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<B><FONT SIZE=4><P ALIGN="CENTER">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B></FONT> </P>
<B><P ALIGN="CENTER">Washington, D.C. 20549</B> </P>
<B><FONT SIZE=5><P ALIGN="CENTER">FORM 8-K</B></FONT> </P>
<P ALIGN="CENTER">CURRENT REPORT </P>
<FONT SIZE=2><P ALIGN="CENTER">Pursuant to Section&nbsp;13 or 15(d) of<BR>
the Securities Exchange Act of 1934 </P>
<P ALIGN="CENTER">Date of Report (Date of earliest event reported): February 3, 2008 </P>
</FONT><B><FONT SIZE=6><P ALIGN="CENTER">COMBINATORX, INCORPORATED</P>
</B></FONT><FONT SIZE=2><P ALIGN="CENTER">(Exact name of Registrant as specified in its charter) </P>
<B><P ALIGN="CENTER">Delaware</B><BR>
(State or other jurisdiction of incorporation) </P></FONT>
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<B><FONT SIZE=2><P ALIGN="CENTER">000-51171</B></FONT></TD>
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<FONT SIZE=2><P>&nbsp;</FONT></TD>
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<B><FONT SIZE=2><P ALIGN="CENTER">04-3514457</B></FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">(Commission File No.)</FONT></TD>
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<FONT SIZE=2><P>&nbsp;</FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">(IRS Employer Identification No.)</FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER"></P>
<B><P ALIGN="CENTER">245 First Street</P>
<P ALIGN="CENTER">Sixteenth Floor<BR>
Cambridge, MA 02142</B></FONT><BR>
<FONT SIZE=2>(Address of principal executive offices and zip code)</P>
<P ALIGN="CENTER">Registrant's telephone number, including area code: <B>(617)&nbsp;301-7000</B> </P></FONT>
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<B><FONT SIZE=2><P ALIGN="CENTER">None</B></FONT></TD>
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<FONT SIZE=2><P ALIGN="CENTER">(Former Name or Former Address, if Changed Since Last Report)</FONT></TD>
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<FONT SIZE=2>
<P>&nbsp;</P>
<P>Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:</P>
<P>&nbsp;</P></FONT>
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<FONT SIZE=1><P>&nbsp;</FONT></TD>
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<FONT SIZE=2><P>Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</FONT></TD>
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<FONT SIZE=2><P>&nbsp;</FONT></TD>
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<FONT SIZE=1><P>&nbsp;</FONT></TD>
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<FONT SIZE=2><P>Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</FONT></TD>
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<FONT FACE="Wingdings" SIZE=2><P>o</FONT></TD>
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<FONT SIZE=1><P>&nbsp;</FONT></TD>
<TD WIDTH="95%" VALIGN="TOP">
<FONT SIZE=2><P>Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</FONT></TD>
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<FONT SIZE=1><P>&nbsp;</FONT></TD>
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<FONT SIZE=2><P>Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</FONT></TD>
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<P><HR ALIGN="RIGHT" SIZE=1></P>
<B><FONT SIZE=2><P>Item 5.02.&#9;Departure of Directors or Certain Officers; Election of Officers; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.</P>
</B><P>&nbsp;</P>
<P>(b)  On February 3, 2008, Dr. Curtis Keith resigned as Senior Vice President, Research of CombinatoRx, Incorporated (the &quot;Company&quot;), effective February 7, 2008.  </P>
<P>(e)  The Company also entered into a consulting agreement pursuant to which Dr. Keith agreed to serve as a member of the Company's Scientific Advisory Board and to provide consulting services to the Company regarding research and development matters.  The consulting agreement is effective as of February 8, 2008, has an initial term through January 31, 2009, and may be terminated by either party upon written notice.  In connection with the consulting agreement, Dr. Keith will be paid $25,000 per year for services to be rendered by him under the consulting agreement.</P>
<P>In connection with Dr. Keith's resignation, the Company agreed to modify the terms of vested stock options held by Dr. Keith on February 7, 2008, exercisable for 272,135 shares of the Company's common stock, to extend the period of time for Dr. Keith to exercise such stock options from May 7, 2008 until 90 days after he no longer serves as a member of our Scientific Advisory Board.</P>
<P>&nbsp;</P>
<P><HR ALIGN="RIGHT" SIZE=1></P>
<B><P>SIGNATURES</P>
</B><P>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. </P>
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<P>COMBINATORX, INCORPORATED</P>
<P>&nbsp;</P>
<P>By:<U>&#9;/s/ Alexis Borisy&#9;&#9;&#9;</P>
</U><P>Name:&#9;Alexis Borisy</P>
<P>Title:&#9;Chief Executive Officer and President</P>
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<P>Dated:  February 7, 2008</FONT> </P></BODY>
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{"company-data": {"conformed-name": "COMBINATORX, INC", "cik": "0001135906", "assigned-sic": "2834", "irs-number": "043514457", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-51171", "film-number": "08585425"}, "business-address": {"street1": "245 FIRST STREET", "street2": "16TH FLOOR", "city": "CAMBRIDGE", "state": "MA", "zip": "02142", "phone": "617-301-7000"}, "mail-address": {"street1": "245 FIRST STREET", "street2": "16TH FLOOR", "city": "CAMBRIDGE", "state": "MA", "zip": "02142"}, "former-company": {"former-conformed-name": "COMBINATORX INC", "date-changed": "20010301"}}
UNITED STATES
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of
the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): February 3, 2008
COMBINATORX, INCORPORATED
(Exact name of Registrant as specified in its charter)
Delaware
(State or other jurisdiction of incorporation)
000-51171
04-3514457
(Commission File No.)
(IRS Employer Identification No.)
245 First Street
Sixteenth Floor
Cambridge, MA 02142
(Address of principal executive offices and zip code)
Registrant's telephone number, including area code:
(617) 301-7000
None
(Former Name or Former Address, if Changed Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 5.02.	Departure of Directors or Certain Officers; Election of Officers; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
(b)  On February 3, 2008, Dr. Curtis Keith resigned as Senior Vice President, Research of CombinatoRx, Incorporated (the "Company"), effective February 7, 2008.
(e)  The Company also entered into a consulting agreement pursuant to which Dr. Keith agreed to serve as a member of the Company's Scientific Advisory Board and to provide consulting services to the Company regarding research and development matters.  The consulting agreement is effective as of February 8, 2008, has an initial term through January 31, 2009, and may be terminated by either party upon written notice.  In connection with the consulting agreement, Dr. Keith will be paid $25,000 per year for services to be rendered by him under the consulting agreement.
In connection with Dr. Keith's resignation, the Company agreed to modify the terms of vested stock options held by Dr. Keith on February 7, 2008, exercisable for 272,135 shares of the Company's common stock, to extend the period of time for Dr. Keith to exercise such stock options from May 7, 2008 until 90 days after he no longer serves as a member of our Scientific Advisory Board.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
COMBINATORX, INCORPORATED
By:
/s/ Alexis Borisy
Name:	Alexis Borisy
Title:	Chief Executive Officer and President
Dated:  February 7, 2008