-1320630</font></b></p>    </td>   </tr>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(State or other jurisdiction of<br>   incorporation)</font></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(I.R.S. Employer Identification<br>   Number)</font></p>    </td>   </tr>  </table>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">c/o Cubist Pharmaceuticals,&nbsp;Inc.<br> 65 Hayden Avenue</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Lexington, MA 02421<br> (781) 860-8660</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Address of principal executive offices including zip code and registrant&#146;s telephone number, including area code)</font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Check the appropriate box below if the Form&nbsp;8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):</font></p>
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<p style="margin:0in 0in .0001pt .25in;text-indent:-.25in;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">Written communications pursuant to Rule&nbsp;425 under the Securities Act (17 CFR 230.425)</font></p>
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<p style="margin:0in 0in .0001pt .25in;text-indent:-.25in;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">Soliciting material pursuant to Rule&nbsp;14a-12 under the Exchange Act (17 CFR 240.14a-12)</font></p>
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<p style="margin:0in 0in .0001pt .25in;text-indent:-.25in;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">Pre-commencement communications pursuant to Rule&nbsp;14d-2(b)&nbsp;under the Exchange Act (17 CFR 240.14d-2(b))</font></p>
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<p style="margin:0in 0in .0001pt .25in;text-indent:-.25in;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">Pre-commencement communications pursuant to Rule&nbsp;13e-4(c)&nbsp;under the Exchange Act (17 CFR 240.13e-4(c))</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item&nbsp;2.01 Completion of Acquisition or Disposition of Assets.</font></b></p>
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<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">On July&nbsp;30, 2013, Trius Therapeutics,&nbsp;Inc., a Delaware corporation (&#147;Trius&#148;), entered into an Agreement and Plan of Merger (the &#147;Merger Agreement&#148;) with Cubist Pharmaceuticals,&nbsp;Inc. (&#147;Parent&#148;), a Delaware corporation, and BRGO Corporation, a Delaware corporation and a wholly-owned subsidiary of Parent (&#147;Purchaser&#148;). Pursuant to the Merger Agreement, upon the terms and subject to the conditions thereof, Purchaser commenced a tender offer (the &#147;Offer&#148;) on August&nbsp;13, 2013 to acquire all of the outstanding shares of common stock of Trius at a purchase price of $13.50 per share in cash (the &#147;Closing Amount&#148;) plus one non-transferrable contingent value right (&#147;CVR&#148;) per share, which represents the right to receive up to $2.00 if specified sales milestones are achieved within an agreed upon time period (collectively, the Closing Amount and one CVR, the &#147;Consideration&#148;), upon the terms and subject to the conditions set forth in the Offer to Purchase, dated August&nbsp;13, 2013, and the related Letter of Transmittal, each as amended or supplemented from time to time.</font></p>
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<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">On September&nbsp;11, 2013, Parent announced the completion of the Offer. The initial offering period of the Offer expired at 9:00&nbsp;a.m. Eastern time on September&nbsp;11, 2013. According to Computershare Trust Company, N.A., the depositary for the Offer (the &#147;Depositary&#148;), as of 9:00&nbsp;a.m. Eastern time on September&nbsp;11, 2013, a total of </font><font size="2" style="font-size:10.0pt;">31,716,214</font><font size="2" style="font-size:10.0pt;"> shares of Trius common stock was validly tendered and not withdrawn in the Offer, which represented approximately </font><font size="2" style="font-size:10.0pt;">65</font><font size="2" style="font-size:10.0pt;">% of all issued and outstanding shares of Trius common stock.&#160; Purchaser has accepted for payment all shares of Trius common stock that were validly tendered and not withdrawn.</font></p>
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<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">On September&nbsp;</font><font size="2" style="font-size:10.0pt;">11</font><font size="2" style="font-size:10.0pt;">, 2013, pursuant to the terms of the Merger Agreement, Purchaser exercised its top-up option, provided for in Section&nbsp;1.5 of the Merger Agreement, to purchase directly from Trius an additional number of shares of Trius common stock sufficient to give Purchaser ownership of at least 90% of the then outstanding shares of each class of capital stock of Trius entitled to vote on the transaction, when combined with the shares Purchaser purchased in the Offer. Pursuant to the exercise of this top-up option, Purchaser purchased directly from Trius a total of </font><font size="2" style="font-size:10.0pt;">121,334,448</font><font size="2" style="font-size:10.0pt;"> newly issued shares of Trius common stock (the &#147;Top-Up Shares&#148;) at a price of $</font><font size="2" style="font-size:10.0pt;">13.68</font><font size="2" style="font-size:10.0pt;"> per share in consideration for a combination of cash and a promissory note issued to Trius in the aggregate amount of $</font><font size="2" style="font-size:10.0pt;">1,659,855,249</font><font size="2" style="font-size:10.0pt;">. Following the purchase of the Top-Up Shares, on September&nbsp;</font><font size="2" style="font-size:10.0pt;">11</font><font size="2" style="font-size:10.0pt;">, 2013, Purchaser effected a short-form merger (the &#147;Merger&#148;) of Purchaser with and into Trius under Delaware law, without the need for a meeting of Trius&#146;s stockholders, with Trius surviving as a wholly-owned subsidiary of Parent. At the effective time of the Merger (the &#147;Effective Time&#148;), each issued and outstanding share of Trius common stock that was not tendered pursuant to the Offer was cancelled and converted into the right to receive the Consideration (other than shares of Trius common stock that are held by Parent or Purchaser, by Trius as treasury stock, or by stockholders, if any, who properly exercise appraisal rights under Delaware law).</font></p>
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<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Parent provided sufficient funds to Purchaser to acquire all of the outstanding shares of Trius common stock. The aggregate consideration, in the Offer and the Merger (as defined below), for all of the outstanding shares of common stock of Trius is approximately $</font><font size="2" style="font-size:10.0pt;">658 million</font><font size="2" style="font-size:10.0pt;"> in upfront cash payments (such payments to be paid out of current unrestricted funds of Parent) and </font><font size="2" style="font-size:10.0pt;">48,721,843</font><font size="2" style="font-size:10.0pt;"> CVRs, which represent the right to receive up to a maximum aggregate amount of $</font><font size="2" style="font-size:10.0pt;">97,443,686</font><font size="2" style="font-size:10.0pt;"> if specified sales milestones are achieved within an agreed upon time period.</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 3.01.&nbsp; Notice of Delisting or Failure to Satisfy a Continued Listing Rule&nbsp;or Standard; Transfer of Listing.</font></b></p>
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<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The disclosure set forth under Item&nbsp;2.01 above is incorporated herein by reference.</font></p>
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<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">As a result of the Merger, Trius no longer fulfills the numerical listing requirements of The Nasdaq Global Market (&#147;Nasdaq&#148;). Accordingly, on September&nbsp;</font><font size="2" style="font-size:10.0pt;">11</font><font size="2" style="font-size:10.0pt;">, 2013, at Trius&#146; request, Nasdaq filed with the U.S. Securities and Exchange Commission a Notification of Removal from Listing and/or Registration under Section&nbsp;12(b)&nbsp;of the</font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2<a name="PB_2_045201_7056"></a></font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Securities Exchange Act of 1934, as amended, on Form&nbsp;25 thereby effecting the delisting of the Shares from Nasdaq.</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item&nbsp;3.02. Unregistered Sales of Equity Securities.</font></b></p>
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<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The disclosure set forth under Item&nbsp;2.01 above is incorporated herein by reference.</font></p>
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<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The Top-Up Shares were offered and sold to Purchaser in reliance upon exemptions from registration pursuant to Section&nbsp;4(2)&nbsp;under the Securities Act of 1933, as amended, as a transaction by an issuer not involving a public offering.</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item&nbsp;3.03. Material Modification to Rights of Security Holders.</font></b></p>
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<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">At the Effective Time, each issued and outstanding share of Trius common stock (other than shares held in the treasury of Trius and shares owned by the Purchaser or Parent) was converted into the right to (i)&nbsp;receive from Trius the Consideration, or (ii)&nbsp;seek appraisal of such shares under Delaware law. At the Effective Time, Trius stockholders immediately prior to the Effective Time ceased to have any rights as stockholders in Trius (other than their right to receive the Consideration) and accordingly no longer have any interest in Trius&#146; future earnings or growth.</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 5.01. Changes in Control of Registrant.</font></b></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The disclosure set forth under Item&nbsp;2.01 above is incorporated herein by reference.</font></p>
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<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">As a result of the Merger, a change of control of Trius occurred and Trius has become a wholly-owned subsidiary of Parent.</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item&nbsp;5.02. Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers; Compensatory Agreements of Certain Officers.</font></b></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to the terms of the Merger Agreement, immediately prior to the Effective Time on September&nbsp;</font><font size="2" style="font-size:10.0pt;">11</font><font size="2" style="font-size:10.0pt;">, 2013, each of Jeffrey Stein, Ph.D., David S. Kabakoff, Brian G. Atwood, Karin Eastham, Seth H. Z. Fischer, Nina Kjellson, Brendan O&#146;Leary, Theodore R. Schroeder and Paul Truex resigned from the Board of Directors, and any committee thereof, of Trius. Upon consummation of the Merger and pursuant to the Merger Agreement, Michael W. Bonney, Thomas DesRosier and Michael Tomsicek, each of whom is an officer of Purchaser, became the directors of Trius.</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to the terms of the Merger Agreement, the executive officers of Purchaser immediately prior to the Effective Time became the executive officers of Trius following the Merger.&#160; The new executive officers of Trius are Michael W. Bonney, Thomas DesRosier and Michael Tomsicek.</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 5.03. Amendments to Articles of Incorporation or Bylaws; Change of Fiscal Year.</font></b></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">At the Effective Time, Trius&#146;s certificate of incorporation and by-laws were amended and restated in their entirety to be identical to the certificate of incorporation and by-laws of Purchaser as in effect immediately prior to the consummation of the Merger, except that the name of the surviving corporation set forth therein is &#147;Trius Therapeutics,&nbsp;Inc.&#148;&#160; Copies of the restated certificate of incorporation and by-laws of Trius are filed as Exhibits 3.1 and 3.2 to this report and are incorporated by reference in this Item 5.03.</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 9.01&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Financial Statements and Exhibits.</font></b></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(a)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">Financial Statements of Business Acquired.</font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The financial statements required by this Item 9.01(a)&nbsp;will be filed by amendment no later than 71 calendar days after the date on which this Current Report on Form&nbsp;8-K was due for filing.</font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3<a name="PB_3_045307_5335"></a></font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(b)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">Pro Forma Financial Information.</font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The pro forma financial information required by this Item 9.01(b)&nbsp;will be filed by amendment no later than 71 calendar days after the date on which this Current Report on Form&nbsp;8-K was due for filing.</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(d)</font><font size="1" style="font-size:3.0pt;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font><font size="2" style="font-size:10.0pt;">Exhibits</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Exhibit<br>   No.</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Description</font></b></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3.1</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Amended   and Restated Certificate of Incorporation of Trius Therapeutics,&nbsp;Inc.</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3.2</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Amended   and Restated By-Laws of Trius Therapeutics,&nbsp;Inc.</font></p>    </td>   </tr>  </table>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4<a name="PB_4_045337_5796"></a></font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">SIGNATURE</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Date:&nbsp;&nbsp;September&nbsp;</font><font size="2" style="font-size:10.0pt;">11</font><font size="2" style="font-size:10.0pt;">, 2013</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Trius Therapeutics,&nbsp;Inc.</font></b></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.52%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By:</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">/s/&nbsp;THOMAS   DESROSIER</font></i></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.52%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Name:</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Thomas   DesRosier</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Title:</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Secretary</font></p>    </td>   </tr>  </table>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">5<a name="PB_5_045528_2897"></a></font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">EXHIBIT&nbsp;INDEX</font></b></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Description</font></b></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
<td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.92%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
<td width="88%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:88.92%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3.1</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Amended   and Restated Certificate of Incorporation of Trius Therapeutics,&nbsp;Inc.</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
<td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.92%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3.2</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Amended   and Restated By-Laws of Trius Therapeutics,&nbsp;Inc.</font></p>    </td>   </tr>  </table>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">6<a name="PB_6_045637_3020"></a></font></p>
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of
Report (Date of earliest event reported):
September
11
, 2013
Trius Therapeutics, Inc.
(Exact name of registrant as specified in its charter)
Delaware
001-34828
20-1320630
(State or other jurisdiction of
incorporation)
(Commission File Number)
(I.R.S. Employer Identification
Number)
c/o Cubist Pharmaceuticals, Inc.
65 Hayden Avenue
Lexington, MA 02421
(781) 860-8660
(Address of principal executive offices including zip code and registrant's telephone number, including area code)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 2.01 Completion of Acquisition or Disposition of Assets.
On July 30, 2013, Trius Therapeutics, Inc., a Delaware corporation ("Trius"), entered into an Agreement and Plan of Merger (the "Merger Agreement") with Cubist Pharmaceuticals, Inc. ("Parent"), a Delaware corporation, and BRGO Corporation, a Delaware corporation and a wholly-owned subsidiary of Parent ("Purchaser"). Pursuant to the Merger Agreement, upon the terms and subject to the conditions thereof, Purchaser commenced a tender offer (the "Offer") on August 13, 2013 to acquire all of the outstanding shares of common stock of Trius at a purchase price of $13.50 per share in cash (the "Closing Amount") plus one non-transferrable contingent value right ("CVR") per share, which represents the right to receive up to $2.00 if specified sales milestones are achieved within an agreed upon time period (collectively, the Closing Amount and one CVR, the "Consideration"), upon the terms and subject to the conditions set forth in the Offer to Purchase, dated August 13, 2013, and the related Letter of Transmittal, each as amended or supplemented from time to time.
On September 11, 2013, Parent announced the completion of the Offer. The initial offering period of the Offer expired at 9:00 a.m. Eastern time on September 11, 2013. According to Computershare Trust Company, N.A., the depositary for the Offer (the "Depositary"), as of 9:00 a.m. Eastern time on September 11, 2013, a total of
31,716,214
shares of Trius common stock was validly tendered and not withdrawn in the Offer, which represented approximately
65
% of all issued and outstanding shares of Trius common stock.  Purchaser has accepted for payment all shares of Trius common stock that were validly tendered and not withdrawn.
On September
11
, 2013, pursuant to the terms of the Merger Agreement, Purchaser exercised its top-up option, provided for in Section 1.5 of the Merger Agreement, to purchase directly from Trius an additional number of shares of Trius common stock sufficient to give Purchaser ownership of at least 90% of the then outstanding shares of each class of capital stock of Trius entitled to vote on the transaction, when combined with the shares Purchaser purchased in the Offer. Pursuant to the exercise of this top-up option, Purchaser purchased directly from Trius a total of
121,334,448
newly issued shares of Trius common stock (the "Top-Up Shares") at a price of $
13.68
per share in consideration for a combination of cash and a promissory note issued to Trius in the aggregate amount of $
1,659,855,249
. Following the purchase of the Top-Up Shares, on September
11
, 2013, Purchaser effected a short-form merger (the "Merger") of Purchaser with and into Trius under Delaware law, without the need for a meeting of Trius's stockholders, with Trius surviving as a wholly-owned subsidiary of Parent. At the effective time of the Merger (the "Effective Time"), each issued and outstanding share of Trius common stock that was not tendered pursuant to the Offer was cancelled and converted into the right to receive the Consideration (other than shares of Trius common stock that are held by Parent or Purchaser, by Trius as treasury stock, or by stockholders, if any, who properly exercise appraisal rights under Delaware law).
Parent provided sufficient funds to Purchaser to acquire all of the outstanding shares of Trius common stock. The aggregate consideration, in the Offer and the Merger (as defined below), for all of the outstanding shares of common stock of Trius is approximately $
658 million
in upfront cash payments (such payments to be paid out of current unrestricted funds of Parent) and
48,721,843
CVRs, which represent the right to receive up to a maximum aggregate amount of $
97,443,686
if specified sales milestones are achieved within an agreed upon time period.
Item 3.01.  Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing.
The disclosure set forth under Item 2.01 above is incorporated herein by reference.
As a result of the Merger, Trius no longer fulfills the numerical listing requirements of The Nasdaq Global Market ("Nasdaq"). Accordingly, on September
11
, 2013, at Trius' request, Nasdaq filed with the U.S. Securities and Exchange Commission a Notification of Removal from Listing and/or Registration under Section 12(b) of the
2
Securities Exchange Act of 1934, as amended, on Form 25 thereby effecting the delisting of the Shares from Nasdaq.
Item 3.02. Unregistered Sales of Equity Securities.
The disclosure set forth under Item 2.01 above is incorporated herein by reference.
The Top-Up Shares were offered and sold to Purchaser in reliance upon exemptions from registration pursuant to Section 4(2) under the Securities Act of 1933, as amended, as a transaction by an issuer not involving a public offering.
Item 3.03. Material Modification to Rights of Security Holders.
At the Effective Time, each issued and outstanding share of Trius common stock (other than shares held in the treasury of Trius and shares owned by the Purchaser or Parent) was converted into the right to (i) receive from Trius the Consideration, or (ii) seek appraisal of such shares under Delaware law. At the Effective Time, Trius stockholders immediately prior to the Effective Time ceased to have any rights as stockholders in Trius (other than their right to receive the Consideration) and accordingly no longer have any interest in Trius' future earnings or growth.
Item 5.01. Changes in Control of Registrant.
The disclosure set forth under Item 2.01 above is incorporated herein by reference.
As a result of the Merger, a change of control of Trius occurred and Trius has become a wholly-owned subsidiary of Parent.
Item 5.02. Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers; Compensatory Agreements of Certain Officers.
Pursuant to the terms of the Merger Agreement, immediately prior to the Effective Time on September
11
, 2013, each of Jeffrey Stein, Ph.D., David S. Kabakoff, Brian G. Atwood, Karin Eastham, Seth H. Z. Fischer, Nina Kjellson, Brendan O'Leary, Theodore R. Schroeder and Paul Truex resigned from the Board of Directors, and any committee thereof, of Trius. Upon consummation of the Merger and pursuant to the Merger Agreement, Michael W. Bonney, Thomas DesRosier and Michael Tomsicek, each of whom is an officer of Purchaser, became the directors of Trius.
Pursuant to the terms of the Merger Agreement, the executive officers of Purchaser immediately prior to the Effective Time became the executive officers of Trius following the Merger.  The new executive officers of Trius are Michael W. Bonney, Thomas DesRosier and Michael Tomsicek.
Item 5.03. Amendments to Articles of Incorporation or Bylaws; Change of Fiscal Year.
At the Effective Time, Trius's certificate of incorporation and by-laws were amended and restated in their entirety to be identical to the certificate of incorporation and by-laws of Purchaser as in effect immediately prior to the consummation of the Merger, except that the name of the surviving corporation set forth therein is "Trius Therapeutics, Inc."  Copies of the restated certificate of incorporation and by-laws of Trius are filed as Exhibits 3.1 and 3.2 to this report and are incorporated by reference in this Item 5.03.
Item 9.01     Financial Statements and Exhibits.
(a)
Financial Statements of Business Acquired.
The financial statements required by this Item 9.01(a) will be filed by amendment no later than 71 calendar days after the date on which this Current Report on Form 8-K was due for filing.
3
(b)
Pro Forma Financial Information.
The pro forma financial information required by this Item 9.01(b) will be filed by amendment no later than 71 calendar days after the date on which this Current Report on Form 8-K was due for filing.
(d)
Exhibits
Exhibit
No.
Description
3.1
Amended   and Restated Certificate of Incorporation of Trius Therapeutics, Inc.
3.2
Amended   and Restated By-Laws of Trius Therapeutics, Inc.
4
SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Date:  September
11
, 2013
Trius Therapeutics, Inc.
By:
/s/ THOMAS   DESROSIER
Name:
Thomas   DesRosier
Title:
Secretary
5
EXHIBIT INDEX
Exhibit
No.
Description
3.1
Amended   and Restated Certificate of Incorporation of Trius Therapeutics, Inc.
3.2
Amended   and Restated By-Laws of Trius Therapeutics, Inc.
6