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<title>Prepared By R.R. Donnelley Financial -- Form 8-K</title>
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<b>UNITED STATES </b></font></div>

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<b>SECURITIES AND EXCHANGE COMMISSION </b></font></div>

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<b>Washington, D.C. 20549 </b></font></div>

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<b>Form 8-K </b></font></div> <div><font Size="1">&nbsp;</font></div>

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<b>Current Report </b></font></div>

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<b>Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 </b></font></div>

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<b>Date of Report (Date of earliest event reported):&nbsp;&nbsp;01/12/2006 </b></font></div>




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<b>VIROPHARMA INCORPORATED </b></font></div>

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<b>(Exact name of registrant as specified in its charter)</b></font></div>

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<b>Commission File Number:&nbsp;&nbsp;0-021699</b></font></div>

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<div Align="center"><font Face="times New Roman" Size="3" Color="#000000"><b>DELAWARE</b></font>
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<div Align="center"><font Face="times New Roman" Size="3" Color="#000000"><b>23-2789550</b></font>
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<b>(State or other jurisdiction of</b></font>
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<div Align="center"><font Face="times New Roman" Size="2" Color="#000000"><b>(IRS Employer</b></font>
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<b>incorporation)</b></font>
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<b>Identification No.)</b></font>
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<b>397 Eagleview Boulevard, Exton, PA 19341</b></font></div>


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<b>(Address of principal executive offices, including zip code)</b></font>
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<b>610-458-7300 </b></font>
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<b>(Registrant&#146;s telephone number, including area code)</b></font>
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<b> </b></font>
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<b>(Former name or former address, if changed since last report) </b></font>
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<b>Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:<BR><BR>
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<b>[&nbsp;&nbsp;]&nbsp;&nbsp;
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<BR><BR>

[&nbsp;&nbsp;]&nbsp;&nbsp;
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<BR><BR>


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Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<BR><BR>


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Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
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Information to be included in the report</b>
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<b>Item 1.01.&nbsp;&nbsp;&nbsp;&nbsp;Entry into a Material Definitive Agreement</b></font>
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Executive Salaries<p>On January 12, 2006, the Compensation Committee of the Board of Directors of ViroPharma Incorporated (the "Company") approved salary increases for the Company's named executive officers. The base salaries of the named executive officers for 2006 are as follows: Michel de Rosen, Chairman and Chief Executive Officer ($375,000); Colin Broom, Vice President and Chief Scientific Officer ($317,000); Vincent Milano, Vice President, Chief Financial Officer and Treasurer ($300,000); Thomas Doyle, Vice President, General Counsel and Secretary ($275,000) and Joshua Tarnoff, Vice President and Chief Commercial Officer ($210,000).  The Company intends to provide additional information regarding the compensation awarded to the named executive officers in respect of and during the year ended December 31, 2005, in the proxy statement for the Company's 2006 annual meeting of stockholders, which is expected to be filed with the Securities and Exchange Commission in March 2006.</font>
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<b>Signature(s) </b></font>
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Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized. </font>
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	VIROPHARMA INCORPORATED</font>
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	Date: January 18, 2006</font>
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	By:</font>
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	/s/&nbsp;&nbsp;&nbsp;&nbsp;Thomas F. Doyle</font>
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	Thomas F. Doyle</font>
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	<div><font Face="times New Roman" Size="2" Color="#000000">Vice President General Counsel</font>
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{"company-data": {"conformed-name": "VIROPHARMA INC", "cik": "0000946840", "assigned-sic": "2834", "irs-number": "232789550", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-21699", "film-number": "06535722"}, "business-address": {"street1": "397 EAGLEVIEW BLVD", "city": "EXTON", "state": "PA", "zip": "19341", "phone": "6104587300"}, "mail-address": {"street1": "397 EAGLEVIEW BOULEVARD", "city": "EXTON", "state": "PA", "zip": "19341"}}
Prepared By R.R. Donnelley Financial -- Form 8-K
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 8-K
Current Report
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported):  01/12/2006
VIROPHARMA INCORPORATED
(Exact name of registrant as specified in its charter)
Commission File Number:  0-021699
DELAWARE
23-2789550
(State or other jurisdiction of
(IRS Employer
incorporation)
Identification No.)
397 Eagleview Boulevard, Exton, PA 19341
(Address of principal executive offices, including zip code)
610-458-7300
(Registrant's telephone number, including area code)
(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
[  ]  
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
[  ]  
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
[  ]  
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
[  ]  
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Information to be included in the report
Item 1.01.    Entry into a Material Definitive Agreement
Executive Salaries
On January 12, 2006, the Compensation Committee of the Board of Directors of ViroPharma Incorporated (the "Company") approved salary increases for the Company's named executive officers. The base salaries of the named executive officers for 2006 are as follows: Michel de Rosen, Chairman and Chief Executive Officer ($375,000); Colin Broom, Vice President and Chief Scientific Officer ($317,000); Vincent Milano, Vice President, Chief Financial Officer and Treasurer ($300,000); Thomas Doyle, Vice President, General Counsel and Secretary ($275,000) and Joshua Tarnoff, Vice President and Chief Commercial Officer ($210,000).  The Company intends to provide additional information regarding the compensation awarded to the named executive officers in respect of and during the year ended December 31, 2005, in the proxy statement for the Company's 2006 annual meeting of stockholders, which is expected to be filed with the Securities and Exchange Commission in March 2006.
Signature(s)
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.
VIROPHARMA INCORPORATED
Date: January 18, 2006
By:
/s/    Thomas F. Doyle
Thomas F. Doyle
Vice President General Counsel