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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">UNITED STATES<br> SECURITIES AND EXCHANGE COMMISSION</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Washington, D.C. 20549</font></b></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">FORM&nbsp;8-K</font></b></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">CURRENT REPORT</font></b></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="3" face="Times New Roman" style="font-size:12.0pt;font-weight:bold;">Pursuant to Section&nbsp;13 or 15(d)&nbsp;of the Securities Exchange Act of 1934</font></b></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Date of Report (Date of earliest event reported) <b>September&nbsp;27, 2013</b></font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="5" face="Times New Roman" style="font-size:18.0pt;font-weight:bold;">GTx,&nbsp;Inc.</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Exact name of registrant as specified in its charter)</font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Delaware</font></b><font size="2" style="font-size:10.0pt;"><br>   (State or other jurisdiction of <br>   incorporation or organization)</font></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">000-50549</font></b><font size="2" style="font-size:10.0pt;"><br>   (Commission</font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">File Number)</font></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">62-1715807</font></b><font size="2" style="font-size:10.0pt;"><br>   (I.R.S. Employer<br>   Identification No.)</font></p>    </td>   </tr>  </table>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">175 Toyota Plaza<br>   7th Floor<br>   Memphis, Tennessee </font></b><font size="2" style="font-size:10.0pt;"><br>   (Address of principal executive offices)</font></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">38103<br>    </font></b><font size="2" style="font-size:10.0pt;">(Zip Code)</font></p>    </td>   </tr>  </table>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Registrant&#146;s telephone number, including area code: <b>(901) 523-9700</b></font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">(Former name or former address, if changed since last report)</font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Check the appropriate box below if the Form&nbsp;8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (<i>see</i> General Instruction A.2. below):</font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font><font size="2" style="font-size:10.0pt;"> Written communications pursuant to Rule&nbsp;425 under the Securities Act (17 CFR 230.425)</font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font><font size="2" style="font-size:10.0pt;"> Soliciting material pursuant to Rule&nbsp;14a-12 under the Exchange Act (17 CFR 240.14a-12)</font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font><font size="2" style="font-size:10.0pt;"> Pre-commencement communications pursuant to Rule&nbsp;14d-2(b)&nbsp;under the Exchange Act (17 CFR 240.14d-2(b))</font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Wingdings" style="font-size:10.0pt;">o</font><font size="2" style="font-size:10.0pt;"> Pre-commencement communications pursuant to Rule&nbsp;13e-4(c)&nbsp;under the Exchange Act (17 CFR 240.13e-4(c))</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 2.05&#160;&#160;&#160;&#160;&#160; Costs Associated with Exit or Disposal Activities.</font></b></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">On September&nbsp;27, 2013, the Compensation Committee of the Board of Directors (the &#147;Compensation Committee&#148;) of GTx,&nbsp;Inc. (&#147;GTx&#148; or the &#147;Company&#148;) committed to implementing a workforce reduction of 53 non-executive employees, constituting approximately 60% of the Company&#146;s workforce. The Company notified employees affected by the workforce reduction on October&nbsp;1, 2013. All affected employees will be eligible to receive, among other things, </font><font size="2" style="font-size:10.0pt;">specified severance payments based on the applicable employee&#146;s level and years of service with the Company and the </font><font size="2" style="font-size:10.0pt;">continuation of group </font><font size="2" style="font-size:10.0pt;">health</font><font size="2" style="font-size:10.0pt;"> insurance coverage through October&nbsp;31, 2013. In addition, the affected employees will also be eligible for the partial acceleration of vesting of their outstanding unvested stock options and an extension of the post-termination exercise period for their outstanding vested stock options.</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">On August&nbsp;19, 2013, the Company announced that its two pivotal Phase 3 clinical trials evaluating enobosarm 3 mg for the prevention and treatment of muscle wasting in patients with advanced non-small cell lung cancer failed to meet the overall criteria for the co-primary responder endpoints of lean body mass and physical function as agreed upon with the United States Food and Drug Administration. The Company is undertaking the workforce reduction to reduce its expenses </font><font size="2" style="font-size:10.0pt;">and preserve capital</font><font size="2" style="font-size:10.0pt;"> while determining the appropriate path forward for enobosarm 3 mg and completing the Company&#146;s current Phase 2 clinical trials of enobosarm 9 mg to treat breast cancer and GTx-758 (Capesaris</font><font size="1" style="font-size:6.5pt;position:relative;top:-3.0pt;">&#174;</font><font size="2" style="font-size:10.0pt;">) to treat advanced prostate cancer. The Company expects to complete the workforce reduction by the end of October&nbsp;2013.</font></p>
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<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">As a result of the workforce reduction, the Company estimates that it will record in the fourth quarter of 2013, a one-time severance-related charge totaling approximately $1.3 million. The Company does not expect to record a non-cash charge related to the modification of outstanding stock options in connection with the workforce reduction. The severance-related charge, which is expected to represent cash expenditures that the Company expects to incur in connection with the workforce reduction, is subject to a number of assumptions, and actual results may differ materially. The Company may also incur other charges or cash expenditures not currently contemplated due to events that may occur as a result of, or associated with, the workforce reduction.</font></p>
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<p style="margin:0in 0in .0001pt .75in;text-indent:-.75in;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Item 5.02</font></b><b><font size="1" style="font-size:3.0pt;font-weight:bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </font></b><b><font size="2" style="font-size:10.0pt;font-weight:bold;">Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.</font></b></p>
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<p style="margin:0in 0in .0001pt;"><b><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;font-weight:bold;">Officer Resignation</font></i></b></p>
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<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">On September&nbsp;27, 2013, Mark E. Mosteller, the Company&#146;s Vice President, Chief Financial Officer and Treasurer, notified GTx of his intent to resign from the Company, effective December&nbsp;31, 2013, to pursue other interests. Mr.&nbsp;Mosteller is resigning his position in good standing with GTx, having served as a senior officer of the Company for in excess of twelve years.</font></p>
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<p style="margin:0in 0in .0001pt;"><b><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;font-weight:bold;">Executive Compensation Arrangements</font></i></b></p>
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<p style="margin:0in 0in .0001pt;"><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">Executive Base Salary Reductions</font></i></p>
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<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">In connection with the workforce reduction reported under Item 2.05 above and as part of the Company&#146;s efforts to reduce its expenses </font><font size="2" style="font-size:10.0pt;">and preserve capital, the Compensation Committee approved the following salary reductions for the below-identified executive officers, in each case effective October&nbsp;1, 2013:</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Executive&nbsp;Officer</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Pre-Reduction</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;"><br>    </font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">Annual&nbsp;Base<br>   Salary</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;"><br>    </font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">($)</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Annual&nbsp;Base<br>   Salary&nbsp;Effective<br>   October&nbsp;1,&nbsp;2013</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;"><br>    </font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">($)</font></b></p>    </td>
<td width="1%" valign="bottom" style="padding:0in 0in 0in 0in;width:1.0%;">
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt 10.0pt;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Mitchell S. Steiner </font></p>    </td>
<td width="2%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt 10.0pt;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Chief Executive Officer and Vice-Chairman of the Board</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
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<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">565,110</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
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<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">452,088</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt 10.0pt;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Marc S. Hanover </font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">President and Chief   Operating Officer</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="15%" valign="bottom" style="padding:0in 0in 0in 0in;width:15.0%;">
<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">491,646</font></p>    </td>
<td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="15%" valign="bottom" style="padding:0in 0in 0in 0in;width:15.0%;">
<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">393,317</font></p>    </td>
<td width="1%" valign="bottom" style="padding:0in 0in 0in 0in;width:1.0%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>   </tr>
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<td width="18%" valign="top" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:18.5%;">
<p style="margin:0in 0in .0001pt 10.0pt;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">James T. Dalton </font></p>    </td>
<td width="2%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="43%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:43.0%;">
<p style="margin:0in 0in .0001pt 10.0pt;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Vice President, Chief Scientific Officer</font></p>    </td>
<td width="2%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="15%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:15.0%;">
<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">430,560</font></p>    </td>
<td width="2%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="15%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:15.0%;">
<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">375,000</font></p>    </td>
<td width="1%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:1.0%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>   </tr>  </table>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">2<a name="PB_2_074744_5796"></a></font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">Retention Compensation Arrangements</font></i></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">As part of the Company&#146;s efforts to retain the essential employees continuing with GTx following the workforce reduction reported under Item 2.05 above, the Company implemented the following retention benefits and arrangements applicable to its continuing executive officers (except that, as noted below, neither Dr.&nbsp;Steiner nor Mr.&nbsp;Hanover are eligible to receive any retention cash bonuses and they were not granted the retention equity awards that were granted to the Company&#146;s other continuing executive officers):</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">Retention Bonus Program</font></i></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><i><u><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">Cash Bonuses</font></u></i><font size="2" style="font-size:10.0pt;">. Pursuant to a Retention Bonus Program approved by the Compensation Committee on September&nbsp;27, 2013, James T. Dalton, the Company&#146;s Vice President, Chief Scientific Officer, and Henry P. Doggrell, the Company&#146;s Vice President, Chief Legal Officer and Secretary, will be entitled to a cash retention bonus equal to 50% of the </font><font size="2" style="font-size:10.0pt;">then current base salary of the applicable executive officer if the executive officer remains an employee of GTx through the earlier to occur of (i)&nbsp;the end of business on May&nbsp;31, 2014, (ii)&nbsp;</font><font size="2" style="font-size:10.0pt;">an involuntary termination of employment by the Company (excluding a termination for cause (as defined in the applicable form of retention benefits agreement) or a voluntary resignation)</font><font size="2" style="font-size:10.0pt;">, and (iii)&nbsp;a change of control of GTx (as defined in </font><font size="2" style="font-size:10.0pt;">the applicable form of retention benefits agreement</font><font size="2" style="font-size:10.0pt;">). In addition, in connection with the adoption of the Retention Bonus </font><font size="2" style="font-size:10.0pt;">Program</font><font size="2" style="font-size:10.0pt;">, the Compensation Committee suspended cash bonus award eligibility under the GTx,&nbsp;Inc. Executive Bonus Compensation Plan until such time as the Compensation Committee determines to re-instate such eligibility. Accordingly, all executive officers of GTx cease to be eligible for a performance bonus award under the GTx,&nbsp;Inc. Executive Bonus Compensation Plan for 2013.</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><i><u><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">Option Modifications</font></u></i><i><font size="2" style="font-size:10.0pt;font-style:italic;">. </font></i><font size="2" style="font-size:10.0pt;">On </font><font size="2" style="font-size:10.0pt;">September&nbsp;27, 2013, the Compensation Committee also approved the modification of all then outstanding stock options held by the Company&#146;s continuing employees (including all of the Company&#146;s executive officers continuing with the Company) as part of the Retention Bonus Program. As approved by the Compensation Committee, each such outstanding stock option will be modified to provide that if the applicable executive officer&#146;s service continues through the earlier to occur of (i)&nbsp;the end of business on May&nbsp;31, 2014, and (ii)&nbsp;an involuntary termination of employment by the Company (excluding a termination for cause (as defined in the applicable form of retention benefits agreement) or a voluntary resignation) (the &#147;Determination Date&#148;), then, as of the Determination Date: (i)&nbsp;an additional number of shares subject to such option will immediately vest as if the applicable executive&#146;s service had continued through January&nbsp;1, 2015 and (ii)&nbsp;the period during which the vested portion of such options will generally expire will be extended from 90 days to six months after the executive officer&#146;s termination of service (subject to further extension under certain circumstances per the original terms of the stock option awards), subject in each case to the earlier expiration of the original term of the applicable stock option award.</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><i><u><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">Extended Post-Termination Health Coverage Benefit</font></u></i><i><font size="2" style="font-size:10.0pt;font-style:italic;">.&#160; </font></i><font size="2" style="font-size:10.0pt;">On </font><font size="2" style="font-size:10.0pt;">September&nbsp;27, 2013, the Compensation Committee approved the provision of extended health insurance coverage benefits to all continuing employees of the Company (including all of the Company&#146;s executive officers continuing with the Company) as part of the Retention Bonus Program. As approved by the Compensation Committee, if an executive officer&#146;s service continues through the end of business on May&nbsp;31, 2014 and thereafter such service is terminated for any reason (other than for cause, as defined in the applicable form of retention benefits agreement), including a voluntary termination, then such executive officer will be entitled to </font><font size="2" style="font-size:10.0pt;">monthly premium payments from GTx to continue such executive officer&#146;s health insurance coverage through December&nbsp;31, 2014 (or, if earlier, the date on which the executive officer becomes eligible for coverage under the group health insurance of a subsequent employer or is otherwise no longer eligible for such continued coverage).&#160; In addition, if an executive officer&#146;s service is terminated by the Company prior to June&nbsp;1, 2014 for any reason (other than for cause, as defined in the </font><font size="2" style="font-size:10.0pt;">applicable form of retention </font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">3<a name="PB_3_074753_2897"></a></font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">benefits agreement</font><font size="2" style="font-size:10.0pt;">), then such executive officer will be entitled to the monthly premium payments described in the preceding sentence. No such benefits will be provided to any employee or executive officer who voluntarily resigns prior to June&nbsp;1, 2014.</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The foregoing is only a brief description of the material terms of the Retention Bonus Program, does not purport to be complete, and is qualified in its entirety by reference to the applicable forms of retention benefits agreement that will be filed as exhibits to the Company&#146;s quarterly report on Form&nbsp;10-Q for the quarterly period ended September&nbsp;30, 2013.</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><i><font size="2" face="Times New Roman" style="font-size:10.0pt;font-style:italic;">Equity Grants</font></i></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">On </font><font size="2" style="font-size:10.0pt;">September&nbsp;27, 2013</font><font size="2" style="font-size:10.0pt;">, the Compensation Committee approved the grant of stock options and restricted stock units (&#147;RSUs&#148;) under the Company&#146;s 2013 Equity Incentive Plan (the &#147;2013 EIP&#148;) to Messrs.&nbsp;Dalton and Doggrell. The number of shares of GTx common stock underlying the grants, which grants were made effective on October&nbsp;1, 2013 (the &#147;Grant Date&#148;), is set forth in the table below:</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
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<p style="margin:0in 0in .0001pt;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Executive&nbsp;Officer</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Title</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Shares&nbsp;of&nbsp;GTx<br>   common&nbsp;stock<br>   underlying</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;"><br>    </font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">Stock&nbsp;Options</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;"><br>    </font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">(#)</font></b></p>    </td>
<td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>
<td width="12%" valign="bottom" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:12.0%;">
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:8.0pt;font-weight:bold;">Shares&nbsp;of&nbsp;GTx<br>   common&nbsp;stock<br>   underlying</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;"><br>    </font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">RSUs</font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;"><br>    </font></b><b><font size="1" style="font-size:8.0pt;font-weight:bold;">(#)</font></b></p>    </td>
<td width="1%" valign="bottom" style="padding:0in 0in 0in 0in;width:1.0%;">
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="1" face="Times New Roman" style="font-size:1.0pt;font-weight:bold;">&nbsp;</font></b></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt 10.0pt;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">James T. Dalton </font></p>    </td>
<td width="2%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="40%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;border:none;padding:0in 0in 0in 0in;width:40.0%;">
<p style="margin:0in 0in .0001pt 10.0pt;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Vice President, Chief Scientific Officer</font></p>    </td>
<td width="2%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="20%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;border:none;padding:0in 0in 0in 0in;width:20.0%;">
<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">100,000</font></p>    </td>
<td width="2%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="12%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;border:none;padding:0in 0in 0in 0in;width:12.0%;">
<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">100,000</font></p>    </td>
<td width="1%" valign="bottom" bgcolor="#CCEEFF" style="background:#CCEEFF;padding:0in 0in 0in 0in;width:1.0%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>   </tr>
<tr>
<td width="19%" valign="top" style="padding:0in 0in 0in 0in;width:19.5%;">
<p style="margin:0in 0in .0001pt 10.0pt;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Henry P. Doggrell </font></p>    </td>
<td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="40%" valign="bottom" style="padding:0in 0in 0in 0in;width:40.0%;">
<p style="margin:0in 0in .0001pt 10.0pt;text-indent:-10.0pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Vice President, Chief Legal Officer and Secretary</font></p>    </td>
<td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="20%" valign="bottom" style="padding:0in 0in 0in 0in;width:20.0%;">
<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">100,000</font></p>    </td>
<td width="2%" valign="bottom" style="padding:0in 0in 0in 0in;width:2.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="12%" valign="bottom" style="padding:0in 0in 0in 0in;width:12.0%;">
<p align="right" style="margin:0in 0in .0001pt;text-align:right;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">100,000</font></p>    </td>
<td width="1%" valign="bottom" style="padding:0in 0in 0in 0in;width:1.0%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>   </tr>  </table>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">The stock options issued on the Grant Date have an exercise price equal to the fair market value of GTx common stock on the Grant Date, as determined in accordance with the terms of the 2013 EIP, and have a term of 10 years. Each of the stock options and the RSUs will vest in full on </font><font size="2" style="font-size:10.0pt;">the earlier to occur of (i)&nbsp;June&nbsp;1, 2014, (ii)&nbsp;an involuntary termination of the award holder&#146;s continuous service by the Company other than for cause (as defined in the applicable form of award agreement)</font><font size="2" style="font-size:10.0pt;"> and (iii)&nbsp;a change of control of GTx (as defined in </font><font size="2" style="font-size:10.0pt;">the applicable form of award agreement</font><font size="2" style="font-size:10.0pt;">), except that vesting will not occur in the event of a voluntary resignation or </font><font size="2" style="font-size:10.0pt;">involuntary termination</font><font size="2" style="font-size:10.0pt;"> for cause occurring prior to any of these events. As a general matter, the vested portion of the stock options will expire six months after the applicable executive officer&#146;s last day of service. The foregoing is only a brief description of the material terms of the stock options and RSUs granted to the above-named executive officers, does not purport to be complete, and is qualified in its entirety by reference to (i)&nbsp;the 2013 EIP, previously filed as Exhibit&nbsp;99.1 to the Company&#146;s registration statement on Form&nbsp;S-8 (File No.&nbsp;333-188377) filed on May&nbsp;6, 2013, (ii)&nbsp;the related form of stock option grant notice and form of stock option agreement for the retention stock option awards that will be filed as an exhibit to the Company&#146;s quarterly report on Form&nbsp;10-Q for the quarterly period ended September&nbsp;30, 2013, and (iii)&nbsp;the related form of restricted stock unit grant notice and form of restricted stock unit award agreement that will be filed as an exhibit to the Company&#146;s quarterly report on Form&nbsp;10-Q for the quarterly period ended September&nbsp;30, 2013.</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">As a result of Mr.&nbsp;Mosteller&#146;s pending resignation, he is not a participant in the compensation arrangements discussed above under &#147;<i>Executive Compensation Arrangements&#151;Retention Compensation Arrangements</i>.&#148;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.25in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">Forward-Looking Information is Subject to Risk and Uncertainty</font></b></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">This current report on Form&nbsp;8-K contains forward-looking statements based upon GTx&#146;s current expectations. Forward-looking statements involve risks and uncertainties, and include, but are not limited to, statements related to the expected </font><font size="2" style="font-size:10.0pt;">charges and related cash expenditures that the Company expects to incur and not to incur in connection with the workforce reduction</font><font size="2" style="font-size:10.0pt;">, the timing for completion of the </font><font size="2" style="font-size:10.0pt;">workforce reduction</font><font size="2" style="font-size:10.0pt;">, and the Company&#146;s plans to </font><font size="2" style="font-size:10.0pt;">focus on determining the appropriate path forward for enobosarm 3 mg and completing the Company&#146;s current Phase 2 clinical trials of enobosarm 9 mg and GTx-758 (Capesaris</font><font size="1" style="font-size:6.5pt;position:relative;top:-3.0pt;">&#174;</font><font size="2" style="font-size:10.0pt;">). </font><font size="2" style="font-size:10.0pt;">GTx&#146;s actual results and the timing of </font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">4<a name="PB_4_074758_3020"></a></font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, the risks (i)&nbsp;that the workforce reduction charges, costs and expenditures may be greater than currently anticipated; (ii)&nbsp;related to the impact of the workforce reduction on the Company&#146;s business and unanticipated charges not currently contemplated that may occur as a result of the workforce reduction; (iii)&nbsp;that clinical trials being conducted by GTx may not be completed on schedule, or at all, or may otherwise be suspended or terminated; or (iv)&nbsp;that GTx could utilize its available cash resources sooner than it currently expects and may be unable to raise capital when needed, which would force GTx to delay, reduce or eliminate its product candidate development programs. You should not place undue reliance on these forward-looking statements, which apply only as of the date of this current report on Form&nbsp;8-K. GTx&#146;s quarterly report on Form&nbsp;10-Q filed with the Securities and Exchange Commission on July&nbsp;22, 2013 contains under the heading, &#147;Risk Factors&#148;, a more comprehensive description of these and other risks to which GTx is subject. GTx expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in its expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based.</font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">5<a name="PB_5_074802_7748"></a></font></p>
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<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><b><font size="2" face="Times New Roman" style="font-size:10.0pt;font-weight:bold;">SIGNATURES</font></b></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p style="margin:0in 0in .0001pt;text-indent:.5in;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</font></p>
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">GTx,&nbsp;Inc.</font></p>    </td>   </tr>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
<td width="43%" valign="top" style="padding:0in 0in 0in 0in;width:43.6%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
<td width="5%" valign="top" style="padding:0in 0in 0in 0in;width:5.84%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>   </tr>
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<td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.4%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
<td width="43%" valign="top" style="padding:0in 0in 0in 0in;width:43.6%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
<td width="5%" valign="top" style="padding:0in 0in 0in 0in;width:5.84%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>
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<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>    </td>   </tr>
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<td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.4%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Date:</font></p>    </td>
<td width="43%" valign="top" style="padding:0in 0in 0in 0in;width:43.6%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">October&nbsp;1,   2013</font></p>    </td>
<td width="5%" valign="top" style="padding:0in 0in 0in 0in;width:5.84%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">By:</font></p>    </td>
<td width="44%" colspan="2" valign="top" style="border:none;border-bottom:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:44.16%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">/s/   Henry P. Doggrell</font></p>    </td>   </tr>
<tr>
<td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.4%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="43%" valign="top" style="padding:0in 0in 0in 0in;width:43.6%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="5%" valign="top" style="padding:0in 0in 0in 0in;width:5.84%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="6%" valign="top" style="border:none;padding:0in 0in 0in 0in;width:6.66%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Name:</font></p>    </td>
<td width="37%" valign="top" style="border:none;border-top:solid windowtext 1.0pt;padding:0in 0in 0in 0in;width:37.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Henry   P. Doggrell</font></p>    </td>   </tr>
<tr>
<td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.4%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="43%" valign="top" style="padding:0in 0in 0in 0in;width:43.6%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="5%" valign="top" style="padding:0in 0in 0in 0in;width:5.84%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:1.0pt;">&nbsp;</font></p>    </td>
<td width="6%" valign="top" style="padding:0in 0in 0in 0in;width:6.66%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Title:</font></p>    </td>
<td width="37%" valign="top" style="padding:0in 0in 0in 0in;width:37.5%;">
<p style="margin:0in 0in .0001pt;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">Vice   President, Chief Legal Officer and Secretary</font></p>    </td>   </tr>  </table>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">&nbsp;</font></p>
<p align="center" style="margin:0in 0in .0001pt;text-align:center;"><font size="2" face="Times New Roman" style="font-size:10.0pt;">6<a name="PB_6_074806_141"></a></font></p>
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{"company-data": {"conformed-name": "GTX INC /DE/", "cik": "0001260990", "assigned-sic": "2834", "irs-number": "621715807", "state-of-incorporation": "DE", "fiscal-year-end": "1231"}, "filing-values": {"form-type": "8-K", "act": "34", "file-number": "000-50549", "film-number": "131127307"}, "business-address": {"street1": "175 TOYOTA PLAZA", "street2": "7TH FLOOR", "city": "MEMPHIS", "state": "TN", "zip": "38103", "phone": "901-523-9700"}, "mail-address": {"street1": "175 TOYOTA PLAZA", "street2": "7TH FLOOR", "city": "MEMPHIS", "state": "TN", "zip": "38103"}}
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported)
September 27, 2013
GTx, Inc.
(Exact name of registrant as specified in its charter)
Delaware
(State or other jurisdiction of
incorporation or organization)
000-50549
(Commission
File Number)
62-1715807
(I.R.S. Employer
Identification No.)
175 Toyota Plaza
7th Floor
Memphis, Tennessee
(Address of principal executive offices)
38103
(Zip Code)
Registrant's telephone number, including area code:
(901) 523-9700
(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (
see
General Instruction A.2. below):
o
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Item 2.05      Costs Associated with Exit or Disposal Activities.
On September 27, 2013, the Compensation Committee of the Board of Directors (the "Compensation Committee") of GTx, Inc. ("GTx" or the "Company") committed to implementing a workforce reduction of 53 non-executive employees, constituting approximately 60% of the Company's workforce. The Company notified employees affected by the workforce reduction on October 1, 2013. All affected employees will be eligible to receive, among other things,
specified severance payments based on the applicable employee's level and years of service with the Company and the
continuation of group
health
insurance coverage through October 31, 2013. In addition, the affected employees will also be eligible for the partial acceleration of vesting of their outstanding unvested stock options and an extension of the post-termination exercise period for their outstanding vested stock options.
On August 19, 2013, the Company announced that its two pivotal Phase 3 clinical trials evaluating enobosarm 3 mg for the prevention and treatment of muscle wasting in patients with advanced non-small cell lung cancer failed to meet the overall criteria for the co-primary responder endpoints of lean body mass and physical function as agreed upon with the United States Food and Drug Administration. The Company is undertaking the workforce reduction to reduce its expenses
and preserve capital
while determining the appropriate path forward for enobosarm 3 mg and completing the Company's current Phase 2 clinical trials of enobosarm 9 mg to treat breast cancer and GTx-758 (Capesaris
®
) to treat advanced prostate cancer. The Company expects to complete the workforce reduction by the end of October 2013.
As a result of the workforce reduction, the Company estimates that it will record in the fourth quarter of 2013, a one-time severance-related charge totaling approximately $1.3 million. The Company does not expect to record a non-cash charge related to the modification of outstanding stock options in connection with the workforce reduction. The severance-related charge, which is expected to represent cash expenditures that the Company expects to incur in connection with the workforce reduction, is subject to a number of assumptions, and actual results may differ materially. The Company may also incur other charges or cash expenditures not currently contemplated due to events that may occur as a result of, or associated with, the workforce reduction.
Item 5.02
Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
Officer Resignation
On September 27, 2013, Mark E. Mosteller, the Company's Vice President, Chief Financial Officer and Treasurer, notified GTx of his intent to resign from the Company, effective December 31, 2013, to pursue other interests. Mr. Mosteller is resigning his position in good standing with GTx, having served as a senior officer of the Company for in excess of twelve years.
Executive Compensation Arrangements
Executive Base Salary Reductions
In connection with the workforce reduction reported under Item 2.05 above and as part of the Company's efforts to reduce its expenses
and preserve capital, the Compensation Committee approved the following salary reductions for the below-identified executive officers, in each case effective October 1, 2013:
Executive Officer
Title
Pre-Reduction
Annual Base
Salary
($)
Annual Base
Salary Effective
October 1, 2013
($)
Mitchell S. Steiner
Chief Executive Officer and Vice-Chairman of the Board
565,110
452,088
Marc S. Hanover
President and Chief   Operating Officer
491,646
393,317
James T. Dalton
Vice President, Chief Scientific Officer
430,560
375,000
2
Retention Compensation Arrangements
As part of the Company's efforts to retain the essential employees continuing with GTx following the workforce reduction reported under Item 2.05 above, the Company implemented the following retention benefits and arrangements applicable to its continuing executive officers (except that, as noted below, neither Dr. Steiner nor Mr. Hanover are eligible to receive any retention cash bonuses and they were not granted the retention equity awards that were granted to the Company's other continuing executive officers):
Retention Bonus Program
Cash Bonuses
. Pursuant to a Retention Bonus Program approved by the Compensation Committee on September 27, 2013, James T. Dalton, the Company's Vice President, Chief Scientific Officer, and Henry P. Doggrell, the Company's Vice President, Chief Legal Officer and Secretary, will be entitled to a cash retention bonus equal to 50% of the
then current base salary of the applicable executive officer if the executive officer remains an employee of GTx through the earlier to occur of (i) the end of business on May 31, 2014, (ii)
an involuntary termination of employment by the Company (excluding a termination for cause (as defined in the applicable form of retention benefits agreement) or a voluntary resignation)
, and (iii) a change of control of GTx (as defined in
the applicable form of retention benefits agreement
). In addition, in connection with the adoption of the Retention Bonus
Program
, the Compensation Committee suspended cash bonus award eligibility under the GTx, Inc. Executive Bonus Compensation Plan until such time as the Compensation Committee determines to re-instate such eligibility. Accordingly, all executive officers of GTx cease to be eligible for a performance bonus award under the GTx, Inc. Executive Bonus Compensation Plan for 2013.
Option Modifications
.
On
September 27, 2013, the Compensation Committee also approved the modification of all then outstanding stock options held by the Company's continuing employees (including all of the Company's executive officers continuing with the Company) as part of the Retention Bonus Program. As approved by the Compensation Committee, each such outstanding stock option will be modified to provide that if the applicable executive officer's service continues through the earlier to occur of (i) the end of business on May 31, 2014, and (ii) an involuntary termination of employment by the Company (excluding a termination for cause (as defined in the applicable form of retention benefits agreement) or a voluntary resignation) (the "Determination Date"), then, as of the Determination Date: (i) an additional number of shares subject to such option will immediately vest as if the applicable executive's service had continued through January 1, 2015 and (ii) the period during which the vested portion of such options will generally expire will be extended from 90 days to six months after the executive officer's termination of service (subject to further extension under certain circumstances per the original terms of the stock option awards), subject in each case to the earlier expiration of the original term of the applicable stock option award.
Extended Post-Termination Health Coverage Benefit
.
On
September 27, 2013, the Compensation Committee approved the provision of extended health insurance coverage benefits to all continuing employees of the Company (including all of the Company's executive officers continuing with the Company) as part of the Retention Bonus Program. As approved by the Compensation Committee, if an executive officer's service continues through the end of business on May 31, 2014 and thereafter such service is terminated for any reason (other than for cause, as defined in the applicable form of retention benefits agreement), including a voluntary termination, then such executive officer will be entitled to
monthly premium payments from GTx to continue such executive officer's health insurance coverage through December 31, 2014 (or, if earlier, the date on which the executive officer becomes eligible for coverage under the group health insurance of a subsequent employer or is otherwise no longer eligible for such continued coverage).  In addition, if an executive officer's service is terminated by the Company prior to June 1, 2014 for any reason (other than for cause, as defined in the
applicable form of retention
3
benefits agreement
), then such executive officer will be entitled to the monthly premium payments described in the preceding sentence. No such benefits will be provided to any employee or executive officer who voluntarily resigns prior to June 1, 2014.
The foregoing is only a brief description of the material terms of the Retention Bonus Program, does not purport to be complete, and is qualified in its entirety by reference to the applicable forms of retention benefits agreement that will be filed as exhibits to the Company's quarterly report on Form 10-Q for the quarterly period ended September 30, 2013.
Equity Grants
On
September 27, 2013
, the Compensation Committee approved the grant of stock options and restricted stock units ("RSUs") under the Company's 2013 Equity Incentive Plan (the "2013 EIP") to Messrs. Dalton and Doggrell. The number of shares of GTx common stock underlying the grants, which grants were made effective on October 1, 2013 (the "Grant Date"), is set forth in the table below:
Executive Officer
Title
Shares of GTx
common stock
underlying
Stock Options
(#)
Shares of GTx
common stock
underlying
RSUs
(#)
James T. Dalton
Vice President, Chief Scientific Officer
100,000
100,000
Henry P. Doggrell
Vice President, Chief Legal Officer and Secretary
100,000
100,000
The stock options issued on the Grant Date have an exercise price equal to the fair market value of GTx common stock on the Grant Date, as determined in accordance with the terms of the 2013 EIP, and have a term of 10 years. Each of the stock options and the RSUs will vest in full on
the earlier to occur of (i) June 1, 2014, (ii) an involuntary termination of the award holder's continuous service by the Company other than for cause (as defined in the applicable form of award agreement)
and (iii) a change of control of GTx (as defined in
the applicable form of award agreement
), except that vesting will not occur in the event of a voluntary resignation or
involuntary termination
for cause occurring prior to any of these events. As a general matter, the vested portion of the stock options will expire six months after the applicable executive officer's last day of service. The foregoing is only a brief description of the material terms of the stock options and RSUs granted to the above-named executive officers, does not purport to be complete, and is qualified in its entirety by reference to (i) the 2013 EIP, previously filed as Exhibit 99.1 to the Company's registration statement on Form S-8 (File No. 333-188377) filed on May 6, 2013, (ii) the related form of stock option grant notice and form of stock option agreement for the retention stock option awards that will be filed as an exhibit to the Company's quarterly report on Form 10-Q for the quarterly period ended September 30, 2013, and (iii) the related form of restricted stock unit grant notice and form of restricted stock unit award agreement that will be filed as an exhibit to the Company's quarterly report on Form 10-Q for the quarterly period ended September 30, 2013.
As a result of Mr. Mosteller's pending resignation, he is not a participant in the compensation arrangements discussed above under "
Executive Compensation Arrangements—Retention Compensation Arrangements
."
Forward-Looking Information is Subject to Risk and Uncertainty
This current report on Form 8-K contains forward-looking statements based upon GTx's current expectations. Forward-looking statements involve risks and uncertainties, and include, but are not limited to, statements related to the expected
charges and related cash expenditures that the Company expects to incur and not to incur in connection with the workforce reduction
, the timing for completion of the
workforce reduction
, and the Company's plans to
focus on determining the appropriate path forward for enobosarm 3 mg and completing the Company's current Phase 2 clinical trials of enobosarm 9 mg and GTx-758 (Capesaris
®
).
GTx's actual results and the timing of
4
events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, the risks (i) that the workforce reduction charges, costs and expenditures may be greater than currently anticipated; (ii) related to the impact of the workforce reduction on the Company's business and unanticipated charges not currently contemplated that may occur as a result of the workforce reduction; (iii) that clinical trials being conducted by GTx may not be completed on schedule, or at all, or may otherwise be suspended or terminated; or (iv) that GTx could utilize its available cash resources sooner than it currently expects and may be unable to raise capital when needed, which would force GTx to delay, reduce or eliminate its product candidate development programs. You should not place undue reliance on these forward-looking statements, which apply only as of the date of this current report on Form 8-K. GTx's quarterly report on Form 10-Q filed with the Securities and Exchange Commission on July 22, 2013 contains under the heading, "Risk Factors", a more comprehensive description of these and other risks to which GTx is subject. GTx expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in its expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based.
5
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
GTx, Inc.
Date:
October 1,   2013
By:
/s/   Henry P. Doggrell
Name:
Henry   P. Doggrell
Title:
Vice   President, Chief Legal Officer and Secretary
6